@article{ca0f099bbf2a435cee8f97bef5e8cbaa_whitejohna_2025, title = {2025 European guideline on the management of Chlamydia trachomatis infections}, author = {White, John A. and Dukers-Muijrers, Nicole Htm and Hoebe, Christian Jpa and Kenyon, Chris R. and Dc Ross, Jonathan and Unemo, Magnus}, year = {2025}, journal = {International Journal of STD and AIDS (London)}, volume = {36}, number = {6}, pages = {434--449}, doi = {10.1177/09564624251323678}, url = {1942604}, language = {eng}, publisher = {Royal Society of Medicine Press}, keywords = {chlamydia trachomatis; europe; antibiotic; diagnosis; treatment}, abstract = {Sexually transmitted Chlamydia trachomatis infections remain common globally and most frequently are asymptomatic. The 2025 European C. trachomatis guideline provides up-to-date guidance regarding indications for testing and treatment of C. trachomatis infections. It includes advice on urogenital and extragenital C. trachomatis testing including the use of self-collected specimens; recommendation to use only validated NAATs for diagnosis; and recommendation to treat all C. trachomatis infections with doxycycline as first line in preference to single-dose azithromycin regimens. The absence of evidence and limited value of broad screening in asymptomatic populations for C. trachomatis infections is also discussed.}, issn = {0956-4624} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_henrymichaelw_2025, title = {2025 ICM : Use of Antibiotics for Individualized Agents}, author = {Henry, Michael W. and Rezaie, Arash Aali and Shahi, Alisina and Vaznaisiene, Danguole and Abedi, Armita Armina and Aboltins, Craig and Baek, Seung-Hoon and Clark, Benjamin and Comeche, Belén and Reyes Copello, Jose F. and Fujie, Atsuhiro and Gibon, Emmanuel and Hammad, Abdullah and Han, Hyuk-Soo and Hughes, Harriet and Kassam, Al-Amin and Mathis, Kenneth and Mitton, Barend C. and Moshirabadi, Ataollah and Nelson, Renjy and Restrepo, Nicolas J. and Ronde-Oustau, Cécile and Tevell, Staffan and Warren, Simon and Woc-Colburn, Laila and Wouthuyzen-Bakker, Marjan}, year = {2025}, journal = {The Journal of Arthroplasty}, volume = {41}, number = {1, Sup.1}, pages = {S170--S176}, doi = {10.1016/j.arth.2025.10.100}, url = {2010955}, language = {eng}, publisher = {Elsevier}, issn = {0883-5403} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sadekfouadz_2025, title = {2025 ICM : Use of Newer Antibiotics and Fluoroquinolone-Resistance}, author = {Sadek, Fouad Z. and Tevell, Staffan and Lora-Tamayo, Jaime and Tikhilov, Rashid M. and Aboltins, Craig and Belden, Katherine A. and Bue, Mats and Clark, Ben and Doub, James B. and Dzhavadov, Alisagib A. and Goh, Graham S. and Gómez-Junyent, Joan and Hewlett, Angela and Kocaoğlu, Hakan and Kramer, Tobias Siegfried and Küehl, Richard and Martinez, Leibnitz J. and Morata, Laura and Pardo, Dolors Rodriguez and Saeed, Mohammad and Schwarz, Edward and Sharma, Sunil and Urish, Kenneth L. and Young, Bernadette}, year = {2025}, journal = {The Journal of Arthroplasty}, volume = {41}, number = {1, Sup. 1}, pages = {S196--S205}, doi = {10.1016/j.arth.2025.10.094}, url = {2010907}, language = {eng}, publisher = {Elsevier}, issn = {0883-5403} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alijagicandi_2025, title = {3D printing : Balancing innovation for sustainability with emerging environmental and health risks}, author = {Alijagic, Andi and Suljevic, Damir and Engwall, Magnus and Särndahl, Eva}, year = {2025}, journal = {iScience}, volume = {28}, number = {8}, doi = {10.1016/j.isci.2025.113185}, url = {1991252}, language = {eng}, publisher = {Cell Press}, abstract = {The rapid rise of 3D printing, both in industrial and home settings, presents emerging health and environmental risks. While 3D printing enhances sustainability by reducing waste and optimizing resource use, its impact on human health remains poorly understood. The use of metals and polymers linked to health risks, coupled with the release of inhalable particles and volatile organic compounds, raises concerns about respiratory and systemic effects. The absence of clear guidelines creates high public demand for information and limits safe implementation, particularly in schools and homes where millions of 3D printers are expected by 2030. Additionally, improper disposal of 3D printing polymer materials may exacerbate plastic pollution. This article proposes the perspective of a structured risk assessment framework set on particle emissions from industrial 3D printing. It will offer a practical tool to bridge current knowledge gaps and to inform safe practice and policy development, because immediate action is necessary to balance innovation with safety.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_deutschmannmats_2025, title = {A Bird’s-Eye View of the Sociolinguistic Landscape of Seychelles}, author = {Deutschmann, Mats}, year = {2025}, journal = {Seychelles Research Journal (SRJ)}, volume = {7}, number = {2}, pages = {18--33}, doi = {10.5281/zenodo.16730813}, url = {1997997}, language = {eng}, publisher = {University of Seychelles}, keywords = {seychelles; language policy; sociolinguistics; seselwa; trilingual policy}, abstract = {The article gives an overview of Seychelles’ language ecology in various domains  including politics, the judiciary, education, media, religion as well as the language practices ‘in the street’ and of everyday informal communication. In Seychelles, Kreol Seselwa serves as the primary language for informal oral communication, while English dominates in formal oral contexts. This dynamic shifts depending on the domain. For instance, in the judiciary, English is exclusively used for official oral proceedings, whereas all debates in the National Assembly are conducted in Kreol Seselwa. In the education system, Kreol Seselwa is the medium of instruction during the first two years, after which English becomes the primary language. In written communication, English overwhelmingly prevails, except for the verbatim records of political debates in the National Assembly, which are transcribed in Kreol Seselwa. French, meanwhile, plays only a minor role, mainly in religious and cultural contexts, such as traditional songs. Seychellois language ideologies surrounding Kreol Seselwa and English are complex and often contradictory. While many Seychellois take pride in their mother tongue, viewing it as a core part of their national identity and recognizing its importance in national language policy, negative perceptions persist, particularly regarding its formal use in education and professional settings. These conflicting attitudes likely stem from the country’s colonial history and evolving societal structures. The article closes with identifying gaps in current sociolinguistic research where language use and code mixing in social media is identified as a particularly interesting area of investigation.}, file = {https://oru.diva-portal.org/smash/get/diva2:1997997/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vallalisbeth_2025, title = {A cluster randomised controlled trial investigating the effectiveness of the 'Support group' intervention in primary schools in Norway : A study protocol}, author = {Valla, Lisbeth and Sparboe-Nilsen, Bente and Kvarme, Lisbeth G. and Bjerketveit, Therese Haugerud and Hagen, Milada and Winje, Brita Askeland}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {5}, doi = {10.1371/journal.pone.0323794}, url = {1959571}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {Bullying is a pervasive public health issue that significantly affects the mental and physical well-being of children, often leading to long-term consequences that persist into adulthood, such as mental health disorders, social isolation, and economic challenges. Despite numerous interventions implemented in schools, bullying remains a persistent problem. The Support Group intervention, based on a solution-focused approach (SFA), aims to address bullying by enhancing peer support and empowering children within the school environment. This study seeks to evaluate the effectiveness of this intervention in reducing bullying and improving class environment, mental health, quality of life, and self-efficacy among 5th-7th grade Norwegian schoolchildren compared to usual care. This cluster randomized controlled trial (RCT) will be conducted in 26 primary schools across three municipalities in central-eastern Norway. Schools will be randomized to either the intervention group, which will implement the Support Group intervention, or the control group, which will continue with usual care based on national guidelines. Data will be collected at baseline, post-intervention, and at 6- and 9-month thereafter. A parallel process evaluation will be conducted to assess the fidelity and quality of the intervention's implementation and to identify factors associated with its success. The intervention will be compared with usual care using generalised mixed models for repeated measures. This study will provide crucial insights into the effectiveness of the Support Group intervention in reducing bullying and promoting mental health among schoolchildren. The findings are expected to inform best practices in bullying prevention and contribute to the development of more effective, evidence-based interventions in school settings. The trial outcomes will be pivotal in shaping future strategies for creating safer and more supportive school environments in Norway. The study is registered in Clinical trial registration: Trial registration (NCT) 06578260.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_nogaaljosa_2025, title = {A Commentary on the Ironies of the Western Approach to Self-Determination and Secession in International Law, with the Quebec and Scotland Rulings}, author = {Noga, Aljosa and Danckwardt, Petter}, year = {2025}, pages = {55--94}, url = {2008523}, language = {eng}, publisher = {Iustus förlag} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_chaudhrivinayk_2025, title = {A community-driven vision for a new knowledge resource for AI}, author = {Chaudhri, Vinay K. and Baru, Chaitan and Bennett, Brandon and Bhatt, Mehul and Cassel, Darion and Cohn, Anthony G. and Dechter, Rina and Erdem, Esra and Ferrucci, Dave and Forbus, Ken and Gelfond, Gregory and Genesereth, Michael and Gordon, Andrew S. and Grosof, Benjamin and Gupta, Gopal and Hendler, Jim and Israni, Sharat and Josephson, Tyler R. and Kyllonen, Patrick and Lierler, Yuliya and Lifschitz, Vladimir and Mcfate, Clifton and Mcginty, Hande Kucuk and Morgenstern, Leora and Oltramari, Alessandro and Paritosh, Praveen and Roth, Dan and Shepard, Blake and Shimizu, Cogan and Vrandecic, Denny and Whiting, Mark and Witbrock, Michael}, year = {2025}, journal = {The AI Magazine}, volume = {46}, number = {4}, doi = {10.1002/aaai.70035}, url = {2011578}, language = {eng}, publisher = {John Wiley & Sons}, abstract = {The long-standing goal of creating a comprehensive, multi-purpose knowledge resource, reminiscent of the 1984 Cyc project, still persists in AI. Despite the success of knowledge resources like WordNet, ConceptNet, Wolfram|Alpha and other commercial knowledge graphs, verifiable, general-purpose, widely available sources of knowledge remain a critical deficiency in AI infrastructure. Large language models struggle due to knowledge gaps; robotic planning lacks necessary world knowledge; and the detection of factually false information relies heavily on human expertise. What kind of knowledge resource is most needed in AI today? How can modern technology shape its development and evaluation? A recent AAAI workshop gathered over 50 researchers to explore these questions. This paper synthesizes our findings and outlines a community-driven vision for a new knowledge infrastructure. In addition to leveraging contemporary advances in knowledge representation and reasoning, one promising idea is to build an open engineering framework to exploit knowledge modules effectively within the context of practical applications. Such a framework should include sets of conventions and social structures that are adopted by contributors.}, issn = {0738-4602} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_pottershelley_2025, title = {A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials}, author = {Potter, Shelley and Avery, Kerry and Ahmed, Rosina and de Boniface, Jana and Chatterjee, Sanjoy and Dodwell, David and Dubsky, Peter and Federmann, Jingjing and Finestone, Sandra and Gnant, Michael and Hlauschek, Dominik and Iwata, Hiroji and Jiang, Michael Y. and Kaidar-Person, Orit and Lee, Han-Byoel and MacKenzie, Mairead and Meyn, Anne and Poortmans, Philip and Poulakaki, Fiorita and Richardson, Andrea L. and Sepulveda, Karla A. and Spillane, Andrew J. and Thompson, Alastair M. and Werutsky, Gustavo and Wittmann, Philipp and Wright, Jean L. and Zdenkowski, Nicholas and Cowan, Katherine and McIntosh, Stuart A.}, year = {2025}, journal = {npj Breast Cancer}, volume = {11}, number = {1}, doi = {10.1038/s41523-025-00824-w}, url = {2028409}, language = {eng}, publisher = {Springer Nature}, abstract = {Accurate information about locoregional breast cancer treatments following neoadjuvant systemic therapy (NST) is essential for meaningful interpretation of oncological outcomes but reporting is currently poor. We developed a core outcome set (COS) to improve the quality and consistency of locoregional outcome reporting in breast cancer NST trials. The COS was developed in three phases according to COS-STAD guidance, with the generation of a list of relevant outcome domains, prioritisation of outcomes through two rounds of an international online multi-stakeholder Delphi survey and a consensus meeting. 159 unique locoregional outcomes were classified into 101 outcome domains for inclusion in the Delphi survey, which was completed by 470 international professionals. The final 15-item COS, which included the pre-NST surgical plan, details of surgery performed following completion of treatment and details of radiation therapy, was agreed at an in-person consensus meeting. Widespread COS implementation will improve the quality and value of future NST trials.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dijkhorstphillipj_2025, title = {A Core set of patient-reported outcome measures to measure quality of life in obesity treatment research}, author = {Dijkhorst, Phillip J. and de Vries, Claire E. E. and Terwee, Caroline B. and Janssen, Ignace M. C. and Liem, Ronald S. L. and van Wagensveld, Bart A. and Ottosson, Johan and Halpern, Bruno and Flint, Stuart W. and van Rossum, Elisabeth F. C. and Saadi, Alend and West-Smith, Lisa and O'Kane, Mary and Halford, Jason C. G. and Coulman, Karen D. and Al-Sabah, Salman and Dixon, John B. and Brown, Wendy A. and Salas, Ximena Ramos and Hoogbergen, Maarten M. and Abbott, Sally and Budin, Alyssa J. and Holland, Jennifer F. and Poulsen, Lotte and Welbourn, Richard and Ruanova, Bernardo Rea and Morton, John M. and Pattou, Francois and Akpinar, Erman O. and Sogg, Stephanie and Himpens, Jacques M. and Osborne, Vanessa and Wijling, Natasja and Divine, Laura and Isack, Nadya and Birney, Susie and Keenan, J M Bernadette and Nadglowski, Joe and Bowman, Jacqueline and Clare, Ken and Meloni, Riccardo and de Blaeij, Sandra and Kyle, Theodore K. and Bahlke, Melanie and Healing, Andrew and Patton, Ian and Monpellier, Valerie M.}, year = {2025}, journal = {Obesity Reviews}, volume = {26}, number = {2}, doi = {10.1111/obr.13849}, url = {1908121}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {bariatric surgery; obesity treatment; patient‐reported outcome; quality of life}, abstract = {The lack of standardization in patient-reported outcome measures (PROMs) has made measurement and comparison of quality of life (QoL) outcomes in research focused on obesity treatment challenging. This study reports on the results of the second and third global multidisciplinary Standardizing Quality of life measures in Obesity Treatment (S.Q.O.T.) consensus meetings, where a core set of PROMs to measure nine previously selected patient-reported outcomes (PROs) in obesity treatment research was established. The S.Q.O.T. II online and S.Q.O.T. III face-to-face hybrid consensus meetings were held in October 2021 and May 2022. The meetings were led by an independent moderator specializing in PRO measurement. Nominal group techniques, Delphi exercises, and anonymous voting were used to select the most suitable PROMs by consensus. The meetings were attended by 28 and 27 participants, respectively, including a geographically diverse selection of people living with obesity (PLWO) and experts from various disciplines. Out of 24 PROs and 16 PROMs identified in the first S.Q.O.T. consensus meeting, the following nine PROs and three PROMs were selected via consensus: BODY-Q (physical function, physical symptoms, psychological function, social function, eating behavior, and body image), IWQOL-Lite (self-esteem), and QOLOS (excess skin). No PROM was selected to measure stigma as existing PROMs deemed to be inadequate. A core set of PROMs to measure QoL in research focused on obesity treatment has been selected incorporating patients' and experts' opinions. This core set should serve as a minimum to use in obesity research studies and can be combined with clinical parameters.}, issn = {1467-7881} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_ahlgrenanna_2025, title = {A Critical Genealogy of Summative and Formative Assessment in Education}, author = {Ahlgren, Anna and Lundahl, Christian}, year = {2025}, pages = {35--36}, url = {1997741}, language = {eng}, keywords = {examination; assessment; formative; summative; foucault; subjectivity; normalization}, abstract = {This presentation explores educational assessment practices as techniques for governmentality and as crucial tools for the construction of the knowing subject through contemporary schooling. When the history of assessment has been written, the connection between epistemology and subjectivity has rarely been considered, but, as we will show, the epistemology in curricula contributed to the development of certain specific assessmen tpractices, which fosters particular subjectivities, through relations of power and knowledge.We analyze the history of examinations in relation to how different assessment practices shape different abilities, such as memory, judgement, imagination, reflexivity etc, and their connection to truths and reasoning. Our discussion expands on the typical understanding of Foucault's concept of examination (1975) and introduces the organization of students as both objects and subjects of knowledge. Thus, examinations can be delineated into two categories of knowledge-producing practices: one administrative practice focused on organizing individuals, and one teaching practice through which knowledge and learning are constructed – also known as summative and formative assessments.Our presentation builds on a genealogy of assessments in education. A close reading of Swedish curricula from the late 16th century to the early 19th century provides the backdrop for an examination of contemporary notions and practices of assessment in 21st century curricula. With shifting emphasis over time, assessments in education serve a governmental function, validating both the knowledge acquired and its epistemological foundations. This situates the subjects in an epistemological position where they are trained to develop an evaluative judgement, enabling them to distinguish basically between ‘good’ and ‘poor’ work (Boud et al., 2018). However, this subject position - a learner with control over their own learning (Nulty 2010) - becomes normalized through the everyday practice of assessments, which risks obscuring the relations between power, learning and knowledge.We suggest that these relations are partly framed within the practices of assessment, and that the subject is tied to certain forms of knowledge, through the processes of examination, and additionally that knowledge is validated and vindicated through these practices, governing learner subjects as well as teacher subjects.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_dinibojanam_2025, title = {A cross-national perspective of prejudice-based cyberbullying and cybervictimisation}, author = {Dinić, Bojana M. and Bodro, Bojanaža and Jovanovic, Tamará and Hinić, Darko and Puharic, Zrinká and Puharic, Filip and Šperka, Roman and Bauerov, Radká and Koprivov, Veroniká and Voda, Ana Iolanda and Cautisanu, Cristina and Obada, Daniel-Rareş and Iliev, Dean and Pachemska, Tatjana Atanasova and Angeleski, Marjan and Mazzucato, Annaleda and Assche, Jasper Van and DeSmet, Ann and Gao, Shang and Xu, Bibo and Chen, Zhuo and Helmy, Mai and Osma, Esraa and Gad, Israa and Arat, NikolettÓ and Siegler, Anna and Kulcsár, Gabriella and Kohli, Neena and Chawla, Sarabjeet Kaur and Kumar, Vipul and Najamussaqib, Arooj and Amin, Rizwana and Kowal, Marta and Piskorz, Joanna and Szczygiel, Monika and Kornienko, Dmitriy and Veraksa, Alexander and Košir, Katja and Pivec, Tina and Peras, Igor and Chavanovanich, Jennifer and Suvanbenjakule, Piraorn and Ermagan-Caglar, Eda and Kurtça, Tugba Türk and Hamzaoglu, Nurcan and Pyzalski, Jacek}, year = {2025}, pages = {148--165}, doi = {10.4324/9781003439202-9}, url = {1921641}, language = {eng}, publisher = {Routledge}, abstract = {Although much literature has focused on prejudice-based traditional bullying, there are not a lot of studies about prejudice-based cyberbullying. This kind of cyberbullying reflects any form of cyberbullying based on a group affiliation or identity characteristics of the victim, often including historically marginalised and other "protected characteristics" (race, religion, disability, etc.). In this chapter, we focus on seven characteristics that were highlighted in previous research - family origin, skin colour, religion/belief, nationality/ethnicity, disability, poverty, and sexual orientation. We begin by reviewing research into prejudice-based cyberbullying and emphasise the main gaps in the existing knowledge. We then present our empirical findings based on an online study that contributes to filling these gaps: (a) the prevalence of prejudice-based cyberbullying and cybervictimisation at the cross-national level, across 17 countries and including culturally diverse samples (N = 5,215 high school students); and (b) the relationships of belonging to some of the marginalised groups (based on sex, nationality/ethnicity, religion, asylum status, and disability) with both prejudice-based cyberbullying and cybervictimisation. Finally, we refer to some suggestions for future research and conclude with the implications for prevention programmes based on the obtained results.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kimansung_2025, title = {A field experiment on expert- versus social-based cues on dish selection in a restaurant}, author = {Kim, Ansung and Baptista, Iuri and Zorell, Carolin and Neuman, Nicklas and Niimi, Jun and Öström, Åsa}, year = {2025}, journal = {Journal of Environmental Psychology}, volume = {108}, doi = {10.1016/j.jenvp.2025.102806}, url = {2010106}, language = {eng}, publisher = {Academic Press}, keywords = {field experiment; food choice; influence; plant-based}, abstract = {This field experiment explored whether and to what extent claims about expert recommendations (i.e., those of the chef) and recommendations from other restaurant guests influenced customers' food choices in a restaurant. The menu in the study consisted entirely of vegetarian dishes, two of which were selected to be emphasised either as “Chef's choice” or as “Guests' choice” on the menu, thereby providing expert-based and social-based cues suggesting one of the dishes at different study time points. The selected dishes were a vegetarian version of a conventional Swedish meat dish (a plant-based patty) and a nonconventional dish (lentils with “zero-waste” pesto). Over four weeks, the restaurant's sales data were collected, and customers were invited to participate in a voluntary survey. This survey gathered information regarding sociodemographic characteristics and more details about the dish selection, including subjective ratings of dish liking and overall meal satisfaction. A total of 1540 dishes were sold, and 524 customers participated in the survey. The plant-based patty was the most popular choice across all weeks, and the “Chef's choice” had no additive effect, suggesting its high stability in popularity. Labelling a less popular dish (lentils with “zero-waste” pesto) with “Chef's choice” had a positive impact on its selection, while labelling it with “Guests' choice” made no difference. These results suggest that in the absence of meat options, some customers appear to transfer the concept of a meat-centric dish to a similar vegetarian dish (in this case, a plant-based patty), whereas a less popular dish with no resemblance to a conventional meat dish can become more popular when recommended by a presumable expert on the matter. However, further research is necessary to ascertain the efficacy of this effect in diverse restaurant contexts, based on designs with better possibilities to establish causality.}, issn = {0272-4944} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dobrosavljevicmaja_2025, title = {A five-year risk prediction model of cardiovascular disease in individuals with bipolar disorder : a nationwide register study from Sweden}, author = {Dobrosavljevic, Maja and Landén, Mikael and Brikell, Isabell and Chang, Zheng and Kuja-Halkola, Ralf and Lichtenstein, Paul and Andell, Pontus and Andreassen, Ole A. and Bauer, Michael and Corcoy, Rosa and de Girolamo, Giovanni and Reif, Andreas and Larsson, Henrik and Garcia-Argibay, Miguel}, year = {2025}, journal = {Molecular Psychiatry}, doi = {10.1038/s41380-025-03381-7}, url = {2023715}, language = {eng}, publisher = {Springer Nature}, abstract = {Cardiovascular disease (CVD) risk prediction models for the general population may not provide accurate predictions in individuals with bipolar disorder (BD) who have elevated risks of cardiometabolic conditions and premature mortality. Therefore, we aimed to: 1) develop a five-year CVD risk prediction model in this population by using nationwide register data from Sweden, 2) investigate whether the performance improved when we considered additional risk factors, including psychiatric comorbidity, psychotropic medication, and socio-demographic variables, compared to using established CVD risk factors only, and 3) whether machine learning approach provided improvements compared to standard logistic regression models. We followed 33,933 persons with BD aged 30-82 years old, without previous CVD, from the date of BD diagnosis registered between 2007-2014, for up to five years. The logistic regression model containing only established risk factors yielded an area under the receiver operating characteristic curve (AUC) of 0.76 (95% confidence interval 0.74-0.78) in the test dataset, while the logistic regression model and the best performing machine learning model including additional predictors yielded similar results (AUC was 0.77 (0.75, 0.79) in both models). The performance of logistic regression models slightly improved with additional predictors when continuous risk scores were used. In conclusion, standard logistic regression and established CVD risk factors may be sufficient to predict CVD in individuals with BD when using population register-based data from Sweden. External validation across diverse healthcare settings and rigorous assessment of clinical impact will be crucial next steps before implementing these models in clinical practice.}, issn = {1359-4184} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_stergrendaniel_2025, title = {A gastronomic approach to popular education – a research idea}, author = {Östergren, Daniel}, year = {2025}, url = {1962013}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_arribascristina_2025, title = {A global cross-sectional survey on neonatal analgosedation: unveiling global trends and challenges through latent class analysis}, author = {Arribas, Cristina and Cavallaro, Giacomo and Decembrino, Nunzia and González, Juan Luis and Lagares, Carolina and Raffaeli, Genny and Smits, Anne and Simons, Sinno P.H. and Villamor, Eduardo and Allegaert, Karel and Garrido, Felipe}, year = {2025}, journal = {European Journal of Pediatrics}, volume = {184}, doi = {10.1007/s00431-025-06074-z}, url = {1947923}, language = {eng}, publisher = {Springer}, keywords = {newborn infant; pain}, abstract = {Purpose This study aims to analyze global prescribing patterns for analgosedation in neonates during four critical care scenarios. The research explores existing patterns, their association with geographic and sociodemographic index (SDI), and adherence to evidence-based practices.Methods Data from a 2024 global survey of 924 responses to 28 questions were analyzed, focusing on four items for their high variability: premedication in intubation (Q17), sedation in preterm (Q19) and full-term newborns (Q23), and perinatal asphyxia (Q26). Latent class analysis (LCA) classified neonatal intensive care unit (NICU) prescriptions into patterns, assigning participants to the most likely class. Demographic variables, including geographic region and SDI, were compared using chi-square tests to assess associations.Results Three distinct prescribing patterns emerged for each scenario. In premedication during intubation, Europe and North America predominantly used Class 1, adhering to guidelines with fentanyl, atropine, and muscle relaxants. In contrast, Class 2, standard in Asia and Latin America-Caribbean, primarily utilized fentanyl and midazolam, with rare use of atropine and muscle relaxants. For analgosedation in newborns, higher-SDI NICUs favored fentanyl, while lower-SDI NICUs preferred midazolam or morphine combinations. In perinatal asphyxia cases, fentanyl was the leading choice in Class 3, especially in Europe. Dexmedetomidine use was limited, primarily appearing in Class 1 NICUs. Conclusion The study highlights substantial regional variability in neonatal analgosedation, influenced by SDI and geography. Despite established guidelines, gaps in evidence-based implementation persist. These findings underscore the need for global standardization of neonatal care protocols and further research on the long-term safety of midazolam and dexmedetomidine. }, issn = {0340-6199} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_arnelllinda_2025, title = {A Historical Overview of the Research Field : Children in Domestic Violence Shelters}, author = {Arnell, Linda and Thunberg, Sara and Källström, Åsa}, year = {2025}, pages = {11--24}, doi = {10.1007/978-3-031-95477-1}, url = {2003072}, language = {eng}, publisher = {Palgrave Macmillan}, abstract = {Research on domestic violence shelters, or refuges, for abused mothers and children is limited, especially research with a focus on children’s lives and living conditions. To make the research that has been done historically visible, this chapter compiles and describes previous research that focused on children with experience of living in domestic violence shelters. The chapter chronologically describes how the field has grown over time and included new research topics and been extended to several different national contexts. The chapter concludes, despite the valuable research that has been done in the field, that it is nevertheless desirable if the field can grow to include new questions and perspectives, to further develop the knowledge regarding children who must flee their home and seek shelter because of violence.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lvezmarabueno_2025, title = {A human pan-disease blood atlas of the circulating proteome}, author = {Álvez, María Bueno and Cajander, Sara and Uhlén, Mathias}, year = {2025}, journal = {Science}, volume = {390}, number = {6779}, doi = {10.1126/science.adx2678}, url = {2005454}, language = {eng}, publisher = {American Association for the Advancement of Science (AAAS)}, abstract = {The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. Here, we present a pan-disease resource to enable the study of diverse disease phenotypes within a harmonized proteomics dataset. By profiling protein concentrations across 59 diseases and healthy cohorts, we identified proteins associated with age, sex, and BMI, as well as disease-specific signatures. This study highlights shared and distinct protein patterns across conditions, demonstrating the power of a unified proteomics approach to uncover biological insights. The dataset, covering 8,262 individuals and up to 5,416 proteins, serves as an online resource for exploring disease-specific protein profiles and advancing precision medicine research.}, issn = {0036-8075} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_kondylivasiliki_2025, title = {A Human-Factors Guided Cognitive Model of Visuospatial Complexity in Embodied Active Vision}, author = {Kondyli, Vasiliki and Suchan, Jakob and Bhatt, Mehul}, year = {2025}, url = {2024313}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_pugliesefrancesca_2025, title = {A just mobility transition? Intersectional responses to car-use reduction measures}, author = {Pugliese, Francesca and Cacace, Marina and Balkmar, Dag and Esteves, Alina and Fonseca, Maria Lucinda and Holman, Andrei and Popusoi, Simona and Sandström, Lina}, year = {2025}, journal = {Local Environment: the International Journal of Justice and Sustainability}, pages = {1--22}, doi = {10.1080/13549839.2025.2596725}, url = {2024732}, language = {eng}, publisher = {Routledge}, keywords = {car-restrictive policies; intersectionality; transport poverty; sustainable urban mobility; exit-voice-loyalty-neglect model; environmental justice}, abstract = {Car-use reduction measures, which either restrict car use or encourage sustainable mobility alternatives, are increasingly promoted to reduce greenhouse gas emissions and improve urban air quality. Yet individual reactions to these interventions often reveal tensions between environmental goals, mobility needs, and perceptions of fairness. Through an intersectional and qualitative lens, this article explores how residents of five European cities in Italy, Norway, Portugal, Romania, and Sweden respond to a range of policies designed to curb car use. Drawing on 54 in-depth interviews with participants from socio-economically disadvantaged neighbourhoods, the study applies an expanded version of Hirschman’s Exit, Voice, and Loyalty framework, incorporating the category of Neglect, to capture active protest, silent disengagement, and supportive behaviours. Findings reveal that reactions to these policies are not solely determined by ideology or single socio-demographic traits, but emerge from the interplay of policy design, lived mobility needs, and the intensity of overlapping vulnerabilities such as caregiving responsibilities, disability, economic stress, and social exclusion. Notably, structural disadvantage can suppress both support and protest, resulting in passive disengagement. By introducing “neglect” as a form of civic reaction and adopting an intersectional approach, the study contributes to a more comprehensive understanding of public policy acceptability and outlines key considerations for achieving a socially just mobility transition.}, issn = {1354-9839} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_engrenjimmy_2025, title = {A local newspaper as mediator in transatlantic networks during the late nineteenth century : Isidor Kjellberg and Östgöten}, author = {Engren, Jimmy and Jarlbrink, Johan}, year = {2025}, journal = {Journalistica}, volume = {19}, number = {1}, pages = {1--25}, doi = {10.7146/journalistica.v19i1.153248}, url = {2010006}, language = {eng}, publisher = {Forlaget Ajour, Royal Danish Library}, keywords = {americanization; computational methods; cut-and-paste journalism; immigrant press; partisan press}, abstract = {As mass migration from Sweden to the USA took off in the late 1860s, texts started to flow between Swedish and Swedish-American newspapers. A network of interconnected papers was established, based on cut-and-paste journalism and journalists moving between the countries. By combining digital text mining and network analysis with a biographical approach, this article examines the role of one specific editor and his paper within the transatlantic exchange system. The analysis shows that Isidor Kjellberg (1841–1895) and his newspaper Östgöten acted as a guide, giving advice and updates on American conditions to Swedes who wanted to migrate. Kjellberg also used the Swedish-American press as an ally in his campaigns for political reform, workers’ rights, and equality, but he also incorporated the methods of American new journalism in his own reporting. The result was not American journalism according to the standard news paradigm, but a hybrid serving his own political agenda.}, issn = {1901-6220}, file = {https://oru.diva-portal.org/smash/get/diva2:2010006/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrklundfilip_2025, title = {A lung function threshold for survival? - FEV1Q and mortality in patients with COPD and chronic respiratory failure}, author = {Björklund, Filip and Palm, Andreas and Sundh, Josefin and Ekström, Magnus}, year = {2025}, journal = {Respiratory Medicine}, volume = {246}, doi = {10.1016/j.rmed.2025.108242}, url = {1982347}, language = {eng}, publisher = {Elsevier}, keywords = {fev(1)q; ltot; mortality}, abstract = {INTRODUCTION: The FEV1 quotient (FEV1Q), calculated as the index between FEV1 and a theoretical lower survivable FEV1 threshold of 0.4L for females and 0.5L for males, has been investigated as a novel method of interpreting results from lung function testing. The applicability of the FEV1Q in populations with chronic respiratory failure has not been studied, and the continuous association between the FEV1Q and mortality is unknown.METHODS: Longitudinal analysis of data from the DISCOVERY database. First percentile values of FEV1 were determined. The predictive ability of FEV1Q and FEV1%-predicted values for overall and respiratory mortality were compared using Cox and Fine-Gray regression models with C-statistics. The continuous association between FEV1Q and mortality was evaluated using a restricted cubic spline.RESULTS: A total of 5,711 patients (61% females) with oxygen-dependent COPD were studied. First-percentile values of FEV1 were 0.3L for females, and 0.4L for males. Higher levels of FEV1Q were associated with a lower risk of overall and respiratory mortality when adjusting for age, sex, height, smoking status, A-a-gradient, and education. For overall mortality, FEV1Q and FEV1%-predicted models had identical C-statistics of 0.60 (95%CI 0.59-0.61). The association between FEV1Q and overall mortality was J-shaped, with a threshold of increased risk at FEV1Q values < 1.0.CONCLUSION: While first-percentile values of FEV1 were lower in this cohort than in previous studies, a population threshold for increased mortality risk was identified at FEV1Q levels corresponding to those originally presented. For individual subjects, neither FEV1Q, nor FEV1%-predicted, were identified as useful predictors of mortality.}, issn = {0954-6111} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrklundfilip_2025_1, title = {A lung function threshold for survival?-FEV1Q and mortality in patients with chronic respiratory failure}, author = {Björklund, Filip and Palm, Andreas and Sundh, Josefin and Ekström, Magnus}, year = {2025}, journal = {European Respiratory Journal}, volume = {66}, number = {Suppl. 69}, doi = {10.1183/13993003.congress-2025.PA2448}, url = {2037519}, language = {eng}, publisher = {European Respiratory Society}, abstract = {Introduction: The FEV1 quotient (FEV1Q), calculated as the index between FEV1 and a theoretical lower survivable FEV1 threshold of 0,4L for females and 0,5L for males, has been investigated as a novel method of interpreting results from lung function testing. The applicability of the FEV1Q in populations with chronic respiratory failure has not been studied, and the continuous association between the FEV1Q and mortality is unknown.Methods: Longitudinal analysis of data from the DISCOVERY database. First percentile values of FEV1 were determined. The predictive ability of FEV1Q and FEV1%-predicted values for overall and respiratory mortality were compared using Cox and Fine-Gray regression models with C-statistics. The continuous association between FEV1Q and mortality was evaluated using a cubic spline.Results: A total of 5,711 patients with oxygen-dependent COPD were studied. First-percentile values of FEV1 were 0.3L for females, and 0.4L for males. Higher levels of FEV1Q were associated with a lower risk of overall and respiratory mortality when adjusting for age, sex, height, smoking status, A-a-gradient, and education level. Both FEV1Q and FEV1%-predicted models had identical C-statistics of 0.60 (95% CI 0.59-0.61). The association between FEV1Q and overall mortality was J-shaped, with a threshold of increased risk at FEV1Q values < 1.0.Conclusion: While first-percentile values of FEV1 were lower in this cohort than in previous studies, a population threshold for increased mortality risk was identified at FEV1Q levels corresponding to those originally presented. For individual subjects, both FEV1Q and FEV1%-predicted had a weak discriminative ability for mortality.}, issn = {0903-1936} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gillischelsia_2025, title = {A multimodal prehabilitation class for Enhanced Recovery After Surgery : a pragmatic randomised type 1 hybrid effectiveness-implementation trial}, author = {Gillis, Chelsia and Hasil, Leslee and Keane, Ciaran and Brassard, Didier and Kiernan, Friede and Bellafronte, Natalia Tomborelli and Culos-Reed, S. Nicole and Gramlich, Leah and Ljungqvist, Olle and Fenton, Tanis R.}, year = {2025}, journal = {British Journal of Anaesthesia}, doi = {10.1016/j.bja.2025.03.001}, url = {1951290}, language = {eng}, publisher = {Elsevier}, keywords = {eras; before surgery; perioperative; pre-rehab; surgery school; universal prehabilitation}, abstract = {BACKGROUND: Prehabilitation promotes postoperative recovery through preoperative optimisation; however, few studies have been conducted under real-world conditions. Our objective was to determine the extent to which a multimodal prehabilitation programme influenced intermediate and late recovery post-colorectal surgery in a type 1 effectiveness-implementation and randomised pragmatic trial. We hypothesised that a prehabilitation class, as part of an Enhanced Recovery After Surgery (ERAS) pathway, would reduce length of hospital stay (LOS).METHODS: Adult male and female patients with colorectal disease requiring an elective primary resection at a single centre were randomised to the intervention or standard care group at least 2 weeks before surgery. All participants attended an ERAS class, which was extended to include prehabilitation components of nutrition education, supplements, walking with a smartwatch, functional exercises, and deep breathing in the intervention group. Effectiveness outcomes included LOS (primary) and 6-min walking distance (6MWD; secondary outcome) at 6 weeks post-surgery. Implementation outcomes included adherence to prescribed step count and nutrient intakes. Multivariable regression analyses were adjusted for age, sex, type of surgery, and COVID-19.RESULTS: The study ended prematurely. In total, 110 patients were included. Two-thirds had cancer and mean prehabilitation duration was 17.2 (sd 5.5) days. LOS was not different between groups. Preoperative median step count did not differ between groups, but protein inadequacy (prevalence ratio: 0.59 [95% CI: 0.36-0.82]) decreased substantially with prehabilitation. After surgery, the mean difference in 6MWD was +38 m (95% CI: 9-67 m) for prehabilitation vs control, indicating earlier functional recovery.CONCLUSIONS: A pragmatic prehabilitation programme did not influence length of hospital stay (underpowered because of early trial termination), but did reduce preoperative protein inadequacy (implementation outcome) and improve early functional recovery (secondary outcome).CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov (NCT04247776).}, issn = {0007-0912} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lundqvistlarsolov_2025, title = {A Norwegian adaptation of the quality in psychiatric care - inpatient staff (QPC-IPS) : psychometric evaluation and staff assessment of quality of care}, author = {Lundqvist, Lars-Olov and Gonzalez, Marianne Thorsen and Moen, Øyfrid Larsen and Skundberg-Kletthagen, Hege and Schröder, Agneta}, year = {2025}, journal = {Nordic Journal of Psychiatry}, volume = {79}, number = {2}, pages = {146--155}, doi = {10.1080/08039488.2025.2461453}, url = {1935534}, language = {eng}, publisher = {Taylor & Francis}, keywords = {psychiatric care; mental healthcare; psychometric evaluation; quality of care; sociodemographic factors; staff; work-related factors}, abstract = {Background: The restructuring and decentralization of psychiatric services in Norway, aligning with global trends, has sparked debate on quality assurance. This study aimed to evaluate the psychometric properties of the Norwegian version of the Quality in Psychiatric Care - Inpatient Staff (QPC-IPS). Additionally, it sought to investigate the sociodemographic and work-related factors associated with staff perceptions of the quality of inpatient psychiatric care that they provide.Material and methods: The Swedish QPC-IPS, a 30-item, 6-dimension tool, was thoroughly translated for the Norwegian psychiatric care setting. A web survey, including the QPC-IPS and sociodemographic and work-related items, was distributed to the mental health staff of two Norwegian health trusts, yielding 117 responses.Results: The adapted version underwent confirmatory factor analysis, revealing a factor structure consistent with the original QPC-IPS and its versions in other languages. Staff generally reported high-quality care, with the highest for the secluded environment and the lowest for the secure environment. Positive associations were found between quality perceptions and factors, such as professional development, openness to quality assurance, and participation in quality work. Psychosocial environments and staff mental health were positively linked to quality-of-care dimensions and the staff recommendations correlated with their perception of patients' experiences of quality of care.Conclusions: The Norwegian QPC-IPS demonstrated adequate psychometric properties, facilitating its use in assessing psychiatric care staff's perception of patients' experiences of quality of care. Insights from staff perspectives contribute to identifying areas for improvement in inpatient psychiatric care, thereby enhancing cross-cultural comparisons and theory development in this domain.}, issn = {0803-9488} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nguyenhoang_2025, title = {A note on the dynamic effects of supply and demand shocks in the crude oil market}, author = {Nguyen, Hoang and Österholm, Pär}, year = {2025}, journal = {Applied Economics Letters}, volume = {32}, number = {11}, pages = {1627--1633}, doi = {10.1080/13504851.2024.2308590}, url = {1837689}, language = {eng}, publisher = {Routledge}, keywords = {bayesian var; time-varying parameters; model selection; oil shocks}, abstract = {In this paper, we investigate whether key relations in the crude oil market have been stable over time. This is done by estimating hybrid time-varying parameter structural Bayesian VAR models using monthly data ranging from February 1973 to May 2023. Model selection suggests that while stochastic volatility is preferred over homoscedasticity, the dynamics of the model are best described by constant parameters in all equations.}, issn = {1350-4851} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tolgforsbjrn_2025, title = {A PE teacher’s tale : journeying from teacher education to teaching practice in physical education}, author = {Tolgfors, Björn and Quennerstedt, Mikael and Backman, Erik and Nyberg, Gunn}, year = {2025}, journal = {Sport, Education and Society}, volume = {30}, number = {1}, pages = {29--41}, doi = {10.1080/13573322.2023.2281389}, url = {1813132}, language = {eng}, publisher = {Routledge}, keywords = {transitions; narrative inquiry; occupational socialisation theory; assessment for learning; physical education teacher education; teaching}, abstract = {As part of a longitudinal research project on the transition from physical education teacher education (PETE) to school physical education (PE) in Sweden and exploring whether and how PETE matters, this article uses narrative inquiry to ‘represent’ a PE teacher’s professional journey from PETE to the induction phase of PE teaching. The study focuses on his use of, and reflections on, ‘assessment for learning’ (AfL) at different stages of his teaching experience. The purpose of the study is to contribute knowledge about how positive experiences of AfL during PETE can enable the use of AfL in school PE for a newly qualified teacher. This is done by analysing one male PETE student’s reflections on AfL in the context of a campus-based course on PE assessment, his use of and reflections on AfL during his practicum, and in school PE as a newly qualified teacher. The data generation consisted of recordings of a PETE seminar, a stimulated recall interview with the participant during his final school placement, and two interviews with him in his role as a newly qualified PE teacher at two different schools. Through the PE teacher’s tale, we show how the campus-based course on PE assessment in PETE and the student teacher’s positive experience of using AfL during his practicum seem to have inspired him in his later positions. The results are discussed in relation to the perspective of occupational socialisation theory. This narrative inquiry suggests that PETE can make a difference for student teachers who are prepared to face the challenges of the induction phase of PE teaching and are able to navigate between the barriers that get in their way. We conclude the paper with some considerations regarding the study’s potential strength (trustworthiness), sharing (transferability) and service (usefulness).}, issn = {1357-3322}, file = {https://oru.diva-portal.org/smash/get/diva2:1813132/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_olssonmax_2025, title = {A pilot study of a deliberate practice intervention for therapist trainees}, author = {Olsson, Max and Gustafsson, Markus and Carlsson, Jan and Rousmaniere, Tony and Bergbom, Sofia and Norberg, Joakim}, year = {2025}, journal = {Nordic Psychology}, volume = {77}, number = {2}, pages = {165--184}, doi = {10.1080/19012276.2024.2313532}, url = {1839274}, language = {eng}, publisher = {Taylor & Francis}, keywords = {deliberate practice; intrapersonal skills; training effect; therapist development; single-case research}, abstract = {Deliberate practice (DP) is well established and widely accepted in expert performance research within a variety of fields. Recently, researchers have started to examine if the same training principles can be applied to psychotherapists. The aim of this study was to examine the impact on intrapersonal skills and the experiences of a six-week DP intervention on seven therapist trainees (n = 7). To do this, a single-case research design was used, combining weekly repeated measurements and pre- and post-intervention measurements as well as a qualitative study analyzed by inductive thematic analysis. The results from our measurements indicate mixed results, where three out of seven participants achieved a significant positive intervention effect and we can see that most participants change in the hypothesized direction on mindful attention (MAAS), experiential avoidance (MEAQ), emotional processing (EPI), and self-compassion (SCS). The participants described gains on increased self-awareness, more compassionate treatment of oneself, increased tolerance of unpleasant feelings as well as a sense of being able to use their own experiences to understand their relationship to other people. The intervention also gave the participants an ability to hold contrasting thoughts and emotions and provided an increased sense of hope for their own future development. The findings of our study should be interpreted in light of its pilot nature and the limited extent of our design. However, it indicates that it seems possible to achieve positive results on intrapersonal skills from a relatively short period of training.}, issn = {1901-2276} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_sdergrenjonatan_2025, title = {A Poetic Model of Otherness in Postcolonial Consumer Acculturation}, author = {Södergren, Jonatan and Vallström, Niklas}, year = {2025}, url = {1978699}, language = {eng}, abstract = {This presentation revits consumer acculturation research through a poetic lens inspired by Édouard Glissant’s Poetics of Relation. Analyzing the Windrush generation in the UK, it reveals how migrants use consumption to poetize relations to Otherness and displacement, offering an alternative to dominant host-centered frameworks in consumer culture theory.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_polfusterjosep_2025, title = {A population-based multigenerational family co-aggregation study of severe infections and obsessive-compulsive disorder}, author = {Pol-Fuster, Josep and Fernández de la Cruz, Lorena and Beucke, Jan and Hesselmark, Eva and Crowley, James J. and de Schipper, Elles and Brikell, Isabell and Chang, Zheng and D'Onofrio, Brian M. and Larsson, Henrik and Lichtenstein, Paul and Kuja-Halkola, Ralf and Mataix-Cols, David}, year = {2025}, journal = {Biological Psychiatry}, volume = {97}, number = {7}, pages = {672--677}, doi = {10.1016/j.biopsych.2024.09.004}, url = {1898842}, language = {eng}, publisher = {Elsevier}, keywords = {ocdtwin study; obsessive-compulsive disorder; pandas; pans; co-aggregation study; cohort study; severe infections}, abstract = {BACKGROUND: Postinfectious autoimmune processes have been proposed as potential causal factors for obsessive-compulsive disorder (OCD). This large population-based study aimed to clarify the co-aggregation pattern between severe infections and OCD across clusters of relatives with varying degrees of relatedness.METHODS: We identified 4,916,898 individuals born in Sweden between 1960 and 2008 and followed them until 2020. Each individual was linked to their first- and second-degree relatives, including monozygotic (MZ) and dizygotic (DZ) twins, mothers, fathers, full siblings, maternal and paternal half siblings, aunts, uncles, and cousins. OCD and infection diagnoses from inpatient and specialized outpatient units were retrieved from the Swedish National Patient Register. We compared the risk of OCD in relatives of probands with severe infections to those of probands without severe infections. Cox proportional hazard regression models, incorporating time-varying exposures, were used to estimate hazard ratios (HRs). Dose-response associations were examined using logistic regression models.RESULTS: Relatives of probands with severe infections exhibited a higher risk of OCD, increasing with genetic relatedness, with HRs (95% CI) ranging from 1.46 (1.07-1.98) in MZ twins to 1.10 (1.09-1.11) in cousins. The results remained robust after adjusting for severe infections among relatives, OCD in probands, and comorbid autoimmune disorders in both probands and relatives. A dose-response association was observed between the number of infections in the probands and their odds of OCD, as well as in their relatives.CONCLUSIONS: The results strongly suggest that the association between severe infections and OCD may be largely driven by shared genetic factors.}, issn = {0006-3223} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_borga_2025, title = {A qualitative comparison of clinical reasoning training : LLM-powered social robotic versus computer-based virtual patients for undergraduate medical education in rheumatology}, author = {Borg, A. and Jobs, B. and Huss, V. and Gentline, C. and Espinosa, F. and Ruiz, M. and Edelbring, Samuel and Georg, C. and Skantze, G. and Parodis, Ioannis}, year = {2025}, journal = {Scandinavian Journal of Rheumatology}, volume = {54}, number = {Suppl. 132}, pages = {302--302}, url = {2016258}, language = {eng}, publisher = {Taylor & Francis}, abstract = {Objective/Background: Integration of virtual patient (VP) cases has traditionally complemented clinical encounters during medical students clinical placements at Karolinska Institutet (KI). This study aimed to assess the educational value of clinical reasoning (CR) training by comparing two platforms: a novel large language model (LLM)-enhanced social robotic VP platform and a conventional computer-based platform within the context of rheumatology.Methods/summary of work: A qualitative study involved 23 third-year medical students from KI during clinical placements in rheumatology. Each student completed nine VP cases using two distinct platforms: an LLM-enhanced social robotic platform and a computer-based semi-linear platform. Following each case completion, students participated in seminars with consultant rheumatologists to discuss the clinical cases. In-depth interviews assessed students’ self-perceived acquirement of CR skills using the two platforms following all VP cases and their corresponding seminars. Thematic analysis was employed to identify themes and sub-themes.Results/Summary of results: Thematic analysis revealed three principal themes: authenticity, VP application, and strengths and limitations. Students perceived the social robotic platform more authentic and engaging, particularly through its capacity for interactive communication and emotional expression, collectively delivering a realistic clinical experience. The platform demonstrated effectiveness in facilitating active learning processes, hypothesis formation, and adaptive thinking skills. However, notable limitations were identified, including the absence of physical examination capabilities and instances of mechanical dialogue patterns.Conclusion: In our setting of undergraduate medical education placements within rheumatology, an LLM-enhanced social robotic VP platform offered a more authentic and interactive learning experience compared to a conventional computer-based platform. Despite some limitations, the social robotic platform shows promise in training CR skills, communication, and adaptive thinking. AI-enhanced Social robotic VPs may prove useful learning modalities for exposing medical students to diverse, highly interactive patient simulations.}, issn = {0300-9742} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_zuidbergdosmartirespedro_2025, title = {A Quantum Information Theoretic Approach to Tractable Probabilistic Models}, author = {Zuidberg dos Martires, Pedro}, year = {2025}, volume = {286}, pages = {3013--3030}, url = {2021344}, language = {eng}, keywords = {probabilistic circuits; tractable models; quantum machine learning}, abstract = {By recursively nesting sums and products, probabilistic circuits have emerged in recent years as an attractive class of generative models as they enjoy, for instance, polytime marginalization of random variables. In this work we study these machine learning models using the framework of quantum information theory, leading to the introduction of positive unital circuits (PUnCs), which generalize circuit evaluations over positive real-valued probabilities to circuit evaluations over positive semi-definite matrices. As a consequence, PUnCs strictly generalize probabilistic circuits as well as recently introduced circuit classes such as PSD circuits. }, file = {https://oru.diva-portal.org/smash/get/diva2:2021344/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nowrooziehsan_2025, title = {A Random Deep Feature Selection Approach to Mitigate Transferable Adversarial Attacks}, author = {Nowroozi, Ehsan and Mohammadi, Mohammadreza and Rahdari, Ahmad and Taheri, Rahim and Conti, Mauro}, year = {2025}, journal = {IEEE Transactions on Network and Service Management}, volume = {22}, number = {6}, pages = {5301--5310}, doi = {10.1109/TNSM.2025.3594253}, url = {2025469}, language = {eng}, publisher = {IEEE}, keywords = {training; resource description framework; data models; vectors; robustness; computational modeling; training data; feature extraction; computer vision; computer architecture; adversarial machine learning; poisoning attacks; backdoor attacks; exploratory attacks; transferability; deep learning; network security}, abstract = {Machine learning and deep learning are transformative forces reshaping our networks, industries, services, and ways of life. However, the susceptibility of these intelligent systems to adversarial attacks remains a significant issue. On the one hand, recent studies have demonstrated the potential transferability of adversarial attacks across diverse models. On the other hand, existing defense mechanisms are vulnerable to advanced attacks or are often limited to certain attack types. This study proposes a random deep feature selection approach to mitigate such transferability and improve the robustness of models against adversarial manipulations. Our approach is designed to strengthen deep models against poisoning (e.g., label flipping) and exploratory (e.g., DeepFool, BIM, FGSM, I-FGSM, L-BFGS, C&W, JSMA, and PGD) attacks that are applied in both the training and testing stages, and Transfer Learning-Based Adversarial Attacks. We consider scenarios involving perfect and semi-knowledgeable attackers. The performance of our approach is evaluated through extensive experiments on the renowned UNSW-NB15 dataset, including both real-world and synthetic data, covering a wide range of modern attack behaviors and benign activities. The results indicate that our approach boosts the effectiveness of the target network to over 80% against label-flipping poisoning attacks and over 60% against all major types of exploratory attacks.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zhaiqiwei_2025, title = {A randomized controlled trial of supervised group exercise therapy in patients with clinical depressive and anxiety disorders : the challenge of patient compliance}, author = {Zhai, Qiwei and Folkesson, Mattias and Hörnsten, C. and Persson, Jonas and Montgomery, Scott and Freund-Levi, Yvonne}, year = {2025}, journal = {European psychiatry}, volume = {68}, number = {Suppl. 1}, pages = {S129--S130}, doi = {10.1192/j.eurpsy.2025.352}, url = {2016232}, language = {eng}, publisher = {Cambridge University Press}, issn = {0924-9338} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stabyolsnjohan_2025, title = {A Randomized Trial on Accelerated Versus Standard Small-margin Radiation Schedule in Patients With Prostate Cancer Treated With Combined Brachytherapy and External Beam Radiation Therapy : Toxicity Outcomes and Patterns of Prostate Movement}, author = {Staby Olsén, Johan and Valachis, Antonis and Johansson, Bengt}, year = {2025}, journal = {Advances in radiation oncology}, volume = {10}, number = {4}, doi = {10.1016/j.adro.2025.101737}, url = {1948840}, language = {eng}, publisher = {Elsevier}, abstract = {PURPOSE: Hypofractionated radiation therapy requires high accuracy in dose delivery to enable reduced treatment margins and minimize the dose to organs-at-risk. The purpose of this study was to evaluate whether accelerated (delivered 5 times per week) hypofractionated external beam radiation therapy (EBRT) can be performed without increased acute toxicity using a real-time tracking system. We also aimed to investigate patterns of intrafractional prostate movements.METHODS AND MATERIALS: Patients with prostate cancer planned for combined high dose rate brachytherapy (14.5 Gy × 1) and EBRT (3 Gy × 14) were included in this randomized trial to receive the EBRT part of the treatment either 3 or 5 times per week. EBRT was delivered using small margins (3 mm) using the Raypilot system for real-time tracking of intrafractional prostate movements. Movements were continuously monitored in 3 dimensions. Primary endpoint was toxicity that was assessed using patient-reported outcome measures through european organisation for research and treatment of cancer (EORTC) quality of life questionnaires QLQ-C30 and QLQ-PR25.RESULTS: During June 2018 to January 2020, 34 patients (median age 70 years) were included in the study of which 17 were randomized to each group. No statistically significant differences in toxicity were found between the study groups. Target displacement was <2 mm during 97.0% of the time and <3 mm during 99.9% of the active treatment time.CONCLUSIONS: We found no evidence of increased acute toxicity in patients who received accelerated treatment schedule. Provided that the target is properly delineated, a 3 mm margin seems to be feasible and safe when using a real-time tracking system.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_westergrenalbert_2025, title = {A Rasch model based psychometric evaluation of different versions of the Minimal Insomnia Symptom Scale (MISS) among adults}, author = {Westergren, Albert and Hedin, Gita and Hagell, Peter and Bäccman, Charlotte and Norell, Annika}, year = {2025}, journal = {Sleep Science and Practice (SSP)}, volume = {9}, number = {1}, doi = {10.1186/s41606-025-00131-0}, url = {2031446}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {clinical insomnia; invariant comparisons; miss; prevalence; psychometric properties; rash measurement model; reliability; screening; targeting}, abstract = {Background: Insomnia is a common health complaint among adults and is associated with poor health. Sleeping patterns differ due to age, with younger adults having greater problems with sleep deprivation causing problems during daytime, and older adults having greater problems with nocturnal awakenings during nights. Screening tools are needed to initially capture insomnia symptoms in need for further assessment. The study aim was to psychometrically test and compare the original three item Minimal Insomnia Symptom Scale (MISS), revised version of MISS (MISS-R), and a four-item scale (MISS-4) on an adult population, by using the Rasch measurement model.Methods: A cross-sectional design was used, and the sample consisted of participants in an online survey of a Citizen Panel. Out of the total sample (N = 1517), 784 (52%) persons with answers on four sleep items, age, and gender were included in this study. The majority of the sample were men (n = 536), 248 were women, and 52% were younger (16–59 years). Rasch model analyses focused on targeting, reliability, response category functioning, model fit, differential item functioning (DIF) and score transformation.Results: The MISS and the MISS-R had good measurement properties. When adding the item “daytime disturbance” to the MISS, and creating MISS-4, the measurement properties deteriorated. When replacing the original MISS item “not rested by sleep” with the item “daytime disturbance” in the MISS-R, the measurement properties maintained like those of the MISS. There were, as expected, DIF between the younger (below 60 years) and older samples (60 years or older) in insomnia symptoms. The reliability for the MISS was 0.58 and the MISS-R 0.57.Conclusions: The MISS and the MISS-R demonstrate good measurement properties as insomnia screening questionnaires. When using either the MISS or the MISS-R to identify potential insomnia, a ≥ 6 cut-off seems to be most appropriate. While psychometrically supported, determination of the optimal cut-score for clinical insomnia identification should consider gold standard diagnostic criteria in future studies.}, file = {https://oru.diva-portal.org/smash/get/diva2:2031446/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zhangshiyu_2025, title = {A Receding Horizon Online Trajectory Generation Method for Time-Efficient Path Tracking with Dynamic Factors}, author = {Zhang, Shiyu and Sun, Da and Liao, Qianfang}, year = {2025}, journal = {IEEE/ASME transactions on mechatronics}, volume = {30}, number = {5}, pages = {3277--3288}, doi = {10.1109/TMECH.2024.3477006}, url = {1912030}, language = {eng}, publisher = {IEEE}, keywords = {autonomous robots; collision avoidance; motion planning; trajectory optimization}, abstract = {Current path-tracking trajectory planning methods intrinsically suffer from a heavy computational burden, hindering them from modern autonomous robotic applications requiring real-time reactivity. To achieve flexible, accurate, and efficient motions, this article proposes a real-time trajectory planning framework for time-efficient path tracking. First, a receding horizon method is designed that generates local trajectories online while considering the global kinematic constraints. Second, an analytical closed-form method is developed for calculating the local time-minimal trajectory. Third, the models and solutions are established for handling dynamic factors. Compared to existing methods, this method exhibits lower computational complexity and can deal with path changes during motion executions while maintaining tracking accuracy and time efficiency. Experiments using Franka-Emika Panda robots are conducted in handover scenarios involving unpredictable dynamic obstacles and human interventions. The results demonstrate the low computational overhead. The robot flexibly reacts to online path changes, maintaining tracking accuracy while marginally compromising time efficiency.}, issn = {1083-4435} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_noppaerik_2025, title = {A retrospective cohort of smartpilot view-assisted effect-site TCI anaesthesia in primary total hip and knee arthroplasty}, author = {Noppa, Erik and Persson, Alexander and Öhrström, Henrik and Wretenberg, Per and Lundqvist, Eva}, year = {2025}, journal = {BMC Anesthesiology}, volume = {25}, number = {1}, doi = {10.1186/s12871-025-03471-7}, url = {2014191}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {anaesthesia outcomes; enhanced recovery after surgery (eras); perioperative care; postoperative nausea and vomiting (ponv); postoperative recovery; target-controlled infusion; total hip arthroplasty; total knee arthroplasty}, abstract = {Background: Primary total hip arthroplasty and total knee arthroplasty are common surgical procedures that require effective perioperative care to ensure early mobilisation, reduced complications, and shortened hospital stay. Effect-site target-controlled infusion (TCI) combined with SmartPilot View (SPV) is a novel approach to total intravenous anaesthesia that may improve anaesthetic precision and reduce postoperative side effects. However, it has not been thoroughly evaluated in joint arthroplasty. The aim of this study was to evaluate the early anaesthetic outcomes in hip and knee arthroplasty patients following the implementation of effect-site TCI and SPV.Methods: We conducted a retrospective cohort study including 2316 procedures (2210 patients) at & Ouml;rebro University Hospital, Lindesberg, Sweden, between 2018 and 2023. Two groups were compared: pre-implementation (2018-2019, n = 1258) using plasma-targeted TCI without SPV, and post-implementation (2022-2023, n = 1058) using effect-site TCI with SPV. Patients from 2020 to 2021 were excluded due to the COVID-19 pandemic and the overlap of methods during implementation. Data were extracted from the Swedish Perioperative Register. The primary outcome was the incidence of postoperative nausea and vomiting (PONV). Secondary outcomes included length of stay in the post-anaesthesia care unit (phase II), postoperative pain, and surgical duration.Results: PONV incidence decreased significantly from 8.4% to 3.0% after implementation (p < 0.001; adjusted OR: 0.36, 95% CI: 0.23-0.55). Median post-anaesthesia care unit stay decreased by 70 min (95% CI: 61-78 min; p < 0.001). Postoperative pain scores were slightly lower in the post-implementation group (median numeric rating scale 7 vs. 5; p < 0.001). Surgical duration increased marginally (84 vs. 87 min; p = 0.003).Conclusions: Implementation of effect-site TCI and SPV in hip and knee arthroplasty was associated with significantly reduced PONV and shorter post-anaesthesia care unit stay, suggesting improved early postoperative recovery.Clinical trial number: Not applicable.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_araizaillandejanira_2025, title = {A Roadmap for Responsible Robotics : Promoting Human Agency and Collaborative Efforts}, author = {Araiza-Illan, Dejanira and Baum, Kevin and Beebee, Helen and Chatila, Raja and Moth-Lund Christensen, Sarah and Coghlan, Simon and Collins, Emily and Conroy, S. Kate and Cunha, Alcino and Dobrosovestnova, Anna and Duijf, Hein and Evers, Vanessa and Fisher, Michael and Hochgeschwender, Nico and Kökciyan, Nadin and Lemaignan, Séverin and Rodriguez-Lera, Francisco and Ljungblad, Sara and Magnusson, Martin and Mansouri, Masoumeh and Milford, Michael and Moon, Ajung and Powers, Thomas M. and Salvini, Pericle and Scantamburlo, Teresa and Schuster, Nick and Slavkovik, Marija and Topcu, Ufuk and Vanegas, Daniel and Wasowski, Andrzej and Yang, Yi}, year = {2025}, journal = {IEEE robotics & automation magazine}, volume = {32}, number = {4}, pages = {12--24}, doi = {10.1109/MRA.2025.3620148}, url = {2017727}, language = {eng}, publisher = {IEEE}, keywords = {robots; robot sensing systems; service robots; safety; stakeholders; automation; philosophical considerations}, abstract = {This document presents the outcomes of the Dagstuhl Seminar "Roadmap for Responsible Robotics," held in September 2023 at the Leibniz Center for Informatics, Schloss Dagstuhl, Germany. The seminar brought together researchers from the fields of robotics, computer science, social and cognitive sciences, and philosophy with the aim of charting a path toward improving responsibility in robotic systems. Through intensive interdisciplinary discussions centered on the various values at stake as robotics increasingly integrates into human life, the participants identified key priorities to guide future research and regulatory efforts. The resulting road map outlines actionable steps to ensure that robotic systems coevolve with human societies, promoting human agency and humane values rather than undermining them. Designed for diverse stakeholders-researchers, policy makers, industry leaders, practitioners, nongovernmental organizations (NGOs), and civil society groups-this road map provides a foundation for collaborative efforts toward responsible robotics.}, issn = {1070-9932} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_garciaambrosianikarin_2025, title = {A small step for digitalisation, a giant leap for humanity? Reflections on human-centredness in the public sector}, author = {Garcia Ambrosiani, Karin and Skargren, Fredric}, year = {2025}, doi = {10.6027/temanord2025-554}, url = {1977969}, language = {eng}, publisher = {Nordic Council of Ministers}, keywords = {digital government; human-centric; ai; public services; innovation; governance}, abstract = {The concept of human-centredness is frequently used within strategies and expectations in the field of digitalisation. But what does it really mean, and what does putting humans at the centre entail? We aim to highlight different perspectives of these questions and reflect on the various components of human-centredness.What does it mean for the public sector to be human-centric? There are many expectations in this area from international organisations, as well as from Nordic and Baltic countries, where initiatives are underway clearly aimed at achieving a human-centric public sector.In this report, we reflect on the concept from three different dimensions: governance, public services and innovation. We consider how these dimensions are interconnected and the challenges involved. What role does politics play in promoting human-centric governance? How can and should priorities be set from a human-centric perspective? What are the limits and possibilities for public administration to work in a human-centric way? Our aim is not to provide ready made answers but to encourage questions and discussions – alongside decision makers, practitioners, researchers, and others with an interest in the topic.}, file = {https://oru.diva-portal.org/smash/get/diva2:1977969/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_witteerik_2025, title = {A Swedish Sign Language Database of Video-Recorded Sign-Pseudosign Pairs With Matching Neighborhood Density and Phonotactic Probability}, author = {Witte, Erik and Björkstrand, Thomas and Schönström, Krister and Danielsson, Henrik and Holmer, Emil}, year = {2025}, journal = {Journal of Speech, Language and Hearing Research}, volume = {68}, number = {7}, pages = {3291--3304}, doi = {10.1044/2025_JSLHR-24-00761}, url = {1981270}, language = {eng}, publisher = {American Speech-Language-Hearing Association}, abstract = {PURPOSE: The purpose of the current study was to create a set of video-recorded real-sign-pseudosign pairs for Swedish Sign Language (Svenskt teckenspråk, STS). The pseudosigns should be based on the overall phonotactic structures of STS; each real-sign-pseudosign pair should be matched in terms of neighborhood density (ND) and phonotactic probability (PP); the real signs and pseudosigns should have similar distributions of ND, PP, and duration; and the set as a whole should have distributions of ND, PP, and (for the real signs) sign frequency (SF) similar to that of the STS. To achieve this, a secondary purpose was to develop algorithms to calculate ND and PP for STS and to investigate how the metrics correlate.METHOD: Based on publicly available data sources for STS, an initial data set was formed, which was utilized in an automatic algorithm to generate phonotactically feasible pseudosign candidates, as well as to calculate ND and PP values for both the real signs and the generated pseudosign candidates. The use of an automatic matching algorithm was followed by manual evaluation of the selected pseudosign candidates. The selected matching pairs of signs and pseudosigns were video recorded by four actors (two males and two females). RESULTS: Four hundred sixty-six sign-pseudosign pairs, matching in ND and PP, were video-recorded. The real signs and pseudosigns had similar distributions of ND, PP, and duration, and the distributions of ND, PP, and SF values in the recorded set were similar to those of the STS as a whole.CONCLUSIONS: The resulting data set has been made publicly available and is suitable for use in psycholinguistic experiments involving STS. The present work presents a new standard for estimation of lexical metrics in sign language that can be applied to other sign languages than STS in future studies.SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.29318822.}, issn = {1092-4388} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_schubringastrid_2025, title = {A Systematic Scoping Review of the Social Dimensions : A Systematic Scoping Review of the Social Dimensions}, author = {Schubring, Astrid and Bergentoft, Heléne and Caspers, Andreas and Jaczina, Kristof and Lundvall, Suzanne and Jacobsson, Jenny and Barker-Ruchti, Natalie and Gojanovic, Boris and Lindsey, Iain and Loland, Sigmund and Pill, Shane and Bjørndal, Christian Thue and Wals, Arjen and Østergaard Nielsen, Rasmus and Hausken‐Sutter, Solveig Elisabeth and Sevdalis, Vassilis and Grau, Stefan}, year = {2025}, journal = {Sustainable Development}, volume = {33}, number = {5}, pages = {7575--7590}, doi = {10.1002/sd.3526}, url = {1961849}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {elite youth sports; multidisciplinary; social sustainability; sustainable development and sdgss; ystematic review}, abstract = {Sports have been identified as an important contributor to social sustainability, and the benefits for health, well-being, and social learning in young people are well evidenced. Youth elite sports, however, have been criticized as being unsustainable. Following calls for a more socially sustainable development of youth elite sports, research on the topic has increased. However, studies vary in disciplinary origin, concepts, content, and methodology. The aim of this systematic scoping review is to identify and synthesize the current disciplinary research knowledge. Five disciplinary databases were searched. Based on six eligibility criteria and a double-blind review process, a total of 99 articles were selected. Findings were first charted in tables and then examined using descriptive statistics and thematic analysis. Key findings are that there is a lack of conceptual clarity regarding social sustainability, and that the field of study is multidisciplinary with distinct thematic research areas (athlete development, athlete health and well-being, athlete development environment). Most research focuses on athlete-related micro aspects and less on organizational and societal dimensions. Inequity issues were found regarding social diversity, including an overrepresentation of soccer and men's sports. Furthermore, mostly quantitative methodologies are used. A theoretically based and empirically tested understanding of social sustainability is needed as well as research addressing aspects of holistic youth development. Attention should be paid to contextual and macro-level influences. Knowledge about preventive programs and practices that advance social sustainability in youth elite sports is necessary. Organizational conditions and funding programs should be created to increase trans- or multidisciplinary research.}, issn = {0968-0802} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_andrndaniela_2025, title = {A Tall Story? Driver Height and Traffic Fatalities}, author = {Andrén, Daniela and Bossi, Luca and Gumus, Gulcin}, year = {2025}, url = {2003695}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_drinsvitlana_2025, title = {A test on the location of tangency portfolio for small sample size and singular covariance matrix}, author = {Drin, Svitlana and Mazur, Stepan and Muhinyuza, Stanislas}, year = {2025}, journal = {Modern Stochastics: Theory and Applications}, volume = {12}, number = {1}, pages = {43--59}, doi = {10.15559/24-vmsta261}, url = {1888576}, language = {eng}, publisher = {VTeX, Vilniaus Universitetas}, keywords = {tangency portfolio; hypothesis testing; singular wishart distribution; singular covariance matrix; moore–penrose inverse; high-dimensional asymptotics}, abstract = {The test for the location of the tangency portfolio on the set of feasible portfolios is proposed when both the population and the sample covariance matrices of asset returns are singular. The particular case of investigation is when the number of observations, n, is smaller than the number of assets, k, in the portfolio, and the asset returns are i.i.d. normally distributed with singular covariance matrix Σ such that rank(Σ) = r < n < k + 1. The exact distribution of the test statistic is derived under both the null and alternative hypotheses. Furthermore, the high-dimensional asymptotic distribution of that test statistic is established when both the rank of the population covariance matrix and the sample size increase to infinity so that r/n → c ∈ (0, 1). Theoretical findings are completed by comparing the high-dimensional asymptotic test with an exact finite sample test in the numerical study. A good performance of the obtained results is documented. To get a better understanding of the developed theory, an empirical study with data on the returns on the stocks included in the S&P 500 index is provided.}, issn = {2351-6046} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_drinsvitlana_2025_1, title = {A test on the location of tangency portfolio for small sample size and singular covariance matrix}, author = {Drin, Svitlana and Mazur, Stepan and Muhinyuza, Stanislas}, year = {2025}, journal = {Modern Stochastics: Theory and Applications (MSTA)}, volume = {12}, number = {1}, pages = {43--59}, doi = {10.15559/24-vmsta261}, url = {2029508}, language = {eng}, publisher = {VTeX, Vilniaus Universitetas}, keywords = {tangency portfolio; hypothesis testing; singular wishart distribution; singular covariance matrix; moore-penrose inverse; high-dimensional asymptotics}, abstract = {The test for the location of the tangency portfolio on the set of feasible portfolios is proposed when both the population and the sample covariance matrices of asset returns are singular. The particular case of investigation is when the number of observations, n, is smaller than the number of assets, k, in the portfolio, and the asset returns are i.i.d. normally distributed with singular covariance matrix Sigma such that rank(Sigma) = r < n < k + 1. The exact distribution of the test statistic is derived under both the null and alternative hypotheses. Furthermore, the high-dimensional asymptotic distribution of that test statistic is established when both the rank of the population covariance matrix and the sample size increase to infinity so that r/n -> c is an element of (0, 1). Theoretical findings are completed by comparing the high-dimensional asymptotic test with an exact finite sample test in the numerical study. A good performance of the obtained results is documented. To get abetter understanding of the developed theory, an empirical study with data on the returns on the stocks included in the S&P 500 index is provided.}, issn = {2351-6046} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tynikristiina_2025, title = {A thematic analysis of the experiences of prepubertal transgender and gender-diverse children in Sweden}, author = {Tyni, Kristiina and Wurm, Matilda and Sofia Bratt, Anna}, year = {2025}, journal = {Journal of LGBT Youth}, volume = {22}, number = {3}, pages = {466--489}, doi = {10.1080/19361653.2024.2347957}, url = {1856551}, language = {eng}, publisher = {Haworth Press}, keywords = {transgender; children and youth; gender diverse; gender identity; thematic analysis}, abstract = {Knowledge of prepubertal transgender and gender diverse (TGD) children is limited. This study fills a gap in the research literature by exploring the lived experiences of prepubertal TGD children related to gender identity, centering their voices. Interviews with 10 TGD Swedish children 4–12 years old were analyzed through Thematic Analysis. The analysis resulted in two main themes: (1) “The journey of gender exploration,” with subthemes Discovering me and The joys, and challenges of being me; (2) “Meeting the outside world,” with subthemes Can I belong? and Staying me: my tips, tricks and help from others. The children’s evolving gender identity was traced, emphasizing emotional aspects and pivotal milestones like affirmed names. Even though the children had supportive environments, challenges of misgendering and the need for continual self-assertion were exposed. Despite struggles for recognition, the study highlights TGD children’s resilient coping and well-being. Still, cisgender norms were observed to challenge their prevalent pride and positive self-images, emphasizing the need for enhanced knowledge of gender diversity for a broader societal change. This study expands the literature on TGD children’s gender identity development, informs professionals and abroad audience and provides an enhanced understanding of TGD prepubertal children through their own words.}, issn = {1936-1653}, file = {https://oru.diva-portal.org/smash/get/diva2:1856551/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_moodyzoe_2025, title = {A theory of children's human rights education}, author = {Moody, Zoe and Gawlicz, Katarzyna and Gillett-Swan, Jenna and Perry-Hazan, Lotem and Quennerstedt, Ann}, year = {2025}, journal = {European Educational Research Journal}, doi = {10.1177/14749041251378172}, url = {1998963}, language = {eng}, publisher = {Sage Publications}, keywords = {children’s rights; children’s human rights; human rights education; student; teacher; content; educational processes; aims of education}, abstract = {Children’s entitlement to education about their human rights is affirmed by various United Nations treaties and emphasised in scholarly literature. However, the field of rights education for children is hindered by fragmented research and inconsistent terminology, resulting in conceptual confusion that obstructs the development of effective rights education practices. This article tackles these challenges by presenting an innovative theory of Children’s Human Rights Education (CHRE) along with a systemic model. By integrating principles from children’s rights, human rights education, and insights into educational processes, the CHRE theory presents a systemic framework that consists of six interconnected components: aims, ends-in-view, the learner, the educator, content and educational processes. This article outlines the development process and interdisciplinary foundations of the CHRE theory and presents a visual systemic model along with a detailed explanation of each of its six components. The conclusion assesses the theory’s contributions, emphasising its potential to promote conceptual clarity for scholars and practitioners, fostering a more comprehensive and impactful approach to CHRE. The theory also holds the potential to identify research gaps and point to several new research paths, ultimately enhancing the effectiveness of CHRE in supporting children to learn about, through and for their human rights.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_berntorpkarolina_2025, title = {A Vessel-Specific Analysis of Deferred Lesions Using the Instantaneous Wave-Free Ratio and Fractional Flow Reserve}, author = {Berntorp, Karolina and Mohammad, Moman A. and Koul, Sasha and Yndigegn, Troels and Fröbert, Ole and Myredal, Anna and Persson, Jonas and Erlinge, David and Götberg, Matthias}, year = {2025}, journal = {Journal of the Society for Cardiovascular Angiography & Interventions}, volume = {4}, number = {9}, doi = {10.1016/j.jscai.2025.103823}, url = {2003827}, language = {eng}, publisher = {Elsevier}, keywords = {coronary blood flow; left coronary artery; right coronary artery}, abstract = {BACKGROUND: Physiologically guided revascularization improves clinical outcomes. The cutoff values for deferral with fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are the same across all coronary arteries, despite differences in coronary flow patterns. The objective was to compare deferral rates using either FFR or iFR in the right coronary artery (RCA), left anterior descending artery (LAD), and left circumflex artery (LCx), and compare clinical outcomes in deferred lesions in the RCA, LAD, and LCx.METHODS: Right coronary artery, LAD, and LCx lesions in the Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies registry that were evaluated using either FFR or iFR were included. The composite of major adverse cardiac events (MACE) within 5 years and the individual components of cardiovascular death, noncardiovascular death, myocardial infarction, target segment revascularization, and target vessel revascularization were analyzed.RESULTS: In total, 33,241 lesions were included in the final analysis (RCA, 17.8%; LAD, 62.3%; and LCx, 19.9%). The median follow-up time was 3.4 years. The median age was 69 years, and 73.5% of patients were men. The deferral rates with iFR were 10.6% higher (P < .001) in all coronary arteries combined, 18.7% higher (P < .001) in the RCA, 9.5% higher in the LAD (P < .001), and 5.3% higher in the LCx (P = .007). No significant differences were observed in the MACE rate or its individual components at 5 years between the deferred FFR and iFR groups in any of the investigated vessels.CONCLUSIONS: Instantaneous wave-free ratio demonstrated a higher deferral rate across all coronary arteries than those examined with FFR, which was especially pronounced in the RCA, without any associated increased risk of MACE.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bckmalin_2025, title = {A way of relating to life; myself and others - a thematic analysis of patients' experience of having an eating disorder}, author = {Bäck, Malin and Gustafsson, Sanna Aila and Jacobson, Karin and Ljung, Theresia and Holmqvist, Rolf and Andersson, Gerhard}, year = {2025}, journal = {Journal of Eating Disorders}, volume = {13}, number = {1}, doi = {10.1186/s40337-025-01291-1}, url = {1964560}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {eating disorder; patient perspective; lived experience; qualitative study; ego-syntonicity; self-observation; externalization}, abstract = {Background: Eating disorders are psychiatric conditions that extend beyond concerns with weight, body and shape, encompassing complex issues related to self-esteem, emotion regulation and interpersonal functioning. Moreover, co-occurring depression, often undiagnosed, is a common complicating factor. Gaining an in-depth understanding of living with an eating disorder is vital both theoretically and for identifying factors that maintain or inhibit recovery. Patient-centred studies offer valuable insights into the lived experience of eating disorders, highlighting their impact and interaction with various life phenomena.Methods: This qualitative study aimed to capture the meaning and experience of living with an eating disorder from a patient perspective. Semi-structured interviews were conducted with 15 women suffering from eating disorders and comorbid depressive symptoms, prior to the start of treatment. Data were analysed using reflexive thematic analysis.Results: Two dimensions of relating to the eating disorder emerged. The first dimension, "Relating to the eating disorder over time", followed a temporal trajectory with four themes: "The eating disorder as a way to handle other difficulties", "From control to a consistent loss of control", "The whole existence revolves around the eating disorder" and "Hard to see a life without the eating disorder". The second dimension, "Having an eating disorder- a relentless relating", focused on the present experience and was divided into two themes: "The eating disorder's impact on relating to myself" and "The eating disorder's impact on relating to others".Conclusions: Living with an eating disorder involves a constant, entangled and conflicted relationship with the disorder, leading to alienation from significant others and one's own body. This pervasive presence of disordered thoughts and behaviours makes it challenging to relate to oneself and the external world without their influence. Over time, the disorder becomes increasingly ego-syntonic, rendering it difficult to envisage a life without it. Treatment should, therefore, aim to externalise the disorder-to foster new life goals, enhance social engagement, and improve interpersonal skills. Further research is needed to elucidate how co-occurring depressive symptomatology influences an individual's relationship with their eating disorder, as these factors may be crucial in tailoring effective interventions.Plain English Summary: To capture the meaning and experience of living with an eating disorder from the patient's perspective, 15 women with eating disorders and depressive symptoms were interviewed before treatment. Reflexive thematic analysis was used to analyse the data. Two main dimensions of relating to the eating disorder were identified. The first dimension, "Having an eating disorder - a relentless relating," described the present experience and included themes about how the disorder affects their relationships with themselves and others. The second dimension, "Relating to the eating disorder over time," followed a timeline with themes showing how the disorder evolved from a coping strategy to a pervasive force affecting their entire existence. Living with an eating disorder means constantly experiencing a chaotic relationship with the disorder that distances individuals from others and their own bodies, making it challenging to imagine life without the disorder. Treatment should help individuals see the disorder as separate from themselves, reconnect with their bodies, and acknowledge their needs. It should also foster new life goals, social engagement, and improved interpersonal skills for a meaningful life beyond the eating disorder. Further research is needed to understand how depressive symptoms influence the experience of living with an eating disorder and the recovery process, as these factors may be crucial in tailoring effective interventions.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hrertalm_2025, title = {Abdominal Compartment Syndrome After Endovascular Repair of Ruptured Abdominal Aortic Aneurysms : A Single-Center Experience of Total Endovascular Care for Ruptured Abdominal Aneurysms}, author = {Hörer, Tal M. and Abu-Zidan, Fikri M. and McGreevy, David and Nilsson, Kristofer F. and Gidlund, Khatereh Djavani}, year = {2025}, journal = {Journal of Endovascular Therapy}, doi = {10.1177/15266028251328494}, url = {1949317}, language = {eng}, publisher = {Sage Publications}, keywords = {abdominal aortic aneurysm; abdominal compartment syndrome; aortic aneurysm; aortic rupture; complications after aortic surgery; endovascular aortic repair; endovascular procedures}, abstract = {OBJECTIVE: Open repair of ruptured abdominal aortic aneurysms (rAAA) has been increasingly replaced by endovascular aortic repair (EVAR) in many centers. Despite being a minimally invasive procedure, EVAR is associated with a risk of abdominal compartment syndrome (ACS), which can lead to significant morbidity and mortality. This study examines the incidence and clinical manifestation of ACS in a consecutive cohort of rAAA patients treated exclusively with EVAR at Örebro University Hospital over a 12-year period.METHODS: This is a retrospective analysis of prospectively collected data. We identified 139 patients who had presented to Örebro University Hospital with rAAA between October 2009 and September 2021. Patients with isolated iliac artery, thoracic and thoracoabdominal aortic ruptures, previous aortic interventions (open or endovascular), and patients receiving palliative treatment were excluded. Patients developing ACS after rAAA were compared with those who did not develop ACS.RESULTS: A total of 100 patients treated using EVAR were included in this study. ACS was identified in 17 patients, and these were compared with 83 patients who did not develop ACS. Mortality at 30 days was 53% in the ACS group (9/17) and 22% in the No-ACS group (18/83, p = 0.015). Regression analysis showed that advanced age and ACS were independent risk factors for death, with ACS increasing the hazard 4-fold (HR 4.26, CI 1.99-9.10, p < 0.001) and age increasing the hazard by 6% for every year (HR 1.06, CI 1.06-1.1, p = 0.004). The use of aortic balloon occlusion was not independently associated with the development of ACS.CONCLUSIONS: ACS is a life-threatening complication of rAAA treated using EVAR and a significant number of patients developed ACS with high mortality and complication rates. All rAAA patients treated using EVAR should be monitored closely for ACS and treatment with decompressive laparotomy should be initiated without delay.Clinical ImpactOpen repair of ruptured abdominal aortic aneurysms (rAAA) has been increasingly replaced by endovascular aortic repair (EVAR). Despite being a minimally invasive procedure, EVAR is associated with a risk of abdominal compartment syndrome (ACS), which can lead to significant morbidity and mortality This article investigates abdominal compartment syndrome (ACS) in a cohort of total endovascular treated rAAA in a single centre and the treatment as well as the results, and gives insight on ACS in this patient group and might contribute to better understanding how to treat them and avoid this life-threatening complication.}, issn = {1526-6028} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_erikssonlinda_2025, title = {Academic reading in crisis? Looking past the blame game in Swedish higher education}, author = {Eriksson, Linda and Malmström, Hans}, year = {2025}, pages = {21--22}, url = {1951608}, language = {eng}, abstract = {The use of English in Swedish higher education has increased significantly in recent years (Malmström & Pecorari, 2022). This shift is particularly evident in the domain of assigned academic reading. In many disciplines, English texts are now as common as, or even more common than, Swedish texts, even in courses where Swedish is the official language of instruction (Malmström & Pecorari, submitted). This widespread reliance on English should be considered in light of reports indicating that many university students in Sweden, especially at undergraduate level, struggle to read and comprehend their assigned reading in English (see, e.g., Eriksson, 2023). In this paper, we introduce new research evidence offering further insights into students’ academic reading. We present the results of a national survey with students conducted in January 2025 in collaboration with Språkrådet. The survey, which was based on a representative sample of 1,000 students, explored students’ general views on and engagement with academic reading in English and Swedish. Additionally, respondents were asked about how well their previous education had prepared them to read academic texts in these two main languages. Descriptive and inferential statistics are used to analyze and present the quantitative data, which include the variables age, gender, academic discipline, and level of study. Additionally, interview data collected from twelve first-year university students complement the survey findings and help to contextualize and explain the survey data. The interviews, analyzed using qualitative content analysis, explored students’ expectations about required reading at university, focusing on their reading experiences and perceptions of who is responsible for preparing them for academic reading. In our discussion, we situate the findings (currently still under analysis) within the ongoing debate about a “reading crisis” in Swedish higher education and highlight how research of this nature can add important nuance to the debate and provide an important foundation for continued research. The discussion also emphasizes the importance of shared responsibility(ies) among educators, policymakers, and institutions at all levels of education in ensuring equal opportunities for all students to be adequately prepared for academic reading in higher education.  } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fiorinogionata_2025, title = {Accelerating Earlier Access to Anti-TNF-α Agents with Biosimilar Medicines in the Management of Inflammatory Bowel Disease}, author = {Fiorino, Gionata and Ananthakrishnan, Ashwin and Cohen, Russell D. and Cross, Raymond K. and Deepak, Parakkal and Farraye, Francis A. and Halfvarson, Jonas and Steinhart, A. Hillary}, year = {2025}, journal = {Journal of Clinical Medicine}, volume = {14}, number = {5}, doi = {10.3390/jcm14051561}, url = {1946352}, language = {eng}, publisher = {MDPI}, keywords = {crohn’s disease; anti-tnf-?; biosimilar; early treatment; inflammatory bowel disease; ulcerative colitis}, abstract = {Data indicate that earlier initiation of anti-tumor necrosis factor alpha (anti-TNF-α) biologic medicines may prevent progression to irreversible bowel damage and improve outcomes for patients with inflammatory bowel disease (IBD), particularly Crohn's disease. However, the high cost of such therapies may restrict access and prevent timely treatment of IBD. Biosimilar anti-TNF-α medicines may represent a valuable opportunity for cost savings and optimized patient outcomes by improving access to advanced therapies and allowing earlier anti-TNF-α treatment initiation. Biosimilar anti-TNF-α medicines have been shown to offer consistent therapeutic outcomes to their reference medicines, yet despite entering the IBD treatment armamentarium over 10 years ago, their implementation in clinical practice remains suboptimal. Factors limiting the 'real' use of biosimilar anti-TNF-α medicines may include an ongoing lack of understanding and acceptance of biosimilars by both healthcare professionals (HCPs) and patients, as well as systemic factors such as formulary decisions outside of the control of the prescriber. In this review, an expert panel of gastroenterologists discusses HCP-level considerations to improve biosimilar anti-TNF-α utilization in IBD in order to support early anti-TNF-α initiation and maximize patient outcomes.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nilssonandreas_2025, title = {Accelerometer-Determined Physical Activity and Sarcopenic Obesity Risk in Older European Men and Women}, author = {Nilsson, Andreas and Limem, Hadil and Santoro, Aurelia and Smeldy Jurado-Medina, Laura and Berendsen, Agnes A. M. and de Groot, Lisette C P G M and Kaluza, Joanna and Sicińska, Ewa and Jennings, Amy and Fairweather-Tait, Susan and Bazzocchi, Alberto and Battista, Giuseppe and Franceschi, Claudio and Driss, Tarak and Kadi, Fawzi}, year = {2025}, journal = {Journal of Cachexia, Sarcopenia and Muscle}, volume = {16}, number = {6}, doi = {10.1002/jcsm.70149}, url = {2023764}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {adiposity; ageing; low intensity physical activity; metabolic risk; moderate‐to‐vigorous physical activity; sarcopenia}, abstract = {BACKGROUND: Sarcopenic obesity (SO) is characterized by the presence of both obesity and sarcopenia and is related to disability and loss of independence in older adults. The extent to which time spent in light physical activity (LPA), or moderate-to-vigorous physical activity (MVPA) is associated with SO risk in older adults remains unclear. The aim of this study was (a) to examine the association between the level of adherence to recommended amounts of MVPA and the risk of SO in older adults and (b) to determine whether time spent in LPA is associated with SO risk independently of time spent in MVPA.METHODS: This cross-sectional study involved 862 community-dwelling older adults (58% women; aged 65-79 years) from four European countries. Accelerometer-determined time in MVPA was categorized as follows: inactive (< 75 min/week), moderately active (75-149 min/week), active (150-299 min/week) and highly active (≥ 300 min/week). Time in LPA was expressed in tertiles. The outcome measure SO risk was determined based on appendicular lean mass, waist circumference, handgrip strength and the 5-times sit-to-stand test. Odds ratios (OR) with a 95% confidence interval (95% CI) of high SO risk across levels of MVPA and LPA were determined by binary logistic regression adjusted for the level of systemic inflammation (high-sensitivity C-reactive protein) and dietary protein intake.RESULTS: Compared to the inactive group, ORs of having a high SO risk were about 50%-80% lower, depending on the MVPA level, with the largest risk reduction in the highly active group (OR: 0.23, 95% CI: 0.13-0.39; p < 0.05). The likelihood of having a high SO risk was significantly lower among the highly active group compared to the active group (OR: 0.50; 95% CI: 0.33-0.77; p < 0.05). More time in LPA was associated with a significantly lower likelihood of having high SO risk (highest vs. lowest tertile: OR: 0.52, 95% CI: 0.30-0.89; p < 0.05) only in participants with low amounts of MVPA. In contrast, LPA was not associated with SO risk among participants meeting the MVPA recommendation.CONCLUSIONS: MVPA is strongly associated with a lower likelihood of having a high SO risk in older adults, independently of the level of systemic inflammation and intakes of dietary proteins. LPA is related to SO risk in sedentary older adults, which supports the promotion of physical activity regardless of intensity for mitigating SO.}, issn = {2190-5991} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_balkmardag_2025, title = {ACCTING Report on Research Line 7 : Cycling Initiatives for an Inclusive Mobility Transition}, author = {Balkmar, Dag and Sandström, Lina}, year = {2025}, doi = {10.5281/zenodo.15525596}, url = {2003775}, language = {eng}, publisher = {Zenodo}, abstract = {This report presents a summary of findings from Research Line 7 of ACCTING’s second cycle of experimental studies, which draws on data gathered from 87 quasi-experimental case studies conducted across thirteen countries between December 2023 and August 2024. Each research line explores sustainability and behavioural change within the framework of a specific European Green Deal policy area—including climate change, biodiversity, energy, food, and transport. This report focuses on transport poverty and sustainable travel, and more specifically on cycling initiatives, examining how policies can support more inclusive and environmentally responsible mobility.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_humphreysabc_2025, title = {ACEi/ARB treatment in patients with myocardial infarction and preserved left ventricular ejection fraction does not confer a benefit : a target trial emulation}, author = {Humphreys, A. B. C. and Lindahl, B. and Berglund, A. and Voelskow, V. and Fang, S. and Fröbert, Ole and Hofmann, R. and Jernberg, T. and Hernan, M. A. and Matthews, A. A.}, year = {2025}, journal = {European Heart Journal}, volume = {46}, number = {Suppl. 1}, doi = {10.1093/eurheartj/ehaf784.1796}, url = {2037875}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background: Angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) are effective in the long-term treatment of individuals with myocardial infarction (MI) and reduced left ventricular ejection fraction. However, there is a lack of randomised trials assessing these agents in those with preserved ejection fraction (≥50%). One approach is to use observational data to emulate a hypothetical pragmatic trial ("target trial") that one would conduct.Methods: We emulated a target trial of ACEis/ARBs versus no ACEis/ARBs in individuals under the age of 75 years with MI and left ventricular ejection fraction ≥50% between September 2010 and June 2021 for the prevention of a composite outcome (death, myocardial infarction, or heart failure) and its individual components. We used the Sweden-wide SWEDEHEART quality registry with linkage to other national registers, enabling complete coverage of hospital care and dispensed drugs. We estimated observational analogues of the intention-to-treat effect and the per-protocol effect with confounding adjustment via inverse probability weighting.Results: The 10,697 individuals in the ACEi/ARB group were on average older (median 61 vs 60 years), more likely to be male (80.2% vs 75.3% male) and more likely to present with STEMI (45.4% vs 27.9%) compared with the 4,730 individuals in the no ACEi/ARB group. In an intention-to-treat analysis, the estimated five-year risk of the composite outcome was 7.8% (95% confidence interval 7.1%, 8.5%) in the ACEi/ARB group and 8.1% (7.0%, 9.3%) in the non-ACEi/ARB group; risk difference -0.3% (-1.6%, 1.0%) (Figure 1). In a per protocol analysis, the risk of the composite outcome was 6.5% (5.9%, 7.2%) in the ACEi/ARB group and 6.7% (5.6%, 8.1%) in the no ACEi/ARB group; risk difference -0.2% (-1.7%, 1.0%) (Figure 2).Conclusions: The estimated risk of a composite of death, myocardial infarction or heart failure was similar in recipients and non-recipients of ACEi/ARB. Our estimates suggest that ACEi/ARB treatment in patients with myocardial infarction and preserved left ventricular ejection fraction does not confer a benefit.}, issn = {0195-668X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nilsagrdylva_2025, title = {Achieving health-promotion practice in primary care using a multifaceted implementation strategy : a non-randomized parallel group study}, author = {Nilsagård, Ylva and Smith, Daniel Robert and Söderqvist, Fredrik and Nilsing Strid, Emma and Wallin, Lars}, year = {2025}, journal = {Implementation Science Communications}, volume = {6}, number = {1}, doi = {10.1186/s43058-025-00723-y}, url = {1950755}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {change management; clinical practice guidelines; health promotion; healthy lifestyle; implementation science; primary health care}, abstract = {BACKGROUND: Evidence-based healthcare recommendations exist for tobacco use, harmful alcohol consumption, low physical activity, and poor diet. However, the uptake of these recommendations in Swedish primary healthcare is poor, and the potential benefits for patients are not fully realized. Our aim was to evaluate the effect (i.e. the uptake) of a 12-month multifaceted implementation strategy to achieve a more health-promoting practice. We hypothesized that primary healthcare centers receiving this strategy would increase and sustain their health-promotion practices to a significantly greater extent than control centers, from baseline to the 6-month follow-up.METHODS: In a non-randomized parallel group study, 5 intervention centers and 5 matched control centers were compared regarding health-promotion activities delivered in relation to visits to each center. The intervention centers received a multifaceted implementation strategy over at least 12 months based on established strategies, the Astrakan model of leading change, and findings from pre-implementation studies. The main strategies were: using external and internal facilitators to combine bottom-up and top-down perspectives, and emphasizing leadership responsibility for change. Medical record data on health-promotion activities, including prescribed physical activity and use of lifestyle screening forms, were collected monthly for 2 years: 6 months before and after implementation, and during the implementation phase. The implementation strategy effect was estimated using generalized linear mixed models.RESULTS: During the 12-month implementation phase, the intervention and control sites had 135 002 and 160 987 healthcare visits, respectively; conducted 8839 and 6171 health-promotion activities, respectively; and administered 2423 and 282 lifestyle screening forms, respectively. A statistically significant higher relative uptake rate of health-promotion activities was found in intervention sites compared to control sites after the implementation period compared to before. The effect increased during the active phase, with the intervention sites having on average 1.07 and 2.0 times the uptake rate of the control sites at 1 and 12 months, respectively; this effect was largely maintained during the 6-month post-intervention phase. A significant absolute effect, in terms of difference in predicted uptake per 1000 visits, was evident 7 months into the implementation phase.CONCLUSION: This multi-faceted implementation strategy was successful in achieving a more health-promoting practice.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisioannis_2025, title = {ACHIEVING REMISSION AND LOW DISEASE ACTIVITY WITH BELIMUMAB VERSUS PLACEBO IN PATIENTS WITH SLE EXCLUDING THE GLUCOCORTICOID COMPONENT FROM TARGET DEFINITIONS : A POST HOC ANALYSIS OF FIVE PHASE 3 TRIALS}, author = {Parodis, Ioannis and Lindblom, J. and Levy, R. A. and Tsoi, A. and Zen, M. and Nikopoulos, D. and Khamashta, M. and Tomlinson, R. and Askanase, A. and van Vollenhoven, R. and Nikpour, M.}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {84}, number = {Suppl. 1}, pages = {927--929}, doi = {10.1016/j.ard.2025.06.127}, url = {1986306}, language = {eng}, publisher = {Elsevier}, keywords = {outcome measures; biological dmard; randomised controlled trial; remission}, abstract = {Background: Belimumab (BEL) is a human IgG1λ monoclonal antibody that selectively binds to soluble BLyS and is approved for systemic lupus erythematosus (SLE) and lupus nephritis. In an integrated post hoc analysis of five Phase 3 trials (publications ranging years 2011–2022) in adults with active SLE, BEL plus standard therapy (ST) showed greater benefit than placebo (PBO) plus ST in attaining Definition of Remission in SLE (DORIS) remission (8% vs 6%) and Lupus Low Disease Activity State (LLDAS; 17% vs 10%) at Week 52. The DORIS remission and LLDAS definitions include SLE Disease Activity Index 2000 (SLEDAI-2K), Physician's Global Assessment (PGA) and glucocorticoid (GC) dose components. As the five included trials were conducted before GC tapering recommendations were introduced, GC tapering was not mandated, resulting in prolonged GC courses in a substantial proportion of patients, with a major impact on the attainability of DORIS remission and LLDAS in these trials.Objectives: To assess attainment of DORIS remission and LLDAS with BEL versus PBO based on DORIS and LLDAS definitions excluding the GC requirement (non-GC-DORIS and non-GC-LLDAS), in the pooled population of five Phase 3 trials.Methods: This post hoc analysis pooled data for adults with active, seropositive SLE (antinuclear antibodies and/or anti-dsDNA antibodies) from five trials (BLISS-76 [GSK Study 110751, NCT00410384], BLISS-52 [GSK Study 110752, NCT00424476], North East Asia [GSK Study 113750, NCT01345253], BLISS-SC [GSK Study 112341, NCT01484496] and EMBRACE [GSK Study 115471, NCT01632241]), receiving BEL (10 mg/kg/month intravenous or 200 mg/week subcutaneous) or PBO, plus ST. Non-GC-DORIS remission and non-GC-LLDAS attainment rates were calculated based on SLEDAI-2K and PGA scores, allowing for GC doses above the DORIS and LLDAS criteria thresholds (see Figure 1 for full definitions). Proportions of attainers were calculated and comparisons between BEL and PBO were conducted every 4 weeks to Week 52, using modified Poisson regression adjusted for trial variance, in all patients and in subgroups based on the following baseline/patient characteristics: SLEDAI-2K score, anti-dsDNA positivity, complement levels, GC dose, antimalarial use, and patient race.Results: Data for 1869 BEL and 1217 PBO patients were analysed. At Week 52, non-GC-DORIS remission and non-GC-LLDAS attainment were higher with BEL versus PBO (non-GC-DORIS remission: 18.0% vs 12.8%, risk ratio, RR [95% confidence interval, CI]: 1.44 [1.20, 1.71], p<0.001; non-GC-LLDAS: 32.2% vs 21.4%, RR [95% CI]: 1.50 [1.32, 1.71], p<0.001). Statistical significance that was maintained to Week 52 was reached by Weeks 20 and 24 for non-GC-DORIS remission and non-GC-LLDAS, respectively (Figure 1). At Week 52, significantly greater proportions of patients treated with BEL versus PBO were in non-GC-DORIS remission and non-GC-LLDAS across most patient subgroups defined by baseline characteristics (Figure 2). In patients with a baseline SLEDAI-2K score ≥10, significantly greater proportions achieved maintained non-GC-DORIS remission and non-GC-LLDAS with BEL versus PBO as early as Week 16 (non-GC-DORIS remission: RR [95% CI]: 1.95 [1.20, 3.16], p=0.009; non-GC-LLDAS: RR [95% CI]: 1.54 [1.17, 2.02], p=0.003). At Week 52, the proportions of non-GC-DORIS remission and non-GC-LLDAS attainment were higher with BEL versus PBO for Asian (BEL n=698, PBO n=405; non-GC-DORIS remission: 14.6% vs 9.6%, RR [95% CI]: 1.60 [1.13, 2.27], p=0.013; non-GC-LLDAS: 28.9% vs 18.0%, RR [95% CI]: 1.59 [1.25, 2.02], p=0.001) and White patients (BEL n=596, PBO n=436; non-GC-DORIS remission: 20.6% vs 12.2%, RR [95% CI]: 1.66 [1.23, 2.25], p=0.002; non-GC-LLDAS: 35.9% vs 20.2%, RR [95% CI] 1.76 [1.42, 2.19], p<0.001), but a numerical difference only was seen for patients of Black African ancestry (BEL n=403, PBO n=229; non-GC-DORIS remission: 15.6% vs 13.5%, RR [95% CI]: 1.13 [0.76, 1.69], p=0.577; non-GC-LLDAS: 27.3% vs 23.6%, RR [95% CI]: 1.14 [0.86, 1.51]; p=0.438) or Indigenous American patients (BEL n=172, PBO n=147; non-GC-DORIS remission: 27.9% vs 22.4%, RR [95% CI]: 1.17 [0.80, 1.71], p=0.496; non-GC-LLDAS: 43.6% vs 30.6%, RR [95% CI]: 1.35 [1.00, 1.82], p=0.117).Conclusion: When analysing data from past trials, it is key to consider their context and timing, and the effect of confounding factors, an example being current guidelines for GC. Importantly, GC taper was not mandated in the BEL trial protocols and it was not a part of the assessment of BEL benefit. In this post hoc analysis of five Phase 3 BEL trials using DORIS remission and LLDAS criteria excluding the GC component, BEL plus ST was associated with higher attainment of both outcomes compared with PBO plus ST in the overall population and across most analysed patient subgroups. Attainment rates with the exclusion of the GC component from the DORIS and LLDAS criteria were ~2-fold higher than those previously reported with the full definitions. This analysis corroborates the benefit of BEL plus ST over PBO plus ST in inducing remission and low disease activity in patients with SLE.}, issn = {0003-4967} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_anderssonannika_2025, title = {Activism of the oppressed : a  literature study on digital activism in undemocratic countries}, author = {Andersson, Annika and Hatakka, Mathias and Hedström, Karin and Larsson, Hannu}, year = {2025}, url = {2026417}, language = {eng}, keywords = {digital activism; undemocratic countries; ict4d; literature study; social movement}, abstract = {In a world marked by democratic decline, the aim of this paper is to summarize research on digital activism in undemocratic countries. We examine how the field of ICT4D can engage with digital activism research in such contexts by highlighting both the role of technology in enabling activism and the profiles of those conducting this research. Based on a scoping review, we find that the main enabler of technology use in undemocratic countries is its capacity to support on-the-ground organizing and to sustain network of activists together in a community. The major constraint, however, is government surveillance and censorship. We conclude by arguing that future studies should involve activists in both conducting and reflecting on the research, in order to generate meaningful and practice-oriented insights. Inspiration can be drawn from action-oriented and practitioner-focused methodologies, including—but not limited to—those used in information systems. Furthermore, future research should explore technological challenges in greater depth, particularly issues related to security and anonymity. Addressing these challenges requires the involvement of information systems researchers with expertise in security and privacy.}, file = {https://oru.diva-portal.org/smash/get/diva2:2026417/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lfelin_2025, title = {Acupuncture for the treatment of infantile colic}, author = {Lööf, Elin and H. Skogman, Barbro and Cabano, Rita and Sylvan, Robin and Bruschettini, Matteo}, year = {2025}, journal = {Cochrane Database of Systematic Reviews}, volume = {10}, doi = {10.1002/14651858.CD016305}, url = {2005457}, language = {eng}, publisher = {John Wiley & Sons}, abstract = {This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of acupuncture for the treatment of infantile colic.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sundhjosefin_2025, title = {Acute cardiovascular events following a severe COPD exacerbation - incidence, association with treatments, and impact of the COVID-19 viral pandemic}, author = {Sundh, Josefin and Janson, Christer and Ellingsen, Jens and Malinovschi, Andrei and Wettermark, Bjorn and Dahlén, Elin and Kirui, Brian and Li, Huiqi and Nyberg, Fredrik}, year = {2025}, journal = {European Respiratory Journal}, volume = {66}, number = {Suppl. 69}, doi = {10.1183/13993003.congress-2025.PA3681}, url = {2039646}, language = {eng}, publisher = {European Respiratory Society}, issn = {0903-1936} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_scharfmathiasw_2025, title = {Acute effects of butyrate on intestinal permeability in patients with irritable bowel syndrome assessed by a novel colonoscopy research model}, author = {Scharf, Mathias W. and Forsgård, Richard A. and Prado, Samira B. R. and Ganda Mall, John Peter and Repsilber, Dirk and Brummer, Robert J. and Marques, Tatiana M. and Wall, Rebecca}, year = {2025}, journal = {Gut microbes}, volume = {17}, number = {1}, doi = {10.1080/19490976.2025.2545414}, url = {1991636}, language = {eng}, publisher = {Taylor & Francis}, keywords = {ibs; intestinal barrier function; in vivo; ussing chamber}, abstract = {Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder for which effective treatment strategies are insufficient. Butyrate, a microbiota-derived short-chain fatty acid believed to strengthen the intestinal barrier function, might be a potential new treatment option. This study aimed to investigate potential protective effects of acute in vivo butyrate exposure on intestinal barrier function in healthy subjects and patients with IBS. For this, we used an experimental colonoscopy-perfusion model for colon-specific butyrate delivery and adequate tissue sampling. Seventeen IBS and 17healthy subjects underwent a colonoscopy procedure exposing a predefined colonic area to 100mmol/L butyrate for 90 min in vivo. Mucosal biopsies collected pre- and post-butyrate exposure were stimulated in Ussing chambers with/without sodium deoxycholate (DC) to induce intestinal hyperpermeability. Intestinal permeability was measured by fluorescein isothiocyanate-dextran and horseradish peroxidase passage. DC-stimulation significantly increased para- and transcellular permeability in biopsies collected pre-butyrate exposure. DC-induced transcellular hyperpermeability was significantly alleviated in biopsies collected post-butyrate exposure compared to pre-exposure in patients with IBS (p = 0.034). In conclusion, we established a colonoscopy research model for colon-specific delivery and sampling and demonstrated acute protective effects of butyrate on transcellular intestinal permeability in patients with IBS. The results support butyrate's potential role in novel treatment strategies in IBS. Clinicaltrials.gov number: NCT05249023.}, issn = {1949-0976} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_honapsailish_2025, title = {Acute Severe Ulcerative Colitis : An International Delphi Consensus on Clinical Trial Design and Endpoints}, author = {Honap, Sailish and Jairath, Vipul and Sands, Bruce E. and Dulai, Parambir S. and Higgins, Peter Dr and De Cruz, Peter and Gutiérrez, Ana and Kotze, Paulo G. and Ye, Byong Duk and Kobayashi, Taku and Gearry, Richard B. and Olivera, Pablo A. and Amiot, Aurélien and Mosli, Mahmoud H. and Al Awadhi, Sameer and Halfvarson, Jonas and Patel, Kamal V. and Sebastian, Shaji and Danese, Silvio and Peyrin-Biroulet, Laurent}, year = {2025}, journal = {Clinical Gastroenterology and Hepatology}, volume = {23}, number = {8}, doi = {10.1016/j.cgh.2024.10.029}, url = {1922308}, language = {eng}, publisher = {Elsevier}, keywords = {ulcerative colitis; acute severe ulcerative colitis; randomized controlled clinical trial; trial design}, abstract = {BACKGROUND & AIMS: Interventional clinical trials in ASUC are characterised by substantial heterogeneity due to a lack of consensus in several key areas of trial design - this impedes clinical research efforts to identify novel therapies. The objective of this initiative was to achieve the first consensus and provide clear position statements on ASUC trial design.METHODS: A modified Delphi consensus approach was employed with a panel of twenty clinicians with international representation and expertise in ASUC trial design and delivery. Agreement was defined as at least 75% of participants voting as 'agree' with each statement.RESULTS: In total, thirty statements achieved consensus and were approved. Statements centred on proposing suitable eligibility criteria (disease extent, disease severity, prior therapy exposure), optimising trial design (randomisation, stratification, corticosteroid handling, timing of assessments), and recommending primary and secondary endpoints alongside defining key efficacy outcomes (clinical and endoscopic reponse and remission, treatment failure, quality of life).CONCLUSIONS: The expansion of drugs to treat moderate-severe UC over the past decade, particularly the rapidly acting Janus kinase inhibitors, is promising and has reignited the interest in identifying suitable therapeutic candidates for ASUC. Clinical trials in this high-risk population are challenging to conduct and this consensus provides a framework for future trials to advance drug development.}, issn = {1542-3565} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sannerjohan_2025, title = {Acute stroke in persons 85 years or older-clinical characteristics, impact of frailty, and predictors of outcome}, author = {Sanner, Johan and Thommessen, Bente and von Euler, Mia and Ström, Jakob O. and Fure, Brynjar}, year = {2025}, journal = {Frontiers in Neurology}, volume = {16}, doi = {10.3389/fneur.2025.1689225}, url = {2016160}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {frailty; older; outcome; predictors; stroke}, abstract = {INTRODUCTION: Stroke cases among older people will increase due to demographic changes, necessitating an optimization of care strategies for this population. We aimed to examine clinical characteristics, prognostic factors, and the impact of frailty in an older stroke cohort.PATIENTS AND METHODS: We consecutively included 120 patients aged ≥85 years with acute ischemic or hemorrhagic stroke at a regional hospital in Sweden. Baseline characteristics, etiological subclassification, National Institutes of Health Stroke Scale (NIHSS) on admission, pre- and post-stroke functional level and frailty, measured by the modified Rankin Scale (mRS), the Barthel ADL Index (BI), and the Clinical Frailty Scale (CFS), were recorded. Regression analyses were conducted to evaluate predictors of death or poor functional outcome, defined as an mRS of ≥4, at 3 months. RESULTS: The mean age was 89.1 years and 57.5% were women. Ischemic strokes accounted for 90.8% and atrial fibrillation was diagnosed in 55.8%. Overall, 26.6% received reperfusion therapy. At 3 months, the mortality and poor functional outcomes were 35.8 and 54.2%, respectively. A multivariate regression analysis identified age ≥89 years, BI ≤70, CFS ≥ 7 prior to stroke, total anterior circulation infarction, NIHSS ≥15 on admission, and post-stroke dysphagia as independent predictors of death or poor outcome.DISCUSSION AND CONCLUSION: We found a high prevalence of cardioembolic disease in older people with stroke, emphasizing the importance of diagnosing atrial fibrillation and optimizing anticoagulant treatment. In addition to well-known predictors, severe frailty prior to stroke and post-stroke dysphagia predicted poor outcome. In the growing older stroke population, assessment of frailty may be beneficial in decision-making regarding interventions and direction of care.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kofodl_2025, title = {Adaptive Oxygen Delivery in Home Settings for Patients With Chronic Obstructive Pulmonary Disease on Long-Term Oxygen Therapy - A Pilot Randomized Crossover Feasibility Trial}, author = {Kofod, L. and Hansen, E. F. and Kristensen, M. T. and Brocki, B. C. and Westerdahl, Elisabeth}, year = {2025}, journal = {American Journal of Respiratory and Critical Care Medicine}, volume = {211}, number = {Suppl.}, doi = {10.1164/ajrccm.2025.211.Abstracts.A1046}, url = {1962962}, language = {eng}, publisher = {HighWire Press}, abstract = {Rationale: In patients with COPD on long-term oxygen therapy (LTOT), oxygen doses are typically set at rest to maintain saturation above 90% while avoiding hyperoxemia, despite fluctuating needs throughout the day. Although emerging technology enables continuous, saturation-based adjustments, it is unclear whether such adjustments are feasible in a home setting. This pilot study assessed the feasibility and preliminary effect of saturation-responsive automated oxygen adjustments at home.Methods: The intervention consisted of four days of continuous oxygen titration using an electronic device. Patients wore a wrist pulse oximeter that connected to the device via Bluetooth, creating a closed-loop system. In this setup, oxygen flow was adjusted from 1- 7 L/min based on real-time oxygen saturation (SpO₂), targeting a level of 90% to 94%. In the control period, the patients received their usual fixed oxygen, and they were not blinded to the intervention. Data were transmitted to a cloud-based solution. Feasibility was defined as successful time during which the patients were automatically titrated, patients´ willingness toward the intervention, and clinically relevance. The Clinical COPD Questionnaire (CCQ, 0-6 points, with 0.4 suggested as a minimal important difference) evaluated changes in the 24-hour health status.Results: Twelve patients, four women and eight men with an average ±SD home oxygen dose of 2.0 ± 0.8 L/min were included. The patients' oxygen flow was automatically adjusted for a median (interquartile range) of 77 (68.0-84.3) hours per patient, reflecting 83% of the time they were compliant with wearing the equipment. More than 217,000 paired live data points on SpO2 and oxygen flow were received on average per patient. The time spent within target was statistically different between arms with 51.3 ± 12.2% when using fixed oxygen flow, and 83.4 ± 8.3% of the time when flow was automatically adjusted, p<0.001. Complaints from the patients were mainly regarding the noise from the 9 L oxygen concentrator. A change in the CCQ score of 0.74 ± 0.47 points favored the automated oxygen titration, p<0.001.Conclusion: It is possible to titrate oxygen flow in a home setting and achieve almost perfect control of SpO2, minimizing time with hypoxemia. The patients in this pilot study accepted the equipment and reported a statistical and clinically significant reduction in COPD symptoms measured with CCQ. The clinical importance of controlling SpO2 needs to be examined in a larger study.}, issn = {1073-449X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sigmundssonfreyrgauti_2025, title = {Additional Operations Following Sacroiliac Joint Fusions : A Minimum 3-year Follow-up Cohort Study of Patients Operated for Chronic Sacroiliac Joint Pain}, author = {Sigmundsson, Freyr Gauti and Randers, Engelke Marie and Kibsgård, Thomas and Gerdhem, Paul and Joelson, Anders}, year = {2025}, journal = {Clinical spine surgery}, volume = {38}, number = {10}, pages = {E535--E540}, doi = {10.1097/BSD.0000000000001791}, url = {1944275}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, keywords = {sacroiliac joint fusion; sacroiliac joint pain; sacroiliac joint dysfunction; outcome}, abstract = {STUDY DESIGN: A retrospective analysis of prospectively collected registry data.OBJECTIVE: To examine the subsequent pattern of surgeries and outcome of sacroiliac joint fusions (SJF) in patients previously operated in the lumbar spine as well as those scheduled for primary SJF.SUMMARY OF BACKGROUND DATA: Patients with SI joint pain often have a history of previous back surgery, but it is unclear how often patients require back surgery after SI-joint fusion.METHODS: We obtained data from the national Swedish spine registry on all patients who underwent a SJF between 1998 and 2019 and identified previous and additional operations of any type after a SJF between 1998 and 2022. The EuroQol EQ VAS and the Oswestry disability index (ODI) were registered preoperatively and 1 year after the last undergone surgery. Satisfaction with treatment was assessed 1 year after surgery.RESULTS: Two hundred seventy-nine patients underwent SJF between 1998 and 2019. Ninety-five of 279 patients (34%) underwent primary SJF, and 184 of 279 patients (66%) underwent SJF after spine surgery. Forty-one of 95 patients (43%) underwent additional spine or SI-joint surgery after a primary SJF. The most common additional procedure was contralateral SJF (22 of 41; 54%). The mean EQ-VAS change after primary SJF was 19 points (95% CI 12-26), whereas the corresponding value for SJF after previous lumbar spine surgery was 9 points (95% CI 2-16). The corresponding values for the mean ODI change were -14 points (95% CI -19 to -10) and -9 points (95% CI -14 to -4) respectively. Seventy-three percent (37 of 51) and 54% (34 of 63) were satisfied after SJF after primary versus secondary SJF.CONCLUSION: After primary SJF most additional surgeries are for contralateral symptoms and 9% required lumbar surgery after their SJF. Two-thirds of the patients with SJF have had their surgery after lumbar surgery.}, issn = {2380-0186} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_kremelanna_2025, title = {Addressing the Integration of Key Competencies for Sustainability : A Case Study of Design Thinking in Entrepreneurship Education in Sweden}, author = {Kremel, Anna and Dyrvik, Mattias}, year = {2025}, pages = {87--101}, doi = {10.1007/978-3-031-77513-0_5}, url = {1946181}, language = {eng}, publisher = {Springer}, abstract = {For the transition to a sustainable society, it has been argued that higher education should provide students with competencies other than strictly subject-specific, such as key competencies for sustainability. This chapter discusses how key competencies were implemented in an entrepreneurship course in a business school in Sweden. In the course, design thinking was used as a method. During the process, the students solved real-world social challenges related to sustainability and Agenda 2030 SDGs. Students analyzed complex societal challenges from an interdisciplinary and needs-based perspective while learning sustainable key competencies: systems thinking, future thinking, values thinking, strategic thinking, and collaboration. Results show that key competencies for sustainability can be taught through entrepreneurship and that some key competencies were more advanced than others. This knowledge can be used to further develop the curriculum to implement key competencies for sustainability.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zhangle_2025, title = {ADHD drug treatment and risk of suicidal behaviours, substance misuse, accidental injuries, transport accidents, and criminality : emulation of target trials}, author = {Zhang, Le and Zhu, Nanbo and Sjölander, Arvid and Nourredine, Mikail and Li, Lin and Garcia-Argibay, Miguel and Kuja-Halkola, Ralf and Brikell, Isabell and Lichtenstein, Paul and D'Onofrio, Brian M and Larsson, Henrik and Cortese, Samuele and Chang, Zheng}, year = {2025}, journal = {The BMJ}, volume = {390}, doi = {10.1136/bmj-2024-083658}, url = {1990102}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, abstract = {OBJECTIVE: To examine the effects of drug treatment for attention deficit/hyperactivity disorder (ADHD) on suicidal behaviours, substance misuse, accidental injuries, transport accidents, and criminality.DESIGN: Emulation of target trials.SETTING: Linkage of national registers in Sweden, 2007-20.PARTICIPANTS: People aged 6-64 years with a new diagnosis of ADHD, who either started or did not start drug treatment for ADHD within three months of diagnosis.MAIN OUTCOME MEASURES: First and recurrent events of five outcomes over two years after ADHD diagnosis: suicidal behaviours, substance misuse, accidental injuries, transport accidents, and criminality.RESULTS: Of 148581 individuals with ADHD (median age 17.4 years; 41.3% female), 84282 (56.7%) started drug treatment for ADHD, with methylphenidate being the most commonly prescribed at initiation (74515; 88.4%). Drug treatment for ADHD was associated with reduced rates of the first occurrence of suicidal behaviours (weighted incidence rates 14.5 per 1000 person years in the initiation group versus 16.9 in the non-initiation group; adjusted incidence rate ratio 0.83, 95% confidence interval 0.78 to 0.88), substance misuse (58.7 v 69.1 per 1000 person years; 0.85, 0.83 to 0.87), transport accidents (24.0 v 27.5 per 1000 person years; 0.88, 0.82 to 0.94), and criminality (65.1 v 76.1 per 1000 person years; 0.87, 0.83 to 0.90), whereas the reduction was not statistically significant for accidental injuries (88.5 v 90.1 per 1000 person years; incidence rate ratio 0.98, 0.96 to 1.01). The reduced rates were more pronounced among individuals with previous events, with incidence rate ratios ranging from 0.79 (0.72 to 0.86) for suicidal behaviours to 0.97 (0.93 to 1.00) for accidental injuries. For recurrent events, drug treatment for ADHD was significantly associated with reduced rates of all five outcomes, with incidence rate ratios of 0.85 (0.77 to 0.93) for suicidal behaviours, 0.75 (0.72 to 0.78) for substance misuse, 0.96 (0.92 to 0.99) for accidental injuries, 0.84 (0.76 to 0.91) for transport accidents, and 0.75 (0.71 to 0.79) for criminality.CONCLUSIONS: Drug treatment for ADHD was associated with beneficial effects in reducing the risks of suicidal behaviours, substance misuse, transport accidents, and criminality but not accidental injuries when considering first event rate. The risk reductions were more pronounced for recurrent events, with reduced rates for all five outcomes. This target trial emulation study using national register data provides evidence that is representative of patients in routine clinical settings.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nordenskjldannam_2025, title = {Adherence to secondary preventive treatment following myocardial infarction with and without obstructive coronary artery disease}, author = {Nordenskjöld, Anna M. and Qvarnström, Miriam and Wettermark, Björn and Lindahl, Bertil}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {5}, doi = {10.1371/journal.pone.0324072}, url = {1965695}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {Background: Secondary preventive medications following myocardial infarction (MI) reduce the risk of new cardiovascular events. Discontinuation and suboptimal adherence are common and affect prognosis. However, there is limited knowledge regarding adherence in patients with myocardial infarction with non-obstructive coronary arteries (MINOCA). We therefore aim to evaluate the adherence to guideline recommended medications in patients with MINOCA and myocardial infarction with obstructive coronary arteries (MI-CAD).Methods: This was a Swedish nationwide observational study of MI patients recorded in the SWEDEHEART registry between 2006 & horbar;2017. A total of 9,138 MINOCA and 107,240 MI-CAD patients were followed for a mean 5.9 years. Initiation of therapy, implementation determined using medication possession ratio, and persistence rates during different time periods were calculated.Results: Patients with MINOCA were less frequently prescribed secondary preventive medications than MI-CAD. The percentage of patients taking medication as prescribed were lower in MINOCA than in MI-CAD at all time points; during months 6-12 after discharge: aspirin 94.8% vs 97.2% (p < 0.001), statins 90.3% vs 94.7% (p < 0.001), and ACEI/ARBs 97.7% vs 98.5% (p = 0.002) and at 12 months: aspirin 84.4% vs 93.7% (p < 0.001), statins 83.8% vs 94.8% (p < 0.001), ACEI/ARBs 85.0% vs 92.2% (p < 0.001) and beta blockers 80.4% vs 89.6% (p < 0.001).Conclusion: The rates of initiation, implementation, and persistence of secondary preventive medications were high in both MINOCA and MI-CAD patients during the first 5 years after MI. The lower rates in patients with MINOCA may be partially due to uncertainties regarding the diagnosis of MINOCA, differences in patient characteristics, and psychosocial factors. Suboptimal medical adherence in patients with MINOCA may adversely affect prognosis as previously demonstrated in MI-CAD patients.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_papakonstantinouandri_2025, title = {Adjuvant endocrine treatment strategies for non-metastatic breast cancer : a network meta-analysis}, author = {Papakonstantinou, Andri and Villacampa, Guillermo and Navarro, Victor and Oliveira, Mafalda and Valachis, Antonis and Pascual, Tomas and Matikas, Alexios}, year = {2025}, journal = {eClinicalMedicine}, volume = {81}, doi = {10.1016/j.eclinm.2025.103116}, url = {1942766}, language = {eng}, publisher = {Elsevier}, keywords = {aromatase inhibitor; breast cancer; endocrine treatment; estrogen receptor; tamoxifen}, abstract = {BACKGROUND: Multiple trials have evaluated escalation strategies of endocrine therapy for early breast cancer, including ovarian function suppression (OFS) and aromatase inhibitors (AI) in premenopausal patients and extended endocrine therapy. However, several aspects remain controversial due to the heterogeneity of study designs and lack of statistical power in relevant subgroups. We aimed to investigate the optimal endocrine therapy strategy.METHODS: A systematic literature search was performed and last updated in August 2024 to identify randomized controlled trials (RCT) evaluating endocrine treatment strategies for hormone receptor positive breast cancer. A network meta-analysis with a frequentist framework using random-effects model was used to pool direct and indirect evidence. In addition, an extracted individual patient data meta-analysis was conducted to estimate the absolute differences between treatments. Study endpoints were disease-free survival (DFS), overall survival (OS), and safety. PROSPERO: CRD42023447979.FINDINGS: A total of 37 RCT that had enrolled 107,684 patients were included in the study. During the first five years, OFS + AI was the most effective strategy in premenopausal women, while AI or switch strategy showed the better efficacy results in postmenopausal ones. Following five years of tamoxifen, continuation with five additional years of AI was associated with improved 8-year DFS (85.8%) compared to no extended therapy (78.1%) or five additional years of tamoxifen (81.0%). Following five years of AI or switch strategy, extended treatment with AI improved DFS (Hazard Ratio = 0.81, 95% Confidence Interval 0.73-0.90).INTERPRETATION: This study provides information regarding the optimal endocrine treatment strategies for patients with resected hormone receptor positive early breast cancer. FUNDING: None.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hgglundmaria_2025, title = {Adult Proxy Online Record Access - Differences Across Four Countries}, author = {Hägglund, Maria and Scott Duncan, Therese and Hagström, Josefin and Kujala, Sari and Dudkina, Anna and Moll, Jonas and Kharko, Anna and Johansen, Monika A. and Blease, Charlotte}, year = {2025}, journal = {Studies in Health Technology and Informatics}, volume = {332}, pages = {216--220}, doi = {10.3233/SHTI251530}, url = {2003830}, language = {eng}, publisher = {IOS Press}, keywords = {electronic health record; information sharing; patient portal; patients’ online record access; proxy access}, abstract = {Patients' online record access (ORA) enables patients to involve their informal caregivers in care management by sharing health information, either through proxy access functionality or informally. The European Health Data Space mandates that member countries should ensure that patients can assign a proxy to have online access to their health data. In this study, we aimed to explore the current state of proxy ORA in four countries with mature ORA implementations; Sweden, Norway, Finland, and Estonia. We identified three types of proxy ORA; full proxy ORA, no proxy ORA, and controlled proxy ORA. Further guidance on ethically sound and secure proxy ORA functionality that complies with national and EU regulations and policies is warranted to ensure equal rights for citizens across Europe.}, issn = {0926-9630} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_brmsgabriella_2025, title = {Adult-onset inflammatory bowel disease and the risk of venous thromboembolism : a Swedish nationwide cohort study 2007-2021}, author = {Bröms, Gabriella and Forss, Anders and Eriksson, Julia and Askling, Johan and Eriksson, Carl and Halfvarson, Jonas and Linder, Marie and Sun, Jiangwei and Westerlund, Eli and Ludvigsson, Jonas F. and Olén, Ola}, year = {2025}, journal = {Scandinavian Journal of Gastroenterology}, volume = {60}, number = {6}, pages = {526--535}, doi = {10.1080/00365521.2025.2488053}, url = {1954810}, language = {eng}, publisher = {Taylor & Francis}, keywords = {crohn’s disease; inflammatory bowel disease; ulcerative colitis; venous thromboembolism}, abstract = {BACKGROUND: Earlier studies, mainly prior to the widespread use of advanced therapy and implementation of guidelines for thromboprophylaxis indicate a doubled risk of venous thromboembolism (VTE) in patients with inflammatory bowel disease (IBD).METHODS: Using Swedish healthcare registers, we identified a population-based cohort of patients with incident IBD 2007-2021. Patients were matched by age, sex, calendar year of birth and place of residence with up to 10 reference individuals. The primary outcome was VTE, i.e., pulmonary embolism (PE) and deep vein thrombosis (DVT). Incidence rates (IRs) per 1000 person-years, cumulative incidence and hazard ratios (HRs) were calculated for IBD overall and according to clinical characteristics. The temporal trend of the incidence of VTE by calendar year was presented.RESULTS: We followed 55,252 IBD patients and 536,067 reference individuals, for a median of 6.5 years. The incidence of VTE in IBD was 5.03 vs. 2.35 per 1000 person-years among reference individuals, corresponding to a doubled risk of VTE (HR = 2.12; 95% confidence interval [CI] 2.02-2.23). Particularly high risks were seen in the first year of follow-up, and among patients with extensive ulcerative colitis (UC), primary sclerosing cholangitis (PSC), extraintestinal manifestations, perianal disease and hospitalization at diagnosis. The occurrence of VTE in IBD did not decrease across calendar years.CONCLUSIONS: IBD remains linked to an elevated risk of VTE, particularly with disease characteristics associated with a higher inflammatory burden and higher age. Our findings underscore the importance of continuous vigilance and individual assessment of VTE risk in patients with IBD.}, issn = {0036-5521} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_leblanckimberly_2025, title = {Adults living with dementia and chronic wounds, wound types, care challenges, and impact across dementia stages : A scoping review protocol}, author = {LeBlanc, Kimberly and Woo, Kevin and Gethin, Georgina and Beeckman, Dimitri and Heerschap, Corey and Reddy, Madhuri and Parker, Christina and MacAndrew, Margaret and White-Chu, Foy and Wiesenfeld, Samantha}, year = {2025}, journal = {Journal of tissue viability}, volume = {34}, number = {1}, doi = {10.1016/j.jtv.2024.12.009}, url = {1925695}, language = {eng}, publisher = {Elsevier}, keywords = {chronic wounds; dementia; elderly care; skin integrity; wound care challenges}, abstract = {OBJECTIVE: The objective of this scoping review is to map the existing evidence on the epidemiology, care challenges, and impacts of various wound types among individuals living with dementia across different stages of the disease. INTRODUCTION: Dementia is a growing global health concern, projected to rise significantly as the population ages. This condition not only affects cognitive function but also increases the risk of chronic wounds in part due to impairments in mobility, self-care, and communication. Current wound care guidelines inadequately address the specific needs of individuals with dementia. This scoping review seeks to fill this gap by comprehensively exploring the intersection between dementia and wound care.INCLUSION CRITERIA: This review will include studies involving adults aged 18 and older diagnosed with dementia or cognitive impairment who are experiencing alterations in skin integrity, such as pressure injuries, venous and arterial ulcers, and diabetic ulcers. Both qualitative and quantitative studies will be considered, as well as studies focusing on the challenges faced by caregivers in managing wounds in this population. Excluded are studies such as editorials and opinion articles.METHODS: A comprehensive search strategy will be employed across multiple electronic databases, including MEDLINE, CINAHL, PsycINFO, EMBASE, and PubMed, as well as grey literature sources like ProQuest Dissertations & Theses Global and OpenGrey. The search will include studies published in English and French without date restrictions. Data will be extracted using a pilot-tested tool and presented in graphical, diagrammatic, and tabular formats. A narrative summary will accompany these visuals, providing context and insights into the data in relation to the review's objectives.}, issn = {0965-206X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_popiolekmarcin_2025, title = {Advancing decision-making in shock wave lithotripsy for upper ureteral stones : the role of radiological stone impaction markers}, author = {Popiolek, Marcin and Jendeberg, Johan and Olin, Max and Wagenius, Magnus and Sundqvist, Pernilla and Lidén, Mats}, year = {2025}, journal = {Urolithiasis}, volume = {53}, number = {1}, doi = {10.1007/s00240-025-01797-y}, url = {1986552}, language = {eng}, publisher = {Springer}, keywords = {shock wave lithotripsy; ureteral stone; inflammation; impaction markes}, abstract = {This work aims to evaluate whether radiological signs of stone impaction (RSSI) measured on non-contrast computed tomography (CT) can predict shock wave lithotripsy (SWL) outcomes for upper ureteral stones and to assess whether integrating these markers into an existing prediction model (the Niwa nomogram) improves predictive performance. We retrospectively analysed 256 patients treated with SWL for upper ureteral stones between 2012 and 2019. Standard stone parameters and RSSI, including ureteral wall thickness (UWT), ureteral diameters and CT attenuations above and below the stone, were assessed. Multivariable logistic regression, receiver operating characteristic (ROC) analysis, net reclassification improvement (NRI) and decision curve analysis (DCA) were used to evaluate predictive performance. The Niwa nomogram was enhanced by incorporating significant RSSI parameters and was internally validated using k-fold cross-validation. Maximum ureteral attenuation below the stone (UABSmax), ureter diameter above the stone (UDAS) and renal pelvis diameter (RPD) were found to be associated with SWL outcome. UABSmax had the highest individual predictive value (area under the curve (AUC) 0.66), while UWT showed no significant association or predictive value. Incorporating UABSmax and RPD into the Niwa nomogram (Niwa+) marginally increased AUC (0.72 vs. 0.71) but did not lead to significant improvements in NRI or DCA. In conclusion, certain RSSI- particularly UABSmax and RPD- were associated with SWL outcome but provided limited value when added to an already validated nomogram.}, issn = {2194-7228} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_liujamesh_2025, title = {Advancing the interface between research and practice in sustainable development : A view from Political Psychology}, author = {Liu, James. H. and Hopner, Veronica and Muldoon, Orla and Khan, Sammyh}, year = {2025}, journal = {Political Psychology}, volume = {46}, number = {6}, pages = {1415--1418}, doi = {10.1111/pops.70081}, url = {2027588}, language = {eng}, publisher = {John Wiley & Sons}, issn = {0162-895X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tamkimpong_2025, title = {Advancing the interface between research and practice in sustainable development : Introduction to a multi-journal special issue}, author = {Tam, Kim-Pong and Leung, Angela Ka-yee and Khan, Sammyh and Reese, Gerhard}, year = {2025}, journal = {Asian journal of social psychology (Print)}, volume = {28}, number = {4}, doi = {10.1111/ajsp.70067}, url = {2016285}, language = {eng}, publisher = {John Wiley & Sons}, issn = {1367-2223} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_prenkertfrans_2025, title = {Advocating for stewardship : Conceptualizing resources having value-in-non-use in industrial business networks}, author = {Prenkert, Frans and Carlborg, Per and Hasche, Nina}, year = {2025}, url = {1995873}, language = {eng}, keywords = {resource interaction; intrinsic value; value-per-se; value in non-use; stewardship; planetary boundaries}, abstract = {This paper explores the concept of value-in-non-use within industrial business networks, emphasizing the importance of stewardship in managing natural resources and ecosystems. Traditional theories in industrial networks often link resource value to their use in relation to other resources. However, this paper argues that some resources possess intrinsic value in their non-use, which is crucial for sustainability. By examining the relational ontology of resources, the paper proposes a framework for understanding and incorporating non-use values into business network analyses. This approach aims to protect resources from overexploitation while still allowing for economic interactions. The concept of network stewardship is introduced, advocating for institutional arrangements that recognize and preserve the non-use value of resources, thereby contributing to sustainable industrial practices.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_svantessonmia_2025, title = {Age and grit in prioritising intensive care : - a mixed-methods approach of normative challenges}, author = {Svantesson, Mia and Jarl, Gustav and Falk, Wiebke and Lars, Sandman}, year = {2025}, journal = {BMC Medical Ethics}, volume = {26}, number = {1}, doi = {10.1186/s12910-025-01305-2}, url = {2009849}, language = {eng}, publisher = {BioMed Central (BMC)}, abstract = {BACKGROUND: Intensive care unit (ICU) admissions among older patients are increasing, posing significant challenges to already strained healthcare systems. Decision-making around ICU admission in times of limited resources may provide important knowledge about difficult prioritisations, particularly for older patients. Thus, the aim was to investigate ICU-admission decisions for older patients with COVID-19.METHODS: A mixed-methods approach. We audio-recorded ten COVID Rounds and nine Moral Case Deliberations for 34 patients across three Swedish hospitals during the pandemic, and collected data from medical records of 329 patients aged ≥ 65 diagnosed with COVID-19. Data were analysed using qualitative content analysis and multiple regression.RESULTS: Among 239 patients with documented decisions in medical records, 56% included explicit justifications. The justifications included considerations of medical benefit (not-too- ill/too-ill), general condition (good/frail), age (not-too-old/high age), professional duty (benefit of the doubt/do no harm) and "worth giving it a go" (grit and will to live/lack of will and coping). A minority (31%) of decisions favoured ICU admission. Justifications supporting admission were predominantly drawn from discussions in COVID Rounds and MCDs, where patient grit was a recurring argument. In regression analyses, age ≥ 80 years was the only factor significantly associated with not being admitted to ICU and having a documented justification. Few decisions explicitly referred to COVID-19-specific factors.CONCLUSION: Our findings reflect patterns similar to pre-pandemic ICU decision-making, suggesting continuity in clinical reasoning. However, the limited documentation of justifications-especially in favour of admission-warrants attention, emphasising the need for clearer reasoning in medical records. Our findings identify chronological age as a key triage factor, normatively supported by the ethical principles of non-maleficence, justice, and Sweden's legal priority-setting principle of Needs and Solidarity-which emphasises care only when benefit is likely. We therefore advocate for national (and potentially international) guidance on triage systems that support a palliative approach for very old patients. While grit may be relevant to ICU admission due to its link to potential benefit, its use raises ethical concerns, particularly in relation to Needs and Solidarity and Human Dignity. We recommend its cautious application pending further research.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_chidiacchristine_2025, title = {Age at time of surgery does not influence outcome in idiopathic normal pressure hydrocephalus - a national quality registry study of 3082 patients}, author = {Chidiac, Christine and Sundström, N. and Tullberg, M. and Arvidsson, L. and Olivecrona, Magnus}, year = {2025}, journal = {Acta Neurochirurgica}, volume = {167}, number = {1}, doi = {10.1007/s00701-025-06717-y}, url = {2018099}, language = {eng}, publisher = {Springer}, keywords = {age; idiopathic normal pressure hydrocephalus; mrs; shunt surgery; tug}, abstract = {PURPOSE: This study aims to investigate the outcome of shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH) in relation to age at surgery, using data from the Swedish Hydrocephalus Quality Registry (SHQR). The disease affects older patients, with a mean age at diagnosis of 74 years. Since shunt surgery, which introduces a risk of serious complications, is the only available treatment, appropriate selection of patients eligible for surgery is essential. It has been suggested that higher age negatively affects outcome after shunt surgery.METHODS: Patients operated upon during January 2004-February 2022 were included. The inclusion criteria were: age ≥ 60 years and data available from ≥ 3 domains by the iNPH scale. Clinical outcomes were assessed at 3 and 12 months using the modified version of the iNPH scale (miNPH), the Timed Up-and-Go (TUG) test and the modified Rankin scale (mRS). These were related to 5-year-interval age groups. 'RESULTS: Improvement was seen in all age groups, with no statistically significant differences in outcome between age groups in miNPH score, TUG or mRS. The oldest group (> 85 years) showed significant improvements, as illustrated by miNPH scale score changes at 3 and 12 months of 4.3 (-8.1 to 21.5) and 10.1 (-6.5 to 36.8), respectively.CONCLUSIONS: This population-based study shows similarly favourable outcomes across ages, suggesting that there should be no upper age limit for shunt surgery in patients with iNPH.}, issn = {0001-6268} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_knnasteastrid_2025, title = {Age, chemotype and overwintering practices control volatile emissions in Scots pine (Pinus sylvestris) seedlings}, author = {Kännaste, Astrid and Zhao, Tao and Lindström, Anders and Långström, Bo and Niinemets, Ülo and Borg-Karlson, Anna-Karin}, year = {2025}, journal = {Scandinavian Journal of Forest Research}, doi = {10.1080/02827581.2025.2592637}, url = {2022699}, language = {eng}, publisher = {Taylor & Francis}, keywords = {pinus sylvestris (l.); mini seedling; volatile emission; glvs; chemotype; age; overwintering practices}, abstract = {Small 5 to 7 cm seedlings appear to be less damaged by pine weevils (Hylobius abietis L.), one of the most economically devastating forest pests in Europe. In attempts to understand the underlying mechanisms, volatiles (VOC) released by the whole plant and wounded phloem of Scots pine (P. sylvestris L.) seedlings were investigated during the first year of growth. The changes in the VOC due to age/developmental stage and storage regimes were determined. Majority of the seedlings (84%) represented a '3-carene chemotype' and 15% an 'alpha-pinene chemotype'. 3.5 Week-old intact or wounded seedlings emitted mainly geranyl acetone and green leaf volatiles. Proportional increase of (+)-3-carene occurred during the growth and aging of intact '3-carene seedlings', while (+/-)-alpha-pinene changed in their phloem emissions. From 9.5 week onwards, the intact seedlings began to emit 2-phenylethanol. During winter dormancy, the pine odor enriched with estragole, 3-phenylpropanol and 4-ethyl-2-methoxyphenol. The latter one, together with 4-ethylphenol, was characteristic to the over-wintered in an outdoor area (OA). These results support the hypothesis that seedling attractiveness to herbivores depend on the plant age and overwintering practices. Considering the antimicrobial properties of volatiles, overwintering of plants under natural conditions may also ensure higher disease resistance of plants.}, issn = {0282-7581} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_anderssonpernilla_2025, title = {Age Differences in Brain Functional Connectivity Underlying Proactive Interference in Working Memory}, author = {Andersson, Pernilla and Schrooten, Martien G. S. and Persson, Jonas}, year = {2025}, journal = {Human Brain Mapping}, volume = {46}, number = {5}, doi = {10.1002/hbm.70189}, url = {1950758}, language = {eng}, publisher = {John Wiley & Sons}, abstract = {Aging is typically accompanied by a decline in working memory (WM) capacity, even in the absence of pathology. Proficient WM requires cognitive control processes that can retain goal-relevant information for easy retrieval and resolve interference from irrelevant information. Aging has been associated with a reduced ability to resolve proactive interference (PI) in WM, leading to impaired retrieval of goal-relevant information. It remains unclear how age-related differences in the ability to resolve PI in WM are related to patterns of resting-state functional connectivity (rsFC) in the brain. Here, we investigated the association between PI in WM and rsFC cross-sectionally (n = 237) and 5 years longitudinally (n = 134) across the adult life span by employing both seed-based and data-driven approaches. Results revealed that the ability to resolve PI was associated with differential patterns of inferior frontal gyrus (IFG) rsFC in younger/middle-aged adults (25-60 years) and older adults (65-80 years) in two clusters centered in the vermis and caudate. Specifically, more PI was associated with stronger inferior frontal gyrus-vermis connectivity and weaker inferior frontal gyrus-caudate connectivity in older adults, while younger/middle-aged adults showed associations in the opposite directions with the identified clusters. Longitudinal analyses revealed that a reduced ability to control PI was associated with reduced inferior frontal gyrus-insula and inferior frontal gyrus-anterior cingulate cortex connectivity in older adults, while younger/middle-aged adults showed associations in the opposite direction with these clusters. Whole brain multivariate pattern analyses showed age-differential patterns of rsFC indicative of age-related structural decline and age-related compensation. The current results show that rsFC is associated with the ability to control PI in WM and that these associations are modulated by age.}, issn = {1065-9471} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_havstormtanjaelina_2025, title = {Agile Software Development Method Cargo Cult - Devising an Analytical Tool}, author = {Havstorm, Tanja Elina and Karlsson, Fredrik and Gao, Shang}, year = {2025}, journal = {Information and Software Technology}, volume = {187}, pages = {1--13}, doi = {10.1016/j.infsof.2025.107851}, url = {1988028}, language = {eng}, publisher = {Elsevier}, keywords = {agile; cargo cult; deviations; software development; social action theory; work motivation theory; empirical study}, abstract = {Context: Despite the widespread adoption of agile software development methods (ASDMs) today, many organizations struggle with effective implementation. One reason for this is that some organizations claim to use an ASDM without fully understanding its core principles, or they adhere to old practices while professing to follow a contemporary software development method. This phenomenon is sometimes referred to by practitioners as “cargo cult” (CC) behavior. However, simply labeling something as CC lacks analytical depth.Objective: This paper aims to conceptualize and validate an analytical tool for diagnosing CC and non-CC behavior in software development teams’ use of ASDMs.Method: This study uses a longitudinal ethnographic approach to conceptualize and validate the analytical tool by analyzing four agile practices used by a global industrial manufacturing company.Results: The analytical tool features eight stereotypes—three representing non-CC behaviors and five representing CC behaviors—designed to aid in the analysis of ASDM usage. The tool draws on Social Action Theory and Work Motivation Theory to capture and interpret the CC phenomenon in ASDM use. Using the stereotypes, 36 actions were categorized as CC behavior deviating from documented ASDM practices, and 23 actions as non-CC behavior because they aligned with the documented ASDM and reflected agile goals and values. The tool thus can help both researchers and practitioners gain a deeper understanding of ASDM use in organizations.Conclusion: This study advances understanding of ASDM use by moving beyond the simplistic use of the term “cargo cult”. The developed tool enables structured identification and classification of CC behaviors. The stereotypes provide a way of classifying recurring software development actions against the intended ASDM, allowing the identification of specific types of CC behaviors. The analytical tool enables managers to gain deeper insights into the underlying reasons for deviations, thereby supporting more grounded and effective agile practices within organizations.}, issn = {0950-5849} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_krishnapathisai_2025, title = {AGIR : A Framework for Mobile Robots to Join Social Group Interactions}, author = {Krishna Pathi, Sai}, year = {2025}, url = {1942862}, language = {eng}, publisher = {Örebro University}, keywords = {social group interactions; f-formations; hri; group detection; mobile robots}, abstract = {Social group interactions are a fundamental aspect of human communication and collaboration, characterized by dynamic spatial and orientational patterns. As robots become more prevalent in human environments, they are expected to adhere to social norms, including the ability to join these interactions seamlessly without causing disruptions.Motivated by the need to explore how these norms extend to robots, we investigated the behavior of teleoperators during group interactions. The findings not only demonstrated that teleoperators inherently follow these socia lnorms but also highlighted their preference for robots with autonomous capabilities to seamlessly join group interactions adhering to these norms. In this regard, this thesis presents a new and comprehensive framework named as “Autonomous Group Interactions for Robots (AGIR)”, designed to enable mobile robots to join ongoing social group interactions autonomously through an egocentric camera perspective.The AGIR framework is built upon principles from social psychology, such as Proxemics and F-formations, to ensure socially acceptable behavior. Its architecture comprises computational models for extracting spatial and orientational information, detecting groups, estimating spatial formations, and identifying optimal positions for robot in group interactions. Designed to operate in real-time using the robot’s onboard sensors, the framework is modular and adaptable to a diverse range of robotic platforms.AGIR was rigorously evaluated through experiments conducted in both simulated and real-world environments. Real-world experiments were performed in corridor, lab, and home environments. While in simulation, three scenes were developed similar to conference lobby and coffee break scenarios. Results demonstrated high accuracy in spatial and orientational estimations, group detection, F-formation predictions, and determining optimal robot positions within groups. The framework effectively enabled operating in real-time from an egocentric view and autonomously joining group interactions without disruption. AGIR lays the groundwork for robots to seamlessly integrate into human social environments, enabling practical applications in domains such as elder care, telepresence, and collaborative workspaces.}, file = {https://oru.diva-portal.org/smash/get/diva2:1942862/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tryggvasonsgeir_2025, title = {Agonistic teaching : Four principles}, author = {Tryggvason, Ásgeir}, year = {2025}, journal = {Journal of Curriculum and Pedagogy}, volume = {22}, number = {2}, pages = {279--299}, doi = {10.1080/15505170.2023.2284694}, url = {1816280}, language = {eng}, publisher = {Taylor & Francis}, keywords = {agonism; democratic education; citizenship; emotion; conflic}, abstract = {The aim of this article is to synthesize theoretical and empirical research on agonism in education into teaching principles. Agonistic theory underscores the role of conflict, emotions, and collective identities in democratic classroom discussions. Empirical studies on agonism in education provide empirical insights into how these aspects are played out in teaching practices. By synthesizing both theoretical development and empirical findings on agonism in education, this article suggests four principles for agonistic teaching. The suggested principles aim to function as a synthetization of research valuable to the research field of democratic education and as tools for teachers who want to explore the possibilities of agonism in their teaching.}, issn = {1550-5170}, file = {https://oru.diva-portal.org/smash/get/diva2:1816280/FULLTEXT01.pdf} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_lodefalkmagnus_2025, title = {AI i offentlig sektor}, author = {Lodefalk, Magnus and Engberg, Erik and Rydén, Siri and Tang, Aili}, year = {2025}, url = {2003982}, language = {swe}, publisher = {Nationalekonomiska föreningen}, abstract = {Artificiell intelligens (AI) har potential att bidra till att hantera kompetensbrist och arbetskraftsbehov i offentlig sektor. Vi undersöker med scenarioanalyser de effekter tekniken kan ha på produktivitet och arbetskraftsbehov. Dessutom analyserar vi utmaningar med tekniken. Resultaten visar på potential för både tydliga produktivitetsökningar och ett minskat arbetskraftsbehov, där även måttliga produktivitetsökningar kan leda till en ökad långsiktig tillväxttakt. För att detta ska realiseras krävs det dock omfattande insatser, inklusive kompetensutveckling och strategiskt ledarskap.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_toledoedan_2025, title = {AI Research Agents for Machine Learning : Search, Exploration, and Generalization in MLE-bench}, author = {Toledo, Edan and Hambardzumyan, Karen and Josifoski, Martin and Hazra, Rishi and Baldwin, Nicolas and Audran-Reiss, Alexis and Kuchnik, Michael and Magka, Despoina and Jiang, Minqi and Lupidi, Alisia Maria and Lupu, Andrei and Raileanu, Roberta and Shavrina, Tatiana and Niu, Kelvin and Gagnon-Audet, Jean-Christophe and Shvartsman, Michael and Sodhani, Shagun and Miller, Alexander H. and Charnalia, Abhishek and Dunfield, Derek and Wu, Carole-Jean and Stenetorp, Pontus and Cancedda, Nicola and Foerster, Jakob Nicolaus and Bachrach, Yoram}, year = {2025}, url = {2020921}, language = {eng}, keywords = {deep learning (e.g.; architectures; generative models; optimization for deep networks; foundation models; llms)}, abstract = {AI research agents are demonstrating great potential to accelerate scientific progress by automating the design, implementation, and training of machine learning models. We focus on methods for improving agents' performance on MLE-bench, a challenging benchmark where agents compete in Kaggle competitions to solve real-world machine learning problems. We formalize AI research agents as search policies that navigate a space of candidate solutions, iteratively modifying them using operators. By designing and systematically varying different operator sets and search policies (Greedy, MCTS, Evolutionary), we show that their interplay is critical for achieving high performance. Our best pairing of search strategy and operator set achieves a state-of-the-art result on MLE-bench lite, increasing the success rate of achieving a Kaggle medal from 39.6% to 47.7%. Our investigation underscores the importance of jointly considering the search strategy, operator design, and evaluation methodology in advancing automated machine learning.}, file = {https://oru.diva-portal.org/smash/get/diva2:2020921/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hrckovaandrea_2025, title = {AI Research Is Not Magic, It Has to Be Reproducible and Responsible : Challenges in the AI Field from the Perspective of Its PhD Students}, author = {Hrckova, Andrea and Renoux, Jennifer and Tolosana Calasanz, Rafael and Chuda, Daniela and Tamajka, Martin and Simko, Jakub}, year = {2025}, volume = {16319}, pages = {451--466}, doi = {10.1007/978-3-032-11108-1_34}, url = {2028763}, language = {eng}, publisher = {Springer}, abstract = {Unlocking the full societal potential of artificial intelligence demands a fundamental shift towards responsible and reproducible research. Understanding that PhD students are pivotal in conducting and reproducing experiments, we investigated the challenges of 28 AI PhD candidates from 13 European countries. We identify three critical areas where current practices fall short: (1) the findability and quality of AI resources such as datasets, models, and experiments; (2) the difficulties in replicating the experiments in AI papers; (3) and the lack of trustworthiness and interdisciplinarity. After uncovering some of the underlying reasons behind the challenges, we propose a combination of social and technical recommendations to overcome the identified challenges and foster a more transparent and reliable AI research ecosystem. Socially, we recommend the general adoption of reproducibility initiatives in AI conferences and journals, as well as improved interdisciplinary scientific collaboration, especially in data governance practices. On the technical front, we call for enhanced tools to better support versioning control of datasets and code, and a computing infrastructure that facilitates the sharing and discovery of AI resources, as well as the sharing, execution, and verification of experiments.}, file = {https://oru.diva-portal.org/smash/get/diva2:2028763/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kckemannuwe_2025, title = {AIDDL : The AI Domain Definition Language for integrated AI systems}, author = {Köckemann, Uwe}, year = {2025}, journal = {SoftwareX}, volume = {31}, doi = {10.1016/j.softx.2025.102259}, url = {1988786}, language = {eng}, publisher = {Elsevier}, keywords = {composite artificial intelligence; domain definition language}, abstract = {Practical applications of artificial intelligence frequently benefit from the strengths of multiple individual AI approaches. However, these approaches use different representations for data and models and thus are often difficult to combine. To address this gap we created the AI Domain Definition Language (AIDDL) language and framework. The language allows to express AI models, data, and problems, as well as intermediate representations tailored to specific applications. The framework, on the other hand, allows us to define translations between models and data and offers a variety of solver for AI problems. As a result, the AIDDL framework allows to build integrated AI systems tailored to complex problems and composed of well understood and studied AI algorithms.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_borgalexander_2025, title = {AI-Enhanced Social Robotic Versus Computer-Based Virtual Patients for Clinical Reasoning Training in Medical Education : Observational Crossover Cohort Study}, author = {Borg, Alexander and Schiött, Jonathan and Ivegren, William and Gentline, Cidem and Huss, Viking and Hugelius, Anna and Jobs, Benjamin and Espinosa, Fabricio and Ruiz, Mini and Edelbring, Samuel and Georg, Carina and Skantze, Gabriel and Parodis, Ioannis}, year = {2025}, journal = {Journal of Medical Internet Research}, volume = {27}, doi = {10.2196/82541}, url = {2017272}, language = {eng}, publisher = {JMIR Publications}, keywords = {clinical reasoning; educational technology; large language models; medical education; social robotics; virtual patients}, abstract = {BACKGROUND: Virtual patient (VP) simulations can be used to practice clinical reasoning (CR) in controlled learning environments. Traditional computer-based VP platforms often lack the authenticity and interactivity required for effective CR training. Artificial intelligence (AI)-enhanced social robotic VPs can enhance realism and engagement; however, quantitative evidence comparing them with conventional VP platforms remains limited. OBJECTIVE: We compared medical students' experience of an AI-enhanced social robotic versus a conventional computer-based VP platform regarding the extent to which the design characteristics of the respective platform facilitate CR skill training.METHODS: This observational crossover cohort study involved 178 sixth-semester medical students at Karolinska Institutet, Stockholm, Sweden (response rate: 42.3%; 178 of 421 invited students; Spring 2024-Spring 2025), who experienced both a large language model-enhanced social robotic VP platform supporting dialogue (social artificial intelligence-enhanced robotic interface [SARI]) and a conventional computer-based VP platform (virtual interactive case [VIC]) during their clinical rotation within rheumatology. Platform order was determined by clinical rotation scheduling. VP design was evaluated using a validated questionnaire across 5 domains: authenticity, professional approach, coaching quality, learning effects, and overall judgment. Students' CR training preferences were assessed using categorical responses and a Visual Analogue Scale, where a lower score favored SARI and a score of 5 indicated equal preference between platforms.RESULTS: SARI outperformed VIC across all 5 VP design domains. Students rated SARI higher for authenticity (median 4.0, IQR 3.5-4.5 vs 3.0, IQR 2.5-3.5; P<.001), professional approach (median 4.5, IQR 4.0-4.8 vs 4.0, IQR 3.5-4.5; P<.001), coaching quality (median 4.3, IQR 4.0-4.7 vs 4.0, IQR 3.7-4.7; P<.001), learning effect (median 4.4, IQR 4.0-5.0 vs 4.0, IQR 3.5-4.5; P<.001), and overall judgment (median 5.0, 4.0-5.0 vs 4.0, IQR 4.0-5.0; P<.001). Students strongly preferred SARI for CR training (72% vs 14%; odds ratio [OR] 27.1, 95% CI 14.3-53.7; P<.001), with Visual Analogue Scale scores confirming this preference (median 3.0, IQR 2.0-5.0; P<.001). Preferences were consistent across most subgroups (sex, prior VP experience, and platform order); in 2 subgroups, the difference was not significant, that is, students with prior VP experience (62% vs 38%; OR 2.6; 95% CI 0.8-8.9; P=.11) and students first introduced to VIC (55% vs 45%; OR 1.5; 95% CI 0.7-2.9; P=.33).CONCLUSIONS: Our findings provide the first quantitative evidence that AI-enhanced social robotic VPs offer superior design characteristics than conventional computer-based platforms for CR training in medical education. These results support the use of AI-driven social robots for VP simulations to better prepare medical students for real clinical encounters, and warrant future research on objective CR skill outcomes and long-term transfer to clinical practice. Unlike previous qualitative studies examining each platform separately, this study provides the first quantitative comparison of design characteristics between AI-enhanced social robotic and conventional computer-based VPs.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gilescloverjack_2025, title = {‘Aiming for Integration’ — Acculturation Strategies Among Refugee Youth in Sweden : A Qualitative Study Using a Resilience Framework}, author = {Giles, Clover Jack and Västhagen, Maja and Enebrink, Pia and Ghaderi, Ata and Oppedal, Brit and Khan, Sammyh}, year = {2025}, journal = {Journal of Community and Applied Social Phychology}, volume = {35}, number = {2}, doi = {10.1002/casp.70066}, url = {1939282}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {acculturation; refuge youth; resilience; resources; risk; sweden}, abstract = {In 2022, one in 20 minors in Sweden had a refugee background. As most refugees do not return to their countries of origin, understanding successful resettlement should be prioritised. Acculturation and psychological resilience are useful concepts, as both acknowledge the interplay between individual and contextual factors in sociocultural adjustment. However, less is known about the role of resilience in the selection and maintenance of acculturation strategies, especially among refugee youth. This qualitative interview study aimed to investigate how acculturation strategies may be shaped by risks and resources using a soci-oecological resilience framework. The narratives of 22 refugee youth in Sweden were explored using reflexive thematic analysis. Deductive coding, informed by an established socioecological model of immigrant youth adaptation, examined the interplay between individual acculturation motivations and contextual factors. The analysis resulted in six themes: (1) war, peace, and opportunities (global forces); (2) (dis)orientation and comparisons (socio-political context); (3) aiming for integration (individual/motivation to acculturate); (4) learning to belong (microsystem—school); (5) inclusion and exclusion (microsystem—friends); (6) support, conflict, and accord (microsystem—family). The analysis highlights how resilience resources may enable maintenance, while frustration and discrimination can pose a risk to the maintenance of a preferred integration strategy.}, issn = {1052-9284}, file = {https://oru.diva-portal.org/smash/get/diva2:1939282/FULLTEXT01.pdf} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_lodefalkmagnus_2025_1, title = {Algoritmer för allmän nytta : en ESO-rapport om AI, produktivitet och arbetskraftsbehovet i offentlig sektor}, author = {Lodefalk, Magnus and Engberg, Erik and Tang, Aili}, year = {2025}, url = {2012903}, language = {swe}, publisher = {Expert Group on Public Economics} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fernndezdelacruzlorena_2025, title = {All-Cause and Cause-Specific Mortality in Tourette Syndrome and Chronic Tic Disorder}, author = {Fernández de la Cruz, Lorena and Isomura, Kayoko and Kuja-Halkola, Ralf and Lichtenstein, Paul and Larsson, Henrik and Chang, Zheng and D'Onofrio, Brian M. and Brikell, Isabel and Sidorchuk, Anna and Mataix-Cols, David}, year = {2025}, journal = {Movement Disorders}, volume = {40}, number = {2}, pages = {335--344}, doi = {10.1002/mds.30084}, url = {1921979}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {tourette syndrome; chronic tic disorder; mortality; suicide}, abstract = {BACKGROUND: Tourette syndrome (TS) and chronic tic disorder (CTD) may be associated with an increased risk of mortality, but specific causes of death are poorly understood. OBJECTIVES: In this matched cohort and sibling cohort study, we estimated the risk of all-cause and cause-specific mortality in individuals with TS/CTD, compared with unaffected matched individuals and unaffected full siblings.METHODS: We identified all individuals diagnosed with TS/CTD in the Swedish National Patient Register who were living in the country between 1973 and 2020 and matched them (1:10) to individuals without TS/CTD from the general population. We also identified their siblings without TS/CTD. All-cause and cause-specific mortality outcomes, based on the International Classification of Diseases codes, were extracted from the Cause of Death Register. Covariates included sociodemographic variables and psychiatric disorders. Risks of mortality were estimated using Cox proportional hazards regression models.RESULTS: We included 10,280 individuals with TS/CTD and 102,800 matched individuals without TS/CTD. In adjusted models, individuals with TS/CTD had an 86% increased hazard of all-cause mortality (hazard ratio: 1.86, 95% confidence interval: 1.65-2.11). The increased risk was observed for both natural (particularly nervous, digestive, and respiratory system diseases) and unnatural causes of death (including suicides and accidents). The sibling comparison showed similar results, indicating that the associations were unlikely to be explained by familial confounding.CONCLUSIONS: Individuals with TS/CTD are at increased risk of death due to both natural and unnatural causes. As some of these deaths are potentially preventable, greater focus on the somatic health of individuals with TS/CTD is warranted.}, issn = {0885-3185} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_thunstrmsofia_2025, title = {All-cause mortality and death by aortic dissection in women with Turner syndrome : a national clinical cohort study}, author = {Thunström, Sofia and Thunström, Erik and Naessén, Sabine and Berntorp, Kerstin and Laczna Kitlinski, Margareta and Ekman, Bertil and Wahlberg, Jeanette and Bergström, Ingrid and Isaksson, Magnus and Basic, Carmen and Svanvik, Teresia and Bryman, Inger and Landin-Wilhelmsen, Kerstin}, year = {2025}, journal = {American Heart Journal}, volume = {281}, pages = {1--9}, doi = {10.1016/j.ahj.2024.11.007}, url = {1920330}, language = {eng}, publisher = {Elsevier}, keywords = {turner syndrome; aortic dissection; mortality}, abstract = {BACKGROUND: Turner syndrome (TS) is a complex genetic disorder with raised mortality. Our objective was to investigate mortality and causes of death in TS.METHODS: A matched retrospective observational study of women with TS recruited from the Turner centers in Sweden were conducted. A total of 472 women with TS, ≥ 16 years old with a cytogenetically verified diagnosis and 2357 controls, matched for birthyear and sex, were examined and followed since 1995 for up to 26 years. Survival analyses were performed with Cox proportional hazard models. Kaplan-Meier curves were generated. Cumulative incidence rates were evaluated by competing risks analysis, using cumulative incidence function.RESULTS: During a mean follow-up of 17 years, 35 (7.4%) women with TS and 70 (3.0%) controls died. All-cause mortality was elevated in TS, hazard ratio (HR) 2.90 (95% CI 1.92-4.37), mainly due to circulatory diseases and notably aortic dissection, with HR of 9.11 (95% CI 4.54-18.25) and 21.79 (95% CI 4.62-102.82), respectively. Aortic dissection was the single largest cause of death in TS, accounting for 23% (8/35) of total deaths. Death by cancer or external causes were not raised in TS. In individuals below 45 years of age death, aortic dissections were greatly increased compared to controls, HR 55.59 (95% CI 2.33-1325.69). From the ages 46 to 80 years a notably higher risk of dying by heart diseases, aortic dissection excluded, was shown in TS compared to controls HR, 7.7 (2.65-22.36). The median survival time was 8 years shorter in TS compared to controls.CONCLUSIONS: The increased mortality in TS was mainly driven by aortic dissections in the young and by heart diseases in the older. Healthcare professionals should prioritize detection and monitoring, with emphasis on cardiovascular diseases.}, issn = {0002-8703} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mairpadyshambatsrikanth_2025, title = {Alpha-toxin-elicited CX3CL1 release in Staphylococcus aureus pneumonia impairs bactericidal function of human monocytes}, author = {Mairpady Shambat, Srikanth and Chen, Puran and Barilla, Rocky M. and Huemer, Markus and Snäll, Johanna and Welin, Amanda and Cohen, Taylor S. and Takahashi, Virginia and Berry, Samuel B. and Gómez-Mejia, Alejandro and Schweizer, Tiziano A. and Cunoosamy, Danen M. and Cajander, Sara and Lourda, Magda and Özenci, Volkan and Maggio, Ewerton Marques and Schüpbach, Reto A. and Strålin, Kristoffer and Zinkernagel, Annelies S. and Norrby-Teglund, Anna and Svensson, Mattias}, year = {2025}, journal = {mBio}, volume = {16}, number = {11}, doi = {10.1128/mbio.02689-25}, url = {2006260}, language = {eng}, publisher = {American Society for Microbiology}, keywords = {adam10; cx3cl1; staphylococcus aureus; chemotaxis; fractalkine; monocytes; pneumonia; α-toxin}, abstract = {Staphylococcus aureus is an important human pathogen causing severe invasive infections. Pathogenesis is attributed to a wide array of virulence factors, including several potent exotoxins such as the pore-forming α-toxin. In this study, we found that patients with S. aureus respiratory tract infections had elevated CX3CL1 levels in airway fluid and plasma. Using human-organotypic lung models, we observed that stimulation of lung epithelium with α-toxin induces an intensified CX3CL1 expression apically in the epithelium as well as the release of CX3CL1. Blocking α-toxin or ADAM10 activity in organotypic lung using an α-toxin-blocking antibody or a specific ADAM10 inhibitor confirmed their role in modulating CX3CL1 cleavage and release. Analyses of CD14+ human monocytes in combination with a CX3CR1 inhibitor revealed that α-toxin-mediated CX3CL1 release induces CX3CL1-dependent chemotaxis. In line with these data, lung tissue from patients with S. aureus respiratory tract infection showed elevated CX3CL1 and CD14 staining as compared with tissue from patients with non-infectious lung diseases. Functional studies of monocytes showed that CX3CL1 released by lung models resulted in upregulated CD83 and downregulated CD86, as well as impaired killing of phagocytosed S. aureus. Furthermore, stimulation of monocytes with soluble CX3CL1 hampered their reactive-oxygen and nitric-oxide production. Taken together our data show that S. aureus triggers the release of lung epithelial CX3CL1, and we identify an immunomodulatory effect of α-toxin involving its cytotoxic and ADAM10-interacting properties, inducing CX3CL1 release leading to impaired monocyte effector function.IMPORTANCEExotoxins are essential virulence factors for the pathobiont S. aureus and contribute toward severe invasive infections such as pneumonia. S. aureus α-toxin is a pore-forming exotoxin that causes host cell lysis and severe lung pathology. We found that α-toxin drives the release of membrane-bound chemokine CX3CL1 by involving ADAM10-mediated proteolytic activity. Furthermore, the release of CX3CL1 modulated immune responses locally, as demonstrated by enhanced monocyte migration and reduced capacity of monocytes to kill ingested bacteria. CX3CL1-induced reduction in bacterial killing coincided with impaired production of reactive oxygen and nitric oxide species. This reveals a novel mechanism in the pathogenesis of S. aureus lung infections involving α-toxin-induced release of CX3CL1, leading to impaired bacterial killing by monocytes.}, issn = {2161-2129} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_rodanakimaria_2025, title = {Alterations in pubertal timing : physiological aspects and long-term consequences}, author = {Rodanaki, Maria}, year = {2025}, url = {1938459}, language = {eng}, publisher = {Örebro University}, keywords = {puberty; pubertal disorders; precocious puberty; delayed puberty; ghrelin; kisspeptin; socioeconomic consequences; gnrh}, abstract = {Puberty is initiated by a series of complex mechanisms determining the age at pubertal onset. The aim of this thesis was to increase our knowledge of the role of ghrelin and kisspeptin in puberty, to describe the clinical management of delayed puberty and to study the long-term socioeconomic consequences of delayed male puberty.Study I and II were both based on a population of 13 girls with suspected central precocious puberty, who underwent a modified gonadotropin-releasing hormone stimulation test twice in a randomized controlled setting. Neither ghrelin nor kisspeptin plasma levels differed between the two tests up to 150 minutes. In Study I, different methods for the preservation of acylated ghrelin were studied as well, and the addition of the protease inhibitor AEBSF to precooled bloodsampling tubes, and cooled centrifugation within 30 minutes were found to result in the highest levels of acylated ghrelin.Study III was an observational study based on a review of the medical records of 91 boys with delayed puberty in central Sweden showing that puberty nomograms are useful diagnostic instruments, and that underlying pathology is rare but psychosocial distress is common.Study IV was a longitudinal, retrospective national cohort study, which included 1,250 men previously diagnosed with delayed puberty and 12,500 unexposed men. There was a lower likelihood of marriage or cohabitation, but no negative effects on educational achievements or labour market outcomes through early adulthood among those having had delayed puberty.Increased knowledge of the physiology and long-term consequences alterations in pubertal timing may improve the management of pubertal}, file = {https://oru.diva-portal.org/smash/get/diva2:1938459/FULLTEXT04.pdf;https://oru.diva-portal.org/smash/get/diva2:1938459/FULLTEXT05.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_leerjonatan_2025, title = {Alternative Food Hedonism}, author = {Leer, Jonatan}, year = {2025}, journal = {Gastronomica}, volume = {25}, number = {3}, pages = {62--63}, doi = {10.1525/gfc.2025.25.3.62}, url = {2023365}, language = {eng}, publisher = {University of California Press}, abstract = {We need to rethink hedonism in the age of sustainability. This is true in many domains of life and also when it comes to food. Many iconic foods associated with deliciousness in the meat-and diary-focused Western gastronomy are not compatible with the green transition in foodways. We need to learn to enjoy different foods and to enjoy food differently.In this essay, I argue that philosopher Kate Soper’s concept of alternative hedonism might be a productive tool to start thinking about culinary pleasure in the age of sustainability. Soper highlights the unsustainability of contemporary ideas of pleasures which are synonymous with consumerism and lead to high levels of pollution and CO2 emissions. Soper argues that we must cultivate less-consumerist forms of hedonism (Soper 2018).I will begin by outlining Soper’s philosophy of alternative hedonism and discuss some of the critiques that could be made of it. Then, I will illustrate what alternative hedonism might look like in the culinary world and suggest that while Soper’s framework does not provide us with final answers, the concept of alternative hedonism might be a very fruitful tool to question existing ideas of pleasures and to develop novel ones.}, issn = {1529-3262} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tibergcharlotta_2025, title = {Amendment of Contaminated Soils with Biochar and Peat : Effects on Metal Solubility and Uptake in Grass and Earthworms in a Field Trial}, author = {Tiberg, Charlotta and Kleja, Dan B. and Sjöstedt, Carin and Fröberg, Mats and Rijk, Ingrid and Dahlin, A. Sigrun and Larsson, Maria and Ekblad, Alf and Sjöberg, Viktor and Enell, Anja}, year = {2025}, journal = {Environments}, volume = {12}, number = {11}, doi = {10.3390/environments12110447}, url = {2017962}, language = {eng}, publisher = {MDPI}, keywords = {lysimeter; batch test; sustainable remediation; trace elements; copper; lead; mercury; zinc; barium; chromium}, abstract = {The effectiveness of biochar amendment for remediation purposes depends on many factors related to the biochar and the contaminated site. Therefore, each application must be evaluated site-specifically. To facilitate full-scale implementation, more information from field studies on biochar-amended contaminated sites, as well as cost-effective approaches to evaluate the remediation efficacy of specific biochar materials are needed. We studied the effects of biochar and peat on metal solubility and bioavailability in a contaminated soil in a fully factorial field trial. The biochar was produced from wood via gasification in a floating fixed-bed reactor at 750 degrees C. Soil solutions from field-installed lysimeters, grass (Lolium perenne L), and earthworms (Eisenia fetida) were analyzed. In addition, a standardized batch leaching test (ISO 21268-2:2019) was performed to evaluate its feasibility to mimic soil solution concentrations. The results showed that biochar generally reduced the solubility and uptake of cationic metals. In situ solubility of Cu and Hg was reduced more than 80%, and Zn up to 70%. Soil solution concentrations of Cr increased in biochar-amended soils, but this effect was reduced by peat. Peat had small effects on in situ solubility of other metals. For cations, the batch test showed the same trends as the soil solution, with biochar decreasing solubility. However, mobilization of colloids during shaking in the batch test induced artefacts, leading to an overestimation of the solubility of some metals, especially Pb and Hg, an effect that was enhanced by peat applications.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_appelbangshjcarolina_2025, title = {An Agile Mindset in a VUCA-World}, author = {Appel Bangshøj, Carolina and Havstorm, Tanja Elina and Algulin, Åsa}, year = {2025}, pages = {223--228}, doi = {10.1007/978-3-031-72781-8_26}, url = {1902571}, language = {eng}, publisher = {Springer Nature}, keywords = {agile mindset; agile software development methods; project success; software development; vuca}, abstract = {As the world is heading into a new era of software development (SD) an Agile Mindset (AM) has been seen to provide valuable underlying guiding elements to navigate an increasingly interconnected, turbulent, and dynamic business landscape, a VUCA-world. This study investigates the topic of agile methods and an AM through multiple-case studies with IT professionals from four tech companies. The study gathers early-stage research data to better understand what an agile SD team member does on an everyday basis in their work to exercise and achieve an AM, and what factors in the organization are impacting them in being able to do so. VUCA has been utilized as a conceptual background through which the findings – AM means and influences - have been identified, concluding that there is still much to be harnessed and learned about the elements of an AM that can improve project success outcomes.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kladivkokamil_2025, title = {An Analysis of UK Households’ Directional Forecasts of Interest Rates}, author = {Kladivko, Kamil and Österholm, Pär}, year = {2025}, journal = {Journal of Business Cycle Research}, volume = {20}, pages = {423--442}, doi = {10.1007/s41549-024-00103-w}, url = {1927496}, language = {eng}, publisher = {Springer}, keywords = {bank of england; e47; forecast evaluation; g17; inflation attitudes survey; survey data}, abstract = {In this paper, we evaluate the directional interest-rate forecasts of UK households from the Bank of England’s Inflation Attitudes Survey. Employing a test for directional forecast accuracy and data on the survey balance ranging from 1999Q4 to 2023Q2, we find that the balance is not able to predict in which direction the interest rate will move over the coming year. In addition, regression models based on the balance are not able to generate forecasts for the quantitative change in the interest rate over the coming twelve months that have higher precision than a naïve forecast of no change. In order to provide information as to whether our findings are due to the inherent difficulty when it comes to forecasting interest rates or if households are not very insightful regarding interest rates, we investigate – again using data on the survey balance and testing for directional accuracy – whether households have been able to correctly assess the directional change of the interest rate over the previous twelve months; our results indicate some amount of “literacy” among the households regarding the interest rates that they face. Finally, analyses based on individual-response level data suggest that literacy regarding interest rates – proxied by the respondent having been correct regarding the directional change over the previous twelve months – does not appear helpful when forecasting.}, issn = {2509-7970} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_vinayakpatilrajesh_2025, title = {An Autonomous Mobile Robot Simulation using Navigation (NAV-2) and Simultaneous Localization and Mapping (SLAM) in ROS2}, author = {Vinayak Patil, Rajesh}, year = {2025}, doi = {10.1201/9781003538271-14}, url = {1993494}, language = {eng}, publisher = {CRC Press}, abstract = {This chapter proposes a method for simulating a mobile robot in ROS2 by combining the NAV2 and SLAM frameworks. The main objective is to simulate and test a mobile robot in a controlled simulated environment. The robot model and its interactions with surrounding obstacles are investigated in the study using a simulated environment constructed with Gazebo. Real-time data collection is incorporated into the robot model using depth cameras and LiDAR; this data is examined and presented in RVIZ. The outcomes demonstrate that path planning and mapping are successful, enabling the robot to navigate on its own while dodging hazards. It demonstrates how well NAV2 and SLAM complement one another to enhance the autonomy and usefulness of autonomous mobile robots (AMRs) in their natural environments.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sennesaeljoryan_2025, title = {An Environmentally Friendly Carbon-Printed Contactless Smart Diaper}, author = {Sennesael, Joryan and Moerman, Arno and Bossuyt, Frederick and Vandecasteele, Bjorn and Raepsaet, Charlotte and Beeckman, Dimitri and Rogier, Hendrik and Torre, Patrick Van}, year = {2025}, journal = {IEEE Sensors Journal}, volume = {25}, number = {2}, pages = {3309--3319}, doi = {10.1109/jsen.2024.3505775}, url = {1918399}, language = {eng}, publisher = {IEEE}, keywords = {smart diapers; moisture sensing; disposable sensors}, issn = {1530-437X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_khanwaqar_2025, title = {An explainable and efficient deep learning framework for EEG-based diagnosis of Alzheimer's disease and frontotemporal dementia}, author = {Khan, Waqar and Khan, Muhammad Shahbaz and Qasem, Sultan Noman and Ghaban, Wad and Saeed, Faisal and Hanif, Muhammad and Ahmad, Jawad}, year = {2025}, journal = {Frontiers in Medicine}, volume = {12}, doi = {10.3389/fmed.2025.1590201}, url = {1989231}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {explainable ai; xai; alzheimer's disease; temporal convolutional networks; long short-term memory; frontotemporal dementia; eeg; mental disorders}, abstract = {The early and accurate diagnosis of Alzheimer's Disease and Frontotemporal Dementia remains a critical challenge, particularly with traditional machine learning models which often fail to provide transparency in their predictions, reducing user confidence and treatment effectiveness. To address these limitations, this paper introduces an explainable and lightweight deep learning framework comprising temporal convolutional networks and long short-term memory networks that efficiently classifies Frontotemporal dementia (FTD), Alzheimer's Disease (AD), and healthy controls using electroencephalogram (EEG) data. Feature engineering has been conducted using modified Relative Band Power (RBP) analysis, leveraging six EEG frequency bands extracted through power spectrum density (PSD) calculations. The model achieves high classification accuracies of 99.7% for binary tasks and 80.34% for multi-class classification. Furthermore, to enhance the transparency and interpretability of the framework, SHAP (SHapley Additive exPlanations) has been utilized as an explainable artificial intelligence technique that provides insights into feature contributions.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_arvidssonlindvallmialinn_2025, title = {An Exploratory Study About Gender Perspective of Quality of Life, in the Midlife After Stroke : 15th World Congress on Brain Injury, Montreal, Canada, 19-22, 2025}, author = {Arvidsson Lindvall, Mialinn and Jarl, Gustav and Simpson, Grahame and Matérne, Marie and Appelros, Peter}, year = {2025}, journal = {Brain Injury}, volume = {39}, number = {Sup. 1}, pages = {S72--S72}, url = {2005807}, language = {eng}, publisher = {Informa Healthcare}, issn = {0269-9052} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alnerknutssongabriella_2025, title = {An institutional understanding of child Welfare workers' handling of suspected violence against children in families involved in family law disputes in Sweden}, author = {Alner Knutsson, Gabriella and Lindahl, Robert}, year = {2025}, journal = {Journal of Public Child Welfare}, doi = {10.1080/15548732.2025.2544124}, url = {1991380}, language = {eng}, publisher = {Routledge}, keywords = {child welfare; child protection; violence; family law disputes; institutional theory}, abstract = {The aim of this study is to identify and analyze, from an institutional perspective, how various factors can influence how suspected violence against children is assessed and handled by CW workers when investigating families in family law disputes. Five group interviews were conducted comprising 18 investigative CW workers in Sweden. CW workers' case handling is framed by both regulative, normative and cultural-cognitive elements. Across all elements, the family law dispute influences CW workers' handling of suspected violence by incorporating elements that are prevalent in the Family Law System (FLS). This can be understood in terms of how organizations seek legitimacy.}, issn = {1554-8732} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_beecheymeredith_2025, title = {An international analysis of the trend five-year government bond rate}, author = {Beechey, Meredith and Österholm, Pär and Poon, Aubrey}, year = {2025}, journal = {Scottish Journal of Political Economy}, volume = {72}, number = {3}, doi = {10.1111/sjpe.12381}, url = {1954841}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {bayesian estimation; unobserved components model}, abstract = {Employing an unobserved components stochastic volatility model, we estimate the trend 5-year government bond rate in Canada, Norway, Sweden, Switzerland, the United Kingdom and the United States. Our results suggest that the estimated trend rate has decreased substantially between 2000 and 2020 in all six countries. In Norway, Switzerland and the United Kingdom, the trend rate has increased non-negligibly since 2020; in Canada, Sweden and the United States, the trend rate has not been affected much by the increase in the actual 5-year government bond rate. At the end of the sample, none of the countries has a trend rate higher than 3%. The model hence suggests that the 5-year government bond rate will be fairly low in the medium-to-long run.}, issn = {0036-9292} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_clydedanieller_2025, title = {An international Delphi consensus on patient preparation for metabolic and bariatric surgery}, author = {Clyde, Danielle R. and Adib, Reza and Baig, Sarfaraz and Bhasker, Aparna G. and Byrne, James and Cameron, David and Catalain, Copaescu and Clare, Ken and de Beaux, Andrew and Drummond, Gillian and Fawal, Hayssam and Fried, Martin and Ghanem, Omar and Graham, Yitka and Goel, Ramen and Hopkins, George and Husain, Farah and Joyce, Brian and Kermansaravi, Mohammad and Kothari, Shanu and Kow, Lilian and Leite, Silvia and Madhok, Brij and Mahon, David and Miller, Karl and Miras, Alex and Moussa, Osama and Neto, Manoel G. and Nimeri, Abdelrahman and O'Kane, Mary and Parmar, Chetan and Peterli, Ralph and Poggi, Luis and Saliminen, Paulina and Sarkar, Rupa and Shenfine, Jon and Sogg, Stephanie and Stenberg, Erik and Suter, Michel and Taha, Safwan and Tahrani, Abd and Vilallonga, Ramon and Voon, Kelvin and Welbourn, Richard and Zerrweck, Carlos and Lamb, Peter and Mahawar, Kamal K. and Yang, Wah and Robertson, Andrew G. N.}, year = {2025}, journal = {Clinical Obesity}, volume = {15}, number = {2}, doi = {10.1111/cob.12722}, url = {1921462}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {delphi; metabolic and bariatric surgery; perioperative}, abstract = {Global obesity rates have risen dramatically, now exceeding deaths from starvation. Metabolic and bariatric surgery (MBS), initially for severe obesity (BMI ≥35 kg/m2), is performed globally over 500 000 times annually, offering significant metabolic benefits beyond weight loss. However, varying eligibility criteria globally impact patient care and healthcare resources. Updated in 2022, ASMBS and IFSO guidelines aim to standardise MBS indications, reflecting current understanding and emphasising comprehensive preoperative assessments. Yet, clinical variability persists, necessitating consensus-based recommendations. This modified Delphi study engaged 45 global experts to establish consensus on perioperative management in MBS. Experts selected from bariatric societies possessed expertise in MBS and participated in a two-round Delphi protocol. Consensus was achieved on 90 of 169 statements (53.3%), encompassing multidisciplinary team composition, patient selection criteria, preoperative testing, and referral pathways. The agreement highlighted the critical role of comprehensive preoperative assessments and the integration of healthcare professionals in MBS. These findings offer essential insights to standardise perioperative practices and advocate for evidence-based guidelines in MBS globally. The study underscores the need for unified protocols to optimise outcomes and guide future research in MBS.}, issn = {1758-8103} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_doriamario_2025, title = {An International Expert-Based CONsensus on Indications and Techniques for aoRtic balloOn occLusion in the Management of Ruptured Abdominal Aortic Aneurysms (CONTROL-RAAA)}, author = {D'Oria, Mario and Lembo, Rosalba and Hörer, Tal M. and Rasmussen, Todd and Mani, Kevin and Parlani, Gianbattista and Ierardi, Anna Maria and Veraldi, Gian Franco and Melloni, Andrea and Bonardelli, Stefano and Lepidi, Sandro and Bertoglio, Luca}, year = {2025}, journal = {Journal of Endovascular Therapy}, volume = {32}, number = {5}, pages = {1623--1633}, doi = {10.1177/15266028231217233}, url = {1820483}, language = {eng}, publisher = {Sage Publications}, keywords = {delphi consensus; aortic aneurysm; balloon occlusion; ruptured aneurysm}, abstract = {OBJECTIVE: To report on the recommendations of an expert-based consensus on the indications, timing, and techniques of aortic balloon occlusion (ABO) in the management of ruptured abdominal aortic aneurysms (rAAA).METHODS: Eleven facilitators created appropriate statements regarding the study issues that were voted on using a 4-point Likert scale with open-comment fields, by a selected panel of international experts (vascular surgeons and interventional radiologists) using a 3-round modified Delphi consensus procedure (study period: January-April 2023). Based on the experts' responses, only the statements reaching grade A (full agreement ≥75%) or B (overall agreement ≥80% and full disagreement <5%) were included in the final study report. The consistency of each round's answers was also graded using Cohen's kappa, the intraclass correlation coefficient, and, in case of double resubmission, Fleiss kappa.RESULTS: Sixty-three experts were included in the final analysis and voted on 25 statements related to indication and timing (n=6), and techniques (n=19) of ABO in the setting of rAAA. Femoral sheath or ABO should be preferably placed in the operating room, via a percutaneous transfemoral access, on a stiff wire (grade B, consistency I), ABO placement should be suprarenal and last less than 30 minutes (grade B, consistency II), postoperative peripheral vascular status (grade A, consistency II) and laboratory testing every 6 to 12 hours (grade B, consistency) should be assessed to detect complications. Formal training for ABO should be implemented (grade B, consistency I). Most of the statements in this international expert-based Delphi consensus study might guide current choices for indications, timing, and techniques of ABO in the management of rAAA. Clinical practice guidelines should incorporate dedicated statements that can guide clinicians in decision-making.CONCLUSIONS: At arrival and during both open or endovascular procedures for rAAA, selective use of intra-aortic balloon occlusion is recommended, and it should be performed preferably by the treating physician in aortic pathology.CLINICAL IMPACT: This is the first consensus study of international vascular experts aimed at defining the indications, timing, and techniques of optimal use of ABO in the clinical setting of rAAA. Aortic occlusion by endovascular means (or ABO) is a quick procedure in properly trained hands that may play an important role as a temporizing measure until the definitive aortic repair is achieved, whether by endovascular or open means. Since data on its use in hemodynamically unstable patients are limited in the literature, owing to practical challenges in the performance of well-conducted prospective studies, understanding real-world use by experts is of importance in addressing critical issues and identifying main gaps in knowledge.}, issn = {1526-6028} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_khanolainendaria_2025, title = {An International Investigation of Variability in Teacher Perceptions of Bias-Based Bullying and their Likelihood of Intervening}, author = {Khanolainen, Daria and Hall, Andrew and Craig, Wendy and Trach, Jessica and Noetzel, Jared and Starosta, Lindsay and Dhungana-Sainju, Karla and Bjärehed, Jonas and Thornberg, Robert and Bayram Özdemir, Sevgi and Bjärehed, Marlene and Görzig, Anke and Wright, Michelle and Swearer, Susan and Hymel, Shelley}, year = {2025}, doi = {10.1007/s42380-025-00285-6}, url = {1924678}, language = {eng}, publisher = {Springer}, keywords = {bias-based bullying; identity-based bullying; teachers’ perceptions; teacher beliefs; teachers’ intervention}, abstract = {Bias-based bullying (i.e., bullying due to marginalized identities) is a significant and ongoing challenge within contemporary educational settings. Teachers are crucial in mitigating such harmful behaviors and cultivating positive peer relationships. The present study explores teachers’ perceptions of and intervention intentions in bias-based bullying situations across diverse cultural and educational settings. Using a between-subjects experimental design, primary and secondary teachers from 13 international sites located in Africa, Asia, Australia, Europe, and North America (n = 4990) were randomly assigned to read a hypothetical vignette depicting student victimization based on their ethnicity, learning difficulties, physical appearance, gender expression, or sexual orientation. Multilevel linear models revealed that teachers’ perceptions varied depending on the type of bias-based bullying, such that when teachers were presented with a situation of bullying based on gender expression or sexual orientation, they reported lower levels of perceived responsibility, self-efficacy, and importance of responding when compared to other types of bullying. At the same time, teachers were less likely to blame the victim of bullying and expressed greater empathy towards involved students when being presented with a situation of weight-based bullying. However, there were no significant differences in rated intervention intentions across conditions. Results have important implications for teacher education and development, as well as for existing anti-bullying intervention programs.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_saksenasanjeev_2025, title = {An international physician survey of current ablation practices in atrial fibrillation : An AIM-AF substudy}, author = {Saksena, Sanjeev and Slee, April and Merino, Jose L. and Goette, Andreas and Boriani, Giuseppe and Kowey, Peter R. and Piccini, Jonathan P. and Reiffel, James A. and Blomström-Lundqvist, Carina and Camm, A. John}, year = {2025}, journal = {Heart Rhythm}, volume = {22}, number = {9}, pages = {2174--2182}, doi = {10.1016/j.hrthm.2024.10.044}, url = {2006792}, language = {eng}, publisher = {Elsevier}, keywords = {atrial fibrillation; practice guidelines; catheter ablation; antiarrhythmic drugs; physician practice; quality of care; treatment of arrhythmias; antiarrhythmic therapy}, abstract = {BACKGROUND: Practice guidelines recommend ablation (ABL) in atrial fibrillation (AF) for rhythm control. Guidance for antiarrhythmic drugs (AADs) post-ABL is limited.OBJECTIVE: The purpose of this study was to determine AAD and ABL practices in the United States and Europe.METHODS: An online survey of experienced cardiologists (CDs) (n = 360) and interventional electrophysiologists (EPs) (n = 269) was conducted. AAD-and ABL-related survey questions and responses were analyzed.RESULTS: ABL was preferred more often as first-line AF therapy (Rx) by US CDs/EPs (P <=.001). ABL was selected to avoid AAD Rx by 46% (50% CDs, 40% EPs); to prevent AF progression by 41% (36% CDs, 47% EPs); and for superior efficacy by 28% (27% CDs, 30% EPs). ABL was used by 9% in asymptomatic AF (9% CDs, 10% EPs), by 14% in subclinical AF (13% CDs, 14% EPs), and by 17% for first AF event (15% CDs, 18% EPs). Primary ABL was preferred in heart failure by 38%. Comorbidities, age, and left atrial size were limitations for ABL by 48%, 40%, and 38%, respectively. AADs were used after ABL for AF/atrial tachycardia (AT) prophylaxis by 34% for 3-6 months and 29% for 1-2 months. AADs were given fora single AF recurrence by 34%, bridging to re-ABL by 32%, and long-term Rx by 34%. AF/AT post-ABL was most often managed with amiodarone (42%-48%).CONCLUSION: ABL was frequently preferred over AADs in symptomatic AF but notably also was used for asymptomatic and subclinical AF. Post-ABL AAD Rx for AF prophylaxis or recurrence was frequent, with empiric amiodarone being the most often selected AAD.}, issn = {1547-5271} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_erikssonmats_2025, title = {An international project to enhance Parent-led pain management to Optimize neonatal Pain care : the POP Study}, author = {Eriksson, Mats and Axelin, Anna and Bachini, Fabiana and Lenells, Mikaela and Mezzalira, Elizabetta and Mäki-Asiala, Mariaana and Olsson, Emma and Palomaa, Anna-Kaija and Pölkki, Tarja and Rajala, Mari and Ullsten, Alexandra}, year = {2025}, url = {1954909}, language = {eng}, publisher = {Örebro University, Faculty of Medicine and Health}, keywords = {newborn infant; parent; pain}, abstract = {Background/ObjectiveHospitalized neonates are subjected to a high number of painful procedures every day. Cumulative poorly treated pain can have negative consequences on short and long-term outcomes, negative effects that are further amplified by infant-maternal separation. Research has shown that parents want to be part of their hospitalized infants pain management and that it is safe and effective. Yet, the implementation of parent-led pain management in neonatal care is sub-optimal. The overall aim of the project is to expand parent-led neonatal pain management, resulting in less infant pain and potentially better neonatal health outcomes, along with improved parent mental health and well-being.Method The project is carried out by an international research group with researchers and parent representatives from Canada, Finland, Italy and Sweden, and will follow the British Research Council’s framework for complex interventions. It is organized into four work packages (WPs): Theory and concept (WP1), Identifying the problem (WP2), Developing an instrument and algorithm for self-audit (WP3), and Intervention and implementation (WP4). Principles for patient-public involvement will also be followed, with parent representatives involved in planning and designing the project and when applicable in data collection and publication of results.ResultAn international team consisting of clinicians, researchers and parent partners across four countries have commenced initial work from WP1: writing a position paper, performing a literature review, and conducting an analysis of the concept of parent-led pain management.ConclusionThe POP-project builds on the contribution of parents, researchers and clinicians and has the potential to improve implementation of parent-led pain management for neonates world-wide.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_erikssonmats_2025_1, title = {An international project to enhance Parent-led pain management to Optimize neonatal Pain care : the POP Study}, author = {Eriksson, Mats and Axelin, Anna and Bachini, Fabiana and Lenells, Mikaela and Mezzalira, Elizabetta and Mäki-Asiala, Mariaana and Olsson, Emma and Palomaa, Anna-Kaija and Pölkki, Tarja and Rajala, Mari and Ullsten, Alexandra}, year = {2025}, url = {2002363}, language = {eng}, keywords = {newborn infant; parent; pain}, abstract = {Background/ObjectiveHospitalized neonates are subjected to a high number of painful procedures every day. Cumulative poorly treated pain can have negative consequences on short and long-term outcomes, negative effects that are further amplified by infant-maternal separation. Research has shown that parents want to be part of their hospitalized infants pain management and that it is safe and effective. Yet, the implementation of parent-led pain management in neonatal care is sub-optimal. The overall aim of the project is to expand parent-led neonatal pain management, resulting in less infant pain and potentially better neonatal health outcomes, along with improved parent mental health and well-being.Method The project is carried out by an international research group with researchers and parent representatives from Canada, Finland, Italy and Sweden, and will follow the British Research Council’s framework for complex interventions. It is organized into four work packages (WPs): Theory and concept (WP1), Identifying the problem (WP2), Developing an instrument and algorithm for self-audit (WP3), and Intervention and implementation (WP4). Principles for patient-public involvement will also be followed, with parent representatives involved in planning and designing the project and when applicable in data collection and publication of results.ResultAn international team consisting of clinicians, researchers and parent partners across four countries have commenced initial work from WP1: writing a position paper, performing a literature review, and conducting an analysis of the concept of parent-led pain management.ConclusionThe POP-project builds on the contribution of parents, researchers and clinicians and has the potential to improve implementation of parent-led pain management for neonates world-wide.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_omerovicelmir_2025, title = {An update on the SWITCH-SWEDEHEART study}, author = {Omerovic, Elmir and Erlinge, David and Koul, Sasha and Fröbert, Ole and Andersson, Jonas and Skoglund, Christofer and Ponten, Johan and Björklund, Fredrik and Kastberg, Robert and Ljungman, Charlotta and Bolin, Kristian and Redfors, Björn}, year = {2025}, journal = {American Heart Journal}, volume = {290}, pages = {158--160}, doi = {10.1016/j.ahj.2025.07.006}, url = {1983506}, language = {eng}, publisher = {Elsevier}, issn = {0002-8703} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_moultriefiona_2025, title = {Analgesia and sedation in premature infants receiving invasive ventilation : a systematic scoping review}, author = {Moultrie, Fiona and Durrmeyer, Xavier and van den Bosch, Gerbrich E. and Tauzin, Manon and Roué, Jean Michel and Olsson, Emma and Cobo, Maria M. and Baxter, Luke and Iyer, Samyuktha and Bhatt, Aomesh and Simons, Sinno H. P. and Slater, Rebeccah}, year = {2025}, journal = {Pediatric Research}, doi = {10.1038/s41390-025-04441-y}, url = {2016159}, language = {eng}, publisher = {Nature Publishing Group}, abstract = {BACKGROUND: Premature neonates often require mechanical ventilation during intensive care. However, there is a lack of clinical consensus on the provision, type, and dosage of analgosedatives. The purpose of this scoping review is to assess the risks and benefits of providing analgesic and sedative drugs to ventilated premature infants.METHODS: We sourced primary empirical research reporting outcomes related to the use of pharmacological analgesics and sedatives in ventilated premature infants. We included articles published in any language in peer-reviewed journals before February 2024 from MEDLINE, Embase, Web of Science, Cochrane Library, and Google Scholar databases. We present the overall study characteristics, and the reported risks and benefits of analgosedatives within drug sub-groups.RESULTS: 80 studies were included in the scoping review. Morphine was the most studied drug (39 studies), followed by fentanyl (19 studies). Midazolam (8 studies) and dexmedetomidine (3 studies) were the most frequently studied sedatives. Analgesic efficacy was more consistently reported for fentanyl than morphine. The sedative effect of opioids was rarely assessed. Respiratory, cardiovascular, gastrointestinal, neurological and neurodevelopmental risks were unclear for all opioids. Alternative synthetic opioids and midazolam appear to be associated with significant risks in the absence of clear benefits. Dexmedetomidine shows encouraging but limited results and merits further investigation as an opioid-sparing adjunct.CONCLUSION: At present, fentanyl appears to have the best efficacy and safety profile for analgosedation in this patient population. This scoping review will support clinicians in their analgosedative management of ventilated premature infants and identifies research gaps and priorities.IMPACT: This systematic scoping review provides a comprehensive summary of the evidence of the risks and benefits of analgesics and sedatives in ventilated premature infants. Although morphine is the most extensively studied and used drug, its analgesic effect has been less consistently reported than that of fentanyl. Sedation has rarely been assessed and dexmedetomidine seems a promising sedative adjunct as midazolam use is not supported by evidence.}, issn = {0031-3998} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_tseronisassimakis_2025, title = {Analysing multimodal argumentation : Theoretical and methodological considerations}, author = {Tseronis, Assimakis}, year = {2025}, pages = {147--164}, doi = {10.4324/9781003502296-9}, url = {2018966}, language = {eng}, publisher = {Routledge}, keywords = {multimodal argumentation; argument reconstruction; argument evaluation; environmental communication}, abstract = {The chapter advocates for a multimodal understanding of argumentative communication, recognizing that verbal, visual and other semiotic modes all contribute to the expression of the core elements of the argument and to the understanding of the reasoning that connects them. It explores theoretical and methodological considerations related to three core questions that are common to the various approaches to the study of multimodal argumentation: the identification of arguments in multimodal communication, their reconstruction, and their evaluation. By discussing existing proposals and presenting analyses of examples of pictographs, photographs, and advertisements concerning plastic pollution, the chapter demonstrates how systematic attention to the semiotic properties of argumentative texts and their situational and institutional context enhances the interpretation and reconstruction as well as evaluation of multimodal argumentation, thereby improving the depth and quality of the argumentative analysis of communication.}, file = {https://oru.diva-portal.org/smash/get/diva2:2018966/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindholmlars_2025, title = {Analysis of Cost and Treatment Effects in the Care Given for Graves' Disease : A Swedish Cost-Utility Analysis}, author = {Lindholm, Lars and Sjölin, Gabriel and Jonsson, Annika and Abraham-Nordling, Mirna and Wallin, Göran and Nyström, Helena Filipsson}, year = {2025}, journal = {Endocrinology, Diabetes & Metabolism}, volume = {8}, number = {2}, doi = {10.1002/edm2.70034}, url = {1944007}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {cost-effectiveness analysis; graves' disease; health economics; icer; qaly}, abstract = {Background: Guidelines in healthcare should be evidence-based, satisfy patient needs and improve patient outcome.Methods: We performed a cost-utility analysis in Graves' disease (GD) and estimated incremental costs after the introduction of a national guideline adding the Graves' Recurrent Events After Therapy (GREAT) score with genetic determinants (GREAT+) to predict recurrence, a thyroid nurse, preoperative calcium/vitamin D treatment and thyroid-stimulating immunoglobulins.Findings: Antithyroid drugs (ATDs) were less costly, achieved 0.88 quality-adjusted life years (QALYs) over 8 years and dominated over radioactive iodine (RAI) treatment. The relevant incremental cost-effectiveness ratio was ATD versus thyroid surgery (Tx). Tx was more costly than ATD but was also more effective. The incremental cost-effectiveness ratio was equal to 40,488 Euro per QALY gained. In recurrent GD, the QALY weight for surgery after ATD was 0.76 compared with 0.79 when surgery was the initial treatment. If individuals requiring surgery could be identified at start of first treatment, QALYs would be higher (6.32) and the cost lower (13,945 Euro). The net cost increase after the new guideline was 17.6%, which was partially an effect from more time being spent with the thyroid nurse. If the GREAT+ score was also applied, the total increased net cost was 14.8% if 24% of the tested patients changed treatment to Tx.Interpretation: Tx was more cost-effective than RAI when ablative treatment is advocated. Prediction score for recurrence directing patients to earlier Tx is cost-effective and enables the introduction of a specialist thyroid nurse. Health economic evaluations should accompany future guidelines.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gustafssonjohanna_2025, title = {Analysis of factors influencing satisfaction with vocational rehabilitation services for young persons with disabilities in Sweden}, author = {Gustafsson, Johanna and Witte, Ingrid}, year = {2025}, journal = {Frontiers in Rehabilitation Sciences}, volume = {6}, doi = {10.3389/fresc.2025.1573753}, url = {1967086}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {vocational rehabilitation; service user satisfaction; supported employment; case management; person-centered rehabilitation; disability}, abstract = {Purpose: The purpose of this study is to identify what factors influence user satisfaction with vocational rehabilitation services among service users in a Swedish context.Methods: In a randomized control trial, ordinal logistic regression was applied to a dataset of 631 completed questionnaires about the support provided in three different vocational rehabilitation programmes in Sweden—Supported Employment, Case Management and Regular Vocational Rehabilitation.Results: The factors Person-centeredness, Trust in Support Persons, and Experience that the activities help with getting a job were significant factors of satisfaction among service users. The ordinal logistic regression model explained between 34.3% and 49.9% of the variance in the material, depending on the pseudo R2-measure used.Conclusions: Service users who experience vocational support as person-centered, experienced trust in their support persons and that vocational rehabilitation activities help with getting a job are more satisfied with the vocational rehabilitation services than are other service users, independent of the vocational rehabilitation models used. Therefore, a person-centered approach is relevant to include in models’ development and service design of vocational rehabilitation.}, file = {https://oru.diva-portal.org/smash/get/diva2:1967086/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_asifmuhammad_2025, title = {Analysis of parameters of the exponentiated inverse Rayleigh distribution under the Bayesian framework}, author = {Asif, Muhammad and Raftab, Mariya and Usman, Muhammad and Khan, Akbar Ali}, year = {2025}, journal = {Kuwait Journal of Science}, volume = {52}, number = {3}, doi = {10.1016/j.kjs.2025.100424}, url = {1958427}, language = {eng}, publisher = {Elsevier}, keywords = {exponentiated inverse rayleigh distribution; bayesian inference; predictive inference; simulation study}, abstract = {Estimating the unknown parameter(s) of distribution using Bayesian framework is a core topic in statistical literature. This study focuses on the Bayesian estimation and prior selection for the scale and shape parameters of the exponentiated inverse Rayleigh distribution. We consider both informative (chi-square, inverse Le<acute accent>vy) and non-informative (uniform, Jeffreys) priors to update the current state of knowledge regarding the unknown parameters. The squared error loss function (SELF), LINEX loss function (LLF), precautionary loss function (PLF), and quasi-quadratic loss function (QQLF) are employed to demonstrate the effectiveness of priors while estimating the parameters. Expressions for posterior distributions, Bayes estimators (BE), Bayes posterior risks (BPR), credible intervals, and predictive intervals are derived under the aforementioned conditions. Extensive simulation as well as real data analysis is carried out to show the relative performances of the priors and loss functions by comparing the respective BPRs. The results reveal that the inverse Le<acute accent>vy prior outperforms the other priors in terms of minimum BPR and providing tighter credible and predictive intervals while estimating the scale parameter. Whereas, for the shape parameter, the gamma prior shows superior performance. The real data analysis cements the findings of the simulation study.}, issn = {2307-4108} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nowakj_2025, title = {Analysis of the circulating methylome in 155 IBD-discordant twin pairs from UK and Scandinavia highlights differential variance and association with active inflammation}, author = {Nowak, J. and Noble, A. and Gordon, H. and Harbord, M. and Blad, W. and Bergemalm, Daniel and Møller, F. Trier and Ahmad, T. and Andersen, V and Halfvarson, Jonas and Satsangi, J.}, year = {2025}, journal = {Journal of Crohn's & Colitis}, volume = {19}, number = {Suppl. 1}, pages = {i319--i320}, doi = {10.1093/ecco-jcc/jjae190.0169}, url = {1938310}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background: Consistent alterations in DNA methylation across the genome have been well-characterised in inception cohorts of North European patients with inflammatory bowel disease [1-3]; these data implicate inherited determinants, active inflammation and the exposome in shaping the methylome. We have recruited a unique group of 155 twin pairs discordant for IBD to allow exploration of the interplay between these factors.Methods: Whole blood from twins discordant for diagnosis of IBD was profiled using methylation microarrays (Figure) in two cohorts (UK-1 & Scandinavia-2). We performed analysis of both cohorts with epigenome-wide association study (EWAS), investigation of methylation Shannon’s entropy, methylation variance, and the epigenetic age. Analysis of the methylation correlates of disease activity in cohort 1 (UK) was performed. Additionally, smoking-related methylation was explored.Results: The discovery cohort (UK-1) included 64 di- and monozygotic twin pairs while the replication cohort (Scandinavia-2) included 91 sex-matched IBD-discordant twin pairs. The mean age in both cohorts was 53 years and the mean disease duration was 24 years. IBD-discordant twin pairs differed in Shannon’s entropy at individual probes (located in/near IL10RA, IL2RA, IL18RAP, VMP1, CEP72/AHRR), of which three replicated (cg11498228-ARHGEF10, cg07664915-KCTD13/MAPK3, cg20859708-NAA35), and many were located in IBD GWAS regions (such as FOXP1, LPP, MICA). The entropy findings from IBD GWAS regions were partially confirmed in monozygotic twins alone (e.g., TNXB in MHC class III region, bootstrap p.fdr<10-118), despite near-perfect controlling for genetics and early-life exposome. Sites highlighted by differential variance analysis included IBD genes, such as TAS1R3, GALNT2 and CACNA1H (all q-values<5×10-6). No epigenetic age acceleration was identified in patients with IBD. Clinical activity of IBD exhibited a number of associations with the whole blood methylome, including a negative correlation between methylation at a key IBD site RPS6KA2 with faecal calprotectin (Table). In patients with IBD and controls, cross-cohort smoking EWAS replicated multiple smoking-related sites at genome-wide significance, many of which located in AHRR and ALPI loci, both of which are implicated in IBD.Conclusion: Methylation level at individual probes related to IBD activity and showed IBD-associated differences in methylation entropy and variance between twins despite shared genetics and early-life exposome, adding new context for understanding established IBD loci and strengthening their role.References:1. Ventham et al. Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease. Nat Commun. 2016;7:13507.2. Kalla et al. Analysis of Systemic Epigenetic Alterations in Inflammatory Bowel Disease: Defining Geographical, Genetic and Immune-Inflammatory influences on the Circulating Methylome. J Crohns Colitis. 2023;17(2):170-184.3. Ventham et al. Genome-Wide Methylation Profiling in 229 Patients With Crohn's Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn's Disease (TOPPIC). Cell Mol Gastroenterol Hepatol. 2023;16(3):431-450.}, issn = {1873-9946} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hennesseyjohn_2025, title = {Analytic, Comparative, and Historicist Definitions of "Colony"}, author = {Hennessey, John}, year = {2025}, journal = {The Ideology and Politics Journal}, volume = {2}, number = {28}, pages = {9--22}, doi = {10.36169/2227-6068.2025.02.00001}, url = {2024523}, language = {eng}, publisher = {Foundation for Good Politics}, keywords = {colonialism; historical terminology; conceptual history; comparative history; historicism}, abstract = {In an era in which accusations of “colonialism” are increasingly thrown around in political debate, it becomes necessary to define exactly what is meant by “colony.” As this article demonstrates, the heterogeneity and complexity of historical examples make it unexpectedly difficult to pin down exactly what this central term means and which historical territories should be described as “colonies.” The article considers three approaches to defining this key term: analytical, comparative, and historicist. While each has strengths and weaknesses, a case is made for greater historicist research in the future, as this approach is far less developed than the others.}, issn = {2227-6068}, file = {https://oru.diva-portal.org/smash/get/diva2:2024523/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sandngustav_2025, title = {Anastomotic protection at a cost : the renal toll of defunctioning ileostomies in rectal cancer surgery}, author = {Sandén, Gustav and Myrberg, Ida Hed and Boman, Sol Erika and Nordenvall, Caroline and Carrero, Juan-Jesus and Matthiessen, Peter and Rutegård, Martin}, year = {2025}, journal = {British Journal of Surgery}, volume = {112}, number = {Suppl. 11}, pages = {xi15--xi15}, doi = {10.1093/bjs/znaf149.054}, url = {1992011}, language = {eng}, publisher = {Oxford University Press}, abstract = {Introduction: A defunctioning ileostomy lowers the risk of anastomotic leakage after anterior resection for rectal cancer, but may cause kidney injury. This study investigated short- and long-term kidney injuries in patients undergoing low anterior resection, comparing those with and without a stoma.Method: All rectal cancer patients with tumors ≤12 centimetres from the anal verge, operated in Sweden 2007–2021, were identified through the Colorectal Cancer Database Sweden. The primary outcome was end-stage kidney disease, defined as kidney transplantation or maintenance dialysis initiation. Secondary outcomes included chronic kidney disease, acute kidney injury, and dehydration. The impact of stoma reversal and potential mediation effects through anastomotic leakage were also examined. Cox regression was used, weighted by propensity scores based on clinical and socioeconomic predictors for receiving a defunctioning ileostomy.Result: Some 5,291 patients remained after exclusions; 4,625 (87%) received a defunctioning ileostomy and 666 (13%) did not. Stoma placement was not significantly associated with end-stage kidney disease (HR 1.69, 95% CI: 0.19–15.23) or chronic kidney disease (HR 1.65, 95% CI: 0.91–3.00), but was associated with acute kidney injury (HR 3.03, 95% CI: 1.62–5.68) and dehydration (HR 4.02, 95% CI: 2.33–6.95). Risks of chronic kidney disease, acute kidney injury, and dehydration declined following stoma reversal. Stomas reduced anastomotic leakage with a minor attenuating mediation effect on acute kidney injury.Discussion: Long-term kidney damage from ileostomy placement during low anterior resection for rectal cancer was not observed. However, short-term effects were demonstrated. Stoma reversal appeared to have an alleviating effect, suggesting its potential role in mitigating kidney damage.}, issn = {0007-1323} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_isacssonalexander_2025, title = {Anekdotisk historia : Anekdotens föränderliga roll i 1700- och 1800-talens svenska medielandskap}, author = {Isacsson, Alexander}, year = {2025}, journal = {RIG: Kulturhistorisk tidskrift}, number = {3}, pages = {145--164}, url = {2007776}, language = {swe}, publisher = {Kungl. Gustav Adolfs Akademien för svensk folkkultur}, issn = {0035-5267} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssonmimmi_2025, title = {Anemia in patients ten years after bariatric surgery}, author = {Karlsson, Mimmi and Ottosson, Johan and Clarkson, Spencer and Sjöberg, Klas}, year = {2025}, journal = {International Journal of Obesity}, volume = {49}, number = {4}, pages = {612--618}, doi = {10.1038/s41366-024-01675-4}, url = {1913235}, language = {eng}, publisher = {Nature Publishing Group}, abstract = {BACKGROUND: More than 10% of the global population has a BMI above 35. Bariatric surgery is an efficient way to treat this condition. Unfortunately, there is a risk of nutritional deficiencies. The number of studies after a longer time span is scarce. The aim of this study was to determine the occurrence of anaemia five and ten years after bariatric surgery and how it was related to substitution therapy.PATIENTS AND METHODS: Registry data from individuals having primary bariatric surgery in the Scandinavian Obesity Surgery Registry (SOReg) from 2007 to 2022 and with a follow-up at five or ten years was retrieved. Demographic data including weight, as well as method of surgery, Hb levels, supplementation, PPI use and stomal ulcerations were recorded.RESULTS: In total, 39,992 individuals (mean age 41 years, range 18-74, 77% women) could be included. The majority, 78%, had undergone laparoscopic Roux-en-Y gastric bypass. After five years, 2838/13,944 women (20.3%) and 456/4049 men (11.2%) had anaemia. After ten years, 644/3400 women (18.9%) and 178/947 men (18.8%) had anaemia. The use of oral iron increased from 40 to 45%, and the need for parenteral iron intake increased from 5 to 11%.CONCLUSIONS: Anaemia is a significant but manageable condition five and ten years after bariatric surgery. Despite the prescription of oral iron supplements to 45% ten years after surgery, the Hb levels could still not be fully restored. Consequently, the importance of follow-up visits and continuous supplementation is emphasised.}, issn = {0307-0565} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_welnschefkerstin_2025, title = {Angina Pectoris Prevalence and Sick Leave Burden 1 Year After Myocardial Infarction With Nonobstructive Coronary Arteries}, author = {Welén Schef, Kerstin and Tornvall, Per and Lindahl, Bertil and Nordenskjöld, Anna M. and Jernberg, Tomas}, year = {2025}, journal = {Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease}, volume = {14}, number = {14}, doi = {10.1161/JAHA.124.037264}, url = {1988556}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {angina; minoca}, abstract = {BACKGROUND: Symptom burden and disease effects following myocardial infarction with nonobstructive coronary arteries (MINOCA) are not well studied. We aimed to evaluate the prevalence of angina pectoris, sick leave, and quality-of-life levels 1 year after the index event, using patients with myocardial infarction due to obstructive coronary artery disease (MI-CAD) as controls.METHODS AND RESULTS: Patients with first-time myocardial infarction, assessed by coronary angiography and registered in the SWEDEHEART (Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies) registry 2005 to 2022 were eligible and included if attending the 1-year follow-up. Patients with previous coronary intervention, heart failure, arrhythmia at admission, and not fully revascularized MI-CAD were excluded. Outcomes were prospectively collected during standard care. A total of 46 428 patients (mean age, 62years; 71% men; MINOCA, n=5281/MI-CAD, n=41 157) were assessed after 1 year. Angina prevalence was 11.6% in MINOCA and 8.8% in fully revascularized MI-CAD (crude risk ratio, 1.32 [95% CI, 1.21-1.47]; odds ratio, 1.18 [95% CI, 1.07-1.30], adjusted for potential confounders). Patients with MINOCA had a higher degree of sick leave than patients with MI-CAD both at index care and at 1 year (8.0% versus 5.6% and 13.4% versus 10.9%, respectively; both P<0.001). Quality-of-life measures were lower in MINOCA. These associations were unaffected when adjusting for angina status but were attenuated when adjusting for potential confounders.CONCLUSIONS: Patients with MINOCA have significant distress, with higher levels of angina pectoris and sick leave and worse quality of life at 1 year compared with fully revascularized MI-CAD counterparts.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_holmsebastian_2025, title = {Ankle instability and gait disturbance after free fibula flap reconstruction in head and neck cancer reconstruction : A systematic review}, author = {Holm, Sebastian and Löfgren, Jenny and Landström, Fredrik and Ali, Rodi and Tabrisi, Reza and Wyckman, Alexander and Bazsefidpay, Nikoo and Zdolsek, Johann and Berner, Juan Enrique}, year = {2025}, journal = {JPRAS Open}, volume = {46}, pages = {33--49}, doi = {10.1016/j.jpra.2025.08.005}, url = {1995604}, language = {eng}, publisher = {Elsevier}, keywords = {ankle instability; complications; donor site morbidity; gait disturbance; head and neck reconstruction; microsurgery}, abstract = {INTRODUCTION: The free fibula flap is a workhorse flap for bony reconstruction of the craniofacial skeleton. The aim of the study was to conduct a systematic review to investigate the postoperative donor site complications and functional outcomes, specifically ankle instability (AI) and gait disturbances (GD), for patients who have received a free fibula flap (FFF) for head and neck cancer reconstruction.METHODS: We designed a PRISMA-compliant systematic review, which was registered prospectively in PROSPERO. Searches were designed with a health science librarian and included MEDLINE, EMBASE, CINAHL and PEDro. Risk of bias assessment was conducted for each included study, with an assessment of quality using GRADE.RESULTS: Following exclusion of duplicate entries, a total of 1940 abstracts were identified. After parallel blinded eligibility assessment, 32 studies were included in the analysis. The total number of included participants was 1163, with the total number of FFF being 955. The mean time for functional assessment was 35 months postoperatively (range 8-81 months). The subjective and objective assessment modalities varied considerably. The primary result for AI were 3.3 % and 5.5 % for GD. The results demonstrate heterogeneity in the literature regarding the reporting of AI and GD following FFF.CONCLUSION: According to this review, the risk of developing these complications appears to be limited but underreporting may be a limitation. Consensus on methods for standardized outcomes assessment of FFF-reconstruction is needed to establish the impact of free fibula flap on AS and GD.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_gunnarssonlena_2025, title = {Anna G. Jónasdóttir}, author = {Gunnarsson, Lena}, year = {2025}, pages = {227--237}, url = {2009952}, language = {swe}, publisher = {Daidalos}, keywords = {anna g. jónasdóttir; kärlekskraft; marxistisk teori; historiematerialism; kärlek; sexualitet; feministisk teori; marxistisk feminism; socialistisk feminism; social reproduktion}, abstract = {Den Sverigebaserade historiematerialistiska feministiska teoretikern Anna G. Jónasdóttir är mest känd för sitt begrepp kärlekskraft, som hon ser som en grundläggande, exploaterbar mänsklig kapacitet jämförbar med men distinkt från arbetskraft. Kärlek, menar Jónasdóttir, är en produktiv, livgivande kraft och praktik med både omsorgsmässiga och erotiska komponenter, som behöver tas på teoretiskt allvar som oreducerbar faktor av historisk betydelse. Utifrån en unik läsning av de historiematerialistiska premisserna och en respekt för radikalfeministiska frågeställningar argumenterar Jónasdóttir för att den könsdistinkta materiella basen för kvinnors underordning i formellt jämställda patriarkat står att finna i mäns exploatering av kvinnors kärlek.Kapitlet introducerar Jónasdóttirs bidrag med fokus på två teman som behandlas i hennes senare arbeten (2009–2023). Först redogör jag för hennes tolkning av Marx och Engels skrivningar om historiematerialismens grundläggande premisser och visar hur den underbygger en analys av kön och makt som skiljer sig från marxianska feministiska analyser fokuserade på omsorg och arbete. Därnäst visar jag på den ökade relevansen av Jónasdóttirs analys av kärlek inom ett marxistiskt ramverk. Huvudargumentet här är att människors förmåga till och behov av kärlek (i bred bemärkelse) får en alltmer framträdande roll som exploaterbar – och därmed revolutionärt betydelsefull – mänsklig kapacitet, i och med kapitalismens och patriarkatets utvecklingstendenser.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_linnagneta_2025, title = {Anna Sörensen : Rektor och föregångare}, author = {Linné, Agneta}, year = {2025}, pages = {159--179}, url = {2012467}, language = {swe}, publisher = {Gidlunds förlag} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gabrielelhajjvictor_2025, title = {Answer to the letter to the editor of J. Tu, et al. concerning "Patient-reported outcome measures and satisfaction after laminectomy for degenerative cervical myelopathy in octogenarians : an observational study from the National Swedish spine registry" by V.G. El-Hajj, et al. (Eur spine J [2025]; doi: 10.1007/s00586-025-08890-1)}, author = {Gabriel El-Hajj, Victor and Staartjes, Victor E. and Charalampidis, Anastasios and Nilsson, Gunnar and Gerdhem, Paul and Edström, Erik and Elmi-Terander, Adrian and Åkerstedt, Josefin}, year = {2025}, journal = {European spine journal}, volume = {34}, number = {11}, pages = {5368--5369}, doi = {10.1007/s00586-025-09259-0}, url = {1998527}, language = {eng}, publisher = {Springer}, issn = {0940-6719} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fengsrudespen_2025, title = {Antiarrhythmic drug use in atrial fibrillation among different European countries - as determined by a physician survey}, author = {Fengsrud, Espen and Blomström-Lundqvist, Carina and Camm, A. John and Goette, Andreas and Kowey, Peter R. and Merino, Jose L. and Piccini, Jonathan P. and Saksena, Sanjeev and Reiffel, James A. and Boriani, Giuseppe}, year = {2025}, journal = {IJC Heart & Vasculature}, volume = {59}, doi = {10.1016/j.ijcha.2025.101709}, url = {1970029}, language = {eng}, publisher = {Elsevier}, keywords = {atrial fibrillation; antiarrhythmic drug; physician; survey; guidelines}, abstract = {Background: There is limited knowledge of physicians' antiarrhythmic drug (AAD) treatment practices for patients with atrial fibrillation and adherence to guidelines in European countries.Methods: An online survey (n = 321) of cardiologists, cardiac electrophysiologists and interventional electrophysiologists was conducted in Germany (DE; n = 83), Italy (IT; n = 95), Sweden (SE; n = 60) and the United Kingdom (UK; n = 83) including 96 questions on treatment practices.Results: ESC guidelines were the most important non-patient factor influencing treatment practice (55-72 %). However, while amiodarone was frequently (88-93 %) used in heart failure with reduced left ventricular ejection fraction, it was also a typical treatment choice for minimal/no-structural heart disease (SHD) (28 %), particularly in UK. Other deviations from guidelines were the use of class 1C drugs in coronary artery disease (CAD) and other SHD, and use of sotalol in left ventricular hypertrophy and renal impairment. In-hospital initiation of sotalol was low, with the exception of SE. Sotalol (16-41 %) and dronedarone use (10-54 %) in CAD varied among countries. For frequent, symptomatic paroxysmal AF, ablation was generally favoured, but AADs were preferred by 53 % in SE. In asymptomatic or subclinical AF, AADs were used by 41 % (range: 22-60 %), ablation by 11 % (range 2-18 %). In contrast to guidelines that prioritize safety, anticipated efficacy was more important (51 %) than safety (31 %) when selecting AADs.Conclusions: Despite recognizing the importance of guidelines, deviations in AAD use were common with the potential to compromise patient safety. These findings indicate the need for more educational support for optimal AAD selection in AF management.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wnstrmjohane_2025, title = {Antibiotic prophylaxis and incidence of infection following elbow arthroplasty : a nationwide study}, author = {Wänström, Johan E. and Dettmer, Anne and Björnsson Hallgren, Hanna C. and Salomonsson, Björn and Ljungquist, Oskar and Adolfsson, Lars}, year = {2025}, journal = {Acta Orthopaedica}, volume = {96}, pages = {278--282}, doi = {10.2340/17453674.2025.43288}, url = {1947956}, language = {eng}, publisher = {Taylor & Francis}, abstract = {BACKGROUND AND PURPOSE: Periprosthetic joint infection (PJI) after elbow arthroplasty is a serious complication. Evidence of the best antibiotic prophylaxis for elbow arthroplasty is lacking. We aimed to investigate the regimens presently used in Sweden, incidence of PJI, and the bacteria most frequently found in elbow PJI.METHODS: A questionnaire was sent out to all Swedish units performing elbow arthroplasty in 2019 asking about antibiotic prophylaxis routines. The Swedish Elbow Arthroplasty Register (SEAR) and national inpatient and outpatient registers (NPR) from the National Board of Health and Welfare were searched for procedures related to all primary total- or hemi-elbow arthroplasties performed during 2019-2021. Results of microbiological analyses of the suspected PJI cases were collected from the respective laboratory.RESULTS: Most centers used only cloxacillin (44%) or cloxacillin together with benzylpenicillin (44%), as prophylaxis. 250 primary procedures were performed between 2019 and 2021, and the most used antibiotic prophylaxes were cloxacillin (61%) and cloxacillin with benzylpenicillin (23%). In the NPR, 20 patients (8%) with a diagnosis that could indicate PJI were found and 9 (3.6%) had a confirmed PJI. The most common bacteria were Staphylococcus epidermidis, Cutibacterium acnes, and Staphylococcus aureus.CONCLUSION: Most centers used cloxacillin antibiotic prophylaxis for elbow arthroplasty. The incidence of PJI was 3.6%. The most frequent diagnosed pathogen was Staphylococcus epidermidis.}, issn = {1745-3674} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_edslevsofiem_2025, title = {Antibiotic resistance and population structure of Staphylococcus epidermidis from prosthetic joint infections in Sweden and France}, author = {Edslev, Sofie M. and Laurent, Frederic and Månsson, Emeli and Johannesen, Thor Bech and Aarris, Mia and Sönksen, Ute Wolff and Kolenda, Camille and Söderquist, Bo and Stegger, Marc}, year = {2025}, journal = {Journal of Antimicrobial Chemotherapy}, volume = {80}, number = {7}, pages = {2007--2015}, doi = {10.1093/jac/dkaf166}, url = {1967240}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background and objectives: Staphylococcus epidermidis is a major cause of prosthetic joint infections (PJIs). Multidrug resistant (MDR), hospital-adapted clones constitute most cases globally, though regional differences in lineage dissemination likely exist. The aim was to explore the population structure of S. epidermidis from PJIs in Sweden and France, with a focus on the presence of antimicrobial resistance (AMR).Methods: This study included genome sequence data from 191 clinical S. epidermidis isolates collected from patients with PJI in central Sweden (2007-16; n = 138) and the Lyon region in France (2015-20; n = 53).Results: Hospital-adapted lineages with a high burden of AMR dominated the cases in both countries. However, the ST2 lineage was significantly more prevalent in Sweden (43% versus 11% in France), while ST5 and ST87 were more common in France (55% versus 10% in Sweden). ST215 was only present in Sweden (25%). A significantly higher prevalence of streptogramin resistance genes [vat(B), vga(A), vga(B)] was found in French (26%) versus Swedish (2%) isolates. These genes were present in all ST87 isolates and in 20% of the French ST5 isolates. The erm(C) gene (resistance to streptogramin A, macrolides and lincosamides) was also more common in the French isolates (77% versus 55% of Swedish isolates), and so was the fusidic acid resistance gene fusB (France: 66%, Sweden: 39%).Conclusions: This study highlights significant regional differences in S. epidermidis variants causing PJI. Despite similar MDR levels, certain AMR genes, particularly those related to streptogramin resistance, were significantly more prevalent among French isolates. This suggests that S. epidermidis undergoes local adaptation to region-specific antibiotic usage.}, issn = {0305-7453} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_uggehenrik_2025, title = {Anti-Inflammatory Diet Index (AIDI) and bladder cancer risk : a 22-Year Prospective Swedish cohort study (1998-2020)}, author = {Ugge, Henrik and Fall, Katja and Taj, Tahir}, year = {2025}, journal = {European Urology}, volume = {87}, number = {Suppl. 1}, url = {2008044}, language = {eng}, publisher = {Elsevier}, abstract = {Introduction & Objectives: Tobacco smoking and occupational exposure to carcinogens constitute well-established risk factors for bladder cancer (BC), while limited evidence suggest a possible effect of dietary factors and inflammation on BC risk. Dietary patterns with impact on systemic levels of inflammation have further been proposed and investigated as possible determinants of cancer risk. In this cohort study, we evaluated the association between the anti-inflammatory potential of diet and the risk of BC.Materials & Methods: Using the Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research (SIMPLER), we identified a study population of N=79,292 men and women derived from the two original cohorts Cohort of Swedish Men (COSM, established in 1997) and Swedish Mammography Cohort (SMC, established in 1987). We used a 96-item food frequency questionnaire (FFQ), completed at baseline in 1997 and repeated in 2009, to calculate the Anti-Inflammatory Diet Index (AIDI) for all participants. AIDI is a previously developed, empirically derived composite measure of dietary anti-inflammatory potential, based on the food groups previously found to have the strongest association with levels of systemic inflammation. The index comprises 16 food groups: 11 with proposed anti-inflammatory and 5 with proposed pro-inflammatory potential. We used ICD-10 code C67 to identify incident BC cases op to year 2020 in the Swedish National Cancer Register, and we used baseline study questionnaire to assess covariates, including smoking status and socioeconomic measures. We further used Cox proportional hazards regression models to estimate unadjusted and multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the association between quartiles of AIDI in the population and later BC diagnosis – overall as well as with outcome separated into non-muscle invasive (NMIBC: Ta or T1 or CIS and N0, M0) and muscle invasive (MIBC: ≤T2 or N1 or M1) BC for cases occurring after year 2004.Results: During follow-up until 2020, 1165 BC cases occurred, of which 249 were non-muscle invasive, 201 muscle invasive and 715 of unknown stage. Overall, we observed an inverse association between the highest quartile of AIDI (Q4 vs. Q1, representing most anti-inflammatory diet compared to most pro-inflammatory) and later BC diagnosis (multivariable-adjusted HR 0.74, 95% CI 0.61-0.89, p-trend: 0.01). When separating outcome by stage, we observed an association for MIBC (HR 0.35, 95% CI 0.22-0.57), but not for NMIBC (HR 0.86, 95% CI 0.57-1.28).Conclusions: We observed an inverse association between a measure of dietary anti-inflammatory potential and BC risk, particularly the risk of MIBC. Our observations support a possible implication of the inflammatory potential of diet in BC development and the more pronounced association observed for MIBC may hint at a true biological association.}, issn = {0302-2838} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tajtahir_2025, title = {Anti-Inflammatory Diet Index and risk of renal cell carcinoma}, author = {Taj, Tahir and Sundqvist, Pernilla and Wolk, Alicja and Fall, Katja and Ugge, Henrik}, year = {2025}, journal = {British Journal of Cancer}, volume = {132}, number = {11}, pages = {1027--1039}, doi = {10.1038/s41416-025-03000-w}, url = {1950237}, language = {eng}, publisher = {Nature Publishing Group}, abstract = {INTRODUCTION: A diet rich in fruits, vegetables, coffee, and tea, limited red meat, and moderate alcohol intake may reduce the risk of renal cell carcinoma (RCC). The anti-inflammatory potential of diet has been proposed as a mechanism influencing cancer risk. This study assessed the association between an anti-inflammatory diet and RCC risk.METHODOLOGY: Data from two Swedish cohorts, the Swedish-Mammography-Cohort and the Cohort-of-Swedish-Men, were analysed. Dietary habits were assessed using a 96-item food frequency questionnaire. The Anti-Inflammatory Diet Index (AIDI), composed of 16 food groups (11 anti-inflammatory and 5 pro-inflammatory), was used to score dietary patterns. RCC cases were identified from the Swedish Cancer Register using ICD-10 codes, and Cox proportional hazards models were used to estimate hazard ratios based on AIDI quartiles.RESULTS: Among 71,421 participants, 431 RCC cases were identified during a 19.7-year follow-up. Higher AIDI scores were associated with a lower RCC risk (HR for Q4 vs. Q1: 0.68, CI: 0.52-0.89). In sex-stratified analyses (p-for heterogeneity = 0.006), the association was stronger in among women (HR: 0.47, CI: 0.30-0.75) but less clear in among men (HR: 0.83, CI: 0.63-1.24).CONCLUSION: These data suggest that adherence to an anti-inflammatory diet may confer a reduced risk for RCC, especially among women.}, issn = {0007-0920} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_pertsinidoueleftheria_2025, title = {Anti-integrin αvβ6 IgG antibody as a diagnostic and prognostic marker in ulcerative colitis : A cross-sectional and longitudinal study defining a specific disease phenotype}, author = {Pertsinidou, Eleftheria and Salomon, Benita and Bergemalm, Daniel and Salihovic, Samira and Hedin, Charlotte R. H. and Ling Lundström, Maria and Keita, Åsa V. and Magnusson, Maria K. and Eriksson, Carl and Bengtson, May-Bente and Grännö, Olle and Aabrekk, Tone B. and Movérare, Robert and Rydell, Niclas and Ekoff, Helena and Rönnelid, Johan and D'Amato, Mauro and Detlie, Trond E. and Huppertz-Hauss, Gert and Opheim, Randi and Ricanek, Petr and Kristensen, Vendel A. and Öhman, Lena and Söderholm, Johan D. and Kruse, Robert and Lindqvist, Carl Mårten and Carlson, Marie and Repsilber, Dirk and Høivik, Marte L. and Halfvarson, Jonas}, year = {2025}, journal = {Journal of Crohn's & Colitis}, volume = {19}, number = {5}, doi = {10.1093/ecco-jcc/jjaf062}, url = {1954893}, language = {eng}, publisher = {Oxford University Press}, keywords = {autoantibodies; inflammatory bowel disease; ulcerative colitis}, abstract = {BACKGROUND AND AIMS: The diagnostic and prognostic properties of anti-integrin αvβ6 IgG autoantibodies in ulcerative colitis (UC) are poorly understood. We aimed to assess the diagnostic performance of anti-integrin αvβ6 autoantibodies and examine their association with disease outcomes.METHODS: Serum samples from a Swedish inception cohort of patients with suspected inflammatory bowel disease (IBD, n=473) were analysed using an in-house fluorescence enzyme immunoassay based on EliA™technology. Findings were validated in a Norwegian population-based inception cohort (n=570). Diagnostic performance was assessed by calculating the area under the curve (AUC) with 95% confidence intervals (CIs) and determining sensitivity and specificity. Reclassification was evaluated using the net reclassification index.RESULTS: In the discovery cohort, patients with UC, IBD-unclassified, or colonic Crohn's disease exhibited higher median autoantibody levels compared to symptomatic and healthy controls. In the validation cohort, the autoantibody demonstrated 79% sensitivity and 94% specificity for UC vs symptomatic controls at a cut-off of 400 UA/l. Its diagnostic performance (AUC=0.92, 95%CI 0.89-0.95) was superior to hs-CRP (AUC=0.65, 95%CI 0.60-0.70, P<0.001) and faecal calprotectin (fcalpro) (AUC=0.88, 95%CI 0.84-0.92, P=0.09). Combining the autoantibody with fcalpro further improved diagnostic accuracy (AUC=0.97, 95%CI 0.95-0.98) and patient reclassification (P<0.001). Autoantibody positivity was associated with a severe phenotype of UC, characterised by increased inflammatory activity and higher IL-17A and granzyme B levels. Higher autoantibody levels were linked to an aggressive disease course, remaining stable in aggressive UC but decreasing in indolent disease (P=0.003).CONCLUSIONS: Anti-integrin αvβ6 is a reliable diagnostic and prognostic marker for UC, with potential clinical implementation.}, issn = {1873-9946} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_wimanemanuel_2025, title = {Antimicrobial peptides for topical treatment of bacterial wound infections}, author = {Wiman, Emanuel}, year = {2025}, url = {1961692}, language = {eng}, publisher = {Örebro University}, keywords = {antibiotic resistance; antimicrobial peptides; bacteriocin; plantaricin; lipopeptides; eskape; pathogens; chronic wounds; wound healing}, abstract = {Modern medicine relies on the access to effective antibiotics. They are not only necessary to treat infections but enable the invasive therapies and surgeries to which we are accustomed today. Hence, the significant rise of bacterial resistance towards antibiotics threatens to topple a large part of global health care. This thesis investigates the potential of two antimicrobial peptides (AMPs), namely the bacteriocin Plantaricin NC8 ∝β (PLNC8 ∝β), and a novel synthetic lipopeptide derived from PLNC8 β termed 6-C5-N, for the topical treatment of infected wounds. Through a series of studies, the effectiveness and broad-spectrum activity of both these AMPs in vitro is demonstrated, and their influence on human cells in regard to toxicity, inflammation and survival is evaluated. Both AMPs exhibit low cytotoxicity in vitro and modulate important cytokines and growth factors in relation to infection and wound healing. Furthermore, utilizing ex vivo and in vivo models, it is demonstrated that 6-C5-N is an interesting candidate for the topical treatment of infected wounds. Additionally, a possible explanation of the complex problem with bacterial resistance to AMPs is presented, by demonstrating how extracellular divalent cations can be utilized by gram negative bacteria as protection against positively charged antibacterial peptides. In conclusion, PLNC8 ∝β and its derivative lipopeptide 6-C5-N are promising candidates for topical treatment of infected tissues and could play a role in the struggle against the development of antimicrobial resistance.}, file = {https://oru.diva-portal.org/smash/get/diva2:1961692/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jacobssonsusanne_2025, title = {Antimicrobial resistance in Neisseria gonorrhoeae and its risk groups in 23 European countries in 2022 within the European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) : a retrospective observational study}, author = {Jacobsson, Susanne and Cole, Michelle J. and Schröder, Daniel and van Rensburg, Melissa Jansen and Day, Michaela and Ködmön, Csaba and Unemo, Magnus}, year = {2025}, journal = {The Lancet Regional Health: Europe}, volume = {54}, doi = {10.1016/j.lanepe.2025.101318}, url = {1961604}, language = {eng}, publisher = {Elsevier}, keywords = {gonorrhoea; neisseria gonorrhoeae; treatment; antimicrobial resistance; surveillance; ecdc; europe}, abstract = {Background: Since 2009, the European Centre for Disease Prevention and Control (ECDC) has coordinated the European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) to monitor antimicrobial resistance (AMR) in Neisseria gonorrhoeae across the European Union and European Economic Area (EU/EEA). The aims of this study were to report Euro-GASP 2022 data and to compare with the most recently published Euro-GASP data (from 2016 to 2019), to identify changes in AMR and in risk groups for AMR.Methods: In this observational study, 23 EU/EEA countries submitted AMR data for gonococcal isolates from 2022, linked to patient epidemiological data, to The European Surveillance System (TESSy). Statistical analyses (Z-test) were used to determine the significance of the differences between the epidemiological data and proportion of AMR isolates in 2022 versus 2019 and 2016. The risk factors associated with AMR isolates were assessed using univariate and multivariable logistic regression analyses of odds ratios.Findings: Ceftriaxone resistance in 2022 (0.03%, 1/3008) remained low (0.06% (2/3239) in 2019), and cefixime resistance (0.3%, 10/3008) had decreased (0.8% (26/3239) in 2019). Azithromycin resistance (24.9%, 749/3008) and ciprofloxacin resistance (65.8%, 1980/3008) had increased (9.0% (284/3159) and 57.4% (1665/2884), respectively, in 2019). A marked increase in the number (575; 502 in 2019) and proportion (19.2%; 15.8% in 2019) of female gonorrhoea cases was also identified in 2022. In the univariate analysis, azithromycin resistance was associated with oropharyngeal (OR 1.67, CI 1.28-2.18; p < 0.0001) and anorectal infections (OR 1.38, CI 1.08-1.76; p = 0.0094), men-who-have-sex-with-men (MSM) (OR 3.88, CI 2.80-5.37; p < 0.0001), and females (1.71, CI 1.21-2.41; p = 0.0022). In the multivariable logistic regression model, only azithromycin resistance and MSM remained associated (OR 2.85, CI 1.33-4.73; p = 0.0040).Interpretation: While ceftriaxone resistance remains sporadically detected in Euro-GASP, the increase in reports of occasional ceftriaxone resistance in EU/EEA countries and substantial increase in azithromycin resistance underscore the urgent need for enhanced AMR surveillance. The Euro-GASP data is crucial for refining treatment guidelines and mitigating the spread of AMR gonococcal strains. Novel effective antimicrobials for gonorrhoea treatment remain imperative.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_maatoukismael_2025, title = {Antimicrobial resistance in Neisseria gonorrhoeae in nine sentinel countries within the World Health Organization Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP), 2023 : a retrospective observational study}, author = {Maatouk, Ismael and Vumbugwa, Phiona and Cherdtrakulkiat, Thitima and Heng, Lon Say and Hoffman, Irving and Palaypayon, Noel and Kakooza, Francis and Kittiyaowamarn, Rossaphorn and Kyambadde, Peter and Lahra, Monica M. and Lan, Pham Thi and Maseko, Venessa and Matoga, Mitch and Machiha, Anna and Müller, Etienne and Nguyen, Thuy Thi Phan and Doanh, Le Huu and Ouk, Vichea and Setiawaty, Vivi and Sia, Sonia B. and Hartono, Teguh S. and Virak, Mot and Thuy Van, Nguyen Thi and Unemo, Magnus and Wi, Teodora}, year = {2025}, journal = {The Lancet Regional Health: Western Pacific}, volume = {61}, doi = {10.1016/j.lanwpc.2025.101663}, url = {1996385}, language = {eng}, publisher = {Elsevier}, keywords = {antimicrobial resistance; enhanced gonococcal antimicrobial surveillance programme (egasp); gonorrhoea; neisseria gonorrhoeae; surveillance}, abstract = {BACKGROUND: The global spread of antimicrobial resistance (AMR) in Neisseria gonorrhoeae threatens empiric single-dose gonorrhoea treatment. Enhanced global AMR surveillance is imperative. We report i) gonococcal antimicrobial susceptibility and resistance data from 2023 in the World Health Organization Enhanced Gonococcal Antimicrobial Surveillance Programme (WHO EGASP) in the WHO Western Pacific Region (Cambodia, the Philippines, Viet Nam), Southeast Asian Region (Indonesia, Thailand), and African Region (Malawi, South Africa, Uganda, Zimbabwe), and ii) metadata of the gonorrhoea patients.METHODS: In 2023, WHO EGASP included men with urethral discharge (n = 3498) and gonococcal isolates (n = 2491). Minimum inhibitory concentrations (MICs, mg/L) values were determined for ceftriaxone, cefixime, azithromycin, gentamicin, and ciprofloxacin using Etest (bioMérieux). Breakpoints from the European Committee on Antimicrobial Susceptibility Testing (EUCAST) were applied. Clinical and epidemiological variables associated with AMR isolates were assessed using univariable and multivariable logistic regression analyses of odds ratios.FINDINGS: Overall, 3.8% (95% confidence interval (95% CI) 3.1-4.6%; 95/2487), 8.9% (95% CI 7.9-10.1%; 222/2484), 3.6% (95% CI 2.9-4.4%; 89/2487), and 95.3% (95% CI 93.2-97.5%; 1801/1890) of isolates were resistant to ceftriaxone, cefixime, azithromycin, and ciprofloxacin, respectively. All the ceftriaxone-resistant isolates were from Cambodia (15.3% (95% CI 11.5-20.1%), 42/274) and Viet Nam (20.4% (95% CI 15.9-25.7%), 53/260). In univariable analysis, ceftriaxone resistance was associated with travelling within the country during previous 30 days (OR 4.66, 95% CI 3.06-7.16; p < 0.001), and this association remained in multivariable analysis (aOR 4.12, 95% CI 2.65-6.65; p < 0.001).INTERPRETATION: Resistance to ceftriaxone, cefixime, and azithromycin is a major global concern, and expanded and improved resistance surveillance is essential. The WHO EGASP has been substantially expanded in the recent years. Additionally, resistance breakpoints have been harmonised and test-of-cure, whole-genome sequencing, and extragenital sampling implemented, where feasible. Novel antimicrobials for gonorrhoea treatment are critical; zoliflodacin and gepotidacin are promising.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jedlinaluiza_2025, title = {Antithrombotic but not anticoagulant activity of the thrombin-binding RNA aptamer Apta-1}, author = {Jedlina, Luiza and Paramel Varghese, Geena and Soboleva, Svetlana and Chutna Olin, Oldriska and Haug, Marianne and Fransén, Karin and Lindstam, Mikael and Brewinska-Olchowik, Marta and Piwocka, Katarzyna and Grenegård, Magnus}, year = {2025}, journal = {British Journal of Pharmacology}, volume = {182}, number = {6}, pages = {1358--1376}, doi = {10.1111/bph.17382}, url = {1920387}, language = {eng}, publisher = {Macmillan Publishers Ltd.}, keywords = {apta‐1; par1; par4; rna aptamer; antithrombotic; aptamer; thrombin}, abstract = {BACKGROUND AND PURPOSE: Pharmacological intervention of thrombosis is challenging, requiring a fined tune balance between beneficial antithrombotic effect versus risk of major bleeding complications. In this investigation, we elucidated the antithrombotic capacity of the novel 90-mer RNA aptamer Apta-1 and its underlying mechanism of action.EXPERIMENTAL APPROACH: We utilized three independent in vivo animal models to establish antithrombotic activity and bleeding risk of Apta-1. Several cellular and molecular techniques were utilized to extensively characterize the effects of Apta-1 on primary and secondary haemostasis.KEY RESULTS: Apta-1 significantly reduced thrombus weight in ferric chloride-induced carotid artery thrombosis. A consistent reduction in thrombus weight was also observed in arteriovenous shunt thrombosis in rats, whereas tail bleeding time was unaffected. Cellular and molecular analyses revealed that Apta-1 interacted with thrombin, resulting in significant inhibition of protease-activated receptor (PAR) signalling in platelets. On the other hand, Apta-1 shortened both thrombin generation and thrombin-induced clotting times.CONCLUSIONS AND IMPLICATIONS: Apta-1 targets the heparin-binding motif exosite II on thrombin leading to significant suppression of platelet PAR1 and PAR4 signalling. Intriguingly, Apta-1 produces substantial antithrombotic activity without anticoagulant or general antiplatelet properties. In fact, we found that Apta-1 accelerates the formation of blood clots and thus supports haemostasis without exhibiting typical anticoagulant properties. We suggest that Apta-1 may be a promising future drug candidate for treatment of thrombosis in diseases/conditions where there are significant risks of serious bleeding complications.}, issn = {0007-1188} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_liedbergfredrik_2025, title = {Applicability of the European Association of Urology 2021 Prognostic Model for Non-muscle-invasive Bladder Cancer in a Swedish Population-based Cohort}, author = {Liedberg, Fredrik and Hagberg, Oskar and Beijert, Irene J. and Aljabery, Firas and Gårdmark, Truls and Hosseini, Abolfazl and Jahnson, Staffan and Jerlström, Tomas and Kjölhede, Henrik and Malmström, Per-Uno and Ströck, Viveka and Söderkvist, Karin and Ullén, Anders and van Rhijn, Bas W. G. and Holmberg, Lars and Haggström, Christel}, year = {2025}, journal = {European Urology Open Science}, volume = {80}, pages = {33--37}, doi = {10.1016/j.euros.2025.08.003}, url = {1999824}, language = {eng}, publisher = {Elsevier}, keywords = {non-muscle-invasive bladder cancer; adjuvant treatment; primary radical cystectomy; progression risk; prognostic mode}, abstract = {The European Association of Urology (EAU) 2021 prognostic model for non-muscle-invasive bladder cancer (NMIBC) is based on the World Health Organization (WHO) 1973 and/or WHO 2004/2022 grading systems for patients who did not receive bacillus Calmette-Gu & eacute;rin (BCG) instillations and is widely used to assess the risk of progression. The estimated risk of progression affects the type of adjuvant intravesical instillation (chemotherapy or BCG), with primary radical cystectomy recommended for patients with the highest risk of progression. We applied the EAU 2021 prognostic model in a population-based setting for 3392 patients with primary NMIBC diagnosed in 2013-2014 according to the BladderBaSe 2.0 database. We assessed the model calibration by comparing the 5-yr progression probability observed in our cohort with the predicted progression probability assigned for the risk groups in the original EAU study, and evaluated the discrimination according to Harrell's C index. At 5-yr follow-up, 394 patients had experienced disease progression. The progression probability observed was 4.9% (95% confidence interval [CI] 3.5-6.3%), 8.6% (95% CI 6.9-10%), 25% (95% CI 22-28%), and 23% (95% CI 14-30%) for the low-, intermediate-, high-, and very high-risk groups, respectively. The discrimination at 5 yr was 0.72 (95% CI 0.69-0.78) for the overall cohort and 0.74 (95% CI 0.70-0.80) in the group excluding the 811 patients who received BCG instillations. Showing moderate predictive ability, the EAU 2021 prognostic model has clinical utility in population-based settings despite underestimation of the observed progression risk in the low-and high-risk groups in the current study. Patient summary: W of non-muscle-invasive bladder cancer using results for a group of Swedish patients. Approxim more advanced dis e looked at how well a model predicted the risk of progression ately one in four patients in the high-risk category progress to ease within 5 yr. Doctors and patients need to consider the probability of progr on which treatment ess ion in the high-risk category when making shared decisions is best for an individual patient. (c) 2025 The Author(s). Urology. This is an op Published by Elsevier B.V. on behalf of European Association of en access article under the CC BY-NC-ND license (http://creative-commons.org/licenses/by-nc-nd/4.0/).}, issn = {2666-1691} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_orzikhyurii_2025, title = {Application of EU law and the law of EU Member States in Ukraine and of Ukrainian law in EU Member States}, author = {Orzikh, Yurii}, year = {2025}, pages = {462--488}, doi = {10.32837/11300.29672}, url = {1964785}, language = {ukr}, publisher = {Phoenix}, keywords = {private international law; applicable law; application of eu law in ukraine; ukrainian law as applicable law; recognition and enforcement of foreign judgments.}, abstract = {This chapter examines problematic issues concerning the application of EU law and the law of EU Member States in Ukraine and the law of Ukraine in EU Member States. The full-scale invasion of Ukraine by the Russian Federation has had many unprecedented consequences, including the migration of Ukrainian population to EU countries on an unprecedented scale. From the perspective of private international law, it is a matter of time before such migration will give rise to legal situations with a foreign element within the meaning of private international law, and the relevant rules will need to be applied. In recent years, the number of cases involving a foreign element has increased significantly in the judicial and notarial practice of Ukraine. This raises a number of questions that are classic for private international law: which court/notary has jurisdiction to hear the case? Which law is applicable in a specific situation? How are court decisions and authentic instruments originating in Ukraine or an EU country recognised and enforced? In addition, this chapter examines the existing provisions of Ukrainian law that provide preliminary answers to these questions, EU regulations and the case law of the Court of Justice of the European Union.}, file = {https://oru.diva-portal.org/smash/get/diva2:1964785/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fagevikolsnmonika_2025, title = {Applications of positive expiratory pressure in spontaneous breathing : why, when and how?}, author = {Fagevik Olsén, Monika and Sehlin, Maria and Danielsbacka, Jenny and Nygren-Bonnier, Malin and Svensson-Raskh, Anna and Westerdahl, Elisabeth and Lannefors, Louise}, year = {2025}, journal = {Breathe}, volume = {21}, number = {3}, doi = {10.1183/20734735.0164-2025}, url = {1991329}, language = {eng}, publisher = {European Respiratory Society}, abstract = {In spontaneously breathing patients, breathing exercises with positive expiratory pressure (PEP) can be used in various physiological ways to reopen closed airways by increasing the functional residual capacity (FRC) in hypoventilating patients, handle dyspnoea by decreasing the FRC, or reopen clogged airways and maintain an expiratory flow at low lung levels as part of airway clearance therapy. To make the most out of the treatment, the caregiver needs to know the pathophysiology and desired physiological effect of the treatment plan. This article presents the background of the application of PEP and gives information about frequently asked clinical questions. Based on this knowledge, individual prescriptions should be given to each patient including correct instruction and training on how to use PEP and how to adjust when the situation/condition changes. If daily long-term treatment is recommended, the patient needs regular return visits to monitor the effectiveness and evaluate it together with the patient, and to re-educate the patient as soon as needed.}, issn = {1810-6838} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_demydyukganna_2025, title = {Applying the Synergy of Experience Accounting and Service Dominant Logic to measure Customer Experiences in Cruising}, author = {Demydyuk, Ganna and Carlbäck, Mats}, year = {2025}, journal = {Journal of Global Hospitality and Tourism}, url = {1988363}, language = {eng}, publisher = {USF M3 Publishing} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bergbomsofia_2025, title = {Approaching persistent pain and emotion dysregulation : Development of the hybrid emotion-focused exposure treatment}, author = {Bergbom, Sofia and Zetterberg, Hedvig and Flink, Ida Katrina and Linton, Steven J. and Boersma, Katja}, year = {2025}, journal = {Der Schmerz (Berlin. Print)}, volume = {39}, pages = {237--243}, doi = {10.1007/s00482-025-00885-7}, url = {1959265}, language = {eng}, publisher = {Springer}, keywords = {chronic pain; depression; emotion regulation; psychological distress; treatment implementation}, abstract = {BACKGROUND: Persistent pain, one of the most common reasons for suffering and health care seeking, often co-occurs with emotional problems such as depression and anxiety. Within the Center for Health and Medical Psychology at Örebro University, Sweden, we have developed a new treatment aimed at addressing co-occurring persistent pain and emotional problems: hybrid emotion-focused exposure treatment. The overarching idea behind the treatment is that patients who struggle with comorbid pain and emotional problems need to develop skills in dealing with emotions as well as pain. With better skills in tolerating and soothing difficult emotions, patients will be more able to approach previously avoided stimuli and situations, such as movements, activities and social interaction.OBJECTIVES: This review aims to delineate the development of the hybrid emotion-focused exposure treatment. It begins by outlining the theoretical background, then proceeds to describe the techniques, discuss the evidence and conclude with an illustrative case example.RESULTS: Thus far, the treatment has been tested in a single-case study and a randomized controlled trial with promising outcomes. Overall, the hybrid treatment seems to have a good effect on patients' depressive symptoms and pain interference. The treatment is currently being implemented, and the implementation process evaluated, in primary and specialist care across Sweden.CONCLUSIONS: The hybrid emotion-focused exposure treatment seems to be a well-suited treatment for people with a high burden of persistent pain and emotional difficulties. There is good reason to implement the treatment in clinical practice and continue evaluating treatment effects across different contexts.}, issn = {0932-433X} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_bocklandtsieben_2025, title = {Approximate Compression of CNF Concepts}, author = {Bocklandt, Sieben and Derkinderen, Vincent and Kimmig, Angelika and De Raedt, Luc}, year = {2025}, volume = {15244}, pages = {149--164}, doi = {10.1007/978-3-031-78980-9_10}, url = {1952315}, language = {eng}, publisher = {Springer}, keywords = {concept learning; formula compression}, abstract = {We consider a novel concept-learning and merging task, motivated by two use-cases. The first is about merging and compressing music playlists, and the second about federated learning with data privacy constraints. Both settings involve multiple learned concepts that must be merged and compressed into a single interpretable and accurate concept description. Our concept descriptions are logical formulae in CNF, for which merging, i.e. disjoining, multiple CNFs may lead to very large concept descriptions. To make the concepts interpretable, we compress them relative to a dataset. We propose a new method named CoWC (Compression Of Weighted Cnf) that approximates a CNF by exploiting techniques of itemset mining and inverse resolution. CoWC compresses the CNF size while also considering the F1-score w.r.t. the dataset. Our empirical evaluation shows that CoWC outperforms alternative compression approaches.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_humblematsb_2025, title = {Aquaporin-4 positive extracellular vesicles and cytokines in cerebrospinal fluid in schizophrenia and obsessive-compulsive disorder, and associations with peripheral cytokines}, author = {Humble, Mats B. and Mobarrez, Fariborz and Eklund, Daniel and Bejerot, Susanne and Wetterberg, Lennart}, year = {2025}, journal = {Schizophrenia Research}, volume = {284}, pages = {195--203}, doi = {10.1016/j.schres.2025.08.006}, url = {1990229}, language = {eng}, publisher = {Elsevier}, keywords = {astrocyte-derived extracellular vesicles; b-cell depletion; csf; cytokines; ocd; schizophrenia; treatment-resistant}, abstract = {Schizophrenia and obsessive-compulsive disorder (OCD) are complex neuropsychiatric disorders with emerging evidence implicating immune and neuroinflammatory mechanisms. This exploratory pilot study investigated aquaporin-4 positive (AQP4+) extracellular vesicles (EVs) in the cerebrospinal fluid (CSF) of 11 treatment-resistant patients with schizophrenia (n = 5) or obsessive-compulsive disorder (OCD, n = 6) receiving an add-on, single-infusion rituximab (1000 mg) treatment, a B-cell depleting therapy. CSF samples were collected pre-treatment and, for a subset, again five months post-treatment. AQP4+ EV levels in CSF were quantified using flow cytometry with antibodies targeting different regions of the AQP4 molecule. We also measured selected cytokines in CSF and plasma and cytokine gene expression in peripheral blood cells. Patients with schizophrenia exhibited higher AQP4+ EV levels compared to those with OCD. In schizophrenia, AQP4+ EVs correlated positively with the inflammatory marker CXCL8/IL-8 but negatively with CSF-TNF-α. Plasma markers CXCL8/IL-8 and TGF-β1 were positively associated with CSF-AQP4+ EVs in schizophrenia. Between 24- and 40-times higher concentrations of CXCL8/IL-8 in CSF than in plasma suggest intrathecal production of this chemokine in both disorders. Post-treatment, AQP4+ EV levels decreased in the patients who improved following rituximab but remained stable in non-responders. These findings suggest that astrocyte-derived extracellular vesicles may play a role in neuroinflammatory processes linked to schizophrenia and possibly also to severe OCD. The observed relationships between AQP4+ EVs and cytokines support the hypothesis that astrocyte-derived EVs could modulate intrathecal immune responses and potentially also interact with peripheral immune mechanisms. Larger studies are warranted to validate these preliminary findings.}, issn = {0920-9964} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_petersonhelen_2025, title = {Arbete och kön}, author = {Peterson, Helen and Allard, Karin}, year = {2025}, pages = {387--404}, url = {2019377}, language = {swe}, publisher = {Studentlitteratur AB} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_brighentea_2025, title = {Are Flow Correlation Attacks Effective on Tor? A Critical Evaluation of State-of-the-Art Proposals}, author = {Brighente, A. and Cipolletta, L. and Conti, Mauro and Latini, L.}, year = {2025}, doi = {10.1109/CNS66487.2025.11194940}, url = {2028799}, language = {eng}, publisher = {IEEE}, abstract = {Tor is currently the most widely used anonymity network, providing anonymity to both users and hidden services. However, a wide range of attacks proposed in the literature claim the capability of de-anonymizing its users. Among the others, Flow Correlation Attacks aiming at discovering the activity of a specific target user present impressive results in the literature. Specifically, recent attacks such as DeepCoFFEA (S&P'22), and SUMo (NDSS'24) show more then 90% precision in correlating users and their traffic. However, when investigating Tor's past efforts in mitigating this kind of attack, we formulated the following research question: how realistic and effective are these attacks on state-of-the-art Tor networks?In this paper, we answer this question by evaluating state-of-the-art attacks and mitigations. We create a novel dataset of Tor traffic in five different scenarios, leveraging both the latest available Tor implementation and state-of-the-art defenses. We also proposed and evaluated a novel countermeasure. We then used our collected data to test two recent and prominent flow correlation attacks, i.e., SUMo (NDSS'24) and ESPRESSO (2024), a refinement of DeepCoFFEA (S&P'22). Our experimental results demonstrate that both ESPRESSO and SUMo are ineffective at correlating Tor traffic, achieving 8% accuracy and 12% accuracy, respectively. By investigating the motivations behind these results, we discuss how mitigation developed by Tor substantially reduced the risks associated with such attacks, thereby strengthening user anonymity.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hannaamy_2025, title = {Are participation rights a lingua franca? The complexities of translating and comparing the term 'participation' in educational contexts}, author = {Hanna, Amy and Moody, Zoe and Perry-Hazan, Lotem and Darbellay, Fréderic and Gawlicz, Katarzyna and Gillett-Swan, Jenna and Heard, Evie and Louviot, Maude and Quennerstedt, Ann and Zak-Doron, Idan}, year = {2025}, journal = {Childhood}, volume = {32}, number = {4}, pages = {541--557}, doi = {10.1177/09075682251367557}, url = {1995103}, language = {eng}, publisher = {Sage Publications}, keywords = {meaning; participation; signification; translation; uncrc}, abstract = {Children's right to express their views under article 12 of the United Nations Convention on the Rights of the Child is commonly referred to as 'participation'. How this term is used in scholarship, policy and practice, however, varies enormously across linguistic and national contexts. This article reports and discusses four complexities associated with translating and comparing the term participation that were identified from a series of international workshops on children's rights in education. We conclude that further empirical, interdisciplinary research is required to examine these complexities in further depth.}, issn = {0907-5682} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rekolaamanda_2025, title = {Areolar sebaceous hyperplasia : case report and literature review}, author = {Rekola, Amanda and Tegnelius, Daniel and Wall, Emma and Zdolsek, Johann and Tabrisi, Reza}, year = {2025}, journal = {Case Reports in Plastic Surgery and Hand Surgery}, volume = {12}, number = {1}, doi = {10.1080/23320885.2025.2487843}, url = {1953457}, language = {eng}, publisher = {Taylor & Francis Group}, keywords = {areolar sebaceous hyperplasia; nipple lesion; montgomery's tubercles; montgomery hyperplasia; areola; sebaceous neoplasm; nac}, abstract = {Areolar sebaceous hyperplasia (ASH), also known as Montgomery hyperplasia, is an uncommon benign neoplasm. Despite nearly 40 years since the first case was described, this condition remains rare, with only 20 reported cases. We present a case of ASH in a 44-year-old female and review the existing literature.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_thunbergsara_2025, title = {Arriving at the shelter – mothers’ narratives of their children’s experiences}, author = {Thunberg, Sara and Arnell, Linda}, year = {2025}, journal = {Nordic Social Work Research}, volume = {15}, number = {1}, pages = {96--107}, doi = {10.1080/2156857X.2023.2274990}, url = {1810985}, language = {eng}, publisher = {Routledge}, keywords = {children; domestic violence shelter; fleeing; intimate partner violence; leaving}, abstract = {Each year a large number of children are exposed to violence in their homes, for example, by witnessing one parent using violence against the other, or experiencing violence directed at them personally. As a result, together with a parent, often the mother, the children might need to flee from the violence to a domestic violence shelter. The present study is set in a Swedish context and aims to analyse mothers’ narratives of the initial time at a domestic violence shelter for mothers and their young children (aged 0–6), with a focus on children’s right to protection and participation. The study consists of interviews with thirteen mothers, which are analysed using thematic analysis. The findings show that the children rarely know why they are at the shelter, and that it is an unfamiliar place for them, as they have little knowledge of what a shelter is. The children also seem to be afraid of losing their mothers, which is expressed in how they monitor their mothers. Based on the findings, the children need to build trustful relationships, a process that takes time but can already begin on the first day at the shelter. The first day signifies the start of something different, which means that the mothers and children need time to settle into their new lives.}, issn = {2156-857X}, file = {https://oru.diva-portal.org/smash/get/diva2:1810985/FULLTEXT01.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_meertwannes_2025, title = {Artificial Intelligence A Perspective from the Field}, author = {Meert, Wannes and De Laet, Tinne and De Raedt, Luc}, year = {2025}, pages = {17--39}, doi = {10.1017/9781009367783.003}, url = {2033665}, language = {eng}, publisher = {Cambridge University Press}, keywords = {machine learning; machine reasoning} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_engbergerik_2025, title = {Artificial intelligence, hiring and employment : job postings evidence from Sweden}, author = {Engberg, Erik and Hellsten, Mark and Javed, Farrukh and Lodefalk, Magnus and Sabolová, Radka and Schroeder, Sarah and Tang, Aili}, year = {2025}, journal = {Applied Economics Letters}, doi = {10.1080/13504851.2025.2497431}, url = {1958574}, language = {eng}, publisher = {Routledge}, keywords = {technological change; automation; labour demand}, abstract = {This paper investigates the impact of artificial intelligence (AI) on hiring and employment, using the universe of job postings published by the Swedish Public Employment Service from 2014 to 2022 and full-population administrative data for Sweden. We exploit a detailed measure of AI exposure according to occupational content and find that establishments exposed to AI are more likely to hire AI workers. Survey data further indicate that AI exposure aligns with greater use of AI services. Importantly, rather than displacing non-AI workers, AI exposure is positively associated with increased hiring for both AI and non-AI roles. In the absence of substantial productivity gains that might account for this increase, we interpret the positive link between AI exposure and non-AI hiring as evidence that establishments are using AI to augment existing roles and expand task capabilities, rather than to replace non-AI workers.}, issn = {1350-4851} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_engbergerik_2025_1, title = {Artificial intelligence, tasks, skills, and wages : Worker-level evidence from Germany}, author = {Engberg, Erik and Koch, Michael and Lodefalk, Magnus and Schroeder, Sarah}, year = {2025}, journal = {Research Policy}, volume = {54}, number = {8}, doi = {10.1016/j.respol.2025.105285}, url = {1986554}, language = {eng}, publisher = {Elsevier}, keywords = {artificial intelligence technologies; task content; skills; wages}, abstract = {This paper examines how new technologies are linked to changes in the content of work and individual wages. As a first step, it documents novel facts on task and skill changes within occupations over the past two decades in Germany. We furthermore reveal a distinct relationship between ex-ante occupational work content and ex-post exposure to artificial intelligence (AI) and automation (robots). Workers in occupations with high AI exposure perform different activities and face different skill requirements compared to workers in occupations exposed to robots, suggesting that robots and AI are substitutes for different activities and skills. We also document that changes in the task and skill content of occupations is related to ex-ante exposure to technologies. Finally, the study uses individual labour market biographies to investigate the relationship between AI and wages. By exploring the dynamic influence of AI exposure on individuals over time, the study uncovers positive associations with wages, with nuanced variations across occupational groups, thereby shedding further light on the substitutability and augmentability of AI.}, issn = {0048-7333} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_arvidssonolof_2025, title = {ASD and ADHD symptoms in 18-year-olds - A population-based study of twins born 1993 to 2001}, author = {Arvidsson, Olof and Brikell, Isabell and Larsson, Henrik and Lichtenstein, Paul and Kuja-Halkola, Ralf and Johnson, Mats and Gillberg, Christopher and Lundström, Sebastian}, year = {2025}, journal = {Psychiatry Research}, volume = {351}, doi = {10.1016/j.psychres.2025.116613}, url = {1981283}, language = {eng}, publisher = {Elsevier}, keywords = {adhd; asd; attention-deficit/hyperactivity disorder; autism spectrum disorder; prevalence; autism}, abstract = {BACKGROUND: The diagnostic prevalences of Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) have increased dramatically over the past two decades in the western world, particularly among teenagers and young adults. Here, we aimed to investigate whether there had been a corresponding increase in parent reported symptoms of ASD and ADHD in a population-based sample of 18-year-old twins born between 1993-2001.METHODS: Data were collected in the Child and Adolescent Twin Study in Sweden (CATSS), in which parents report on symptoms of ASD and ADHD in connection with their children´s 18th birthday. Trends across 9 consecutive birth years in reported symptoms were analyzed as population mean scores and with percentile-based cut-offs using linear and logistic regression methods.RESULTS: For ASD, there was no increase in the symptom phenotype across the examined birth years, neither at the population mean level nor at or above the 95th percentile of the ASD symptom score. For ADHD, there was a small - but statistically significant - increase over time of the population mean ADHD symptom score in girls (regression coefficient: 0.046 (95 % Confidence interval 0.025 - 0.066). p < 0.001), but not in boys. The prevalence at or above the 90th percentile of the ADHD symptom score was stable in boys but increased statistically significantly in girls (Odds Ratio: 1.053 (95 % Confidence interval 1.016-1.094). p = 0.005).CONCLUSIONS: The rise in clinical diagnoses of ASD and ADHD in the adolescent/young adult population does not seem to be parallelled by a similar increase in ASD and ADHD symptoms.}, issn = {0165-1781} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_suchanjakob_2025, title = {ASP-driven visual commonsense : A general framework for reasoning about embodied interaction in the wild}, author = {Suchan, Jakob and Bhatt, Mehul and Monsen, Julius}, year = {2025}, pages = {632--642}, doi = {10.24963/kr.2025/61}, url = {2024225}, language = {eng}, publisher = {AAAI Press, International Joint Conferences on Artificial Intelligence (IJCAI)}, abstract = {We present a general framework for declaratively grounded visual commonsense (reasoning) about embodied interaction in naturalistic, in-the-wild settings relevant to a range of AI application domains. The core computational capabilities of the framework pertaining visual commonsense are driven by a robust neurosymbolic architecture primarily consisting of: (1) answer set programming based modelling of foundational aspects pertaining spatio-temporal dynamics, encompassing space, time, events, action, motion; (2) modularly integrated visual computing techniques constituting the neural substrate linking quantitative perceptual features serving as low-level counterparts to high-level semantic characterisations of (inter)active visual commonsense.Practically, we also present a first open-release of the developed framework with the aim to promote independent extensions and real-world applied KRR. The release comprises: (a) demonstrated case-studies in domains such as autonomous driving, psychology and media studies; (b) systematic evaluation mechanisms for community benchmarking; and (c) supporting material such as tutorials and datasets.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_stlinghanna_2025, title = {Aspects of placental inflammatory response and birth weight, with specific focus on SARS-CoV-2 infection during pregnancy}, author = {Östling, Hanna}, year = {2025}, url = {1934499}, language = {eng}, publisher = {Örebro University}, keywords = {birth weight; cope-study; covid-19; foetal growth; inflammatory response; microrna; placenta; pregnancy; proteomics; sars-cov-2; small for gestational age}, abstract = {Placental function and foetal growth can be influenced by environmental factors or maternal medical conditions. The aim of this thesis was to characterise biological pathways in the placenta of importance for normal and impaired foetal growth, and to investigate whether maternal SARS-CoV-2 infection affects placental protein expression or is clinically associated with aberrant newborn birth weight. In study I, placental microRNA and protein expression profiles were characterised in pregnancies with normal newborn birth weights. Study II explored microRNA expression in placentas from pregnancies complicated by small-for-gestational-age (SGA) newborns. In study III, the impact of maternal SARS-CoV-2 infection on placental levels of inflammatory and cardiovascular proteins was investigated. In study IV, potential associations between maternal SARS-CoV-2 infection with aberrant birth weight, was investigated using Swedish registers. Inflammatory response, lipid metabolism, and neurodevelopment were highlighted as key biological processes in the healthy term placenta, suggesting that these pathways may be particularly susceptible to environmental insults and maternal disease. In SGA placentas, eight microRNAs were found to be differentially expressed and connected with inflammation and the insulin/IGF system. These findings indicate that subclinical inflammation, through disturbances in the insulin/IGF system, may be involved in unexplained SGA births. For pregnancies complicated by maternal SARS-CoV-2 infection, no persistent changes were seen in placental levels of inflammatory or cardiovascular proteins in term birth. Further, in the general pregnant population, maternal SARS-CoV-2 infection was not associated with an increased risk of SGA or abnormal birth weight at term, regardless of infection timing or severity.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_camachodoylemaria_2025, title = {Assessing Crime History as a Predictor : Exploring Hotspots of Violent and Property Crime in Malmö, Sweden}, author = {Camacho Doyle, Maria and Gerell, Manne}, year = {2025}, journal = {International Criminal Justice Review}, volume = {35}, number = {1}, pages = {43--61}, doi = {10.1177/10575677241230915}, url = {1837336}, language = {eng}, publisher = {Sage Publications}, keywords = {microplace; prediction-accuracy; prediction-efficiency; violent-crime; property-crime}, abstract = {Objectives: Assessing the predictive accuracy of using prior crime, place attributes, ambient population, community structural, and social characteristics, in isolation and combined when forecasting different violent and property crimes.Method: Using multilevel negative binomial regression, crime is forecasted into the subsequent year, in 50-m grid-cells. Incidence rate ratio (IRR), Prediction Accuracy Index (PAI), and Prediction Efficacy Index (PEI*) are interpreted for all combined crime generators and community characteristics. This study is partially a test of a crude version of the Risk Terrain Modeling technique.Results: Where crime has been in the past, the risk for future crime is higher. Where characteristics conducive to crime congregate, the risk for crime is higher. Community structural characteristics and ambient population are important for some crime types. Combining variables increases the accuracy for most crime types, looking at the IRR. Taking the geographical area into account, crime history in combination with both place- and neighborhood characteristics reaches similar accuracy as crime history alone for most crime types and most hotspot cutoffs.Conclusions: Crime history, place-, and neighborhood-level attributes are all important when trying to accurately forecast crime, long-term at the micro-place. Only counting past crimes, however, still does a really good job.}, issn = {1057-5677} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_zeinermichaela_2025, title = {Assessing Heavy Metal Contamination from Shooting Ranges : A Case Study of the Munkatorp Shooting Range in Örebro, Sweden}, author = {Zeiner, Michaela and Baysal, Ramazan and Prohaska, Katerina}, year = {2025}, url = {1940003}, language = {eng}, abstract = {Conifer needles have been extensively studied worldwide, particularly in regions impacted by heavy metal pollution from traffic and industrial activities. These studies focus on evaluating the potential of pine needles as bioindicators of environmental contamination, due to their year-round presence. In addition to industrial pollution, shooting ranges are another significant source of heavy metal contamination.Shooting ranges provide a controlled environment for firearm practice and training, yet the environmental impacts of these activities are often overlooked. The discharge of lead and other heavy metals from ammunition poses a serious threat to ecosystems and public health. Lead is a major contaminant, as bullets are typically composed of lead or contain lead-based components. When fired, these bullets release lead particles into the environment, contaminating soil and water. Over time, the accumulation of lead in the ecosystem can have harmful effects on plants, wildlife, and human health.One such area of concern is the Munkatorp Shooting Range in Örebro, Sweden, which has been identified as a site of significant heavy metal pollution. Although there are plans for decontamination, no substantial actions have been taken to address the contamination so far. Within the designated area, four trees were selected for sampling: two Norway spruces (Picea abies) and two Scots pines (Pinus sylvestris). Needle samples were carefully collected and stored in plastic bags, then washed, dried, and ground into a fine powder for subsequent digestion and analysis. The metal content was quantified using inductively coupled plasma mass spectrometry (ICP-MS) after acidic digestion. The study focused not only on metals commonly associated with ammunition, specifically manganese, iron, nickel, copper, zinc, molybdenum, antimony, and lead, but also on essential elements for plants to better understand the environmental impact of the pollution in this area. Furthermore, the needles underwent analysis via Raman Spectroscopy to get information on the metabolic state of the plant material, which provides deeper inside on the soil conditions on the growing site of the conifers. The analysis of conifer needles revealed no significant contamination attributable to the shooting range. Instead, it highlighted species-specific variations in metal contents, but within the ranges reported in literature. Species-specific differences were also found using Raman Spectroscopy.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_torensmabart_2025, title = {Assessing the FAIRness of Metabolic Bariatric Surgery Registries : a Comparative Analysis of Data Dictionaries from the UK, Germany, France, Netherlands, Norway, and Sweden}, author = {Torensma, Bart and Hany, Mohamed and Fink, Jodok M. and Ahmed, Ahmed R. and Liem, Ronald S. L. and Lazzati, Andrea and Pattou, François and Ottosson, Johan and Kersloot, Martijn G.}, year = {2025}, journal = {Obesity Surgery}, volume = {35}, number = {3}, pages = {1036--1044}, doi = {10.1007/s11695-025-07701-2}, url = {1935303}, language = {eng}, publisher = {Springer}, keywords = {data modeling; fair; metabolic bariatric surgery; registry}, abstract = {BACKGROUND: This study is part of an initiative to improve the FAIRness (Findability, Accessibility, Interoperability, Reusability) of metabolic bariatric surgery (MBS) registries globally. It explores the extent to which European registry data can be manually integrated without first making them FAIR and assesses these registries' current level of FAIRness. The findings establish a baseline for evaluation and provide recommendations to enhance MBS data management practices.METHODS: Data dictionaries from five national MBS registries in Germany, France, the Netherlands, the UK, and a combined registry for Scandinavia (Norway and Sweden) were evaluated regarding their ability to manually integrate registry datasets with one another. The FAIR Data Maturity Model from the Research Data Alliance (RDA) FAIR Data Maturity Model Working Group was used to assess the FAIRness of both metadata and data of the registries.RESULTS: The registries showed significant variability in variables and coding structures, with inconsistent numerical formats and without linkage to international standards such as SNOMED CT, LOINC, or NCIt, making data integration labor-intensive and assumption-heavy. Despite the presence of data dictionaries, all registries failed the FAIR assessment because machine-readable data was unavailable, and only human-readable metadata was available in the form of data dictionaries in a spreadsheet.CONCLUSION: Our study reveals significant inconsistencies in data structuring and a failure to comply with the FAIR Principles, which limit effective data analysis and comparison. This emphasizes the critical need for standardized data management practices. We recommend four next steps to improve the FAIRness of MBS registries: (1) annotate data elements using standardized terminology systems, (2) deposit registry-level metadata in a repository, (3) request globally unique and persistent identifiers for datasets, and (4) define access restrictions.}, issn = {0960-8923} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_erikssonmats_2025_2, title = {Assessment and management of procedural pain in wounded children}, author = {Eriksson, Mats and Nilsson, Stefan}, year = {2025}, pages = {491--489}, url = {1980324}, language = {eng}, publisher = {Minerva Medica}, keywords = {pain; children; wounds} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tolgforsbjrn_2025_1, title = {Assessment for and of learning in nonlinear movement education practices}, author = {Tolgfors, Björn and Barker, Dean and Nyberg, G. and Larsson, H.}, year = {2025}, journal = {Physical Education and Sport Pedagogy}, volume = {30}, number = {3}, pages = {324--337}, doi = {10.1080/17408989.2023.2230244}, url = {1782118}, language = {eng}, publisher = {Routledge}, keywords = {nonlinear teaching and learning; alternative assessment; exploratory teaching methods; movement learning; school physical education}, abstract = {Background: Principles such as instructional alignment and step-by-step progression are often seen as crucial features of good assessment practices in school physical education (PE). These features are problematic from nonlinear educational perspectives, which are based on the idea that movement learning cannot be expected to take place in the same manner for all students. Without some resolution of the contradiction between nonlinear pedagogies and principles of good assessment, the likelihood of physical educators fully embracing any kind of nonlinear approach to movement education remains doubtful.Purpose and research question: Our purpose in this paper is to illustrate how assessment for and of learning (AfL and AoL) can look when implemented in nonlinear movement education practices.  Methods: Illustrations of AfL and AoL are drawn from an investigation in which one educator implements a nonlinear movement education module. The module focuses on juggling for students at high school (grade nine students aged approximately 15 years). The module provided students with 10 x 50-minute lessons to explore juggling. Data were generated through observations (film clips and field notes) and ethnographic-type interviews that were conducted with the students during the lessons.Findings: In the context of the nonlinear movement education module, AfL became: Interacting with students in joint exploration; Introducing learning strategies; Encouraging students to clarify and verbalize the object of learning; Helping students identify critical aspects of the movement activity, and; Inviting students to consider alternative learning trajectories. The educator then evaluates the students’ learning experiences in the context of a group performance at the end of the module. This performance can be seen as an instance of holistic assessment within a nonlinear movement education practice. Conclusions: The suggested holistic perspective on PE assessment could help educators to: circumvent dichotomies such as mind-body and theory-practice; approach students as active meaning-makers; re-frame students’ actions as emergent and context-dependent; and replace direct instruction with explorative teaching and learning methods. The major contribution of this study is that it shows how assessment for and of learning can be implemented in nonlinear movement education practices within a linear, goal-related and criterion-referenced, education system.}, issn = {1740-8989}, file = {https://oru.diva-portal.org/smash/get/diva2:1782118/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hesselmansusanne_2025, title = {Assessment of childbirth experience over time-A prospective cohort study}, author = {Hesselman, Susanne and Sten, Wilma and Skogsdal, Yvonne Rosalie Elisabeth and Wikman, Anna and Viirman, Frida}, year = {2025}, journal = {Acta Obstetricia et Gynecologica Scandinavica}, volume = {104}, number = {9}, pages = {1766--1773}, doi = {10.1111/aogs.70010}, url = {1981276}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {maternal‐child nursing; parturition; survey methods; traumatic stress disorders}, abstract = {INTRODUCTION: A woman's childbirth experience is multifaceted and has a great impact on not only the woman, but also the family's health and well-being. Changes in childbirth experience over time have been evaluated with a variety of instruments, at different time points, and with inconsistent findings. In Sweden, the rating of birth experience is routinely collected after birth, but it is still unknown which time point is preferred from a clinical perspective. The primary aim was to investigate changes in childbirth experience over time from childbirth to 6 months postpartum, assessed by both a single and a multi-item instrument. A secondary aim was to test the correlation between these instruments.MATERIAL AND METHODS: In a prospective cohort study, 320 women were recruited from two Swedish hospitals. Study participants completed a survey at the maternity ward after giving birth, and again three and 6 months postpartum, rating their overall childbirth experience on a single item 10-point numeric rating scale (NRS) and a multi-item instrument, the Childbirth Experience Questionnaire 2 (CEQ2), encompassing four known dimensions of childbirth: Perceived safety, Own capacity, Participation and Professional support. Changes in childbirth experience (NRS and CEQ2) over time were analyzed using the Friedman test. NRS ratings were analyzed in relation to CEQ2 dimensions with Spearman's correlation. RESULTS: Overall childbirth experience rated using NRS did not change over time. The total CEQ2 score decreased significantly from childbirth to 6 months postpartum (p < 0.001). This change was driven by decreased scoring of the domains Participation and Professional support. The correlations between NRS and CEQ scores were consistent over time, with a moderate to weak correlation of NRS with Participation and Professional support.CONCLUSIONS: Women perceive their birthing experience more negatively over time when assessed using the CEQ2 questionnaire, but this was not captured by a single-item question assessing overall childbirth experience.}, issn = {0001-6349} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_arnonedanilo_2025, title = {Assessment of cognitive domains in major depressive disorders using the Cambridge Neuropsychological Test Automated Battery (CANTAB) : Systematic review and meta-analysis of cross-sectional and longitudinal studies}, author = {Arnone, Danilo and Ramaraj, Reshma and Östlundh, Linda and Arora, Teresa and Javaid, Syed and Govender, Romona Devi and Stip, Emmanuel and Young, Allan H.}, year = {2025}, journal = {Progress in Neuro-psychopharmacology and Biological Psychiatry}, volume = {138}, doi = {10.1016/j.pnpbp.2025.111301}, url = {1941266}, language = {eng}, publisher = {Elsevier}, keywords = {adults; cantab; cambridge neuro- psychological test automated battery; cognitive function; depression; major depressive disorders; mood disorders}, abstract = {Cognitive difficulties are known to persist after remission of symptoms and to affect psychosocial functioning and quality of life. Cognitive function, measured with the Cambridge Neuro-psychological Test Automated Battery (CANTAB), is a reliable approach to measure cognitive function in major depression. This systematic review and meta-analysis appraise cross-sectional and longitudinal studies that used specific CANTAB tests to measure cognitive function in major depression and the effect of treatment (PROSPERO ID: CRD42022355903). 1212 studies were identified and 41 were included, 1793 patients and 1445 healthy controls. Deficits in executive functions were detected with the Stocking Of Cambridge (SOC) 'number of problems solved with minimal number of moves' and 'subsequent thinking time', Intra-Extra Dimensional Set Shift 'number of trials to complete the test', Spatial Working Memory 'strategy score' and 'between errors score', Spatial Span. Memory deficits were detected with Paired Associates Learning 'number of total errors', Pattern Recognition Memory (PRM) '% of correct answers' and 'response latency', Spatial Recognition Memory '% of correct answers', Delayed Matching To Sample (DMS) '% of total responses'. Impaired attention was detected by Rapid Visual Information Processing 'response latency' and probability to detect target'. Mental and motor responses increased when Reaction Time was measured. SOC 'number of problems solved with minimal number of moves', PRM 'response latency' and DMS '% of total responses' improved after a course of treatment. A range of variables including year of publication, age, IQ, severity and duration of illness influenced cognitive changes. The presence of significant cognitive deficits requires novel targeted interventions.}, issn = {0278-5846} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_bojanamii_2025, title = {Assessment of Perfluoroalkyl Substances (PFAS) in MASLD Patients from Serbia : Insights from a Broader Multi-Omics Study}, author = {Bojana, Mićić and Ignjatović, Sofija and Gašić, Uroš and Božić-Antić, Ivana and Bjekić-Macut, Jelica and Barbosa, Joao and Nguyen, Anh Hoang and Duberg, Daniel and Castro Alves, Victor and Orešič, Matej and Hyötyläinen, Tuulia and Djordjevic, Ana and Milutinović, Danijela Vojnović and Veličković, Nataša}, year = {2025}, pages = {276--276}, url = {2030698}, language = {eng}, publisher = {Metabolomcis Society}, keywords = {pfas; masld; metabolomics; environmental exposure; pollutants}, abstract = {Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants with known bioaccumulative properties and increasing recognition for their potential to disrupt metabolic pathways, including bile acid transport and lipid metabolism. Despite growing global attention, data on PFAS exposure and distribution in the Balkan region, including Serbia, remain limited. This work presents preliminary findings on PFAS presence and explores potential associations with bile acid metabolism in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and age-, BMI-, and sex-matched controls, as part of a broader multi-omics investigation. Plasma samples were collected from 122 participants (MASLD patients and matched controls) and metabolites were extracted using a monophasic solution of methanol, methyl tert-butyl ether, and isopropanol (20:15:15) containing internal standards. Extracts were analyzed using ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry on a C18 column. Data processing was performed using MZmine 3 software, and compound annotation was based on an in-house spectral library. Among the detected environmental contaminants, three PFAS compounds—perfluorohexane sulfonic acid (PFHxS) and both linear and branched isomers of perfluorooctane sulfonic acid (PFOS)—were consistently identified across all samples, suggesting widespread low-level exposure in the cohort, with no significant differences in PFAS abundance between MASLD patients and healthy controls. These preliminary results highlight the presence of PFAS compounds in all participants, reflecting a baseline environmental exposure within this population. Although no clear associations with MASLD status were observed, the integration of environmental contaminant data into multi-omics frameworks is critical for uncovering subtle metabolic perturbations. Ongoing analyses will focus on profiling secondary bile acids and microbiota-derived metabolites to explore potential downstream effects of PFAS exposure and their relevance to MASLD pathophysiology.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_laarhannadalia_2025, title = {Assessment of the autonomic response to a high dose CO2 inhalation challenge based on heart rate variability and skin conductance in a healthy population}, author = {Laar, Hanna-Dalia and Carlman, Hanna M. T. and Brummer, Robert Jan and Rode, Julia}, year = {2025}, journal = {IBRO neuroscience reports}, volume = {19}, pages = {836--843}, doi = {10.1016/j.ibneur.2025.10.014}, url = {2014536}, language = {eng}, publisher = {Elsevier}, keywords = {autonomic arousal; electrocardiography; electrodermal activity; hypercapnia; panic (disorder)}, abstract = {Stress induction tests such as carbon dioxide (CO2) inhalation challenges, are often used in research of anxiety and panic disorders. Physiological parameters of the autonomic response, e.g., heart rate variability (HRV) and skin conductance (SC), are often measured alongside questionnaires for evaluation. Previous studies have shown varied results on CO2 inhalation-induced physiological reactivity and further knowledge is of interest. The aim of this study was to explore the effects of a 35 % CO2 inhalation test on HRV frequencies and SC, in healthy subjects; and to set those into relation with subjective psychological ratings. In this single-blinded, repeated measures study, healthy subjects underwent a 35 % CO2 inhalation challenge, whereof the first and third double vital capacity inhalations were with normal air and the second with 35 % CO2. HRV (low and high frequency) and SC (as electrodermal activity (EDA)) were measured throughout. CO2 inhalation resulted in a significant increase of HRV's high and very high frequencies compared to the first air inhalation (median difference + 0.0001633; + 0.0000348) and of HRV's very high and very low frequencies compared to the last air inhalation (+ 0.0000321; + 0.0000154). Mean and maximum SC increased significantly during the CO2 inhalation compared to both air inhalations (mean difference to first air inhalation + 1.151; + 1.964; to last air inhalation + 0.5751; +1.484), but also between the separate air inhalations (+ 0.5754; + 0.4799). The HRV results indicate increased parasympathetic activity, while the SC results indicate increased sympathetic activity during CO2 inhalation. SC only minorly correlated with provoked panic symptoms (EDA minimum to VAS minimum r = -0.559, and not between any other EDA and VAS/PSL measure). While those results seem contradictory, this study confirms that a 35 % CO2 inhalation challenge in young healthy adults, provokes a physiological as well as psychological reaction.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_malmstrmhans_2025, title = {Assigned reading in English : Compliance, comprehension and preparedness among Swedish students}, author = {Malmström, Hans and Eriksson, Linda and Stöhr, Christian}, year = {2025}, journal = {Education Inquiry}, pages = {1--17}, doi = {10.1080/20004508.2025.2590887}, url = {2016898}, language = {eng}, publisher = {Taylor & Francis}, keywords = {academic reading; english reading; student preparedness; reading compliance; reading comprehension}, abstract = {This study investigates Swedish university students’ engagement with academic reading in English, with a focus on reading compliance, perceived comprehension, and preparedness. Based on a nationwide survey (N = 1,000), the study offers a representative account of students’ academic reading practices and experiences. While a majority of students report reading most or all assigned English texts and generally find them comprehensible, a substantial minority read selectively/not at all and struggle with understanding. Many students also feel underprepared for the demands of academic reading in English. These challenges are unevenly distributed and show systematic variation across demographic groups (gender, age, level of education and academic discipline). Overall, the study highlights that academic reading in English is not merely a linguistic challenge but a socially and institutionally shaped practice. The findings call for more coordinated support across educational levels, including stronger alignment between pre-tertiary and tertiary education, and targeted interventions to support students’ developing academic reading literacy. This study contributes to the growing literature on academic reading in non-Anglophone higher education contexts.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zhaiyinghong_2025, title = {Association between an energy-adjusted inflammatory diet index and gastroesophageal reflux disease : a retrospective cohort study}, author = {Zhai, Yinghong and Hu, Fangyuan and Yuan, Lei and Chen, Dafan and Cao, Yang and He, Jia and Han, Xu and Xu, Feng}, year = {2025}, journal = {European Journal of Nutrition}, volume = {64}, number = {4}, doi = {10.1007/s00394-025-03678-x}, url = {1953126}, language = {eng}, publisher = {Steinkopff-Verlag}, keywords = {energy-adjusted inflammatory diet index; gastroesophageal reflux disease; retrospective study; uk biobank}, abstract = {PURPOSE: To examine and quantify the association between an inflammatory diet index and gastroesophageal reflux disease (GERD) utilizing extensive data from a large cohort.METHODS: This study included eligible UK Biobank participants recruited between 2006 and 2010 who had no prior history of GERD and no missing data for key covariates. The primary outcome was incident GERD, identified using the "first occurrence" dataset. 27 eligible food/nutrient parameters derived from the 24-h recall questionnaires in the UK Biobank were included to calculate the energy-adjusted dietary inflammation index (E-DII) score. The E-DII score was employed as a continuous variable in restricted cubic spline regression (RCS) analysis. To facilitate analysis, participants were then categorized into four groups based on quartile values in the subsequent Cox regression analysis adjusting varying degrees of confounding factors.RESULTS: After exclusion, 154,590 participants were included in the primary analysis. Over a mean 12.36-year follow-up, a total of 12, 041(7.79%) participants experienced GERD. The results of multivariable RCS showed that the risk of GERD had a slightly overall increased trend along with E-DII after adjusting the confounding factors. The cumulative incidence of GERD in the four groups was significantly different (P < 0.001) and participants in higher quartiles determined by E-DII had a higher GERD incidence. Results from both univariate and multivariate Cox regression consistently revealed the most pro-inflammatory E-DII group (i.e. the fourth quartile) had a significantly heightened risk of GERD compared to those in the first quartile (crude HR [95% CI] 1.118 [1.063-1.175]; fully adjusted HR [95% CI] 1.136 [1.079-1.196]). Subgroup analyses revealed variations across populations, while sensitivity analyses confirmed the robustness of primary findings.CONCLUSIONS: The current study revealed that that adherence to a diet with high pro-inflammatory potential might be associated with higher GERD incidence and further randomized controlled trials are needed to provide more conclusive evidence.}, issn = {1436-6207} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_changzheng_2025, title = {Association between autism and dementia across generations : evidence from a family study of the Swedish population}, author = {Chang, Zheng and Yao, Honghui and Sun, Shihua and Zhang, Le and Liu, Shengxin and Brikell, Isabell and D'Onofrio, Brian M. and Larsson, Henrik and Lichtenstein, Paul and Kuja-Halkola, Ralf and Hägg, Sara and Happé, Francesca and Taylor, Mark J.}, year = {2025}, journal = {Molecular Psychiatry}, volume = {30}, number = {10}, pages = {4605--4612}, doi = {10.1038/s41380-025-03045-6}, url = {1958436}, language = {eng}, publisher = {Springer Nature}, abstract = {There is emerging evidence to suggest that autistic individuals are at an increased risk for cognitive decline or dementia. It is unknown whether this association is due to shared familial influences between autism and dementia. The main purpose of this study was, thus, to investigate the risk of dementia in relatives of autistic individuals. We conducted a family study based on linking Swedish registers. We identified all individuals born in Sweden from 1980-2013, followed until 2020, and clinical diagnoses of autism among these individuals. We linked these index individuals with their parents, grandparents, and aunts/uncles. The risk of dementia (including any type of dementia, Alzheimer's disease, and other types of dementia) in relatives of autistic individuals was estimated using Cox proportional hazards models. Analyses were then stratified by sex of the relatives and intellectual disability in autistic individuals. Relatives of autistic individuals were at an increased risk of dementia. The risk was strongest in parents (hazards ratio [HR] = 1.36, 95% confidence intervals = 1.25-1.49), and weaker in grandparents (HR = 1.08, 1.06-1.10) and aunts/uncles (HR = 1.15, 0.96-1.38). Furthermore, there were indications of a stronger association between autism in index individuals and dementia in mothers (HR = 1.51, 1.29-1.77) compared to dementia in fathers (HR = 1.30, 1.16-1.45). There was only a small difference in relatives of autistic individuals with and without intellectual disability. Our results provide evidence of familial co-aggregation between autism and different types of dementia, and a potential genetic link. Future research now needs to clarify the risk of dementia in autistic individuals.}, issn = {1359-4184} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_immanueljincy_2025, title = {Association Between Glycemia, Glycemic Variability, and Pregnancy Complications in Early GDM}, author = {Immanuel, Jincy and Cheung, N. Wah and Mohajeri, Mahta and Simmons, Daniel J. and Hague, William M. and Teede, Helena and Nolan, Christopher J. and Peek, Michael J. and Flack, Jeff R. and McLean, Mark and Wong, Vincent and Hibbert, Emily J. and Kautzky-Willer, Alexandra and Harreiter, Jürgen and Backman, Helena and Gianatti, Emily and Sweeting, Arianne and Mohan, Viswanathan and Simmons, David}, year = {2025}, journal = {Diabetes Care}, volume = {48}, number = {2}, pages = {285--291}, doi = {10.2337/dc24-1199}, url = {1921042}, language = {eng}, publisher = {American Diabetes Association}, abstract = {OBJECTIVE: To investigate the association of timing of commencing glucose management with glycemia, glycemic variability, and pregnancy outcomes among women with early gestational diabetes mellitus (GDM).RESEARCH DESIGN AND METHODS: In this substudy among participants of a trial of immediate vs delayed treatment of early GDM diagnosed by 2013 World Health Organization criteria, all women treated immediately and those with delayed diagnosis at 24-28 weeks' gestation (treated as if late GDM) were instructed to monitor capillary blood glucose (BG) four times a day (fasting and 2-h postprandial) until delivery. Optimal glycemia was defined as ≥95% of BG measurements between 70 and 140 mg/dL (3.9-7.8 mmol/L).RESULTS: Overall, 107,716 BG values were obtained from 329 of 549 (59.9%) women (mean age 32.3 ± 4.9 years, BMI 32.0 ± 8.0 kg/m2, 35% European, gestation at GDM diagnosis 15.2 ± 2.4 weeks). Women treated early (n = 213) showed lower mean glucose (MG) and mean fasting glucose (MFG) compared with those treated late (n = 116) (MG: 5.7 ± 0.4 vs. 5.9 ± 0.5, P < 0.001; MFG: 5.2 ± 0.3 vs. 5.3 ± 0.4, P = 0.004), with greater optimal glycemia (74.6% vs. 59.5%, P = 0.006) and similar glycemic variability. MG was similar from 30 weeks' gestation. Overall, optimal glycemia was achieved in 69% of women and associated with lower birth weight, fewer large-for-gestational-age infants (14.4% vs. 26.7%, P = 0.01), more small-for-gestational-age infants (15.3% vs. 5.9%, P = 0.02), and lower gestational weight gain (4.9 ± 6.4 vs. 7.6 ± 6.2 kg, P = 0.001). Suboptimal glycemia was associated with non-European ethnicity, prior GDM, 1-h glucose at booking oral glucose tolerance test, and insulin use.CONCLUSIONS: Both early and delayed treatment of early GDM resulted in similar glycemia toward the end of pregnancy. Early treatment was associated with improved glycemia overall.}, issn = {0149-5992} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_marinopouloumaria_2025, title = {Association Between Intellectual Functioning and Autistic Traits in the General Population of Children}, author = {Marinopoulou, Maria and Billstedt, Eva and Wessman, Catrin and Bornehag, Carl-Gustaf and Unenge Hallerbäck, Maria}, year = {2025}, journal = {Child Psychiatry and Human Development}, volume = {56}, number = {1}, pages = {264--275}, doi = {10.1007/s10578-023-01562-5}, url = {1775478}, language = {eng}, publisher = {Springer}, keywords = {autistic traits; behavioural problems; intellectual functioning; wechsler scales}, abstract = {Autistic traits are continuously distributed in the general population. The associations between autistic traits and intellectual functioning and/or behavioural difficulties, and the impact of intellectual functioning on behavioural difficulties are unclear. The study aims to describe the distribution of autistic traits in a population-based cross-sectional sample of children. Further aims are to examine the association between intellectual functioning and autistic traits, and between autistic traits and behavioural difficulties. Wechsler scales and ratings of autistic traits and behavioural problems in 874 children aged 7-9 years in the Swedish Environmental Longitudinal Mother and Child, Asthma and Allergy (SELMA) study were assessed. We found a continuous distribution of autistic traits. Intellectual functioning was negatively associated with autistic traits but not with behavioural difficulties. Behavioural difficulties were associated with autistic traits.}, issn = {0009-398X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zhoumengping_2025, title = {Association between parental psychiatric conditions and offspring psychiatric, behavioral, and psychosocial outcomes : A Swedish population-based children-of-monozygotic twins study}, author = {Zhou, Mengping and Larsson, Henrik and D'Onofrio, Brian M. and Landén, Mikael and Kuja-Halkola, Ralf and Chang, Zheng and Brikell, Isabell and Lichtenstein, Paul and Pettersson, Erik}, year = {2025}, journal = {PLoS Medicine}, volume = {22}, number = {10}, doi = {10.1371/journal.pmed.1004784}, url = {2008097}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {BACKGROUND: Mental health problems tend to run in families, with studies showing transdiagnostic associations across generations. Nevertheless, if these associations were attributable to unmeasured familial (either environmental or genetic) factors that influence both generations, then treating the parental conditions would not break the intergenerational transmission. This study aims to investigate the associations between parental psychiatric conditions and offspring psychiatric, behavioral, and psychosocial outcomes, after controlling for unmeasured familial factors shared by offspring of monozygotic (MZ) twin parents (i.e., cousins).METHODS AND FINDINGS: We conducted a children-of-MZ twins study that consisted of 15,603 individuals (born to 7,742 MZ twin parents) born in Sweden between 1970 and 2000, and followed them from their date of birth to the date of the outcome or December 31, 2020, when the offspring were between 21 and 51 years old. The exposures were whether the MZ twin parents were diagnosed with any psychiatric condition, any internalizing condition, or any externalizing condition. The outcomes included register-based psychiatric conditions, behavioral problems, suicide, and psychosocial problems in the offspring. We performed stratified Cox regression for time-to-event outcomes and conditional logistic regression for binary outcomes to compare offspring exposed to an MZ twin parent with psychiatric conditions against their unexposed cousins. We adjusted for the highest parental educational level, maternal and paternal age at childbirth, offspring birth year, offspring sex, and psychiatric diagnosis of the nontwin parent. Offspring of parents with any parental psychiatric condition, internalizing condition, or externalizing condition had significantly higher probabilities for all the psychiatric, behavioral, and psychosocial outcomes, with hazard ratios (HRs) ranging from 1.34 (95% confidence interval [CI] [1.21, 1.49]; p < 0.001) to 2.53 (95% CI [1.96, 3.26]; p < 0.001) for time-to-event outcomes and odds ratios ranging from 1.33 (95% CI [1.17, 1.52]; p < 0.001) to 1.87 (95% CI [1.63, 2.14]; p < 0.001) for binary outcomes. Although these associations attenuated when comparing differentially exposed cousins whose parents were MZ twins (20 out of 27 associations were no longer statistically significant within cousin pairs), associations between broad spectra remained statistically significant. Specifically, across the main analysis and several sensitivity analyses, statistically significant within-twin-family associations remained between any parental psychiatric condition and any offspring psychiatric condition (HR = 1.28, 95% CI [1.13, 1.44]; p < 0.001), between parental internalizing conditions and any offspring psychiatric condition (HR = 1.26, 95% CI [1.09, 1.45]; p = 0.002), and between parental externalizing conditions and any offspring psychiatric condition (HR = 1.27, 95% CI [1.08, 1.51]; p = 0.005). The main limitations of this study were unmeasured confounders not shared by cousins, the lack of diagnostic data from primary care, and limited statistical power for some specific clustered outcomes.CONCLUSIONS: Although the intergenerational transmission between parental psychiatric conditions and offspring psychiatric, behavioral, and psychosocial outcomes appeared partially attributable to unmeasured familial (environmental or genetic) factors that influenced both generations, there was also evidence of either nonshared factors or direct causal effects. If the latter, then treating parental psychiatric conditions would reduce the risk of psychiatric vulnerability in offspring.}, issn = {1549-1277} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_arslaniketina_2025, title = {Association Between Physiological Significance and Vulnerable Plaque Characteristics in Patients With Myocardial Infarction : A Prospect II Substudy}, author = {Arslani, Ketina and Engstrøm, Thomas and Maeng, Michael and Kjøller-Hansen, Lars and Maehara, Akiko and Zhou, Zhipeng and Ben-Yehuda, Ori and Bøtker, Hans Erik and Matsumura, Mitsuaki and Mintz, Gary S. and Fröbert, Ole and Persson, Jonas and Wiseth, Rune and Larsen, Alf I. and Jensen, Lisette O. and Nordrehaug, Jan E. and Bleie, Øyvind and Omerovic, Elmir and Held, Claes and James, Stefan K. and Ali, Ziad A. and Erlinge, David and Stone, Gregg W.}, year = {2025}, journal = {JACC Cardiovascular Imaging}, volume = {18}, number = {6}, pages = {696--706}, doi = {10.1016/j.jcmg.2024.11.002}, url = {1940309}, language = {eng}, publisher = {Elsevier}, keywords = {acute myocardial infarction; coronary physiology; intravascular imaging; vulnerable plaque}, abstract = {BACKGROUND: Hemodynamically obstructive coronary plaques may contain more vulnerable plaque characteristics than nonobstructive lesions. OBJECTIVES: The authors aimed to assess whether pressure-wire-based physiologic indices in nonculprit lesions are associated with vulnerable plaque characteristics.METHODS: In the PROSPECT II study, patients with recent myocardial infarction underwent coronary angiography and culprit lesion percutaneous coronary intervention plus combined near-infrared spectroscopy and intravascular ultrasound assessment of all 3 coronary arteries. Instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements were performed in intermediate lesions with angiographic stenosis >40%.RESULTS: Among 898 patients, 319 angiographically intermediate lesions in 275 patients had matched intravascular ultrasound/near-infrared spectroscopy and FFR/iFR measurements; 96 (30.1%) lesions were physiologically significant (FFR ≤0.80 or iFR ≤0.89) and 223 (69.9%) were not. Physiologically significant lesions, compared with those that were not, more likely had a minimal lumen area ≤4.0 mm2 (96.9% vs 83.9%), plaque burden ≥70% (92.7% vs 71.3%) and maximum lipid core burden index in any 4 mm segment of the lesion ≥324.7 (57.0% vs 45.4%). By multivariable analysis, lesion location in the left anterior descending artery, small minimal lumen area, and larger plaque burden were independently associated with physiologic significance, whereas maximum lipid core burden index in any 4 mm segment of the lesion was not.CONCLUSIONS: In patients with recent myocardial infarction, angiographically intermediate but physiologically significant coronary lesions were more likely to have high-risk vulnerable plaque features compared with nonphysiologically significant stenoses. However, coronary lesions without physiological significance also had a moderate-to-high prevalence of high-risk plaque characteristics, which may explain the residual risk associated with conservative noninterventional management of these lesions. (Providing Regional Observations to Study Predictors of Events in the Coronary Tree II [PROSPECT II]; NCT02171065).}, issn = {1936-878X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nilssonkonrad_2025, title = {Association between quality of care indicators and clinical outcomes in patients undergoing transcatheter aortic valve implantation : insights from SWEDEHEART}, author = {Nilsson, Konrad and James, Stefan and Backes, Jenny and Götberg, Matthias and Hagström, Henrik and Batra, Gorav}, year = {2025}, journal = {European Heart Journal - Quality of Care and Clinical Outcomes}, doi = {10.1093/ehjqcco/qcaf146}, url = {2018411}, language = {eng}, publisher = {Oxford University Press}, keywords = {transcatheter aortic valve implantation; cardiovascular outcomes; implementation; mortality; quality indicators; quality of care}, abstract = {BACKGROUND AND AIMS: The European Society of Cardiology (ESC) has developed quality indicators (QIs) specifically for evaluating the care and outcomes for patients undergoing transcatheter aortic valve implantation (TAVI). The aim of this study was to evaluate TAVI care in all patients undergoing such procedures in Sweden using the ESC 2023 QIs for TAVI.METHODS: We used the Swedish Transcatheter Cardiac Intervention Registry to identify all TAVI procedures performed in Swedish centres (n=8) between 2008-2021.RESULTS: 8524 patients (median 82 years, 52.8% male) were included. In total, 24 (88.8%) of the 27 QIs could be captured from the available registry data. The attainment levels were generally high (median 97.8%, interquartile range [IQR] 91.3-100%) with small variations in attainment levels between centres. The greatest variations were observed in the QIs related to patients undergoing TAVI through transfemoral route (median 90.3%, IQR 85.6-96.9%), and in the proportion undergoing transfemoral TAVI without general anaesthesia (median 87.6%, IQR 57.1-94.4%). In total, 80% of the QIs were associated with one-year all-cause mortality, and 85% with one-year cardiovascular mortality. The QIs with greatest impact on one-year mortality were the absence of coronary obstruction (adjusted HR 0.12; 95% CI 0.07-0.22), in-hospital stroke (adjusted HR 0.25; 95% CI 0.18-0.33) and no new dialysis (adjusted HR 0.25; 95% CI 0.15-0.41).CONCLUSION: In this study, the majority of the QIs were associated with both all-cause and cardiovascular mortality. Hence, the ESC 2023 QIs for TAVI may serve as a valuable tool for evaluating TAVI care, benchmarking performance, and improving patient outcomes.}, issn = {2058-5225} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kahlmeterbrandelljenny_2025, title = {Association between short-term radiation-induced toxicity and oncological outcomes in high-risk prostate cancer}, author = {Kahlmeter Brandell, Jenny and Valachis, Antonis and Ugge, Henrik and Smith, Daniel and Johansson, Bengt}, year = {2025}, journal = {Radiotherapy and Oncology}, volume = {206}, number = {Suppl. 1}, pages = {S1896--S1898}, doi = {10.1016/S0167-8140(25)04332-4}, url = {1985564}, language = {eng}, publisher = {Elsevier}, keywords = {prostate cancer; toxicity; radiotherapy}, issn = {0167-8140} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zhoumengping_2025_1, title = {Association between the childhood rearing environment and general and specific psychopathology factors in middle adulthood : a Swedish National High-Risk Home-Reared versus Adopted-Away Sibling Comparison Study}, author = {Zhou, Mengping and Larsson, Henrik and D'Onofrio, Brian M. and Landén, Mikael and Lichtenstein, Paul and Pettersson, Erik}, year = {2025}, journal = {Molecular Psychiatry}, volume = {30}, number = {9}, pages = {4023--4028}, doi = {10.1038/s41380-025-02979-1}, url = {1949304}, language = {eng}, publisher = {Springer Nature}, abstract = {Quasi-experimental and randomized controlled studies suggest that an enriched childhood rearing environment for at-risk individuals can reduce the risk for several psychiatric conditions. However, it remains uncertain if the reduced risk might be attributable to a general psychopathology factor common to all psychiatric conditions, versus specific psychopathology factors unique to only subsets of psychiatric conditions. In an at-risk sample, we estimated the association between an enriched childhood rearing environment and a latent bifactor model that captured both general and several specific psychopathology factors. The sample consisted of 881 full sibships where (a) the biological parents had (at least) one psychiatric diagnosis, suicide, or crime at any time in their lives, and (b) where (at least) one sibling was adopted away and raised by non-biological parents and (at least) one sibling raised by the biological parents. The exposure was whether a sibling was raised by biological versus adoptive parents. The outcome was a latent bifactor model based on nine conditions, including 7 in- or outpatient psychiatric diagnoses, suicide, and crimes. We recorded these outcomes from the birth of the siblings until the end of 2013, when the siblings were 34-64 years old. We used the marginal between-within model to estimate whether the adopted-away sibling(s) had lower scores on the latent factors. The latent bifactor model based on the nine conditions consisted of one general and three specific (externalizing, internalizing, and psychotic) psychopathology factors. The adopted-away siblings scored 0.27 (95% CI: -0.36, -0.18) standard deviations lower on the latent general psychopathology factor and 0.26 (95% CI: -0.38, -0.14) standard deviations lower on the latent specific externalizing factor, compared to their biological siblings who were raised by the biological parents. This result indicates that although genetics appears important for psychiatric comorbidity, the rearing environment also appears to play a systematic role in influencing the liability toward all mental health conditions among at-risk individuals. Improving the childhood rearing environment in high-risk families could potentially mitigate children's liability toward all psychiatric conditions.}, issn = {1359-4184} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zhaiyinghong_2025_1, title = {Association between the inflammatory potential of diet and chronic renal failure : A cohort study of 163 433 UK Biobank participants}, author = {Zhai, Yinghong and Hu, Fangyuan and Yuan, Lei and Cao, Yang and Ye, Xiaofei and Xue, Chao and Xu, Feng}, year = {2025}, journal = {Nutrition}, volume = {136}, doi = {10.1016/j.nut.2025.112766}, url = {1958435}, language = {eng}, publisher = {Elsevier}, keywords = {chronic renal failure; cohort study; dietary pattern; energy-adjusted dietary inflammatory index; uk biobank}, abstract = {OBJECTIVES: There is some preclinical evidence suggesting a pro-inflammatory diet reduces kidney function. In the present study, we aimed to investigate the association of inflammatory potential of diet with the risk of chronic renal failure (CRF).METHODS: Cox regression models were used to examine the association between the energy-adjusted dietary inflammation index (E-DII) quartiles and CRF adjusting varying degrees of confounders. Restricted cubic spline regression was additionally adopted to determine the association of the continuous E-DII and CRF risk. A series of sensitivity and subgroup analyses were also conducted.RESULTS: A total of 163,433 participants entered the primary analysis. During a mean follow-up period of 12.65 years, incident CRF occurred in 5, 333 participants (3.26%). The E-DII scores was stratified into four quartile groups. In a fully adjusted multivariable model, the adjusted hazard ratio for the second, third, and highest quartiles of E-DII intake was 1.12 (95% confidence interval [CI]: 1.04-1.21), 1.21 (95% CI: 1.12-1.31), and 1.23 (95% CI: 1.14-1.33), respectively, compared with the lowest quartile. Trend test indicated a statistically significant increasing trend with increasing E-DII quartiles (P < 0.0001). Similarly, restricted cubic spline regression displayed a positive association of continuous E-DII with CRF, wherein higher scores were linked to an elevated risk of CRF. Results of sensitivity analyses demonstrated consistent findings.CONCLUSIONS: Diet with higher proinflammatory potential was linked to an increased risk of CRF. Implementing measures to limit the intake of pro-inflammatory foods or promoting the adoption of an anti-inflammatory dietary pattern could potentially reduce the occurrence of CRF.}, issn = {0899-9007} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_xukuo_2025, title = {Association between trait mindfulness and self-efficacy in sports-disadvantaged college students in China : the chain mediating role of exercise motivation and persistence}, author = {Xu, Kuo and Zhu, Lin and Li, Yun and Cao, Yang and Zhang, Guodong}, year = {2025}, journal = {Frontiers in Psychology}, volume = {16}, doi = {10.3389/fpsyg.2025.1636692}, url = {2004451}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {chain mediation effect; exercise motivation; exercise persistence; self-efficacy; sports-disadvantaged college students; trait mindfulness}, abstract = {OBJECTIVE: This study investigates the effect of trait mindfulness on self-efficacy in sports-disadvantaged Chinese college students, focusing on the sequential mediating roles of exercise motivation and persistence, to inform interventions that enhance physical activity and psychological well-being.METHOD: A randomly selected sample of 600 sports-disadvantaged college students in China was surveyed, yielding 588 valid responses (male = 296, 50.3%; female = 292, 49.7%). Participants ranged in age from 18 to 23 years (M = 20.06, SD = 1.44). Among them, 45.1% reported smoking and 58.8% reported drinking. The assessment instruments included the Trait Mindfulness Scale, the Exercise Motivation Scale, the Self-Efficacy Scale, and the Exercise Persistence Scale. Data were analyzed using SPSS 26.0 and the PROCESS macro (version 4.1). RESULTS: Significant correlations were identified among trait mindfulness, self-efficacy (r = 0.581, p < 0.01), exercise motivation (r = 0.585, p < 0.01), and exercise persistence (r = 0.545, p < 0.01) within the group of sports-disadvantaged college students. Exercise motivation was significant correlated with both exercise persistence (r = 0.592, p < 0.01) and self-efficacy (r = 0.679, p < 0.01). Exercise persistence also showed a significant correlation with self-efficacy (r = 0.639, p < 0.01). In the effect of trait mindfulness on self-efficacy among sports-disadvantaged college students, both exercise motivation (β = 0.224, 95% confidence interval (CI): [0.176, 0.277]) and exercise persistence (β = 0.100, 95% CI [0.067, 0.136]) demonstrated significant mediating effects. Furthermore, exercise motivation and exercise persistence exhibited a significant chain mediating effect in the influence of trait mindfulness on self-efficacy (β = 0.072, 95% CI [0.050, 0.099]).CONCLUSION: This study offers critical theoretical insights into the interplay between trait mindfulness, exercise behavior, and self-efficacy among sports-disadvantaged college students. It provides a foundation for developing targeted interventions and practical guidance for universities in enhancing sports education, optimizing resource allocation, and establishing psychological support systems. By addressing the unique needs of this population, institutions can foster greater physical engagement and psychological well-being, thereby advancing overall student health.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hedberggraffjenny_2025, title = {Association between upper limb clinical tests and accelerometry metrics for arm use in daily life in children with unilateral cerebral palsy}, author = {Hedberg Graff, Jenny and Bezuidenhout, Lucian and Krumlinde-Sundholm, Lena and Hallgren, Jenny and Moulaee Conradsson, David and Hagströmer, Maria}, year = {2025}, journal = {Disability and Rehabilitation}, volume = {47}, number = {9}, pages = {2436--2442}, doi = {10.1080/09638288.2024.2393801}, url = {1893247}, language = {eng}, publisher = {Taylor & Francis}, keywords = {adolescents; asymmetry index; cerebral palsy; children; cross-sectional; daily living; movement sensor; physical activity; upper limb}, abstract = {PURPOSE: To evaluate the association between upper-limb (UL) clinical tests and UL accelerometry-derived metrics in children with unilateral Cerebral Palsy (CP). METHODS: In this cross-sectional study, twenty children with unilateral CP and Manual Ability Classification System level I-III were included. Outcomes of the Assisting Hand Assessment, Box and Block-Test and accelerometry metrics were collected in the clinical setting and in daily life. UL asymmetry index (i.e., the ratio between the well-functioning UL and the affected UL use) was evaluated in different physical activity levels and relative use of UL was evaluated during daily living. Spearman's correlation was used to determine the association between UL clinical tests and accelerometry metrics in a clinical setting and in daily life.RESULTS: The strongest negative association was between the Assisting Hand Assessment units and accelerometry metrics during the sedentary time in daily life (rs = -0.64). The asymmetries between ULs were highest during the child's sedentary time (asymmetry index: 45.15) compared to when the child was in light (asymmetry index: 23.97) or higher intensity physical activity (asymmetry index: 13.39). The children used both ULs simultaneously for 44% of the time during daily life. CONCLUSION: Accelerometry metrics may provide additional objective information to clinical tests by quantifying the amount of UL movements and the amount of asymmetry between the upper limbs in daily life.}, issn = {0963-8288} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mohsenishahin_2025, title = {Association between whole blood versus balanced component therapy and survival in isolated severe traumatic brain injury}, author = {Mohseni, Shahin and Forssten, Maximilian Peter and Trivedi, Dhanisha and Büki, Andras and Cao, Yang and Mohammad Ismail, Ahmad and Ribeiro, Marcelo A. F. and Sarani, Babak}, year = {2025}, journal = {Trauma surgery & acute care open}, volume = {10}, number = {2}, doi = {10.1136/tsaco-2023-001312}, url = {1960669}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {whole blood; outcomes; transfusion; traumatic brain injury}, abstract = {BACKGROUND: Whole blood transfusion (WBT) is associated with improved hemostasis and possibly mortality in patients with hemorrhagic shock after injury but there are no studies in patients with isolated severe traumatic brain injury (TBI). The objective of this investigation was to compare outcomes of balanced component therapy (BCT) versus WBT in patients with an isolated severe TBI.METHODS: Adult patients (≥18 years) registered in the Trauma Quality Improvement Program (2016-2019) who suffered a blunt isolated severe TBI (head Abbreviated Injury Score ≥3 in the head and ≤1 in the remaining body regions) and who received a BCT (1-2:1 packed red blood cell (PRBC):fresh frozen plasma and 1-2:1 PRBC:platelets) or WBT were eligible for inclusion. Patients were matched, based on the transfusion received, using propensity score matching. The primary outcome of interest was in-hospital mortality.RESULTS: A total of 217 patients received either WBT (n=82) or BCT (n=135). After propensity score matching, 50 matched pairs were analyzed. The rate of in-hospital mortality was significantly lower in the WBT compared with BCT group (43.1% vs 66.7%, p=0.025) corresponding to a relative risk (RR) reduction of 35% in in-hospital mortality (RR (CI 95%): 0.65 (0.43 to 0.97)). However, in subgroup analyses comparing those who were managed surgically and conservatively, this association only remained significant among patients who underwent neurosurgical intervention.CONCLUSIONS: WBT in patients with severe isolated TBI is associated with better survival compared with BCT in patients who require neurosurgical intervention. Further investigation into this finding using an appropriately powered, prospective study design is warranted.LEVEL OF EVIDENCE: Level III, therapeutic.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_whitehousedanielp_2025, title = {Association of Blood-Based Biomarkers and 6-Month Patient-Reported Outcomes in Patients With Mild TBI : A CENTER-TBI Analysis}, author = {Whitehouse, Daniel P. and Wilson, Lindsay and Czeiter, Endre and Büki, Andras and Wang, Kevin K. W. and von Steinbüchel, Nicole and Zeldovich, Marina and Steyerberg, Ewout and Maas, Andrew I. R. and Menon, David K. and Newcombe, Virginia F. J.}, year = {2025}, journal = {Neurology}, volume = {104}, number = {1}, doi = {10.1212/WNL.0000000000210040}, url = {1920405}, language = {eng}, publisher = {Wolters Kluwer}, abstract = {BACKGROUND AND OBJECTIVES: There is seemingly contradictory evidence concerning relationships between day-of-injury biomarkers and outcomes after mild traumatic brain injury (mTBI). To address this issue, we examined the association between a panel of biomarkers and multidimensional TBI outcomes.METHODS: Participants with mTBI (Glasgow coma scores [GCSs] 13-15) were selected from Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury, a European observational study recruiting patients with TBI with indication for brain CT and presentation within 24 hours. Exclusion criteria for this secondary analysis were age younger than 16 years, incomplete biomarker panel, death, or no recorded outcomes. Participants were separated into 2 groups, CT-negative and CT-positive. Multivariable binary logistic regression was used to assess the relation between the log biomarker level (glial fibrillary acidic protein [GFAP], neurofilament light [NfL], neuron-specific enolase [NSE], S100 calcium-binding protein B [S100B], tau, ubiquitin C-terminal hydrolase L1 [UCH-L1]) and dichotomized 6-month outcomes (functional outcomes [GOSE score <8], health-related quality of life [HRQoL; Quality of Life after Brain Injury-Overall Scale (QOLIBRI-OS) score <52, Short-Form 12-Item Survey version 2 Mental Component Summary (SF12v2 MCS) score <40, Short-Form 12-Item Survey version 2 Physical Component Summary (SF12v2 PCS) score <40], persistent postconcussion symptoms [Rivermead Post-Concussion Symptoms Questionnaire score ≥16], anxiety disorder [Generalized Anxiety Disorder-7 (GAD-7) score ≥8], depression [Patient Health Questionnaire-9 (PHQ-9) score ≥10], and post-traumatic stress disorder [PTSD Checklist for DSM-5 (PCL-5) score ≥33]).RESULTS: A total of 1,589 participants (865 CT-negative, 724 CT-positive) were included (77% GCS 15, median age 52 years, 66% male). Higher biomarker levels were associated with a GOSE score <8: CT-negative: S100B (odds ratio [OR] 1.78, 95% CI 1.43-2.23) and UCH-L1 (OR 1.16, 95% CI 1.01-1.33); CT-positive: GFAP (OR 1.22, 95% CI 1.11-1.36), NfL (OR 1.30, 95% CI 1.11-1.52), S100B (OR 1.51, 95% CI 1.23-1.86), tau (OR 1.36, 95% CI 1.17-1.59), and UCH-L1 (OR 1.34, 95% CI 1.17-1.53). In CT-positive participants, positive association was seen between NfL (OR 1.3, 95% CI 1.06-1.60) and UCH-L1 (OR 1.28, 95% CI 1.07-1.54) with QOLIBRI-OS; S100B (OR 1.32, 95% CI 1.02-1.70) with SF12v2 PCS; and NSE (OR 1.52, 95% CI 1.06-2.18) and UCH-L1 (OR 1.21, 95% CI 1.01-1.46) with the GAD-7. However, in CT-negative participants only, negative associations were seen between GFAP and impairment on the QOLIBRI-OS (OR 0.76, 95% CI 0.66-0.88), SF12v2 MCS (OR 0.71, 95% CI 0.61-0.82), SF12v2 PCS (OR 0.79, 95% CI 0.68-0.91), GAD-7 (OR 0.80, 0.68-0.95), PHQ-9 (OR 0.80, 95% CI 0.68-0.93), and PCL-5 (OR 0.80, 95% CI 0.66-0.97). DISCUSSION: Participants with higher biomarker levels had greater odds of impaired functional recovery. However, in CT-negative participants, higher GFAP concentrations were associated with better HRQoL and less impaired mental health. Further exploration is required of the patient phenotypes that may explain the relationships observed in this analysis.}, issn = {0028-3878} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fessper_2025, title = {Association of Circulating Inflammatory Biomarker Levels and Toxicity in Patients Undergoing Pelvic Radiation for Cancer : A Critical Review}, author = {Fessé, Per and Svensson, Per-Arne and Zackrisson, Björn and Valdman, Alexander and Fransson, Per and Grankvist, Kjell and Kristensen, Ingrid and Langegård, Ulrica and Ohlsson-Nevo, Emma and Sjövall, Katarina and Åkeflo, Linda and Ahlberg, Karin}, year = {2025}, journal = {Advances in Radiation Oncology}, volume = {10}, number = {6}, doi = {10.1016/j.adro.2025.101766}, url = {1958682}, language = {eng}, publisher = {Elsevier}, abstract = {Purpose: Radiation therapy (RT) causes tissue damage and inflammation. Because cytokines play a key role in such processes, their expression levels can be an indicator of cell and tissue toxicity. This critical review aims to explore whether levels of circulating inflammatory biomarkers in peripheral blood are associated with proton-or photon-based therapy in the pelvic area and how these levels vary over time. Further, we investigated whether these levels can be linked to radiation dose, the incidence of toxicity, and changes in toxicity over time.Methods and Materials: A literature search was conducted in PubMed to find studies involving comparative cohorts of pelvic irradiated patients with cancer. Studies reporting on the association of markers in peripheral blood with inflammatory processes and/ or toxicity were included.Results: We found evidence of associations between changes in inflammatory cytokine levels and the total cumulative dose-volume together with RT-induced toxicity in patients with cancer treated with pelvic RT. Common patient-reported outcomes demonstrate an association between radiation toxicity (eg, genitourinary toxicity) and circulating inflammatory biomarker levels.Conclusions: This review highlights that the total cumulative dose and irradiated tissue volume are the primary drivers of RT-induced biomarker expression, influencing both early and late toxicity outcomes. The diversity in RT techniques, total dose, and number of treatment sessions across studies likely contributes to the variation in observed results. Circulating cytokine and biomarker levels in the blood can provide valuable monitoring and predictive insights for patients undergoing proton-or photon-based RT of the pelvis. Biomarker analysis in the context of RT offers clinical value by enabling personalized treatment by helping predict which patients are higher risk for certain toxicities, guiding clinicians in tailoring treatment, optimizing supportive care, and adjusting RT plans. This approach could improve patient outcomes and quality of life by reducing long-term complications from radiation exposure.}, issn = {2452-1094} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_carlssontorkel_2025, title = {Association of cumulative early medical events and neurodevelopmental conditions through a common latent factor : A population-based twin study}, author = {Carlsson, Torkel and Larsson, Henrik and Lundström, Sebastian and Bölte, Sven and Taylor, Mark J.}, year = {2025}, journal = {JCPP Advances}, doi = {10.1002/jcv2.70069}, url = {2014829}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {cumulative environmental effect; early medical events; latent factor; neurodevelopmental conditions; twin study}, abstract = {Background: The cumulative effect of early medical events has been shown to be associated with autism. It is unclear whether this effect is specific to autism or if it is associated to other neurodevelopmental conditions (NDCs) as well.Methods: We established a registry-linked population-based twin cohort of 10,254 pairs within the child and adolescent twin study in Sweden. Participants were evaluated for symptoms of autism, attention deficit hyperactivity disorder, tics, and learning difficulties at age 9. Three early medical events previously associated with autism, beyond familial confounding (low birth weight, congenital malformations, and perinatal respiratory stress), were summed up creating an individual cumulative exposure load. Confirmatory Factor Analysis was performed on the measure of NDCs and a standardized common latent NDC factor was regressed on level of cumulative exposure.Results: Cumulative exposure to early medical events was associated with a non-linear increase in the common latent NDC factor, ss = 0.12 (95% CI, 0.07-0.17) for exposure level 1, ss = 0.25 (0.17-0.33) for exposure level 2, and ss = 0.62 (0.34-0.90) for exposure level 3. In a monozygotic twin difference analysis, with familial confounding being fully accounted for, the whole exposure effect was captured by the common factor, with residual associations fully attenuated for all four NDC outcomes, at all levels of cumulative exposure.Conclusion: The result suggests a possibly causal environmental pathway. The cumulative effect of early medical events previously associated with autism, are not specific for autism, but rather associated with NDCs in a broad sense.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_angerskraftlingjenny_2025, title = {Association of health literacy and general self-efficacy with emergency department visits for unclear abdominal pain after bariatric surgery}, author = {Angerås-Kraftling, Jenny and Jaensson, Maria and Dahlberg, Karuna and Stenberg, Erik}, year = {2025}, journal = {Langenbeck's archives of surgery (Print)}, volume = {410}, number = {1}, doi = {10.1007/s00423-025-03736-2}, url = {1959104}, language = {eng}, publisher = {Springer}, keywords = {adverse outcome; bariatric surgery; emergency room visits; general self efficacy; health literacy; obesity}, abstract = {INTRODUCTION: Emergency department visits are common following bariatric surgery and may be partially preventable. Health literacy and general self-efficacy are factors that may influence health-seeking behaviors in these patients. This study aimed to assess whether health literacy and general self-efficacy are associated with an increased frequency of emergency department visits after bariatric surgery.METHODS: Patients who underwent bariatric surgery at a single hospital from 2018 to 2020 were evaluated for their health literacy and general self-efficacy levels before surgery. Data on emergency department visits within the patient's residential region were evaluated over a three-year period, with repeated emergency department visits for abdominal pain as the primary outcome.RESULTS: During the follow-up period, 69 of 231 patients (29.9%) had at least one emergency department visit for abdominal pain, and 20 patients (8.7%) had three or more visits. Inadequate functional health literacy (OR 5.56, 95% CI 1.80-17.19, p = 0.003) and inadequate communicative and critical health literacy (OR 10.48, 95% CI 3.13-35.08, p < 0.001) were both significantly associated with an increased risk of repeated emergency department visits over the three-year period. No significant association was found between low general self-efficacy and the frequency of emergency department visits.CONCLUSIONS: Inadequate health literacy is associated with an increased risk of repeated emergency department visits for abdominal pain following bariatric surgery.}, issn = {1435-2443} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sunjiangwei_2025, title = {Association of histologic and clinical activity with major adverse cardiovascular events in patients with inflammatory bowel disease : A cohort study}, author = {Sun, Jiangwei and Mårild, Karl and Sundström, Johan and Bergman, David and Ebrahimi, Fahim and Halfvarson, Jonas and Olén, Ola and Ludvigsson, Jonas F.}, year = {2025}, journal = {Journal of Internal Medicine}, volume = {298}, number = {6}, pages = {697--710}, doi = {10.1111/joim.70035}, url = {2009112}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {mace; clinical activity; cohort; histologic remission; inflammatory bowel disease}, abstract = {OBJECTIVES: Inflammatory bowel disease (IBD) is a chronic disorder linked to cardiovascular disease (CVD). However, the impact of histologic and clinical activity on this association remains unclear.METHODS: We conducted a nationwide cohort study in Sweden involving 59,168 IBD patients diagnosed in 1969-2017 with histologic evaluation and 91,800 patients diagnosed in 1969-2020 with assessment of clinical activity in 2006-2021. The primary outcome was incident major adverse cardiovascular events (MACE), a composite outcome encompassing ischemic heart disease, stroke, and heart failure. Cox proportional hazards model estimated adjusted hazard ratios (aHRs) of MACE and its subcomponents.RESULTS: We found an increased MACE risk following histologic inflammation (n = 868, incidence rate [IR]: 86.3/10,000 person-years) compared to remission (n = 558, IR = 71.3) (aHR = 1.16 [1.04-1.30]). This excess risk was evident in Crohn's disease (aHR = 1.30 [1.03-1.64]) and ulcerative colitis (aHR = 1.13 [1.01-1.27]). Histologic inflammation was associated with an increased risk of ischemic heart disease, myocardial infarction, ischemic stroke, and heart failure, but not with hemorrhagic stroke. Compared to clinically quiescent IBD, active IBD was associated with an increased MACE risk (IR: 131.4 vs. 93.7; aHR = 1.54 [1.46-1.63]) and all MACE subcomponents. In patients with clinically quiescent IBD, histologic inflammation remained linked to myocardial infarction (aHR = 1.29 [1.06-1.58]) and heart failure (aHR = 1.19 [1.00-1.43]).CONCLUSION: Both histologic and clinical activities of IBD were associated with an increased MACE risk, suggesting that improved disease control may reduce MACE risk in IBD.}, issn = {0954-6820} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nilssonandreas_2025_1, title = {Associations between time spent in sedentary behaviors and metabolic syndrome risk in physically active and inactive European older adults}, author = {Nilsson, Andreas and Limem, Hadil and Santoro, Aurelia and Jurado-Medina, Laura Smeldy and Berendsen, Agnes A. M. and de Groot, Lisette C P G M and Kaluza, Joanna and Januszko, Olga and Jennings, Amy and Fairweather-Tait, Susan and Franceschi, Claudio and Kadi, Fawzi}, year = {2025}, journal = {The Journal of Nutrition, Health & Aging}, volume = {29}, number = {6}, doi = {10.1016/j.jnha.2025.100544}, url = {1946747}, language = {eng}, publisher = {Elsevier}, keywords = {aging; healthy diet; metabolic syndrome; physical activity; sedentary time}, abstract = {Objectives: To determine how clustered metabolic risk based on a validated continuous metabolic syndrome risk score is associated with objectively assessed time in sedentary behaviors (SB) in physically active and inactive older adults, while considering adherence to healthy eating habits.Design: Cross-sectional study.Setting and participants: The study comprises 871 community-dwelling older adults (age 65-79 years) recruited from four European countries.Measurements: Daily times spent in SB and physical activity (PA) were assessed by accelerometers (Actigraph GT3X) for a week. Waist circumference, triglycerides, HDL-cholesterol, mean arterial blood pressure, fasting glucose and insulin were determined, and a continuous metabolic syndrome risk score (cMSy) was generated using principal component analysis. Healthy eating habits were assessed by food record. General linear models stratified by adherence to PA guidelines (active/inactive) were used to examine differences in cMSy across tertiles of time in SB (Low, Medium, High) with adjustment for covariates, including healthy eating habits.Results: A significantly (p < 0.05) lower cMSy was observed among older adults in the low SB tertile compared to medium and high SB tertiles, with no difference between the latter tertiles. The favorable effect of low amounts of SB on cMSy was indicated in both active and inactive groups, and regardless of healthy eating habits. Further, being active was related to a more favorable cMSy across all SB tertiles.Conclusion: Low amounts of time spent in SB are related to a lower metabolic syndrome risk regardless of adherence to PA guidelines and healthy eating habits in older adults, supporting guidelines targeting limited amounts of SB alongside engagement in moderate-to-vigorous PA for promotion of metabolic health.}, issn = {1279-7707} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_huahkan_2025, title = {Associations between working memory, mentalizing skill and well-being in young adults with hearing loss}, author = {Hua, Håkan and Mäki-Torkko, Elina and Holmer, Emil}, year = {2025}, journal = {Discover Psychology}, volume = {5}, number = {1}, doi = {10.1007/s44202-025-00460-2}, url = {2006820}, language = {eng}, publisher = {Springer}, keywords = {well-being; quality of life; hearing loss; mentalizing; working memory}, abstract = {Purpose: Research on well-being in emerging adulthood, typically spanning the 20s to early 30s, has received limited attention in individuals with hearing loss. The present study aimed to explore the associations between well-being - operationalized as health-related and general quality of life as well as perceived stress - and age, working memory, and mentalizing, that is, the ability to reason on other person's mental states, in young adults with hearing loss aged 18-35 years, and test whether well-being differed compared to normally-hearing peers.Methods: In this cross-sectional study, participants were assessed on tests of verbal working memory and mentalizing skill and self-reported perceived stress as well as health-related and general well-being. Forty-one participants, 18 with hearing loss and 23 normal hearing, with a mean age of 26 years were recruited to the study.Results: The results suggest that young adults report similar levels of well-being irrespective of hearing status. Working memory and mentalizing abilities did not show an association to well-being in either group. Age was found to be negatively correlated with well-being for participants with hearing loss.Conclusion: The level of well-being might decline in individuals with hearing loss as everyday demands increase with increasing age in early adulthood.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_theodosiougrigorios_2025, title = {Associations of Atopic Dermatitis in Late Adolescence with Occupation, Mental Health, Income from Work and Marital Status : A National Longitudinal Study}, author = {Theodosiou, Grigorios and Sterner, Therese and Hiyoshi, Ayako and Carlberg, Michael and Svensson, Åke and Montgomery, Scott and von Kobyletzki, Laura B.}, year = {2025}, journal = {Acta Dermato-Venereologica}, volume = {105}, doi = {10.2340/actadv.v105.42127}, url = {1927810}, language = {eng}, publisher = {MJS Publishing}, keywords = {atopic dermatitis; quality of life}, abstract = {The main aim of this study was to evaluate longitudinal associations between atopic dermatitis (AD) in late adolescence and occupational socioeconomic group, labour market participation, income from work, and marital status later in adult life. Using Swedish population-based registry data a total of 205,394 men were included, born between 1952 and 1956 in Sweden and who underwent military conscription examination including assessment of atopic dermatitis (AD) and AD severity. The associations between AD and AD severity in late adolescence and labour market participation, income from work, marital status, and medication for anxiety and depression later in adult life were examined. In this study, men with AD in adolescence, especially those with severe AD, more often had a prescription for antidepressants or anxiolytics at the age of 50-57 years (unadjusted HR 1.55, 95% CI 1.32-1.81). Interestingly, despite increased risk of poorer mental health, AD was not found to be associated with a disadvantage in terms of occupational socioeconomic group, income from work, and unemployment benefits. Individuals with mild AD showed a lower risk of holding routine and lower technical jobs compared with men without AD. Persons with AD in late adolescence seem not to differ regarding registered partnerships and marital status compared with those without AD.}, issn = {0001-5555} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_theodosiougrigorios_2025_1, title = {Associations of Atopic Dermatitis in Late Adolescence with Occupation, Mental Health, Income from Work and Marital Status: A National Longitudinal Study}, author = {Theodosiou, Grigorios and Sterner, Therese and Hiyoshi, Ayako and Carlberg, Michael and Svensson, Åke and Montgomery, Scott and von Kobyletzki, Laura B.}, year = {2025}, journal = {Acta Dermato-Venereologica}, volume = {105}, doi = {10.2340/actadv.v105.42127}, url = {2005532}, language = {eng}, publisher = {MJS Publishing}, keywords = {atopic dermatitis; quality of life}, abstract = {The main aim of this study was to evaluate longitudinal associations between atopic dermatitis (AD) in late adolescence and occupational socioeconomic group, labour market participation, income from work, and marital status later in adult life. Using Swedish population-based registry data a total of 205,394 men were included, born between 1952 and 1956 in Sweden and who underwent military conscription examination including assessment of atopic dermatitis (AD) and AD severity. The associations between AD and AD severity in late adolescence and labour market participation, income from work, marital status, and medication for anxiety and depression later in adult life were examined. In this study, men with AD in adolescence, especially those with severe AD, more often had a prescription for antidepressants or anxiolytics at the age of 50-57 years (unadjusted HR 1.55, 95% CI 1.32-1.81). Interestingly, despite increased risk of poorer mental health, AD was not found to be associated with a disadvantage in terms of occupational socioeconomic group, income from work, and unemployment benefits. Individuals with mild AD showed a lower risk of holding routine and lower technical jobs compared with men without AD. Persons with AD in late adolescence seem not to differ regarding registered partnerships and marital status compared with those without AD.}, issn = {0001-5555} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_eliasongabriella_2025, title = {Associations of comorbid heart disease and depression/anxiety with multidimensional breathlessness in COPD - a cross-sectional study}, author = {Eliason, Gabriella and Ekström, Magnus and Montgomery, Scott and Giezeman, Maaike and Hasselgren, Mikael and Janson, Christer and Kisiel, Marta A. and Lisspers, Karin and Nager, Anna and Sandelowsky, Hanna and Ställberg, Björn and Sundh, Josefin}, year = {2025}, journal = {Respiratory Medicine}, volume = {241}, doi = {10.1016/j.rmed.2025.108053}, url = {1948523}, language = {eng}, publisher = {Elsevier}, keywords = {activity-related breathlessness; anxiety; depression; dyspnea; dyspnea dimensions; heart disease}, abstract = {BACKGROUND: Comorbid conditions and breathlessness are associated with poor outcomes in chronic obstructive pulmonary disease (COPD). We evaluated the associations of comorbid heart disease and depression/anxiety with breathlessness in daily life among people with COPD.METHODS: Cross-sectional analysis from the PRAXIS cohort in central Sweden. Data on patient characteristics and the modified Medical Research Council (mMRC) and Dyspnea-12 breathlessness instruments (D-12) were obtained from questionnaires in 2022. Lung function data were collected from record review. Outcome variables were clinically significant breathlessness defined as mMRC≥2 and D-12 total (>2.7), physical (>1.4) and affective (>1.2) scores above published minimal clinical important differences. Associations of heart disease and depression/anxiety with each outcome were analyzed using multivariable Poisson regression adjusted for relevant confounders.RESULTS: In 522 included patients, mMRC >2 was present in 59% and increased D-12 total, physical and affective domain scores in 69%, 74%, and 50%, respectively. Heart disease was independently associated with mMRC (relative risk ratio [95% confidence interval] 1.34 [1.17-1.53]), D12 physical domain (1.12[1.02-1.24]) and D-12 affective domain (1.20[1.02-1.42]). Depression/anxiety was independently associated with increased D-12 affective domain (1.25[1.04-1.49]). In addition, previous exacerbations and GOLD stage 3-4 were associated with mMRC and D-12, respectively.CONCLUSION: In COPD, comorbid heart disease is associated with both activity-related breathlessness and with physical and affective domains of breathlessness while depression/anxiety is associated with the affective domain of breathlessness. As the influence of different dimensions of breathlessness may differ according to comorbidity the D-12 instrument adds more information when assessing breathlessness in patients with COPD.}, issn = {0954-6111} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_oomensjuliee_2025, title = {Associations of lifestyle factors with amyloid pathology in persons without dementia}, author = {Oomens, Julie E. and Freund-Levi, Yvonne and Zettergren, Anna}, year = {2025}, journal = {Journal of Alzheimer's Disease}, volume = {108}, number = {3}, doi = {10.1177/13872877251379083}, url = {2014094}, language = {eng}, publisher = {Sage Publications}, keywords = {alzheimer's disease; amyloid; amyloid biomarker study; cerebrospinal fluid; lifestyle; positron emission tomography}, abstract = {Background: The association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood.Objective: The aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology.Methods: For this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology.Results: We included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of participants with NC, 58% were women, 34% were APOE ε4 carrier, and 27% had amyloid pathology. Of participants with MCI, 48% were women, 47% were APOE ε4 carrier, and 57% had amyloid pathology. In NC, cognitively active participants were less likely to have amyloid pathology (OR = 0.77, 95%CI 0.66-0.89, p < 0.001). In MCI, participants who had ever smoked or had sleep problems were less likely to have amyloid pathology (OR = 0.85, 95%CI 0.73-0.99, p = 0.029; OR = 0.62, 95%CI 0.45-0.86, p = 0.004).Conclusions: In NC, cognitive activity was associated with a lower frequency of amyloid pathology. In MCI, favorable lifestyle behaviors were not associated with a lower frequency of amyloid pathology. The results of the current study contribute to the broader evidence base on lifestyle and AD by further characterizing the role of lifestyle behaviors in AD pathology across different clinical stages.}, issn = {1387-2877} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_filispanagiotis_2025, title = {Associations of sarcopenia, sarcopenia components and sarcopenic obesity with cancer incidence : A prospective cohort study of 414,094 participants in UK Biobank}, author = {Filis, Panagiotis and Papagiannopoulos, Christos K. and Markozannes, Georgios and Chalitsios, Christos V. and Zerdes, Ioannis and Valachis, Antonis and Papandreou, Christopher and Christakoudi, Sofia and Tsilidis, Konstantinos K.}, year = {2025}, journal = {International Journal of Cancer}, volume = {157}, number = {7}, pages = {1316--1332}, doi = {10.1002/ijc.35480}, url = {1960012}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {cancer; grip strength; muscle mass; sarcopenia; sarcopenic obesity}, abstract = {Sarcopenia is characterised by low grip strength, muscle quantity or quality, and physical performance. This study investigated the associations of sarcopenia and its components with cancer incidence. A prospective cohort study was conducted utilising data from the UK Biobank. Sarcopenia and its components were defined according to the European Working Group on Sarcopenia in Older People criteria (EWGSOP2 2019). Cox proportional hazard models adjusted for sociodemographic, lifestyle, and health-related factors were performed. Overall, 63,379 out of 414,094 study participants had an incident diagnosis of cancer during a median follow-up of 11.7 years. In total, 32,286 participants had probable sarcopenia and 934 confirmed/severe sarcopenia at recruitment. Combined probable, confirmed, and severe sarcopenia was associated with a higher risk of liver (hazard ratio [HR] = 1.65, 95% confidence interval [CI]: 1.17-2.33), haematological (HR = 1.22, 95% CI: 1.01-1.46), and colorectal cancer (HR = 1.21, 95% CI: 1.04-1.41) in males, but not in females. The components of sarcopenia were associated with a higher risk of several cancers, including low grip strength (with liver, haematological and colorectal cancer in males), low muscle mass index (oesophageal in females and oral cancer in males), and slow walking pace (liver and lung in males, lung and overall cancer in females). Compared to participants with non-sarcopenic obesity, those with sarcopenic obesity had a higher risk of colorectal cancer in males (HR = 1.31, 95% CI: 1.03-1.68). Our study suggests that sarcopenia, sarcopenia components, and sarcopenic obesity can be associated with risk for several cancers, mainly of the gastrointestinal tract and in males. Thus, early identification of sarcopenia components may benefit cancer prevention.}, issn = {0020-7136} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_thazhathveettiljishamol_2025, title = {Atherosclerotic Plaque Crystals Induce Endothelial Dysfunction}, author = {Thazhathveettil, Jishamol and Gomez, Sherin Aloysius and Olaoseeji, Deborah and Wu, Rongrong and Sirsjö, Allan and Paramel Varghese, Geena}, year = {2025}, journal = {International Journal of Molecular Sciences}, volume = {26}, number = {19}, doi = {10.3390/ijms26199758}, url = {2006873}, language = {eng}, publisher = {MDPI}, keywords = {atherosclerosis; cholesterol crystal (cc); endothelial dysfunction; monosodium urate (msu); neutrophil extracellular traps (nets)}, abstract = {Endothelial dysfunction is an early driver of atherosclerosis, yet the direct impact of endogenous crystals such as cholesterol crystals and monosodium urate on endothelial activation remains incompletely understood. In this study, we examine how crystalline stimuli modulate human umbilical vein endothelial cells by assessing inflammatory signaling, mitochondrial respiration, and neutrophil recruitment. Using dose- and time-controlled experiments, we show that CC and MSU are internalized by endothelial cells, activating NF-κB and STAT3 signaling pathways and inducing a robust pro-inflammatory cytokine profile. Notably, CC caused marked mitochondrial dysfunction, evidenced by impaired respiratory capacity and loss of membrane potential, revealing a novel bioenergetic vulnerability in endothelial cells. Both direct crystal stimulation and exposure to crystal-primed conditioned media triggered endothelial adhesion molecule expression and promoted neutrophil adhesion, indicating that soluble mediators released upon crystal stimulation can propagate vascular inflammation. These findings demonstrate that crystalline stimuli are potent vascular danger signals capable of driving endothelial inflammation, mitochondrial impairment, and immune cell engagement, which are hallmarks of early atherogenesis. By elucidating these multifaceted endothelial responses, this study provides important mechanistic insights into how crystal-induced signals may contribute to vascular dysfunction and the early stages of atherogenesis.}, issn = {1661-6596} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_wickbomanders_2025, title = {Atrial Fibrillation : Ablation, revascularization, and risk}, author = {Wickbom, Anders}, year = {2025}, url = {1961703}, language = {eng}, publisher = {Örebro University}, keywords = {atrial fibrillation; cabg; pci; af burden; cumulative incidence; long-standing persistent af; minimally invasive ablation}, abstract = {Atrial fibrillation (AF) is associated with an increased risk of stroke, heart failure, and cardiovascular death. Ablation therapy can reduce AF symptoms, arrhythmia burden and mortality, and is performed endovascularly or surgically. Coronary revascularization involve surgical or endovascular techniques. New-onset AF is more commonly reported following surgery, but systematic heart rhythm monitoring strategies are rare. This thesis aimed to investigate the short- and long-term outcomes of totally endoscopic surgical ablation, as well as the short- and long-term incidence, risk factors, and burden of AF after cardiac revascularization.Study I was a randomized controlled trial comparing totally endoscopic epicardial box lesion ablation of the left atrium to medical therapy in patients with long-standing persistent AF (LSPAF). At 1 year, 80% of ablated patients were in sinus rhythm (SR) without the need for antiarrhythmic drugs. Ablation improved physical working capacity, left ventricular systolic function, and self-reported quality of life. Studies II, III, and IV were prospective cohort studies conducted in a real-world population of patients undergoing coronary artery bypass graft (CABG) or per-cutaneous coronary intervention (PCI). A systematic in-hospital and outpatient arrhythmia detection strategy was employed to determine the short-term (30-day) and long-term (24-month) cumulative incidence of new-onset AF. New-onset AF was common after CABG, with most events occurring within the first 30 days, whereas it was rare after PCI, with an even distribution over the 24 months. Undergoing CABG was a significant risk factor for developing new-onset AF. For patients who underwent CABG and developed postoperative AF, the arrhythmia burden was low during the first postoperative year.Study V was a retrospective cohort study investigating the long-term rhythm out-come of the patients from Study I. At a mean follow-up of 9 years, most patients were in AF. The mean time for freedom from AF after totally endoscopic box lesion ablation for LSPAF was 23 months.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_doehnerwolfram_2025, title = {Atrial fibrillation burden in clinical practice, research, and technology development : a clinical consensus statement of the European Society of Cardiology Council on Stroke and the European Heart Rhythm Association}, author = {Doehner, Wolfram and Boriani, Giuseppe and Potpara, Tatjana and Blomström-Lundqvist, Carina and Passman, Rod and Sposato, Luciano A. and Dobrev, Dobromir and Freedman, Ben and Van Gelder, Isabelle C. and Glotzer, Taya V. and Healey, Jeff S. and Karapanayiotides, Theodore and Lip, Gregory Y. H. and Merino, Jose Luis and Ntaios, George and Schnabel, Renate B. and Svendsen, Jesper H. and Svennberg, Emma and Wachter, Rolf and Haeusler, Karl Georg and Camm, A. John}, year = {2025}, journal = {Europace}, volume = {27}, number = {3}, doi = {10.1093/europace/euaf019}, url = {1944255}, language = {eng}, publisher = {Oxford University Press}, keywords = {af burden; atrial fibrillation; clinical outcome; ecg monitoring; heart failure; mortality; quality of life; stroke}, abstract = {Atrial fibrillation (AF) is one of the most common cardiac diseases and a complicating comorbidity for multiple associated diseases. Many clinical decisions regarding AF are currently based on the binary recognition of AF being present or absent with the categorical appraisal of AF as continued or intermittent. Assessment of AF in clinical trials is largely limited to the time to (first) detection of an AF episode. Substantial evidence shows, however, that the quantitative characteristic of intermittent AF has a relevant impact on symptoms, onset, and progression of AF and AF-related outcomes, including mortality. Atrial fibrillation burden is increasingly recognized as a suitable quantitative measure of intermittent AF that provides an estimate of risk attributable to AF, the efficacy of antiarrhythmic treatment, and the need for oral anticoagulation. However, the diversity of assessment methods and the lack of a consistent definition of AF burden prevent a wider clinical applicability and validation of actionable thresholds of AF burden. To facilitate progress in this field, the AF burden Consensus Group, an international and multidisciplinary collaboration, proposes a unified definition of AF burden. Based on current evidence and using a modified Delphi technique, consensus statements were attained on the four main areas describing AF burden: Defining the characteristics of AF burden, the recording principles, the clinical relevance in major clinical conditions, and implementation as an outcome in the clinic and in clinical trials. According to this consensus, AF burden is defined as the proportion of time spent in AF expressed as a percentage of the recording time, undertaken during a specified monitoring duration. A pivotal requirement for validity and comparability of AF burden assessment is a continuous or near-continuous duration of monitoring that needs to be reported together with the AF burden assessment. This proposed unified definition of AF burden applies independent of comorbidities and outcomes. However, the disease-specific actionable thresholds of AF burden need to be defined according to the targeted clinical outcomes in specific populations. The duration of the longest episode of uninterrupted AF expressed as a time duration should also be reported when appropriate. A unified definition of AF burden will allow for comparability of clinical study data to expand evidence and to establish actionable thresholds of AF burden in various clinical conditions. This proposed definition of AF burden will support risk evaluation and clinical treatment decisions in AF-related disease. It will further promote the development of clinical trials studying the clinical relevance of intermittent AF. A unified approach on AF burden will finally inform the technology development of heart rhythm monitoring towards validated technology to meet clinical needs.}, issn = {1099-5129} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_berghandreas_2025, title = {Att beforska barns rättigheter : Några metodologiska reflektioner}, author = {Bergh, Andreas and Lerwall, Lotta}, year = {2025}, url = {2028593}, language = {swe} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_petterssonsa_2025, title = {Att ha ett eget djur och att vara ett : Representationer av barns och djurs relationer i filmen Tjorven, Båtsman och Moses​}, author = {Pettersson, Åsa}, year = {2025}, journal = {Linköping Electronic Conference Proceedings}, volume = {206}, pages = {13--21}, doi = {10.3384/ecp206.13-22}, url = {2032330}, language = {swe}, publisher = {Linköping University Electronic Press}, keywords = {barn- och djurrelationer; barnfilm; barndomssociologi; astrid lindgren; saltkråkan}, abstract = {Artikeln fokuserar på barn och djurs relationer till varandra i den svenska klassiska barnfilmen Tjorven, Båtsman och Moses (1964). Den utgår från mediestudier, barndomssociologi och djurstudier för att studera hur representationer av barns och djurs relationer formas av föreställningar och av funktioner i filmens narrativ. Med inspiration från visuell diskursanalys visas den mångfasettering av representationer av barns och djurs relationer som filmen erbjuder. Både barn och djur innehar huvudroller, visar egen handlingskraft och utvecklas som karaktärer genom filmen. Föreställningar om både barn och djur används som viktiga byggstenar i narrativet. En aspekt av barn-djur-relationen som tydliggörs är hur viktigt det är för barnen att ha ett eget djur. Även djuren behöver bevisa sig som personligheter med omsorg och tillgivenhet för barnen för att de ska kunna skapa relationer med barn i filmberättelsen. Analysen visar därmed hur relationer byggs upp, mellan vilka barn och vilka djur de formas och hur relationerna även i sin mångfasettering är färgade av snäva föreställningar om hur barn och djur förväntas vara.}, issn = {1650-3686} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_rabelinn_2025, title = {Att lära sig konsumera mindre - tillsammans : Studieplan för studiecirkel}, author = {Rabe, Linn and Boström, Magnus and Callmer, Åsa}, year = {2025}, url = {1989268}, language = {swe}, publisher = {Örebro universitet}, keywords = {klimat; konsumtion; livsstilsförändring; miljö; sociala relationer; transformativt lärande}, file = {https://oru.diva-portal.org/smash/get/diva2:1989268/FULLTEXT01.pdf} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_erikssonmats_2025_3, title = {Att riskkommunicera för krisberedskap : En vägvalsmodell}, author = {Eriksson, Mats}, year = {2025}, url = {1939294}, language = {swe}, publisher = {Örebro universitet}, keywords = {riskkommunikation; kriskommunikation; krisberedskap; kampanjer; hemberedskap; kommuner}, file = {https://oru.diva-portal.org/smash/get/diva2:1939294/FULLTEXT02.pdf} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_frdnsara_2025, title = {Att skapa hållbara och jämställda lekmiljöer i staden}, author = {Frödén, Sara}, year = {2025}, url = {2004984}, language = {swe}, publisher = {Örebro kommun / Örebro universitet}, keywords = {lekmiljö; lek; jämställdhet; rast; skolgård; skola}, file = {https://oru.diva-portal.org/smash/get/diva2:2004984/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrkvallanders_2025, title = {Att styra mjukt med texter}, author = {Björkvall, Anders and Nyström Höög, Catharina}, year = {2025}, journal = {Klarspråk. Bulletin från Språkrådet}, number = {3}, pages = {2--2}, url = {2002501}, language = {swe}, publisher = {Språkrådet}, keywords = {klarspråk; styrning; text; genre; professionell praktik}, abstract = {Många av dagens myndighetstexter uppfyller högt ställda krav på klarspråk men är ändå svåra att begripa sig på. ”Vad ska jag göra när jag läst den här texten?” frågar sig läsaren. I denna artikel diskuteras vilket jobb som värdegrundstexter och andra texter i arbetslivet gör, alltså relationen mellan texternas form och deras funktioner.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_bageriushenric_2025, title = {Att utveckla elevers förmåga att resonera historiskt : Slutsatser från ett universitetsutvecklande forskningsprojekt i historia}, author = {Bagerius, Henric}, year = {2025}, url = {2009968}, language = {swe}, publisher = {Örebro universitet}, keywords = {history teaching; practice-based research; historical reasoning; historical comparison; historical interpretations; historical perspectives; historical contextualization; historical argumentation; progression models; upper secondary school; history teacher education; historieundervisning; praktikutvecklande forskning; historiskt resonerande; historiska jämförelser; historiska tolkningar; historiska perspektiv; historisk kontextualisering; historisk argumentation; progressionsmodeller; gymnasieskola; lärarutbildning i historia}, abstract = {Den här arbetsrapporten presenterar slutsatserna från Att resonera historiskt, ett under-visningsutvecklande forskningsprojekt inom ramen för den nationella verksamheten ULF (Utbildning, Lärande, Forskning). I projektet har en historiker och fyra ämneslärare i historia tillsammans under tre läsår undersökt olika aspekter av historiskt resonerande i gymnasieskolan och hur undervisningen där kan utformas för att utveckla elevernas förmåga att resonera historiskt. Projektgruppen har också utforskat hur undervisningsutvecklande forskning kan lyftas in i lärarutbildningen som ett sätt att verksamhetsanknyta den högskoleförlagda utbildningen och fördjupa studenternas förståelse av vad ett undersökande arbetssätt i deras framtida profession kan innebära.Projektets kunskapsprodukt är fyra progressionsmodeller som är tänkta att vara en hjälp för ämneslärare när de planerar sin historieundervisning och följer upp sina elevers lärande i historia. Ambitionen har också varit att modellerna ska kunna användas i ämneslärarutbildningen i historia och ge studenterna en idé om hur de framöver kan arbeta för att möjliggöra en mer nyanserad och fördjupad historisk förståelse hos sina elever.;This report presents the conclusions from Att resonera historiskt (Reasoning Historically), a practice-based research project on teaching and learning conducted within the framework of ULF (Education, Learning, Research). Over the course of three academic years, a historian and four upper secondary history teachers have collaboratively examined different aspects of historical reasoning in secondary education and explored how teaching can be designed to support students’ ability to reason historically. The project group has also investigated how practice-based research on teaching and learning can be integrated into teacher education as a way to strengthen the connection between academia and the school practice, thereby deepening student teachers’ understanding of what an inquiry-based approach can mean in their future profession.The project’s main output consists of four progression models intended to support history teachers in planning their instruction and monitoring their students’ learning in history. A further aim has been for these models to be used in history teacher education, providing student teachers with a vision of how they can foster more nuanced and in-depth historical understanding among their future students.}, file = {https://oru.diva-portal.org/smash/get/diva2:2009968/FULLTEXT02.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_moscam_2025, title = {ATTAINMENT OF LLDAS AND DORIS REMISSION DURING ANIFROLUMABTREATMENT : INTERIM 6-MONTH RESULTS FROM A MULTINATIONAL, OBSERVATIONAL, POST-LAUNCH STUDY OF TREATMENT EFFECTIVENESS IN THE REAL WORLD}, author = {Mosca, M. and Amoura, Z. and Weinmann-Menke, J. and Matsos, M. and Parodis, Ioannis and Kielar, D. and Nåtman, J. and Chen, S. and Emmas, C. and Waratani, M.}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {84}, doi = {10.1016/j.ard.2025.05.215}, url = {1985390}, language = {eng}, publisher = {Elsevier}, keywords = {remission; real-world evidence; biological dmard; observational studies/registry}, abstract = {Background: The Anifrolumab Study of Treatment Effectiveness in the Real World (ASTER; NCT05637112), is a multi-national, prospective, observational study assessing the effectiveness of anifrolumab in patients with systemic lupus erythematosus (SLE) in routine clinical practice. Post-hoc analyses of the phase 3 TULIP-1/-2 and long-term extension (LTE) trials showed that, compared with placebo, remission according to the Definition of Remission in SLE (DORIS) and Lupus Low Disease Activity State (LLDAS), is more attainable and sustainable with anifrolumab treatment in addition to standard therapy in patients with SLE, with shorter time to first attainment and longer cumulative time in these states.[1,2] Here, we describe an interim analysis of DORIS remission and LLDAS attainment rates after 6 months of anifrolumab treatment in patients who participated in ASTER.Objectives: To evaluate the effects of anifrolumab treatment on DORIS remission and LLDAS attainment in patients with SLE from the first 6 months of the ASTER study.Methods: Eligible adults with SLE were enrolled at routine clinical visits before the first anifrolumab infusion date (index) and started anifrolumab treatment per the approved country-specific label at study sites. Baseline disease characteristics were collected retrospectively for 1 year prior to index. Data are reported as mean (standard deviation, SD) for time from SLE diagnosis, SLE Disease Activity Index 2000 (SLEDAI-2K), Physician Global Assessment (PGA), and Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) scores, and oral corticosteroid (OCS) daily dosage. Proportions of patients in DORIS remission, LLDAS, and the individual components of each were evaluated during the observed period at baseline and every 3 months up to 6 months in patients with ≥1 anifrolumab infusion; only patients with no missing individual components were included at each timepoint. The observed period was the time from the first anifrolumab infusion to study discontinuation or loss to follow-up. DORIS remission was defined by clinical SLEDAI-2K=0, PGA <0.5, OCS ≤5 mg/day prednisone or equivalent, and standard maintenance immunosuppressant or biologic dosing, if any. LLDAS was defined by all of the following criteria: SLEDAI-2K ≤4 with no activity in major organ systems, no new lupus disease activity compared with the previous assessment, PGA ≤1, OCS ≤7.5 mg/day prednisone or equivalent, and standard maintenance immunosuppressant or biologic dosing, if any.Results: Among the 266 patients in the interim ASTER cohort, mean (SD) time from SLE diagnosis to index was 12.3 (9.6) years. At baseline, mean (SD) scores were SLEDAI-2K=7.4 (4.1), PGA=1.5 (0.6), CLASI activity=6.4 (7.2), and CLASI damage=3.3 (6.4). Among patients with available SDI data, about half (53.0%, n/N=133/251) had a baseline SDI score ≥1. Of the 260 patients with available SLEDAI-2K data, most patients (74.2%, 193/260) had a baseline SLEDAI-2K score <10. Overall, mean (SD) OCS dosage at baseline was 5.7 (8.6) mg/day (>5 mg/day: 28.9%, 77/266; >7.5 mg/day: 23.7%, 63/266); among patients with baseline OCS dosage >0 mg/day (n=144), mean dosage was 10.5 (9.2) mg/day. At baseline, 23.3% of patients (62/266) had prior use of a biologic, 13.2% (35/266) an immunosuppressant, and 30.8% (82/266) received at least one of these medications. Among the patients with no missing data for any DORIS remission components, rates of DORIS remission increased from 1.2% (3/256) at baseline to 10.5% (18/171) at 3 months and 19.0% (15/79) at 6 months after the first anifrolumab infusion (Table 1). Similarly, rates of LLDAS attainment increased from 10.5% (27/256) at baseline to 35.7% (61/171) at 3 months and 36.7% (29/79) at 6 months after the first anifrolumab infusion. Over 6 months of follow-up, the greatest increase in the proportion of patients achieving an individual DORIS component was in the clinical SLEDAI-2K=0 component (baseline: 6.3%, 16/256; 3 months: 36.8%, 63/171; and 6 months: 49.4%, 39/79); the greatest increase among LLDAS components was in the PGA ≤1 component (baseline: 28.5%, 73/256; 3 months: 66.7%, 114/171; and 6 months: 75.9%, 60/79) (Table 1).Conclusion: In ASTER at baseline, rates of DORIS remission and LLDAS were low among patients receiving routine SLE care. Within 6 months of the first anifrolumab infusion, attainment rates for both states substantially increased. Though follow-up data beyond 6 months are needed to determine if these effects can be sustained, these findings suggest that both targets are achievable with anifrolumab treatment in a real-world setting.}, issn = {0003-4967} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_cortesesamuele_2025, title = {Attention-deficit/hyperactivity disorder (ADHD) in adults : evidence base, uncertainties and controversies}, author = {Cortese, Samuele and Bellgrove, Mark A. and Brikell, Isabell and Franke, Barbara and Goodman, David W. and Hartman, Catharina A. and Larsson, Henrik and Levin, Frances R. and Ostinelli, Edoardo G. and Parlatini, Valeria and Ramos-Quiroga, Josep A. and Sibley, Margaret H. and Tomlinson, Anneka and Wilens, Timothy E. and Wong, Ian C. K. and Hovén, Nina and Didier, Jeremy and Correll, Christoph U. and Rohde, Luis A. and Faraone, Stephen V.}, year = {2025}, journal = {World Psychiatry}, volume = {24}, number = {3}, pages = {347--371}, doi = {10.1002/wps.21374}, url = {1997904}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {adult attention‐deficit/hyperactivity disorder; controversies; descriptive validity; diagnosis; etiology; management; people with lived experience; predictive validity}, abstract = {Attention-deficit/hyperactivity disorder (ADHD) was once thought to be solely a childhood condition. Now it is well established that it can persist into adulthood, with an estimated worldwide prevalence of around 2.5%. Additionally, up to 70% of individuals with childhood-onset ADHD continue to experience impairing symptoms as adults, even if they no longer meet the criteria for a formal diagnosis. The validity of adult ADHD initially faced strong criticism. Today, empirical research supports its descriptive validity (identifying characteristic signs and symptoms), predictive validity (concerning specific outcomes, courses, and responses to treatment), and concurrent validity (evidence related to its underlying causes and biological mechanisms). Despite this progress, unresolved questions and ongoing debates about adult ADHD persist. This paper summarizes current empirical evidence, alongside uncertainties and controversies, regarding the definition, epidemiology, diagnosis, etiology, neurobiology, and management of ADHD in adults. Crucially, we also include perspectives from individuals with lived experience of this condition, highlighting their views on unmet needs and priorities for improving care. Key uncertainties and controversies on adult ADHD include: a) the possibility of late-onset ADHD; b) the significance of emotional dysregulation as a core symptom; c) the definition and characterization of functional impairment; d) the persistence of comorbid psychiatric and somatic conditions after accounting for confounders; e) the relevance of executive dysfunction in the definition of the condition; f) the use of objective diagnostic measures; g) the long-term effects of treatments; and h) the role of non-pharmacological interventions. Further research on adult ADHD is urgently needed. Funding for studies on this condition lags behind that for childhood ADHD and other mental disorders in adulthood. Hopefully, efforts by clinicians, researchers and other stakeholders will ultimately help ensure that adults with ADHD are better understood, supported, and empowered to thrive.}, issn = {1723-8617} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_yaohonghui_2025, title = {Attention-deficit/hyperactivity disorder and cardiometabolic risk profile in patients with acute myocardial infarction : data from the SWEDEHEART registry}, author = {Yao, Honghui and Brikell, Isabell and Larsson, Henrik and Li, Lin and Du Rietz, Ebba and Hartman, Catharina A. and Jernberg, Tomas and Andell, Pontus and Chang, Zheng}, year = {2025}, journal = {European Journal of Preventive Cardiology}, doi = {10.1093/eurjpc/zwaf151}, url = {1951777}, language = {eng}, publisher = {Oxford University Press}, keywords = {attention deficit hyperactivity disorder; mace; mortality; myocardial infarction; risk profile}, abstract = {AIMS: Attention-deficit/hyperactivity disorder (ADHD) is increasingly diagnosed in adults and is associated with cardiometabolic diseases. Yet, the associations between ADHD and cardiometabolic risk profile, participation in non-pharmacological interventions, and long-term outcomes in patients with myocardial infarction (MI) remain unclear.METHODS AND RESULTS: This observational study involved patients from the SWEDEHEART (the Swedish Web-system for Enhancement and Development of Evidence-based Care in Heart Disease Evaluated According to Recommended Therapy) registry, aged 18-74 years old, diagnosed with their first acute MI from 2006 to 2020. We assessed the associations between ADHD and cardiometabolic risk profile (clinical parameters, disease histories, and behavioural factors), engagement in guideline-recommended non-pharmacological interventions, recurrent cardiovascular events, and mortality. We analysed adults with MI with ADHD (n = 582) and without ADHD (n = 2704). Most clinical parameters and disease histories did not differ significantly between groups. However, patients with ADHD had higher risks of smoking (risk ratio, RR = 1.53; 95% confidence interval 1.36-1.71] and snus use (RR = 1.65; 1.36-1.99), were less likely to participate in follow-up evaluations (RR = 0.87; 0.79-0.96), or to stop smoking after MI (RR = 0.76; 0.63-0.91). They had a higher rate of all-cause mortality (hazard ratio = 2.02; 1.05-3.88) after discharge, but not recurrent cardiovascular events.CONCLUSION: Adults with MI and ADHD present similar cardiometabolic risk profiles but poorer lifestyle behaviours, lower engagement in recommended interventions, and higher mortality compared with those without ADHD, underscoring the need for integrated cardiology care with psychiatric services.}, issn = {2047-4873} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jordahlhenrik_2025, title = {Attractiveness and preferences for redistribution in non-Western countries}, author = {Jordahl, Henrik and Mavisakalyan, Astghik and Poutvaara, Panu}, year = {2025}, journal = {European Journal of Political Economy}, volume = {90}, number = {Part B}, doi = {10.1016/j.ejpoleco.2025.102772}, url = {2012059}, language = {eng}, publisher = {Elsevier}, keywords = {attractiveness; beauty; inequality; redistribution; gender differences}, abstract = {This paper examines the link between physical attractiveness and individual support for income redistribution in a non-Western context. Using nationally representative survey data from the South Caucasus, we find that more attractive individuals are less supportive of redistribution, consistent with findings from Western settings. However, the negative correlation is only present among women. This gender pattern contrasts with previous studies, which have predominantly found a stronger correlation among men. Consequently, gender-specific relationships between attractiveness and redistributive preferences seem to be better explained by cultural influences than by universal claims grounded in evolutionary psychology.}, issn = {0176-2680} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_volgstenulrik_2025, title = {Attuning to Play : From Being Seized by Music to Ways of Being-With}, author = {Volgsten, Ulrik}, year = {2025}, journal = {International Review of the Aesthetics and Sociology of Music}, volume = {66}, number = {2}, pages = {215--234}, url = {2002545}, language = {eng}, publisher = {Hrvatsko Muzikolosko Drustvo}, keywords = {play; resonance; affect attunement; vitality affect; recognition; being-with; gadamer; stern}, abstract = {In this paper we sketch a hermeneutical-phenomenological framework building on two distinct but complementary bodies of theory. The first is an aesthetics of play, as developed by philosopher Hans-Georg Gadamer. The second is a theory of vitality affect and affect attunement, as put forth by developmental psychologist Daniel Stern. This will account for how music may not only seize a listener in the moment of play, but also for what it is that both seizes and becomes seized, in a mimetic movement ultimately describable as attunement through vitality affect – thus providing an important key to what makes music exclusive and irreplaceable to many listeners.}, issn = {0351-5796}, file = {https://oru.diva-portal.org/smash/get/diva2:2002545/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vanbellejono_2025, title = {Audiovisual fiction and democracy : A systematic literature review}, author = {Van Belle, Jono and Aitaki, Georgia and Jansson, Maria}, year = {2025}, journal = {Nordicom Review}, volume = {46}, number = {s1}, pages = {55--83}, doi = {10.2478/nor-2025-0008}, url = {1959002}, language = {eng}, publisher = {Nordicom}, keywords = {critical interpretative synthesis; politics; television; audiences; democracy; nordic noir}, abstract = {Polarisation and an increased blending of politics and fiction in various media outlets makes audiovisual storytelling and politics increasingly intertwined. This article presents the first systematic literature review of what we know about the relationship between audiovisual fiction and democracy. We investigate how articles conceptualise 1) democracy and 2) the relationships between politics, fiction, and audiences. We find that most articles implicitly assume a taken-for-granted liberal representative democracy, rather than elaborate on particularities. Further, extant research tends to find that fiction relates to democracy primarily by the way it may impact political opinions, attitudes, and behaviour under certain circumstances, or by contributing to constructing identities and belongings that can either enhance or diminish democratic values. Finally, some research elaborates on how cross-media flows makes fictional elements part of democracy movements.}, issn = {1403-1108}, file = {https://oru.diva-portal.org/smash/get/diva2:1959002/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_brauerjohn_2025, title = {Austerity through rescaling and layering in the Swedish welfare state}, author = {Brauer, John}, year = {2025}, journal = {Geografiska Annaler. Series B, Human Geography}, volume = {107}, number = {3}, pages = {292--306}, doi = {10.1080/04353684.2024.2336045}, url = {1848189}, language = {eng}, publisher = {Routledge}, keywords = {austerity; rescaling; layering; welfare; universalism}, abstract = {It is often claimed that Nordic welfare states are characterized by universalism – however, such claims ignore the persistent duality of social service provision in these states between the central state and municipalities, the lowest political-administrative level. This paper investigates the Swedish welfare state, by looking at the rescaling of welfare services from national to municipal level and its (negative) effects on both municipalities and service users. The aim is to expand the understanding of austerity measures and their local impact by analyzing the transformation processes of responsibilities between national and municipal institutions in the Swedish welfare system based on rescaling and policy layering. Two cases of rescaling are analyzed through public reports and statistics: transfer from national sickness insurance to municipal social assistance, and personal assistance for people with disabilities. The two cases illustrate the vulnerability of Swedish municipalities, in cases of national austerity measures, as the municipalities have the ‘ultimate responsibility’ for marginalized groups such as unemployed people and people with disabilities. Given the differences between municipalities, in terms of factors such as size and economic situation, and the extensive discretion of municipalities in determining services, rescaling to municipalities increases inequalities between people living in Sweden based on municipal residence.}, issn = {0435-3684}, file = {https://oru.diva-portal.org/smash/get/diva2:1848189/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jendlejohanh_2025, title = {Automated basal insulin delivery versus multiple daily injections in type 1 diabetes : results from a randomized parallel controlled trial}, author = {Jendle, Johan H. and Garg, Satish K. and Thivolet, Charles and Weinstock, Ruth S. and Hirsch, Irl B. and Evans, Mark and Griffin, Kurt J. and Philis-Tsimikas, Athena and Wheeler, Benjamin J. and Kipnes, Mark S. and Carlson, Anders L. and Buckingham, Bruce A. and Bhargava, Anuj and Bode, Bruce W. and Lawson, Margaret L. and Criego, Amy B. and McGill, Janet B. and Reed, John Chip H and Prakasam, Gnanagurudasan and Grunberger, George and Girelli, Angela and Martinez-Brocca, María Asunción and Christiansen, Mark P. and de Bock, Martin I. and Kudva, Yogish C. and Lee, Scott W. and Yovanovich, Caroline and Shin, John J. and Cordero, Toni L. and McVean, Jennifer J. F. and Vigersky, Robert A.}, year = {2025}, journal = {Frontiers in Endocrinology}, volume = {16}, doi = {10.3389/fendo.2025.1716587}, url = {2025932}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {hba1c; adult; automated insulin delivery; diabetes treatment satisfaction; pediatric; time below range; time in range; type 1 diabetes}, abstract = {INTRODUCTION: This study evaluated 6-month effectiveness and safety of automated insulin delivery (AID) in comparison with multiple daily injections (MDI) in pediatric and adult type 1 diabetes (T1D).MATERIALS AND METHODS: Individuals with T1D, aged 2-80 years, were enrolled across 32 international centers (in the United States, Europe, Canada, and New Zealand) and randomized 1:1 to AID intervention (MiniMed™ 670G or 770G system) or MDI with or without continuous glucose monitoring. Primary endpoints were change in mean HbA1c for participants with a baseline HbA1c >8.0% (Group 1) and percentage of time spent below 70 mg/dL (%TBR <70 mg/dL [<3.9 mmol/L]) for participants with baseline HbA1c ≤8.0% (Group 2), to show superiority of AID intervention versus MDI. Safety endpoints including rates of severe hypoglycemia and diabetic ketoacidosis (DKA), and difference in diabetes treatment satisfaction score were assessed.RESULTS: For Group 1, N = 56 participants (aged 29.4 ± 17.0 years) were randomized to AID intervention and N = 54 participants (aged 36.8 ± 19.6 years) were randomized to MDI. For Group 2, N = 73 (aged 37.4 ± 21.0 years) and N = 69 (aged 39.2 ± 19.3 years), respectively, were randomized to AID and MDI. Change in HbA1c (mean [95% CI] difference of -0.7% [-1.1, -0.3], P = 0.0002) and difference in %TBR <70 mg/dL (4.8% [-6.4, -3.1], P<0.001) favored AID intervention versus MDI. Rates of severe hypoglycemia (AID: 1.82/100 patient-years) and DKA (MDI: 3.52/100 patient-years) were low and met preestablished success criteria for safety.DISCUSSION: This large, international, multicenter randomized controlled trial demonstrates safety of the MiniMed™ 670G/770G systems. AID significantly improved HbA1c and time spent in hypoglycemia when compared with MDI, in both youth and adults living with T1D.CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/, identifier NCT02748018.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_huangzhen_2025, title = {Automated evaluation of imaginary time strong coupling diagrams by sum-of-exponentials hybridization fitting}, author = {Huang, Zhen and Golez, Denis and Strand, Hugo U. R. and Kaye, Jason}, year = {2025}, journal = {SciPost Physics}, volume = {19}, number = {5}, doi = {10.21468/SciPostPhys.19.5.121}, url = {2016310}, language = {eng}, publisher = {SciPost Foundation}, abstract = {We present an efficient separation of variables algorithm for the evaluation of imaginary time Feynman diagrams appearing in the bold pseudo-particle strong coupling expansion of the Anderson impurity model. The algorithm uses a fitting method based on AAA rational approximation and numerical optimization to obtain a sum-of-exponentials expansion of the hybridization function, which is then used to decompose the diagrams. A diagrammatic formulation of the algorithm leads to an automated procedure for diagrams of arbitrary order and topology. We also present methods of stabilizing the self-consistent solution of the pseudo-particle Dyson equation. The result is a low-cost and high-order accurate impurity solver for quantum embedding methods using general multi-orbital hybridization functions at low temperatures, appropriate for low-tointermediate expansion orders. In addition to other benchmark examples, we use our solver to perform a dynamical mean-field theory study of a minimal model of the strongly correlated compound Ca2RuO4, describing the anti-ferromagnetic transition and the inand out-of-plane anisotropy induced by spin-orbit coupling.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kofodlinettemarie_2025, title = {Automated Oxygen Delivery in Home Setting for Patients with COPD on Long-Term Oxygen Therapy - A Randomized Crossover Feasibility Trial}, author = {Kofod, Linette Marie and Hansen, Ejvind Frausing and Kristensen, Morten Tange and Brocki, Barbara Cristina and Westerdahl, Elisabeth}, year = {2025}, journal = {The International Journal of Chronic Obstructive Pulmonary Disease}, volume = {20}, pages = {3697--3712}, doi = {10.2147/COPD.S546748}, url = {2016192}, language = {eng}, publisher = {Dove Medical Press}, keywords = {activities of daily living; automated oxygen titration; closed-loop; long-term oxygen therapy; oxygen saturation; technology}, abstract = {RATIONALE: Patients with COPD on long-term oxygen therapy (LTOT) have an unmet need for oxygen adjustments during sleep, rest, and activity, documented by continuous monitoring of oxygen saturation (SpO2). While emerging technology enables automated adjustments, its feasibility in home settings remains uncertain. This randomized crossover trial evaluated the feasibility and preliminary effects of continuous automated oxygen titration at home.METHODS: The intervention period involved four days of automated oxygen titration targeting a SpO2 of 90-94% using a Bluetooth-connected electronic device and wrist pulse oximeter, forming a closed-loop system. Oxygen flow (0.9-6.8 L/min) was continuously adjusted based on SpO2. During the control period, patients received their usual fixed dose oxygen. Feasibility was defined as time with automated titration, time within target SpO2 and patient acceptance. Additionally, health status was measured using the Clinical COPD Questionnaire (CCQ, minimal important difference 0.4).RESULTS: Twelve patients (8 men, mean (SD) age 72.9 (5.5) years) on LTOT with an oxygen dose of 2.0 (0.8) L/min were included. Each patient provided more than 217,000 paired SpO2 and oxygen flow data points. Oxygen flow was automatically adjusted for a median of 77 h (IQR 68.0-84.3), covering 83% of the time. Time within target SpO2 increased from 52% (42-63) to 86% (75-90) during the intervention. All patients used the full available flow range. The CCQ score improved by 0.74 (0.47) points; p < 0.001.CONCLUSION: Automated oxygen titration is feasible in the home setting, achieving more time with normoxia, but it required a wide flow range and continuous SpO2 monitoring. The patients reported a clinically relevant reductions in COPD symptoms measured with CCQ. The clinical importance of controlling SpO2 needs to be examined in a larger study.}, issn = {1176-9106} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_farooquimuhammadsaad_2025, title = {AutoSHARC : Feedback Driven Explainable Intrusion Detection with SHAP-Guided Post-Hoc Retraining for QoS Sensitive IoT Networks}, author = {Farooqui, Muhammad Saad and Khattak, Aizaz Ahmad and Awaji, Bakri Hossain and Alturki, Nazik and Alnazzawi, Noha and Hanif, Muhammad and Khan, Muhammad Shahbaz}, year = {2025}, journal = {CMES - Computer Modeling in Engineering & Sciences}, volume = {145}, number = {3}, pages = {4395--4439}, doi = {10.32604/cmes.2025.072023}, url = {2022744}, language = {eng}, publisher = {Tech Science Press}, keywords = {qos preservation; intelligent programmable networks; intrusion detection; iot security; feature selection; shap explainability; boruta; lightgbm; explainable deep learning; resource-efficient ai}, abstract = {Quality of Service (QoS) assurance in programmable IoT and 5G networks is increasingly threatened by cyberattacks such as Distributed Denial of Service (DDoS), spoofing, and botnet intrusions. This paper presents AutoSHARC, a feedback-driven, explainable intrusion detection framework that integrates Boruta and LightGBM-SHAP feature selection with a lightweight CNN-Attention-GRU classifier. AutoSHARC employs a two-stage feature selection pipeline to identify the most informative features from high-dimensional IoT traffic and reduces 46 features to 30 highly informative ones, followed by post-hoc SHAP-guided retraining to refine feature importance, forming a feedback loop where only the most impactful attributes are reused to retrain the model. This iterative refinement reduces computational overhead, accelerates detection latency, and improves transparency. Evaluated on the CIC IoT 2023 dataset, AutoSHARC achieves 98.98% accuracy, 98.9% F1-score, and strong robustness with a Matthews Correlation Coefficient of 0.98 and Cohen's Kappa of 0.98. The final model contains only 531,272 trainable parameters with a compact 2 MB size, enabling real-time deployment on resource-constrained IoT nodes. By combining explainable AI with iterative feature refinement, AutoSHARC provides scalable and trustworthy intrusion detection while preserving key QoS indicators such as latency, throughput, and reliability.}, issn = {1526-1492} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025, title = {Avdrag för utgifter för konsulttjänster – en analys av HFD 2025 ref. 26}, author = {Kristoffersson, Eleonor}, year = {2025}, journal = {Svensk skattetidning}, number = {5}, pages = {526--534}, url = {2031813}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, issn = {0346-2218} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_blomstenamanda_2025, title = {Avoidant/restrictive eating in people with and without bowel symptoms in the general population : Prevalence, Clinical Profile and Associated Factors}, author = {Blomsten, Amanda and Trindade, Ines A. and Nybacka, Sanna and Melchior, Chloé and Algera, Joost P. and Weznaver, Cecilia and Störsrud, Stine and Törnblom, Hans and Simrén, Magnus}, year = {2025}, journal = {American Journal of Gastroenterology}, doi = {10.14309/ajg.0000000000003735}, url = {1991591}, language = {eng}, publisher = {Wolters Kluwer}, abstract = {INTRODUCTION: We aimed to investigate the prevalence of avoidant/restrictive eating in individuals with versus without bowel symptoms in the general population, and identify factors associated with avoidant/restrictive eating.METHODS: In this Swedish population-based internet health survey, we included individuals with at least one bowel symptom used to diagnose a functional bowel disorder according to the Rome IV criteria, and an age- and sex-matched control group without bowel symptoms. Cutoffs for the Nine-Item avoidant/restrictive food intake disorder screen (NIAS) was used to determine the prevalence of avoidant/restrictive eating. Demographics and clinical characteristics were assessed using validated questionnaires, and independent factors associated with avoidant/restrictive eating were determined by hierarchical multiple regression analysis.RESULTS: Avoidant/restrictive eating was more common in individuals with bowel symptoms (n=825) compared to controls (n=1806) (22.8% vs 18.2%, p<.001). Individuals with bowel symptoms with avoidant/restrictive eating were more often female, had lower body mass index, more likely to report overlapping functional dyspepsia, reported more severe bowel, psychological and somatic symptoms, shape/weight concerns, and a lower quality of life. Bowel symptom severity emerged as the strongest factor explaining the variability of avoidant/restrictive eating severity.DISCUSSION: Avoidant/restrictive eating is common in individuals with bowel symptoms and associated with a more severe clinical profile, indicating a need to discuss eating behavior with patients. However, avoidant/restrictive eating is also common in individuals in the general population without bowel symptoms.}, issn = {0002-9270} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_devguntannishtha_2025, title = {AWOSE : Probabilistic State Model for Consensus Algorithms' Fuzzing Frameworks}, author = {Devgun, Tannishtha and Kumar, Gulshan and Saha, Rahul and Brighente, Alessandro and Conti, Mauro}, year = {2025}, pages = {955--970}, doi = {10.1145/3708821.3733876}, url = {2018242}, language = {eng}, publisher = {Association for Computing Machinery (ACM)}, keywords = {blockchain; consensus; testing; probability; fuzzing}, abstract = {Fuzzing frameworks allow the detection of code bugs or errors by feeding the code with unconventional inputs. Recently, Ma et al. proposed LOKI (NDSS, 2023), the first fuzzing framework tailored to blockchain consensus protocols [1]. LOKI uses high-frequency messages to model the dynamics of consensus algorithms. However, low-frequency messages are fundamental to the consensus's state evolution. Thus, neglecting them hinders the in-depth exploration of vulnerabilities, leading to missed bugs or critical issues generated by low-frequency messages.In this paper, we propose messAge-aWare hybrid markOved StatE model (AWOSE), a fuzzing frameworkmodeling highandlow-frequency messages to uncover vulnerabilities and bugs in consensus algorithms. AWOSEleverages Markov Chains (MCs) tomodel the general states of the consensus messages while leveraging Hidden Markov Models (HMMs) to model latent or hidden state transitions based on code mutations (as in LOKI) or external factors (e.g., malicious inputs). Such probabilistic state models are beneficial for capturing the uncertain nature of system behaviors, enabling a more realistic and flexible representation of consensus dynamics. AWOSE is the first model to introduce the message context-based state model generation for fuzzing purposes. Via a thorough evaluation, we compare AWOSE with LOKI. Results show that our proposed AWOSE provides 48.3% more accurate states and 83.2% better path coverage. Thanks to AWOSE we were able to uncover new bugs that LOKI did not detect. Our experiments lead to the identification of previously unknown vulnerabilities, currently being evaluated as CVEs.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_zdemirmetin_2025, title = {Backstage stories : Barriers and facilitators in conducting prevention research with immigrant youth and families}, author = {Özdemir, Metin and Amouri, Hasnaa and Amouri, Layan and Juang, Linda and Schachner, Maja and Västhagen, Maja and Altebo Nyathi, Sandra}, year = {2025}, url = {2002072}, language = {eng}, abstract = {This workshop aims to present the barriers and facilitators of conducting prevention research with youth and families from immigrant and refugee backgrounds. Conducting such research involves unique challenges, including language barriers, cultural differences, limited understanding of or different views about research, distrust, and instability in living conditions. These are just a few of the unique challenges that researchers must address to ensure the quality implementation of their research. However, there are limited resources available to guide novice researchers and practitioners in learning from the experiences of others.Experiences from two large-scale projects in different contexts, Germany and Sweden, will form the basis of this workshop. We will present the strategies that were effective in achieving the project goals, as well as the failures and lessons learned. The facilitators include senior researchers, a doctoral student, project assistants who worked on project administration and data collection, and intervention leaders who ran intervention sessions with the participants. Workshop participants will have the opportunity to interact with both senior and junior research staff, who will share firsthand experiences from different phases of project development, implementation, and dissemination.Overall, this workshop is designed to empower novice researchers and practitioners by enhancing their understanding of the challenges, barriers, and facilitators of conducting prevention research with youth and families from immigrant and refugee backgrounds. The program will include interactive group activities to provide hands-on experiences for the participants.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wistrandcamilla_2025, title = {Bacterial air contamination and the protective effect of coverage for sterile surgical goods : A randomized controlled trial}, author = {Wistrand, Camilla and Söderquist, Bo and Friberg, Örjan and Sundqvist, Ann-Sofie}, year = {2025}, journal = {American Journal of Infection Control}, volume = {53}, number = {4}, pages = {467--472}, doi = {10.1016/j.ajic.2024.12.012}, url = {1922566}, language = {eng}, publisher = {Elsevier}, keywords = {bacterial air contamination; infection control; operating room; operation; surgical site infection; time dependent}, abstract = {BACKGROUND: There is limited knowledge regarding how long prepared sterile goods can wait before becoming contaminated. We investigated whether surgical goods could be prepared the day before surgery and kept sterile overnight in the operating room, if protected by sterile covers.METHODS: Sterile surgical goods for open-heart surgeries (n=70) were randomized to preparation on the morning of the operation or on the previous evening. Exposure time was the total time between preparation and use. Primary outcome was bacterial growth reported as colony forming units (cfu), isolated on 840 agar plates. The protocol was registered with ClinicalTrials.gov (NCT05597072).RESULTS: When the agar plates were protected with sterile covers, exposure time had no impact (intervention group: 7 cfu, control group: 17 cfu). Without protection, longer exposure time was associated with more cfu (p=0.016). A total of 499 cfu were isolated, displaying 59 different types of bacteria including 13 resistant Staphylococcus epidermidis, 6 (46%) of which were multidrug resistant.CONCLUSIONS: Sterile goods could wait in the operating room for at least 15 hours before use without increased risk of bacterial air contamination, if protected with sterile covers. However, if the goods were not covered, bacterial air contamination occurred over time.}, issn = {0196-6553} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kornfltisberghelena_2025, title = {Bacterial growth and antimicrobial resistance in urinary Escherichia coli isolates among men with lower UTI in Swedish primary healthcare : retrospective data over a 4 year period}, author = {Kornfält Isberg, Helena and Sundqvist, Martin and Melander, Eva and Beckman, Anders and Hedin, Katarina}, year = {2025}, journal = {JAC - Antimicrobial Resistance}, volume = {7}, number = {1}, doi = {10.1093/jacamr/dlae214}, url = {1926027}, language = {eng}, publisher = {Oxford University Press}, abstract = {BACKGROUND: Escherichia coli, the most common bacterium causing urinary tract infections (UTIs), is increasingly reported as resistant to multiple antibiotics. Swedish surveillance data from hospital and primary health care (PHC) report a 17%-19% prevalence of resistance to ciprofloxacin in E. coli from urine cultures in men over 20 years of age. Surveillance data may include nosocomial infections. However, few studies have described resistance in E. coli in men with community-acquired UTI in PHC. We aimed to describe the microbiological results, including antibiotic resistance in E. coli, in men with lower UTI (LUTI) attending PHC.METHODS: In this retrospective study based on information from electronic medical records, we included patients from 289 PHC centres. For all men aged 18-79 years diagnosed with LUTI in PHC from January 2012 to December 2015, we extracted data on age, UTI diagnosis and results from urine cultures. RESULTS: A total of 17 987 episodes of lower UTI were identified. E. coli was detected in 62% of positive cultures and 63% of detected E. coli isolates were susceptible to all tested antimicrobials. Resistance in E. coli to the first-choice antibiotics pivmecillinam and nitrofurantoin were 2% and 1%, respectively. Resistance to ciprofloxacin was 9%, and to trimethoprim it was 17%.CONCLUSIONS: Resistance levels for ciprofloxacin in E. coli among men with LUTI in PHC were lower than in surveillance data. The results of this study point to the importance of surveillance of resistance in urine samples from patients with LUTI in PHC in order to choose the right empirical antibiotic treatment.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_katawazaiasmatullah_2025, title = {Barbed suture versus preperitoneal ventral patch in medium-size ventral hernia repair : randomized clinical trial}, author = {Katawazai, Asmatullah and Wallin, Göran and Sandblom, Gabriel}, year = {2025}, journal = {BJS Open}, volume = {9}, number = {6}, doi = {10.1093/bjsopen/zraf099}, url = {2010748}, language = {eng}, publisher = {Oxford University Press}, keywords = {epigastric hernia; linea alba; umbilical hernia}, abstract = {BACKGROUND: This study aimed to compare preperitoneal ventral mesh patch with barbed suture in ventral hernia repair, evaluating recurrence rates and complications, and to assess the safety of preperitoneal patch placement.METHODS: In this randomized clinical trial, adult patients undergoing ventral hernia repair at Karlskoga Hospital between 2020 and 2023 were randomized 1 : 1 to either a ventral mesh patch repair group or a non-absorbable barbed suture repair group, blinded to patients and outcome assessors. The primary outcome was recurrence detected at clinical examination and CT verification 1 year after surgery. Pain (measured on a visual analogue scale and using the Ventral Hernia Pain Questionnaire), nausea, and surgical site events (including wound infection, haematoma and seroma) were assessed 4 h, 1 week, 1 month, and 4 years after operation.RESULTS: Of 256 eligible patients, 209 were screened, and 205 were randomized to ventral mesh patch repair (103) or barbed suture repair (102). The hernia recurrence rate at 1 year was lower in the ventral patch repair group (1.9 versus 5.9%), although this was not statistically significant (P = 0.14). The surgical site infection rate at 1 month was significantly lower in the ventral patch group (0.9 versus 6.9%; P = 0.02). At 1 month, the ventral patch repair group had higher 'pain right now' scores on the Ventral Hernia Pain Questionnaire (P = 0.02), although this difference had disappeared by 1 year.CONCLUSION: Preperitoneal ventral hernia patch repair is a safe and effective technique with a recurrence rate not statistically significant from that after barbed suture repair. Although postoperative pain scores at 1 month were higher after ventral patch repair, this difference had disappeared by 1 year.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_katawazaiasmatullah_2025_1, title = {Barbed suture vs preperitoneal ventral patch in medium size ventral hernia repair : a randomised control trial}, author = {Katawazai, Asmatullah and Wallin, Göran and Sandblom, Gabriel}, year = {2025}, journal = {British Journal of Surgery}, volume = {112}, number = {Suppl. 11}, pages = {XI31--XI31}, doi = {10.1093/bjs/znaf149.111}, url = {1992520}, language = {eng}, publisher = {Oxford University Press}, abstract = {Introduction: Aim: To compare preperitoneal ventral mesh patch with barbed suture in ventral hernia repair, evaluating recurrence rates and complications, and to assess the safety and efficacy of standardised preperitoneal patch placement.Methods: In this randomised controlled trial, 205 adult patients undergoing ventral hernia repair were randomised 1:1 to either a ventral mesh patch repair group (n=103) or a 2.0 non-absorbable barbed suture repair group (n=102), blinded to patients and outcome assessors. Primary outcome was recurrence one year after surgery. Pain, nausea, and surgical site events were assessed on four occasions up to one year.Results: 205 patients were randomised to ventral mesh patch repair (n=103) or barbed suture repair (n=102). Hernia recurrence at one year was lower in the ventral patch group (1.9% vs. 5.9%), though not statistically significant (p=0.14). Surgical site infection rate at one month was significantly less in the ventral patch group (0.9% vs. 6.9%; p=0.02). At one month, the ventral patch group had higher "Pain right now" scores on the VHPQ (p=0.02), this difference had disappeared by one year.Discussion: Conclusion: Preperitoneal ventral hernia patch repair is a safe and effective technique that results in a lower recurrence rate (though not statistically significant) than barbed suture. While postoperative pain scores at one month were higher in the patch group, this difference had disappeared by one year.}, issn = {0007-1323} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_vikandermartina_2025, title = {Barn i frigörelsen från våld : Sårbarhet och motstånd i kontexter av mäns våld mot kvinnor}, author = {Vikander, Martina}, year = {2025}, url = {1953750}, language = {swe}, publisher = {Örebro University}, keywords = {ungdomar; våld i nära relation; könsrelaterat våld; riskhantering; skydd; stöd; socialtjänst; polis; familjerätt; patriarkat; makt; feministisk teori}, abstract = {Mäns våld mot kvinnor i nära relation är ett omfattande samhällsproblem. Barn som lever i familjer där fäderna eller styvfäder utövar våld mot barnens mödrar utsätts också för våldet. För att möjliggöra barns och kvinnors frigörelse kan de behöva riskhanteringsåtgärder i form av skydd- och stödinsatser från socialtjänsten eller polisen. För att öka åtgärdernas genomförbarhet behöver både barnens och mödrarnas behov identifieras och beaktas. Syftet med avhandlingen är att fördjupa förståelsen för barn i frigörelsen från våld genom att analysera behovet och genomförbarheten av riskhanteringsåtgärder i kontexter av mäns våld mot kvinnor i nära relation. Avhandlingen bygger på intervjuer med våldsutsatta mödrar och ungdomar, dokumenterade polisförhör med barn och en forskningsöversikt om barns erfarenheter av socialarbetare. De olika materialen har bidragit till att olika aspekter av barns behov har kunnat studerats utifrån flera perspektiv. Resultaten visar att barns behov formas av deras sårbarhet och möjlighet till motstånd. Patriarkala maktordningar kan förstärka sårbarheten och minskar både barnens och mödrarnas möjlighet till frigörelse. Genomförbarheten av riskhanteringsåtgärder kan dock öka genom tillgängliga professionella som har en holistisk förståelse av våld där barns relationella utsatthet inkluderas, samt mödrars och barns möjlighet att bryta med våldsutövaren. Genom att erkänna barns och mödrars relationella sårbarhet och dess koppling till maktstrukturer kan åtgärder breddas för att möjliggöra mer omfattande och inkluderande skydd och stöd. Avhandlingen understryker dock vikten av att riskhantering inte bara handlar om att skydda, utan också om att stärka barns och mödrars förmåga att agera och utmana makten i våldet.}, file = {https://oru.diva-portal.org/smash/get/diva2:1953750/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_thunbergsara_2025_1, title = {Barn på skyddat boende – Vad behöver professionella tänka på?}, author = {Thunberg, Sara}, year = {2025}, url = {2016511}, language = {swe} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025, title = {Barnets och förälderns födelse}, author = {Johansson Wilén, Evelina}, year = {2025}, journal = {Röda rummet}, number = {3-4}, pages = {96--97}, url = {2012465}, language = {swe}, publisher = {Socialistiska partiet}, issn = {1403-3844} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hoffmannsardfabianaa_2025, title = {Baseline intestinal microbiota composition influences response to a real-world dietary fiber intervention}, author = {Hoffmann Sardá, Fabiana A. and Giuntini, Eliana B. and Oliveira, Aline and Souza, Gabriela S. and Prado, Samira and Taddei, Carla R. and Tadini, Carmen C. and Bittinger, Kyle and Bushman, Frederic D. and Menezes, Elizabete W. and Hoffmann, Christian}, year = {2025}, journal = {npj Biofilms and Microbiomes}, volume = {11}, number = {1}, doi = {10.1038/s41522-025-00817-4}, url = {2012133}, language = {eng}, publisher = {Springer Nature}, abstract = {The intestinal microbiota is shaped by fiber-rich ingredients, such as unripe banana flour (UBF), high in resistant starch (RS). We investigated the effects of RS-rich UBF and inulin on gut microbiota and intestinal function in a double-blind, randomized, placebo-controlled pilot trial. Forty-eight healthy adults consumed maltodextrin (control), inulin, or UBF three times weekly for six weeks. Microbiota composition and function were analyzed using 16S rRNA gene sequencing and PICRUSt, alongside fecal short-chain fatty acids, blood biochemistry, and gastrointestinal parameters. We observed two microbiota clusters at baseline, one Prevotella-rich (P) and one Bacteroides-rich (B), with distinct responses to the interventions. Only cluster P subjects consuming UBF showed significant global microbiota shifts (weighted Unifrac Beta diversity, PERMANOVA p = 0.007) and major functional changes (533 KEGG orthologs, FDR < 0.05). Inulin produced modest modulation (19 KOs) on cluster P, and no effects were observed on cluster B. RS-rich UBF modulated gut microbiota in a composition-dependent manner, supporting the potential of microbiota-based stratification to improve dietary fiber interventions.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_bodnarolha_2025, title = {Bayesian Regularization of the Tangency Portfolio}, author = {Bodnar, Olha and Bodnar, Taras and Niklasson, Vilhelm}, year = {2025}, pages = {197--221}, doi = {10.1007/978-3-032-00110-8_9}, url = {2034462}, language = {eng}, publisher = {Springer}, abstract = {In the chapter, two new priors, designed directly for the tangency portfolio weights, are developed. While the first approach is based on the extension of the Laplace prior, the second procedure generalizes the spike and slab prior. The posterior distributions of the tangency portfolio weights under both priors are characterized in terms of stochastic representations. These findings are used to establish exact sampling schemes for drawing samples of tangency portfolio weights from the corresponding posterior distributions, from which both the Bayesian point and interval estimators of the tangency portfolio weights are constructed.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_berggrenniclas_2025, title = {Beauty in Politics}, author = {Berggren, Niclas and Jordahl, Henrik and Poutvaara, Panu}, year = {2025}, pages = {70--80}, url = {1897142}, language = {eng}, publisher = {Edward Elgar Publishing}, keywords = {beauty; appearance; elections; politics; democracy; heuristics}, abstract = {The beauty of political candidates can serve as a heuristic for voters who lack detailed information about competing candidates. Attractive candidates may be perceived as more competent and are often favored, even by those who do not consciously value beauty. Research suggests beauty may influence electoral success through various mechanisms, including enhanced media coverage and greater confidence. While earlier studies primarily relied on observational data, more recent studies have used experimental designs to establish the causal effects of appearance on voting behavior. This chapter reviews the existing literature and explores the implications of candidate appearance for electoral outcomes.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_svenssonprimusrobert_2025, title = {Becoming Swedish pragmatics : comparing the coaching philosophies of Sven-Goran Eriksson and Pia Sundhage}, author = {Svensson Primus, Robert and Svensson, Daniel}, year = {2025}, journal = {Sport Coaching Review}, volume = {14}, number = {1}, pages = {63--83}, doi = {10.1080/21640629.2023.2248847}, url = {1797324}, language = {eng}, publisher = {Routledge}, keywords = {sweden; coaching; football; democratic leadership; professionalisation}, abstract = {Since the dawn of modern sport, Swedish athletes and leaders have made a significant impact in the global sport community, and Swedish scientists and entrepreneurs have contributed to the development of coaching and training. But when it comes to football, Sweden has rather taken influence from others. Two names contradict this relative anonymity - Sven-Goran Eriksson and Pia Sundhage. They both have had long and successful careers which have brought Swedish coaching ideals to an international audience. The purpose of this study is to investigate how their respective coaching philosophies have developed over time and how they have been shaped by education, previous experiences, and influences in the coaches' own lives. The developments of Eriksson's and Sundhage's coaching philosophies are analysed through the lens of theories about scientisation, specialisation and professionalisation. We build on their own publications, as well as interviews and archival sources.}, issn = {2164-0629} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mustelljan_2025, title = {Beginning teachers' descriptions of ball games as pedagogic practice in Swedish physical education}, author = {Mustell, Jan}, year = {2025}, journal = {European Physical Education Review}, volume = {31}, number = {3}, pages = {426--443}, doi = {10.1177/1356336X241280841}, url = {1904346}, language = {eng}, publisher = {Sage Publications}, keywords = {ball games; game-based approaches; beginning teachers; pe practice; bernstein}, abstract = {Teaching approaches in ball games in school physical education (PE) have traditionally focused on technical proficiency. Technical approaches have been criticised for being teacher-centred, exclusive, and lacking meaning. Game-based approaches (GBAs) have been presented as an alternative way to teach ball games. Employing GBAs is, however, not without challenges. Scholars have pointed to teachers' limited content knowledge of games, their poor understanding of GBAs, and cultural expectations of ball games as factors that constrain teachers' work with GBAs. The aim of this article is to provide an understanding of how beginning teachers describe ball games as a pedagogic practice in Swedish PE. Semi-structured interviews were conducted with 12 beginning teachers who had graduated from two physical education teacher education (PETE) institutions. Bernstein's concepts of classification and framing were used to analyse the teachers' descriptions of pedagogic practice. The findings illustrate how the classification of ball games knowledge varies. Some of the beginning teachers aimed to develop pupils' understanding of games while others instead used ball games as a means for developing general movement capability or cooperation. Ball games teaching was characterised by a combination of GBAs and technical approaches. The influence of competitive sport outside of school was seen as a challenge, and the beginning teachers used strong framing and different teaching strategies combined with assessment to manage this challenge. The findings raise questions about ball games education in PETE in relation to specific national contexts.}, issn = {1356-336X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sklivaniotigreenfieldmyrto_2025, title = {Behavioral intervention with task repetition compared to pharmacological intervention with SSRI for enhancement of cognitive control in emotional and non-emotional settings}, author = {Sklivanioti Greenfield, Myrto and Wang, Yanlu and Martinsson, Lina and Li, Tie-Qiang and Msghina, Mussie}, year = {2025}, journal = {Psychopharmacology}, volume = {242}, number = {12}, pages = {2817--2833}, doi = {10.1007/s00213-025-06835-6}, url = {1975333}, language = {eng}, publisher = {Springer}, keywords = {cognitive control; eda; emotion regulation; escitalopram; fnirs; pfc; training}, abstract = {RATIONALE: Cognitive control is crucial for optimal daily functioning and for emotional well-being. Cognitive control has been shown to be modified by experimental manipulations under widely differing experimental conditions, including cognitive training, and pharmacological intervention mainly probing catecholaminergic systems with little focus on the serotonergic system.OBJECTIVES: To explore the role of serotonin on cognitive control in emotional and non-emotional settings.METHODS: Behavioral, electrodermal and prefrontal activity measures were evaluated to compare the effects of single-session task repetition and single-dose serotonergic intervention with escitalopram on cognitive control in healthy participants, using cognitive and emotional Stroop tasks.RESULTS: For cognitive Stroop, task repetition improved performance both 'on-line' within an ongoing task and 'off-line' after a four-hour delay, and escitalopram had no additional effects on this. In emotional Stroop, escitalopram enhanced the practice-related performance gain, starting from the second stimulus of each block. Compared to placebo, escitalopram also significantly reduced overall rate of premature responses. Regarding brain activation, escitalopram significantly reduced prefrontal activity during cognitive and even more so during emotional Stroop task. Lastly, electrodermal response showed significant habituation during cognitive but not emotional Stroop, in an effect that was not significantly modified by escitalopram.CONCLUSIONS: Cognitive control in emotional and non-emotional settings may respond differently to behavioral and pharmacological manipulations. Escitalopram may selectively improve cognitive control in an emotional setting compared to cognitive control in non-emotional settings.}, issn = {0033-3158} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_andrndaniela_2025_1, title = {“Behind Blue Eyes” : The valuation of knowing someone who attempted or died by suicide in Sweden}, author = {Andrén, Daniela}, year = {2025}, url = {2003689}, language = {eng}, publisher = {Örebro University, School of Business}, keywords = {suicide exposure; suicide attempt; life satisfaction; suicide spillover; well-being valuation method; life satisfaction approach; sweden}, abstract = {Advancing the economic understanding of suicide’s externalities, this study uses the well-being valuation method (WVM) to quantify the exposure to suicide, specifically through knowing someone near, family, or friend (NFF) who attempted or died by suicide. First, using data from a survey of Swedish adults, we separately estimate several life satisfaction equations. For each equation, we use the same comparison group of individuals who reported never having been exposed to others’ suicide, and compare them against different groups, each exposed to NFF-related suicide attempts or deaths. We find that income has a statistically significant positive impact on life satisfaction across all equations, and except for the experience of death alone, all other exposures to suicide have a statistically significant negative impact on life satisfaction. Next, we use these estimates to calculate the monetary compensation required to offset the decline in life satisfaction for individuals exposed to a NFF’s suicide attempt or death. The required annual monetary compensation to offset this decline ranges from 6,400 to 9,910 euros, which suggests an economic value for mitigating the negative effects of suicide exposure equivalent to around a median monthly household income. However, our findings should be considered with caution when used to inform healthcare policies and prevention strategies aimed at reducing the spillover effects of exposure to suicide. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_malmquistanna_2025, title = {Being ‘That Token Gay Guy’ : Experiencing Minority Stress in Swedish Workplaces}, author = {Malmquist, Anna and Wurm, Matilda and Ek, Therese and Lönnroth, Rosaline and Lundberg, Tove}, year = {2025}, journal = {Nordic Journal of Working Life Studies}, doi = {10.18291/njwls.163344}, url = {2028090}, language = {eng}, publisher = {Det Kongelige Bibliotek, VIA University College}, keywords = {health; working environment & wellbeing; gender; ethnicity; age and diversity; identity; meaning & culture}, abstract = {Employers in Sweden are mandated to take active measures to prevent discrimination against sexual minorities. While it is important that relevant measures are taken, knowledge is lacking about cisgender lesbian, gay, and bisexual (LGB) people’s minority stress experiences at Swedish workplaces. The present work is based on a thematic analysis of interviews with 53 cisgender LGB participants, focusing on how they experienced and dealt with minority stress experiences at work. Results are drawing on the minority stress model and illustrate experiences of distal minority stress due to a heteronormative work climate. This distal stress led to proximal stressors, such as constantly being on guard. Participants took considerable responsibility for others’ feelings, felt a responsibility to educate on LGBTQ issues, and sometimes engaged in formal policy work to improve workplace conditions. The study points at the importance of shifting the burden of workplace minority stress from individual LGB people to employers.}, file = {https://oru.diva-portal.org/smash/get/diva2:2028090/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gomezalvaro_2025, title = {Belimumab concentrations and immunogenicity in relation to drug effectiveness and safety in SLE within a Swedish real-world setting}, author = {Gomez, Alvaro and Walhelm, Tomas and Loeff, Floris C. and Jönsen, Andreas and Nikolopoulos, Dionysis and van den Broek, Bryan and Bengtsson, Anders A. and de Vries, Annick and Rispens, Theo and Sjöwall, Christopher and Parodis, Ioannis}, year = {2025}, journal = {Rheumatology}, volume = {64}, number = {6}, pages = {3797--3805}, doi = {10.1093/rheumatology/keaf128}, url = {1942606}, language = {eng}, publisher = {Oxford University Press}, keywords = {b cells; b lymphocyte; anti-drug antibodies; belimumab; biologics; immunogenicity; systemic lupus erythematosus; therapeutic monitoring}, abstract = {OBJECTIVE: Studies supporting therapeutic drug monitoring to biopharmaceuticals in systemic lupus erythematosus (SLE) are scarce. We aimed to assess anti-drug antibody (ADA) occurrence in belimumab-treated SLE patients and associations between belimumab concentrations and clinical response, serological outcomes, and adverse events.METHODS: We included 100 patients treated with intravenous belimumab. Clinical data and biological samples were collected at baseline and months 3, 6, 12, and 24. Belimumab levels were determined by quantitative sandwich ELISA, and ADA by an acid-dissociation radioimmunoassay. Clinical activity was evaluated with the SLE disease activity index 2000 (SLEDAI-2K), revised SLE activity measure (SLAM-R), and physician's global assessment (PhGA). Serological markers included C3, C4, and anti-dsDNA. We performed cross-sectional Spearman's rank correlation analyses, and longitudinal analyses using generalised estimating equations.RESULTS: Belimumab concentrations varied widely (median: 25.8; IQR: 20.9-43.5 μg/ml) but were stable over time at the group level. Pre-existing ADA were detected in 2 patients, but no patient developed ADA during follow-up. Belimumab levels moderately correlated with SLEDAI-2K (ρ: -0.37; p= 0.003) and PhGA (ρ: -0.41; p= 0.005) at month 6, while longitudinal analysis revealed a very weak association with SLEDAI-2K (β: -0.10; SE: 0.05; p= 0.031) and a weak association with SLAM-R (β: -0.32; SE: 0.13; p= 0.014). Despite moderate correlations between belimumab levels and serological markers at month 6, there were no associations in longitudinal analysis. There was no relationship between belimumab levels and adverse events.CONCLUSION: Belimumab yielded no immunogenicity. Belimumab levels were modestly associated with clinical activity but not with serological activity or adverse events.}, issn = {1462-0324} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_grossogiorgia_2025, title = {Belimumab efficacy in mucocutaneous lupus erythematosus : a large post-hoc analysis from five phase III clinical trials}, author = {Grosso, Giorgia and Giannopoulou, Nefeli and Tsoi, Alexander and Cetrez, Nursen and Nikolopoulos, Dionysis and Lindblom, Julius and Parodis, Ioannis}, year = {2025}, journal = {Rheumatology}, volume = {64}, number = {7}, pages = {4257--4266}, doi = {10.1093/rheumatology/keaf145}, url = {1946359}, language = {eng}, publisher = {Oxford University Press}, keywords = {belimumab; biologics; skin; systemic lupus erythematosus; therapeutics}, abstract = {OBJECTIVE: To determine the efficacy of belimumab on mucocutaneous manifestations of systemic lupus erythematosus (SLE) in a large integrative analysis.METHODS: Using data from five phase III clinical trials (BLISS-52; BLISS-76; BLISS-NEA; EMBRACE; BLISS-SC; N = 3086), we investigated the effect of belimumab vs placebo on top of standard therapy on inducing improvement in mucocutaneous British Isles Lupus Assessment Group (mcBILAG) and mucocutaneous SLE Disease Activity Index 2000 (mcSLEDAI-2K), and on preventing mcBILAG flares. We employed logistic and Cox regression analysis, adjusting for trial variance.RESULTS: Belimumab was superior to placebo in inducing mcBILAG (week-52 OR: 1.29; 95% CI: 1.07-1.57; p = 0.008) and mcSLEDAI-2K (week-52 OR: 1.37; 95% CI: 1.16-1.62; p < 0.001) improvement, as well as in inducing sustained (≥2 visits, maintained through week 52) mcBILAG (HR: 1.23; 95% CI: 1.07-1.41; p = 0.003) and mcSLEDAI-2K (HR: 1.24; 95% CI: 1.17-1.31; p < 0.001) improvement. These associations held true for patients with SLEDAI-2K ≥10 and positive anti-dsDNA levels at baseline, but not their counter groups. Belimumab prevented mcBILAG flares to a greater extent than placebo in patients with positive anti-dsDNA levels (HR: 0.70; 95% CI: 0.50-0.98; p = 0.035) and with a near-significant separation in patients with baseline SLEDAI-2K ≥10 (HR: 0.71; 95% CI: 0.51-1.00; p = 0.050), whereas no difference was seen in their counter groups.CONCLUSION: Belimumab is superior to placebo in inducing improvement and in preventing flares in the mucocutaneous domain of SLE, especially in patients with high disease activity and in serologically active patients.}, issn = {1462-0324} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_goslingcorentinj_2025, title = {Benefits and harms of ADHD interventions : umbrella review and platform for shared decision making}, author = {Gosling, Corentin J. and Garcia-Argibay, Miguel and De Prisco, Michele and Arrondo, Gonzalo and Ayrolles, Anaël and Antoun, Stéphanie and Caparos, Serge and Catalán, Ana and Ellul, Pierre and Dobrosavljevic, Maja and Farhat, Luis C. and Fico, Giovanna and Eudave, Luis and Groenman, Annabeth P. and Højlund, Mikkel and Jurek, Lucie and Nourredine, Mikail and Oliva, Vincenzo and Parlatini, Valeria and Psyllou, Constantina and Salazar-de-Pablo, Gonzalo and Tomlinson, Anneka and Westwood, Samuel J. and Cipriani, Andrea and Correll, Christoph U. and Yon, Dong Keon and Larsson, Henrik and Ostinelli, Edoardo G. and Shin, Jae Il and Fusar-Poli, Paolo and Ioannidis, John P. A. and Radua, Joaquim and Solmi, Marco and Delorme, Richard and Cortese, Samuele}, year = {2025}, journal = {BMJ (Clinical Research Edition)}, volume = {391}, doi = {10.1136/bmj-2025-085875}, url = {2016938}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, abstract = {OBJECTIVES: To assess the effects of and related evidence certainty of interventions for attention deficit/hyperactivity disorder (ADHD) across an individual's lifespan, and to develop a continuously updated web platform for people with lived experience of ADHD as a method to disseminate living evidence synthesis for shared decision making.DESIGN: Umbrella review and platform for shared decision making. DATA SOURCES: Six databases from inception to 19 January 2025. Study authors were contacted for additional information when necessary.ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Systematic reviews that used meta-analyses of randomised controlled trials were eligible if they compared a drug or non-drug intervention with a passive control in individuals with a diagnosis of ADHD. Primary outcomes were severity of ADHD symptoms, analysed by rater type (clinician-rated, parent-rated, teacher-rated, or self-rated) and time point (short term (12 weeks, or study endpoint), medium term (26 weeks), and long term (52 weeks)),acceptability (participants dropping out for any reason), and tolerability (participants dropping out owing to any side effects). Secondary outcomes included daily functioning, quality of life, comorbid symptoms, and key side effects (decreased sleep and appetite).DATA SYNTHESIS: Eligible meta-analyses were re-estimated with a standardised statistical approach. Methodological quality was assessed using AMSTAR-2. Evidence certainty was evaluated using an algorithmic version of the GRADE framework, adapted for drug and non-drug interventions.RESULTS: 115 of 414 full text articles were deemed eligible and 299 were excluded; the eligible articles comprised 221 unique combinations of participants, interventions, comparators, and outcomes. For each combination, the most recent and methodologically robust meta-analysis was selected for re-estimation, which gave 221 re-estimated meta-analyses in total, derived from 47 meta-analytic reports. In the short term, alpha-2 agonists, amphetamines, atomoxetine, methylphenidate, and viloxazine showed medium to large effect sizes in reducing the severity of ADHD symptoms in children and adolescents, with moderate to high certainty evidence. Methylphenidate showed consistent benefits across raters (standardised mean difference >0.75, 95% confidence interval (CI) 0.56 to 1.03; moderate or high certainty evidence). These interventions showed lower tolerability than the placebo, but this effect was not significant for methylphenidate and atomoxetine. In adults, atomoxetine, cognitive behavioural therapy, methylphenidate (and, when restricting analyses to high quality trials, amphetamines) showed at least moderate certainty evidence of efficacy on ADHD symptoms, with medium effect sizes. Methylphenidate, amphetamines, and atomoxetine had worse tolerability than placebo (methylphenidate, risk ratio 0.50, 95% CI 0.36 to 0.69; amphetamines, 0.40, 0.22 to 0.72; atomoxetine, 0.45, 0.35 to 0.58). Some non-drug interventions (acupuncture and cognitive behavioural therapy in children and adolescents, and mindfulness in adults) showed large effect sizes for ADHD symptoms, but with low certainty evidence. No high certainty, long term evidence was found for any intervention. An online platform showing effects and evidence certainty of each intervention across age groups, time points, and outcomes (https://ebiadhd-database.org/) was developed.CONCLUSIONS: This review provides updated evidence to inform patients, practitioners, and guideline developers how best to manage ADHD symptoms. The online platform should facilitate the implementation of shared decision making in daily practice.TRIAL REGISTRATION: Open Science Framework https://osf.io/ugqy6/.}, issn = {0959-8138} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dahmenadkinsjennifer_2025, title = {Benefits of reflection-based monitoring in action research projects}, author = {Dahmen-Adkins, Jennifer and Peterson, Helen}, year = {2025}, journal = {Action Research}, volume = {23}, number = {2}, pages = {142--160}, doi = {10.1177/14767503241260963}, url = {1888425}, language = {eng}, publisher = {Sage Publications}, keywords = {monitoring; reflection; action research; gender equality; organisational change}, abstract = {This article reports on reflection-based monitoring tools developed and used in an action research project to improve gender equality in science and research institutions. Several of these tools were developed to facilitate individual and joint reflection from the perspective of the co-researchers involved. The aim of the article is to make the case for the integration of a systematic reflection-based monitoring approach, to describe its approach and theoretical underpinnings that link critical reflection theory with reflexive action learning theory, and to present the details of six monitoring tools so that they can be adopted in other project settings. It also highlights how these monitoring tools stimulated both individual and group reflection and how they facilitated the sharing of knowledge and experience between change agents involved in co-production. The article also shows that the process monitoring approach based on systematic reflection can contribute to successful project implementation and offers several important advantages.}, issn = {1476-7503} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wernrothmonalisa_2025, title = {Bereavement and type 1 diabetes in childhood : a register-based cohort study in Sweden}, author = {Wernroth, Mona-Lisa and Kennedy, Beatrice and Fall, Katja and Nguyen, Diem and Smew, Awad I. and Carlsson, Per-Ola and Svennblad, Bodil and Almqvist, Catarina and Fall, Tove}, year = {2025}, journal = {Diabetologia}, volume = {68}, number = {3}, pages = {549--556}, doi = {10.1007/s00125-024-06340-z}, url = {1923130}, language = {eng}, publisher = {Springer}, keywords = {bereavement; cohort; family caregiver; psychological stress; type 1 diabetes}, abstract = {AIMS/HYPOTHESIS: The potential impact of childhood bereavement-a severe psychological stressor-on childhood type 1 diabetes development remains unclear. Here, we aimed to bridge this knowledge gap and assess whether bereavement characteristics influenced any impact.METHODS: We conducted a register-based cohort study encompassing 3,598,159 children born in Sweden between 1987 and 2020. Childhood bereavement was defined as the death of a biological mother, father or sibling. Diagnosis of type 1 diabetes in childhood (<18 years) was ascertained through the National Patient Register. We applied a Cox proportional hazards regression model to investigate the impact of childhood bereavement on type 1 diabetes, while adjusting for potential confounders (including parental type 1 diabetes status, country of birth and demographic characteristics).RESULTS: During follow-up, 86,226 children (2.4%) lost a family member, and 18,817 children (0.52%) were diagnosed with type 1 diabetes (median age at onset 9.1 years). We did not detect any overall association between childhood bereavement and type 1 diabetes (adjusted HR 1.04; 95% CI 0.93, 1.17). We found no influence of age at loss, cause of death, familial relationship to the deceased, and time since loss.CONCLUSIONS/INTERPRETATION: In this large population-based Swedish study, we observed no evidence supporting a link between childhood bereavement and type 1 diabetes.}, issn = {0012-186X} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_anderssongreger_2025, title = {Berättelserna, samtiden och framtiden}, author = {Andersson, Greger}, year = {2025}, pages = {63--76}, url = {1993125}, language = {swe}, publisher = {Libris}, keywords = {eskatologi; bibeln; berättelser} } @book{ca0f099bbf2a435cee8f97bef5e8cbaa_anderssondaniel_2025, title = {Beskattning av fastigheter och bostadsrätter : Inkomstskatt, mervärdesskatt, fastighetsskatter och punktskatter}, author = {Andersson, Daniel and Grylin, Hanna and Kristoffersson, Eleonor}, year = {2025}, url = {2031815}, language = {swe}, publisher = {Studentlitteratur AB}, keywords = {skatterätt}, abstract = {I denna bok presenteras både lättillgängligt och i princip heltäckande den svenska och europarättsliga lagstiftningen om beskattning av fastigheter och bostadsrätter. Här behandlas inkomstbeskattning av privatbostäder, näringsfastigheter, näringsbostadsrätter, överlåtelse av privatbostäder, förbättringsutgifter, uppskov, skogsfrågor samt byggnadsrörelse. Även särregler för fastigheter och bostadsrätter på mervärdesskatteområdet tas upp, liksom regler om rot- och rutavdrag, oäkta bostadsrätter, punktskatter på fastighetsområdet, fastighetsskatt, fastighetsavgift och stämpelskatt. Denna andra upplaga utgår från skattereglerna så som de är utformade den 1 oktober 2025. Boken innehåller sedvanliga uppdateringar - inte minst har kapitlet om mervärdesskatt fått genomgripande förändringar i och med uppdateringen till 2023 års mervärdesskattelag. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fangs_2025, title = {Beta-blocker duration and long-term cardiovascular risk after myocardial infarction with reduced ejection fraction}, author = {Fang, S. and Macdonald, C. and Humphreys, A. and Fröbert, Ole and Jernberg, T. and Gaunt, T. R. and Berglund, A. and Walker, V and Matthews, A.}, year = {2025}, journal = {European Heart Journal}, volume = {46}, number = {Suppl. 1}, doi = {10.1093/eurheartj/ehaf784.4282}, url = {2037867}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background: Beta-blockers are recommended indefinitely for secondary prevention following myocardial infarction (MI) with reduced left ventricular ejection fraction (LVEF), but adherence to long-term beta-blockers decreases over time.Purpose: We investigated the effects of varying lengths of continuous beta-blocker use on the 6-year risk of cardiovascular outcomes after MI with reduced LVEF.Methods: We used observational data from Swedish national registers to emulate a pragmatic, randomized controlled trial of different durations of beta-blockers in eligible individuals who had an MI with LVEF <40% between September 2010 and February 2022. Five treatment strategies were compared: continuous oral metoprolol succinate or bisoprolol after MI for up to 6 months, 7 to 12 months, 13 to 18 months, 19 to 24 months, and more than 24 months. The primary outcome was a composite of all-cause death and recurrent non-fatal MI. All eligible participants were cloned to each treatment arm and censored when they no longer adhered to the treatment strategy in the specific arm to identify their follow-up time based on observed treatment duration and disease status. Inverse probability weighting adjusted for baseline and time-varying confounding and selection bias, incorporating demographics, clinical presentation, emergency and in-hospital care, comorbidities, biomarkers, and concomitant medications.Results: There were 5,849 eligible individuals with a mean age of 67.8 years, of which 4,872 (83.3%) were originally from Sweden and 1,408 (24.1%) were female. In addition, 3,054 (52.2%) of the individuals included were married or had a partner at baseline, and 1931 (33.0%) underwent secondary or higher education. The 6-year risk of the composite outcome was 25.4% (95% CI: 23.3%, 27.3%) for treatment up to 6 months, 24.3% (22.6%, 25.9%) for 7 to 12 months, 24.3% (22.4%, 25.9%) for 13 to 18 months, 23.8% (22.1%, 25.3%) for 19 to 24 months, and 23.1% (21.6%, 24.6%) for treatment beyond 24 months. Compared to the group who took the treatment for no longer than six months, risk differences ranged from -1.1% (-2.8%, 0.6%) for a treatment duration of 7 to 12 months to -2.3% (-4.3%, -0.2%) for treatment duration beyond 24 months. Similar trends were observed for all-cause death and recurrent MI separately.Conclusions: In individuals with MI and reduced LVEF, our target trial emulation supports continuous oral beta-blocker beyond two years to improve cardiovascular outcomes.}, issn = {0195-668X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_peltopiriveikko_2025, title = {Between rights and reality : patient perceptions of social inclusion in a forensic psychiatric clinic implementing safewards}, author = {Pelto-Piri, Veikko and Kjellin, Lars and Kronman, Linn and Wetterling, Jenny and Björkdahl, Anna}, year = {2025}, journal = {Frontiers in Psychiatry}, volume = {16}, doi = {10.3389/fpsyt.2025.1688564}, url = {2023115}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {safewards; forensic psychiatry; social inclusion; human rights; vulnerable populations; coercive measures; violence prevention; implementation}, abstract = {Background: Upholding human rights, including promoting patients' social inclusion, is essential in forensic psychiatric services to ensure socially sustainable development. Understanding how social inclusion it is perceived by patients is therefore important. Evidence suggests that the Safewards model can enhance social inclusion in inpatient settings. The aim of this study was to explore patients' perceptions of social inclusion in a forensic psychiatric clinic that implemented the Safewards model. To provide context, a secondary aim was to describe which Safewards interventions were implemented and how patients perceived them.Methods: Eight male patients from a forensic psychiatric clinic in Sweden were individually interviewed, focusing on Safewards and opportunities for social inclusion. Thematic content analysis was used to deductively code the data under the three core values of a social inclusion model: participation in decision-making, reciprocal relationships, and social justice. Themes for each value were thereafter developed inductively. For the secondary aim, a concise qualitative description was used to create an overview of patients' perceptions of Safewards.Results: Patients were aware of the Safewards interventions and were generally positive about them. Nine themes emerged: powerlessness when meeting the doctor; limited experience of involvement in daily decisions; desire to become involved in quality improvement efforts (participation in decision-making); staff members' availability and positive attitude; fellow patients exhibit care and consideration; withdrawal and avoidance of social interaction (reciprocal relationships); boredom and low mood within the ward; desire for dignified, equal, and safe care; and perception of unjustified confinement (social justice).Conclusion: The findings suggest that while Safewards may support more compassionate staff-patient relationships, it does not in itself ensure participatory or rights-based care. Achieving higher levels of social inclusion in forensic psychiatric services requires broader cultural and structural reforms beyond the implementation of individual models.} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_westberggustav_2025, title = {Betydelse i rörelse : Studier av det sociala livets semiotik. Per Ledins är denna festskrift}, author = {Westberg, Gustav}, year = {2025}, url = {1993685}, language = {swe}, publisher = {Örebro universitet}, keywords = {per ledin; semiotics; text analysis; discourse studies; genre; multimodality; semiotik; textanalys; diskursanalys; multimodalitet}, abstract = {Under en forskarkarriär som sträcker sig över mer än tre decennier har Per Ledin utforskat en mångfald aspekter av det sociala livets semiotik. Hans arbeten har gjort betydande avtryck inom fält som text- och genreanalys, diskursstudier, medieforskning, multimodalitet och skrivdidaktik. Denna festskrift samlar forskare som på olika sätt tar avstamp i och firar Ledins forskning. I bokens 25 bidrag undersöks allt från  matförpackningar, inredning, skriven text och bokformat till hashtaggar, fotografier, graffiti, memes, klistermärken och, inte minst, listor. Genom dessa semiotiska material belyses olika dimensioner av det sociala livet, såsom skräpproduktion, gymkultur, myndighetskommunikation, mötesformer i högre utbildning, forskningsstyrning, polisförhör, böner och psalmer, tobaksrökande, elevers skrivande, grammatisk stil, satir, egenremittering i vården, föreställningar om neuropsykiatriska diagnoser, läskris, supporterkultur, klimataktivism och juridikhistoria. De flesta kapitlen bygger på empiriska undersökningar, om än genom lite olika genrer. Boken innehåller även ett vetenskapshistoriskt bidrag om textforskningens utveckling och en samling semiotiska meditationer.;In a research career spanning more than three decades, Per Ledin has explored a variety of aspects of the semiotics of social life. His work has made a significant impact on fields such as text and genre analy-sis, discourse studies, media research, multimodality and writing didactics. This festschrift brings together scholars who in different ways draw on and celebrate Ledin's research. The book's 25 contribut-ions examine food packaging, interior design, written text and book formats to hashtags, photographs, graffiti, memes, stickers and, not least, lists. Through these semiotic materials, various dimensions of social life are illuminated, such as garbage production, gym culture, government communication, meeting forms in higher education, re-search governance, police interrogations, prayers and hymns, tobacco smoking, student writing, grammatical style, satire, self-referral in he-alth care, conceptions of neuropsychiatric diagnoses, reading crisis, supporter culture, climate activism, and legal history. Most chapters are based on empirical investigations, albeit through slightly different genres. The book also includes a contribution to the history of science on the development of research on texts, and a collection of semiotic meditations. }, file = {https://oru.diva-portal.org/smash/get/diva2:1993685/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ongjasonj_2025, title = {Beyond behavioural change : prioritising structural solutions to control bacterial sexually transmitted infections}, author = {Ong, Jason J. and Unemo, Magnus and Molina, Jean-Michel and Miranda, Angelica E. and Seib, Kate L. and de Mello, Maeve Brito and Doherty, Meg and Johnson, Cheryl C. and Delany-Moretlwe, Sinead and Fairley, Christopher}, year = {2025}, journal = {eClinicalMedicine}, volume = {83}, doi = {10.1016/j.eclinm.2025.103198}, url = {1956503}, language = {eng}, publisher = {Elsevier}, keywords = {sexually transmitted infections; public health intervention; diagnostics; global health strategy}, abstract = {With over 374 million new curable bacterial STI cases annually, we are far from meeting global health targets. Despite their serious consequences for sexual, reproductive, and mental health, control efforts often focus on individual-level interventions like condom promotion and behavior change, which are insufficient. A scientific framework for STI control emphasizes reducing infectiousness, decreasing the number of susceptible individuals, and lowering transmission probability. Effective strategies should focus on environmental modifications, including expanding access to quality sexual health care, rapid testing with same-visit treatment, and AI-enhanced diagnostics. Equally critical are protecting susceptible communities through vaccination and chemoprophylaxis (e.g., doxycycline post exposure prophylaxis). While individual behavioural interventions like condom promotion remain relevant, declining usage trends challenge their impact. Surveillance of STIs and antimicrobial resistance is essential, influ-encing all key drivers of transmission. To control STIs more effectively, we must shift from individual behaviour change to systems-level public health strategies. Prioritising accessible, stigma-free health services, leveraging technological advances, and investing in comprehensive public health policies will improve STI prevention and help meet global health goals.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_khanahmadsaeed_2025, title = {Beyond Causal Accuracy : Evaluating Representation Quality in Deep Treatment Effect Estimation}, author = {Khan, Ahmad Saeed and Schaffernicht, Erik and Stork, Johannes Andreas}, year = {2025}, url = {2028024}, language = {eng}, abstract = {Recent advances in treatment effect estimation (TEE) leverage deep neural networks to learn latent representations that balance treatment and control groups. However, despite their empirical success, we know remarkably little about the learned representations themselves—what structure they capture, why they lead to improved performance, and how far we can trust them. Existing evaluations focus almost exclusively on causal outcome metrics such as PEHE or ATE bias, leaving the representational mechanisms largely unexplored. This lack of understanding limits our ability to explain why models perform well, to identify when they fail, and to design more interpretable or trustworthy causal systems. In this work, we present a comprehensive analysis for representation-level evaluation of TEE methods. We benchmark CFR, DRCFR, TEDVAE and modern disentanglement-driven models using a unified suite of quantitative and graphical measures. Quantitatively, we assess AUC(T | Z) for confounding separability, Mutual Information (MI) retention for informativeness, MMD2 and SW1 for balance, CH-ratio for compactness, and Participation Ratio (PR) for effective dimensionality. Graphically, we analyze bias removal through embedding visualizations, kNN-mixing histograms, covariance heatmaps, and outcome-smoothness histograms—providing an interpretable view of latent geometry. Our analysis shows that modern VAE-based disentangling models yield more structured, balanced, and informative representations, which also correlate strongly with causal reliability. We provide a practical way to see inside TEE representations—revealing hidden biases, interpreting latent behavior, and understanding when conventional embedding properties (such as neighborhood preservation) may actually hinder bias mitigation. Overall, our findings emphasize that evaluating how models learn is essential to understanding why they perform well, paving the way toward more interpretable and trustworthy causal inference.}, file = {https://oru.diva-portal.org/smash/get/diva2:2028024/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_zdemirmetin_2025_1, title = {Beyond deficit models : Strengths-based perspectives on studying youth and families with immigration backgrounds}, author = {Özdemir, Metin and Altebo Nyathi, Sandra and Amouri, Layan and Amouri, Hasnaa}, year = {2025}, url = {2002350}, language = {eng}, abstract = {In societal discourse and academic research, individuals with immigration backgrounds are often portrayed as vulnerable and at risk. The term "risk" includes internalizing and externalizing issues such as poor mental health and adjustment difficulties. Despite increasing research on resilience and strengths-based approaches, psychological and prevention research remains focused on deficits. For instance, a keyword search on the Web of Science database for peerreviewed publications revealed that approximately 25% of studies on immigrant children and adolescents focused on some form of risk, while only around 3% listed resilience or strength as keywords.Several systematic reviews and meta-analyses demonstrated that interventions for individuals with immigrant backgrounds predominantly focused on mental health. Although mental health challenges may be more prevalent among individuals with immigrant backgrounds compared to the majority population, especially with those who experienced displacement and trauma, mental health support represents only one aspect of the broader spectrum of psychosocial needs among those with immigration experience.Building on this background, we will first provide an overview of current research and the portrayal of youth and families with immigration backgrounds. Following this, we will discuss the shortcomings of deficit-based approaches in prevention research. Finally, we will propose a contextualized developmental approach that may facilitate the development and implementation of strengths-based approaches to promote adjustment and well-being of immigrants and refugees.In summary, this paper aims to challenge the prevailing negative discourse about immigrant youth and parents as vulnerable and at-risk. Instead, the paper will discuss how a strengths-based approach may move prevention research targeting these groups forward, while also helping overcome the negative portrayal of immigrants and refugees as inherently at-risk.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_doylemaria_2025, title = {Beyond Fear of Crime : Exploring the True Worries of Older Adults in the Context of Fear of Crime and Vulnerability in Sweden}, author = {Doyle, Maria and Bood, Frida and Frogner, Louise and Golovchanova, Nadezhda and Hellfeldt, Karin}, year = {2025}, journal = {European Journal on Criminal Policy and Research}, doi = {10.1007/s10610-025-09631-2}, url = {1977015}, language = {eng}, publisher = {Springer}, keywords = {relevance of fear; fear of crime; perceived risk; avoidant behavior; frailty; older adults}, abstract = {The current study examines the relative importance of fear of crime and its three aspects—affective, behavioral, and cognitive—in relation to frailty (daily activities, health problems, psychosocial functioning), news consumption, trust in neighborhood, and perceptions of rising crime among older adults in a mid-sized Swedish municipality. Using logistic regression, we analyzed data from a subsample of 336 participants from a Swedish cross-sectional study of adults aged 65 and older (mean age = 76.62; age range = 64 to 106 years). Contrary to the common portrayal of older adults as highly fearful of crime, our findings reveal that their primary worries are more closely linked to health problems, social isola-tion, and other personal vulnerabilities than to fear of crime. Trust in the neighborhood is associated with lower levels of the affective and behavioral aspects of fear of crime. Conversely, perceptions of rising crime are positively related to the affective and behavioral aspects of fear. Health problems and problems in psychosocial functioning are positively linked to the affective aspect. Further, problems in psychosocial functioning are positively related to the behavioral aspect. Overall, while crime is a worry, it is overshadowed by more immediate health and social issues.}, issn = {0928-1371} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_demydyukganna_2025_1, title = {Beyond the Stars : Extending Potential of Internet Hotel Ratings Through Text Mining Analysis and Development of Experiencescapes}, author = {Demydyuk, Ganna and Singh Kaurav, Rahul Pratap and Carlbäck, Mats}, year = {2025}, journal = {The Hospitality Financial Management Review}, number = {Summer}, pages = {7--12}, url = {1987111}, language = {eng}, publisher = {International Association of Hospitality Financial Management Educators (iAHFME)} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_badacheandreea_2025, title = {Beyond the Years : How Sensory and Cognitive Functions in Old-Age Shape Disability, and Perspectives on Successful Aging : An epidemiological perspective of disability}, author = {Badache, Andreea}, year = {2025}, url = {1925105}, language = {eng}, publisher = {Örebro University}, keywords = {older adults; successful aging; sweden; denmark; sensory functions; prevalence; longitudinal epidemiology; adl; iadl; cognition; disability}, abstract = {AIMS: Research shows that the older population increases worldwide, which will likely lead to a rise in the number of people living with age-related disabilities (i.e. hearing and vision difficulties, physical mobility or cognitive ability). However, studies from the Nordic countries have indicated that the likelihood of having disabilities has decreased over time among older adults. This doctoral thesis is based on four studies, which collectively aim to analyze how older adults (aged 75 and above) perceive what constitutes successful aging, estimate the prevalence of hearing and vision impairments in different segments of the older population, examine the importance of cognitive abilities and hearing and vision in the observed declines in disabilities over time among older adults in Sweden and Denmark, and, finally, investigate the longitudinal interplay between sensory function and cognitive abilities among older adults.. METHODS: For Study I, a systematic review was conducted, while for Study II the prevalence of sensory difficulties was estimated. For Study III, the Karlson Holm Breen method was used to estimate the contribution of the cognitive and sensory functions on disability, whereas Study IV applied a cross-lagged panel model to explore the bidirectional relationship between sensory and cognitive functions. For study II, III and IV, data from the Survey of Health, Ageing and Retirement in Europe was used. RESULTS: The findings show that older adults’ own perceptions of successful aging include themes such as life, death, and environmental/systemic influences (Study I). Study II showed that the prevalence of hearing and vision impairments varied among different groups of older adults. Study III found that the decline in the prevalence of disabilities among older adults in Sweden and Denmark could be explained by improved cognition, education, and vision and hearing. Finally, the results from Study IV indicate that no reciprocal effects could be established between sensory functions and cognitive abilities in the short term. DISCUSSION: This thesis highlights the complex relationship between aging and disabilities in Sweden and Denmark and shows various perspectives on what successful aging means for older adults. The findings also reveal significant differences in the prevalence of hearing and vision difficulties among different groups of older adults and show that the prevalence of disabilities has decreased over time in the older population due to improvements in cognition, education, vision, and hearing. These results emphasize the importance of further research on how these factors, along with the use of assistive devices, have contributed to the observed trend. Further research, based on various types of studies and assumptions, is also needed to clarify whether there are any longitudinal associations between cognitive and sensory functions among older adults and, if so, to what extent they can be considered causal.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_qufangge_2025, title = {Bidirectional Association Between Parental Pressure to Eat and Children's Satiety Responsiveness : The Moderating Effect of Children's Temperament}, author = {Qu, Fangge and Chen, Yujia and Song, Xinyi and Wei, Xiaoxue and Wu, Ruxing and Wang, Jian and Cao, Yang and Guo, Ningyuan and Hua, Wenzhe and Chen, Jinjin and Tang, Xianqing and Zhu, Daqiao}, year = {2025}, journal = {Maternal and Child Nutrition}, volume = {21}, number = {2}, doi = {10.1111/mcn.13766}, url = {1914051}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {appetitive behaviour; child; feeding behaviour; parenting; temperament}, abstract = {This study aimed to examine the directionality of the relationship between children's satiety responsiveness and parental pressure to eat and to explore how children's temperament moderates this relationship. Parents of preschoolers (n = 482, Mage = 3.66, SD = 0.29, 51.2% boys) were surveyed at two-time points spaced 2 years in China, and 76.6% of those were mothers. Cross-lagged analyses indicated that children's satiety responsiveness positively predicted parental pressure to eat over time. Moderation analyses revealed that children's high anger/frustration intensified the predictive relationship above. These findings suggest that parents should accurately understand their children's satiety responsiveness and tailor their responses based on children's temperament, thereby fostering a virtuous cycle of parent-child interaction.}, issn = {1740-8695} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_amnerik_2025, title = {Bildning som rörelser : Samtal om bildningen i folkbildningen}, author = {Amnå, Erik and Åström, Eva}, year = {2025}, url = {1999175}, language = {swe}, publisher = {Folkbildningsrådet}, keywords = {bildning; folkbildning; fokusgrupper; folkhögskola; studieförbund}, abstract = {Folkbildningsrådet genomförde under 2023 och 2024 en studie för att undersöka folkbildningens bidrag till individers och samhällets bildning. Studien genomfördes genom ett antal fokusgruppsintervjuer med personer verksamma inom studieförbund och folkhögskolor.Tre huvudfrågor ställdes:— - Vad är bildning inom folkbildningen?— - Hur blir bildning till inom folkbildningen?— - Vilka värden skapar folkbildningens bildning?Folkbildningens bildning beskrivs av de intervjuade folkbildarna som en transformation av människan. En transformation som blir till genom att tillsammans med andra bearbeta och utveckla kunskaper, förhållningssätt och attityder.Folkbildarna identifierar tre grundläggande bildningskomponenter:— - Bildning bygger på egna och andras kunskaper.— - Bildning utvecklar förhållningssätt och attityder.— - Bildning är en förändringsprocess utan slut.Hur blir bildning då till? Vilka förutsättningar vill till för att folkbildningen ska kunna fungera bildande? Folkbildarnas svar handlar om mötesplatserna, om folkbildningens pedagogik, arbetssätt och frihetsgrader, och om deltagarnas och folkbildarnas öppenhet.Folkbildarna talar vidare om bildning som ”en kvalitet”, någonting som i sig är värdefullt och som är värt att sträva efter. Men vari ligger då detta värde? I intervjuerna beskriver folkbildarna de värden som just folkbildningens bildning bidrar till i samhället, och hur dessa vilar på bildningens värden för varje enskild människa:- Bildning är en viktig byggsten i ett samhälle som strävar efter sammanhållning, gemenskap och inkludering, där individen känner förståelse, tolerans och empati.— - Bildning bidrar till ett samhälle som präglas av demokratiskt deltagandeoch engagemang, där individen ser sammanhang, känner delaktighet ochstärker sin egenmakt.— - Bildning bidrar till välbefinnande och samhällskompetens och till en befolkning där individen har stark identitet och självkänsla.Individ och samhälle hör ihop – det som bildningen gör med människorna gör den också med de samhällen som människorna formar.Rapporten visar att det råder en betydande överensstämmelse mellan bildningsbegreppet som det används i den vetenskapliga diskussionen och inom samhällets bildande institutioner, som refereras i rapportens inledning, och som det används inom studieförbund och folkhögskolor. Den definition av bildningsbegreppet som utkristalliserar sig i folkbildarintervjuerna kan sammanfattas på följande sätt:Bildningen i folkbildningen är rörelser för att utforska och tolka världen tillsammans med andra. I möten söker, prövar och utvecklar individen sådana värderingar, kunskaper, känslor, färdigheter och förhållningssätt hon behöverför att vara människa och samhällsmedborgare med värdighet och ansvar för sig själv, för andra och för det gemensamma bästa.I den här studien ger folkbildarna inblickar i människors bildningsresor inom folkbildningen. Fokusgruppernas berättelser handlar om bildning som sätter liv i rörelse. Det är en sammanflätad personlig, kognitiv, praktisk, social och andlig rörelse där människor tillsammans och med olika sinnen utforskar jaget, vetandet, samhället och tillvaron i stort.}, file = {https://oru.diva-portal.org/smash/get/diva2:1999175/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_guerreirocarolinedea_2025, title = {Bioactive arabinoxylan oligomers via colonic fermentation and enzymatic catalysis : Evidence of interaction with toll-like receptors from in vitro, in silico and functional analysis}, author = {Guerreiro, Caroline de A. and Andrade, Leandro A.D. and Fernández-Lainez, Cynthia and Fraga, Layanne N. and López-Velázquez, Gabriel and Marques, Tatiana M. and Prado, Samira B. R. and Brummer, Robert J. and Nascimento, João Roberto O. and Castro Alves, Victor}, year = {2025}, journal = {Carbohydrate Polymers}, volume = {352}, doi = {10.1016/j.carbpol.2024.123175}, url = {1926792}, language = {eng}, publisher = {Elsevier}, keywords = {dietary fiber; oligosaccharides; mass spectrometry; reporter cells; toll-like receptors; molecular docking}, abstract = {Dietary fibers (DF) from plant-based foods promote health benefits through their physicochemical properties and fermentation by the gut microbiota, often studied in relation to changes in gut microbiota profile and production of gut microbiota-derived metabolites. Here, we characterized structural motifs (i.e., oligomers) produced during DF breakdown upon colonic fermentation and explored their interaction with toll-like receptors (TLRs) present on the surface of human intestinal and immune system cells. Wheat arabinoxylan (WAX) was subjected to in vitro colonic fermentation, with its structural motifs identified and tracked throughout the fermentation process. Using carbohydrate-active enzymes, six well-defined fractions of arabinoxylans and linear xylans identified during colonic fermentation were produced and tested for interaction with tool-like receptors (TLR)2 and TLR4 via reporter cell assay. The results showed structure-dependent effects, with TLR2 inhibition and TLR4 activation varying based on the degree of polymerization and branching. Molecular docking confirmed that minor structural changes in oligomers structure significantly influenced these interactions. The study supports the hypothesis that oligomers and polysaccharides affect cell receptors through complex, multi-receptor interactions, and highlights the potential for enzymatic tailoring of DF to create functional ingredients with targeted effects on human health.}, issn = {0144-8617}, file = {https://oru.diva-portal.org/smash/get/diva2:1926792/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stabyolsnjohan_2025_1, title = {Biochemical outcome of prostate cancer patients treated with hypofractionated external radiation and a single high-dose-rate brachytherapy boost}, author = {Staby Olsén, Johan and Valachis, Antonis and Karlsson, Leif and Johansson, Bengt}, year = {2025}, journal = {Brachytherapy}, volume = {24}, number = {1}, pages = {45--53}, doi = {10.1016/j.brachy.2024.07.005}, url = {1919289}, language = {eng}, publisher = {Elsevier}, keywords = {boost; bounce; brachytherapy; hdr; prostate cancer; radiation therapy}, abstract = {INTRODUCTION: Treating localized high-risk prostate cancer with a combination of external beam radiation therapy (EBRT) and high-dose-rate brachytherapy (HDR-BT) is a common approach. Moderately hypofractionated EBRT and a single HDR-BT boost simplifies the treatment. We aim to present our five-year results.METHODS: In this study, 355 patients treated with moderately hypofractionated EBRT (42 Gy in 14 fractions) and a single HDR-BT boost (14.5 Gy) at Örebro University Hospital between 2008 and 2018 were included. They were followed with regular PSA tests.RESULTS: The median age of the cohort was 70 years (range: 51-81) and the median follow-up duration was 56 months (range: 6-150). Among them, 45% were classified as very high-risk, 38% as high-risk and 17% as intermediate-risk. Adjuvant androgen deprivation therapy (ADT) with a median duration of 24 months was given to 75% of the patient cohort. The estimated 5-year failure free survival rates were 79% (whole cohort), 66% (very high-risk), 90% (high-risk) and 85% (intermediate-risk), respectively. Initial PSA > 10 ng/mL, Gleason score 9-10 and tumor stage T3 were significantly associated with biochemical failure (BF). A PSA bounce occurred in 53 (15%) cases and was inversely associated with BF (p = 0.001) for patients receiving ADT.CONCLUSIONS: Moderately hypofractionated EBRT and a single HDR-BT boost seems to be an effective treatment against intermediate- and high-risk localized prostate cancer. Treatment escalation strategies should be investigated for very high-risk patients where the risk of recurrence remains high.}, issn = {1538-4721} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_latifmuatasem_2025, title = {Biocide-resistant Pseudomonas oleovorans isolated from water-based coatings used in construction}, author = {Latif, Muatasem and Ferrieres, Lionel and Hyötyläinen, Tuulia and Jass, Jana}, year = {2025}, journal = {Journal of Industrial Microbiology & Biotechnology}, volume = {52}, doi = {10.1093/jimb/kuaf015}, url = {1979138}, language = {eng}, publisher = {Oxford University Press}, keywords = {pseudomonas oleovorans; 1; 2-benzisothiazolin-3(2h)-one (bit); 2-methylisothiazolin-3(2h)-one (mit); 5-chloro-2-methyl-isothiazolin-3-one (cmit); biocide resistance}, abstract = {Biocides are crucial in industrial applications to minimize microbial growth and prevent product spoilage. Water-based construction coatings are susceptible to microbial contamination during manufacturing and storage and this adversely impacts product properties, reduces shelf-life and leads to substantial commercial losses. The future trend to lower the biocide concentrations in water-based coatings raises concerns about the emergence of biocide-resistant microbes. This study aims to identify and characterize the biocide-resistant microbe isolated from construction water-based coating materials to better understand its mechanisms of resistance. A total of 63 samples were collected from spoiled products, raw materials, and water from a manufacturing facility, and Pseudomonas oleovorans P4A were identified in all biocides-treated samples. A comparison between a P. oleovorans reference strain, 1045, and the P4A isolate revealed distinct colony morphology, growth rate and sensitivity to biocides and antibiotics. The P4A isolate was 3-fold more resistant to 5-chloro-2-methyl-isothiazolin-3-one (CMIT) and 1.5-fold more resistant to benzothiazolinone (BIT) compared to the reference strain. Conversely, it was 1.4-fold more sensitive to methylisothiazolinone (MIT) compared to the reference strain. No cross-resistance to antibiotics was observed. Metabolomic analysis using liquid chromatography combined with high-resolution mass spectrometry of lipids and polar metabolites showed that P4A had a relatively higher amount of lipids, while 1045 had a relatively higher amount of polar metabolites identified. A significant difference in lipid composition, specifically in diacylglycerol, phosphatidic acid, phosphatidylcholine, and phosphatidylserine was observed between P. oleovorans strains 1045 and P4A. These distinctions highlight increased lipid metabolism in P. oleovorans P4A and this may contribute to its adaptation to biocides. Microbial resistance can directly affect the effectiveness of these products, leading to an increased need for frequent maintenance and replacement, safety concerns, and environmental implications.}, issn = {1367-5435} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_oskarssonsofi_2025, title = {Biological and psychological protective factors against the intergenerational transmission of criminal convictions: a total population, sibling comparison study}, author = {Oskarsson, Sofi and Tuvblad, Catherine and Lichtenstein, Paul and Larsson, Henrik and Latvala, Antti}, year = {2025}, url = {2000787}, language = {eng}, abstract = {Parental criminality is a risk factor for crime, but little is known about why some individuals exposed to this risk refrain from crime. We explored associations of resting heart rate (RHR), systolic blood pressure (SBP), cognitive ability (CA), and psychological functioning (PF) with criminal convictions among men with a convicted parent, accounting for unmeasured familial factors in sibling analyses. Data were obtained from Swedish registers, including all men born in Sweden between 1958 and 1992 with a convicted parent (N=495,109), followed for up to 48 years. The potential protective factors were measured at mandatory conscription. Outcomes were conviction of any, violent, and non-violent crime. Survival analyses were used to test for associations, adjusting for measured covariates and unmeasured familial factors. Higher levels of RHR, SBP, CA, and PF were associated with reduced risk of criminality after adjusting for covariates. RHR associations were largely explained by familial factors. CA and PF associations were not due to sibling-shared confounders, in line with a causal interpretation. SBP results, indicating a protective effect against non-violent crime, warrant further investigation.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_oldgrenjonas_2025, title = {Biomarker-based ABC-AF Risk Scores for Personalized Treatment to Reduce Stroke or Death in Atrial Fibrillation : a Registry-based Multicenter Randomized Controlled Study}, author = {Oldgren, Jonas and Hijazi, Ziad and Arheden, Håkan and Björkenheim, Anna and Frykman, Viveka and Janzon, Magnus and Ravn-Fischer, Annica and Renlund, Henrik and Själander, Anders and Åkerfeldt, Torbjörn and Wallentin, Lars}, year = {2025}, journal = {Circulation}, volume = {152}, number = {21}, pages = {1457--1469}, doi = {10.1161/CIRCULATIONAHA.125.076725}, url = {1993810}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, keywords = {atrial fibrillation; biomarkers; intracranial hemorrhages; risk factors; stroke}, abstract = {BACKGROUND: The clinical utility of risk scores to guide treatment decisions and improve clinical outcomes has rarely been prospectively evaluated. This study aimed to evaluate whether a biomarker-based ABC-AF risk score-guided multidimensional treatment strategy improves long-term outcomes in patients with atrial fibrillation (AF).METHODS: The multicenter, registry-based, randomized, controlled, open-label study enrolled adults with AF. In the active arm, the investigator was informed of each individual's ABC-AF-score risks for stroke and bleeding, which were used as decision support to tailor treatment recommendations, including preference for type of direct OAC. In the control arm, patient management was at the discretion of the investigator. Primary outcome was a composite of stroke or death. Secondary outcomes included stroke, death, major bleeding events, and their composite outcome.RESULTS: The intention-to-treat population comprised 3933 patients, median age 73.9 years, 33.6% women, 51.3% had paroxysmal AF, 11.2% had prior stroke or TIA, and 85.7% had OAC treatment. After randomization, 97.8% in active and 92.6% in control arm received OAC, p<0.0001. Enrollment was prematurely terminated owing to safety concerns with a trend towards higher mortality in patients with CHA2DS2-VASc scores of 3 or above, and the study was therefore underpowered for its primary objective. Over a median follow-up of 2.6 years, 175 primary events (3.18/100 patient-years [100PY]) occurred in the active and 148 (2.67/100PY) in the control arm, hazard ratio with 95% confidence interval (HR) 1.19, 0.96-1.48, p=0.12. Major bleeding events were 152 (2.82/100PY) versus 141 (2.61/100PY), HR 1.08; 0.86-1.36, p=0.50; stroke 48 (0.87/100PY) versus 41 (0.74/100PY), HR 1.18, 0.78-1.79, p=0.44; death 136 (2.44/100PY) versus 113 (2.02/100PY), HR 1.21, 0.94-1.55, p=0.13, and rates of the composite stroke, death, or major bleeding 277 (5.21/100PY) versus 244 (4.55/100PY), HR 1.14; 0.96-1.36, p=0.13. Primary outcome results were similar across ABC-AF-score subgroups (interaction p=0.98).CONCLUSIONS: The individually tailored multidimensional treatment strategy, based on ABC-AF risk scores, did not improve clinical outcomes as compared with usual guideline-based care in patients with AF. The results emphasize the need for prospective testing of the utility of risk stratification and precision medicine tools in different clinical settings before implementation in routine care.}, issn = {0009-7322} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_brambillamarta_2025, title = {Biomarkers of in vivo platelet activation in coronary artery disease : a systematic review and meta-analysis: communication from the SSC of the ISTH}, author = {Brambilla, Marta and Josefsson, Emma C. and Ramström, Sofia and Di Minno, Alessandro and Di Minno, Matteo Nicola Dario and Gangatirkar, Pradnya and Moujalled, Diane and Becchetti, Alessia and Lordkipanidzé, Marie and Camera, Marina}, year = {2025}, journal = {Journal of Thrombosis and Haemostasis}, volume = {23}, number = {12}, pages = {3989--4009}, doi = {10.1016/j.jtha.2025.07.014}, url = {1991191}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {coronary artery disease; meta-analysis; platelet activation; soluble biomarker; thrombotic risk}, abstract = {BACKGROUND: Given the role of platelets in coronary artery disease (CAD), assessment of a soluble platelet-activation marker may be useful to improve thrombotic risk stratification.OBJECTIVES: This study aimed to perform a meta-analysis investigating the association between levels of 14 such markers associated with CAD.METHODS: PubMed, Web of Science, and Excerpta Medica dataBASE (EMBASE) were searched until November 2024. The primary end point was the difference in levels of 11-dehydro-thromboxane B2, 2,3-dinor-thromboxane B2, β-thromboglobulin, soluble CD40L (sCD40L), glycocalicin, glycoprotein (GP)V, GPVI, matrix metalloproteinase (MMP)-9 and MMP-2, platelet factor (PF)4, soluble (s) P-selectin, SCUBE1, serotonin and thrombospondin (TSP)-1 between patients with CAD and healthy subjects (HSs) in plasma and/or serum. When possible, patients with CAD were stratified into acute coronary syndrome (ACS) and chronic coronary disease. Standardized mean difference (SMD) was calculated.RESULTS: Due to heterogeneity in the assessed studies, meta-analysis was performed for sCD40L, soluble GPV, MMP-9, PF4, sP-selectin, SCUBE1, and TSP-1. All markers but TSP-1 were significantly elevated in patients with CAD compared with HSs. Differences in sCD40L and SCUBE1 were statistically significant only when studies that assessed plasma were combined with those that assessed serum. When compared with HSs, the differences were bigger in patients with ACS than patients with chronic coronary disease for MMP-9 (SMD, 2.49 vs 0.49), PF4 (SMD, 2.01 vs 0.96), and sP-selectin (SMD, 1.81 vs 0.63). Publication bias was identified for sCD40L and, in ACS, for sP-selectin and PF4.CONCLUSION: The increased levels of sCD40L, soluble GPV, MMP-9, PF4, sP-selectin, and SCUBE1 in patients with CAD compared with HSs provide a rationale for designing new studies to address the potential of such molecules as biomarkers for thrombotic risk stratification.}, issn = {1538-7933} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrkenheimanna_2025, title = {Biomarkers of inflammation in sweat after myocardial infarction}, author = {Björkenheim, Anna and Sunnefeldt, Erik and Finke, Karl and Smith, Daniel Robert and Fröbert, Ole and Brasier, Noé}, year = {2025}, journal = {Scientific Reports}, volume = {15}, number = {1}, doi = {10.1038/s41598-025-90240-8}, url = {1937974}, language = {eng}, publisher = {Nature Publishing Group}, keywords = {acute myocardial infarction; biomarkers; inflammation; non-invasive monitoring; sweat analysis; wearables}, abstract = {ST-elevation myocardial infarction (STEMI) triggers a significant inflammatory response. Sweat may offer a novel, non-invasive medium for monitoring inflammation. In this prospective study, we characterized the inflammatory signatures in plasma and sweat collected from the skin surface of two patient groups: (1) 18 STEMI patients immediately following percutaneous coronary intervention (exposure) and (2) six patients who underwent outpatient angiography without subsequent intervention (control). Levels of 92 biomarkers were measured using a high-throughput proteomic assay and reassessed after 4-6 weeks in STEMI patients. Adjusting for patient group, sweat biomarkers did not show significant changes over time. In plasma, hepatocyte growth factor and interleukin-6 showed a significant decrease from the acute phase to follow-up, adjusted for patient group. STAM binding protein was significantly higher in the sweat of STEMI patients compared to controls, adjusted for time effects. While sweat was less sensitive than plasma for detecting biomarker levels in the setting of STEMI, its longitudinal analysis via wearable sensors holds promise for detecting specific markers.Trial registration: The trial is registered on www.clinicaltrials.gov with the trial registration number NCT05843006.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_querinvalentina_2025, title = {Biomarkers of lupus nephritis histopathology : Where do we stand?}, author = {Querin, Valentina and Palazzo, Leonardo and Fogo, Agnes and Haas, Mark and Jayne, David R. W. and Lightstone, Liz and Rovin, Brad and Seshan, Surya, V and Vaglio, Augusto and Parodis, Ioannis and Bajema, Ingeborg}, year = {2025}, journal = {Nephrology, Dialysis and Transplantation}, volume = {40}, number = {Suppl. 3}, doi = {10.1093/ndt/gfaf116.0289}, url = {2011736}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background and Aims: Systemic lupus erythematosus (SLE) is characterized by a complex and variable disease course, necessitating continuous clinical and laboratory assessments to monitor organ involvement and disease progression. Lupus nephritis (LN), thmost common organ-threatening manifestation of SLE, is commonly monitored using kidney biopsies, alongside blood and urine parameters. While kidney biopsy remains the gold standard for diagnosis, it is an invasive procedure and provides only a snapshot in time. Therefore, there is growing interest in non-invasive biomarkers that could improve clinical management of LN, aiding in diagnosis, prognostic assessment, and treatment decisions. By critically assessing the quality of existing studies on potential biomarkers—urinary, serum-based, or others—correlating with histological findings, we here explore the challenges in implementing these biomarkers in clinical practice and identify promising candidates for future validation.Method: A systematic literature search on LN biomarkers was conducted, extending a previous review by Palazzo et al. [1]. Studies in English, published between 2012 and 2024, and involving adult patients with biopsy-proven LN were included. The search focused on studies demonstrating significant correlations between biomarkers and histological findings, particularly the National Institutes of Health (NIH) activity index (AI) and chronicity index (CI), the International Society of Nephrology/Renal Pathology Society (ISN/RPS) histological classes, and specific active or chronic lesions. From this search, 96 articles were selected, investigating the potential utility of over 100 biomarkers, which were categorized into groups. The quality of each article was assessed by a multidisciplinary panel of experts utilizing the scoring system by Guyatt et al. [2].Results: The 96 publications were stratified into various biomarker categories: autoantibodies (n = 6), complement factors (n = 4), cytokines, chemokines, growth factors (n = 26), cell adhesion and surface molecules (n = 8), immune cells (n = 8), markers of kidney damage (n ≈ 20), micro-RNA (n ≈ 10), others (n ≈ 30). The biomarkers were tested against various lesions, both individual and combined, as well as measurements such as NIH AI and CI, and ISN/RPS classes. In quality assessment, over 50% of the articles were weak, 17% were very weak (score <5), and only 1 was deemed robust (score >8). Considering the scores of the respective articles, transforming growth factor beta 1 (TGF-β1) emerged as the biomarker deriving from the most robust study, followed by pentraxin 3 (PTX3), CD163, CD11b, hemopexin, and interleukin 16 (IL-16) (Figure 1).Conclusion: Our findings highlight the challenges in translating biomarker research into clinical practice for LN. Methodological heterogeneity across studies is a limitation to the interpretation of results. Furthermore, by focusing on selected markers, many studies oversimplify the intricate landscape of histological findings in a kidney biopsy. All clinical trials in LN should store samples for biomarker assessment and validation, prioritizing their ability to accurately reflect specific histological features, evolve with biopsy parameters over time, and demonstrate predictive value for long-term outcomes. Until substantial progress is made in the development of new biomarkers for LN, their clinical applicability will remain limited}, issn = {0931-0509} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_querinvalentina_2025_1, title = {Biomarkers of Lupus Nephritis Histopathology : Where Do We Stand?}, author = {Querin, Valentina and Palazzo, Leonardo and Fogo, Agnes B. and Haas, Mark and Jayne, David R. W. and Lightstone, Liz and Rovin, Brad H. and Seshan, Surya V. and Vaglio, Augusto and Parodis, Ioannis and Bajema, Ingeborg M.}, year = {2025}, journal = {Arthritis & Rheumatology}, doi = {10.1002/art.43427}, url = {2010754}, language = {eng}, publisher = {John Wiley & Sons}, abstract = {OBJECTIVE: Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify non-invasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in clinical practice and identify promising candidates for future validation.METHODS: A systematic literature search was conducted, including studies on adult patients with biopsy-proven LN, published between 2012 and 2024. The search focused on studies demonstrating correlations between biomarkers and histological findings, particularly the National Institutes of Health activity and chronicity indices, the International Society of Nephrology/Renal Pathology Society histological classes, and specific active and chronic lesions. The quality of selected articles was assessed by a multidisciplinary panel of experts utilizing a standardized scoring system.RESULTS: Ninety-three articles investigating the potential utility of over 100 biomarkers were selected. In quality assessment, 68% of the articles were weak or very weak (score<5, scale 2-9). From the remaining articles (adequate or robust) we identified five biomarkers with a potential for implementation in clinical practice: TGF-β1, PTX3, (s)CD163, CD11b, and IL-16.CONCLUSION: The methodological heterogeneity across studies and the overall moderate score of the quality of the articles represent obstacles to the implementation of new biomarkers into clinical practice. The LN working group advocates further research on selected biomarkers that demonstrated good capacity to reflect specific histopathological features outperforming traditional tests. At present, the choice of biomarkers that perform to these standards is very limited.}, issn = {2326-5191} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bodnarolha_2025_1, title = {Birge ratio method for modeling dark uncertainty in multivariate meta-analyses and inter-laboratory studies}, author = {Bodnar, Olha and Bodnar, Taras}, year = {2025}, journal = {Journal of Multivariate Analysis}, volume = {205}, doi = {10.1016/j.jmva.2024.105376}, url = {1908053}, language = {eng}, publisher = {Elsevier}, keywords = {birge ratio method; multivariate inter-laboratory comparisons; multivariate location-scale model; multivariate meta-analysis; multivariate random effects model}, abstract = {In the paper, we introduce a new approach for combining multivariate measurements obtained in individual studies. The procedure extends the Birge ratio method, a commonly used approach in physics in the univariate case, such as for the determination of physical constants, to multivariate observations. Statistical inference procedures are derived for the parameters of the multivariate location-scale model, which is related to the multivariate Birge ratio method. The new approach provides an alternative to the methods based on the application of the multivariate random effects model, which is commonly used for multivariate meta-analyses and inter-laboratory comparisons. In two empirical illustrations, we show that the introduced multivariate Birge ratio approach yields confidence intervals for the elements of the overall mean vector that are considerably narrower than those obtained by the methods derived under the multivariate random effects model.}, issn = {0047-259X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_skallsjg_2025, title = {Bleeding resuscitation in the ambulance service, an observational study of standard care in Sweden}, author = {Skallsjö, G. and Sandström, G. and Sato Folatre, J. G. and Harstad, A. M. and Åström Victorén, A. and Sömoen, E. and Höglund, Erik and Haglund, J. and Sköld, J. and Bergström, T. and Magnusson, C. and Wibring, K. and Romlin, B. and Wikman, A.}, year = {2025}, journal = {Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine}, volume = {33}, number = {1}, doi = {10.1186/s13049-025-01439-7}, url = {1988946}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {ambulance service; prehospital fluid resuscitation; prehospital coagulopathy; shock index; transfusion with blood products; trauma induced coagulopathy}, abstract = {Background: The ambulance service in Sweden has most often only crystalloids as resuscitation, even though restrictive use of clear fluids in bleeding patients is recommended. The aim of this study was to describe the treatment and outcome of bleeding patients treated by the ambulance service.Methods: This was a prospective observational multi-center study. Ambulance organizations in six different regions were invited to participate, each of them for a period of six months. Adult bleeding patients where fluid resuscitation with crystalloids was initiated by the ambulance service was consecutively included. Prehospital data on type of bleeding, mechanism and severity of injury, vital signs, estimated bleeding volume, treatment and transport time was collected from the ambulance service. Results from laboratory tests and data of transfusion requirements and mortality were obtained from the medical records, after hospital admission.Results: 181 patients were resuscitated with crystalloid fluids by the ambulance service and were included in the study. Gastrointestinal bleeding was the cause of fluid resuscitation in 48% of the patients and bleeding due to trauma in 23%. A high proportion of the patients (41%) had a coagulopathy upon admission at the hospital, defined as prothrombin time > 1,2, platelet count < 150 x 10(9)/L and/or activated prothrombin time > 32 s. Shock Index (SI) was 1.2 (mean) (SD 0.4). The mean volume of crystalloid fluids administered was 626 mL (SD 366), with one third of the patients receiving 1000 mL or more. Tranexamic acid was administered to 28% of the patients. Blood transfusions were given to 50% of the patients upon hospital admission. SI more than 1.3 predicted need of blood transfusions and bleeding > 500 mL predicted increased 24 h mortality. The overall 24-hour mortality was 7.2% and in patients with blood loss greater than 500 mL, the mortality rate was 12.1%.Conclusion: In this study gastrointestinal bleeding and trauma were the leading causes of severe prehospital bleeding. Blood loss over 500 mL and Shock Index above 1.3 were key predictors of poor outcome, highlighting the potential benefit of earlier blood product administration.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sigstrmrobert_2025, title = {Blood biomarkers of neuronal injury and astrocytic reactivity in electroconvulsive therapy}, author = {Sigström, Robert and Göteson, Andreas and Joas, Erik and Pålsson, Erik and Liberg, Benny and Nordenskjöld, Axel and Blennow, Kaj and Zetterberg, Henrik and Landén, Mikael}, year = {2025}, journal = {Molecular Psychiatry}, volume = {30}, number = {4}, pages = {1601--1609}, doi = {10.1038/s41380-024-02774-4}, url = {1903371}, language = {eng}, publisher = {Springer Nature}, abstract = {Despite electroconvulsive therapy (ECT) being recognized as an effective treatment for major depressive episodes (MDE), its application is subject to controversy due to concerns over cognitive side effects. The pathophysiology of these side effects is not well understood. Here, we examined the effects of ECT on blood-based biomarkers of neuronal injury and astrocytic reactivity. Participants with a major depressive episode (N = 99) underwent acute ECT. Blood was sampled just before (T0) and 30 min after (T1) the first ECT session, as well as just before the sixth session (T2; 48-72 h after the fifth session). Age- and sex-matched controls (N = 99) were recruited from the general population. Serum concentrations of neurofilament light chain (NfL), total tau protein, and glial fibrillary acidic protein (GFAP) were measured with ultrasensitive single-molecule array assays. Utilizing generalized least squares regression, we compared baseline (T0) biomarker concentrations against those of our control group, and calculated the shifts in serum biomarker concentrations from baseline to immediately post-first ECT session (T1), and prior to the sixth session (T2). Baseline analysis revealed that serum levels of NfL (p < 0.001) and tau (p = 0.036) were significantly elevated in ECT recipients compared with controls, whereas GFAP levels showed no significant difference. Relative to T0, serum NfL concentration neither changed at T1 (mean change 3.1%, 95%CI -0.5% to 6.7%, p = 0.088) nor at T2 (mean change -3.2%, 95%CI -7.6% to 1.5%, p = 0.18). Similarly, no change in total tau was observed (mean change 3.7%, 95%CI -11.6% to 21.7%, p = 0.65). GFAP increased from T0 to T1 (mean change 20.3%, 95%CI 14.6 to 26.3%, p < 0.001), but not from T0 to T2 (mean change -0.7%, 95%CI -5.8% to 4.8%, p = 0.82). In conclusion, our findings suggest that ECT induces a temporary increase in serum GFAP, possibly reflecting transient astrocytic activation. Importantly, we observed no indicators of neuronal damage or long-term elevation in any assessed biomarker.}, issn = {1359-4184} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bazarianjeffreyj_2025, title = {Blood-Based Biomarkers for Improved Characterization of Traumatic Brain Injury : Recommendations from the 2024 National Institute for Neurological Disorders and Stroke Traumatic Brain Injury Classification and Nomenclature Initiative Blood-Based Biomarkers Working Group}, author = {Bazarian, Jeffrey J. and Zetterberg, Henrik and Büki, Andras and Dengler, Bradley A. and Diaz-Arrastia, Ramon and Korley, Frederick K. and Lazarus, Rachel and Meier, Timothy B. and Mondello, Stefania and Moritz, Kasey and Okonkwo, David O. and Papa, Linda and Phillips, James B. and Posti, Jussi P. and Puccio, Ava M. and Sloley, Stephanie and Steyerberg, Ewout and Wang, Kevin K. and Awwad, Hibah O. and Dams-O'Connor, Kristen and Doperalski, Adele and Maas, Andrew I. R. and McCrea, Michael A. and Umoh, Nsini and Manley, Geoffrey T.}, year = {2025}, journal = {Journal of Neurotrauma}, volume = {42}, number = {13-14}, pages = {1065--1085}, doi = {10.1089/neu.2024.0581}, url = {1959577}, language = {eng}, publisher = {Mary Ann Liebert}, keywords = {s100b calcium-binding protein; brain biomarkers; concussion; glial fibrillary acidic protein; neurofilament light chain; traumatic brain injury; ubiquitin c-terminal hydrolase l1}, abstract = {A 2022 report by the National Academies of Sciences, Engineering, and Medicine called for a Traumatic Brain Injury (TBI) Classification Workshop by the National Institutes of Health (NIH) to develop a more precise, evidence-based classification system. The workshop aimed to revise the Glasgow Coma Scale-based system by incorporating neuroimaging and validated blood biomarker tests. In December 2022, the National Institute for Neurological Disorders and Stroke formed six working groups of TBI experts to make recommendations for this revision. This report presents the findings and recommendations from the blood-based biomarker (BBM) working group, including feedback from the workshop and subsequent public review. The application of BBMs in a TBI classification system has potential to allow for a more adaptable and nuanced approach to triage, diagnosis, prognosis, and treatment. Current evidence supports the use of glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase L1, and S100B calcium-binding protein (S100B) to assist in reclassification of TBI at acute time points (0-24 h) primarily in emergency department settings, while neurofilament light chain (NfL), GFAP, and S100B have utility at subacute time points (1-30 days) in-hospital and intensive care unit settings. Blood levels of these biomarkers reflect the extent of structural brain injury in TBI and may be useful for describing the extent of structural brain injury in a classification system. While there is insufficient evidence to support a role for BBMs at chronic time points (>30 days), emerging evidence suggests that NfL and phosphorylated tau may have a potential future role in this regard. For inclusion in a revised TBI classification system, BBM assays must have appropriate age- and sex-specific reference ranges, be harmonized across platforms, and achieve high analytical precision, including accuracy, linearity, detection limits, selectivity, recovery, reproducibility, and stability. Improving transparency in BBM assay development can be achieved through large-scale data sharing of methods and results. Future research should focus on methods for promoting clinical adoption of BBM results, correlating BBMs with advanced neuroimaging, and on discovering new biomarkers for improved diagnosis and prognosis.}, issn = {0897-7151} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zhaiyinghong_2025_2, title = {Body roundness index, depression, and the mediating role of lifestyle : Insights from the UK biobank cohort}, author = {Zhai, Yinghong and Hu, Fangyuan and Cao, Yang and Du, Run and Xue, Chao and Xu, Feng}, year = {2025}, journal = {Journal of Affective Disorders}, volume = {393}, number = {Part:A}, doi = {10.1016/j.jad.2025.120308}, url = {1997773}, language = {eng}, publisher = {Elsevier}, keywords = {body roundness index; depression; obesity; retrospective cohort study; uk biobank}, abstract = {BACKGROUND: The prospective association between body roundness index (BRI) and depression in the general population remains unclear.METHODS: This retrospective cohort study was conducted leveraging UK Biobank. The primary outcome was new-onset depression. Cox regression models were used to assess the association between BRI quartiles and depression, while restricted cubic splines were applied to explore the relationship between continuous BRI and depression. Mediation analyses were conducted to elucidate the role of educational, alcohol consumption, smoking, and physical activity.RESULTS: A total of 201,813 eligible participants with a mean age of 52.71 years were included. Over a mean follow-up period of 12.90 years, 7232 participants (3.58 %) developed depression. The cumulative incidence of depression differed significantly across the four BRI quartiles, with higher quartiles showing a progressively greater incidence of depression (P < 0.0001). In the fully adjusted Cox regression model, participants in the highest BRI quartile had a 30 % increased risk of developing depression (HR: 1.30, 95 % CI: 1.17-1.45; P < 0.0001) compared to those in the lowest quartile. Several lifestyle factors partly mediated the BRI-depression association, with smoking as the strongest mediator and physical activity conferring protection. LIMITATIONS: Residual or unmeasured confounding cannot be completely excluded, and caution is warranted when generalizing our findings to diverse ethnic populations.CONCLUSIONS: This study demonstrated a positive association between BRI and the incidence of depression. While lifestyle factors partially mediate the relationship between BRI and depression, the risk is primarily driven by the direct effects of BRI.}, issn = {0165-0327} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_1, title = {Bokrelease: Samtida marxistisk teori : Feministisk marxism}, author = {Johansson Wilén, Evelina}, year = {2025}, url = {2011425}, language = {swe} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_2, title = {Book launch: Judith Butler and Marxism : Approaches to Abolition}, author = {Johansson Wilén, Evelina}, year = {2025}, url = {2012463}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nergeliusjoakim_2025, title = {Book review: Anmälan. Patrik Emblad/Urban Strandberg (eds.), Proportionalitet - idéer och uppslag till forskning om proportionalitetens nya innebörder inom olika rättsliga fält, Stockholm (Jure) 2024}, author = {Nergelius, Joakim}, year = {2025}, journal = {Förvaltningsrättslig Tidskrift}, volume = {3}, pages = {465--466}, url = {2032192}, language = {swe}, publisher = {eddy.se ab}, keywords = {proportionality; conference; different legal fields; low result}, abstract = {A traditional but short review of a legal anthology.}, issn = {0015-8585} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dahlizabelaa_2025, title = {Book review: More than parcels : wartime aid for Jews in Nazi-Era camps and ghettos}, author = {Dahl, Izabela A.}, year = {2025}, journal = {Journal of Modern Jewish Studies}, volume = {24}, number = {1}, pages = {329--330}, doi = {10.1080/14725886.2024.2410181}, url = {1906381}, language = {eng}, publisher = {Routledge}, issn = {1472-5886} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ahkingmalin_2025, title = {Book review: Performance All the Way Down: Genes, Development, and Sexual Difference. Science-Culture Series by Richard O. Prum}, author = {Ah-King, Malin}, year = {2025}, journal = {The Quarterly review of biology}, volume = {100}, number = {1}, pages = {42--42}, doi = {10.1086/734519}, url = {1938460}, language = {eng}, publisher = {University of Chicago Press}, issn = {0033-5770} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karimzadehsara_2025, title = {Book Review: Rethinking Environmental Sociology: Moral Claims and Moral Meanings by John Hannigan}, author = {Karimzadeh, Sara}, year = {2025}, journal = {Acta Sociologica}, doi = {10.1177/00016993251377572}, url = {2003908}, language = {eng}, publisher = {Sage Publications}, issn = {0001-6993} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nestorsofia_2025, title = {Bothersome Pelvic Floor Dysfunction and Quality of Life During Pregnancy and Postpartum in Primiparous Women}, author = {Nestor, Sofia and Brynhildsen, Jan and Hiyoshi, Ayako and Jansson, Markus Harry}, year = {2025}, journal = {International Urogynecology Journal}, volume = {36}, number = {3}, pages = {635--646}, doi = {10.1007/s00192-024-06038-1}, url = {1930036}, language = {eng}, publisher = {Springer}, keywords = {childbirth; health-related quality of life; pelvic floor disorder; postpartum; urinary incontinence}, abstract = {INTRODUCTION AND HYPOTHESIS: This is a prospective cohort study based on the hypothesis that pregnancy and childbirth are associated with the occurrence of bothersome pelvic floor dysfunction (PFD), which impairs health-related quality of life (HRQoL).METHODS: Primiparous women completed a questionnaire including questions about bothersome PFD and HRQoL in early pregnancy, late pregnancy, 8 weeks postpartum, and 12 months postpartum. HRQoL was measured using the Incontinence Impact Questionnaire, Short Form (IIQ-7). The association between bothersome urinary incontinence (UI) 1 year postpartum and maternal and delivery characteristics was examined using generalized linear models.RESULTS: The study sample comprised 851 women. The prevalence of bothersome UI increased from 0.7% in early pregnancy to 8.1% at 1 year postpartum. At 1 year postpartum, 22.8% of the women reported PFD with impairment in HRQoL, with a median IIQ-7 score of 14.3. Bothersome UI in late pregnancy (adjusted RR 4.51, 95% CI 1.43-14.26) and 8 weeks postpartum (adjusted RR 10.17, 95% CI 5.45-18.98) were associated with bothersome UI 1 year postpartum.CONCLUSIONS: Most women were not bothered by UI during pregnancy and up to 1 year postpartum and did not report PFD with impairment in HRQoL. Most women who reported PFD with impairment in HRQoL had low IIQ-7 scores, but a few women reported substantial restriction in lifestyle. Bothersome UI in late pregnancy and 8 weeks postpartum was predictive of bothersome UI 1 year postpartum. This indicates the importance of the early identification of these women to provide appropriate counseling and treatment.}, issn = {0937-3462} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_qiul_2025, title = {Brain mechanisms mediating patient status and stress-induced negative affect in irritable bowel syndrome : The role of comorbidities}, author = {Qiu, L. and Bervoets, L. and Dooms, Y. and Bosman, M. and Keszthelyi, D. and Trindade, Ines and Simrén, M. and Tack, J. and Van Oudenhove, L. and Van Den Houte, M.}, year = {2025}, journal = {Neurogastroenterology and Motility}, volume = {37}, number = {Suppl. 2}, pages = {118--118}, url = {2040057}, language = {eng}, publisher = {John Wiley & Sons}, abstract = {Introduction: Irritable bowel syndrome (IBS) is a disorder of brain-gut interaction characterized by abdominal pain and altered bowel habits, often comorbid with anxiety, depression, chronic fatigue syndrome, and fibromyalgia. Psychosocial stress has been implicated in IBS, yet the underlying neural mechanisms and the role of comorbidities remain unclear. Therefore, we aimed to investigate (1) whether IBS patients exhibit in-creased self-reported negative affect (NA) and brain responses to stress, (2) the impact of comorbidities on these responses, and (3) the brain circuits mediating group differences in NA.Methods: We analyzed data from 96 IBS patients in the European DISCOvERIE project, and 64 healthy controls (HCs). 54 (56.3%) patients met criteria of depression, anxiety, chronic atigue syndrome, and/or fibromyalgia. Psychological stress was induced using the Montreal Imaging Stress Test during functional magnetic resonance imaging scanning, while NA ratings were collected across time (Figure 1A). Group differences in NA were tested using mixed models (all IBS vs. HCs; IBS-comorbid vs. IBS-alone), and stress-related brain activity was compared using general linear models. Multivariate mediation models were applied to identify brain response patterns mediating group differences in NA.Results: IBS patients reported more NA than HCs during stress (p < 0.01), driven by higher ratings from patients with comorbidities (p < 0.01; Fig 1B). The stress task induced higher brain activations in default mode network in IBS (Fig 1C), but no significant differences were found between comorbidity groups. Increased NA reporting in IBS patients vs HCs was mediated via heightened default mode network, salience network, and damp-ened central autonomic network responses (Fig 1D), and in IBS-comorbid vs. IBS-alone through altered responses in multiple somatosensory areas (Fig 1E).Conclusions: IBS patients experienced more negative affect than HCs under stress, driven by the presence of comorbidities. The hyperactive default mode network and salience net-work, combined with hypoactive central autonomic network as mediators of case-control differences in negative affect, indicate dysregulated central stress processing in IBS patients. Comorbidities may further amplify negative affect through altered somatosensory processing.}, issn = {1350-1925} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lundbergkjetilgrimastad_2025, title = {Branding work inclusion : exploring multimodal (re)presentation in the Scandinavian welfare state}, author = {Lundberg, Kjetil Grimastad and Sataøen, Hogne L.}, year = {2025}, journal = {International journal of sociology and social policy}, pages = {1--15}, doi = {10.1108/ijssp-12-2024-0626}, url = {1998601}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {work inclusion; active labor market measures; brand society; promotion; confessions; multimodality}, abstract = {Purpose: This article investigates how promotional strategies used by work inclusion organizations reflect broader shifts in the role of work within occupational rehabilitation and active labor market policies (ALMPs). By situating the analysis in the historical trajectory from sheltered workshops to governance-oriented models of inclusion, the study examines how branding practices, viewed through the lens of brand society theory, reshape representations of work and welfare in the Scandinavian context.Design/methodology/approach: A multimodal critical discourse analysis is conducted on promotional materials from two prominent organizations, Samhall (Sweden) and Work and Inclusion (Norway). The analysis is grounded in historical and theoretical perspectives, particularly the evolution of work in occupational rehabilitation and the concept of the brand society.Findings: The findings indicate that promotional materials adopt corporate aesthetics and idealized portrayals of work, aligning with branding logics. The use of personal confessions as a branding tool raises ethical questions related to authenticity and agency. While promoting inclusion, these materials also reinforce support for national welfare state models.Originality/value: This study contributes to the understanding of how branding practices intersect with work inclusion policy in Scandinavian welfare contexts. It offers an original theoretical synthesis of brand society and multimodal discourse analysis applied to ALMP implementation.}, issn = {0144-333X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_larssonannakarin_2025, title = {Breaking Norms : Depictions of Violent Girls in Swedish Newspapers}, author = {Larsson, Anna-Karin and Arnell, Linda and Moberg Stephenson, Maria}, year = {2025}, journal = {Deviant behavior}, volume = {46}, number = {5}, pages = {627--638}, doi = {10.1080/01639625.2024.2359613}, url = {1860886}, language = {eng}, publisher = {Routledge}, keywords = {flickor; våld; media; femininitet}, abstract = {This study explores the portrayal of girls engaged in violence within Swedish newspapers, focusing on contemporary representations in the media landscape. News media plays a pivotal role in shaping societal perceptions and norms, including those surrounding violence and gender. Analyzing media depictions of girls’ violence is crucial as it influences our understanding of gender norms and violence. We examined newspaper articles from 2021 to discern how violent girls were depicted, the portrayal of their actions, and whether they were given agency in the narratives. Utilizing gender theory with an intersectional lens, we scrutinized how Swedish media reported on and portrayed girls’ violence. Three key themes emerged: the characteristics of violent girls, the forms of violence, and explanations for their behavior. Notably, explanations for girls’ violence often focused narrowly on individual or relational factors, neglecting broader social contexts. Additionally, the girls were rarely given a platform to express their perspectives. Media portrayals positioned them as deviant from both feminine and violent norms, reinforcing societal stereotypes.}, issn = {0163-9625} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_valachisa_2025, title = {Bridging the gap : overcoming barriers to implementing gene expression profiling in clinical practice}, author = {Valachis, A and Matikas, A.}, year = {2025}, journal = {ESMO Real World Data and Digital Oncology}, volume = {8}, doi = {10.1016/j.esmorw.2025.100128}, url = {2026633}, language = {eng}, publisher = {Elsevier} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gunnarssonpontus_2025, title = {Broadly Sourced Alternative Proteins Alter Muscle Metabolome While Maintaining Sensory Quality in Rainbow Trout (Oncorhynchus mykiss)}, author = {Gunnarsson, Pontus and Eriksson Röhnisch, Hanna and Mihnea, Mihaela and Vidakovic, Aleksandar and Langeland, Markus and Kiessling, Anders and Dicksved, Johan}, year = {2025}, journal = {Journal of Agricultural and Food Chemistry}, volume = {73}, number = {44}, pages = {28511--28523}, doi = {10.1021/acs.jafc.5c07909}, url = {2008921}, language = {eng}, publisher = {American Chemical Society (ACS)}, keywords = {1h nmr; oncorhynchus mykiss; rata; rate-all-that-apply; alternative feeds; fillet; metabolomics; rainbow trout; sensory}, abstract = {Aquaculture is recognized as a key future food source, and to sustain increasing production and reduce the ecological footprint, new protein sources are needed. However, replacing the conventional fish and soybean meals may affect fillet quality. This study examined a phylogenetically broad set of protein sources and their effects on sensory attributes and metabolism of rainbow trout (Oncorhynchus mykiss). Five feeds derived from microfungi, black soldier fly, mealworm, blue mussel, and tunicate were evaluated against a soy-based control. Sensory attributes were assessed using Rate-All-That-Apply, and 1H NMR metabolomics to analyze feed and muscle metabolomes. Phylogenetically closer protein sources showed more similar feed and muscle metabolite profiles, and only minor differences in color, root vegetable taste, and aroma were found. Metabolic effects involved osmoregulation, energy, and amino acid metabolism. Overall, insect-based feeds appeared most favorable based on sensory results and product quality biomarkers; however, all tested feeds remained viable.}, issn = {0021-8561} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_marcussenwillemijnjg_2025, title = {Building human capital in the Dutch hospitality industry with a holistic EVP-model}, author = {Marcussen, Willemijn J. G. and Carlbäck, Mats and Jones, Adam}, year = {2025}, journal = {Journal of Human Resources in Hospitality & Tourism}, pages = {1--27}, doi = {10.1080/15332845.2025.2588520}, url = {2018437}, language = {eng}, publisher = {Routledge}, keywords = {human capital; employee retention; customer satisfaction; innovation; restaurants; employee value proposition}, abstract = {Developing human capital can significantly improve the com-petitive position of businesses in the hospitality sector. Insights are generated through combing the Job embeddedness frame-work with the employee Value Proposition model to analyze 10 semi-structured interviews with restaurant owners/managers in the Netherlands to reveal best practices for building human capital through successful employee retention. The results from the study highlight that many restaurants engage in one or more practices for building human capital. The identified practices include payment of wages above market rates, development of a realistic work-life balance, and investment in engaging with employees and in developing a supportive organization culture. However, the research revealed that most of these practices are not part of an integral plan. Findings support the development of a more structurally planned and aligned approach to retaining and engaging employees, which may help restaurants to develop their human capital to build and maintain a competitive advantage.}, issn = {1533-2845} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_2025, title = {Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023 : a systematic analysis for the Global Burden of Disease Study 2023}, year = {2025}, journal = {The Lancet}, volume = {406}, number = {10513}, pages = {1873--1922}, doi = {10.1016/S0140-6736(25)01637-X}, url = {2006089}, language = {eng}, publisher = {Elsevier}, abstract = {Background: For more than three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has provided a framework to quantify health loss due to diseases, injuries, and associated risk factors. This paper presents GBD 2023 findings on disease and injury burden and risk-attributable health loss, offering a global audit of the state of world health to inform public health priorities. This work captures the evolving landscape of health metrics across age groups, sexes, and locations, while reflecting on the remaining post-COVID-19 challenges to achieving our collective global health ambitions.Methods: The GBD 2023 combined analysis estimated years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs) for 375 diseases and injuries, and risk-attributable burden associated with 88 modifiable risk factors. Of the more than 310 000 total data sources used for all GBD 2023 (about 30% of which were new to this estimation round), more than 120 000 sources were used for estimation of disease and injury burden and 59 000 for risk factor estimation, and included vital registration systems, surveys, disease registries, and published scientific literature. Data were analysed using previously established modelling approaches, such as disease modelling meta-regression version 2.1 (DisMod-MR 2.1) and comparative risk assessment methods. Diseases and injuries were categorised into four levels on the basis of the established GBD cause hierarchy, as were risk factors using the GBD risk hierarchy. Estimates stratified by age, sex, location, and year from 1990 to 2023 were focused on disease-specific time trends over the 2010–23 period and presented as counts (to three significant figures) and age-standardised rates per 100 000 person-years (to one decimal place). For each measure, 95% uncertainty intervals [UIs] were calculated with the 2·5th and 97·5th percentile ordered values from a 250-draw distribution.Findings: Total numbers of global DALYs grew 6·1% (95% UI 4·0–8·1), from 2·64 billion (2·46–2·86) in 2010 to 2·80 billion (2·57–3·08) in 2023, but age-standardised DALY rates, which account for population growth and ageing, decreased by 12·6% (11·0–14·1), revealing large long-term health improvements. Non-communicable diseases (NCDs) contributed 1·45 billion (1·31–1·61) global DALYs in 2010, increasing to 1·80 billion (1·63–2·03) in 2023, alongside a concurrent 4·1% (1·9–6·3) reduction in age-standardised rates. Based on DALY counts, the leading level 3 NCDs in 2023 were ischaemic heart disease (193 million [176–209] DALYs), stroke (157 million [141–172]), and diabetes (90·2 million [75·2–107]), with the largest increases in age-standardised rates since 2010 occurring for anxiety disorders (62·8% [34·0–107·5]), depressive disorders (26·3% [11·6–42·9]), and diabetes (14·9% [7·5–25·6]). Remarkable health gains were made for communicable, maternal, neonatal, and nutritional (CMNN) diseases, with DALYs falling from 874 million (837–917) in 2010 to 681 million (642–736) in 2023, and a 25·8% (22·6–28·7) reduction in age-standardised DALY rates. During the COVID-19 pandemic, DALYs due to CMNN diseases rose but returned to pre-pandemic levels by 2023. From 2010 to 2023, decreases in age-standardised rates for CMNN diseases were led by rate decreases of 49·1% (32·7–61·0) for diarrhoeal diseases, 42·9% (38·0–48·0) for HIV/AIDS, and 42·2% (23·6–56·6) for tuberculosis. Neonatal disorders and lower respiratory infections remained the leading level 3 CMNN causes globally in 2023, although both showed notable rate decreases from 2010, declining by 16·5% (10·6–22·0) and 24·8% (7·4–36·7), respectively. Injury-related age-standardised DALY rates decreased by 15·6% (10·7–19·8) over the same period. Differences in burden due to NCDs, CMNN diseases, and injuries persisted across age, sex, time, and location. Based on our risk analysis, nearly 50% (1·27 billion [1·18–1·38]) of the roughly 2·80 billion total global DALYs in 2023 were attributable to the 88 risk factors analysed in GBD. Globally, the five level 3 risk factors contributing the highest proportion of risk-attributable DALYs were high systolic blood pressure (SBP), particulate matter pollution, high fasting plasma glucose (FPG), smoking, and low birthweight and short gestation—with high SBP accounting for 8·4% (6·9–10·0) of total DALYs. Of the three overarching level 1 GBD risk factor categories—behavioural, metabolic, and environmental and occupational—risk-attributable DALYs rose between 2010 and 2023 only for metabolic risks, increasing by 30·7% (24·8–37·3); however, age-standardised DALY rates attributable to metabolic risks decreased by 6·7% (2·0–11·0) over the same period. For all but three of the 25 leading level 3 risk factors, age-standardised rates dropped between 2010 and 2023—eg, declining by 54·4% (38·7–65·3) for unsafe sanitation, 50·5% (33·3–63·1) for unsafe water source, and 45·2% (25·6–72·0) for no access to handwashing facility, and by 44·9% (37·3–53·5) for child growth failure. The three leading level 3 risk factors for which age-standardised attributable DALY rates rose were high BMI (10·5% [0·1 to 20·9]), drug use (8·4% [2·6 to 15·3]), and high FPG (6·2% [–2·7 to 15·6]; non-significant).Interpretation: Our findings underscore the complex and dynamic nature of global health challenges. Since 2010, there have been large decreases in burden due to CMNN diseases and many environmental and behavioural risk factors, juxtaposed with sizeable increases in DALYs attributable to metabolic risk factors and NCDs in growing and ageing populations. This long-observed consequence of the global epidemiological transition was only temporarily interrupted by the COVID-19 pandemic. The substantially decreasing CMNN disease burden, despite the 2008 global financial crisis and pandemic-related disruptions, is one of the greatest collective public health successes known. However, these achievements are at risk of being reversed due to major cuts to development assistance for health globally, the effects of which will hit low-income countries with high burden the hardest. Without sustained investment in evidence-based interventions and policies, progress could stall or reverse, leading to widespread human costs and geopolitical instability. Moreover, the rising NCD burden necessitates intensified efforts to mitigate exposure to leading risk factors—eg, air pollution, smoking, and metabolic risks, such as high SBP, BMI, and FPG—including policies that promote food security, healthier diets, physical activity, and equitable and expanded access to potential treatments, such as GLP-1 receptor agonists. Decisive, coordinated action is needed to address long-standing yet growing health challenges, including depressive and anxiety disorders. Yet this can be only part of the solution. Our response to the NCD syndemic—the complex interaction of multiple health risks, social determinants, and systemic challenges—will define the future landscape of global health. To ensure human wellbeing, economic stability, and social equity, global action to sustain and advance health gains must prioritise reducing disparities by addressing socioeconomic and demographic determinants, ensuring equitable health-care access, tackling malnutrition, strengthening health systems, and improving vaccination coverage. We live in times of great opportunity.}, issn = {0140-6736} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mathewsimy_2025, title = {Burden of disease using disability adjusted life years in the Middle East and North Africa (MENA) region : protocol of a systematic review}, author = {Mathew, Simy and Sherif, Moustafa and Al-Rifai, Rami H. and Grivna, Michal and Östlundh, Linda and Devleesschauwer, Brecht and Ádám, Balázs}, year = {2025}, journal = {BMJ Open}, volume = {15}, number = {6}, doi = {10.1136/bmjopen-2024-096214}, url = {1976529}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {public health; systematic review}, abstract = {INTRODUCTION: In the Middle East and North Africa (MENA) region, changing demographic and epidemiological profiles have resulted in a diverse and shifting burden of disease (BoD). Disability-adjusted life years (DALYs), which combine years of life lost (YLL) due to premature mortality and years lived with disability (YLD), offer a valuable metric for assessing disease burden at the national level. While global burden of disease (GBD) estimates provide broad insights, national burden of disease (NBD) estimates offer country-specific data that can better inform tailored health policies and resource allocation. This systematic review protocol outlines our methodology for collating and analysing the NBD estimates in the MENA region using DALYs as the primary outcome measure.METHODS AND ANALYSIS: This review will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We will systematically search PubMed, Scopus, Web of Science and EMBASE for studies published from 1993 to 2024 that report national-level DALY estimates for diseases, injuries or risk factors in MENA countries. Eligible studies must report DALY estimates using national methodologies, while studies using exclusively GBD estimates will be excluded. Two independent reviewers will conduct title/abstract and full-text screening, data extraction and quality assessment using Standardised Reporting of Burden of Disease Studies (STROBOD), with disagreements resolved by a third reviewer when necessary.ETHICS AND DISSEMINATION: Ethical approval is not required for this review as it involves analysis of previously published data. The findings will be disseminated through publication in a peer-reviewed journal and presented at relevant academic and policy forums.PROSPERO REGISTRATION NUMBER: PROSPERO CRD42024498688.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sujiahui_2025, title = {Burden of per- and polyfluoroalkyl substances (PFAS) in human breast milk : Implications for maternal and infant health}, author = {Su, Jiahui and Gao, Yurou and Sun, Yumiao and Bing, Mengyao and Liu, Qian S. and Zhou, Qunfang and Fiedler, Heidelore and Jiang, Guibin}, year = {2025}, journal = {Environment International}, volume = {201}, doi = {10.1016/j.envint.2025.109593}, url = {1970058}, language = {eng}, publisher = {Elsevier}, keywords = {breast milk; estimated daily intake (edi); minimal risk values (mrvs); per- and polyfluoroalkyl substances (pfas); plasma concentration; risk assessment}, abstract = {Per- and polyfluoroalkyl substances (PFAS) are frequently detected in human breast milk. However, there is still limited understanding of the potential health risks associated with PFAS contamination in breast milk. In the present study, we calculated the plasma concentrations and estimated daily intakes (EDIs) of four PFAS, i.e. perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS) and perfluorononanoic acid (PFNA), based on a recently published study on PFAS concentrations in breast milk from five regions of the United Nations, and evaluated the potential health risks of PFAS. Risk assessment based on plasma PFAS concentrations indicated their potential deleterious effects on both mothers and infants, and notably infants were more vulnerable than mothers to PFAS exposure. Moreover, PFHxS and PFNA posed a higher health risk than PFOS and PFOA. Based on the calculation of toxicological data from animal studies using the method proposed by the Agency for Toxic Substances and Disease Registry (ATSDR), new minimal risk values (MRVs) proposed herein for infants were 3.35, 2.92, 0.25, and 0.38 ng/kg bw/d for PFOS, PFOA, PFHxS, and PFNA, respectively. The comparison of infant MRVs and EDIs further demonstrated the health hazards of PFAS exposure in infants via breast milk. This work indicated the potential maternal and infant health risks from human burden of PFAS, and the newly developed MRVs of four PFAS for infants would be more suitable than the health-based guidance values proposed by the ATSDR, in view of accurate assessment on the health threat to neonates from the exposure of this kind of emerging chemicals via breastfeeding.}, issn = {0160-4120} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sderkvistkarin_2025, title = {Calendar time trends in synchronous metastatic urinary bladder cancer before and after the introduction of immune checkpoint inhibitors : a nation-wide population-based cohort study}, author = {Söderkvist, Karin and Häggström, Christel and Hagberg, Oskar and Aljabery, Firas and Gårdmark, Truls and Holmberg, Lars and Hosseini, Abolfazl and Jerlström, Tomas and Kjölhede, Henrik and Malmström, Per-Uno and Sherif, Amir and Liedberg, Fredrik and Ullén, Anders}, year = {2025}, journal = {Frontiers in Oncology}, volume = {15}, doi = {10.3389/fonc.2025.1680916}, url = {2008104}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {checkpoint inhibitors (icis); metastatic disease; population based study; survival trends; urinary bladder cancer} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hazrarishi_2025, title = {Can Large Language Models Reason? A Characterization via 3-SAT}, author = {Hazra, Rishi and Venturato, Gabriele and Zuidberg dos Martires, Pedro and De Raedt, Luc}, year = {2025}, doi = {10.48550/arXiv.2408.07215}, url = {1993729}, language = {eng}, abstract = {Large Language Models (LLMs) have been touted as AI models possessing advanced reasoning abilities. However, recent works have shown that LLMs often bypass true reasoning using shortcuts, sparking skepticism. To study the reasoning capabilities in a principled fashion, we adopt a computational theory perspective and propose an experimental protocol centered on 3-SAT – the prototypical NP-complete problem lying at the core of logical reasoning and constraint satisfaction tasks. Specifically, we examine the phase transitions in random 3-SAT and characterize the reasoning abilities of LLMs by varying the inherent hardness of the problem instances. Our experimental evidence shows that LLMs are incapable of performing true reasoning, as required for solving 3-SAT problems. Moreover, we observe significant performance variation based on the inherent hardness of the problems – performing poorly on harder instances and vice versa. Importantly ,we show that integrating external reasoners can considerably enhance LLM performance. By following a principled experimental protocol, our study draws concrete conclusions and moves beyond the anecdotal evidence often found in LLM reasoning research.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_everhovsah_2025, title = {Cancer Incidence in Patients with Ulcerative Colitis Naïve to or Treated with Thiopurine and Targeted Therapies : a cohort study 2007 to 2022 with comparison to the general population}, author = {Everhov, Åsa H. and Askling, Johan and Söderling, Jonas and Halfvarson, Jonas and Eriksson, Julia and Smedby, Karin E. and Ludvigsson, Jonas F. and Sørensen, Henrik Toft and Olén, Ola}, year = {2025}, journal = {Journal of Crohn's & Colitis}, volume = {19}, number = {6}, doi = {10.1093/ecco-jcc/jjaf091}, url = {1967990}, language = {eng}, publisher = {Oxford University Press}, keywords = {cancer; incidence; inflammatory bowel disease; population-based; thiopurine; tofacitinib; tumour necrosis factor inhibitor; ulcerative colitis; ustekinumab; vedolizumab}, abstract = {BACKGROUND: Cancer incidence data including absolute risk differences are needed for clinical risk communication to patients receiving modern-day treatments for ulcerative colitis (UC).METHODS: We linked nationwide Swedish health registers and assessed incident cancers in patients with UC in 2007-2022. We computed age-stratified incidence rates (IRs), IR differences and hazard ratios (HRs) in a naïve cohort with no immunomodulatory treatment, and in cohorts treated with thiopurine or targeted therapies. General population comparator subjects were matched (by age, sex, calendar year, and area of residence) to each treatment cohort. We used a once-exposed - always exposed design.RESULTS: We identified 63,925 patients with UC in partly overlapping cohorts and 593,072 comparators with a total follow-up time of 5,800,089 years (median 8.1 years).The IRs were elevated compared to the general population in naïve patients: 2.7 extra cancer cases per 1000 person years (HR:1.12, 95%CI:1.09-1.16), in thiopurine-treated patients: 3.4 extra cases (HR:1.48;1.37-1.61), TNFi-treated: 2.7 extra cases (HR:1.41;1.24-1.62), Thiopurine+TNFi-treated: 2.42 extra cases (HR:1.44;1.19-1.75), vedolizumab-treated: 2.88 extra cases (HR:1.27;0.90-1.79). The IR differences were not significantly increased in patients treated with ustekinumab 0.57 (HR:0.87;0,39-1.93) and tofacitinib -0.69 (HR:0.84;0.25-2.77). Across all treatment groups, the IR differences compared to the general population were highest in patients ≥60 years. The differences were driven by colorectal cancer, hepatobiliary cancer, lymphoma, and basal cell skin carcinoma.CONCLUSION: Elevated cancer incidence was observed in patients with UC amounting to around 3 extra cases of cancer per 1000 years. Cancer risks varied more among groups defined by age than by treatment.}, issn = {1873-9946} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wannbergf_2025, title = {Cancer prediction using plasma protein profiling in patients with non-specific symptoms}, author = {Wannberg, F. and Álvez, M. Bueno and Qvick, Alvida and Pongracz, T. and Aguilera, K. and Adolfsson, Emma and Essehorn, L. E. and Gordon, M. and Uhlén, M. and Helenius, G. and Hjalmar, V. and Åberg, M. and Rosell, A. and Thålin, C.}, year = {2025}, journal = {Annals of Oncology}, volume = {36}, number = {Suppl. 2}, doi = {10.1016/j.annonc.2025.08.556}, url = {2040032}, language = {eng}, publisher = {Elsevier}, abstract = {Background: Cancer detection is challenging, especially in patients with diffuse symptoms that overlap with non-malignant conditions. Biomarkers could aid in identifying patients who could benefit from an accelerated diagnostic work-up.Methods: We conducted a prospective study including 456 patients presenting with non-specific symptoms and signs of cancer sampled prior to extensive diagnostic evaluation and cancer diagnosis at the Diagnostic Outpatient Clinic at Danderyd Hospital in Stockholm, Sweden. Plasma samples were analyzed using proximity extension assay-based proteomics, profiling 1463 proteins. A diagnostic model was developed using the Least Absolute Shrinkage and Selection Operator (LASSO) and validated in an independent replication cohort of 237 patients sampled prior to diagnostic work-up and cancer diagnosis at the Diagnostic Outpatient Clinic at Örebro University Hospital in Örebro, Sweden.Results: We identified 29 proteins associated with a new cancer diagnosis and developed a classification model able to stratify samples from 160 patients later diagnosed with cancer and 296 non-cancer patients with an AUC of 0.80. The model maintained its accuracy with an AUC of 0.82 in the independent replication cohort. Notably, the model not only distinguished between cancer and non-cancer, but also differentiated cancer from autoimmune, inflammatory and infectious diseases. Furthermore, we compared five cancer types (myeloma, lymphoma, neuroendocrine tumors, lung adenocarcinoma, and pancreatic/gallbladder/bile duct adenocarcinomas) against each other, revealing specific protein signatures for each.Conclusions: Cancer screening using minute amounts of blood is an attractive approach, and these findings emphasize the potential of blood proteome profiling to transform clinical medicine.}, issn = {0923-7534} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_houszying_2025, title = {Cancer-Associated Fibroblasts Move and Interact More with Triple-Negative Breast Cancer Cells and Stimulate Their Proliferation in a Hyaluronan-Dependent Manner}, author = {Hou, Sz-Ying and Macfarlane, Sarah C. and Gómez Torijano, Ariadna and Kim, Hyejeong Rosemary and Rosier, Marieke and Dobra, Katalin and Ottewell, Penelope D. and Gad, Annica}, year = {2025}, journal = {Cells}, volume = {14}, number = {21}, doi = {10.3390/cells14211663}, url = {2011666}, language = {eng}, publisher = {MDPI}, keywords = {cancer-associated fibroblasts; triple-negative breast cancer; 3d spheroid co-culture models; hyaluronan}, abstract = {While normal fibroblasts suppress tumor growth, during cancer initiation and progression, this capacity can be lost and even switched to tumor-promoting, for reasons that are not understood. In this study, we aimed to determine differences between patient-derived cancer-associated fibroblasts and fibroblasts from healthy breast tissue to identify if and how these changes stimulate Triple-negative breast cancer (TNBC). Two-dimensional and three-dimensional mono and co-cultures of TNBC cells with fibroblasts from healthy breast or TNBC were analyzed for cell contractility, migration, distribution, proliferation, and hyaluronan production by traction force microscopy, live cell imaging, flow cytometry, Western blot, and ELISA. In 3D spheroid co-culture, CAFs migrated into the tumor mass, mixing with tumor cells, whereas normal fibroblasts remained separate. In 2D, CAFs showed increased cell migration and contractile force, and, in both 2D and 3D co-culture, CAFs increased the proliferation of TNBC cells. CAFs showed increased production of hyaluronan, as compared to normal fibroblasts, and loss of hyaluronan synthase 2 reduced CAF-induced stimulation of TNBC proliferation. These findings suggest that increased production of hyaluronan by TNBC CAFs enhances their capacity to mix with and induce the proliferation of cancer cells, and that the production of hyaluronan by CAFs can be a future therapeutic target against TNBC.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_balasubramaniankavya_2025, title = {CANLP : Intrusion Detection for Controller Area Networks Using Natural Language Processing and Embedded Machine Learning}, author = {Balasubramanian, Kavya and Baragur, Adithya Gowda and Donadel, Denis and Sahabandu, Dinuka and Brighente, Alessandro and Ramasubramanian, Bhaskar and Conti, Mauro and Poovendran, Radha}, year = {2025}, journal = {IEEE Transactions on Dependable and Secure Computing}, volume = {22}, number = {6}, pages = {7203--7214}, doi = {10.1109/TDSC.2025.3596516}, url = {2026152}, language = {eng}, publisher = {IEEE}, keywords = {controller area networks; protocols; security; quantization (signal); intrusion detection; artificial neural networks; timing; standards; fuzzing; controller area network; term frequency- inverse document frequency}, abstract = {The Controller Area Network (CAN) protocol is the most widely used standard in the automotive industry for in-vehicle networks. However, the CAN protocol lacks essential security features such as encryption and message authentication. Absence of such security features has been shown to make the vehicle network vulnerable to exploits by an adversary. Although multiple types of intrusion detection systems (IDS) have been developed for CAN, it can be difficult to deploy them in real-time with low latency. Further, many of these IDSs are unable to isolate specific CAN frames on which an attack has been mounted, which makes it challenging to design defense mechanisms. In this paper, we develop CANLP, a Natural Language Processing (NLP)-based intrusion detection system to determine whether each transmitted message originated from a legitimate ECU or an adversary. CANLP uses Term Frequency-Inverse Document Frequency (TF-IDF), a NLP technique to discern complex features associated with CAN data and trains machine learning models to identify three types of attacks-fuzzing, spoofing, and masquerade. When an attack is detected, CANLP identifies the malicious CAN frame, which is important for developing resilient systems. Extensive experiments on 4 publicly available vehicle network datasets (which represent data collected from over three vehicle makes and four models) show that CANLP performs attack classification with high F1-scores of 0.9974. We also show that CANLP can be deployed for attack detection on resource-constrained hardware through implementation using RaspberryPi and experiments on a testbed with latency as low as < 0.05ms, making it suitable for real-world automotive applications such as fleet monitoring within the same vehicle class.}, issn = {1545-5971} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_viktorissonadam_2025, title = {Cardiac rehabilitation and physical activity decrease the risk of stroke after acute myocardial infarction : A nationwide cohort study in Sweden}, author = {Viktorisson, Adam and Buvarp, Dongni and Bäck, Maria and Leosdottir, Margret and von Euler, Mia and Sunnerhagen, Katharina S.}, year = {2025}, journal = {Annals of Physical and Rehabilitation Medicine}, volume = {68}, number = {5}, doi = {10.1016/j.rehab.2025.101971}, url = {1954446}, language = {eng}, publisher = {Elsevier}, keywords = {cardiac rehabilitation; incidence; myocardial infarction; physical activity; risk factors; stroke}, abstract = {BACKGROUND: Stroke and acute myocardial infarction (AMI) rank among the leading causes of mortality. Physical activity and exercise are recommended as part of rehabilitation after AMI to prevent cardiovascular events, but the importance for stroke prevention has not been investigated using population-based data.OBJECTIVES: To determine associations between participation in exercise-based cardiac rehabilitation (EBCR) and self-reported physical activity with the risk of total stroke, ischemic stroke, and intracerebral hemorrhage after AMI.METHODS: This was a nationwide, double cohort study conducted across all coronary care units in Sweden between 2005 and 2020, combined with registered data from the general population. Participation in EBCR (24 physiotherapist-led sessions over 4 months) and self-reported physical activity were assessed at a median of 55 days (range 28-90) after hospital discharge. Stroke incidence was followed until death or censoring on December 31, 2021.RESULTS: A total of 86,637 people with AMI (mean age 64.0, SD 9.0 years; 26 % female), and 259,911 (1:3) age, sex, and region of birth matched individuals from the general population were included. Participation in EBCR after AMI was associated with a lower risk of total stroke (adjusted hazard ratio, aHR 0.85; 95 % confidence interval, CI 0.80-0.91) compared to non-participants, as was ≥150 min of physical activity per week (aHR 0.79, 95 % CI 0.75-0.83). Those reporting physical activity 6 days per week after AMI did not have an increased risk of total stroke or ischemic stroke compared to the general population (aHR 1.03, 95 % CI 0.87-1.23; and aHR 1.17, 95 % CI 0.97-1.41), and were at lower risk of intracerebral hemorrhage (aHR 0.59, 95 % CI 0.35-0.98).CONCLUSIONS: EBCR and higher levels of physical activity are associated with a decreased risk of stroke after AMI. Cardiac rehabilitation programs and regular and physical activity should be promoted after AMI to decrease the burden of stroke. Swedish Ethical Review Authority Registration number: 2021-03645.}, issn = {1877-0657} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sundhjosefin_2025_1, title = {Cardiovascular disease and mortality in COPD - real-world data from the PRAXIS study}, author = {Sundh, Josefin and Montgomery, Scott and Hasselgren, Mikael and Giezeman, Maaike and Eliason, Gabriella and Karlsson, Mikael and Sandelowsky, Hanna and Nager, Anna and Kisiel, Marta and Lisspers, Karin and Ställberg, Björn and Janson, Christer}, year = {2025}, journal = {European Respiratory Journal}, volume = {66}, number = {Suppl. 69}, doi = {10.1183/13993003.congress-2025.OA4450}, url = {2037066}, language = {eng}, publisher = {European Respiratory Society}, abstract = {Background: General management of cardiovascular diseases have improved, and inhaled corticosteroids (ICS) have also been suggested to decrease cardiovascular risk in COPD.Aim: To compare prevalence of cardiac disease and ten-year cardiovascular mortality in COPD during the two recent decades, and to investigate if ICS treatment is associated with decreased cardiovascular mortality in COPD.Methods: Longitudinal real-world data from the two separate PRAXIS study cohorts created in 2005 (n=1071) and 2014 (n=1671) in central Sweden. Baseline data from questionnaires and medical record reviews in 2005 and 2014, and mortality data from the national Cause of Death Register in 2015 and 2024, respectively. Cross-tabulations and chi-2 test were used to explore prevalence of comorbid heart disease (ischemic heart disease or heart failure) and cardiovascular deaths. In a merged population with both cohorts, Cox regression was used to analyse risk of cardiac death with adjustment for sex and baseline age, body mass index, heart disease, health status, exacerbations and GOLD stage.Results: Between cohorts, cardiac disease prevalence (25 vs 22%, p=0.170), cardiac mortality rate (12 vs 10%, p=0.098) and overall ratio of cardiovascular and all-cause mortality (26 vs 22%, p=0.084) did not differ significantly. Maintenance treatment with ICS was independently associated with lower cardiovascular mortality (HR [95%CI] 0.62 [0.43-0.89], particularly in men (0.46 [0.29 to 0.74]), non-exacerbators (0.52 [0.33-0.81]) and severe COPD (0.57 [0.33 to 0.98]).Conclusion: Cardiac prevalence and mortality in COPD has not changed during the recent two decades. ICS may be of benefit to prevent cardiovascular mortality in COPD.}, issn = {0903-1936} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_niemistcharlotta_2025, title = {Care}, author = {Niemistö, Charlotta and Hearn, Jeff}, year = {2025}, pages = {44--46}, doi = {10.4337/9781803922065.ch11}, url = {1938757}, language = {eng}, publisher = {Edward Elgar}, keywords = {care; gender; organisation; management}, abstract = {The concept of care, like that of work, is very broad and multifaceted. It can refer to many different forms of care: physical, psychological, social and spiritual. Care can also refer to organized systems of care, for example health care, social care, institutional care and home care. Care can be conceptualized both as work, in terms of care work conducted, and as more than work alone, as in care for others, one’s or others’ children and other dependents, as well as for oneself. According to Tronto (2013), care can entail: caring about; taking care of; giving care; receiving care; caring with, as with solidarity. Care can thus be used more widely still to refer to care for animals, non-humans, the environment and the planet.}, file = {https://oru.diva-portal.org/smash/get/diva2:1938757/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_elaccarisandra_2025, title = {Caring for the Caregivers : Ageing Masculinity and Male Camaraderie and Caring in Paco Roca’s Arrugas}, author = {El Accari, Sandra and de Boise, Sam}, year = {2025}, journal = {Bulletin of Spanish Studies}, volume = {102}, number = {4}, pages = {831--857}, doi = {10.1080/14753820.2025.2501835}, url = {1961944}, language = {eng}, publisher = {Routledge}, keywords = {caring masculinity: friendship; camaraderie; interdependence; caregiving; ageing; masculinity; paco roca; arrugas (2007); twenty-first century spanish film}, abstract = {The topic of caring in relation to ageing masculinity, specifically how ageing often entails both giving and receiving care, has received increasing attention over the last fifteen years in academic literature as well as representations in literature, art and film. One such film is Arrugas (Paco Roca, 2007) a much-praised Spanish-language film. Adopting the framework of caring masculinities, this paper argues for the empowerment and visibility of the caregiver depicted in Arrugas and analyses Miguel’s role as a male guide in the traditionally ‘feminised’ environment of the nursing home.}, issn = {1475-3820} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wojnickakatarzyna_2025, title = {Caring Masculinities : Rethinking the Concept}, author = {Wojnicka, Katarzyna and de Boise, Sam}, year = {2025}, journal = {Men and Masculinities}, volume = {28}, number = {4}, pages = {339--358}, doi = {10.1177/1097184x251327673}, url = {1945194}, language = {eng}, publisher = {Sage Publications}, keywords = {caring masculinity; caring masculinities; theory; protective masculinity; hybrid masculinities}, abstract = {The aim of this article is to critically evaluate the concept of caring masculinity/ies, a concept that has gained traction in critical studies on men and masculinities (CSMM) since the publication of Karla Elliott’s 2016 article. Utilizing a rapid literature review, this study analyses 54 peer-reviewed papers published in English-language journals since 2016. The paper begins with an overview of the early development of caring masculinities, tracing its theoretical roots and initial applications. It subsequently categorizes the dominant ways in which the concept has been applied, focusing on typologies, caring practices, and processes of change, as well as on criticism of the concept. The paper then discusses key critical junctions and limitations, particularly on the conflation of attitudes with practice. It finally calls for a more coherent focus on caring practices that emphasizes the importance of intersectionality, the initial feminist promise of the concept and greater attention to the structural barriers that may enable, shape or restrict men’s caring.}, issn = {1097-184X}, file = {https://oru.diva-portal.org/smash/get/diva2:1945194/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kerezoudievangelian_2025, title = {Carrot Rhamnogalacturonan-I Supplementation Shapes Gut Microbiota and Immune Responses : A Randomised Trial in Healthy Adults}, author = {Kerezoudi, Evangelia N. and McKay, Sue and Kurt, Seta and De Kreek, Maaike and De Medts, Jelle and Verstrepen, Lynn and Ghyselinck, Jonas and Van Meulebroek, Lieven and Calame, Wim and Mercenier, Annick and Albers, Ruud and Brummer, Robert Jan and Rangel, Ignacio}, year = {2025}, journal = {Microorganisms}, volume = {13}, number = {9}, doi = {10.3390/microorganisms13092156}, url = {2001837}, language = {eng}, publisher = {MDPI}, keywords = {dc activation; bifidobacteria; crg-i; diarrhoea score; healthy adults; prebiotic; rhamnogalacturonan-i}, abstract = {Background: Rhamnogalacturonan-I (RG-I) is a pectic polysaccharide with emerging prebiotic and immunomodulatory potential. This randomised, double-blind, placebo-controlled trial (ID: NCT06081972) evaluated the effects of carrot-derived RG-I (cRG-I) supplementation, compared to placebo (maltodextrin), on gut microbiota composition and immune cell activation in healthy adults.Methods: A total of 54 participants (18-70 years old) were randomised in a double-blind manner to receive either 500 mg/day of cRG-I or placebo for four weeks. Pre-screening ensured balanced randomisation based on habitual fibre intake and faecal Bifidobacterium counts. Questionnaires assessed potential gut health and well-being effects, while in vitro and ex vivo models were used to evaluate effects on intestinal permeability.Results: cRG-I was well tolerated with excellent compliance. Faecal Bifidobacterium counts increased significantly, peaking at week 3. Isobutyric acid levels rose, though no other SCFAs differed. Immunologically, cRG-I enhanced the percentage of circulating myeloid dendritic cells expressing activation markers (CD86, HLA-DR) on. Stool consistency improved slightly. Preclinical models further showed that cRG-I and its fermentation products protected intestinal barrier integrity under stress.Conclusion: These results support cRG-I as a safe, low-dose dietary intervention capable of beneficially modulating gut microbiota, immune responses, and barrier function in healthy adults within a short supplementation period.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_pergertpernilla_2025, title = {Case-Based Clinical Ethics Support - A Description and Normative Discussion of Methodological Issues from the Swedish Perspective}, author = {Pergert, Pernilla and Svantesson, Mia and Bartholdson, Cecilia and Bremer, Anders and Brännström, Margareta and Fischer Grönlund, Catarina and Juth, Niklas and Björk, Joar}, year = {2025}, journal = {HEC Forum}, doi = {10.1007/s10730-025-09566-5}, url = {2005962}, language = {eng}, publisher = {Springer}, keywords = {clinical ethics support; ethics case reflection; mixed-method; moral case deliberation; normative discussion; survey}, abstract = {Clinical Ethics Support (CES) includes various forms of systematic support to deal with ethical challenges in healthcare and case-based CES (C-CES) is used for CES in particular cases. The aim was to describe and normatively discuss organizational and methodological aspects of C-CES used in Swedish healthcare. A mixed-methods approach was used. A descriptive survey was answered regarding eight organizations on hospital, regional and national level, with large variations in the number of conducted C-CES activities. Data were compiled and frequencies calculated. Based on the survey results, normative questions were formulated. Six participants, with expertise of C-CES, participated in a normative group discussion. Field notes and transcribed data were analysed qualitatively. The top ranked goal of C-CES was "Supporting decision making". Mainly prospective cases were used and C-CES was carried out as un-planned and pre-planned sessions. The normative results showed the importance of avoiding making C-CES unattractive to clinicians, for instance by keeping the time frame. The professional backgrounds of C-CES leaders varied greatly and arguments were provided for the facilitating role and that C-CES leaders ought not facilitate where they have been clinically engaged. Identified challenges included variations in uptake of C-CES activities that do not mirror the ethical challenges of the context. The unfair uptake of C-CES can be compared with the uptake in Norway where there are legal requirements for CES. In this study patients and families were not reported to request or attend C-CES. Thus, further research and interventions are needed to ensure their representation in Swedish C-CES.}, issn = {0956-2737} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_khandokhando_2025, title = {Cash to Cashless : A Systematic Review of Factors Shaping Merchant Adoption}, author = {Khando, Khando and Gao, Shang and Petersson, Johan}, year = {2025}, volume = {16079}, pages = {452--469}, doi = {10.1007/978-3-032-06164-5_32}, url = {2032377}, language = {eng}, publisher = {Springer}, keywords = {cashless; cashless payment systems; merchant adoption; toe framework; systematic review}, abstract = {While much research has focused on consumer and technological aspects of cashless payment systems, fewer studies address this topic from the merchants’ perspective. This study examines the factors influencing merchants’ adoption of cashless payment systems using the Technology-Organization-Environment (TOE) framework. Through a systematic review of 33 relevant studies, it synthesizes key insights into how technological factors (e.g., compatibility, perceived usefulness, and security), organizational factors (e.g., knowledge and skills, cost and revenue, merchant background, and perceived trust), and environmental factors (e.g., customer demand, competitive pressure, policies, and regulations) shape merchants’ adoption decisions. This paper highlights the interrelated nature of these factors, providing a holistic understanding of cashless payment systems adoption. Using the TOE framework, this review categorizes internal and external influences while offering theoretical insights into their complex interplay across contexts. The findings are valuable for businesses, regulators, payment service providers, and payment infrastructure developers seeking to promote cashless payment adoption among merchants.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_montanbryce_2025, title = {Catheter and Surgical Ablation for Atrial Fibrillation : A Systematic Review and Meta-analysis}, author = {Montané, Bryce and Zhang, Shiyang and Wolfe, Jonathan D. and Prime, Sabrina and Luo, Chongliang and Cooper, Daniel H. and Doering, Michelle and Blomström-Lundqvist, Carina and Nashef, Samer A. M. and Osmancik, Pavel and Andrade, Jason G. and Bertaglia, Emanuele and Parkash, Ratika and Mark, Daniel B. and Nielsen, Jens C. and Sharples, Linda D. and Gage, Brian F.}, year = {2025}, journal = {Annals of Internal Medicine}, volume = {178}, number = {8}, pages = {1138--1149}, doi = {10.7326/ANNALS-25-00253}, url = {1981393}, language = {eng}, publisher = {Annals of Internal Medicine}, abstract = {BACKGROUND: Ablation of atrial fibrillation can restore normal heart rhythm, but its effect on clinical outcomes is uncertain. PURPOSE: To determine the effect of ablation on ischemic stroke at more than 30 days (primary outcome).DATA SOURCES: Search of 9 databases without language restrictions from 1 January 1987 to 13 September 2024, and bridge search of 2 databases to 1 May 2025.STUDY SELECTION: Randomized controlled trials of catheter or surgical ablation versus no ablation that had at least 1 month of follow-up and reported stroke and/or mortality.DATA EXTRACTION: Dual independent data extraction and risk-of-bias assessment.DATA SYNTHESIS: Compared with medical therapy, catheter ablation reduced risks for ischemic stroke after 30 days (relative risk [RR], 0.63 [95% CI, 0.43 to 0.92]), mortality (RR, 0.73 [CI, 0.60 to 0.88]), and heart failure (HF) hospitalization (RR, 0.68 [CI, 0.55 to 0.85]). However, catheter ablation increased the RR for ischemic stroke at or before 30 days (6.81 [CI, 1.56 to 29.8]) such that the RRs were 0.77 (CI, 0.55 to 1.09) for any ischemic stroke and 0.77 (CI, 0.57 to 1.05) for all strokes. Surgical ablation reduced the RRs for ischemic stroke (0.54 [CI, 0.34 to 0.86]) and stroke from any cause (0.54 [CI, 0.35 to 0.82]) but had uncertain benefit for other outcomes; RRs were 0.63 (CI, 0.37 to 1.06) for ischemic stroke after 30 days, 0.90 (CI, 0.70 to 1.15) for mortality, and 0.90 (CI, 0.60 to 1.35) for HF hospitalization.LIMITATIONS: Clinical heterogeneity of trials, lack of participant-level data, and inclusion of unblinded trials.CONCLUSION: Catheter ablation reduced the risks for ischemic stroke at more than 30 days, mortality, and HF hospitalization. Surgical ablation had uncertain benefit, except for stroke.}, issn = {0003-4819} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_klementovtamara_2025, title = {Cefixime versus benzathine penicillin G for the treatment of early syphilis-a randomized, controlled open label trial}, author = {Klementová, Tamara and Zákoucká, Hana and Bížová, Beatrice and Unemo, Magnus and Rob, Filip}, year = {2025}, journal = {Journal of Antimicrobial Chemotherapy}, volume = {80}, number = {10}, pages = {2654--2658}, doi = {10.1093/jac/dkaf268}, url = {1990323}, language = {eng}, publisher = {Oxford University Press}, abstract = {OBJECTIVES: Cefixime is a promising oral treatment alternative for early syphilis but only very limited efficacy data exist. We evaluated the efficacy and safety of cefixime for the treatment of early syphilis.METHODS: A randomized controlled, open label trial in patients with confirmed early syphilis who were randomized to treatment with cefixime 400 mg orally twice a day for 14 consecutive days or to a single dose of benzathine penicillin G (BPG) 2.4 MIU intramuscular. The outcome was a 4-fold or more (≥2 dilution steps) decrease in Venereal Disease Research Laboratory test (VDRL) titre from baseline to 3 months (primary outcome) or 12 months (secondary outcome) after the treatment.RESULTS: Of 61 randomized patients, 58 (95.1%) completed the study (28 patients in the cefixime arm and 30 in the BPG arm). In the intention to treat analysis, the primary endpoint was achieved after 3 months in 22 of 30 (73.3%) of patients in the cefixime arm and 27 of 31 (87.1%) in the BPG arm, and after 12 months in 28 of 30 (93.3%) of patients in the cefixime arm and 30 of 31 (96.8%) of patients in the BPG arm. Both treatments were well tolerated and no serious adverse events or adverse events with severe intensity were reported.CONCLUSIONS: The results from our study are consistent with current limited knowledge and suggest that oral cefixime can be an effective and safe therapy for the treatment of early syphilis. However, additional efficacy data from larger treatment studies are imperative.}, issn = {0305-7453} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rajpiyush_2025, title = {Cell-TIMP : Cellular Trajectory Inference Based on Morphological Parameters}, author = {Raj, Piyush and Gupta, Himanshu and Anantha, Pooja and Barman, Ishan}, year = {2025}, journal = {Nano Letters}, volume = {25}, number = {19}, pages = {7845--7852}, doi = {10.1021/acs.nanolett.5c01009}, url = {1956069}, language = {eng}, publisher = {American Chemical Society (ACS)}, keywords = {cancer; cellular morphology; label-free imaging; quantitative phase imaging}, abstract = {Traditional approaches to studying cellular morphology rely on geometric metrics from stained images. However, staining processes can disrupt the cell's natural state and diminish accuracy due to photobleaching, while conventional analysis techniques, which categorize cells based on shape to discern pathophysiological conditions, often fail to capture the continuous and asynchronous nature of biological processes such as cell differentiation, immune responses, and cancer progression. In this work, we propose the use of quantitative phase imaging for morphological assessment due to its label-free nature. For analysis, we repurposed the genomic analysis toolbox to perform trajectory inference analysis purely based on morphology information. We applied the developed framework to study the progression of leukemia and breast cancer metastasis. Applying this framework to leukemia and breast cancer metastasis, we identified key shape changes linked to disease progression, highlighting the method's potential to enhance understanding of complex biological dynamics.}, issn = {1530-6984} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rablmiriam_2025, title = {Cerebrospinal fluid proteome alterations related to depressive symptoms in cognitive decline and Alzheimer's disease}, author = {Rabl, Miriam and Hartog, Willem L. and van der Flier, Wiesje M. and Pijnenburg, Yolande A. L. and Teunissen, Charlotte E. and Tsolaki, Magda and Freund-Levi, Yvonne and Vandenberghe, Rik and Froelich, Lutz and Streffer, Johannes and Lovestone, Simon and Bertram, Lars and Zetterberg, Henrik and Gobom, Johan and Vos, Stephanie J. B. and Visser, Pieter Jelle and Tijms, Betty M. and Popp, Julius}, year = {2025}, journal = {Alzheimer's & Dementia: Journal of the Alzheimer's Association}, volume = {21}, number = {12}, doi = {10.1002/alz.71054}, url = {2024488}, language = {eng}, publisher = {Sage Publications}, keywords = {alzheimer's disease; amyloid pathology; cerebrospinal fluid; cholesterol; depression; neuropsychiatric symptoms; proteomics}, abstract = {BACKGROUND: Depressive symptoms are common in cognitive decline and Alzheimer's disease (AD), but their underlying pathology remains poorly understood. We aimed to investigate the pathophysiology of depressive symptoms in the context of AD.METHODS: Individuals with normal cognition (NC), mild cognitive impairment (MCI), or mild AD dementia from two independent, large cohorts were included. Untargeted mass spectrometry-based cerebrospinal fluid (CSF) proteomics, regression analyses, and pathway-enrichment analyses were applied.RESULTS: A total of 688 individuals (223 NC, 190 MCI, and 275 AD dementia) were included. The levels of 57 out of 946 robustly quantified CSF proteins were associated with depressive symptoms consistently across both cohorts. These proteins were enriched for cell adhesion/inflammation, synaptic signaling, and neurogenesis. In amyloid-positive subjects, cholesterol metabolism and transport were additionally associated with depressive symptoms.CONCLUSION: The identified proteome alterations may reflect shared biological mechanisms involved in both AD and depression in older people. HIGHLIGHTS: This is the first study to investigate cerebrospinal fluid proteome alterations associated with depressive symptoms in the context of cognitive decline and Alzheimer's disease (AD). Dysregulated proteins in patients with higher depression scores were related to pathways linked to cell adhesion/inflammation, synaptic signaling, and neurogenesis, as well as cholesterol metabolism in amyloid-positive individuals. The identified proteome alterations may represent shared biological mechanisms involved in both AD and depression in older people.}, issn = {1552-5260} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vromeneleonoram_2025, title = {Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease}, author = {Vromen, Eleonora M. and Lageman, Senne B. and Gobom, Johan and van der Kant, Rik and Dobricic, Valerija and Bertram, Lars and Streffer, Johannes and Lovestone, Simon and Vos, Stephanie J. B. and Tainta, Mikel and Freund-Levi, Yvonne and Frölich, Lutz and Popp, Julius and Peyratout, Gwendoline and Tsolaki, Magda and Verhey, Frans and Vandenberghe, Rik and Schaeverbeke, Jolien and Blennow, Kaj and van der Lee, Sven J. and Scheltens, Philip and Pijnenburg, Yolande A. L. and van der Flier, Wiesje M. and Teunissen, Charlotte E. and Zetterberg, Henrik and Visser, Pieter Jelle and Tijms, Betty}, year = {2025}, journal = {Alzheimer's & Dementia: Journal of the Alzheimer's Association}, volume = {21}, number = {10}, doi = {10.1002/alz.70738}, url = {2006621}, language = {eng}, publisher = {Sage Publications}, keywords = {alzheimer's disease; apolipoprotein e; cerebrospinal fluid; cognitively normal; mild cognitive impairment; protection; proteomics; risk}, abstract = {BACKGROUND: The apolipoprotein E (APOE) gene includes the strongest protective (ε2) and risk (ε4) variants for sporadic Alzheimer's disease (AD), but underlying mechanisms remain unclear. We studied APOE genotype effects on the cerebrospinal fluid (CSF) proteome.METHODS: Using untargeted tandem mass tag mass spectrometry, we analyzed CSF from 227 cognitively normal (CN) controls (A-T-), 165 CN A+, and 177 individuals with mild cognitive impairment (MCI A+) from two large cohorts. We compared protein levels across APOE genotypes using linear regression and characterized biological pathways. RESULTS: Five hundred forty-nine of 978 proteins (56%) differed between ε2/ε3 (n = 32 individuals) or ε4 carriers (n = 181 individuals) and ε3/ε3 controls. ε2/ε3 controls showed the most differences, with higher levels of 280 proteins enriched for neuronal plasticity. ε4 carrier controls showed increased proteins linked to blood-brain barrier dysfunction, and A+ ε4 carriers were related to glucose metabolism.DISCUSSION: Combining two cohorts enabled analysis of the rare APOE ε2 genotype, suggesting protective effects may occur through improved neuronal plasticity.HIGHLIGHTS: Apolipoprotein E (APOE) genotypes show distinct cerebrospinal fluid proteomic mechanisms in early Alzheimer's disease (AD). Combining cohorts enabled analysis of rare APOE ε2-associated protection in AD. The rare ε2 genotype may confer protection through improved neuronal plasticity. APOE ε4 carriers show increased blood-brain barrier dysfunction and glucose metabolism. These findings offer new insights into genotype-specific mechanisms in early AD.}, issn = {1552-5260} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_delvenneaurore_2025, title = {Cerebrospinal fluid proteomic profiling of cognitively unimpaired individuals with suspected non-Alzheimer's disease pathophysiology}, author = {Delvenne, Aurore and Gobom, Johan and Reus, Lianne M. and Dobricic, Valerija and ten Kate, Mara and Schindler, Suzanne E. and Ramakers, Inez and Tijms, Betty M. and Vandenberghe, Rik and Schaeverbeke, Jolien and Martinez-Lage, Pablo and Tainta, Mikel and Teunissen, Charlotte E. and Popp, Julius and Peyratout, Gwendoline and Tsolaki, Magda and Freund-Levi, Yvonne and Lovestone, Simon and Streffer, Johannes and Barkhof, Frederik and Bertram, Lars and Blennow, Kaj and Zetterberg, Henrik and Visser, Pieter Jelle and Vos, Stephanie J. B.}, year = {2025}, journal = {Brain Communications}, volume = {7}, number = {4}, doi = {10.1093/braincomms/fcaf253}, url = {1986039}, language = {eng}, publisher = {Oxford University Press}, keywords = {suspected non-alzheimer's disease pathophysiology; cognitively unimpaired; biomarkers; tau; proteomics}, abstract = {Suspected non-Alzheimer's disease pathophysiology (SNAP) is a biomarker-based concept describing individuals with abnormal tau and/or neurodegeneration markers but normal amyloid levels. SNAP is common in individuals with normal cognition (NC), but its underlying pathophysiology is understudied, while being relevant for clinical trial design and treatment approaches. We aimed to investigate the pathophysiology of individuals with NC who are amyloid-negative and tau-positive (SNAP) through cerebrospinal fluid (CSF) proteomics. Two hundred and ninety-one individuals with NC were classified based on CSF amyloid beta 1-42 and phosphorylated tau 181, as amyloid-negative/tau-negative (controls), amyloid-negative/tau-positive (SNAP), amyloid-positive/tau-negative and amyloid-positive/tau-positive. We measured 3102 proteins in CSF using tandem mass tag proteomic analyses. We compared protein abundance between groups using analysis of covariance and identified enriched biological pathways using Gene Ontology. We also examined differences between groups in genetic risk for Alzheimer's disease, estimated using polygenic risk scores based on genome-wide association study data. SNAP individuals with NC showed mostly increased protein levels (n = 360) compared with controls, mainly associated with neuroplasticity, angiogenesis, and protein modification and degradation. The proteomic profile of SNAP was similar to that of amyloid-positive/tau-positive individuals, while distinct from amyloid-positive/tau-negative individuals, who showed mainly decreased proteins associated with neuroplasticity. Higher levels of amyloid beta 1-40 and amyloid beta 1-42 were observed in SNAP compared with the three other groups. Polygenic risk scores analyses showed no significant differences between SNAP, amyloid-positive/tau-negative, and amyloid-positive/tau-positive individuals, while SNAP showed some genetic differences from controls, which were driven by APOE. Individuals with NC and SNAP or amyloid-positive/tau-positive status showed similar CSF proteomic profiles, while amyloid-positive/tau-negative individuals showed a distinct CSF proteomic profile. This suggests that tau, rather than amyloid, might be the main driver of the proteomic profiles in SNAP and other amyloid/tau subgroups. This may have implications for future proteomic studies and clinical trial design, as these findings highlight the importance of considering tau status in future studies. Suspected non-Alzheimer's disease pathophysiology (SNAP) refers to individuals with abnormal tau but normal amyloid. Delvenne et al. investigated the pathophysiology of SNAP in cognitively unimpaired individuals using cerebrospinal fluid proteomics and found that SNAP individuals exhibit increased neuroplasticity proteins, similar to those in Alzheimer's disease, suggesting that tau drives these changes.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_heleniusgisela_2025, title = {Cervical screening with self-sampling for postmenopausal women with molecular triage using extended genotyping and methylation}, author = {Helenius, Gisela and Lillsunde-Larsson, Gabriella and Karlsson, Mats G. and Kaliff, Malin and Bergengren, Lovisa}, year = {2025}, journal = {European Journal of Obstetrics, Gynecology, and Reproductive Biology}, volume = {305}, pages = {404--409}, doi = {10.1016/j.ejogrb.2024.12.056}, url = {1925947}, language = {eng}, publisher = {Elsevier}, keywords = {cervical screening; cytology; hpv; high-grade squamous intraepithelial lesion; molecular triage; postmenopausal women; self-sampling}, abstract = {OBJECTIVE: With the transition from cytology to human papilloma virus (HPV) testing in cervical cancer screening, it is possible to use self-sampling instead of professionally collected samples. Most studies have included women between 20 and 60 years age. Here we aimed to study postmenopausal women and investigate whether vaginal self-sampling is equally effective as professional sampling for detection of HSIL and the possibility to use a method for molecular triage directly on the screening sample.METHODS: Postmenopausal women in Örebro county, Sweden, were invited (n = 7835) during 2018-2020 to participate in the study including both professional and self-sampling. In total 2258 women returned both sample types, that were analyzed for HPV followed by triage for cytology, HPV genotyping and methylation and clinical follow-up according to national guidelines.RESULTS: The prevalence of HPV was 3.4 % in the professionally collected samples and 12.6 % in the self-collected. All women with high-grade squamous intraepithelial lesion (HSIL) were HPV-positive in both professionally and self-collected samples. For self-collected samples, we compared different triage strategies. Cytology was the most efficient strategy. Among the molecular triage methods, the combination of methylation and genotyping was most efficient but resulted in twice as many colposcopy referrals as cytology.CONCLUSIONS: In conclusion, HPV self-sampling with molecular triage detects HSIL to the same extent as professional screening with cytological triage. The specificity of molecular triage is, however, unacceptably low, and to avoid overtreatment other triage methods following primary self-sampling need to be developed.}, issn = {0301-2115} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kotschikpia_2025, title = {Challenges and opportunities for the environmental risk assessment of chemicals in soils : a recap and follow-up of a setac webinar}, author = {Kotschik, Pia and Renaud, Mathieu and Princz, Juliska and Rijk, I. J. C. and Menke, Ulrich and Brooks, Bonnie and Pieper, Silvia and van Gestel, Cornelis A. M. and Vieira, Diana and Silva, Vera and Russell, David and da-Luz, Tiago Natal- and Lima, Claudia and Grenni, Paola}, year = {2025}, journal = {Integrated Environmental Assessment and Management}, doi = {10.1093/inteam/vjaf102}, url = {1990401}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {soil health; chemicals; pesticides; risk assessment framework; terrestrial ecotoxicology}, abstract = {Soil sustainability is unquestionable but is under various threats, one of which includes chemical pollution. Under the vision of reaching healthy soils by 2050, the SETAC Webinar "Assessing Risks in Soil: Challenges and Opportunities" was held to understand the current state of soil health in Europe and, identify gaps in the environmental risk assessment (ERA) framework for chemicals entering soils. In reflection of the webinar and soil protection, strategies to describe the current state of soils, including knowledge on existing chemical pollution in soils and soil biodiversity metrics are discussed. With respect to soil pollution by chemicals, the current ERA framework was analysed to identify gaps and needs to protect in-soil biodiversity exposed to chemicals. Here, the importance of soil monitoring and cyclical feedback mechanisms for ERA is highlighted as well as the need to shift the current ERA framework towards a holistic approach that considers long-term impacts on in-soil organisms and soil biodiversity under realistic conditions. Two methods (terrestrial model ecosystems and trait-based approaches) are reviewed as potential suitable tools for the detection of community level effects within the ERA of chemicals entering soils. Finally, the need for cooperation and engagement between member states and stakeholders is tabled.}, issn = {1551-3777} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_ravikumarr_2025, title = {Challenges and Risk Assessment of Nanomaterial-based Chemicals Used for Sustainable Agriculture}, author = {Ravikumar, R. and Jayavardhini, M. and Sai, Sidharth A. and Rajulapati, Vikky and Saynik, P.B.}, year = {2025}, pages = {377--394}, doi = {10.1002/9783527849949.ch14}, url = {2029747}, language = {eng}, publisher = {Wiley-VCH Verlagsgesellschaft}, keywords = {ethical concerns; nanofertilizers; nanoherbicides; nanopesticides; nanotoxicology; regulations; risk assessment; risk management; sustainable agriculture}, abstract = {Driven by the exponential growth in population, new agricultural practices are being explored and adopted to accommodate the increasing food needs. This demands the increased usage of fertilizers to ensure good crop yield. However, the enhanced usage of conventional fertilizers could pose environmental, health, and soil impacts. Nanofertilizers prove to be an excellent alternative to traditional fertilizers. Despite being the next generation of agrochemicals, nanoparticles require a thorough risk assessment before being implemented for agricultural applications. Therefore, practical risk assessment and management are essential to ensure a seamless transition. Concerns exist regarding the potential environmental and health risks associated with the use of nanofertilizers. In response, global regulatory organizations have created policies and guidelines to guarantee the safe application of nanotechnology in agricultural goods. This chapter covers in detail the nanofertilizers and nanopesticides, risks, challenges, and uncertainties associated with them, risk management, regulation and safety measures, as well as ethical concerns and public perceptions.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_figaroaorlane_2025, title = {Challenges in Follow-up After Kidney-sparing Surgery for Upper Tract Urothelial Carcinoma : Insights from a Delphi Consensus}, author = {Figaroa, Orlane and Schuil, Hugo and Kamphuis, Guido and van den Brink, Luna and Hendriks, Nora and Henderickx, Michaël and Bins, Adriaan and van Moorselaar, Jeroen and Ajayi, Leye and Bus, Mieke and Cavadas, Vitor and Cracco, Cecilia Maria and Andrea, David D. and Dasgupta, Ranan and Coninck, Vincent De and Durutovic, Otas and Ebbensgaard, Ida and Ferretti, Stefania and Gallioli, Andrea and Keller, Etienne Xavier and Keeley, Francis Xavier and Sloth Osther, Palle Jörn and Popiolek, Marcin and Pradere, Benjamin and Proietti, Silvia and Saltirov, Iliya and Somani, Bhaskar and Tailly, Thomas and Thomas, Kay and Turney, Ben and Ulvik, Øyvind and Haute, Carl Van and van der Heij, Bart and Vasquez, Juan Luis and Brehmer, Marianne and Baard, Joyce}, year = {2025}, journal = {European Urology Oncology}, volume = {8}, number = {5}, pages = {1303--1310}, doi = {10.1016/j.euo.2025.07.003}, url = {1991201}, language = {eng}, publisher = {European Association of Urology}, keywords = {delphi consensus; follow-up; kidney-sparing surgery; upper tract urothelial carcinoma; ureteroscopy}, abstract = {BACKGROUND AND OBJECTIVE: Kidney-sparing surgery (KSS) is the preferred treatment for patients with low-risk upper tract urothelial carcinoma (UTUC), offering a balance between oncologic efficacy and renal preservation. However, follow-up protocols are lacking due to insufficient evidence, resulting in clinical variability. In response, a Delphi consensus process has been initiated with the aim to refine and establish unified surveillance recommendations following KSS for low-risk UTUC.METHODS: A multistage Delphi consensus project was conducted by an expert panel, which completed four rounds of questionnaires using both open-ended and Likert scale-based questions, with the goal of achieving consensus on four key topics.KEY FINDINGS AND LIMITATIONS: In total, 28 invited experts participated in the Delphi panel, achieving consensus on the primary goals of UTUC follow-up, including tumour recurrence detection, renal function preservation, and maintaining quality of life. While consensus was reached on key diagnostic modalities (kidney function, computed tomography urography, cystoscopy, and ureteroscopy) and follow-up adjustments based on treatment indications, the precise schedules and long-term follow-up duration remained unresolved.CONCLUSIONS AND CLINICAL IMPLICATIONS: This Delphi project underscores the challenges of standardising follow-up protocols after KSS for UTUC. A balanced approach is needed to ensure early recurrence detection while preserving renal function and quality of life. Robust data on prognostic factors are essential to better identify patients at risk of recurrence and to refine surveillance strategies. Collaborative research remains essential for developing evidence-based follow-up protocols for this rare disease.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_schenklinda_2025, title = {Challenges to estimating and managing risks with hexavalent chromium exposure : a mixed-methods study of Swedish workplaces}, author = {Schenk, Linda and Engfeldt, Malin and Tinnerberg, Håkan and Ricklund, Niklas and Tondel, Martin and Wiebert, Pernilla and Albin, Maria and Broberg, Karin}, year = {2025}, journal = {Annals of Work Exposures and Health}, volume = {69}, number = {7}, pages = {722--735}, doi = {10.1093/annweh/wxaf039}, url = {1982388}, language = {eng}, publisher = {Oxford University Press}, keywords = {bath plating; carcinogens; mutagens and reprotoxic substances directive; occupational exposure limit values; steel production; welding}, abstract = {Using a mixed-methods approach, we assessed understanding of risks from exposure to the non-threshold carcinogen hexavalent chromium (Cr(VI)) among workers (n = 113) and occupational health and safety managers (n = 13) at 14 worksites with potential exposure to Cr(VI). We found that 55% of the workers had a measurable concentration of inhalable Cr(VI), with 19% exceeding 1 µg/m3, a level that corresponds to an "upper risk level" for future EU binding occupational exposure limits over a working lifetime. Additionally, 52% of workers had red blood cell (RBC) Cr concentrations exceeding the 95th percentile of an unexposed control group. Among responding workers (n = 91), 35% reported to perceive to be at no or low risk due to Cr(VI) exposure, 47% to be at some or large risk while 18% stated to be unsure. No correlations were found between reported risk perceptions and measured inhalable Cr(VI), urinary Cr, or RBC-Cr, but a weak correlation to years employed was found. Observations indicated that the hierarchy of controls was not strictly followed. Furthermore, 42% of respiratory protective equipment users used it incorrectly, and only two out the 50 (4%) needing a fit-test reported having performed one. Interviews with the managers revealed a lack of knowledge about the health risks of Cr(VI), and that expectations about exposure levels did not always match measured exposures. Our findings identify knowledge gaps regarding the health hazards of Cr(VI) and highlight the difficulty of estimating workplace exposure and risk without measurements. Based on our findings we recommend efforts to improve knowledge about Cr(VI) health hazards, strengthen the adherence to the hierarchy of controls, and incentivize quantitative exposure assessments.}, issn = {2398-7308} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_kondylivasiliki_2025_1, title = {Change Blindness and Anticipation in Naturalistic Driving : The Role of Visuospatial and Temporal Complexity}, author = {Kondyli, Vasiliki and Bhatt, Mehul}, year = {2025}, url = {2024228}, language = {eng}, keywords = {change blindness; visual search; anticipation; environmental complexity; naturalistic observation; attentional strategies; driver education}, abstract = {Everyday driving relies on cognitive functions such as visual search, change detection and predictive attention for maintaining a high-level mental model of the world. Such functions are especially constrained by limited cognitive resources under complex conditions. Understanding the manner in which environmental complexity influences cognitive driving performance is key to improving road safety and developing human-factors guided driver assistance systems. Towards this, we explore the relationship between visuospatial and temporal complexity, and drivers’ situational awareness and decision-making. Particularly, we address two research questions: (I) How environmental complexity (visuospatial and temporal) impacts (in)attentional blindness; and (II) How does visual cueing impact anticipatory attention. In a naturalistic VR study, 150 participants drove in an immersive urban environment with varying complexity levels while responding to conditions such as overtaking, pedestrian crossings, occlusions, safety-criticality. The experiment, rooted to real-world driving data, incorporates a systematic cognitive model of environmental complexity consisting of dynamic visual, spatial, multimodal interaction features. Furthermore, we also analyse multimodal behavioural data, including gaze patterns, head movements, steering and braking. Results show that: (1) High visuospatial complexity increases inattentional blindness, with drivers compensating by prioritizing critical events; (2) Temporal complexity impairs detection performance, especially when events occur in rapid succession (1 sec) or when they last 5-10 seconds; and (3) Visual cueing improves anticipation, detection performance, and reaction time. These findings highlight the importance of adaptive strategies in overcoming cognitive limitations, providing insights for designing safety systems and training protocols for improving or assessing driver performance in everyday driving environments.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sarneckijerzy_2025, title = {Changes in Immigrant Population Prevalence and High Violent Crime Rates in Swedish Municipalities}, author = {Sarnecki, Jerzy and Beckley, Amber L. and Wikman, Sofia and Westfelt, Lars and Lilja, My and Mondani, Hernan and Bäcklin, Emy and Rostami, Amir}, year = {2025}, journal = {Journal of International Migration and Integration}, volume = {26}, pages = {1223--1243}, doi = {10.1007/s12134-024-01221-1}, url = {1929761}, language = {eng}, publisher = {Springer}, keywords = {immigration; violence; europe; sweden; macro-level}, abstract = {Global evidence indicates minimal connection between immigration and crime. Nordic research, however, has been generally carried out on individuals and shows that immigrants are over-represented in crime. This has led to claims that high crime rates are due to immigration. We directed our study towards these claims by analyzing immigrant population prevalence, defined as the percent of foreign-born individuals, and violent crime in Swedish municipalities between 2000 and 2020. Nearly all municipalities had higher violent crime rates in 2020 relative to 2000. To discern whether drastic increases in municipality-level crime rates could be connected to municipality-level immigrant population prevalence, a retrospective case-control design was used to select 20 municipalities with the highest increase in reported violent crime rates and 20 municipalities with the lowest increase in reported violent crime rates. Immigrant population prevalence had little association with high rates of reported violent crime. The average association between immigrant population prevalence and violent crime rates calculated from all municipalities was also weak and non-significant (p > 0.05). Municipalities with a high increase in crime tended to have more crime correlates than municipalities with a low increase in crime. However, more research is needed on the impact of migration in small towns, especially those that have experienced economic and social stagnation.}, issn = {1488-3473} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_skoogper_2025, title = {Changes in Sex Related Mortality after Revascularisation for Chronic Limb Threatening Ischaemia : A National Observational Study 1994 - 2018}, author = {Skoog, Per and Larsson, Henrik and Magnuson, Anders and Troëng, Thomas and Norgren, Lars}, year = {2025}, journal = {European Journal of Vascular and Endovascular Surgery}, volume = {69}, number = {1}, pages = {130--137}, doi = {10.1016/j.ejvs.2024.08.046}, url = {1895663}, language = {eng}, publisher = {Elsevier}, keywords = {chronic limb threatening ischaemia; longitudinal studies; mortality; revascularisation}, abstract = {OBJECTIVE: The aim of this study was compare all cause mortality across three time periods with a focus on sex differences after revascularisation for chronic limb threatening ischaemia between 1994 and 2013 in Sweden.METHODS: In this observational registry study, patients registered in the Swedish vascular registry (Swedvasc), revascularised between 1994 and 2013 with open or endovascular infra-inguinal procedures, were divided into three time periods: 1994 - 1999, 2000 - 2006, and 2007 - 2013. Patients were followed for five years. Poisson regression was used to compare 30 day mortality, presented as adjusted relative risk ratio (aRR). Adjusted restricted mean survival time (aRMST) differences at five years were compared with a generalised linear model. The analyses were adjusted for age, comorbidities, and endovascular or open surgery. Comparison with the general Swedish population was also conducted with age adjusted standardised mortality ratios. Results are presented with the 95% confidence intervals (CI).RESULTS: The study showed increasing 30 day mortality, with an aRR of 1.47 (95% CI 1.31 - 1.65) for women and aRR of 1.20 (95% CI 1.06 - 1.35) for men, per time period. In women, the five year RMST decreased from the first to the third period, with an aRMST of -45 (95% CI -59 - -32) days per period. In men, the aRMST increased 32 (95% CI 18 - 47) days per period. When comparing sexes, women showed lower 30 day mortality and higher five year survival than men in the first time period, but a significantly worse development over time periods than for men. Corresponding findings were observed in comparison with the general Swedish population.CONCLUSION: This study showed an increased 30 day mortality in women and men across the periods, most evident in women. Men showed an increased five year survival across the periods, whereas opposite findings were recorded for women. The dismal trend over time for women could not be explained by increased age or a higher prevalence of comorbidities.}, issn = {1078-5884} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_luohongyi_2025, title = {Channel-Robust RF Fingerprint Identification for Multi-Antenna 5G User Equipments}, author = {Luo, Hongyi and Li, Guyue and Brighente, Alessandro and Conti, Mauro and Xing, Yuexiu and Hu, Aiqun and Wang, Xianbin}, year = {2025}, journal = {IEEE Transactions on Information Forensics and Security}, volume = {20}, pages = {10761--10776}, doi = {10.1109/TIFS.2025.3611154}, url = {2012691}, language = {eng}, publisher = {IEEE}, keywords = {5g mobile communication; radio frequency; feature extraction; object recognition; authentication; antennas; training; downlink; uplink; signal to noise ratio; physical-layer security; radio frequency fingerprint; device identification; multipath channels}, abstract = {Radio frequency fingerprint (RFF) is a promising solution for realizing secure and efficient device identification. However, the accuracy of currently existing solutions suffer from multipath effects in practical scenarios. In this paper, we provide a robust RFF identification method that leverages channel state information (CSI) feedback to counteract the effect of the channel on the extracted RFF features. A straightforward zero-forcing (ZF) equalization fails to fully decouple RF impairments from the channel, making conventional approaches ineffective. To overcome this challenge, we utilize the potential of multi-antenna and introduce a new device-specific feature called Relative-RFF (R-RFF), which represents the relation between different RF chains in a multi-antenna transmitter. We propose an enhanced ZF post-equalization algorithm to eliminate the multipath channels and preserve the users' R-RFF to the greatest extent. We evaluate the robustness of R-RFF under various channel conditions and noise levels and the performance of R-RFF in terms of identification accuracy under different channel scenarios. The results show that the proposed R-RFF method can achieve an identification accuracy of 91.2% for 70 devices in tapped delay line channel with a signal-to-noise ratio (SNR) of 30 dB.}, issn = {1556-6013} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_grnnolle_2025, title = {Characterising the Phases of Inflammatory Bowel Disease : From Genetic Predisposition to Established Disease}, author = {Grännö, Olle}, year = {2025}, url = {1942084}, language = {eng}, publisher = {Örebro University}, abstract = {Background: Inflammatory bowel disease (IBD) is a common and lifelong condition, but the phases of IBD development remain poorly understood.Aims and methods: We aimed to characterise the distinct phases of IBD, encompassing (1) genetic predisposition, (2) preclinical disease, (3) diagnosis, (4) early disease course, and (5) established disease. To this end, we used twin methodology, proteomic profiling and characterisation of the gut microbiome.Results: In Study I, the heritability was estimated to be 0.78 for Crohn’s disease (CD) and 0.57 for ulcerative colitis (UC). Study II identified protein signatures capable of predicting a future diagnosis of CD (area under the curve [AUC] = 0.77) and UC (AUC = 0.67). Study III revealed a restricted diagnostic potential of gut microbiome signatures for CD (AUC = 0.62) and UC (AUC = 0.59). Study IV yielded a risk score that could predict the future disease course of patients with newly diagnosed UC (AUC = 0.77). Study V was a longitudinal investigation of patients with ileal CD. We observed a negative correlation between temporal changes in the relative abundance of the commensal bacteria Faecalibacterium prausnitzii and changes in faecal calprotectin levels (R = -0.39; p = .009).Conclusions:1. A strong genetic predisposition to IBD is evident, with markedly higher heritability observed in CD relative to UC.2. The circulating proteome can be used to prognosticate CD more than 16 years before its diagnosis.3. The mucosa-associated gut microbiome's diagnostic capacity seems limited.4. A proteomics-based risk score offers a means of predicting the early disease course of UC.5. Temporal changes in the relative abundance of F. prausnitzii are associated with changes in inflammatory activity in ileal CD.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hoffleonardosantos_2025, title = {Characteristics and risk factors of COVID-19 breakthrough infections in Idiopathic Inflammatory Myopathies : Results from the COVAD study}, author = {Hoff, Leonardo Santos and Parodis, Ioannis and Gupta, Latika}, year = {2025}, journal = {Rheumatology}, volume = {64}, number = {2}, pages = {597--606}, doi = {10.1093/rheumatology/keae128}, url = {1842270}, language = {eng}, publisher = {Oxford University Press}, keywords = {covid-19; autoimmune diseases; breakthrough infection; hospitalisation; idiopathic inflammatory myopathies}, abstract = {OBJECTIVES: To explore prevalence, characteristics and risk factors of COVID-19 breakthrough infections (BIs) in idiopathic inflammatory myopathies (IIM) using data from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study.METHODS: A validated patient self-reporting e-survey was circulated by the COVAD study group to collect data on COVID-19 infection and vaccination in 2022. BIs were defined as COVID-19 occurring ≥14 days after 2 vaccine doses. We compared BIs characteristics and severity among IIMs, other autoimmune rheumatic and non-rheumatic diseases (AIRD, nrAID), and healthy controls (HC). Multivariable Cox regression models assessed the risk factors for BI, severe BI and hospitalisations among IIMs.RESULTS: Among 9449 included response, BIs occurred in 1447 (15.3%) respondents, median age 44 years (IQR 21), 77.4% female, and 182 BIs (12.9%) occurred among 1406 IIMs. Multivariable Cox regression among IIMs showed age as a protective factor for BIs [Hazard Ratio (HR)=0.98, 95%CI = 0.97-0.99], hydroxychloroquine and sulfasalazine use were risk factors (HR = 1.81, 95%CI = 1.24-2.64, and HR = 3.79, 95%CI = 1.69-8.42, respectively). Glucocorticoid use was a risk factor for severe BI (HR = 3.61, 95%CI = 1.09-11.8). Non-White ethnicity (HR = 2.61, 95%CI = 1.03-6.59) was a risk factor for hospitalisation. Compared with other groups, patients with IIMs required more supplemental oxygen therapy (IIM = 6.0% vs AIRD = 1.8%, nrAID = 2.2%, and HC = 0.9%), intensive care unit admission (IIM = 2.2% vs AIRD = 0.6%, nrAID, and HC = 0%), advanced treatment with antiviral or monoclonal antibodies (IIM = 34.1% vs AIRD = 25.8%, nrAID = 14.6%, and HC = 12.8%), and had more hospitalisation (IIM = 7.7% vs AIRD = 4.6%, nrAID = 1.1%, and HC = 1.5%).CONCLUSION: Patients with IIMs are susceptible to severe COVID-19 BI. Age and immunosuppressive treatments were related to the risk of BIs.}, issn = {1462-0324} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sivanderanna_2025, title = {Characteristics related to biomarkers of neutrophil, eosinophil, and mast cell activation}, author = {Sivander, Anna and Hårdstedt, Maria and Nerpin, Elisabet and Movérare, Robert and Sjölander, Anders and Janson, Christer and Malinovschi, Andrei}, year = {2025}, journal = {Scientific Reports}, volume = {15}, number = {1}, doi = {10.1038/s41598-025-18398-9}, url = {2004394}, language = {eng}, publisher = {Nature Portfolio}, keywords = {biomarkers; eosinophil; neutrophil; mast cell; disease}, abstract = {Systemic inflammation is important in many medical conditions. Activation markers of inflammatory cells can be quantified, but are less studied. Therefore, we studied individual characteristics and diseases in relation to neutrophil gelatinase-associated lipocalin (NGAL) and myeloperoxidase (MPO), both for neutrophils, eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), and mast cell tryptase. Spirometry and serum biomarkers were assessed in 498 participants (252 males) aged >= 40 years from the Uppsala center of the population-based Burden of Obstructive Lung Disease study. Higher MPO, NGAL and EDN levels related to heart disease. Higher ECP and EDN levels were both related to asthma while higher EDN related to male sex and atopy. Higher tryptase levels were found in subjects with obesity, chronic airflow limitation (CAL), or hypertension. In multivariate analyses, subjects with heart disease had 22.1% (95% confidence interval 4.1%, 43.3%) higher MPO, 19.3% (7.8%, 31.9%) higher NGAL, and 23.2% (3.0%, 47.3%) higher EDN than subjects without heart disease. The association between CAL and tryptase was not consistent after adjustment for age and BMI as continuous variables. The higher EDN levels in heart disease is a novel finding that require further studies to elucidate the clinical importance.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ahlbergemelie_2025, title = {Characterization of Extracellular Vesicles From Fresh vs. Frozen Human Milk Including the Vesicular microRNA Cargo}, author = {Ahlberg, Emelie and Al-Kaabawi, Ahmed and Eldh, Maria and Gabrielsson, Susanne and Jenmalm, Maria C. and Tingö, Lina}, year = {2025}, journal = {Journal of extracellular biology}, volume = {4}, number = {10}, doi = {10.1002/jex2.70092}, url = {2006419}, language = {eng}, publisher = {Co-Action Publishing}, keywords = {characterization; exosomes; extracellular vesicles; freezing; human milk; microrna; sodium citrate; storage condition}, abstract = {Human milk is rich in extracellular vesicles (EV) that may contribute to shaping neonatal immunity. Here, we evaluated whether freezing, and the addition of sodium citrate (SC), affect the characteristics of human milk EVs and their miRNAs. Freezing may compromise the milk EV population and their miRNA profile by creating artificial vesicles due to cell lysis. Furthermore, SC can be added to clear the EV fraction of micelles, that is, protein aggregates that co-isolate with milk EVs, and may affect certain downstream analyses. To investigate potential differences between milk EV and their miRNA cargo when isolated from fresh and frozen samples, mature milk samples were collected from 10 women and subjected to four different treatments: fresh and frozen; freshSC and frozenSC. Ultracentrifugation was used for EV isolation, and subsequently characterized by Nanoparticle tracking analysis, flow cytometry, Western blot and electron microscopy. While freezing without SC has no impact on the evaluated EV parameters, freezing with SC significantly altered particle mean size as measured by NTA and protein levels as studied by MACSPlex flow cytometry. Importantly, neither freezing nor SC had an impact on the EV miRNA cargo, measured by qPCR. These findings also suggest that EV isolates from frozen samples, in comparison to freshly isolated ones, can produce valid results concerning morphology, size, surface markers and the EV miRNA profile.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_salomonbenita_2025, title = {Characterization of Inflammatory Bowel Disease Heterogeneity Using Serum Proteomics : A multicenter study}, author = {Salomon, Benita and Sudhakar, Padhmanand and Bergemalm, Daniel and Andersson, Erik and Grännö, Olle and Carlson, Marie and Hedin, Charlotte R. H. and Söderholm, Johan D. and Öhman, Lena and Lindqvist, Carl Mårten and Kruse, Robert and Repsilber, Dirk and Verstockt, Bram and Vermeire, Séverine and Halfvarson, Jonas}, year = {2025}, journal = {Journal of Crohn's & Colitis}, volume = {19}, number = {5}, doi = {10.1093/ecco-jcc/jjae169}, url = {1910636}, language = {eng}, publisher = {Oxford University Press}, keywords = {biomarkers; crohn's disease; montreal classification; ulcerative colitis; disease location; serum proteins}, abstract = {BACKGROUND: Recent genetic and transcriptomic data highlight the need for improved molecular characterisation of inflammatory bowel disease (IBD). Proteomics may advance the delineation of IBD phenotypes since it accounts for post-transcriptional modifications. AIM: We aimed to assess the IBD spectrum based on inflammatory serum proteins and identify discriminative patterns of underlying biological subtypes across multiple European cohorts.METHODS: Using proximity extension methodology, we measured 86 inflammation-related serum proteins in 1551 IBD patients and 312 healthy controls (HC). We screened for proteins exhibiting significantly different levels among IBD subtypes and between IBD and HC. Classification models for differentiating between Crohn's disease (CD) and ulcerative colitis (UC) were employed to explore the IBD spectrum based on estimated probability scores.RESULTS: Levels of multiple proteins, such as IL-17A, MMP-10, and FGF-19, differed (fold-change>1.2; FDR<0.05) between ileal vs colonic IBD. Using multivariable models, a protein signature reflecting the IBD spectrum was identified, positioning colonic CD between UC and ileal CD, which were at opposite ends of the spectrum. Based on area under the curve (AUC) estimates, classification models more accurately differentiated UC from ileal CD (median AUCs>0.73) than colonic CD (median AUCs<0.62). Models differentiating colonic CD from ileal CD demonstrated intermediate performance (median AUCs 0.67-0.69).CONCLUSION: Our findings in serum proteins support the presence of a continuous IBD spectrum rather than a clear separation of CD and UC. Within the spectrum, disease location may reflect a more similar disease than CD vs UC, as colonic CD resembled UC more closely than ileal CD.}, issn = {1873-9946} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_omerabubakr_2025, title = {Characterization of Novel Plantaricin-Derived Antiviral Peptides Against Flaviviruses}, author = {Omer, Abubakr and Kumar, Sanjiv and Selegård, Robert and Bengtsson, Torbjörn and Khalaf, Hazem}, year = {2025}, journal = {International Journal of Molecular Sciences}, volume = {26}, number = {3}, doi = {10.3390/ijms26031038}, url = {1937960}, language = {eng}, publisher = {MDPI}, keywords = {west nile virus; antiviral; flaviviruses; molecular docking; plantaricin; zika virus}, abstract = {Flaviviruses, including West Nile virus, Zika virus, and Dengue virus, pose global health challenges due to their distribution, pathogenicity, and lack of effective treatments or vaccines. This study investigated the antiviral activity of novel truncated peptides derived from the two-peptide plantaricins PLNC8 αβ, PlnEF, PlnJK, and PlnA. The antiviral potential was predicted using machine learning tools, followed by in vitro evaluation against the Kunjin virus using plaque reduction assays in Vero cells. Molecular docking assessed peptide interactions with KUNV and ZIKV. Full-length and truncated peptides from PlnA, PlnE, PlnF, PlnJ, and PlnK demonstrated limited antiviral efficacy against KUNV in vitro, despite in silico predictions suggesting antiviral potential for PlnA, PlnE, and PlnJ. Large discrepancies were observed between the predicted and experimentally determined activities. However, complementary two-peptide plantaricins PlnEF and PlnJK exhibited significant synergistic effects. Furthermore, the truncated peptides PLNC8 α1-15 and PLNC8 β1-20 reduced KUNV viral load by over 90%, outperforming their full-length counterparts. Molecular docking revealed interactions of PLNC8 α and PLNC8 β, and their truncated variants, with KUNV and ZIKV, suggesting a mechanism involving viral envelope disruption. These findings highlight the potential of plantaricin-derived peptides as promising antiviral candidates against flaviviruses, warranting further investigation into their mechanisms and applications.}, issn = {1661-6596} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nassazziw_2025, title = {Characterization of per- and polyfluoroalkyl substances (PFAS) in willow and poplar and the impact of soil amendments on accumulation rates}, author = {Nassazzi, W. and Bezabhe, Yared and Guo, C. and Tapase, S. and Jaffe, B.D. and Key, T.A. and Lai, F.Y. and Jass, Jana and Ahrens, L.}, year = {2025}, journal = {Environmental Technology & Innovation}, volume = {37}, doi = {10.1016/j.eti.2025.104048}, url = {2028254}, language = {eng}, publisher = {Elsevier}, keywords = {microbial community; phytoextraction; phytohydraulics; phytostabilization; populus trichocarpa; salix miyabeana}, abstract = {Phytoremediation technologies have the potential to be cost-effective solutions for managing per- and polyfluoroalkyl substances (PFAS). In this greenhouse study, we assessed the uptake of PFAS using two plant species commonly used for phytoremediation, Salix miyabeana (willow) and Populus trichocarpa (poplar). We also assessed the impact of a commercially available growth phytohormone (naphthalene acetic acid (NAA)) and a microbial amendment on plant growth and PFAS uptake. Overall, uptake was observed, depending on perfluorocarbon chain length and functional group. After 90 days, the uptake of individual PFAS in plants grown in PFAS contaminated soil ranged from 0.02 % to 35 % dry weight (dw) for willow and 0.4–29 % for poplar. Within plants, short chain PFAS (i.e., C4–7 perfluoroalkyl carboxylates (PFCA) and C4 perfluoroalkyl sulfonates (PFSA)) primarily accumulated in aboveground biomass, whereas longer chained homologues (C8–14 PFCA, C6–8 PFSA) primarily accumulated in the roots. For hormone and microbial amendments, there were no statistically significant trends for both willow and poplar (p > 0.05). Interestingly, the microbial community composition did not shift based on PFAS exposure but did shift based on plant-species. The PFAS mass balance for willow and poplar after 90 days approached 100 % (p > 0.05) for all PFAS except PFBA, PFPeA, PFOS, and FOSA. These results suggest that while willow and poplar have the potential to extract short chain PFAS from soil, phytoremediation may be more effective at stabilizing PFAS within a given area (i.e., providing hydraulic control) than extracting. }, issn = {2352-1864} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_garcarudolphalejandro_2025, title = {Characterization, outcomes and time to event predictors of urinary tract infections acquired during post-acute stroke inpatient rehabilitation : A comprehensive cohort study}, author = {García-Rudolph, Alejandro and Albu, Sergiu and Wright, Mark Andrew and Laya, Maria Del Mar and Teixido, Claudia and Opisso, Eloy and Cedersund, Gunnar and Bernabeu, Montserrat}, year = {2025}, journal = {Archives of Physical Medicine and Rehabilitation}, volume = {106}, number = {5}, pages = {729--737}, doi = {10.1016/j.apmr.2024.10.007}, url = {1910416}, language = {eng}, publisher = {Elsevier}, keywords = {urinary tract infection; inpatient; stroke; survival analysis}, abstract = {OBJECTIVES: To i) compare baseline clinical and demographic characteristics of post-acute stroke inpatients who were diagnosed with first-time urinary tract infection (UTI) vs inpatients who were not ii) compare rehabilitation outcomes between both groups and iii) examine associations between time to UTI event and risk factors. DESIGN: Retrospective observational cohort study SETTING: Institution for inpatient neurological rehabilitation.PARTICIPANTS: Inpatients (n=1683) admitted within 3 months post-stroke to a rehabilitation facility between 2005 and 2023.INTERVENTIONS: Not applicable.MAIN OUTCOME MEASURES: Functional Independence Measure (FIM), Functional Ambulation Categories (FAC) at admission. Cox proportional hazards models analyzed the association between UTI event timing and risk factors.RESULTS: Of the (n=1683) included patients, 196 (11.6%) experienced a UTI. In 32.1% of cases, the UTI occurred during the first week after admission to rehabilitation and 47.9% of UTIs occurred during the first two weeks. Median (IQR) time to UTI was 16 (5-37) days since admission. Most common germs were Escherichia coli (40.5%), Klebsiella pneumoniae (23.7%) and Pseudomonas aeruginosa (6.4%). Patients who acquired a UTI had older age, higher stroke severity, higher proportion of dysphagia, hypertension, neglect, bilateral affectation, atrial fibrillation, hemiplegia, lower levels of functional independence and lower FAC. We identified no differences in sex, type of stroke (ischemic or hemorrhagic), time to admission, aphasia, diabetes, dyslipidemia, chronic obstructive pulmonary disease, dominant side affected and educational level between both groups. Patients with UTI presented significantly poorer rehabilitation outcomes including lower discharge FIM and FAC, larger LOS, lower FIM efficiency and decreased FIM effectiveness. Multivariable Cox proportional hazards identified hypertension HR=1.60(1.13-2.27), admission FIM HR=0.98(0.97-0.99), admission BMI HR=0.96(0.93-0.99) and admitted with catheter HR= 1.80(1.22-2.64) as significant predictors of time to first UTI event (Concordance-index = 0.754).CONCLUSIONS: UTIs identification, characterization, and predictive factors can support post-acute stroke mitigation strategies to minimize UTI-related complications and optimize rehabilitation outcomes.}, issn = {0003-9993} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_asakawadaichi_2025, title = {Characterizing Seasonal Patterns, Gas-Particle Partitioning, and Potential Sources of Airborne Per- and Polyfluoroalkyl Substances in Japan}, author = {Asakawa, Daichi and Lin, Huiju and Ruan, Yuefei and Taniyasu, Sachi and Yeung, Leo W. Y. and Tojo, Toshiki and Ichihara, Makiko and Yamazaki, Eriko and Hanari, Nobuyasu and Lam, Paul K. S. and Yamashita, Nobuyoshi}, year = {2025}, journal = {Environmental Science and Technology}, volume = {59}, number = {10}, pages = {5145--5154}, doi = {10.1021/acs.est.4c14109}, url = {1942774}, language = {eng}, publisher = {American Chemical Society (ACS)}, keywords = {pfas; aqueous film-forming foams; atmosphere; fluoropolymer manufacturers; positive matrix factorization; spatiotemporal variations}, abstract = {The global ubiquity of perfluoroalkyl and polyfluoroalkyl substances (PFAS) highlights the important role of atmospheric transport. This study monitored 47 PFAS, including perfluoroalkyl acids (PFAAs), emerging PFAS, and precursors of PFAAs (pre-PFAAs), in seasonal ambient air in Japan between 2022 and 2023, quantifying 38 of them in collected samples. The profiles were dominated by 6:2 fluorotelomer alcohol, perfluorobutanesulfonic acid, and perfluorobutanoic acid, with median levels of 245, 117, and 78.0 pg m-3, respectively. Pre-PFAS and perfluoroalkyl carboxylic acids (PFCAs) exhibited relatively higher concentrations in the warm seasons, whereas perfluoroalkyl sulfonic acids (PFSAs) were more abundant in the cold seasons. Particle-bound fractions of PFCAs with carbon number (Cn) ≤ 13 and PFSAs with Cn ≤ 8 were found at lower levels than in previous reports. Additionally, an odd-even pattern in the gas-particle distribution ratio was observed for PFCAs, with relatively higher values for odd-numbered compounds than for their even-numbered counterparts. Using positive matrix factorization analysis, aqueous film-forming foam-related activities, waste stream emissions, and fluoropolymer manufacturing were proposed as potential major sources in the studied areas, with their relative contribution quantified. These findings enhance our understanding of the atmospheric behavior of PFAS and facilitate the development of tailored PFAS mitigation strategies.}, issn = {0013-936X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_demydyukganna_2025_2, title = {Charting the Future of Hospitality with Experience-Based Costing and Revenue Management : How Experience Accounting enables marketing and finance interface}, author = {Demydyuk, Ganna and Carlbäck, Mats}, year = {2025}, journal = {The Hospitality Financial Management Review}, number = {Summer}, pages = {13--20}, url = {1987113}, language = {eng}, publisher = {International Association of Hospitality Financial Management Educators (iAHFME)} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bergmanke_2025, title = {Chemical risk analysis competence in the Nordics is at stake}, author = {Bergman, Åke and Jörundsdóttir, Hrönn and Knudsen, Lisbeth E. and Viluksela, Matti and Alexander, Jan and Krøkje, Åse and Peltonen, Kimmo and Rysä, Jaana and Schnipper, Anette and Sporrong, Per and Ericson Jogsten, Ingrid and Halldórsson, Halldór P. and Hanberg, Annika and Sørig Hougaard, Karin and Sandström, Gunilla and Øvrevik, Johan and Dirven, Hubert}, year = {2025}, journal = {Environmental Science and Pollution Research}, volume = {32}, pages = {11299--11307}, doi = {10.1007/s11356-025-36318-2}, url = {1949577}, language = {eng}, publisher = {Springer}, keywords = {chemicals; competence needs; education; risk assessment; risk communication; training}, abstract = {Toxicology-related experts are on a daily basis working with the safety assessment of chemicals for human health and the environment, providing knowledge applied for management and regulation of chemicals. The field of toxicology is undergoing continuous transition away from traditional safety evaluation studies in experimental animals to application of new approach methodologies (NAMs), the use of omics-related technologies, and concepts like next-generation risk assessment. This requires expertise in the new technologies but does not dismiss the need of knowledge for interpretation of in vivo studies and full understanding of chemical exposure data. A survey was initiated in 2022 in the Nordic countries to assess current and future needs for competences in risk analysis. In total, 40 replies were received from Denmark, Finland, Norway and Sweden, while an expert assessment was performed in Iceland. The responses primarily (87.5%) came from national authorities, research institutes, industry/business, and consultants, less from the hospital system, NGOs, and others. The survey shows obvious difficulties in finding competent and trained personnel in all areas in risk analysis. Since the individual Nordic countries lack critical mass, a Nordic initiative for training and education is recommended to counteract loss of competences within chemical risk analysis in the future.}, issn = {0944-1344} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_elinrost_2025, title = {Chemsex and sexual risk behavior among MSM on PrEP in Stockholm, Sweden}, author = {Elin, Rost and Victor, Westergren and Yauheni, Luksha and Ekström, Anna Mia and Lindberg, Daniel}, year = {2025}, journal = {Drug and alcohol dependence reports}, volume = {16}, doi = {10.1016/j.dadr.2025.100367}, url = {1994593}, language = {eng}, publisher = {Elsevier}, keywords = {chemsex; msm; prep; sti; sexual risk behavior; sexualized drug use; sweden}, abstract = {BACKGROUND: Chemsex, typically defined as the use of specific psychoactive substances to enhance sexual experiences, has been linked to increased sexual health risks among men who have sex with men (MSM). This study examines frequency of chemsex use and associations between chemsex, risk-taking, and sexual practices among MSM on pre-exposure prophylaxis against HIV (PrEP) attending Sweden's largest sexual health clinic.METHODS: A survey among MSM on PrEP (n = 290) mapped demographics, sexualized drug use, sexual practices, and alcohol use at Venhälsan, (South General Hospital), Stockholm, Sweden.RESULTS: 18 % engaged in chemsex at least once in the past year and 49 % of respondents using chemsex reported high-risk alcohol use or alcohol dependence and 13 % classified as dependent. Most individuals on PrEP practiced unprotected sex, 42 % used condoms as passive/bottom, only 31 % as active/top. Chemsex tripled the odds of not using a condom at least 50 % of the time: adjusted for age, education, AUDIT, and being born in Sweden. Participants using chemsex were 3 times more likely, to have more than 14 temporary partners (past year) and were twice as likely to engage in group sex (82 %) compared to those not using chemsex (40 %).CONCLUSIONS: Chemsex was associated with a threefold increased risk of condomless sex and showed a significant link to alcohol dependency. While PrEP offers effective protection against HIV infection, it does not prevent sexually transmitted infections. Health professionals and social workers should identify MSM who engage in chemsex and tailor interventions to address their specific needs.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alnerknutssongabriella_2025_1, title = {Child Welfare Workers' Assessments of Suspected Violence in the Context of Family Law Disputes}, author = {Alner Knutsson, Gabriella and Källström, Åsa}, year = {2025}, journal = {Child & Family Social Work}, doi = {10.1111/cfs.70038}, url = {1991254}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {child maltreatment; child protection; child welfare; child welfare assessments; child welfare investigations; family law}, abstract = {Information about violence in the family can be challenging for child welfare (CW) workers to assess when parents are simultaneously involved in a family law dispute. The aim of this study is to analyse how assessments of suspected violence in the family are described in CW investigations in Sweden when the child's parents are involved in a family law dispute. Text analysis of 32 CW investigations from six municipalities in Sweden was conducted using a version of a multiple case study. Both physical, sexual and psychological violence against the child, including experiencing violence against a parent or a sibling, were included. Our analysis revealed that the CW workers made individual violence assessments. They assessed either that the child had experienced violence, that the presence of violence could not be definitively established, or that the child had not experienced violence. However, even if the main reason to investigate was violence, the CW workers also discussed aspects of the family law dispute, which impacted the final determination and assessment of risks and the child's primary needs. The violence thus sometimes became less important than the parental conflict. It is important for CW workers to be aware of this and to treat violence as no less important than the parental conflict.}, issn = {1356-7500} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_plonerjulia_2025, title = {Childhood peer stressors and adult chronic pain - A life course perspective}, author = {Ploner, Julia and Golovchanova, Nadezhda and Boersma, Katja}, year = {2025}, url = {2018568}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_evansbrittanyerlissa_2025, title = {Childhood self-regulation and life outcomes in a 50-year follow-up study}, author = {Evans, Brittany Erlissa and Berglund, Joakim and Sarnecki, Jerzy and Beckley, Amber L.}, year = {2025}, journal = {International Journal of Behavioral Development}, doi = {10.1177/01650254251358185}, url = {1988819}, language = {eng}, publisher = {Sage Publications}, keywords = {self-regulation; self-control; longitudinal study; registry data; education; criminal conviction; mortality}, abstract = {Self-regulation is integral to human well-being. Previous research established associations between self-regulation and life outcomes, although mostly based on cross-sectional or longitudinal research with relatively short follow-up periods. We aimed to investigate associations between self-regulation during childhood and low education, psychiatric diagnosis, conviction for non-violent and violent crime, and premature mortality up to 50 years later. The sample consisted of boys born between 1943 and 1951 in Stockholm, Sweden, who were initially interviewed as part of the Clientele Study and followed up until they were 58-66 years of age as part of the Stockholm Life Course Project (N = 251). Our measure of self-regulation was indicated by five dimensions extracted from multiple sources and informants when study members were children. Information on life outcomes were extracted from Swedish national registry data available through 2009. Results from logistic regression and survival analyses showed that lower self-regulation during childhood was associated with a higher risk of conviction for non-violent and violent crime, receiving a psychiatric diagnosis and premature mortality up until late adulthood. Self-regulation was not associated with low education. Analyses were adjusted for intelligence and parental socioeconomic status. While based on a relatively small sample and measurement of self-regulation using data from the 1960s, our study supports the notion that self-regulation during childhood is central for well-being across the lifespan.}, issn = {0165-0254} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_andrndaniela_2025_2, title = {Childhood to Retirement : Health and Life Satisfaction Trajectories from a 60-Year Swedish Cohort Study}, author = {Andrén, Daniela and Pettersson, Nicklas}, year = {2025}, url = {2003694}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tangwanjie_2025, title = {Childhood trauma and recent stressors in predicting subclinical psychotic symptoms among Chinese university students in southwest China : a machine learning analysis within a gender-specific framework}, author = {Tang, Wanjie and Deng, Zijian and Sun, Zeyuan and Zhao, Qijun and Garcia-Argibay, Miguel and Anoop, Kadan and Hu, Tao and Xue, Shuang and Bozhilova, Natali and Conti, Aldo and Lukito, Steve and Wu, Siqi and Wang, Gang and Jin, Chunhan and Qiu, Changjian and Liu, Qiaolan and Pan, Jay and Cortese, Samuele and Rubia, Katya}, year = {2025}, journal = {BMJ Mental Health}, volume = {28}, number = {1}, doi = {10.1136/bmjment-2025-301761}, url = {1986729}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {machine learning; child & adolescent psychiatry; data interpretation; statistical; cross-sectional studies}, abstract = {Background: Subclinical psychotic symptoms (SPS) are common among college students and can lead to future mental health issues. However, it is still not clear which specific childhood trauma, stressors and health factors lead to SPSs, partly due to confounding factors and multicollinearity.Objective: To use machine learning to find the main predictors of SPS among university students, with special attention to gender differences.Methods: A total of 21 208 university students were surveyed regarding SPS and a wide range of stress-related factors, including academic pressure, interpersonal difficulties and abuse. Nine machine learning models were used to predict SPS. We examined the relationship between SPS and individual stressors using χ 2 tests, multicollinearity analysis and Pearson heatmaps. Feature engineering, t-distributed stochastic neighborhood embedding (t-SNE) and Shapley Additive Explanation values helped identify the most important predictors. We also assessed calibration with calibration curves and Brier scores, and evaluated clinical usefulness with decision curve analysis (DCA) to provide a thorough assessment of the models. In addition, we validated this model using independent external data.Findings: The Extreme Gradient Boosting (XGBoost) model had the best prediction results, with an Area Under the Curve (AUC) of 0.89, and validated with external data. It also showed good calibration, and DCA indicated clear clinical benefit. Interpersonal difficulties, academic pressure and emotional abuse emerged as the strongest predictors of SPS. Gender-stratified analyses revealed that academic pressure and emotional abuse affected males more, while health issues like chest pain and menstrual pain were stronger predictors for females.Conclusions: Machine learning models effectively identified key stressors associated with SPS in university students. These findings highlight the importance of gender-sensitive approaches for the early detection and prevention of psychotic symptoms.Clinical implications: SPSs in college students can be predicted by interpersonal difficulties, academic stress and childhood emotional abuse. This information can help mental health professionals develop better ways to prevent and address SPSs.}, file = {https://oru.diva-portal.org/smash/get/diva2:1986729/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stresirijakobsson_2025, title = {Children and adolescents' views on coping with stress and aversive feelings - a thematic analysis}, author = {Störe, Siri Jakobsson and Hassler, Sven and Persson, Louise and Beckman, Linda}, year = {2025}, journal = {BMC Public Health}, volume = {25}, number = {1}, doi = {10.1186/s12889-025-23878-8}, url = {1989924}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {adolescent; child; coping; group interview; mental health; resilience}, abstract = {BACKGROUND: The study objective was to explore children and adolescents' views on coping with stress and aversive feelings.METHODS: Swedish children and adolescents from Värmland county, aged 10-14 (N = 44, girls = 26), participated in group interviews on health and coping. In total, eight group interviews were conducted at four different schools.RESULTS: Data was analyzed with reflexive thematic analysis and resulted in three themes: Accepting and expressing feelings, Doing things that make you feel good, and Searching for help.CONCLUSIONS: Encouraging healthy emotional expression, support-seeking, and challenging societal norms can, according to the analysis of children and adolescents' testimonies, foster resilience. Family, peers, student health services, professionals, teachers, and animals contribute to their coping resources, with trust and relatability playing significant roles. The implications of the study can inform and improve future child health interventions and educational programs for nurturing effective coping skills from an early age.} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_arnelllinda_2025_1, title = {Children in Domestic Violence Shelters : International Perspectives}, author = {Arnell, Linda and Thunberg, Sara and Källström, Åsa}, year = {2025}, doi = {10.1007/978-3-031-95477-1}, url = {2003074}, language = {eng}, publisher = {Palgrave Macmillan}, keywords = {violence against children; human rights; child protection; policing violence; refuges}, abstract = {This edited collection provides a detailed picture of children’s lives when living at domestic violence shelters (also termed refuges) which provide a safe space for victims. It draws on original empirical research from countries including the UK, USA, Sweden, Norway, Denmark, Israel and Australia to examine how domestic violence shelters are managed and understood in various social systems. The key themes of the book are school and everyday life, agency and transitions, and support. Using a range of methods including ethnography, interviews, mental health surveys, this book draws on the voices of children, mothers, and workers and explores a range of issues affecting particularly marginalised groups (e.g. infants and teenagers). It includes recommendations for practice and speaks to those in law, social work, nursing and criminology.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_perssonjosefin_2025, title = {Children's exposure risk toward brominated flame retardants and organophosphate esters during preschool attendance and potential contamination sources}, author = {Persson, Josefin and Hagberg, Jessika and Carlberg, Michael and Wang, Thanh}, year = {2025}, journal = {International journal of hygiene and environmental health}, volume = {267}, doi = {10.1016/j.ijheh.2025.114598}, url = {1967286}, language = {eng}, publisher = {Elsevier}, keywords = {bfr; dust; exposure risk; indoor contamination source; ope; preschool}, abstract = {Brominated flame retardants (BFRs) and organophosphate esters (OPEs) are added to various products to gain specific properties such as reduced flammability and increased flexibility, which has resulted in constant, but usually slow, emission of these compounds to indoor environments. Many BFRs and OPEs are persistent, bioaccumulative and toxic, and have often been detected in indoor dust. This has raised concerns because indoor dust has been identified as one of the major non-dietary exposure pathways for children. In this study, 26 BFRs and OPEs were measured in indoor dust samples collected from 26 preschools in Sweden to identify potential indoor contamination sources and estimate the exposure risk of the detected levels. Among the targeted OPEs, tris(2-butoxyethyl) phosphate (TBOEP) was detected in all the preschools, with a mean concentration of 610 mu g/ g. Among the BFRs, decabromodiphenyl ether (BDE-209) was the predominant compound, with a mean concentration of 130 ng/g, even though it is globally regulated. Triphenyl phosphate (TPHP) was significant higher in preschools built before 2014. Also, 2-ethylhexyl diphenyl phosphate (EHDP) and BDE-209 were significant higher in preschools with sound boards on the walls and without wallpaper, respectively. Furthermore, in three of the participating preschools, an increase in total OPEs was observed between the years 2015 and 2023, possibly due to constant release of the targeted compounds and introduction of new and recycled products. Although the detected indoor dust levels showed a low exposure risk, levels of TBOEP were found to significantly contribute to the chemical burden of children attending the preschools.}, issn = {1438-4639} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gonalvesdesousaricardo_2025, title = {Children’s gender constructions in Brazilian Early Childhood Education and Care}, author = {Gonçalves de Sousa, Ricardo and Sales dos Santos, Sandro Vinicius}, year = {2025}, journal = {Journal of Early Childhood Education Research}, volume = {14}, number = {3}, pages = {113--137}, url = {2022602}, language = {eng}, publisher = {Association for Finnish Early Childhood Education}, keywords = {brazil; children's gender constructions; female teacher; male teacher}, abstract = {The present study examines how gender is constructed by four-year-old children in a Brazilian Early Childhood Education and Care (ECEC) setting. The Brazilian context is marked by the omission of discussions about gender in the National Curriculum for ECEC and the rise of conservative groups in the society. The study seeks to show how children’s relationships with adults, in interplay with ECEC spaces, affect how they construct gender. Gender, as a theoretical concept, informed the interpretation and discussion of our findings. A mosaic approach guided the data collection, which consisted of observations and interviews with children, their teachers, and other adults closed to the children’s context both inside and outside the setting. Data were analysed based on thematic analysis with an inductive approach. The findings reveal how the organisation of pedagogical work and the different roles taken by teachers in the class may influence children’s gender constructions. Children’s relationships with their teachers and other adults also show how stereotypical gender assumptions are both reproduced and challenged during play and other situations in the ECEC setting. We argue that educational policies and continuous training for teachers can support them in helping children expand their diverse ways of constructing gender.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_runngreneva_2025, title = {Children’s, parents’ and school nurses’ perspectives on HPV vaccination}, author = {Runngren, Eva}, year = {2025}, url = {1927315}, language = {eng}, publisher = {Örebro University}, keywords = {boys; children; human papillomavirus; parents; school nurses; trust; vaccination}, abstract = {The overall aim of this thesis was to explore and describe children’s, parents’, and school nurses’ perspectives, attitudes, and knowledge of the HPV vaccination. Focus group interviews were performed with 17 school nurses to explore their experiences of offering the HPV vaccination to girls aged 10–12 years (Study I). Twenty parents (Study II) and 13 boys (Study IV) were interviewed face-to-face, the parents about their reasoning regarding the HPV vaccination and the boys about information and communication relating to HPV vaccination. A web-based questionnaire was answered by 206 children and 276 parents about their attitudes and knowledge about the HPV vaccination (Study III). The findings showed different perspectives on HPV vaccination from the children’s, parents’, and school nurses’ viewpoints. The school nurses played a significant role in the process of offering and administering the HPV vaccination (Studies I–IV). They provided information about HPV, and strove to avoid influencing the parents’ decision of whether to vaccinate their child (Study I). Teachers were also described as a source of information (Studies III–IV). Parents expressed trust in the Swedish vaccination program, but showed a lack of knowledge about HPV (Study II). Like the parents, the children showed a lack of knowledge, and were only partially involved in the decision-making process regarding HPV vaccination (III–IV). Overall, the vaccination process is complex, and the school nurse and the teacher play important roles. Children and parents need increased knowledge to make informed decisions regarding HPV vaccination.}, file = {https://oru.diva-portal.org/smash/get/diva2:1927315/FULLTEXT01.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_kllstrmsa_2025, title = {Children’s Perspectives on the Phases of Staying at a Domestic Violence Shelter}, author = {Källström, Åsa and Thunberg, Sara and Arnell, Linda}, year = {2025}, pages = {193--213}, doi = {10.1007/978-3-031-95477-1_10}, url = {2003076}, language = {eng}, publisher = {Palgrave Macmillan}, abstract = {This chapter highlights the challenges that mothers and children face in the different phases of leaving their home to escape violence, staying at a shelter, and then leaving it to start a new life. Based on interviews with mothers and children, it discusses the different perspectives and preconditions that mothers and children have for coping with a stay at a DV shelter in Sweden.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_thunbergulrica_2025, title = {Choice of outcome measure methods affects reported results in stapes surgery : Data from the Swedish quality register for otosclerosis surgery}, author = {Thunberg, Ulrica and Elfstrand, Erika and Lundman, Lars}, year = {2025}, journal = {European Archives of Oto-Rhino-Laryngology}, volume = {282}, number = {12}, pages = {6169--6175}, doi = {10.1007/s00405-025-09567-7}, url = {1990459}, language = {eng}, publisher = {Springer}, keywords = {audiometry; otosclerosis; outcome measure}, abstract = {PURPOSE: To investigate differences in stapes surgery outcome when using different calculation methods.METHODS: Audiometric data were retrieved from the Swedish Quality Register for Otosclerosis Surgery for 3159 surgeries conducted during 2013-2024 with complete pre- and postoperative pure tone audiometry measurements of 0.5, 1, 2, 3, and 4 kHz. Outcomes were calculated in two ways: using 3 kHz versus 4 kHz in four-frequency averaging of air conduction, bone conduction, air-bone gap, and gain.RESULTS: Postoperative air-bone gap improved from 10.0 dB to 7.6 dB when using 3 kHz instead of 4 kHz, and the proportion of successful cases (defined as a postoperative air-bone gap ≤ 10 dB) increased from 62.9% to 79.0%. When 3 kHz was replaced by averaging 2 and 4 kHz, a significantly larger four-frequency air-bone gap was seen in comparison to using the measured 3 kHz.CONCLUSION: This study showed a significant impact on postoperative four-frequency air-bone gap depending on whether the frequency 3 kHz or 4 kHz was included in averaging. The effect appears to be larger than previously described. Bone conduction measurements at 4 kHz produced an anomalous and too low measured hearing level, resulting in a disproportionate impact of the 4 kHz frequency on postoperative four-frequency air-bone gap. Comparison of study results that use different calculation methods should therefore be done with caution. We advocate using the methods recommended by the Committee on Hearing and Equilibrium of the American Academy of Otolaryngology-Head and Neck Surgery for uniformity in presentation of results.}, issn = {0937-4477} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_magyarsumegizsofiadina_2025, title = {Chronic impairment of neurovascular coupling and cognitive decline in young survivors of severe traumatic brain injury}, author = {Magyar-Sumegi, Zsofia Dina and Csendes, Mark and Lendvai-Emmert, Dominika and Sebestyen, Gabriella and Tamas, Viktoria and Bandi, Szabolcs and Czigler, Andras and Yabluchanskiy, Andriy and Tarantini, Stefano and Ungvari, Zoltan and Czeiter, Endre and Amrein, Krisztina and Orsi, Gergely and Perlaki, Gabor and Büki, Andras and Toth, Peter}, year = {2025}, journal = {Journal of Vascular Research}, volume = {62}, number = {Suppl. 1}, pages = {53--53}, url = {1973242}, language = {eng}, publisher = {S. Karger}, abstract = {Background: Severe traumatic brain injury (TBI) leads t ochronic cognitive decline, imposing a significant societal burden. The regulation of cerebral blood flow (CBF) is critical for cognitive function, and acute disruptions in CBF regulation predict poor TBI outcomes. However, the long-term effects of TBI on CBF regulation and their association with cognitive function remain poorly understood.Objective: This study aimed to investigate whether severe TBI results in chronic CBF dysregulation and whether this contributes to long-term cognitive deficits. Additionally, we examined the role of TBI-induced insulin-like growth factor 1 (IGF-1) deficiency in cerebrovascular dysfunction.Methods: We assessed cognitive function, basal CBF (via phase contrast MRI), CBF autoregulation (via transcranial Doppler), and neurovascular coupling (NVC) in 33 TBI survivors (mean age: 37.6 years, ~10 years post-injury) and 21 age-matched healthy controls. Serum IGF-1 levels were also measured.Results: TBI survivors exhibited significant impairments in memory and executive function compared to controls. While basal CBF and autoregulation remained intact, NVC responses were chronically impaired and correlated with cognitive deficits. However, IGF-1 levels did not differ between groups and were not associated with NVC impairment or cognitive function.Conclusion: Our findings indicate that severe TBI results in chronic impairment of neurovascular coupling, which likely contributes to long-term cognitive deficits. These results highlight the need for further research to identify underlying neurovascular mechanisms and develop interventions to restore NVC and cognitive function in TBI survivors.}, issn = {1018-1172} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_magyarsumegizsofiadina_2025_1, title = {Chronic impairment of neurovascular coupling and cognitive decline in young survivors of severe traumatic brain injury}, author = {Magyar-Sumegi, Zsofia Dina and Csendes, Mark and Lendvai-Emmert, Dominika and Sebestyen, Gabriella and Tamas, Viktoria and Bandi, Szabolcs and Czigler, Andras and Yabluchanskiy, Andriy and Tarantini, Stefano and Ungvari, Zoltan and Czeiter, Endre and Amrein, Krisztina and Orsi, Gergely and Perlaki, Gabor and Büki, Andras and Toth, Peter}, year = {2025}, journal = {GeroScience}, volume = {47}, number = {6}, pages = {6927--6939}, doi = {10.1007/s11357-025-01683-w}, url = {1958438}, language = {eng}, publisher = {Springer Cham}, keywords = {autoregulation; brain injury; cbf; cognitive impairment; igf-1; neurovascular hyperemia}, abstract = {Severe traumatic brain injury (TBI) leads to chronic cognitive decline, imposing a significant societal burden. The regulation of cerebral blood flow (CBF) is critical for cognitive function, and acute disruptions in CBF regulation predict poor TBI outcomes. However, the long-term effects of TBI on CBF regulation and their association with cognitive function remain poorly understood. This study aimed to investigate whether severe TBI results in chronic CBF dysregulation and whether this contributes to long-term cognitive deficits. Additionally, we examined the role of TBI-induced insulin-like growth factor 1 (IGF-1) deficiency in cerebrovascular dysfunction. We assessed cognitive function, basal CBF (via phase contrast MRI), CBF autoregulation (via transcranial Doppler), and neurovascular coupling (NVC) in 33 TBI survivors (mean age 37.6 years, ~ 10 years post-injury) and 21 age-matched healthy controls. Serum IGF-1 levels were also measured. TBI survivors exhibited significant impairments in memory and executive function compared to controls. While basal CBF and autoregulation remained intact, NVC responses were chronically impaired and correlated with cognitive deficits. However, IGF-1 levels did not differ between groups and were not associated with NVC impairment or cognitive function. Our findings indicate that severe TBI results in chronic impairment of neurovascular coupling, which likely contributes to long-term cognitive deficits. These results highlight the need for further research to identify underlying neurovascular mechanisms and develop interventions to restore NVC and cognitive function in TBI survivors.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sandbergjacob_2025, title = {Chronobiology in breathlessness across 24 h in people with persistent breathlessness}, author = {Sandberg, Jacob and Sundh, Josefin and Anderberg, Peter and Johnson, Miriam J. and Currow, David C. and Ekström, Magnus}, year = {2025}, journal = {ERJ Open Research}, volume = {11}, number = {1}, doi = {10.1183/23120541.00417-2024}, url = {1932333}, language = {eng}, publisher = {European Respiratory Society}, abstract = {Breathlessness has relatively low variability in daily life, with a gradual decline throughout the day after a morning peak. People who were inactive, and those with more intense breathlessness limiting their exertion had higher levels of breathlessness.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bejerotsusanne_2025, title = {Circular reasoning concerning Red flags for predicting rituximab response in OCD}, author = {Bejerot, Susanne and Hietala, Albert Max and Söderbergh, Annika and Humble, Mats B.}, year = {2025}, journal = {Molecular Psychiatry}, volume = {30}, number = {4}, pages = {1710--1711}, doi = {10.1038/s41380-024-02885-y}, url = {1926151}, language = {eng}, publisher = {Springer Nature}, issn = {1359-4184} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sharmatania_2025, title = {Circulating protein biomarkers and their association with vulnerable plaque characteristics : a PROSPECT II substudy}, author = {Sharma, Tania and Maehara, Akiko and Maeng, Michael and Kjøller-Hansen, Lars and Engstrøm, Thomas and Ben-Yehuda, Ori and Matsumura, Mitsuaki and Fröbert, Ole and Persson, Jonas and Wiseth, Rune and Larsen, Alf Inge and Koul, Sasha and Rylance, Rebecca and Mintz, Gary S. and Ali, Ziad A. and James, Stefan K. and Stone, Gregg W. and Erlinge, David}, year = {2025}, journal = {International Journal of Cardiology: Cardiovascular Risk and Prevention (IJCCRP)}, volume = {26}, doi = {10.1016/j.ijcrp.2025.200440}, url = {1966305}, language = {eng}, publisher = {Elsevier}, keywords = {vulnerable plaque; myocardial infarction; plaque burden; lipid rich plaque; atherosclerosis}, abstract = {Background: In the PROSPECT-II study, near infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) was used to characterize atherosclerotic plaques in the coronary arteries. NIRS-derived lipid core burden index (LCBI) and IVUS-derived plaque burden (PB) were able to identify plaques strongly associated with adverse cardiovascular events.Aim: Our aim was to identify biomarkers associated with LCBI or PB in the coronary arteries.Methods: 898 patients with recent myocardial infarction underwent percutaneous coronary intervention. Blood samples to analyze plasma levels of 179 proteins associated with cardiovascular disease were procured and a combined NIRS-IVUS catheter was used to analyze the coronary arteries. Adjusted linear regression models were calculated between the biomarkers and the outcomes of interest, adjusted for multiplicity testing. Kaplan-Meier survival curves of biomarkers divided by median were assessed with the log-rank test. Adjusted Cox proportional models were calculated for major adverse cardiovascular events.Results: A total of 24 proteins were associated with PB and 28 proteins with LCBI. Eight of these biomarkers were associated with both increased pan-coronary LCBI and PB; IL-18R1, CSF-1, VEGFA, EN-RAGE, cathepsin D, PCSK9, transferrin receptor protein 1 and OPN. After adjusting for multiplicity, angiopoietin like 3 (ANGPTL3) retained its association with LCBI, and IL-18R1 and CSF-1 retained their association with PB.Conclusion: We were able to identify distinct biomarker patterns associated with PB and LCBI. IL-18R1 and CSF-1 had a strong relationship with PB. ANGPTL3 was associated with lipid rich plaques but not with PB, supporting its role in lipid accumulation and development of vulnerable plaques.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_oldaeusalmernanna_2025, title = {Circulating Tumour DNA as a Complementary Tool for Treatment Evaluation in HPV-Associated Head and Neck Squamous Cell Carcinoma : An Observational Cohort Study}, author = {Oldaeus Almerén, Anna and Waenerlund, Max and Landström, Fredrik and Von Beckerath, Mathias and Qvick, Alvida and Carlsson, Jessica and Helenius, Gisela}, year = {2025}, journal = {Clinical Otolaryngology}, volume = {50}, number = {5}, pages = {831--839}, doi = {10.1111/coa.14317}, url = {1954921}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {recist; biomarker; cancer of unknown primary; cthpv‐dna; head and neck squamous cell carcinoma; human papilloma virus; oropharyngeal cancer}, abstract = {OBJECTIVES: HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) and head and neck carcinoma of unknown primary (HNCUP) are increasing. Despite good prognosis, recurrence rates range from 10% to 25%. Surveillance with clinical controls and imaging is not always reliable. Circulating tumour human papillomavirus DNA (ctHPV-DNA) has emerged as a potential biomarker for treatment evaluation and detection of recurrence. We aimed to investigate the correlation between ctHPV-DNA in HPV+ OPSCC/HNCUP and radiologic tumour burden. Additionally, we sought to assess whether ctHPV-DNA could serve as a tool in treatment evaluation.DESIGN: A prospective observational cohort study.SETTING: This multicenter study involved three otolaryngology units located in central Sweden. We utilised HPV genotype-specific assays for droplet digital PCR (ddPCR) to detect ctHPV-DNA in plasma at diagnosis and follow-up. ctHPV-DNA levels were correlated to radiological tumour burden and radiological response using the Kendall Rank correlation coefficient and the Kruskal-Wallis test.PARTICIPANTS: Patients with HPV+ OPSCC/HNCUP undergoing definitive (chemo)radiotherapy and enrolled in the CIRCOS study. RESULTS: Out of 54 patients, 51 were eligible for analyses. At baseline, ctHPV-DNA was detectable in 88%. A majority of patients with a favourable radiological evaluation according to RECIST had a corresponding undetectable ctHPV-DNA at follow-up. The levels of ctHPV-DNA at baseline correlated with total tumour volume and nodal volume (rτ = 0.39, p < 0.01, respectively rτ = 0.26, p < 0.01).CONCLUSION: ctHPV-DNA shows correlation with tumour burden. This study strengthens the role of ctHPV-DNA as a promising biomarker for treatment evaluation in HPV-related OPC/HNCUP. With further research on serial plasma sampling, ctHPV-DNA could complement radiological treatment evaluation in HPV+ OPSCC/HNCUP.TRIAL REGISTRATION: NCT05904327 [ClinicalTrials.gov].}, issn = {1749-4478} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_larssonveronica_2025, title = {CLADCOMS - CLADribine tablets long-term Control Of MS - a post-marketing investigator driven study}, author = {Larsson, Veronica and Forsberg, Linda and Nilsson, Petra and Alonso-Magdalena, Lucia and Svenningsson, Anders and Gunnarsson, Martin and Ayad, Ahmad and Mellergård, Johan and Vrethem, Magnus and Burman, Joachim and Lycke, Jan and Piehl, Fredrik and Fink, Katharina}, year = {2025}, journal = {Multiple Sclerosis Journal}, volume = {31}, number = {3}, pages = {733--733}, url = {2037971}, language = {eng}, publisher = {Sage Publications}, abstract = {Introduction: Cladribine is a deoxyadenosine analogue prodrug that induces immune reconstitution by selectively targeting B- and T-lymphocytes. Cladribine tablets (CladT) are administered in two courses, 12 months apart, for persons with MS (PwMS) with relapsing multiple sclerosis (RMS). Post-marketing surveillance is important for evaluation of long-term safety and effectiveness in a real-world setting. CLADCOMS (CLADribine tablets long-term Control Of MS) is a post-marketing investigator driven study.Objectives/Aims: To investigate the proportion of PwMS free from disease activity with a CladT treatment duration of at least 36 months.Methods: CLADCOMS includes patients with RMS from eight academic neurology clinics in Sweden who started CladT treatment after 23rd of March 2018. Data are prospectively registered in the Swedish Neuroregistry using highly structured annual follow-ups. Descriptive data, relapses, MRI activity, and B-cell lymphocytes levels were obtained from the registry. All statistics were performed using Wilcoxon Signed Rank Test.Results: By March 2025, a total of 147 patients had a treatment duration with CladT of 36 months. The majority of PwMS in this cohort were treatment-naïve (33%) prior to CladT initiation, or had been treated with natalizumab (19%), anti-CD20 (16%) or dimethyl fumarate (12%).The proportion of PwMS being relapse-free over 36 months was 78.2 %, compared to 61.8%, in the year prior CladT start (p= 0.013). For previously treatment-naïve PwMS, 68.7% were relapse-free, compared to 31.2% in the year prior to CladT start (p=0.012). The proportion with new T2 lesions on annual imaging significantly decreased from 11% during the first 12 months to 3% (p<0.01) during year 3. More results will be included in the final presentation.Analys of total B-cell lymphocyte counts showed a drop from baseline (0.42x109/L cells ±0.80) to year 1 (0.20 x109/L cells ±0.18),(p<0.005). The proportion of CD19+/CD27+ B-cells dropped from 12% ± 9% at baseline to 3% ± 3% after 12 months (p<0.005) and the proportions of CD19+ B-cells increased from 68.0% ±13.5% at baseline to 83.0% ±8.7 after 12 months (p<0.005).Conclusion: CladT treatment showed clinical stability after 36 months regardless of previous treatment. The unique immune modulation helps to explain the durability of the effect of CladT. However, continued follow-up is needed to assess the effectiveness and safety of treatment with CladT to investigate time to disease re-activation after full treatment.}, issn = {1352-4585} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vergespere_2025, title = {Classification using hyperdimensional computing : a review with comparative analysis}, author = {Verges, Pere and Heddes, Mike and Nunes, Igor and Kleyko, Denis and Givargis, Tony and Nicolau, Alexandru}, year = {2025}, journal = {Artificial Intelligence Review}, volume = {58}, number = {6}, doi = {10.1007/s10462-025-11181-2}, url = {1947911}, language = {eng}, publisher = {Springer}, keywords = {hyperdimensional computing; vector symbolic architectures; distributed representations; classification; machine learning}, abstract = {Hyperdimensional computing (HD), also known as vector symbolic architectures (VSA), is an emerging and promising paradigm for cognitive computing. At its core, HD/VSA is characterized by its distinctive approach to compositionally representing information using high-dimensional randomized vectors. The recent surge in research within this field gains momentum from its computational efficiency stemming from low-resolution representations and ability to excel in few-shot learning scenarios. Nonetheless, the current literature is missing a comprehensive comparative analysis of various methods since each of them uses a different benchmark to evaluate its performance. This gap obstructs the monitoring of the field's state-of-the-art advancements and acts as a significant barrier to its overall progress. To address this gap, this review not only offers a conceptual overview of the latest literature but also introduces a comprehensive comparative study of HD/VSA classification methods. The exploration starts with an overview of the strategies proposed to encode information as high-dimensional vectors. These vectors serve as integral components in the construction of classification models. Furthermore, we evaluate diverse classification methods as proposed in the existing literature. This evaluation encompasses techniques such as retraining and regenerative training to augment the model's performance. To conclude our study, we present a comprehensive empirical study. This study serves as an in-depth analysis, systematically comparing various HD/VSA classification methods using two benchmarks, the first being a set of seven popular datasets used in HD/VSA and the second consisting of 121 datasets being the subset from the UCI Machine Learning repository. To facilitate future research on classification with HD/VSA, we open-sourced the benchmarking and the implementations of the methods we review. Since the considered data are tabular, encodings based on key-value pairs emerge as optimal choices, boasting superior accuracy while maintaining high efficiency. Secondly, iterative adaptive methods demonstrate remarkable efficacy, potentially complemented by a regenerative strategy, depending on the specific problem. Furthermore, we show how HD/VSA is able to generalize while training with a limited number of training instances. Lastly, we demonstrate the robustness of HD/VSA methods by subjecting the model memory to a large number of bit-flips. The results illustrate that the model's performance remains reasonably stable until the occurrence of 40% of bit flips, where the model's performance is drastically degraded. Overall, this study performed a thorough performance evaluation on different methods and, on the one hand, a positive trend was observed in terms of improving classification performance but, on the other hand, these developments could often be surpassed by off-the-shelf methods. This calls for better integration with the broader machine learning literature; the developed benchmarking framework provides practical means for doing so.}, issn = {0269-2821} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rizeqjala_2025, title = {Climate Worry and Hope Have Different Associations with Well-being and Climate-Friendly Behaviors across Young People from Sweden and Qatar}, author = {Rizeq, Jala and Ojala, Maria}, year = {2025}, journal = {Ecopsychology}, volume = {17}, number = {1}, pages = {68--78}, doi = {10.1089/eco.2024.0002}, url = {1888398}, language = {eng}, publisher = {Mary Ann Liebert}, keywords = {climate change; worry; hope; climate-change engagement; well-being}, abstract = {Climate change is a global crisis posing exceptional threats and demands on our younger generations. Our aim was to understand how climate-change worry and hope relate to climate-friendly behaviors, life satisfaction, and negative affect in young people across Qatar and Sweden—countries with different climates and challenges. Data from young people between 16 and 19 years of age from Sweden (n = 277; 61.37% female) and Qatar (n = 134; 49.25% female) were used. Participants completed questionnaires online. Correlational and regression analyses were used to test bivariate and unique associations and moderation effects. Climate worry was positively associated with climate-friendly behaviors in both samples. Climate worry was positively associated with negative affect and negatively associated with life satisfaction in the sample from Qatar, whereas in the Swedish sample it was only positively associated with negative affect. There was a significant interaction between climate hope and worry on climate-friendly behavior (interaction coefficient = 1.44, p = 0.0032) in the sample from Qatar, and on life satisfaction (interaction coefficient = 0.61, p = 0.036) in the sample from Sweden. Climate hope’s positive effects on these outcomes were significant at higher levels of worry. This study shows the importance of considering both the unique effects and the interplay between hope and worry across regions to understand the impacts of the climate crisis on young people.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_rasmussenbengt_2025, title = {Clinical and genetic studies of high-risk myelodyplastic syndromes and acute myeloid leukemia with chromosome 5q deletion}, author = {Rasmussen, Bengt}, year = {2025}, url = {1943404}, language = {eng}, publisher = {Örebro University}, keywords = {myelodysplastic syndromes; acute myeloid leukemia; chromosome 5q de-letion; complex karyotype; tp53 mutation; clinical trial; azacitidine; lenalidomide; bone marrow trephine biopsy; ihc p53}, abstract = {Patients with high-risk myelodysplastic syndromes (MDS) with a chromosome 5q deletion (del(5q)) have a poor prognosis and are often associated with a complex karyotype and TP53 mutations, factors worsening the prognosis. The hypomethylating agent azacitidine (AZA) is the first-line treatment. Lenalido-mide (LEN) is an effective therapy for lower-risk MDS with del(5q).The aim of this thesis were clinical and genetic studies in patients with high-risk MDS and acute myeloid leukemia (AML) with 20-30% marrow blasts with a karyotype including del(5q). In a prospective, multicenter, open-label, ran-domized phase II study, we studied if AZA + LEN was superior to AZA alone in high-risk MDS and AML with 20-30% marrow blasts with del(5q). Seventy-two patients were included between 2012 and 2017. The overall response rate (ORR) in the treated cohort was 39% for AZA and 44% for AZA + LEN (P=0.63). The addition of LEN to AZA did not improve outcome. In paper II we studied the influence of cytogenetics on treatment response in the study and if specific cytogenetic findings could predict outcome. Patients with del(5q) and complex karyotype or an unbalanced translocation of 5q had a shorter median overall survival (OS) (P=0.004). The aim in paper III was to op-timize diagnostic procedures and follow-up assessment with cytomorphology, bone marrow trephine biopsy and immunohistochemistry (IHC) in patients with higher-risk MDS and AML with 20-30% blasts with a karyotype including del(5q). In 18 patients (25%) a higher bone marrow blast percentage was de-tected by IHC compared to cytomorphology, shifting the diagnosis to either a higher-risk MDS subgroup or AML and is useful for correct subclassification in del(5q) high-risk myeloid disease and for response assessment.In conclusion, the findings in this thesis show that high-risk MDS with del(5q) is a myeloid disorder with a dismal prognosis. There seems to be a window of molecular response to AZA after 3 months of treatment. Future studies should focus on the therapeutic window as a possibility for allogeneic stem cell trans-plantation.}, file = {https://oru.diva-portal.org/smash/get/diva2:1943404/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hlnerik_2025, title = {Clinical course and predictors of outcome following surgical treatment of benign peripheral nerve sheath tumors, a single center retrospective study}, author = {Öhlén, Erik and Gabriel El-Hajj, Victor and Fletcher-Sandersjöö, Alexander and Edström, Erik and Elmi-Terander, Adrian}, year = {2025}, journal = {International Journal of Neuroscience}, volume = {135}, number = {9}, pages = {1034--1040}, doi = {10.1080/00207454.2024.2342977}, url = {1851823}, language = {eng}, publisher = {Taylor & Francis}, keywords = {neurofibroma; outcome; peripheral nerve sheath tumor; risk factors; schwannoma}, abstract = {INTRODUCTION: Peripheral nerve sheath tumors are the most common tumor of the peripheral nerves. In general, surgery has a favorable outcome and is the treatment of choice. However, postoperative neurologic deficits are not uncommon, and predictors of outcome are poorly defined.OBJECTIVE: To evaluate clinical outcomes after surgical treatment of benign peripheral nerve sheath tumors and identify outcome predictors that may affect preoperative decision making and improve surgical outcomes.METHOD: In this single center retrospective study, all patients surgically treated for a benign peripheral nerve sheath tumor between 2005 and 2020 were eligible for inclusion. Medical records and imaging data were reviewed. Studied outcomes were changes in neurological symptoms, pain, and tumor recurrence. Logistic regression was performed to identify possible outcome predictors.RESULTS: In total, 81 patients undergoing 85 separate surgeries for benign peripheral nerve sheath tumors were included. The most common preoperative symptoms were local pain (90%) followed by a noticeable mass (78%), radiating pain (72%), sensory deficit (18%) and motor deficit (16%). A postoperative improvement of symptoms was seen in 94% of those with pain, 48% of those with sensory deficits and 78% of those with motor deficits. However, 35% and 9% developed new postoperative sensory and motor deficits, respectively. Multivariable analysis showed complete tumor removal as a predictor of reduced pain (p = 0.033), and younger age and larger tumors were risk factors for persistent or increased sensory deficits (p = 0.002 and p = 0.005, respectively). There were no significant predictors of motor deficits. Neurocutaneous syndromes were associated with increased odds of tumor recurrence on univariable analysis (p = 0.008).CONCLUSION: Surgery of benign peripheral nerve sheath tumors is a safe procedure with a favorable outcome in most cases. Younger age and larger tumors were risk factors for persistent or increased sensory deficits, while complete tumor removal was associated with reduced pain. Patients with neurocutaneous syndromes had a higher rate of tumor recurrence. To further evaluate outcome predictors, we recommend future studies to focus on longer follow-up periods to assess the natural course of postoperative neurological deficits.}, issn = {0020-7454} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_forsberglinda_2025, title = {Clinical Effectiveness and Safety of Cladribine Tablets for PwMS Treated at least 36 Months in the Swedish post-market surveillance study "Immunomodulation and Multiple Sclerosis Epidemiology 10" (IMSE 10)}, author = {Forsberg, Linda and Larsson, Veronica and Hillert, Jan and Nilsson, Petra and Dahle, Charlotte and Svenningsson, Anders and Lycke, Jan and Burman, Joachim and Martin, Claes and Sundström, Peter and Gunnarsson, Martin and Piehl, Fredrik and Olsson, Tomas}, year = {2025}, journal = {Multiple Sclerosis Journal}, volume = {31}, number = {Suppl. 3}, pages = {396--396}, url = {2037945}, language = {eng}, publisher = {Sage Publications}, abstract = {Introduction: Cladribine is a deoxyadenosine analogue prodrug targeting proliferating B- and T-lymphocytes. Cladribine tablets (CladT) are administered in two courses, 12 months apart, for persons with MS (PwMS) with relapsing MS (RMS). Some PwMS may receive one or more further doses at the discretion of their neurologist.CladT is included in the Swedish post-market surveillance study “Immunomodulation and Multiple Sclerosis Epidemiology 10” (IMSE 10).Objectives/Aims: To assess the safety and effectiveness of CladT with focus on PwMS treated with CladT with at least 3 years of follow up.Methods: Data on Extended Disability Status Scale (EDSS), MS Severity Scale (MSSS), Symbol Digit Modalities Test (SDMT), MS Impact Scale (MSIS-29), European Quality of Life -5 Dimensions Test (EQ-5D), Visual Analog Scale (VAS) scores, relapses, lesions and Adverse Events (AEs) were collected from the nationwide Swedish Neuro Registry (NeuroReg). Effectiveness measures and changes in relapse rates were assessed using Wilcoxon Signed Rank Test.Results: A total of 459 CladT exposed (PwMS) have been included in IMSE 10 since the launch of CladT in April 2018 of which 90% remained with CladT while 47 patients (10%) discontinued treatment at any time after initiation. The most common reason for discontinuation was lack of effect (75%). All AEs reported to the Swedish Medical Products Agency will be shown.A total of 194 (42%) had CladT exposure for ⩾36 months of which 23% were treatment naïve prior to CladT initiation. 19% switched from natalizumab, 10% from dimethyl fumarate and 10% from anti-CD20 to CladT treatment. In this cohort 93% did not switch to another treatment during the following 36 months since treatment initiation with CladT.The 36-months cohort demonstrated clinical stability with a numerical trend for improvement in mean MSSS, SDMT, MSIS-29 Psychological/Physical scores compared with baseline. All other outcomes remained stable. The mean annual relapse rate (ARR) decreased significantly (p<0.05) during all treatment years compared to the ARR in the year prior to treatment start (0.32±0.60 to 0.06±0.26 year1, 0.04±0.22 year2, 0.01±0.07 year 3). The number of PwMS with new T2 lesions decreased from 8% year 1 of CladT treatment to 2% year 2 and 3% year 3.Conclusion: Most PwMS exposed for ⩾36 months to CladT display clinical stability and significant improvements in ARR and T2 lesions. Longer observation times will be needed to assess the effectiveness and safety of CladT beyond 36-month exposure.}, issn = {1352-4585} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_forsberglinda_2025_1, title = {Clinical Effectiveness and Safety of ofatumumab for PwMS Treated at least 12 Months in the Swedish post-market surveillance study "Immunomodulation and Multiple Sclerosis Epidemiology 12" (IMSE 12)}, author = {Forsberg, Linda and Larsson, Veronica and Hillert, Jan and Nilsson, Petra and Dahle, Charlotte and Svenningsson, Anders and Lycke, Jan and Burman, Joachim and Martin, Claes and Sundström, Peter and Gunnarsson, Martin and Piehl, Fredrik and Olsson, Tomas}, year = {2025}, journal = {Multiple Sclerosis Journal}, volume = {31}, number = {Suppl. 3}, pages = {1237--1238}, url = {2039738}, language = {eng}, publisher = {Sage Publications}, abstract = {Introduction: Ofatumumab is a human CD20 monoclonal antibody targeting B-cells and a small population of CD20+ T-cells. The treatment is administered once a month (after initial dosing) with subcutaneous injections for persons with MS (PwMS) with relapsing MS (RMS). Ofatumumab is included in the Swedish post-market surveillance study “Immunomodulation and Multiple Sclerosis Epidemiology 12” (IMSE 12).Objectives/Aims: To assess effectiveness and safety of ofatumumab with focus on 12 months treatment outcomes.Methods: Data on Extended Disability Status Scale (EDSS), MS Severity Scale (MSSS), Symbol Digit Modalities Test (SDMT), MS Impact Scale (MSIS-29), relapses and Adverse Events (AEs) were collected from the nationwide Swedish Neuro Registry (NeuroReg). Effectiveness measures and relapse rates were assessed using Wilcoxon Signed Rank Test. All reported AEs were collected from the Swedish Medical Products Agency (MPA).Results: 188 ofatumumab treated PwMS have been included in IMSE 12 since March 2021. 38% of PwMS had switched from rituximab (age 38.9 ± 10.4, duration (months) since diagnosis (DSD) 107.2 ± 74.5), 25% from natalizumab (age 40.6 ± 10.3, DSD 77.6 ± 76.6), 12% had been treatment naïve/no treatment registered prior start with ofatumumab (age 45.2 ± 12.0, DSD 2.6 ± 4.5) and 25% from other treatments (age 42.2 ± 10.6, DSD 129.2 ± 77.3).15 PwMS discontinued treatment due to AEs (n=9; 5 unspecified, 2 headaches and 2 infections), other reasons (n=4) and pregnancy (n=2). 9 AEs were reported to the MPA (7 serious, 2 non-serious) from 4 individuals.107 PwMS have been treated with ofatumumab for ⩾12 months. The ⩾12month cohort demonstrated a non-significant trend for improvement in mean EDSS, MSSS and SDMT score compared with baseline (EDSS; 2.6 ± 2.5 to 2.5 ± 2.6, p=0.478, MSSS; 3.7 ± 3.1 to 3.5 ± 3.0, p=0.394 SDMT; 55.7 ± 11.5 to 56.0 ± 11.1, p=0.491). The mean annual relapse rate (ARR) decreased significantly (p=0.005) during first year of treatment (0.03 ± 0.22) compared to the ARR (0.10 ± 0.30) one-year prior treatment initiation. The number of PwMS with new T2 lesions decreased significantly (p=0.04) from 6 PwMS the first treatment year with new T2 lesions to none the second treatment year.Conclusion: PwMS treated for ⩾12 months display clinical stability. Significant improvements were seen in both ARR and the proportion of patients with new T2 lesions. Longer observation times will be needed to assess the effectiveness and identify potential AEs of ofatumumab.}, issn = {1352-4585} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_larssonveronica_2025_1, title = {Clinical Effectiveness of Cladribine Tablets for Patients Below or Above 50 years of age at treatment start in the Swedish post-market surveillance study "Immunomodulation and Multiple Sclerosis Epidemiology 10" (IMSE 10)}, author = {Larsson, Veronica and Forsberg, Linda and Hillert, Jan and Nilsson, Petra and Dahle, Charlotte and Svenningsson, Anders and Lycke, Jan and Burman, Joachim and Martin, Claes and Sundström, Peter and Gunnarsson, Martin and Piehl, Fredrik and Olsson, Tomas}, year = {2025}, journal = {Multiple Sclerosis Journal}, volume = {31}, number = {Suppl. 3}, pages = {730--730}, url = {2037960}, language = {eng}, publisher = {Sage Publications}, abstract = {Introduction: Cladribine is a deoxyadenosine analogue prodrug targeting proliferating B- and T-lymphocytes. Cladribine tablets (CladT) are administered in two courses, 12 months apart, for Persons with MS (PwMS) diagnosed with remitting multiple sclerosis (RMS). CladT is included in the Swedish post-market surveillance study “Immunomodulation and Multiple Sclerosis Epidemiology substudy 10” (IMSE 10).Objectives/Aims: To assess effectiveness of CladT with focus on age at treatment start.Methods: Two subgroups in the IMSE 10 study was compared, below <50 or above ⩾ 50 years of age at treatment start. Data on Extended Disability Status Scale (EDSS), MRI activity and annual relapse rate were collected from the nationwide Swedish Neuro Registry (NeuroReg). Effectiveness measures and relapse rates were assessed using Wilcoxon Signed Rank Test.Results: By March 2025, a total of 459 CladT exposed PwMS have been included in IMSE 10 since the launch of CladT in April 2018. This cohort was divided into two subgroups, Below <50 (n=372) and Above ⩾50 (n=87) years of age at treatment start.The proportion of PwMS that discontinued their treatments was five times higher in the younger subgroup (13%) compared to the older subgroup (2.3%) and the most common reason was “Lack of effect” (75.5%). The only given reason for the older subgroup was “other reasons” (100%).The younger subgroup had a mean EDSS that was stable at 1.5 during the first and third treatment year. While the older subgroup showed a decrease in mean EDSS from 3.1 at baseline to 2.8. The mean annual relapse rate (ARR) decreased significantly the third year (mean± SE 0.01 ± 0.01, p<0.005, mean± SE 0.00 ± 0.00, p<0.05) compared to the ARR one-year prior CladT start (mean± SE 0.21 ± 0.03, mean± SE 0.17 ± 0.05) for the younger and older subgroups, respectively.During the first year of treatment 9% of PwMS in the younger subgroup and 10% of PwMS in the older subgroup had new T2 lesions. During the second and third treatment year both subgroups had a decrease in MRI activity to 4% (year2, p=0.0005, year3, p=0.0009) in the younger subgroup and 0% (year 2, p=0.03, year3, p=0.07) in the older subgroup.Conclusion: This data shows that PwMS below and above 50 years of age at treatment start exposed to CladT display clinical stability and a tendency for improvement compared with baseline in several of the investigated outcome measures. PwMS above 50 years at CladT start showed a tendency for less MRI activity compared to PwMS below 50 years of age at treatment start.}, issn = {1352-4585} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_larssonveronica_2025_2, title = {Clinical effectiveness of Cladribine Tablets for patients with few vs many treatments prior CladT initiation in the CLADCOMS study -CLADribine tablets long-term Control Of MS - a post-marketing investigator driven study}, author = {Larsson, Veronica and Forsberg, Linda and Nilsson, Petra and Alonso-Magdalena, Lucia and Svenningsson, Anders and Gunnarsson, Martin and Ayad, Ahmad and Mellergård, Johan and Vrethem, Magnus and Burman, Joachim and Lycke, Jan and Piehl, Fredrik and Fink, Katharina}, year = {2025}, journal = {Multiple Sclerosis Journal}, volume = {31}, number = {Suppl. 3}, pages = {1268--1269}, url = {2038126}, language = {eng}, publisher = {Sage Publications}, abstract = {Introduction: Cladribine is a deoxyadenosine analogue prodrug that induces immune reconstitution by selectively targeting B- and T-lymphocytes. Cladribine tablets (CladT) are administered in two courses, 12 months apart, for persons with MS (PwMS) with relapsing multiple sclerosis (RMS). Post-marketing surveillance is important for evaluation of long-term safety and effectiveness in a real-world setting. CLADCOMS (CLADribine tablets long-term Control Of MS) is a post-marketing investigator driven study.Objectives/Aims: To assess effectiveness of CladT at 36 months follow up with the focus on the number of treatments prior to CladT initiation.Methods: CLADCOMS includes patients with RMS from eight academic neurology clinics in Sweden who started CladT treatment after 23rd of March 2018. PwMS being treatment naïve or exposed to one DMT prior to CladT were compared to PwMS exposed to two or more DMTs prior to CladT start. Data are prospectively registered in the Swedish Neuroregistry using highly structured annual follow-ups. Descriptive data, relapses and MRI activity were obtained from the registry. All statistics were performed using Wilcoxon Signed Rank Test.Results: By March 2025, a total of 147 PwMS had a treatment duration with CladT of at least 36 months. In this cohort 74 PwMS had 0-1 DMTs (“low” subgroup) prior to CladT initiation and, 73 PwMS had 2 or more DMTs (“high” subgroup) prior to CladT. In the “low” subgroup, 66% were treatment-naïve and 11% had been exposed to natalizumab. In the “high” subgroup, the mean number of prior treatments was 4 which included anti-CD20 (29%) and natalizumab (29%).The proportion of PwMS being relapse-free in the group with 0-1 DMT prior was 70% over 36 months of treatment compared to 36% the year before CladT initiation (p=0.005). The proportion of PwMS with new T2 lesions significantly (p=0.05) decreased from 11% during the first treatment year to 5% during the third year.In the group with ⩾2 DMTs prior CladT, there was no significant difference in the proportion of PwMS being free of relapses in the year prior to treatment start (81%) and third treatment year (84%). There was a non-significant decrease in MRI lesion activity during the first treatment year (7%) and third treatment year (2%).Conclusion: CladT treatment showed an improvement in clinical effectiveness after 36 months in the subgroup of PwMS with 0-1 prior treatments, where both relapse activity and MRI lesion activity decreased significantly. For the group with ⩾2 DMTs prior CladT the signs of residual inflammatory disease activity remained stable during the entire treatment period.}, issn = {1352-4585} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_forsberglinda_2025_2, title = {Clinical Effectiveness of Cladribine Tablets for PwMS Switching from Natalizumab, antiCD20 treatment or "other"; data from the Swedish post-market surveillance study "Immunomodulation and Multiple Sclerosis Epidemiology 10" (IMSE 10)}, author = {Forsberg, Linda and Larsson, Veronica and Hillert, Jan and Nilsson, Petra and Dahle, Charlotte and Svenningsson, Anders and Lycke, Jan and Burman, Joachim and Martin, Claes and Sundström, Peter and Gunnarsson, Martin and Piehl, Fredrik and Olsson, Tomas}, year = {2025}, journal = {Multiple Sclerosis Journal}, volume = {31}, number = {Suppl. 3}, pages = {1241--1242}, url = {2037938}, language = {eng}, publisher = {Sage Publications}, abstract = {Introduction: Cladribine is a deoxyadenosine analogue prodrug targeting proliferating B- and T-lymphocytes. Cladribine tablets (CladT) are administered in two courses, 12 months apart, for persons with MS (PwMS) with relapsing MS (RMS). AntiCD20 (aCD20) and Natalizumab (NTZ) are the two most used MS drugs in Sweden. The effects of switching from these drugs to CladT needs further investigations to understand the impact on the clinical effectiveness of such a switch.CladT is included in the Swedish post-market surveillance study “Immunomodulation and Multiple Sclerosis Epidemiology 10” (IMSE 10).Objectives/Aims: To assess the effectiveness of CladT with focus on PwMS treated with NTZ or aCD20 prior to CladT.Methods: The cohort was divided into 3 groups based on treatment prior to CladT; NTZ, aCD20 and other. Data on Extended Disability Status Scale (EDSS), relapses and lesions were collected from the Swedish Neuro Registry. Wilcoxon Signed Rank Test and the McNemar’s statistical tests were used.Results: A total of 459 CladT exposed PwMS have been included in IMSE 10. 82 PwMS were treated with NTZ prior to CladT and 87 with aCD20. The remaining 290 PwMS defined as other included 142 treatment naïve, 48 with dimethyl fumarate and 23 with missing data on prior treatment.Mean EDSS values did not change significantly for the three groups over the 3-year follow-up period.The ARR decreased significantly from 1 year prior to TS compared to the first and third year with CladT for all three groups (NTZ: 0.26 to 0.03 (yr1)/0.03(yr2)/0(yr3), aCD20: 0.16 to 0.05(yr1)/0.08(yr3), other: 0.38 to 0.08(yr1)/0.03(yr2)/0.01(yr3)). However, the aCD20 group had a significantly lower ARR the year prior to TS than the other two groups resulting in a non-significant decrease during the second follow-up year. The remaining two groups had significant decreases in ARR all three years.The proportion of PwMS with new T2 lesions during CladT treatment dropped from 12% the first treatment year to 3% the following two years. This decrease was greater for PwMS previously treated with NTZ or other than aCD20. However, none of these differences were significant.Conclusion: CladT was generally effective for the cohort as a whole. When the cohort was divided by previous treatment data showed greater improvements for PwMS previously treated with NTZ or other than aCD20. However, it is important to note that patients switching from aCD20 had a different profile with a higher initial EDSS level, lower ARR and fewer lesions than the remaining two groups.}, issn = {1352-4585} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_axelssonsofia_2025, title = {Clinical Judgement, Treatment Decisions and Frailty Management in Older Cancer Patients : A Qualitative Study Exploring the Experiences of Radiation Therapy Staff}, author = {Axelsson, Sofia and Fessé, Per and Fransson, Per and Schröder, Agneta and Valachis, Antonis and Ohlsson-Nevo, Emma}, year = {2025}, journal = {Journal of Medical Radiation Sciences}, volume = {72}, number = {4}, pages = {504--511}, doi = {10.1002/jmrs.70017}, url = {1990520}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {decision‐making; experiences; frailty; geriatric assessment; radiation therapy staff}, abstract = {INTRODUCTION: Treatment of older cancer patients can be complex due to frailty that comes with age, and the benefits of radiation therapy for frail older patients are unclear. Radiation therapy staff play a crucial role in identifying and monitoring frailty and tailoring treatment. Research on radiation therapy in frail older patients is limited, and frailty assessments are not widely used in routine care. Understanding staff experiences with clinical judgement and frailty assessment is important for effective treatment. This study explored the radiation therapy staff's experiences of clinical judgement, treatment decision-making, and managing frail older cancer patients.METHODS: The study has an inductive design in which 12 specialist oncology nurses and four clinical oncologists working with cancer patients at four radiation therapy units across four counties in Sweden were interviewed. In total, 16 participants were interviewed for the study. Data were collected in semi-structured individual interviews and were analysed using reflexive thematic analysis. RESULTS: Three themes were identified from the interview analysis: Putting the patient first, Care with integrity and humanity and Receiving support in treatment decisions, along with nine sub-themes. None of the participants was using any structured instrument for assessing frailty.CONCLUSIONS: Radiation therapy staff face significant and complex challenges when treating frail older cancer patients, which can lead to feelings of doubt and powerlessness. Awareness and use of structured frailty assessment are limited. Integrating structured frailty assessment could address the complex challenges experienced by staff by improving decision-making, communication, and patient outcomes, contributing to more ethical and person-centred care.}, issn = {2051-3895} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_axelssonsofia_2025_1, title = {Clinical judgment, treatment decisions, and frailty management in older cancer patients : A qualitative study exploring the experiences of radiotherapy staff}, author = {Axelsson, Sofia and Fesse, P. and Fransson, P. and Schröder, Agneta and Valachis, Antonis and Ohlsson-Nevo, Emma}, year = {2025}, journal = {Annals of Oncology}, volume = {36}, number = {Suppl. 2}, pages = {S1541--S1541}, doi = {10.1016/j.annonc.2025.08.1177}, url = {2038381}, language = {eng}, publisher = {Elsevier}, abstract = {Background: Radiotherapy is commonly used in older patients, but it is unclear whether frail patients benefit from the treatment. Radiotherapy staff play a crucial role in the care of older cancer patients, as they have the opportunity to identify and monitor frailty and tailor radiotherapy to the patient's condition. To successfully implement a structured frailty assessment, it is important to understand staff's experiences of clinical judgement, treatment decisions, frailty assessment and treatment of older cancer patients. Therefore, the aim of this study was to explore the radiotherapy staff's experiences of clinical judgement, treatment decision making and management of frail older cancer patients.Methods: The study has an inductive design in which 16 staff from four radiotherapy units in four counties in Sweden were interviewed. Data were analysed using reflexive Thematic Analysis.Results: Three themes, and nine subthemes, were identified from the interview analysis: Putting the patient in first: Participants emphasized the importance of considering older frail patients' overall wellbeing, quality of life, and personal circumstances in treatment decisions. Care with integrity and humanity: Clinical assessment of older cancer patients is complex. Doubt and ethical issues arise in treatment decisions for frail patients or those receiving palliative care. Receiving support in treatment decisions: Decision support instruments like frailty assessments could aid in treatment planning but effective use of frailty assessment requires knowledge and training.Conclusions: Radiotherapy staff face significant and complex challenges when treating frail older cancer patients, which can lead to feelings of doubt and powerlessness. Awareness and use of structured frailty assessment is limited. Integrating structured frailty assessment could address the complex challenges experienced by staff by improving decision making, communication, and patient outcomes, contributing to more ethical and person-centred care.}, issn = {0923-7534} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ellingsenjens_2025, title = {Clinical phenotypes predict exacerbations of COPD : the TIE cohort study}, author = {Ellingsen, Jens and Janson, Christer and Bröms, Kristina and Farkhooy, Amir and Hårdstedt, Maria and Högman, Marieann and Lisspers, Karin and Palm, Andreas and Ställberg, Björn and Malinovschi, Andrei}, year = {2025}, journal = {Respiratory Medicine}, volume = {244}, doi = {10.1016/j.rmed.2025.108182}, url = {1966484}, language = {eng}, publisher = {Elsevier}, abstract = {Background: In 2017, Burgel and colleagues developed an algorithm to identify clinical phenotypes that predict mortality in COPD. Our study aimed to 1) investigate whether the phenotypes can predict acute exacerbations of COPD (AECOPD) and 2) validate their ability to predict mortality.Methods: The Tools Identifying Exacerbations (TIE) cohort study recruited participants with spirometry-verified COPD from primary and secondary care in three Swedish regions. Participants were allocated to phenotypes 1-5 using the previously developed algorithm containing comorbidities (heart failure, coronary artery disease, hypertension, and/or diabetes), dyspnoea, age, forced expiratory volume in 1 s (FEV1), and body mass index (BMI). Data on AECOPDs and deaths during the three-year follow-up were collected from medical records and analysed with Cox proportional hazards regressions. Harrel's C-index was used to assess the models' discriminative ability.Results: Among the 566 participants, 59 % were female, and the mean +/- SD FEV1 was 57 +/- 18 % of predicted. The hazard ratios (HRs) [95 % CI] for time to AECOPD were 3.04 [1.93-4.79], 2.38 [1.54-3.66], and 3.52 [1.73-7.15] in phenotypes 1, 2, and 4 compared with 5 (C-index = 0.61). When AECOPD history was used to predict future AECOPD the C-index was 0.65. The HRs [95 % CI] for mortality were 8.24 [1.93-35.3], 6.26 [1.40-28.0], and 16.7 [3.25-86.3] in phenotypes 1, 3, and 4 compared to 5 (C-index = 0.68). For AECOPD history, the C-index was 0.55.Conclusion: Clinical COPD phenotypes based on comorbidities, dyspnoea, age, FEV1, and BMI predict AECOPDs but do not perform better than AECOPD history. However, they perform better than AECOPD history in predicting mortality.}, issn = {0954-6111} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_frnqvistkenneth_2025, title = {Clinical rating scales for assessing pain in newborn infants}, author = {Färnqvist, Kenneth and Olsson, Emma and Garratt, Andrew and Paraskevas, Themistoklis and Soll, Roger F. and Bruschettini, Matteo and Persad, Emma}, year = {2025}, journal = {Cochrane Database of Systematic Reviews}, volume = {4}, doi = {10.1002/14651858.MR000064.pub2}, url = {1951776}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {infant; premature; intensive care units; neonatal; *pain measurement [methods] [standards]; *pain; procedural [diagnosis]; randomized controlled trials as topic; humans; newborn}, abstract = {BACKGROUND: Six to nine per cent of all newborn infants require admission to a neonatal intensive care unit (NICU) due to either illness or prematurity. During their stay, these infants are often subjected to many painful procedures that can cause negative long-term consequences. To reduce the negative effects of pain exposure and ensure optimal and safe pain treatment, accurate assessment of pain is necessary. To achieve this, clinicians are dependent on the use of reliable, objective, and standardised clinical rating scales of pain, henceforth referred to as 'rating scales'. Numerous rating scales have been published; however, discrepancies in validity limit their overall applicability in clinical practice and research. Such limitations may lead to an over- or underestimation of pain, resulting in unnecessary sedation or inadequately treated pain, potentially jeopardising infant safety through treatment side effects, including withdrawal symptoms or prolonged discomfort. To date, the majority of rating scales have been developed to assess procedural pain, whilst fewer scales for prolonged pain are available. Premature infants further complicate matters, as they often have a reduced ability to display robust pain behaviour due to their immaturity. Research has also shown that the use of rating scales in clinical practice is suboptimal, due to both inadequate and infrequent implementation alongside inappropriate choice of scale for the specific pain, population, or setting under evaluation. Despite numerous studies investigating the burden of pain in newborn infants, little work has been done to summarise the current evidence on the appropriateness of rating scales for specific types of pain or infant conditions. This has likely been limited by the subjectivity of pain assessment and further complication of assessing such a non-verbal and immature patient population. The immense burden of neonatal pain worldwide has also led to the development of numerous rating scales in various languages, further hindering evidence summation.OBJECTIVES: To systematically review the literature to compile and describe the development, content, and measurement properties of clinical rating scales for the assessment of pain in newborn infants.SEARCH METHODS: An Information Specialist systematically searched CENTRAL, PubMed, Embase, and CINAHL. The latest update search is current to July 2023. SELECTION CRITERIA: We included all study designs that involved the development or testing of a rating scale for assessing pain in newborn infants. We included preterm (born before week 37) and term (born at week 37 or beyond) infants undergoing pain assessment for any medical indication. We also included studies that included healthcare professionals.DATA COLLECTION AND ANALYSIS: We evaluated clinical rating scales assessing pain in newborn infants using the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) methodology evaluating content validity, structural validity, internal consistency, reliability, measurement error, hypothesis testing, and cross-cultural validation. We used a modified GRADE approach to assess risk of bias, inconsistency, imprecision, and indirectness.MAIN RESULTS: We included 79 studies involving a total of 7197 infants, 326 nurses, and 12 physicians. Twenty-seven clinical rating scales were used in 26 countries, with 14 studies evaluating preterm infants, 11 on term infants, 46 on both preterm and term infants, four solely on medical staff, and four on preterm and/or term infants plus medical staff. Following the COSMIN checklist, we found all rating scales to be of very low-certainty evidence, raising concerns regarding their validity, reliability, and applicability in this vulnerable population across diverse clinical settings.AUTHORS' CONCLUSIONS: Clinical staff should be vigilant when applying the currently available neonatal rating scales. Further development of rating scale content and testing for structural validity are necessary and should be prioritised. Together, they determine the content and structure of rating scales, underpin further testing, including reliability, and their prioritisation will make the greatest contribution to the evidence base for rating scales to assess neonatal pain. Collaborative efforts between clinicians and methodology experts will prevent methodological pitfalls and contribute to improving the validity and reliability of pain-rating scales in neonatology.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parlatinivaleria_2025, title = {Clinical response to a single-dose methylphenidate challenge is indicative of treatment response at two months in adults with ADHD}, author = {Parlatini, Valeria and Radua, Joaquim and Thomas, Hannah and Garcia-Argibay, Miguel and Bellato, Alessio and Cortese, Samuele and Murphy, Declan}, year = {2025}, journal = {Translational Psychiatry}, volume = {15}, number = {1}, doi = {10.1038/s41398-025-03557-3}, url = {2004263}, language = {eng}, publisher = {Springer Nature}, abstract = {Stimulants such as methylphenidate (MPH) are the first-line pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD). Although stimulants are effective at a group level, individual response varies, which advocates for tailored treatment approaches. Prior studies suggested that neurobiological measures following a single dose of stimulants are indicative of longer-term clinical response. To expand these findings, we tested whether an association between acute and longer-term treatment response can also be identified using measures commonly used in clinic. Sixty adults with ADHD completed clinico-neuropsychological measures, including the Barkley Adult ADHD Rating Scale-IV (BAARS-IV) and the Quantitative behavior (Qb) test, following a single dose of MPH (20 mg) and placebo. These measures were repeated after two-month MPH treatment to ascertain response. We tested associations between single-dose and longer-term response using univariate and multivariable (Lasso) regression approaches. We also ran correlations between predicted and true outcome measures. Univariate regressions showed significant associations between single-dose and two-month improvement in BAARS hyperactivity/impulsivity and Qb scores (all p < 0.001 but Qb activity, p = 0.006). Multivariable models including acute response and baseline clinicodemographic measures yielded significant correlations between predicted and actual values for all BAARS-IV and Qb scores at follow-up, except for BAARS inattention and Qb activity. Most had large/very large effect size (up to r = 0.69). These findings suggest that specific clinico-neuropsychological changes following a single dose of MPH may be indicative of longer-term treatment response, especially when combined with pre-treatment clinico-demographic characteristics. Once validated in larger and more heterogeneous samples, these results may support more informed and individualized treatment approaches for ADHD.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_magnussoncarl_2025, title = {Clinical usefulness of tools used for screening and measuring frailty in the ambulance and emergency department in older people : a scoping review protocol}, author = {Magnusson, Carl and Wahlstedt, Nellie and Östlundh, Linda and Wissendorff Ekdahl, Anne and Hugelius, Karin and Kurland, Lisa}, year = {2025}, journal = {BMJ Open}, volume = {15}, number = {12}, doi = {10.1136/bmjopen-2025-111454}, url = {2024439}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {emergency departments; frail elderly; frailty}, abstract = {INTRODUCTION: As people age, frailty becomes increasingly prevalent and is associated with adverse outcomes, including higher risks of hospitalisation, institutionalisation and mortality. Early identification of frailty in ambulance and emergency department (ED) settings may support clinical decision-making and help predict outcomes for older patients. However, there is currently no consensus on how frailty should be assessed in these settings, and the clinical usefulness of available tools remains uncertain. This protocol outlines the methods for a planned scoping review that aims to identify frailty screening tools used for older adults (age ≥65 years) in the ambulance and ED settings and to evaluate existing evidence on their clinical usefulness.METHODS AND ANALYSIS: This protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for Protocols, and the final review will follow the Joanna Briggs Institute methodology and is reported in accordance with the PRISMA extension for Scoping Reviews guidelines. Studies will be included if they examine the use of frailty screening or assessment tools in individuals aged 65 years or older in ambulance and/or ED settings and report on aspects of clinical usefulness, such as feasibility, predictive validity or influence on clinical decisions. A comprehensive literature search will be conducted in PubMed, Embase, CINAHL, Scopus and Web of Science for studies published in English between January 2014 and December 2025. To refine the search strategy, an initial systematic pre-search was performed in PubMed using Medical Subject Headings terms, followed by a pilot study. A sample pilot screening of 101 references identified in the pre-search was conducted as a support for finalising the search. Ten of the papers in the pre-screening were furthermore used as a support for testing and validating the data extraction variables and quality assessment procedures. In the full scoping review, study selection and data extraction will be independently conducted by two reviewers using the Covidence software (Veritas Health Innovation, Melbourne, Australia), with any discrepancies resolved by a third reviewer. Extracted data will be summarised in tabular format and analysed through narrative synthesis. The methodological quality of included studies will be evaluated using the quality assessment tool of the National Heart, Lung, and Blood Institute for cohort studies.ETHICS AND DISSEMINATION: Ethical approval is not required as no primary data will be collected. Findings will be disseminated through publication in a peer-reviewed journal, conference presentations and summaries shared with relevant clinical and research-related stakeholders.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_adolfssonemma_2025, title = {Clinical validation and experiences of the microfluidics sperm selection device ZyMōt™ for standard IVF}, author = {Adolfsson, Emma and Ingberg, Johanna and Igersten, Emma and Bohlin, Therese}, year = {2025}, journal = {JBRA assisted reproduction}, volume = {29}, number = {2}, pages = {244--250}, doi = {10.5935/1518-0557.20240104}, url = {1925702}, language = {eng}, publisher = {Villimpress}, keywords = {clinical validation; density gradient centrifugation; in vitro fertilization; microfluidics; sperm selection; sperm selection device}, abstract = {OBJECTIVE: Clinical validation of sperm selection device ZyMōt™ for standard IVF.METHODS: The pre-clinical validation of ZyMōt™ included several steps. First, split semen preparation compared density gradient centrifugation (DGC) to ZyMōt™ with primary outcome fraction and absolute number of progressive motile sperm. Second, sibling oocytes were fertilized with sperms prepared with DGC and sperms selected by ZyMōt™, primary endpoint fertilization rate, utility rate, embryo development pace quality. After this, DGC was replaced by ZyMōt™, first without centrifugation steps, and then with a five-minute centrifugation step and subsequent media change prior to gamete co-incubation. Endpoint was assessment of key performance indicators against previous results using DGC for standard IVF.RESULTS: ZyMōt™ resulted in purer sperm selection compared to DGC (fraction progressive motile sperm 97.2±3.1% vs. 83.0±14.1%, p<0.01). Fertilization of sibling oocytes resulted in similar fertilization rates and utility rates, and no differences in embryo development pace or quality. However, after changing sperm selection protocol from DGC to ZyMōt™ for standard IVF for all fresh semen samples with motile sperm, the fertilization rates and utility rates were significantly reduced, and cases of total failure of fertilization increased substantially. Adding five-minute centrifugation and media change after centrifugation to the sperm selection protocol restored fertilization rate, including total failure of fertilization rate, to normal.CONCLUSIONS: To conclude, the ZyMōt™ sperm selection device is suitable for standard IVF only after inclusion of five minutes centrifugation and subsequent media change prior to gamete co-incubation.}, issn = {1517-5693} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_areljungsofie_2025, title = {Co-drawing to Learn in Science}, author = {Areljung, Sofie and Andersson, Johanna and Hermansson, Carina and Skoog, Marianne and Sundberg, Bodil}, year = {2025}, journal = {Research in science education}, volume = {55}, pages = {1189--1204}, doi = {10.1007/s11165-024-10217-x}, url = {1918183}, language = {eng}, publisher = {Springer}, keywords = {science education; collaborative learning; drawing; sociomaterialist approaches}, abstract = {This article is about the pedagogical potentials and challenges of co-drawing in science education. It builds on video data from three primary school classrooms where students worked in pairs to draw some science content on a shared paper. Grounded in a sociomaterialist approach, we analyse how students, drawing tools, paper templates, visual resources, and science concepts collaborate during drawing activities. Our findings reveal that even though two students share a paper they do not necessarily negotiate their understandings of the science content they are asked to draw. For example, one student may shape a verbal and visual narrative about the science content with little input from the other, or negotiations may focus more on drawing techniques and composition than on understanding the science content. However, the article identifies a promising scenario in terms of science learning opportunities, when both students draw within a confined space on the paper. In such cases, it seems that science learning emerge while drawing and that both students are involved in a joint learning process.}, issn = {0157-244X} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_forsbergper_2025, title = {Coercive and mutual relations in the Swedish textile industry : The Case of Rydboholm’s Factories}, author = {Forsberg, Per}, year = {2025}, pages = {106--144}, url = {1973193}, language = {eng}, publisher = {Malmö universitet}, keywords = {time/credit-gap; textile history; rydboholms fabriker; credit institutions; mauss; graeber}, abstract = {In this chapter, by taking the time–credit lag as a starting point, it is possible to analyze how the capitalistic moral economy that spread through the globalization of the cotton industry during the 19th century developed in a unique Swedish context. The argument relies on an illustrative case of a time–credit lag in the production chain that Rydboholm’s factories were a part of, uncovering the specific challenges the company faced when solving this lag, and how different arrangements, such as credit solutions, hierarchical dominance, and coercion, involved different social relations.}, file = {https://oru.diva-portal.org/smash/get/diva2:1973193/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_salomonbenita_2025_1, title = {Cohort profile : the Swedish Inception Cohort in inflammatory bowel disease (SIC-IBD)}, author = {Salomon, Benita and Grännö, Olle and Bergemalm, Daniel and Strid, Hans and Carstens, Adam and Hjortswang, Henrik and Lundström, Maria Ling and Hreinsson, Johann P. and Almer, Sven and Bresso, Franscesca and Eriksson, Carl and Grip, Olof and Blomberg, André and Marsal, Jan and Nickaeen, Niloofar and Bakhtyar, Shoaib and Lindqvist, Carl Mårten and Hultgren Hörnquist, Elisabeth and Magnusson, Maria K. and Keita, Åsa V. and D'Amato, Mauro and Repsilber, Dirk and Öhman, Lena and Söderholm, Johan D. and Carlson, Marie and Hedin, Charlotte R. H. and Kruse, Robert and Halfvarson, Jonas}, year = {2025}, journal = {BMJ Open}, volume = {15}, number = {5}, doi = {10.1136/bmjopen-2025-099218}, url = {1960057}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {inflammatory bowel disease; gastroenterology; prognosis}, abstract = {Purpose: There is a need for diagnostic and prognostic biosignatures to improve long-term outcomes in inflammatory bowel disease (IBD). Here, we describe the establishment of the Swedish Inception Cohort in IBD (SIC-IBD) and demonstrate its potential for the identification of such signatures.Participants: Patients aged >= 18 years with gastrointestinal symptoms who were referred to the gastroenterology unit due to suspected IBD at eight Swedish hospitals between November 2011 and March 2021 were eligible for inclusion.Findings to date: In total, 367 patients with IBD (Crohn's disease, n=142; ulcerative colitis, n=201; IBD-unclassified, n=24) and 168 symptomatic controls were included. In addition, 59 healthy controls without gastrointestinal symptoms were recruited as a second control group. Biospecimens and clinical data were collected at inclusion and in patients with IBD also during follow-up to 10 years. Levels of faecal calprotectin and high-sensitivity C-reactive protein were higher in patients with IBD compared with symptomatic controls and healthy controls. Preliminary results highlight the potential of serum protein signatures and autoantibodies, as well as results from faecal markers, to differentiate between IBD and symptomatic controls in the cohort. During the first year of follow-up, 37% (53/142) of the patients with Crohn's disease, 24% (48/201) with ulcerative colitis and 4% (1/24) with IBD-U experienced an aggressive disease course.Future plans: We have established an inception cohort enabling ongoing initiatives to collect and generate clinical data and multi-omics datasets. The cohort will allow analyses for translation into candidate biosignatures to support clinical decision-making in IBD. Additionally, the data will provide insights into mechanisms of disease pathogenesis.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gustafssonjannik_2025, title = {Cold- and hot-water immersion are not more effective than placebo for the recovery of physical performance and training adaptations in national level soccer players}, author = {Gustafsson, Jannik and Montiel Rojas, Diego and Romare, Mattias G. A. and Johansson, Elin and Folkesson, Mattias and Pernigoni, Marco and Frolova, Anastasija and Brazaitis, Marius and Venckunas, Tomas and Ponsot, Elodie and Chaillou, Thomas and Edholm, Peter}, year = {2025}, journal = {European Journal of Applied Physiology}, volume = {125}, pages = {3179--3194}, doi = {10.1007/s00421-025-05835-w}, url = {1969932}, language = {eng}, publisher = {Springer}, keywords = {athletes; cooling; exercise; fatigue; football; heating}, abstract = {PURPOSE: Cold- and hot-water immersion (CWI and HWI, respectively) are popular post-exercise recovery methods in competitive soccer. The aims of this study were to (1) compare the effect of post-exercise CWI, HWI and placebo on the recovery of physical performance in national level soccer players, and (2) investigate whether repeated use of these recovery modalities has an impact on training adaptations over a 15 week period.METHODS: For Part I, 40 male soccer players (15-19 years) were randomized to either CWI (10 °C, 10 min), HWI (42 °C, 20 min), or placebo (6 min, sham laser), applied after a 90 min simulated soccer match (SSM). Physical performance was assessed using submaximal aerobic, 20 m sprint, countermovement jump (CMJ), and knee extension strength tests [i.e., maximum voluntary isometric contraction (MVIC) and time to exhaustion (TTE) at 60% of MVIC] performed at Pre-SSM and 0, 21 and 45 h Post-SSM. For Part II, 19 participants applied their respective recovery modality (~ twice a week) in their usual training. After 15 weeks, physical performance and body composition were assessed and compared to pre-intervention.RESULTS: All three modalities similarly affected the recovery of physical performance during the 21-45 h Post-SSM period (p < 0.05). Moreover, no significant effects of the recovery modalities on body composition and on development of physical performance were found over the 15 week recovery intervention (p > 0.05).CONCLUSION: Compared to a placebo, CWI and HWI do not improve post-match recovery of physical performance and do not impact long-term training adaptations in highly trained soccer players.}, issn = {1439-6319} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_liyike_2025, title = {Combat sports in virtual reality for rehabilitation and disability adaptation : a mini-review}, author = {Li, Yike and Jiang, Chun and Li, Hansen and Su, Yuqin and Li, Mengyao and Cao, Yang and Zhang, Guodong}, year = {2025}, journal = {Frontiers in Public Health}, volume = {13}, doi = {10.3389/fpubh.2025.1557338}, url = {1946425}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {adaptive physical activities; boxing; combat sports; rehabilitation; virtual reality}, abstract = {This review examines the existing literature regarding the utilization of combat sports in virtual reality (VR) for disease rehabilitation and adaptive physical activity. A total of 18 studies were obtained from the Web of Science and Scopus databases. The results suggest that Boxing, the most studied combat sport in VR systems, has been primarily used to improve motor function and quality of life in patients with neurological conditions such as cerebral palsy, Parkinson's disease, and stroke. Furthermore, VR combat sports have been shown to increase energy expenditure and physical activity intensity in individuals with disabilities, proving effective in maintaining overall physical health. Notably, VR boxing produces higher energy expenditure than other activities (e.g., tennis), with heart rate (HR) and oxygen consumption (VO2) during boxing sessions consistently exceeding those observed in tennis. Overall, research in this field remains limited and further explorations are warranted.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_liaoponsjudit_2025, title = {Combined targeting of PRDX6 and GSTP1 as a potential differentiation strategy for neuroblastoma treatment}, author = {Liaño-Pons, Judit and Garde-Lapido, Elisa and Fahrig, Fenja L. and Jäckering, Merle and Yuan, Ye and Andersson, Stina and Schort, Lea and Esteve, Maria and Mohlin, Sofie and Bedoya Reina, Oscar and Arsenian-Henriksson, Marie}, year = {2025}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, volume = {122}, number = {25}, doi = {10.1073/pnas.2427211122}, url = {1973010}, language = {eng}, publisher = {Proceedings of the National Academy of Sciences (PNAS)}, keywords = {antioxidants; childhood cancer; differentiation-inducing therapy; neuroblastoma; oxidative stress}, abstract = {Neuroblastoma (NB) is a heterogeneous childhood cancer, characterized by the amplification of the MYCN oncogene in 40% of the high-risk cases. Our previous work demonstrated that MYCN drives metabolic reprogramming in NB, including upregulation of antioxidant enzymes. Here, we identify peroxiredoxin 6 (PRDX6) as a promising therapeutic target in NB. Pharmacological inhibition of PRDX6 reduces MYCN levels, induces apoptosis, and promotes neuronal differentiation accompanied by lipid droplet accumulation, essential for the phenotypic reprogramming. Moreover, combined inhibition of PRDX6 and glutathione S-transferase Pi 1 (GSTP1), a key antioxidant enzyme needed for PRDX6 activation, demonstrated synergistic effects both in vitro and in vivo. This strategy results in neuronal maturation as well as activity and initiates downstream pathways distinct from the ones triggered by retinoic acid, the differentiation-inducing agent currently used in clinical practice for NB. Notably, both PRDX6 and GSTP1 are highly expressed in the developing murine adrenal gland, as well as in high-risk, MYCN-amplified NB, correlating with an undifferentiated state and poor prognosis. Together, our results provide insights into the potential of PRDX6 and GSTP1 as therapeutic targets for differentiation induction for children with NB.}, issn = {0027-8424} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_bachrachyoram_2025, title = {Combining Code Generating Large Language Models and Self-Play to Iteratively Refine Strategies in Games}, author = {Bachrach, Yoram and Toledo, Edan and Hambardzumyan, Karen and Magka, Despoina and Josifoski, Martin and Jiang, Minqi and Foerster, Jakob and Raileanu, Roberta and Shavrina, Tatiana and Cancedda, Nicola and Ruderman, Avraham and Millican, Katie and Lupu, Andrei and Hazra, Rishi}, year = {2025}, pages = {10999--11003}, doi = {10.24963/ijcai.2025/1249}, url = {2020923}, language = {eng}, keywords = {agent-based and multi-agent systems; mas; applications game theory and economic paradigms; gtep; other natural language processing; nlp; language models}, abstract = {We propose a self-play approach to generating strategies for playing in multi-player games, where strategies are represented as computer code. We use large language models (LLMs) to generate pieces of code to play in the game, which we refer to as generated bots. We engage the LLM generated bots in competitions, designed to generate increasingly stronger strategies. We follow game theoretic principles in organizing these tournaments, and use a Policy Space Response Oracle (PSRO) approach. We start with an initial set of LLM generated bots, and continue in rounds for adding new bots into the population. Each round adds a bot to the population by asking the LLM to produce code for playing against a bot representing the Nash equilibrium mixture over the current population. Our analysis shows that even a few rounds are sufficient to produces strong bots for playing the game. Our demo shows the process for the game of Checkers. We allow users to select initial bots in the population, run the process, inspect how the bots evolve over time, and play against the generated bots.}, file = {https://oru.diva-portal.org/smash/get/diva2:2020923/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_carlsenmisicmartina_2025, title = {Combining skin-to-skin contact, breastfeeding andparents live singing as neonatal pain management : Results from the SWEpap RCT}, author = {Carlsen Misic, Martina and Ericson, Jenny and Olsson, Emma and Ullsten, Alexandra}, year = {2025}, url = {1973944}, language = {eng}, keywords = {pain; parents; newborn infant; breastfeeding; skin-to-skin; infant directed singing}, abstract = {Background Parents are a valuable but underutilizedresource in neonatal pain management. Involving parentshave shown to be efficient for pain relieving and combiningseveral parent-delivered methods could increase the effect.Aim The aim of this study was to investigate the pain-relieving effects of parent-delivered pain managementcombining skin to skin contact (SSC), breastfeeding, andlive parental lullaby singing compared with SSC alone andwith standard care using oral glucose in healthy newborninfants.Material and method Multicenter randomizedcontrolled trial with three parallel groups during routineblood sampling in postnatal care. Parent-infant dyads(n=225) were recruited from three health care regions inSweden and randomized to one of the three groups; 1 –standard care with oral glucose, 2- SSC 3 – a combinationof SSC, breastfeeding (if applicable) and live parentallullaby singing. Primary outcome was pain expressionassessed with Premature infant pain profile –Revised(PIPP-R), secondary outcomes were skin conductance andparents’ evaluation of pain, stress and meaningfulness.Results Median PIPP-R was 5 (IQR 3–6) for group 1, 7(5–9) for group 2, and 7 (5–10) for group 3 (p < 0.001).There were no significant differences in skin conductance.Parents’ VAS-assessment (Figure 1) of infant pain rangedfrom a median of 9.5 to 17 mm, significantly higher ingroups 2 and 3 (p = 0.017). The parents rated their ownstress as low 4.5 - 6.5 mm and very high formeaningfulness 93 - 96 mm.Conclusion This was the first large RCT to evaluate combined parent-delivered painmanagement including parents’ live singing. Pain scores remained within the mild to moderate range across all groups, with the infants receiving oral glucose having significantly lower pain scores. The results indicated that involving parents leads to low stress and high sense of meaningfulness. Combined parent-delivered pain management is feasible and safe.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_raffeineraaron_2025, title = {Combining Static and Mobile Sensors on a Quadruped Robot for Adaptive and Responsive Gas Sensing with Low-Cost Sensors}, author = {Raffeiner, Aaron and Haarbach, Adrian and Fan, Han and Lilienthal, Achim J. and Pohle, Roland}, year = {2025}, url = {2027417}, language = {eng}, abstract = {Monitoring of gas emissions is critical for ensuring safety, efficiency, and compliance in industrial plants. Approaches based on stationary sensor networks leave areas of the plant unmonitored and lack adaptability to changing conditions. Combining stationary with mobile sensors on quadruped robots offers a robust approach with improved spatial resolution, adaptability and responsiveness. To streamline the integration of such systems, a unified and open software framework is required. We propose to abstract the low-level implementations, e.g., the robot control layers, using the REST API to facilitate the implementation of high-level tasks such as data visualization and AI-based analysis, thus enabling scalable monitoring solutions. An indoor gas release experiment was conducted, which showed the benefits of the quadruped robot-based and the combined sensing approach.}, file = {https://oru.diva-portal.org/smash/get/diva2:2027417/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_humblematsb_2025_1, title = {Commentary on : "IUPHAR review - Novel therapeutic targets for schizophrenia treatment: A translational perspective"}, author = {Humble, Mats B. and Eklund, Daniel and Bejerot, Susanne}, year = {2025}, journal = {Pharmacological Research}, volume = {216}, doi = {10.1016/j.phrs.2025.107757}, url = {1956078}, language = {eng}, publisher = {Academic Press}, keywords = {antibodies; b-lymphocyte depletion; immunomodulatory treatment; rituximab; schizophrenia; therapeutic targets}, issn = {1043-6618} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_ervolaura_2025, title = {Communication in Multicultural Procedures : Cross-National Perspectives}, author = {Ervo, Laura and Kaakinen, Miika}, year = {2025}, pages = {73--117}, url = {1993977}, language = {eng}, publisher = {Örebro University} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nakevavonmentzercecilia_2025, title = {Communicative activity and participation in children with speech sound disorder : a case series using the ICF framework}, author = {Nakeva von Mentzer, Cecilia and Ranjbar, Parivash and Strandberg, Thomas}, year = {2025}, journal = {Logopedics, Phoniatrics, Vocology}, volume = {50}, number = {3}, pages = {157--168}, doi = {10.1080/14015439.2025.2480108}, url = {1948853}, language = {eng}, keywords = {child; icf; communicative activity and participation; speech sound disorder}, abstract = {The everyday lives of young children with speech sound disorder (SSD) are not well described, with few studies taking a holistic view with interaction in focus. The aim of this study was to investigate how SSD affects communicative activity and participation in everyday life of four children in a Swedish context. The study involved 4 triads: 4 children with SSD aged 4 to 7, their parents (n = 4), grandmothers (n = 2) and pedagogues, i.e. preschool teachers (n = 2). The research design was a case series, including speech language tests, questionnaires and structured interviews. The International Classification of Functioning, Disability and Health (ICF) served as an analytical framework. Results showed reduced speech intelligibility in all children. Interrupted thought processes, tantrums and social withdrawal were negative effects of the SSD. Having a friend in the out-of-home environment was a facilitating factor, enabling the children with SSD use their full capacity in social interaction. When knowledge about SSD is shared in all environments, all forces that influence the child positively may be aligned in a collaborative effort and a holistic understanding can be reached. To accomplish this, ICF serves as a valuable conceptual framework.}, issn = {1401-5439} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_walhelmtomas_2025, title = {Comorbid psoriasis in systemic lupus erythematosus : a cohort study from a tertiary referral centre and the National Patient Register in Sweden}, author = {Walhelm, Tomas and Parodis, Ioannis and Enerbäck, Charlotta and Arkema, Elizabeth and Sjöwall, Christopher}, year = {2025}, journal = {Lupus Science and Medicine}, volume = {12}, number = {1}, doi = {10.1136/lupus-2025-001504}, url = {1967983}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {autoantibodies; lupus erythematosus; systemic; treatment}, abstract = {OBJECTIVES: To investigate the prevalence of psoriasis in SLE using a Swedish regional cohort and a nationwide cohort from the National Patient Register (NPR). Furthermore, we compared clinical features between patients with and without comorbid psoriasis.METHODS: In total, 351 patients diagnosed with SLE based on the 1982 American College of Rheumatology and/or the 2012 Systemic Lupus International Collaborating Clinics criteria from Linköping University Hospital were evaluated. We obtained patient-reported and relevant clinical data extracted in 2024. Individuals with coexisting psoriasis were identified via the International Classification of Diseases code L40 and subsequent confirmation through chart review in the regional cohort. In the NPR, 7490 subjects with SLE living in Sweden in 2022 were identified, as well as therapies obtained from the Prescribed Drug Register.RESULTS: We identified 12 subjects with SLE and coexisting psoriasis (3.4%) in the regional cohort and 367 patients (4.9%) in the nationwide cohort. Men were proportionally more common in the group with comorbid psoriasis in both cohorts. Patients with psoriasis reported more pain on a visual analogue scale (median 45.5/100 mm, IQR 23.3-58.3) compared with those without coexisting psoriasis (median 27.0/100 mm, IQR 7.0-50.5, p<0.04). We observed no differences in damage accrual or clinical phenotypes between the two groups. Subjects with psoriasis were more frequently prescribed methotrexate in the nationwide cohort.CONCLUSION: The prevalence of coexisting psoriasis in patients with SLE in Sweden was estimated to be 3.4-4.9%. Individuals with comorbid psoriasis reported more pain and were more likely to be prescribed methotrexate than those without psoriasis.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_farhatluisc_2025, title = {Comparative cardiovascular safety of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults : a systematic review and network meta-analysis}, author = {Farhat, Luis C. and Lannes, Alice and Del Giovane, Cinzia and Parlatini, Valeria and Garcia-Argibay, Miguel and Ostinelli, Edoardo G. and Tomlison, Anneka and Chang, Zheng and Larsson, Henrik and Fava, Cristiano and Montastruc, François and Cipriani, Andrea and Revet, Alexis and Cortese, Samuele}, year = {2025}, journal = {Lancet psychiatry}, volume = {12}, number = {5}, pages = {355--365}, doi = {10.1016/S2215-0366(25)00062-8}, url = {1950351}, language = {eng}, publisher = {Elsevier}, abstract = {Background: Concerns about the cardiovascular safety of medications used for the treatment of attention-deficit hyperactivity disorder (ADHD) remain. We aimed to compare the effects of pharmacological treatments for ADHD on haemodynamic values and electrocardiogram (ECG) parameters in children, adolescents, and adults. Methods: For this systematic review and network meta-analysis, we searched 12 electronic databases, including Cochrane CENTRAL, Embase, PubMed, and the WHO International Clinical Trials Registry Platform, from database inception to Jan 18, 2024, for published and unpublished randomised controlled trials comparing amphetamines, atomoxetine, bupropion, clonidine, guanfacine, lisdexamfetamine, methylphenidate, modafinil, or viloxazine against each other or placebo. Primary outcomes were change in systolic blood pressure (SBP) and diastolic blood pressure (DBP), measured in mm Hg, and pulse, measured in beats per minute, at timepoints closest to 12 weeks, 26 weeks, and 52 weeks. Summary data were extracted and pooled in random-effects network meta-analyses. Certainty of evidence was assessed with the Confidence in Network Meta-Analysis (CINeMA) framework. This study was registered with PROSPERO, CRD42021295352. Before study initiation, we contacted representatives of a UK-based charity of people with lived experience of ADHD—the ADHD Foundation—regarding the relevance of the topic and the appropriateness of the outcomes chosen.Findings: 102 randomised controlled trials with short-term follow-up (median 7 weeks [IQR 5–9]) were included, encompassing 13 315 children and adolescents (aged ≥5 years and <18 years; mean age 11 years [SD 3]; of available data, 9635 [73%] were male and 3646 [27%] were female; of available data, 289 [2%] were Asian, 1719 [15%] were Black, and 8303 [71%] were White) and 9387 adults (≥18 years, mean age 35 years [11]; of available data, 5064 [57%] were male and 3809 [43%] were female; of available data, 488 [6%] were Asian, 457 [6%] were Black, and 6372 [79%] were White). Amphetamines, atomoxetine, lisdexamfetamine, methylphenidate, and viloxazine led to increments in haemodynamic values in children and adolescents, adults, or both. In children and adolescents, mean increase against placebo ranged from 1·07 (95% CI 0·36–1·79; moderate CINeMA confidence) with atomoxetine to 1·81 (1·05–2·57; moderate) with methylphenidate for SBP; from 1·93 (0·74–3·11; high) with amphetamines to 2·42 (1·69–3·15; low) with methylphenidate for DBP; and from 2·79 (1·05–4·53; moderate) with viloxazine to 5·58 (4·67–6·49; high) with atomoxetine for pulse. In adults, mean increase against placebo ranged from 1·66 (95% CI 0·38–2·93; very low) with methylphenidate to 2·3 (0·66–3·94; very low) with amphetamines for SBP; from 1·60 (0·29–2·91; very low) with methylphenidate to 3·07 (0·69–5·45; very low) with lisdexamfetamine for DBP; and from 4·37 (3·16–5·59; very low) with methylphenidate to 5·8 (2·3–9·3; very low) with viloxazine for pulse. Amphetamines, lisdexamfetamine, or methylphenidate were not associated with larger increments in haemodynamic values compared with atomoxetine or viloxazine in either children and adolescents or adults. Guanfacine was associated with decrements in haemodynamic values in children and adolescents (mean decrease against placebo of –2·83 [95% CI –3·8 to –1·85; low CINeMA confidence] in SBP, –2·08 [–3 to –1·17; low] in DBP, and –4·06 [–5·45 –2·68; moderate] in pulse) and adults (mean decrease against placebo of –10·1 [–13·76 to –6·44; very low] in SBP, –7·73 [–11·88 to –3·58; very low] in DBP, and –6·83 [–10·85 to –2·81; very low] in pulse). Only four RCTs informed on effects in the medium term and none on the long term.Interpretation: Practitioners should monitor blood pressure and pulse in patients with ADHD treated with any pharmacological intervention, and not stimulants only. Given the short duration of available randomised controlled trials, new research providing insights on the causal effects of ADHD medications on cardiovascular parameters in the longer term should be funded. Funding National Institute for Health and Care Research.}, issn = {2215-0374} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kumarayushi_2025, title = {Comparative chloroplast genomics of wild-type Panicum miliaceum cv. ATL1 and its M4 mutant line : insights for molecular breeding applications}, author = {Kumar, Ayushi and Rajasekaran, Ravikesavan and Krishnamoorthy, Iyanar and Alagarswamy, Senthil and Chandrakumar, K. and Pulapet, Sowmya and Markkandan, Kesavan and Kanagarajan, Selvaraju and Narayanan, Manikanda Boopathi}, year = {2025}, journal = {BMC Plant Biology}, volume = {25}, number = {1}, doi = {10.1186/s12870-025-06999-5}, url = {1990510}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {panicum miliaceum; chloroplast genome; codon bias; mutagenesis; phylogenomic analysis; poaceae; proso millet; ssr analysis}, abstract = {BACKGROUND: Proso millet (Panicum miliaceum L.), one of the oldest domesticated crop, remains an underexploited resource with significant potential for nutrition and yield. With evolving breeding perspectives, genomic knowledge is increasingly vital for developing new crop varieties. However, the limited genomic information on indigenous proso millet hinders its full utilization. This study addresses this gap by compiling chloroplast genome (cp. genome) data for the native variety ATL1 and its mutant derivative TNPmPEM 001, aiming to facilitate the development of new varieties.RESULTS: Both Panicum miliaceum cv. ATL1 and TNPmPEM 001 chloroplast genomes exhibited the characteristic quadripartite structure. While they shared identical total lengths (139 837 bp), small single-copy (SSC: 12 795 bp), large single-copy (LSC: 84 522 bp), and inverted repeat (IR: 20 560 bp) regions, these metrics diverged from the reference genome, which displayed a total length of 139 826 bp, with distinct SSC (12 574 bp), LSC (81 682 bp), and IR (22 785 bp) regions. While soybean, cotton, sunflower, and pea constituted outgroups, the phylogenetic analysis showed a tight link between ATL1, TNPmPEM 001 and reference cp. genome as well as with little millet. The identification of protein-coding genes regulating photosynthesis components (photosystems I and II, NADH dehydrogenase, cytochrome complexes, rubisco, and ribosomal/tRNA/rRNA genes) in both investigated cp. genomes provides critical insights into the genomic basis of photosynthesis efficiency in underutilized C4 crops like proso millet, a key trait for improving stress-resilient sustainable agriculture. Additionally, 11 unique simple sequence repeat (SSR) markers, exclusively identified in the mutant derivative, offer novel tools for marker-assisted breeding programs targeting agronomic trait enhancement.CONCLUSIONS: These findings address critical gaps in proso millet genomics, particularly the limited molecular resources for Indian landraces. The mutant-derived SSRs and structural variants offer actionable targets for enhancing yield stability under variable photoperiods, a priority for climate-resilient proso millet breeding in marginal agroecosystems.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_larssonjoakim_2025, title = {Comparative study of conventional and Nanodiamondcoated wire drawing dies}, author = {Larsson, Joakim and Karlsson, Patrik and Olsson, Mikael}, year = {2025}, volume = {13}, pages = {338--346}, url = {1993002}, language = {eng}, keywords = {wire drawing; drawing dies; nano dies; coating; diamond coating; nano diamond coating}, abstract = {The wire drawing process enhances the material properties and dimensional accuracy of hotrolledwire by pulling it through dies typically made of cemented carbide or diamond. Despiteethical and health concerns associated with cobalt, a key component of cemented carbide, itremains the most common choice due to its cost-effectiveness and durability. Recently, NanoDies, i.e. cemented carbide dies coated with a nano-crystalline diamond coating, have gainedattention, offering claims of lifespans twenty to hundred times longer than conventional dies.These dies have the potential to reduce cobalt dependence and improve the efficiency andsustainability of wire drawing. However, the price of these tools varies significantly, by up toa factor of twenty, creating uncertainty about performance differences across price segments.This paper presents an in-depth comparison of conventional cemented carbide dies with twodifferent nano dies from different price ranges, focusing on the surface characteristics of thedies and especially the coating characteristics of the nano dies. Additionally, laboratory wiredrawing experiments were conducted to assess the performance of these new tools comparedto conventional dies.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_pleusstefan_2025, title = {Comparator Value Pairing Impacts Reported Continuous Glucose Monitoring System Accuracy}, author = {Pleus, Stefan and Freckmann, Guido and Slingerland, Robbert J. and Diem, Peter and Eriksson Boija, Elisabet and Fokkert, Marion and Hinzmann, Rolf and Jendle, Johan and Klonoff, David C. and Lu, Jingyi and Makris, Konstantinos and Mohan, Viswanathan and Nichols, James H. and Pemberton, John and Selvin, Elizabeth and Thomas, Andreas and Tran, Nam K. and Witthauer, Lilian and Eichenlaub, Manuel}, year = {2025}, journal = {Journal of Diabetes Science and Technology}, volume = {19}, number = {5}, pages = {1423--1426}, doi = {10.1177/19322968251344303}, url = {1960664}, language = {eng}, publisher = {Diabetes Technology Society}, keywords = {cgm performance; accuracy; continuous glucose monitoring; standardization} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alzbedyamnah_2025, title = {Comparison of CIC and HR GFMAS for the measurements of extractable organofluorines (EOF) in different biological tissues of pilot whales}, author = {Al Zbedy, Amnah and Aro, Rudolf and Akhdhar, Abdullah and Müller, Viktoria and Ebel, Rainer and Brownlow, Andrew and Norton, Gareth J. and Yeung, Leo W. Y. and Feldmann, Joerg}, year = {2025}, journal = {Analytica Chimica Acta}, volume = {1351}, doi = {10.1016/j.aca.2025.343855}, url = {1950240}, language = {eng}, publisher = {Elsevier}, abstract = {BACKGROUND: In most water and biological samples, the sum of target or even non-target PFAS makes up only a small fraction of the extractable organofluorine (EOF). The methods used for EOF analysis in the methanol are combustion ion chromatography (CIC) and recently high-resolution graphite furnace molecular absorption spectrometry (HR GFMAS). Water samples show a bias towards higher concentrations measured with HR GFMAS than that of CIC. Whether the bias depends on the type of PFAS or on the sample matrix has not been known. Here we study the PFAS compound and the matrix effect using HR GFMAS and compare these with the CIC results.RESULTS: Calibration of the HR GFMAS with fluoride exhibit significant higher response than using PFOA indicating a compound specific effect. PFOA calibration gave in the average quantitative recoveries for different type of PFAS in methanol, although neutral PFAS (FTOH) show lower recoveries than PFCA using HR GFMAS. Spiked PFOA in brain and liver tissue samples resulted in quantitative recoveries (101 %) using HR GFMAS. 44 liver, kidney, blubber and brain samples from stranded pilot whales were analysed by HR GFMAS and compared to the EOF concentrations analysed by CIC. All EOF results were above the LOD of both methods; 27 and 916 ng/g (CIC) and between 77 and 3130 ng/g (HR GFMAS). In general HR GFMAS gave significantly higher results for all tissues than CIC (p > 0.05). Correlations between the EOF of all tissues showed a tissue dependant behaviour.SIGNIFICANCE: Since PFOA recovery was in brain and liver quantitative, the results indicate that PFAS type influence the performance using HR GFMAS. Overall, we found the concentrations in the different tissues to be comparable with the two methods within one order of magnitude. This highlights the fact that more work is needed to identify the matrix effects and fluorine species dependant responses of both methods.}, issn = {0003-2670} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_westmananja_2025, title = {Competences needed for disaster responders}, author = {Westman, Anja}, year = {2025}, url = {1961675}, language = {eng}, publisher = {Örebro University}, keywords = {disaster medicine; competence; non-technical skills; disaster response; disaster responders}, abstract = {Disasters strike worldwide and cause large-scale suffering. However, there is only limited knowledge on how to best prepare disaster responders, and no universal consensus on the core competences that disaster responders need or should be required to have. The aim of this thesis was to understand the competences used and needed by disaster responders.This thesis is based on four studies: two using a qualitative design with content analysis (Study I) and reflexive thematic analysis (Study IV), one scoping review (Study II) and one cross-sectional study (Study III). The results showed that although disaster responders are a diverse group, the competences they require are based on a combination of technical skills, non-technical skills, previous experience and personal traits. Leadership skills, teamwork skills and communication seem to be the most important skills for disaster responders’ ability to act during a disaster response mission. Another important aspect of disaster response is mental preparedness. Although disaster specific technical skills should form the foundation of disaster training programs, there is a need for a greater focus on non-technical skills. When technical and non-technical skills are combined with desirable personal traits, mental preparedness, and previous experience as well as training tailored for the disaster responders and adequate for the task, this seems to provide the best context for creating competence among disaster responders.}, file = {https://oru.diva-portal.org/smash/get/diva2:1961675/FULLTEXT04.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sjlanderarvid_2025, title = {Competing explanations in Bayesian networks - The small town murder problem revisited}, author = {Sjölander, Arvid and Lindkvist, Gustav}, year = {2025}, journal = {Science & justice}, volume = {65}, number = {6}, doi = {10.1016/j.scijus.2025.101337}, url = {2007823}, language = {eng}, publisher = {Elsevier}, keywords = {bayesian networks; causality; competing explanations}, abstract = {The use of probability theory and statistical reasoning in legal contexts is controversial, with several wellknown thought experiments highlighting perceived paradoxes. One example is the small town murder problem, recently discussed by de Zoete et al., who argued that the perceived paradoxes arise from a failure to properly distinguish between hypotheses and evidence, and can be resolved using Bayesian networks. While we agree with their general conclusions, we contend that their analysis of the small town murder problem overlooks a central issue and underutilizes the full potential of Bayesian modeling. In this note, we propose an alternative analysis of the problem, drawing on well-known results on conditioning on a common effect of two factors.}, issn = {1355-0306} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zerdesioannis_2025, title = {Comprehensive Genome Profiling for Treatment Decisions in Patients with Metastatic Tumors : Real-World Evidence Meta-Analysis and Registry Data Implementation}, author = {Zerdes, Ioannis and Filis, Panagiotis and Fountoukidis, Georgios and El-Naggar, Ali Inan and Kalofonou, Foteini and D'Alessio, Antonio and Pouptsis, Athanasios and Foukakis, Theodoros and Pentheroudakis, George and Ahlgren, Johan and Smith, Daniel and Valachis, Antonis}, year = {2025}, journal = {Journal of the National Cancer Institute}, volume = {117}, number = {6}, pages = {1117--1124}, doi = {10.1093/jnci/djaf015}, url = {1931456}, language = {eng}, publisher = {Oxford University Press}, abstract = {BACKGROUND: Although precision oncology has rapidly been developed in recent years, its real-world impact and challenges in healthcare implementation remain underexplored. Through a meta-analysis of real-world evidence (RWE), we aimed at investigating the applicability and clinical impact of comprehensive cancer genome profiling (CGP) in cancer patients with metastatic solid tumors.METHODS: We systematically searched Medline, Embase, and Web of Science for RWE studies on CGP and matched therapies in metastatic solid tumors (publication period: 2012-2023). Pooled proportions of actionable genomic alterations, patients treated with matched targeted therapies, treatment, and survival outcomes were calculated. Data from Swedish cancer registries were used as a case-study for nationwide CGP implementation.RESULTS: Out of the 7218 identified studies, 144 were included in our analysis. 59.8% of CGP-tested patients had actionable genomic alterations, with 15.6% (95% Confidence Interval (CI) 13.4-18.2%) of them having received targeted therapy. Objective response was seen in 23.9% (95% CI 20.8-27.3%). Overall, CGP-guided treatment was correlated with prolonged progression-free survival (pooled Hazard Ratio (HR) = 0.63; 95% CI, 0.56-0.70; 18 studies) and overall survival (pooled HR = 0.60; 95% CI, 0.51-0.70; 21 studies) when compared to conventional treatment. Meta-regression time projections analyses showed that these rates will steadily increase by 2030.CONCLUSIONS: Pooled analyses of RWE studies indicate that approximately one-fourth of the patients receiving CGP-matched treatment have an objective response. By utilizing meta-regression projections, our nationwide cancer registry case-study offers insights into the potential of precision oncology for patients with metastatic cancer and to inform future healthcare strategies.}, issn = {0027-8874} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jendebergjohan_2025, title = {Computed tomography urography in macroscopic hematuria : a retrospective study with implications for standard care pathway}, author = {Jendeberg, Johan and Björkman, Alma and Dahlman, Pär and Eklöf, Hampus and Eriksson, Elisabeth and Hellström, Mikael and Holst, Susanna and Karalli, Amar and Leonhardt, Henrik and Magnusson, Anders and Meurling, Edward and Papatziamos Hjelle, Christian and Sjögren, Adam and Tila, Rodica and Wallström, Jonas and Öman, Jenny and Nyman, Ulf}, year = {2025}, journal = {Acta Radiologica}, doi = {10.1177/02841851251387444}, url = {2023852}, language = {eng}, publisher = {Sage Publications}, keywords = {computed tomography; hematuria; lead time; radiation dose; standardized care pathway; urography; urothelial cancer (urinary tract tumors)}, abstract = {Background: Standardized care pathway (SCP) for macrohematuria (patients aged ≥50 years) in Sweden includes four-phase computed tomography urography (CTU) before cystoscopy, but targeted SCP lead time for CTU (6 days)/treatment is fulfilled in <25% of patients.PurposeTo retrospectively analyze the incidence of CTU-diagnosed upper urinary tract (UUT), kidney and bladder tumors, calculi, radiation dose, and its implications for SCP.Material and Methods: A total of 4491 consecutive CTU reports on macrohematuria indication were reviewed, mainly during 2022 (86.6%) from nine radiology units: four regions, three university hospitals, and two private units. Tumor findings were verified via biopsy/cytology reports, CTU characteristics, and follow-up. Effective patient radiation doses were calculated.Results: In patients aged ≥50 years (n = 3915) the incidence of UUT/kidney/bladder tumors was 0.9%/1.0%/6.9%, respectively, and of calyceal, pelvic, ureteral, and bladder calculi was 13%, 2.0%, 2.7%, and 2.2%, respectively. Median effective dose was 12.9 mSv (range=10-22 mSv) in the six radiology units using four-phase CTU in 87%-100% of the examinations and 9-12 mSv in the three units using four-phase in 3%-53%.Conclusion: The limited incidence of UUT and kidney tumors diagnosed at CTU for macrohematuria necessitates a multidisciplinary discussion on how to improve SCP lead times for the vast majority with urothelial tumors, i.e. bladder tumors. Alternative diagnostic pathways such as cystoscopy and clinical risk evaluation before CTU should be contemplated. Additionally, there is a need to optimize radiation dose by reducing the number of CTU phases on one hand and without losing significant diagnostic accuracy on the other hand.}, issn = {0284-1851} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kymnchristopherj_2025, title = {Computing With Residue Numbers in High-Dimensional Representation}, author = {Kymn, Christopher J. and Kleyko, Denis and Frady, E. Paxon and Bybee, Connor and Kanerva, Pentti and Sommer, Friedrich T. and Olshausen, Bruno A.}, year = {2025}, journal = {Neural Computation}, volume = {37}, number = {1}, pages = {1--37}, doi = {10.1162/neco_a_01723}, url = {1914280}, language = {eng}, publisher = {MIT Press}, abstract = {We introduce residue hyperdimensional computing, a computing framework that unifies residue number systems with an algebra defined over random, high-dimensional vectors. We show how residue numbers can be represented as high-dimensional vectors in a manner that allows algebraic operations to be performed with component-wise, parallelizable operations on the vector elements. The resulting framework, when combined with an efficient method for factorizing high-dimensional vectors, can represent and operate on numerical values over a large dynamic range using resources that scale only logarithmically with the range, a vast improvement over previous methods. It also exhibits impressive robustness to noise. We demonstrate the potential for this framework to solve computationally difficult problems in visual perception and combinatorial optimization, showing improvement over baseline methods. More broadly, the framework provides a possible account for the computational operations of grid cells in the brain, and it suggests new machine learning architectures for representing and manipulating numerical data.}, issn = {0899-7667} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_krzyzanowskamichal_2025, title = {Conceptual flipsiding and reversal of liberal-democratic notions : discursive-political strategies in/and the normalisation of illiberal public imagination}, author = {Krzyzanowska, Michal and Krzyzanowska, Natalia and Rydgren, Jens}, year = {2025}, journal = {Social Semiotics}, doi = {10.1080/10350330.2025.2601608}, url = {2029018}, language = {eng}, publisher = {Routledge}, keywords = {conceptual flipsiding; illiberalism; liberal-democratic concepts; social and political concepts; critical discourse studies; discourse-conceptual analysis}, abstract = {The process of strategically redefining key liberal-democratic and other widely accepted social and political concepts by the far-right and other illiberal actors has recently become a widespread, cross-national phenomenon. Seeing it as integral to both the ongoing mainstreaming of the far right and the ever more pervasive, social-wide normalisation of illiberalism, we define this process as "conceptual flipsiding" and elaborate on it here from a set of interdisciplinary perspectives and in various contexts. We view "conceptual flipsiding" as the key component of illiberal "discursive shifts" in the public sphere that facilitate durable infusion of illiberalism into public discourse by changing the ways of speaking and thinking about key social and political ideas and issues. Exploring both theoretically and empirically the multiple dynamics, trajectories and intricacies of "conceptual flipsiding," we approach it as a strategic process wherein various public actors contribute to the ongoing illiberal discursive colonisation of liberal-democratic and key social and political concepts. Through our analyses of the discourse-conceptual dynamics surrounding the "conceptual flipsiding", we observe it as a long-lasting process wherein many of the (once) widely accepted core meanings of key liberal-democratic and other socio-political concepts are not only persistently diluted or weakened but often outright replaced with "new", illiberal understandings that eventually persist in both public discourse and in public imagination.}, issn = {1035-0330} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gerdinmarcus_2025, title = {Conceptual inconsistencies in variable definitions and measurement items within ISP non-/compliance research : A systematic literature review}, author = {Gerdin, Marcus and Grönlund, Åke and Kolkowska, Ella}, year = {2025}, journal = {Computers & Security}, volume = {152}, doi = {10.1016/j.cose.2025.104365}, url = {1944836}, language = {eng}, publisher = {Elsevier}, keywords = {information security policy; protection motivation theory; theory of planned behavior; variable properties; non-compliance}, abstract = {The rich stream of research focusing on employee non-/compliance with information security policies (ISPs) suffers from inconsistent results. Attempts to explain such inconsistencies have included investigation of possible contextual moderating factors. Another promising, yet not systematically investigated, explanation concerns conceptual inconsistencies in variable definitions and in questionnaire measurement items. Based on a systematic literature review covering 36 ISP non-/compliance articles using Protection Motivation Theory (PMT) and/or Theory of Planned Behavior (TPB), we found four major types of conceptual inconsistencies and unclarities within and across studies; (i) inconsistencies in variable definitions; (ii) inconsistencies between variable measurement items; (iii) inconsistencies between variable definitions and measurement items; and (iv) unclearly/vaguely worded measurement items. The review contributes to the field by demonstrating that the inconsistent results in the field may not only be due to unknown contextual moderators, but also to conceptual incongruences within and across studies.}, issn = {0167-4048} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_bergjacob_2025, title = {Conceptualising Proportionality and Criminal Sanctions in EU Law : Three Different Visions}, author = {Öberg, Jacob}, year = {2025}, pages = {9--24}, doi = {10.5040/9781509974184.ch-002}, url = {1935316}, language = {eng}, publisher = {Hart Publishing Ltd}, keywords = {eu law; eu criminal law; criminal justice; proportionality; penalties}, abstract = {The principle of proportionality is a key principle in EU law; however, it has distinctive meanings in different contexts. In the field of free movement, proportionality constrains the Member States’ possibilities to diverge from EU law on the basis of the requirement of suitability and necessity. In the area of EU competences it is a principle that guides the relationship between the EU and Member States and requires the EU legislator to use the least intrusive means of regulation/legislation to protect state sovereignty. There is also a third approach to proportionality in the field of EU sanctions and the Court of Justice’s case-law, which entails that the sanction imposed must be commensurate to the gravity of the offence. This more conventional criminal law ‘retrospective’ version of proportionality has now been enshrined in the Charter of Fundamental Rights and suggests that ‘the severity of penalties must not be disproportionate to the criminal offence’. }, file = {https://oru.diva-portal.org/smash/get/diva2:1935316/FULLTEXT03.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_arenasfr_2025, title = {Conclusion : Three levels to recapitulate Bergman's film-cultural relevance}, author = {Arenas, F.R. and Van Belle, Jono and Peirano, M.P.}, year = {2025}, pages = {215--221}, url = {2028594}, language = {eng}, publisher = {Berghahn Books} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_chanjoshuacc_2025, title = {Conditional forecasts in large Bayesian VARs with multiple equality and inequality constraints}, author = {Chan, Joshua C.C. and Pettenuzzo, Davide and Poon, Aubrey and Zhu, Dan}, year = {2025}, journal = {Journal of Economic Dynamics and Control}, volume = {173}, doi = {10.1016/j.jedc.2025.105061}, url = {1935913}, language = {eng}, publisher = {Elsevier}, keywords = {precision-based method; conditional forecast; vector autoregression}, abstract = {Conditional forecasts, i.e. projections of a set of variables of interest on the future paths of some other variables, are used routinely by empirical macroeconomists in a number of applied settings. In spite of this, the existing algorithms used to generate conditional forecasts tend to be very computationally intensive, especially when working with large Vector Autoregressions or when multiple linear equality and inequality constraints are imposed at once. We introduce a novel precision-based sampler that is fast, scales well, and yields conditional forecasts from linear equality and inequality constraints. We show in a simulation study that the proposed method produces forecasts that are identical to those from the existing algorithms but in a fraction of the time. We then illustrate the performance of our method in a large Bayesian Vector Autoregression. Within this setting, we first highlight how we can simultaneously impose a mix of linear equality and inequality constraints on the future trajectories of several key US macro economic indicators over a forecast horizon spanning multiple years. Next, we test the benefits of using inequality constraints in an out-of-sample exercise spanning the period between 1995Q1 and 2022Q3 and find that imposing these constraints on the future path of Real GDP leads to significant improvement in point and density forecasts of the large BVAR model.}, issn = {0165-1889} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sundhjosefin_2025_2, title = {Conducting a registry-based randomised trial (REDOX) in chronic respiratory failure : experiences and advice}, author = {Sundh, Josefin and Ekström, Magnus}, year = {2025}, journal = {European Clinical Respiratory Journal}, volume = {12}, number = {1}, doi = {10.1080/20018525.2025.2502237}, url = {1959267}, language = {eng}, publisher = {Co-Action Publishing}, keywords = {hospitalisation; hypoxemia; mortality; oxygen therapy; trial design}, abstract = {Registry-based randomised controlled trials (R-RCTs) represent a paradigm shift in research, with the potential to accomplish pragmatic but large trials with high external validity. In this paper, we review our experiences from planning and performing the REgistry-based randomised controlled trial of treatment Duration and mortality in long-term OXygen therapy (REDOX) trial, the first R-RCT within respiratory medicine. The REDOX study compared the two established treatment options of home oxygen 15 and 24 h per day. Previous recommendations to use oxygen for at least 15 h but preferably 24 h per day were based on a non-randomised comparison of two different studies. We hypothesised that oxygen 24 h/day was non-superior to 15 h/day and used the Swedish National Registry for Respiratory Failure (Swedevox) to perform an R-RCT showing that home oxygen 24 h/day does not improve survival, hospitalisation or patient-reported outcomes within 1 year. We describe the entire procedure of REDOX from planning to publication and use it to discuss challenges and potential solutions for future R-RCTs. In summary, common features of R-RCTs are the use of a registry for identification and randomisation of participants and for reporting and collecting baseline and outcome data, and the design is typically used to compare two treatment options. Important strengths are high generalisability, low cost, feasibility for consecutive recruitment in clinical practice, and high completeness of follow-up. Limitations include that coverage, completeness and accuracy of baseline data may differ between registries. Specific challenges (and solutions) in REDOX were addressing an important question (pragmatic clinical trials), management (clinical research support teams), costs (using registry-based infrastructure), different electronic data capture systems (posttrial linkage), slow recruitment (amendment of protocol) and resistance to challenge treatment traditions.}, issn = {2001-8525} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_weikuangyicharles_2025, title = {Conference report : The second Bacterial Genome Sequencing Pan-European Network conference}, author = {Wei, Kuangyi Charles and Purushothaman, Srinithi and Azzato, Francesca and Baker, Kate S. and Birkeland, Kira Waagner and Brunet, Sofia and Campos, Josefina and Connor, Thomas R. and Giske, Christian G. and Greub, Gilbert and Hallbäck, Erika Tång and Harmsen, Dag and Hodcroft, Emma B. and Holden, Matthew T. G. and Jacob, Jobin and Kahles, Andre and Campillay Lagos, Amaya and Lipworth, Samuel and Loo, Elin and Miotto, Paolo and Neher, Richard A. and Neves, Aitana and Ready, Derren and Roloff, Tim and Rooney, Ashley and Rousseau, Emilie and Schrenzel, Jacques and Sundqvist, Martin and Viegas, Sofia and Wegner, Fanny and Aamot, Hege Vangstein and Niemann, Stefan and Williamson, Deborah A. and Mölling, Paula and Egli, Adrian}, year = {2025}, journal = {Microbes and infection}, volume = {27}, number = {7}, doi = {10.1016/j.micinf.2025.105557}, url = {1991184}, language = {eng}, publisher = {Elsevier}, keywords = {antimicrobial resistance; data; diagnostics; education; pathogen identification; surveillance; whole genome sequencing; workshop}, issn = {1286-4579} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_czajkowskimarek_2025, title = {Conflicts of interest and industry funding declared in systematic reviews of interventions for six common diagnoses}, author = {Czajkowski, Marek and Olsson, Louise}, year = {2025}, journal = {Scandinavian Journal of Primary Health Care}, doi = {10.1080/02813432.2025.2519660}, url = {1979114}, language = {eng}, publisher = {Taylor & Francis}, keywords = {conflicts of interest; chronic disease; disclosure; primary health care; systematic reviews}, abstract = {BACKGROUND: There is a lack of data on the prevalence of conflicts of interest (COI) declared in systematic reviews over time.METHODS: PubMed was searched for systematic reviews on interventions for chronic obstructive pulmonary disease, type 2 diabetes mellitus, hypertension, dementia, major depression, and osteoarthritis from 2010 and 2019. Selection was conducted by two independent authors, with disagreements resolved in consensus. COI and funding disclosures were extracted. COI were categorised using a specific framework.RESULTS: 746 systematic reviews were included. One third involved pharmacological interventions. Systematic reviews from China increased from 4% to 21% between 2010 and 2019; Cochrane reviews decreased from 19% to 4%.Systematic reviews presenting a COI statement increased from 79% to 94%. Those with at least one author declaring individual financial COI decreased from 22% to 17% but remained at 22-23% when excluding systematic reviews from China. Almost 1 in 3 systematic reviews on pharmacological interventions and invasive procedures declared individual financial COI for 2019. Individual intellectual COI were declared in 2.5% and other types of COI were very rare.Systematic reviews presenting a funding statement increased from 65% to 81%; industry funding decreased from 6% to 3.4%. Adding industry funding to the prevalence of systematic reviews declaring financial COI only made a marginal difference.CONCLUSIONS: The proportion of systematic reviews on interventions for common diagnoses declaring individual financial COI remained consistent at approximately one in five for both 2010 and 2019, underscoring the need for further research into the implications of this finding.}, issn = {0281-3432} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_xus_2025, title = {Confundus : Mitigating Hostile Wireless Source Localization}, author = {Xu, S. and Wang, S. and Sciancalepore, S. and Brighente, A. and Conti, Mauro}, year = {2025}, doi = {10.1109/CNS66487.2025.11194176}, url = {2028797}, language = {eng}, publisher = {IEEE}, abstract = {According to privacy regulations, e.g., GDPR, location privacy is a fundamental right of mobile users, and it should be guaranteed that no unauthorized third-parties collect and retain such information. However, adversaries can leverage fully passive time-based physical layer approaches to stealthily multilaterate the location of wireless transmitters. As such techniques do not require any collaboration of the device being localized, they pose a remarkable location privacy threat. This problem has often been overlooked in the literature, and there currently exists no real-world validated solution to such attacks. In this paper, we propose Confundus, the first real-world validated solution for location privacy protection of RF devices. Our solution innovatively leverages Fake Multipath Injection (FMI) to exploit the main source of inaccuracy of state-of-the-art passive localization techniques, i.e., correct timestamp estimation. According to commonly implemented techniques for timestamp estimation, when receiving consecutive signal replicas, wireless receivers estimate as the reception timestamp of the overall signal the time at which the strongest replica is received. To cause wrong timestamp estimation at the attacker's nodes, Confundus emits several instances of the same short message at very close time instants, with the same transmission power. Due to the channel effect and the noise at the receiver, replicas arrive with different power at different receivers, thus causing wrong estimations. Our real-world experimental assessment, ran using Software-Defined Radios and an actual wireless localization system, demonstrates that by using only one additional replica we can increase the localization error from a few meters to a few kilometers.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lagaresalfonso_2025, title = {Consensus on the management of traumatic brain injury in older adults : Results from a Delphi study}, author = {Lagares, Alfonso and Depreitere, Bart and Marklund, Niklas and Castano Leon, Ana María and Posti, Jussi P. and Younsi, Alexander and Klein, Sam}, year = {2025}, journal = {Brain and Spine}, volume = {5}, doi = {10.1016/j.bas.2025.104319}, url = {1991647}, language = {eng}, publisher = {Elsevier}, keywords = {aged; clinical management; diagnosis; outcome; traumatic brain injury; consensus}, abstract = {INTRODUCTION: As the world population is rapidly becoming older, the incidence of traumatic brain injury (TBI) is increasing among older adults with vast implications for brain health of older adults in Europe. Due to differences from younger patients, there are areas of uncertainty in the assessment, diagnosis and management of TBI in older adults.RESEARCH QUESTION: To reach a consensus among experts on statements regarding the definition of old age, assessment, diagnosis and management of traumatic brain injury in older adults.MATERIALS AND METHODS: A modified Delphi method consisting of two online rounds was organised, followed by an in-person meeting. Consensus was defined as >75 % agreement. In the second online round the experts were able to view their first assessment and the average of the group. Some statements were rephrased and presented again in the in-person meeting. Questions with numerical data could not be assessed by consensus and descriptive and non-parametric statistics were used to analyze them.RESULTS: Experts (n = 72), from different nationalities (Europe, United States, Latin America, Africa and Asia) and specialities (Neurosurgery, Emergency Medicine, Intensive care medicine) responded on 62 statements. Consensus was finally reached on 44 statements regarding the definition of older adulthood, as well as the assessment, surgical and intensive care management, discharge, and rehabilitation of patients.DISCUSSION AND CONCLUSIONS: This consensus reinforces the importance of this area for physicians and researchers interested in traumatic brain injury. It signals important areas of agreement as well as future topics for research and specific knowledge gaps.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kauskotalexandre_2025, title = {Consensus protocol for platelet desialylation (β-galactose exposure) quantification using lectins by flow cytometry : Communication from the ISTH SSC Subcommittee on Platelet Physiology}, author = {Kauskot, Alexandre and Ramström, Sofia and Nipoti, Thomas and van der Wal, Dianne E.}, year = {2025}, journal = {Journal of Thrombosis and Haemostasis}, volume = {23}, number = {6}, pages = {2050--2059}, doi = {10.1016/j.jtha.2025.03.017}, url = {1948210}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {blood platelets; desialylated glycoproteins; desialylation; diagnosis; flow cytometry; galactose; glycans; platelets; sialic acid}, abstract = {Background: Platelets contain many heterogeneous carbohydrates (glycans), often capped by sialic acid. The removal of sialic acid (desialylation) is important for platelet function and clearance, leading to novel diagnostic markers. Platelet desialylation can be easily measured using inexpensive, user-friendly lectins, and flow cytometry.Objectives: Here, the Platelet Physiology Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis (ISTH) carried out a survey to assess current methods used for platelet desialylation. Based on the survey results, a consensus protocol was drafted and tested.Methods: A survey/questionnaire was posted on the ISTH Platelet Physiology Standardization Committee pages. Washed platelets and diluted apheresis platelets were diluted to 50 and 200 x 106/mL +/- CaCl2. Platelets were stained with a concentration range of either beta-galactose binding fluoresceine-conjugated lectin Ricinus communis agglutinin 1 (RCA-1) or Erythrina cristagalli lectin (ECL). As positive controls, different recombinant sialidases were tested.Results: The results of the survey (N = 20) showed that flow cytometry and RCA-1 are mostly used to assess platelet desialylation. Calcium did not significantly influence lectin binding, and optimal binding was achieved with ECL and RCA-1 at 2 and 5 mu g/mL, respectively. The specificity of lectins varied, particularly after sialidase treatment, compared with cold-stored platelets. These findings contribute to the standardization of desialylation measurements, particularly in patient samples.Conclusion: Our findings demonstrate that flow cytometry using RCA-1 and ECL is a robust method for quantifying platelet desialylation. The proposed standardized protocol addresses key preanalytical variables, enabling reproducible and accurate analysis of platelet glycosylation.}, issn = {1538-7933} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_sandelinlisa_2025, title = {Consent in Child Welfare Investigations of Suspected Child Abuse}, author = {Sandelin, Lisa}, year = {2025}, url = {1997966}, language = {eng} } @book{ca0f099bbf2a435cee8f97bef5e8cbaa_nergeliusjoakim_2025_1, title = {Constitutional Law in Sweden}, author = {Nergelius, Joakim}, year = {2025}, url = {2032343}, language = {eng}, publisher = {Kluwer Law International}, keywords = {swedish constitution; structure; electoral system; legislation; fundamental rights; judicial systems}, abstract = {A rather detailed description of the Swedish constitution, aimed mainly at foreign readers} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dahlbergmaija_2025, title = {Constitutional law in the Finnish Supreme Courts : The role of preparatory works and precedents in constitutional interpretation}, author = {Dahlberg, Maija and Kelemen, Katalin}, year = {2025}, journal = {Retfærd: Nordisk Juridisk Tidsskrift}, number = {1}, pages = {27--43}, url = {1956894}, language = {eng}, publisher = {DJØF Forlag}, keywords = {constitutional reasoning; preparatory works; precedents; finland; comparative law; empirical research; finnish supreme courts; constitutional interpretation}, abstract = {In this article, we analyze constitutional interpretations in the leading constitutional cases bythe Finnish Supreme Court (Korkein oikeus) and the Finnish Supreme Administrative Court (Korkeinhallinto-oikeus), paying particular attention to the use of preparatory works and precedents in constitutionalinterpretations. The article is based on an empirical comparative study in which we analyze theconstitutional reasoning of the Nordic Supreme Courts, using quantitative methods. The article showsthat the Finnish courts (and Nordic courts in general) use legislative intent as an independent argument,a practice that is uncommon outside the Nordics. In addition, the article demonstrates that Finnish courtstend to lack confidence in their own authority, placing greater trust in the Constitutional Law Committeeand exercising self-restraint in constitutional adjudication. Finally, challenges relating to the courts’ deferentialand cautious approach to constitutional interpretation are highlighted.}, issn = {0105-1121} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssonelin_2025, title = {Construct validity, internal consistency and test-retest reliability of the Swedish version of the Hearing and Functioning in Everyday Life Questionnaire (HFEQ)}, author = {Karlsson, Elin and Ramesh, Meenakshi and Dahlström, Örjan}, year = {2025}, journal = {International Journal of Audiology}, pages = {1--13}, doi = {10.1080/14992027.2025.2577711}, url = {2012137}, language = {eng}, publisher = {Taylor & Francis Group}, keywords = {audiological rehabilitation; icf; everyday functioning; hearing loss; outcome measure; psychometric evaluation; validation}, abstract = {OBJECTIVE: The overall aim of this study was to evaluate the construct validity, internal consistency and test-retest reliability of the Swedish version of the Hearing and Functioning in Everyday Life Questionnaire (HFEQ-SWE). The aim was to investigate how adults with hearing loss experience their everyday functioning from the perspective of hearing, using the HFEQ-SWE. DESIGN AND STUDY SAMPLE: A quantitative cross-sectional survey study with 628 adults, aged 30-96 years (mean 74.4, SD = 10.3) recruited from audiological clinics in three counties of Sweden. The factor structure of the HFEQ was examined by confirmatory factor analysis via comparisons with the 6 subscales of the HFEQ: health, hearing, communication, participation in society, individual resources and societal support. HFEQ ratings were compared for the following variables: sex, level of education, employment and hearing aid usage.RESULTS: With some modifications of the original HFEQ structure, a CFA showed sufficient model fit and confirmed the HFEQ construct. The internal consistency for the total score was satisfactory, and the correlations between repeated measurements showed stability over time for the total score. There were variations at item level and subscale levels. We identified broad variations in HFEQ ratings and found that the experience of everyday functioning is associated with factors such as age, gender, level of education, employment, and hearing aid usage. Significant correlations were found between self-reported hearing loss and 79% of the HFEQ items.CONCLUSION: The overall study results strengthen the validity and reliability of the HFEQ and indicate satisfactory construct validity, internal consistency and test-retest reliability for the total score. Some items need further attention. Differences in the HFEQ rating were found at the item level for the variables of age, gender, education, employment, and hearing aid use, suggesting that these factors affect everyday functioning in addition to hearing loss.}, issn = {1499-2027} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_auerj_2025, title = {Consumer preferences of plant-based minced meat analogs : Linking physico-chemical properties, structural features, and sensory attributes}, author = {Auer, J. and Kim, Ansung and Heupl, S. and Mihnea, Mihaela and Öström, Åsa and Niimi, J. and Langton, M.}, year = {2025}, journal = {Food Structure}, volume = {46}, doi = {10.1016/j.foostr.2025.100492}, url = {2028228}, language = {eng}, publisher = {Elsevier}, keywords = {consumer; fiber structure; food microstructure; computed tomography (ct); sensory properties}, abstract = {Plant-based food products offer a sustainable option for consumers seeking to reduce meat intake while maintaining the sensory satisfaction similar to conventional meat. However, the products in question are still unsatisfactory, and simulating the sensory properties that consumers find palatable remains significantly challenging. This study investigated the physicochemical and sensory properties of plant-based minced meat analogs, with an emphasis on texture (including texture profile analysis (TPA), liquid holding capacity (LHC), and fiber orientation) and appearance (color and particle size). Four commercial plant-based products were evaluated: two soy-based (Soy Ⅰ and Soy Ⅱ) and two pea-based (Pea Ⅰ and Pea Ⅱ) to elucidate the relationship between microstructural features and consumer sensory perception. TPA results indicated that soy-based products exhibited significantly higher hardness, gumminess, and chewiness compared to pea-based products. LHC and colour analyses revealed notable differences among the samples: Pea I showed the lowest mass loss, indicating superior water retention, while Pea II displayed pronounced red and yellow colour values. Particle size analysis indicated that Pea II and Soy I contained larger and more heterogeneous particles, whereas Soy II was characterized by smaller and more uniform particulates. Further, fiber orientation analysis revealed that Soy II exhibited more aligned fiber structures, which may contribute to its higher mechanical resistance and firmness. Sensory evaluation indicated consumer preference for Soy II, which was perceived as chewier and more rubbery in texture. The overall pattern from sensory evaluation was consistent with instrumental measurements, underscoring the utility of structural and mechanical analyses in predicting consumer acceptance. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karimzadehsara_2025_1, title = {Consuming with care : insights into ethical consumption in Iran}, author = {Karimzadeh, Sara}, year = {2025}, journal = {Frontiers in Sustainability}, volume = {6}, doi = {10.3389/frsus.2025.1540113}, url = {1984221}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {care; mindful consumption; iran; local moralities; everyday ethics}, abstract = {This study examines the meanings and practices of ethical consumption in Iran, enriching dominant narratives that link ethical consumption primarily to institutional frameworks or environmental discourses. It argues that ethical considerations are instead embedded in local cultural, spiritual, and social norms. The research draws on 19 in-depth qualitative interviews with urban residents in the midsized city of Urmia. A thematic analysis was employed to understand participants’ practices across three stages of consumption: pre-consumption, consumption, and post-consumption. In the pre-consumption stage, structural constraints—such as limited access to reliable information and economic precarity—define the boundaries of ethical choices. The consumption stage is primarily influenced by sufficiency-oriented ethic through the avoidance of heyf-o-meyl (wastefulness and unnecessary consumption), reflecting values rooted in traditional and cultural teachings. In the post-consumption stage, the practice of ehsan kardan (acts of care and generosity) emerged as a key form of ethical divestment that minimizes waste and supports others in need. The study reveals that participants conceptualize ethical consumption through human-centered values—such as care, responsibility, and generosity—rather than through environmentalism or formal regulation. The results contribute to the literature on sustainable consumption by highlighting culturally embedded, locally meaningful forms of ethical engagement that constitute a moral micro-economy.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lidstrmholmqvistkajsa_2025, title = {Content and outcome of non-pharmacological rehabilitation in hospital, or community-based care, for women with traumatic brain injury : a scoping review protocol}, author = {Lidström-Holmqvist, Kajsa and Strandberg, Thomas and Simpson, Grahame and Massey, Jessica and Matérne, Marie}, year = {2025}, journal = {BMJ Open}, volume = {15}, number = {1}, pages = {e092767}, doi = {10.1136/bmjopen-2024-092767}, url = {1926381}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {adult neurology; behavior}, abstract = {INTRODUCTION: Traumatic brain injury (TBI) is a global health issue and a leading cause of long-term disabilities and mortality worldwide. There is growing evidence that TBI rehabilitation should be differentiated and individualised according to gender to provide more effective healthcare and rehabilitation. However, there is a lack of reviews focusing on the rehabilitation for women with TBI and there is a need to summarise existing knowledge to guide and individualise their rehabilitation. This scoping review aims to identify and map evidence on content and outcome of non-pharmacological rehabilitation for women with TBI aged below 65 years.METHODS AND ANALYSIS: This scoping review will follow the methodological guidelines of the Joanna Briggs Institute (JBI) and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR). The databases searched will be PubMed, CINAHL and PsycINFO. The following inclusion criteria will be applied: peer-reviewed studies published in English over the years 2000-2024 including description of content and outcomes of non-pharmacological TBI rehabilitation for women aged between 16 and 65 years in both inpatient and outpatient contexts. All severities of TBI ranging from concussion through to extremely severe will be included. Text and opinion papers, conference abstracts and grey literature will be excluded. Studies fulfilling the inclusion criteria will be independently reviewed by three researchers. A data extraction form will be used including specific details about the participants, concept, context, study methods and key findings. The results will be presented in tabular format accompanied by a narrative summary.ETHICS AND DISSEMINATION: Due to the nature of data, no approval from an ethics committee is required. Dissemination of results are planned in an open-access peer-reviewed journal and in professional networks.REVIEW REGISTRATION NUMBER: OSF, https://doi.org/10.17605/OSF.IO/QUY3T.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_winbergmadeleine_2025, title = {Contextual Factors Affecting Evidence-Based Practice in Orthopaedic Nursing and Rehabilitation : A Mixed Methods Study}, author = {Winberg, Madeleine and Fjordkvist, Erika and Joelsson-Alm, Eva and Carlfjord, Siw and Hälleberg Nyman, Maria and Eldh, Ann Catrine}, year = {2025}, journal = {Journal of Advanced Nursing}, doi = {10.1111/jan.70098}, url = {1986544}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {bladder care; context; evidence-based practice; facilitation; hip surgery; implementation; orthopaedic care}, abstract = {Aim: To better understand what enables evidence-based practice, this study investigated contextual factors influencing evidence-based practice in general, and in relation to the implementation of bladder-monitoring guidelines in orthopaedic care.Design: Convergent parallel mixed method.Methods: This study was part of a hybrid research project across 17 Swedish orthopaedic sites. The data collection (2021-2023) included interviews with orthopaedic staff and patients post-hip surgery, patient survey free-text responses, and a staff survey on organisational context. Data were analysed with deductive content analysis and descriptive statistics, later integrated using a mixed methods approach.Results: Evidence-based practice was supported by context factors such as staff collaboration and multiprofessional engagement. Staff addressed patient safety and equality by using evidence-based guidelines, but rarely involved the patients. Orthopaedic fast-track procedures positioned patients as passive recipients, while staff voiced a call for a more person-centred context. Positive attitudes, leadership engagement, use of champions, and adequate staffing enabled evidence-based practice, though a shortage in evaluation and high staff turnover hindered its implementation.Conclusion: Orthopaedic context is characterised by several enabling organisational context factors for evidence-based practice, although patients lacking recognition of their needs and queries justify greater focus on person-centredness and mutual information exchange. Audit and feedback are crucial for improvements, but were lacking in the orthopaedic care context.Implications for the Profession and/or Patient Care: Assessments of efforts made to implement evidence-based practice and its outcomes should incorporate nursing care. Slimmed care processes require attention to ensure patient participation.Impact: The orthopaedic care context is enabling for evidence-based practice, although staff are challenged by fast-track procedures with extensive information exchange and insufficient person-centredness.Reporting Method: The Mixed Methods Reporting in Rehabilitation & Health Sciences checklist.Patient or Public Involvement: No patient or public contribution.Trial Registration: Identifier: NCT 04700969}, issn = {0309-2402} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hodzabeganovicruhija_2025, title = {Contextualizing interprofessional competencies in the Balkans : Healthcare workers’ understanding of the concepts based on an existing framework and a self-report instrument}, author = {Hodza-Beganovic, Ruhija and Berggren, Peter and Edelbring, Samuel}, year = {2025}, journal = {Journal of Interprofessional Education and Practice}, volume = {41}, doi = {10.1016/j.xjep.2025.100787}, url = {2028077}, language = {eng}, publisher = {Elsevier}, keywords = {contextualization; interprofessional competence; mokken scale analysis; self-report}, abstract = {This paper emphasizes adapting frameworks for interprofessional collaboration (IPC) from high-income settings to culturally distinct, resource-constrained regions. We adapted and validated the Interprofessional Education Collaborative (IPEC) competency framework within a Balkan healthcare context facing systemic, educational, and financial challenges. Frameworks such as IPEC may not fully capture contextual nuances in lower-middle-income countries (LMICs). Therefore, we examined how the IPEC framework could be culturally adapted for healthcare workers in the Balkans. A convergent mixed-methods design was employed, involving two interprofessional workshops and a follow-up survey. Healthcare workers from Bosnia and Herzegovina, Montenegro, and Kosovo participated in reflective discussions and prioritized competencies from the original 38-item IPEC instrument. The adapted instrument (IPEC-21B) was evaluated for psychometric reliability and contextual relevance and proved to be both valid and practical due to its shorter format. The instrument measured attitudes toward IPC and encouraged critical dialogue about hierarchy, communication, and shared roles, positioning it as both an assessment tool and a catalyst for professional learning. The results demonstrate how an adapted survey on IPC foster systemic thinking and professional development provides a tool for increased awareness. By retaining all core IPEC domains, IPEC-21B provides a tool for increasing awareness and developing interprofessional competencies in a way that aligns with local cultural and educational needs in settings with limited traditions of interprofessional practice. Tailoring an IPC instrument to local contexts enhances healthcare workers’ understanding of collaboration and may improve patient outcomes and care equity. The participatory adaptation process emphasizes embedding dialogue and shared understanding into interprofessional education and assessment in LMICs.}, issn = {2405-4526} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_davinogabriella_2025, title = {Continuing the conversation : Integration research futures}, author = {D'Avino, Gabriella and Nicholls, Natasha and Lutz, Ryan and Amouri, Layan and Khin, Ame}, year = {2025}, url = {2002362}, language = {eng}, abstract = {Building on prior discussions led by the Centre for Refugee Studies at York University and the Institute for Research into Superdiversity at the University of Birmingham, this workshop delves further into the complex and debated concept of ‘integration’ within migration studies. Despite numerous critiques, ‘integration’ continues to lack a clear, universally accepted definition. While various alternative terms have been suggested, they tend to face similar conceptual challenges, leaving uncertainties regarding their effectiveness in addressing the criticisms levelled at integration (Spencer, 2022). Yet, ‘integration’ remains central to policy and practical discourse (Klarenbeek, 2021; Vertovec, 2020), particularly in the context of refugees, where the success of long-term solutions to displacement is often measured by the degree of refugee integration within communities (Bornstein, 2017; Hynie, 2018). Previous discussions have focused on the functional aspects of integration, such as employment, education and access to health services (Grzymala-Kazlowska and Phillimore, 2018), seen as both policy priorities and key to refugee-wellbeing (Mestheneos and Ioannidi, 2002). However, there is a critical gap in addressing the emotional dimensions of integration, such as belonging, safety and fulfilment. Given that the number of displaced people has more than doubled in the past decade (UNHCR, 2023), understanding the factors that contribute to positive integration experiences is more urgent than ever. This workshop aims to build on earlier insights, continuing the conversation on the future of integration by exploring its functional and emotional dimensions, thus enriching our understanding of how successful integration can be facilitated. The objectives of this second workshop are threefold. First, participants will collaboratively identify and discuss the primary themes and challenges related to decentering integration; second, the workshop will encourage the exploration of alternative methodologies for studying integration, moving beyond traditional methods such as interviews and surveys to incorporate creative, visual and participatory techniques to challenge from where and by who knowledge is produced; and third, the workshop will provide a space for creating connections and pathways to impact for researchers and practitioners that can shape future research and advocacy efforts. By employing a multidisciplinary, decentered approach, this workshop seeks to shape research agendas that align with both policy needs and the aspirations of refugees and people seeking asylum. Through advancing more innovative methods and fostering collaboration within the field, we aim to inform policies that prioritize the voices and experiences of refugees, strengthening a deeper, more inclusive understanding of integration.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kessonmaria_2025, title = {Contraceptive choices and satisfaction : a cross-sectional analysis of sociodemographic influences}, author = {Åkesson, Maria and Brynhildsen, Jan and Tydén, Tanja and Envall, Niklas and Backman, Helena and Skogsdal, Yvonne Rosalie Elisabeth}, year = {2025}, journal = {Upsala Journal of Medical Sciences}, volume = {130}, doi = {10.48101/ujms.v130.12656}, url = {1990314}, language = {eng}, publisher = {Upsala Medical Society}, keywords = {contraception; birth control; long-acting reversible contraceptives; patient satisfaction; sociodemographic factors}, abstract = {INTRODUCTION: Investigating factors associated with contraceptive satisfaction is important to create a basis for tailored contraceptive counseling. In this study, we aimed to explore how sociodemographic characteristics affected women's level of satisfaction and choice of different contraceptive methods, using data collected during a randomized controlled trial (RCT) in the region Örebro County, Sweden.METHODS: This cross-sectional study utilized data from a previously conducted RCT. Eligible participants were women aged 20-40 years who sought contraceptive counseling. All women who participated in the RCT and completed a follow-up questionnaire were included in the analysis.RESULTS: Between February 2015 and March 2016, 1,946, participants were enrolled in the trial, with 1,198 (61.6%) completing the 2-month follow-up questionnaire. Overall, 81.3% of women reported being 'very satisfied' or 'satisfied' with their contraceptive method. Participants aged 27-40 years used long-acting reversible contraception (LARC) to a higher extent compared with those aged 20-26 years (adjusted odds ratio [aOR] 1.92, 95% confidence interval [CI] 1.44-2.56). Older age was associated with lower satisfaction (aOR 0.55, 95% CI 0.33-0.94).Participants with a body mass index (BMI) ≥ 25 more often used LARC (aOR 1.68, 95% CI 1.24-2.28) but were also more likely to report no use of contraceptives at all (aOR 1.56, 95% CI 1.01-2.43) compared with BMI < 25. The level of satisfaction tended to decrease with increasing BMI. Country of birth and educational level were not associated with satisfaction.CONCLUSIONS: The use of LARC was more common among women with BMI ≥ 25 and older women. While BMI, education, and place of birth did not affect satisfaction, women aged 27-40 reported lower satisfaction. These findings contrast with prior studies and highlight the complex sociodemographic influences on contraception experiences.}, issn = {0300-9734}, file = {https://oru.diva-portal.org/smash/get/diva2:1990314/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_petterssonpablopaul_2025, title = {Contraceptive use, both oral and parenteral, is associated with increased arterial stiffness in young healthy women}, author = {Pettersson-Pablo, Paul and Nilsson, Torbjörn K. and Hurtig-Wennlöf, Anita}, year = {2025}, journal = {Endocrine}, volume = {88}, number = {3}, pages = {739--746}, doi = {10.1007/s12020-025-04208-9}, url = {1944539}, language = {eng}, publisher = {Springer}, keywords = {contraceptive; menstrual phase; pulse-wave velocity; shbg; young female adults; cimt}, abstract = {PURPOSE: Previous studies on the impact on arterial health of contraceptive use, or across the menstrual phases, have yielded differing results. Furthermore, there is little research on the differences based on the delivery method of the contraceptive, oral vs parenteral contraceptives. In this study, we examined arterial health using three different physiological measures of arterial function and structure in contraceptive users and non-users.METHODS: Young, healthy women, between 18.0-25.9 years of age were enrolled in the study (n = 577). Menstrual phase and contraceptive use and type were assessed by questionnaire. Arterial stiffness was measured using pulse-wave velocity (PWV) and augmentation index (AIx). Arterial thickness was measured using carotid-intima media thickness (cIMT). Blood samples were analysed for various biomarkers, which were used in multivariate regressions to adjust for the effects of contraceptive use on vascular status.RESULTS: Contraceptive users had a higher PWV than non-users. The menstrual phase did not impact PWV. In a smaller subgroup analysis, comparing the types of contraceptives, oral or parenteral, did not impact PWV. AIx and cIMT did not differ significantly between any studied groups. Systolic blood pressure, BMI, serum lipids, C-reactive protein, and sex hormone binding globulin concentrations were higher in the contraceptive using group, but in multivariable models, these biomarkers had only limited impact on the association between contraceptive use and PWV.CONCLUSION: In a population of young, healthy women, contraceptive users displayed higher PWV values. The effect could not be explained by the effect of contraceptives on androgenicity, blood pressure or lipids.}, issn = {1355-008X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zattarinelisa_2025, title = {Controlled release of antimicrobial peptides from nanocellulose wound dressings for treatment of wound infections}, author = {Zattarin, Elisa and Sotra, Zeljana and Wiman, Emanuel and Bas, Yagmur and Rakar, Jonathan and Berglund, Linn and Starkenberg, Annika and Björk, Emma M. and Khalaf, Hazem and Oksman, Kristiina and Bengtsson, Torbjörn and Junker, Johan P. E. and Aili, Daniel}, year = {2025}, journal = {Materials today. Bio}, volume = {32}, doi = {10.1016/j.mtbio.2025.101756}, url = {1955121}, language = {eng}, publisher = {Elsevier}, keywords = {antimicrobial peptides; bacteriocin; nanocellulose; plnc8; wound dressing; wound infection}, abstract = {Wounds are highly prone to infection, which can delay healing and lead to severe complications such as gangrene and sepsis. Non-healing wounds significantly impact patients' physical and mental well-being and place a substantial financial burden on healthcare systems. Timely and effective treatment of wound infections is critical, but the rise of antibiotic-resistant pathogens complicates this process. In this study, we investigate a potent protease resistant antimicrobial peptide (AMP), PLNC8 αβ, for the treatment of wound infections and present a strategy for localized AMP delivery using functionalized advanced nanocellulose (NC) wound dressings. Two types of NC dressings were explored: bacterial cellulose (BC) and TEMPO-oxidized nanocellulose derived from wood powder (TC). In a porcine wound infection model, PLNC8 αβ exhibited high antimicrobial activity, successfully eradicating the infection while promoting wound re-epithelialization. To achieve controlled release of PLNC8 αβ from the NC dressings, the peptides were either physisorbed directly onto the nanofibrils or encapsulated within mesoporous silica nanoparticles (MSNs) that were incorporated into the dressings. The PLNC8 αβ functionalized dressings demonstrated low cytotoxicity toward human primary fibroblasts and keratinocytes. Both BC and TC dressings showed efficient contact inhibition of bacteria but were less effective in inhibiting bacteria in suspension. In contrast, MSN-functionalized dressings, displayed significantly enhanced peptide-loading and sustained release capacities, resulting in improved antimicrobial efficacy. These findings highlight the potential of PLNC8 αβ and PLNC8 αβ-functionalized nanocellulose wound dressings for the treatment of infected wounds, offering an effective alternative to conventional antibiotic therapies.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zattarinelisa_2025_1, title = {Controlled release of antimicrobial peptides from nanocellulose wound dressings for treatment of wound infections}, author = {Zattarin, Elisa and Sotra, Zeljana and Wiman, Emanuel and Baş, Yağmur and Rakar, Jonathan and Berglund, Linn and Starkenberg, Annika and Björk, Emma and Khalaf, Hazem and Oksman, Kristiina and Bengtsson, Torbjorn and Junker, Johan and Aili, Daniel}, year = {2025}, journal = {Tissue Engineering. Part A}, volume = {31}, number = {11-12}, pages = {E921--E921}, url = {2007578}, language = {eng}, publisher = {Mary Ann Liebert}, abstract = {Introduction/Objectives: Wound infections are a major clinical challenge, often leading to severe complications and impeding the normal healing process, thereby resulting in chronic, non-healing wounds. These wounds impose a profound physical and psychological burden on patients while significantly increasing healthcare costs. Effective and timely treatment of wound infections is imperative; however, the escalating prevalence of antibiotic-resistant pathogens complicates infection management. This study aims to evaluate the antimicrobial efficacy of the potent two-peptide bacteriocin PLNC8 αβ for treating wound infections and to develop a localized delivery system using advanced functionalized nanocellulose (NC) wound dressings.Methods: The in vivo efficacy of PLNC8 αβ was evaluated using an infected porcine wound model. To develop a system for controlled release of PLNC8 αβ, two types of nanocellulose-based wound dressings were investigated: bacterial cellulose (BC) and TEMPO-oxidized nanocellulose derived from hardwood (TC). To endow the dressings with antimicrobial properties, they were functionalized with PLNC8 αβ. Functionalization with PLNC8 αβ was achieved by either direct physisorption onto the nanocellulose fibrils or by encapsulation within mesoporous silica nanoparticles (MSNs), which were integrated into the BC dressings.Results: In a porcine wound infection model, PLNC8 αβ effectively eradicated bacterial infections while promoting re-epithelialization. The PLNC8 αβ functionalized dressings demonstrated low cytotoxicity toward human primary fibroblasts and keratinocytes. Both BC and TC dressings demonstrated robust contact-based antibacterial activity but exhibited limited efficacy against bacteria in suspension. MSN-functionalized BC dressings significantly improved peptide-loading capacity and provided sustained release of PLNC8 αβ, leading to superior antimicrobial performance.Conclusions: This study underscores the potential of PLNC8 αβ for treatment of wound infections and demonstrates PLNC8 αβ functionalized nanocellulose wound dressings as an innovative therapeutic approach for managing infected wounds. By combining potent antimicrobial activity with advanced delivery mechanisms, this platform offers a promising alternative to conventional antibiotic treatments, addressing the growing challenge of antibiotic resistance.}, issn = {1937-3341} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssonelin_2025_1, title = {Convergent Validity and Test-Retest Reliability of the Swedish Version of the Empowerment Audiology Questionnaire}, author = {Karlsson, Elin and Larsson, Josefina and Yngve, Moa}, year = {2025}, journal = {Journal of Speech, Language and Hearing Research}, volume = {68}, number = {12}, pages = {6172--6181}, doi = {10.1044/2025_JSLHR-25-00327}, url = {2013769}, language = {eng}, publisher = {American Speech-Language-Hearing Association}, abstract = {PURPOSE: Hearing loss affects communication and participation. Empowerment initiatives support individuals to manage their condition and facilitate patient-centered care. The Empowerment Audiology Questionnaires (EmpAQ-15/5), recently translated and validated in Swedish (EmpAQ SWE), were evaluated for convergent validity, internal consistency, and test-retest reliability. This study evaluates the convergent validity, internal consistency, and test-retest reliability of EmpAQ SWE.METHOD: A total of 136 adults with hearing loss completed an online survey twice. The survey consisted of EmpAQ-SWE and five measures assessing hearing disability, everyday functioning, hearing aid benefit, and general disability. For analysis, Spearman's correlation coefficient and Cronbach's alpha were used.RESULTS: There were significant correlations between the EmpAQ SWE and measures of hearing disability (r = -.389), everyday functioning (r = -.350), and hearing aid benefit (r = .542 and r = -.326). There were no significant correlations between the EmpAQ and general disability. The test-retest results for the EmpAQ-SWE indicated strong reliability (r = .760) and moderate internal consistency (α = .678).CONCLUSIONS: EmpAQ SWE demonstrated positive associations with everyday functioning and hearing aid benefit and negative associations with hearing disability. Although causality cannot be established, the findings support the convergent validity and reliability of EmpAQ SWE, underscoring its potential utility in clinical and research contexts.}, issn = {1092-4388} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_westlingmagnus_2025, title = {Cooks as collaborative creators and evaluators : An iterative sensory-driven workshop to create vegetarian dishes}, author = {Westling, Magnus and Baptista, Iuri Yudi Furukita and Kim, Ansung and Engelheart, Stina and Berg, Pernilla and Öström, Åsa}, year = {2025}, journal = {The International Journal of Food Design}, volume = {10}, number = {1}, pages = {87--108}, doi = {10.1386/ijfd_00079_1}, url = {1996425}, language = {eng}, publisher = {Intellect Ltd.}, keywords = {check-all-that-apply; culinary funnel; cultivated diversity; familiarity; gastronomic potential; plant-based proteins; public meals; recipe development}, abstract = {Among the obstacles to substituting animal-based food products with more sustainable plant-based alternatives at home and in food service is the lack of familiarity and creativity among consumers and culinary professionals. This case study describes and discusses the designing of a two-day hands-on workshop for eighteen cooks from Örebro Municipality, Sweden. In a collaborative design process, participants experimented with eight vegetable ingredients (legumes, grains and plant-based meat alternatives) and different cooking techniques (e.g. baking, grilling and frying) to create thirteen novel or adapted vegetarian dishes. The workshop incorporated sensory assessments of the plain ingredients, the cooked ingredients and the final dishes, empowering cooks as both creators and evaluators and generating valuable data for future recipe development. The resulting dishes, ranging from light to hearty and simple to complex, indicated no correlation between the number of components and overall liking, challenging the common perception that vegetarian dishes require more effort, ingredients or complexity. A follow-up questionnaire and group interview provided insights into the workshop’s impact and potential improvements. The case of this workshop sparks broader discussions about how to create dishes by taking ingredients as a starting point, and how methods from sensory science can be used to improve the flavour of vegetarian meals. It also raises questions about how researchers can design more horizontal and collaborative interactions with other actors of society – such as, in this case, cooks working in public meal services.}, issn = {2056-6522} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wangjuan_2025, title = {COPD disease burden in relation to having FEV1/FVC ratio below lower limit of normal or fixed ratio}, author = {Wang, Juan and Ställberg, Bjorn and Hårdstedt, Maria and Bröms, Kristina and Farkhooy, Amir and Palm, Andreas and Lisspers, Karin and Högman, Marieann and Malinovschi, Andrei}, year = {2025}, journal = {European Respiratory Journal}, volume = {66}, number = {Suppl. 69}, doi = {10.1183/13993003.congress-2025.PA5772}, url = {2039021}, language = {eng}, publisher = {European Respiratory Society}, issn = {0903-1936} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kapetanakistefania_2025, title = {Correlations Between Trimethylamine-N-Oxide, Megalin, Lysine and Markers of Tubular Damage in Chronic Kidney Disease}, author = {Kapetanaki, Stefania and Salihovic, Samira and Kumawat, Ashok Kumar and Massy, Ziad A. and Persson, Katarina and Barany, Peter and Stenvinkel, Peter and Evans, Marie and Demirel, Isak}, year = {2025}, journal = {Toxins}, volume = {17}, number = {12}, doi = {10.3390/toxins17120592}, url = {2024441}, language = {eng}, publisher = {MDPI}, keywords = {tmao; albuminuria; chronic kidney disease; lysine; megalin; tubular damage}, abstract = {Trimethylamine-N-oxide (TMAO), a gut microbiota-derived dietary metabolite, is linked to progression of chronic kidney disease (CKD). Megalin, a renal proximal tubule receptor crucial for albumin reabsorption, also plays a role in CKD. However, the relationship between them is not well explored. The aim of this study was to investigate if there are any correlations between the levels of TMAO, megalin, lysine and markers of tubular damage in CKD. Urinary metabolites (TMAO, choline, L-carnitine, betaine, lysine) and tubular markers (megalin, albumin, EGF, MCP-1) were quantified by LC-MS/MS and ELISA. Associations were evaluated using analysis of covariance (ANCOVA) adjusted for age and diabetes, with false discovery rate correction. Compared with controls, CKD patients showed higher urinary choline (FDR < 0.001), betaine (FDR = 0.007), lysine (FDR = 0.005), and soluble megalin (FDR < 0.001) but lower EGF and EGF/MCP-1 ratio (both FDR < 0.001). Correlation analyses revealed that serum TMAO was positively associated with soluble megalin and negatively with EGF/MCP-1 ratio. Choline, L-carnitine, and betaine were positively correlated with megalin. This cross-sectional study identifies associations between urinary metabolites, megalin, and tubular injury markers in advanced CKD. Although causality cannot be inferred, the results point to a potential metabolic-tubular link that should be explored in future longitudinal and mechanistic studies.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_visurii_2025, title = {Correlations of clinical characteristics and serum proteins with drug levels : A multicentre cohort study of patients with inflammatory bowel disease starting biologics}, author = {Visuri, I and Dannenberg, Katharina and Salomon, Benita and Lundström, M. Ling and Bergemalm, Daniel and Eriksson, Carl and Lindqvist, Mårten and Keita, Å. V and Magnusson, M. K. and D'Amato, M. and Hjortswang, H. and Strid, H. and Söderholm, J. D. and Öhman, L. and Carlson, M. and Kruse, Robert and Hedin, C. R. H. and Repsilber, Dirk and Halfvarson, Jonas}, year = {2025}, journal = {Journal of Crohn's & Colitis}, volume = {19}, number = {Suppl. 1}, pages = {i1873--i1874}, doi = {10.1093/ecco-jcc/jjae190.1185}, url = {1940322}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background: Inter-individual differences in drug clearance are common in inflammatory bowel disease (IBD) patients treated with biologics. Associations between inflammatory markers, clinical features, and drug levels may indicate that the inflammatory immune response influences the pharmacokinetics of biologics. We assessed the impact of inflammatory and immunity-related proteins on drug levels in IBD.Methods: Serum samples from 144 IBD patients initiating biologics in a prospective multicentre cohort were analysed using AFIAS-3 (Boditech Med Inc. Korea). The primary outcome was drug levels after the end of induction treatment (post-induction), analysed as continuous variables or categorised into high or low groups based on the median. Correlations were assessed using the Pearson’s correlation coefficients with false discovery rate (FDR) adjustment. Predictive capacity of clinical and protein data was evaluated with regularised linear regression models. Analyses were stratified by treatment (infliximab, adalimumab, vedolizumab) and diagnosis (Crohn’s disease (CD), ulcerative colitis (UC)).Results: Patient demographics and clinical characteristics are provided in Table 1. Median (interquartile range, IQR) post-induction infliximab levels were 5.3 (2.2-9.5) μg/ml in patients with CD (n=34) and 3.8 (1.7-5.6) μg/ml in UC (n=33). The corresponding levels were 12.5 (7.0-16.1) μg/ml (n=36) and 8.8 (5.7-12.7) μg/ml (n=13) for adalimumab, 13.9 (6.4-24.4) μg/ml (n=19) and 17.7 (9.8-22.6) μg/ml (n=9) for vedolizumab. Principal component analyses revealed potential baseline protein profile differences between patients with high vs low post-induction levels for infliximab (p=0.09) and adalimumab (p=0.07) in CD, but no differences for vedolizumab (p=0.78) or UC. Individual protein analyses indicated that patients with higher drug levels post-induction seemed to display lower baseline estimates of inflammatory proteins compared to those with lower drug levels. However, statistical significance after correction for multiple comparisons was only observed for CDCP1 in adalimumab-treated CD patients (PFDR=0.04) (Figure 1). Additionally, baseline Flt31 (r=-0.57, PFDR=0.03) and Wisp1 (r=-0.61, PFDR=0.02) correlated with post-induction s-adali-mumab levels in CD, while Mcp3 (r=-0.89, PFDR=0.04) and Frgamma (r=-0.87, PFDR=0.05) correlated in UC. Integrating baseline protein data in prediction models for post-induction drug levels did not improve their accuracy compared to models based on only clinical and biochemical variables.Conclusion: Inflammatory protein levels may influence post-induction drug levels in IBD, particularly in adalimumab treated CD patients. This insight could aid in optimising personalised treatment.}, issn = {1873-9946} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jendlejohan_2025, title = {Cost-effectiveness of AID use in individuals with diabetes across different patient groups in Sweden, Norway, Denmark and Finland; 30-year simulation results}, author = {Jendle, Johan and Pimiä, E. and Syleouni, M. -E and Miron, A. Khan and Nørgaard, K.}, year = {2025}, journal = {Diabetologia}, volume = {68}, number = {Suppl. 1}, pages = {S444--S444}, url = {2039868}, language = {eng}, publisher = {Springer}, abstract = {Background and aims: Automated insulin delivery (AID) systems have revolutionized diabetes therapy: improving glucose levels while tremendously simplifying diabetes management for people living with diabetes. With AID uptake rapidly increasing, there is a need to assess the viability of widespread adoption for health care systems. This health economics study aims to provide a comprehensive analysis of the clinical and economic impact of AID across various patient groups in the Nordic region.Materials and methods: We evaluated the cost-effectiveness of AID versus MDI+CGM over a 30 years’ time horizon. IQVIA Core Diabetes Model v.10 was used to simulate different patient cohorts based on published literature and country-specific cost data. The different patient groups analyzed were: children and youth with type 1 diabetes (T1D), adults with T1D, and adults with type 2 diabetes (T2D). Baseline HbA1c with MDI+CGM was: 7.9% for T1D children and youth, 9.0% for adults with T1D, and 9.1% for adults with T2D. Based on the selected studies, the following AID-attributable HbA1c reductions were applied: 0.7%, 1.4% and 1.3% respectively.Results: Quality adjusted life years (QALY) gains were observed in all AID groups: 1.4 for children and youth with T1D, 1.5 for adults with T1D and 0.8 for adults with T2D. Reduced diabetes-related complications were observed in all groups; in T1D pediatrics 34% [SD: 1.9%], in T1D adults 48% [SD: 1.1%], in T2D adults 23% [SD:2.3%]. The incremental cost effectiveness ratio (ICER), which is used to assess cost-effectiveness, remained below all the country-specific willingness-to-pay (WTP) thresholds for all groups (Figure 1).Conclusion: The use of AID systems leads to both short- and long-term clinical benefits alongside with reduced economic impact. In the Nordic region, AID has been shown to be a cost-effective therapy across all analyzed patient groups. These findings highlight the importance of appropriate budget allocation for diabetes technologies, which in turn contribute to reduced healthcare resources utilization. Expanding access to AID systems in the Nordics could provide significant benefits for patients, healthcare systems, and society as a whole.}, issn = {0012-186X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tangxiaoyu_2025, title = {Cost-effectiveness of preventive COVID-19 interventions : a systematic review and network meta-analysis of comparative economic evaluation studies based on real-world data}, author = {Tang, Xiaoyu and Sun, Sun and Memedi, Mevludin and Hiyoshi, Ayako and Montgomery, Scott and Cao, Yang}, year = {2025}, journal = {Journal of Global Health}, volume = {15}, doi = {10.7189/jogh.15.04017}, url = {1939231}, language = {eng}, publisher = {Global Health Society}, abstract = {BACKGROUND: There is a knowledge gap regarding the effectiveness and utility of various preventive interventions during the COVID-19 pandemic. In this study, we aimed to evaluate the cost-effectiveness of various COVID-19 preventive interventions, including non-medical interventions (NMIs) and vaccination programs, using real-world data across different demographic and socioeconomic contexts worldwide.METHODS: We searched Medline, Cochrane Library, Embase, and Web of Science Core Collection from December 2019 to March 2024. We identified 75 studies which compared 34 COVID-19 preventive interventions. We conducted a network meta-analysis to assess the incremental net benefits (INB) of these interventions from both societal and health care system perspectives. We adjusted purchasing power parity (PPP) and standardised willingness to pay (WTP) to enhance the comparability of cost-effectiveness across different economic levels. We performed sensitivity and subgroup analyses to examine the robustness of the results.RESULTS: Movement restrictions and expanding testing emerged as the most cost-effective strategies from a societal perspective, with WTP-standardised INB values of USD 21 050 and USD 11 144. In contrast, combinations of NMIs with vaccination were less cost-effective, particularly in high-income regions. From a health care system perspective, vaccination plus distancing and test, trace, and isolate strategy were highly cost-effective, while masking requirements were less economically viable. The effectiveness of interventions varied significantly across different economic contexts, underlining the necessity for region-specific strategies.CONCLUSIONS: In this study, we highlight significant variations in the cost-effectiveness of COVID-19 preventive interventions. Tailoring strategies to specific regional economic and infrastructural conditions is crucial. Continuous evaluation and adaptation of these strategies are essential for effective management of ongoing and future public health threats.REGISTRATION: PROSPERO: CRD42023385169.}, issn = {2047-2978} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jendlejohan_2025_1, title = {COST-EFFECTIVENESS OF REAL-TIME CONTINUOUS GLUCOSE MONITORING SYSTEM VERSUS SELF-MONITORING OF BLOOD GLUCOSE IN PEOPLE WITH TYPE 2 DIABETES ON INSULIN THERAPY}, author = {Jendle, Johan and Ilham, Sabrina and Alshannaq, Hamza and Norman, Gregory and Lynch, Peter}, year = {2025}, journal = {Diabetes Technology & Therapeutics}, volume = {27}, number = {Suppl. 2}, pages = {E69--E70}, url = {2038352}, language = {eng}, publisher = {Mary Ann Liebert}, abstract = {Background and Aims: Real-time continuous glucose monitoring (RT-CGM) improves glycemic control and results in cost savings for individuals with Type 2 Diabetes on insulin therapy (T2D IT). We examined the cost-effectiveness of RT-CGM for people with T2D IT in Sweden.Methods: The analysis used IQVIA CORE Diabetes Model v10 over a 50-year time horizon from a Swedish payor perspective. Cohort characteristics and clinical effectiveness data were sourced from the Steno2Tech trial, demonstrating a 0.9% reduction in HbA1c and a 1.1 kg/m2 reduction in body mass index (BMI) in RT-CGM vs. SMBG users after 12-month of follow-up. HbA1c and BMI trajectories were based on the Swedish National Diabetes Registry. A utility benefit for avoidance of fingerstick (0.03) was applied to RT-CGM users. RT-CGM (Dexcom ONE+) and SMBG costs were based on local prices. Costs and outcomes were discounted at 3% rate. Sensitivity analyses were conducted.Results: RT-CGM was associated with an incremental quality-adjusted life year (QALY) of 0.458, incremental lifetime costs of 130,717 Swedish Krona (SEK), and an incremental cost-effectiveness ratio (ICER) of SEK 285,221 per QALY compared with SMBG, significantly below the willingness to pay threshold of SEK 500,000 in Sweden. Sensitivity analyses modeling HbA1c and BMI trajectories using UKPDS equations reduced the ICER by 45%, and RT-CGM became cost-saving under an upward HbA1c progression scenario. RT-CGM users experienced a relative reduction in cumulative incidence of ocular, renal, and neurological outcomes by 3.19%, 3.16%, and 2.76% respectively.Conclusions: Dexcom ONE+ is a cost-effective intervention for people with T2D IT in Sweden compared to SMBG.}, issn = {1520-9156} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jendlejohan_2025_2, title = {Cost-Utility of Real-Time Continuous Glucose Monitoring Versus Self-monitoring of Blood Glucose in People with Insulin-Treated Type 2 Diabetes in Sweden}, author = {Jendle, Johan and Ilham, Sabrina and Alshannaq, Hamza and Matuoka, Jessica Y. and Pollock, Richard F. and Ahmed, Waqas and Norman, Gregory J.}, year = {2025}, journal = {Diabetes Therapy}, volume = {16}, number = {12}, pages = {2311--2331}, doi = {10.1007/s13300-025-01811-x}, url = {2010735}, language = {eng}, publisher = {Springer Nature}, keywords = {continuous glucose monitoring; cost-utility; health economics; quality of life; self-monitoring of blood glucose; type 2 diabetes}, abstract = {INTRODUCTION: The aim of this study was to investigate the cost-utility of real-time continuous glucose monitoring (rt-CGM) versus self-monitoring of blood glucose (SMBG) in people with insulin-treated type 2 diabetes (T2D) in Sweden.METHODS: The CORE Diabetes Model (CDM v10) was used for the analysis. Clinical effectiveness data were obtained from the Steno2Tech trial, an investigator-initiated, 12-month, single center randomized controlled trial based in Denmark. Adverse event rates were sourced from a large-scale observational study based in the USA. Costs were obtained from Swedish and European studies and inflated to 2023 Swedish Krona (SEK). The analysis adopted the perspective of the Swedish payer, and a remaining lifetime horizon was used in the base case. A discount rate of 3% was applied to future costs and outcomes on an annual basis. A commonly cited willingness-to-pay (WTP) threshold of SEK 500,000 was used.RESULTS: rt-CGM led to a gain in mean incremental survival by 0.082 years (11.529 life years for rt-CGM versus 11.447 life years for SMBG). Total mean incremental costs were SEK 138,448 higher with rt-CGM compared with SMBG (SEK 1,151,049 for rt-CGM versus SEK 1,012,601 for SMBG). However, rt-CGM incurred fewer overall diabetes-related complication costs than SMBG over the remaining lifetime horizon. Rt-CGM also yielded a gain in mean incremental quality-adjusted life years (QALYs) of 0.632 (8.608 QALYs for rt-CGM versus 7.976 QALYs for SMBG). The mean incremental cost-utility ratio (ICUR) for rt-CGM was SEK 219,063 per QALY gained, which showed rt-CGM to be cost-effective when compared with the WTP threshold of SEK 500,000. When various indirect cost estimates were incorporated, rt-CGM was consistently more cost-effective than in the base case analysis.CONCLUSIONS: For individuals living in Sweden with T2D requiring insulin treatment, rt-CGM is a cost-effective management option relative to SMBG.}, issn = {1869-6953} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_tidermansterbergjennie_2025, title = {Cow choirs : Singing-with more-than-human herds}, author = {Tiderman-Österberg, Jennie}, year = {2025}, pages = {187--209}, doi = {10.4324/9781003390992-12}, url = {2029166}, language = {eng}, publisher = {Taylor and Francis}, abstract = {In times of mass extinctions and climate crisis, the question of human-animal-environment co-dependencies is an urgent matter. Eco- and ecocritical ethnomusicological research, which questions human uniqueness and self-proclaimed mastery by approaching music as a more-than-human affair, has proven to offer insights on this matter. By opening music to the more-than-human, music research could generate inclusive and ethical approaches to that which authoritative Western narratives have othered. This chapter partakes in that project by exploring how vocal herding music is constituted by the virtue of interspecies relations. It analyzes the processes of voice production, that is, how music-as-process is organized by the more-than-human, and how vital matter actively partakes in the creation of voice and song on a continuum when singing while herding cows and sheep. Using autoethnographic and affective methods, the chapter shows that the movements, rhythms, and voices of animals deeply affect how singing comes to be and how it transforms to become different than itself. Furthermore, it also demonstrates that vocal herding music is a rooted and situated activity where the relations between singer and landscape, such as inclination walking, obstruct voice and create differences regarding timbres, dynamics, and phrases of the song.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mortensenjoachimh_2025, title = {CPa9-HNE and PRO-C6 Biomarkers Reflect Fibrostenotic Strictures and Endoscopic Disease Activity in Crohn's Disease - IBSEN III Study}, author = {Mortensen, Joachim H. and Glad, Ida Frivold and Alexdóttir, Marta Sorokina and Tsapanou-Katranara, Thomai and Halfvarson, Jonas and Opheim, Randi and Lund, Charlotte and Aabrekk, Tone Bergene and Strande, Vibeke and Bengtson, May-Bente and Detlie, Trond Espen and Valeur, Jørgen and Bay-Jensen, Anne-Christine and Karsdal, Morten Asser and Hoivik, Marte L. and Kristensen, Vendel Ailin}, year = {2025}, journal = {American Journal of Gastroenterology}, volume = {120}, number = {Suppl. 12}, pages = {S39--S39}, doi = {10.14309/01.ajg.0001172984.42710.f2}, url = {2039999}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, abstract = {Background: In Crohn’s disease (CD), persistent neutrophil activation, including neutrophil extracellular traps (NETs), together with fibroblast activation, contributes to pathological tissuere modeling. This interplay promotes excessive collagen deposition, mucosal damage, and ultimately fibrostenotic strictures. We investigated 2 serum biomarkers with distinct biological origins: PRO-C6, reflecting type VI collagen formation and myofibroblast activity, and a novel calprotectin neo-epitope (CPa9-HNE), indicative of neutrophil activation and NETosis. Their associations with endoscopic disease activity and fibrostenotic complications were assessed in treatment-naïve CD patients from the prospective IBSEN-III inception cohort.Methods: Serum from 142 patients with newly diagnosed CD was analyzed at baseline and after one year of follow-up. Disease phenotype was classified according to the Montreal system (luminal, fibrostenotic, fistulizing). The biomarkers (PRO-C6, CPa9-HNE)) were assayed at both time points (baseline: luminal n 5 114, stricturing n 5 23, fistulizing n 5 5; year 1: luminal n 5 111, stricturing n 5 24, fistulizing n 5 7). Cross-sectional analyses were paired with the corresponding Montreal classification, and longitudinal changes were evaluated. Statistical analyses included one-way ANOVA with LSD post-hoc testing.Results: Among the 2 markers, CPa9-HNE showed a significant correlation with endoscopic severity (SES-CD; r 5 0.35, P 5 0.009). At baseline, both PRO-C6 (P , 0.001) and CPa9-HNE (P , 0.05) were elevated in patients with stricturing disease compared to those with luminal CD. PRO-C6 remained elevated after one year in the stricturing group (P , 0.01). Notably, 9 patients initially classified as luminal CD developed strictures within one year; their baseline PRO-C6 levels were significantly higher than in patients who did not progress.Conclusions: These findings support PRO-C6 as a promising serum biomarker for intestinal fibrosis in Crohn’s disease, as it was elevated both at diagnosis and during follow-up in patients with strictures, and was able to identify patients at risk of progression. Elevated CPa9-HNE in stricturing disease further points to neutrophil activation and NETosis as drivers of fibrogenesis. Together, these serum biomarkers highlight complementary inflammatory and fibrotic pathways and may provide clinically useful tools for monitoring fibrostenotic complications in Crohn’s disease.}, issn = {0002-9270} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_wintonpatrik_2025, title = {Credit and the Contractor State ín Prussia and Sweden, 1740-1815}, author = {Winton, Patrik}, year = {2025}, url = {1990643}, language = {eng}, abstract = {The state formation processes in Prussia and Sweden have often been described in the literature as driven by the military exploitation of foreign territories in combination with a relative efficient mobilization of limited domestic resources. Credit and capital have not been seen as important factors in these processes. It has been emphasized that Prussia did not have any long-term government debt, while Sweden in the eighteenth century was dependent on unstable systems of paper money to finance its wars. In my presentation, I will examine the role credit played in the systems of military procurement. By using the contractor state perspective, which focuses on the spending of states and the relationship between states and merchants, I can shed new light on how credit functioned during wartime in the two states.In Sweden, the government used special procurement commissions to centralize procurement. This arrangement required the close interaction with merchants and the financial support of institutions such as the Bank of the Estates. Merchants provided information, international contacts and short-term credit, while the state paid the merchants promptly upon the delivery of goods. The system would not have worked without the credit of the state.In Prussia, the government did not centralize procurement. Instead, it relied on ordinary taxation, war commissariats close to the theater of war and contributions from enemy territory. However, Prussia also required the assistance of merchants, and the contributions can be seen as a way to get indirect access to credit in places such as Breslau, Leipzig and Rostock since the merchants could not provide the goods to the Prussian army without the use of their credit. During the Napoleonic Wars, the Prussian system was forced to change in order to cope with the demand for goods that the French army put on the Prussian Crown after 1806. In order to deliver the vast quantities of goods, the Prussians had to develop ties with merchants in several locations, and it had to rely on credit since it was impossible to pay the suppliers with ordinary revenues. After the war, the debt was maintained and Prussia developed a system of long-term debt.In Sweden, the government opted not to centralize procurement during the Napoleonic Wars. Instead, it relied mostly on local war commissariats and merchants in Lübeck, Stralsund and Ostrobothnia. The role of credit was limited during the military campaigns, and stating in 1812, government debt was slowly liquidated. Thus, while Prussia developed into a fiscal-military state that depended on credit during the Napoleonic Wars, Sweden dismantled its fiscal-military state after 1815. } } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_bergjacob_2025_1, title = {Criminalisation of sanctions violation}, author = {Öberg, Jacob}, year = {2025}, pages = {173--176}, url = {2016209}, language = {eng}, publisher = {Edward Elgar Publishing}, keywords = {sanctions; international sanctions; eu sanctions; eu law; criminal law}, abstract = {This entry examines the criminalisation of sanctions violations, which can be defined as the process of establishing breaches of international sanctions as criminal offences under domestic law. One of the key ideas behind criminalisation in this field is to deter individuals and companies from violating the relevant international sanctioning regime. Nonetheless, states around the world adopt very divergent approaches in relation to the extent to which they criminalise breaches of restrictive measures, thus potentially undermining the overall effectiveness of the sanctioning regime. Since the Russian invasion of Ukraine, the European Union (EU) has adopted a very comprehensive sanctioning regime against Russia, including a directive that criminalises the violation of EU restrictive measures. If viewed in terms of its communicative dimension, the criminalisation of sanctions violations can be considered an effective tool in achieving the specific foreign policy objectives of states and international organisations.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_jonssonjessica_2025, title = {Criminalized Economies of War : Framing Grievable Lives in Southern Sudan}, author = {Jonsson, Jessica}, year = {2025}, url = {1993577}, language = {eng}, abstract = {Drawing on Judith Butler’s Frames of War and the concept of grievable lives, this paper examines the situation in Southern Sudan during the Second Civil War (1983-2005). Much of the South Sudan People’s Liberation Army’s funding for its armed resistance came from a criminalised economy that diverted humanitarian aid intended for the civilian population. In its most extreme form, this aid was stolen and resold to civilians at inflated prices. The civilians were framed, in the literal sense of the word. Similar patterns of aid exploitation were observed by the Revolutionary United Front in Sierra Leone and armed actors in Somalia, where humanitarian assistance was systematically redirected to sustain violence. These criminal economies formed an integral part of guerrilla governance.The new state of South Sudan, which emerged after five decades of violent resistance against the Government of Sudan in Khartoum, tops the corruption statistics, two-thirds of the population remains dependent on humanitarian aid, and the country is in a widespread political and economic crisis, exacerbated by the non-international armed conflict in the neighbouring country Sudan. From the perspective of the civilian population, there is a continuum of violence and harm, which first was framed as a necessity to liberate the country from oppression of the Arab government in the north. Later, it was reframed as a battle of power and recognition. These frames guide the interpretation of a situation, and the framing involves a “highly reflexive overlay of the visual field” (Butler, p. 9). The visualities include starvation, governance mismanagement, and exploitation.This paper explores how armed criminal economies shape access to humanitarian aid and how this determines whose suffering is seen and valued. It links grievances to guerrilla governance, revealing how war economies obscure or highlight lives deemed worthy of grief.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrnbergamelia_2025, title = {Critical Steps in Shotgun Metagenomics-Based Diagnosis of Bloodstream Infections Using Nanopore Sequencing}, author = {Björnberg, Amelia and Nestor, David and Peker, Nilay and Sinha, Bhanu and Couto, Natacha and Rossen, John and Sundqvist, Martin and Mölling, Paula}, year = {2025}, journal = {Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)}, volume = {133}, number = {1}, doi = {10.1111/apm.13511}, url = {1927510}, language = {eng}, publisher = {Munksgaard Forlag}, abstract = {Shotgun metagenomics offers a broad detection of pathogens for rapid blood stream infection of pathogens but struggles with often low numbers of pathogens combined with high levels of human background DNA in clinical samples. This study aimed to develop a shotgun metagenomics protocol using blood spiked with various bacteria and to assess bacterial DNA extraction efficiency with human DNA depletion. The Blood Pathogen Kit (Molzym) was used to extract DNA from EDTA-whole blood (WB) and plasma samples, using contrived blood specimens spiked with bacteria for shotgun metagenomics diagnostics via Oxford Nanopore sequencing and PCR-based library preparation. Results showed that bacterial reads were higher in WB than plasma. Differences for Staphylococcus aureus and Streptococcus pneumoniae were more pronounced compared to Escherichia coli. Plasma samples exhibited better method reproducibility, with more consistent droplet digital PCR results for human DNA. The study found that extraction was more efficient for Gram-positive bacteria than Gram-negative, suggesting that the human DNA depletion exerts a negative effect on Gram-negative bacteria. Overall, shotgun metagenomics needs further optimisation to improve bacterial DNA recovery and enhance pathogen detection sensitivity. This study highlights some critical steps in the methodology of shotgun metagenomic-based diagnosis of blood stream infections using Nanopore sequencing.}, issn = {0903-4641} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_hearnjeff_2025, title = {Critical Studies on Men and Masculinities : Enduring debates, institutionalization processes, divergences and challenges}, author = {Hearn, Jeff and Howson, Richard}, year = {2025}, pages = {255--271}, doi = {10.4324/9781003253068-20}, url = {1922475}, language = {eng}, publisher = {Routledge}, keywords = {men; masculinities; critical studies on men and masculinities}, abstract = {Men have historically dominated the written word, in academia, research, science, histories, literature, religion and many further arenas. Often, this domination has taken the shape of men writing about men, and for men, generally implicitly so. In contrast, this chapter focuses on critical studies on men and masculinities (CSMM) and the ‘absence presence’ of men and masculinities within systems and relations of gender power and domination, drawing on the full range of feminist and critical gender and sexuality scholarship. The chapter examines some of the enduring theoretical debates in and around CSMM, focusing on naming and deconstruction; power, domination, hegemony and risk-taking and socially problematic practices. The chapter continues by examining institutionalization processes: the making, reproduction and change in more durable academic activities, structures and interventions of CSMM. These include study groups, research groups, teaching, research and publication. The concluding discussion addresses current divergences and challenges in and around CSMM, in geopolitics; individual and group political and ethical positioning and empirical and theoretical content.}, file = {https://oru.diva-portal.org/smash/get/diva2:1922475/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_klglfranziska_2025, title = {Cross-border data flows and AI adoption : Agent-based model simulations}, author = {Klügl, Franziska and Kyvik Nordås, Hildegunn}, year = {2025}, journal = {Structural Change and Economic Dynamics}, volume = {75}, pages = {676--688}, doi = {10.1016/j.strueco.2025.10.009}, url = {2014448}, language = {eng}, publisher = {Elsevier}, keywords = {cross-border data flows; technology adoption; trade; agent based modeling}, abstract = {This paper develops a dynamic Agent Based Model to study the role of cross-border data flows for the joint uptake of artificial intelligence enabled software in manufacturing and engineering. The model features two technology-related business models: engineering as a face-to-face consultancy service, and engineering as a software licensing service. Engineering agents harvest data from their software clients in the home country and abroad and use the data for quality assurance and software updates. We compare scenarios along two dimensions: (i) harvesting data from own clients only versus from open data repositories, (ii) the strength of competition measured by the probability that a contract will be extended by another period. We find that restrictions on cross-border data flows slow down the speed of adoption considerably, particularly in small countries. The simulations generate an S-shaped technology uptake path for manufacturers and a U-shaped relationship between competition and technology uptake in engineering. Interestingly, cross-border data flows flatten the U.}, issn = {0954-349X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karimzadehsara_2025_2, title = {Cross-cultural perspectives on ethical consumption : A study of Swedish and Iranian citizens}, author = {Karimzadeh, Sara and Boström, Magnus}, year = {2025}, journal = {Journal of Consumer Culture}, volume = {25}, number = {1}, pages = {28--46}, doi = {10.1177/14695405241290920}, url = {1912345}, language = {eng}, publisher = {Sage Publications}, keywords = {ethical consumption; social practice theory; multilevel understanding; sweden; iran}, abstract = {Ethical consumption can take different forms, each with its own justifications and underlying rationales. While countries in north-western Europe have well-established mechanisms for promoting ethically labelled products, the situation is different in many other regions across the world. This paper examines ethical consumption in Sweden and Iran to identify the societal factors that influence the phenomenon. Employing social practice theory and a multilevel perspective, the empirical study explores the assumption that ethical consumption develops in an interplay between different levels and between different social actors, which can both challenge and rely on existing capacities. Data was generated from 34 semi-structured interviews with citizens in both countries. Expanding beyond micro-level factors, this study makes a dual contribution to the field of ethical consumption. First, it offers insights into the diverse ethical perceptions related to consumption across societies, broadening the understanding of various aspects of the phenomenon. Secondly, it sheds light on the role of societal regimes in the emergence and adoption of ethical consumption.}, issn = {1469-5405} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_elhajjvictorgabriel_2025, title = {Crossing the cervicothoracic junction in multilevel posterior fixations for degenerative cervical disease : a Swedish registry-based study}, author = {El-Hajj, Victor Gabriel and Bottini, Massimo and Nuriddinov, Bahridin and Staartjes, Victor E. and Edström, Erik and Elmi-Terander, Adrian}, year = {2025}, journal = {European spine journal}, doi = {10.1007/s00586-025-09521-5}, url = {2010460}, language = {eng}, publisher = {Springer}, keywords = {ctj; construct; crossing the cervicothoracic junction; multilevel fixation; posterior fixation}, abstract = {PURPOSE: The decision to cross the cervicothoracic junction (CTJ) during multilevel posterior cervical fusion remains controversial. While constructs extending into the thoracic spine may enhance stability, they may also increase surgical complexity. The clinical relevance of these differences, particularly regarding patient-reported outcomes (PROMs), is still unclear. We hence aimed to determine whether extending fusion across the CTJ impacts PROMs and perioperative complication rates in a nationwide cohort.METHODS: This retrospective cohort study used prospectively collected data from the Swedish Spine Registry (Swespine). Adult patients who underwent multilevel posterior cervical fusion were divided into two groups: those ending at C7 and those extending beyond the CTJ. Baseline characteristics, surgical details, complication rates, and PROMs at 1- and 5-years were compared.RESULTS: Baseline characteristics were similar between groups (p ≥ 0.5). Perioperative complication and reoperation rates did not differ significantly between groups (p ≥ 0.5). Similarly, at both one- and five-years of follow-up, PROMs, including pain scores, disability indices, and satisfaction, were comparable (p ≥ 0.5). However, a significant difference was observed in terms of fine motor recovery, with patients whose constructs crossed the CTJ demonstrating a greater degree of improvement (p = 0.009).CONCLUSIONS: Crossing the CTJ in multilevel posterior cervical fusion does not significantly affect complication rates, reoperations, or most PROMs at one and five years. Surgical decisions should prioritize anatomical and clinical factors, rather than expected differences in PROMs.}, issn = {0940-6719} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lixin_2025, title = {Cross-Sectional and Longitudinal Associations Between Olfaction and White-Matter Integrity Across the Lifespan}, author = {Li, Xin and Cedres, Nira and Olofsson, Jonas and Persson, Jonas}, year = {2025}, journal = {Human Brain Mapping}, volume = {46}, number = {14}, doi = {10.1002/hbm.70375}, url = {2005450}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {dti; aging; longitudinal; olfaction; white‐matter}, abstract = {The loss of smell is common in older age, reducing quality of life and often precedes the onset of cognitive decline and dementia. While age-related olfactory loss has been linked to cortical thinning and volume reductions in key olfactory areas, associations between white-matter (WM) integrity and olfaction are poorly understood. Here, we studied individuals aged 25-85 years from a population-based cohort study with diffusion weighted imaging, together with self-reported olfactory impairment, odor identification and odor threshold measures at baseline (N = 248) and follow-up 5 years later (N = 192). Performance on the odor identification and threshold tests were lower in older adults and declined longitudinally. Older individuals also reported more olfaction complaints, and such complaints increased over time. Results from general linear models showed no cross-sectional associations between WM integrity and olfaction. However, results from non-competitive random forest models identified several tracts as significant contributors to odor identification and subjective olfactory impairment, including the fornix, cingulum and uncinate fasciculus. Moreover, longitudinal analyses showed that olfactory threshold decline was associated with decline in WM integrity in the body of corpus callosum. Taken together, the results support a link between white-matter integrity and olfaction and provide initial evidence for its interplay with age.}, issn = {1065-9471} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_kumarnaman_2025, title = {CrowdSurfer : Sampling Optimization Augmented with Vector-Quantized Variational AutoEncoder for Dense Crowd Navigation}, author = {Kumar, Naman and Singha, Antareep and Nanwani, Laksh and Potdar, Dhruv and Tarun, R. and Rastgar, Fatemeh and Idoko, Simon and Singh, Arun Kumar and Krishna, K. Madhava}, year = {2025}, pages = {16854--16860}, doi = {10.1109/ICRA55743.2025.11128132}, url = {2029025}, language = {eng}, publisher = {IEEE}, abstract = {Navigation amongst densely packed crowds remains a challenge for mobile robots. The complexity increases further if the environment layout changes, making the prior computed global plan infeasible. In this paper, we show that it is possible to dramatically enhance crowd navigation by just improving the local planner. Our approach combines generative modelling with inference-time optimization to generate sophisticated long-horizon local plans at interactive rates. More specifically, we train a Vector Quantized Variational AutoEncoder to learn a prior over the expert trajectory distribution conditioned on the perception input. At run-time, this is used as an initialization for a sampling-based optimizer for further refinement. Our approach does not require any sophisticated prediction of dynamic obstacles and yet provides state-of-the-art performance. In particular, we compare against the recent DRL-VO approach [2] and show a 40% improvement in success rate and a 6% improvement in travel time.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_demydyukganna_2025_3, title = {Cruise Control : Steering Through the Waves of Customer Satisfaction Across Cruise Market Segments}, author = {Demydyuk, Ganna and Carlbäck, Mats}, year = {2025}, journal = {Journal of Gastronomy and Tourism}, volume = {8}, number = {3}, pages = {153--169}, doi = {10.3727/216929824X17207924097162}, url = {1894625}, language = {eng}, publisher = {Cognizant Communication Corporation}, keywords = {cruise industry; ea experience accounting; online reviews; customer satisfaction; value for money; cruise dining; food and dining onboard; cruise market classification}, abstract = {This study investigates the intricate relationships between overall cruise rating and various experience attributes by leveraging a comprehensive dataset of consumer reviews from two major online platforms. The analysis revealed that the core elements of hospitality, particularly dining and service, are critical for overall cruise satisfaction, perceived value, and ship quality perceptions. A major finding of this study is the critical role of perceived value for money in shaping the satisfaction narratives expressed by cruise patrons in online reviews in all market segments. The originality of this study lies in its examination of various market segments and review samples, which illuminate the complex and multidimensional aspects of customer satisfaction. The results indicate that hospitality strategies should vary significantly across segments, further emphasising the need for a nuanced approach because of the varied expectations across these markets. Furthermore, the study reveals a pattern suggesting that cost-cutting efforts, when involving food costs, result in lower satisfaction levels in dining and multiple categories, ultimately opposing potential savings. This insight emphasises the need for cruise lines to balance cost-cutting measures carefully while maintaining high-quality dining experiences to enhance overall customer satisfaction. These findings underscore the importance of utilising diverse review metrics to develop a multidimensional framework for customer-centric performance management across all hospitality sectors. }, issn = {2169-2971} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_reiserdaniel_2025, title = {CT Motion-Analysis of Implant Loosening in Total Wrist Arthroplasty : A Pilot Study}, author = {Reiser, Daniel and Kakar, Sanj and Sandberg, Olof and Wretenberg, Per and Sagerfors, Marcus}, year = {2025}, journal = {Journal of wrist surgery}, doi = {10.1055/a-2528-0045}, url = {1944660}, language = {eng}, publisher = {Thieme Medical Publishers}, keywords = {ct motion-analysis; implant loosening; total wrist arthroplasty}, abstract = {Introduction: Total wrist arthroplasty (TWA) is a motion-preserving treatment option for wrist arthritis. High-precision measurement methods for implant migration such as computed tomography motion-analysis (CTMA) can potentially detect poor implant fixation. The aim of this pilot study was to assess CTMA as a complementary method to diagnose aseptic loosening of TWA.Materials and Methods: Three patients with a TWA and wrist pain during activity underwent induced displacement CT (CTMA) with alternated provocations as a complement to plain radiographs.Results: Two of the three patients had displacement of the carpal component on CTMA. The radial component was stable in all cases. The tool was adapted to clinical routine use.Conclusions: CT motion-analysis could be a valuable adjunct to plain radiographs in assessing component loosening in TWA.}, issn = {2163-3916} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_everhovsah_2025_1, title = {Cumulative incidence and prevalence of perianal diseases in patients with inflammatory bowel disease and in the population : a nationwide Swedish study}, author = {Everhov, Åsa H. and Eberhardson, Michael and Söderling, Jonas and Nordenvall, Caroline and Halfvarson, Jonas and Ludvigsson, Jonas F. and Olén, Ola and Myrelid, Pär and Strid, Hans and Hjortswang, Henrik and Olsson, Malin and Bengtsson, Jonas L. and Andersson, Marie A. and Karling, Pontus and Rejler, Martin and Jäghult, Susanna and Fagerberg, Ulrika L. and Mårild, Karl and Hreinsson, Johann and Hedin, Charlotte}, year = {2025}, journal = {Scandinavian Journal of Gastroenterology}, volume = {60}, number = {4}, pages = {349--354}, doi = {10.1080/00365521.2025.2476669}, url = {1946351}, language = {eng}, publisher = {Taylor & Francis}, keywords = {crohn’s disease; ibd unclassified; perianal fistula; incidence; inflammatory bowel disease; population-based; prevalence; ulcerative colitis}, abstract = {Background: Perianal diseases are more common in patients with Crohn's disease (CD) than in the general population, but data are scarce in other inflammatory bowel disease (IBD) subtypes.Method: Using data from the Swedish National Patient Register (NPR) and SWIBREG, the national quality register for IBD, we estimated the cumulative incidence of perianal fistula/abscess and perianal diseases (fistula, abscess, stenosis, fissure or procedure code for perianal surgery) in relation to diagnosis, and the prevalence in 2023, in individuals with CD, ulcerative colitis (UC) and IBD-unclassified (IBD-U), and in a matched (age, sex, calendar year and region of residence) IBD-free cohort from the general population.Results: We identified 38,364 patients with incident IBD 2007-2017, and 98,229 patients with prevalent IBD as of 31 December 2022. The cumulative incidence of fistula/abscess was 6.7% at diagnosis, 8.3% at 1 year and 10.4% at 5 years in CD. The corresponding percentages in UC were 0.9%, 1.3% and 2.1%, and in IBD-U 2.4%, 3.1% and 4.5%, respectively. In 2023, 12.8%, 3.1% and 4.1% of patients with prevalent CD, UC and IBD-U had a history of fistula/abscess, compared to 0.8% in the general population. The corresponding numbers for perianal diseases were 19.7%, 7.4%, 8.6% and 2.2%.Conclusions: The cumulative incidence and prevalence of perianal diseases in Swedish patients with CD was in parity with reports from other countries, and in patients with UC and IBD-U, it was 3-4 times higher than in the population.}, issn = {0036-5521} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_forsstenmaximilianpeter_2025, title = {Current clinical characteristics and Management of Pediatric Traumatic Atlantoaxial Rotatory Subluxation : An American College of Surgeons Trauma Quality Improvement Program analysis}, author = {Forssten, Maximilian Peter and Ioannidis, Ioannis and Forssten, Sebastian Peter and Mohammad Ismail, Ahmad and Cao, Yang and Sarani, Babak and Mohseni, Shahin}, year = {2025}, journal = {Journal of Trauma and Acute Care Surgery}, volume = {94}, number = {4}, pages = {580--587}, doi = {10.1097/TA.0000000000004619}, url = {1968022}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, keywords = {atlantoaxial rotatory subluxation; cervical spine trauma; current management; outcomes; pediatric trauma}, abstract = {BACKGROUND: Atlantoaxial rotatory subluxation (AARS) is an important differential diagnosis in pediatric patients presenting with torticollis, which is caused by the subluxation of the C1 vertebra relative to the C2 vertebra. Because of the uncommon nature of this condition, there is a paucity in sufficiently sized studies describing AARS. The aim of the current investigation was therefore to characterize current clinical characteristics and management of AARS.METHODS: The American College of Surgeons Trauma Quality Improvement Program database from 2016 to 2021 was queried for pediatric (17 years old or younger) patients who were diagnosed with AARS following blunt trauma. Patients were grouped by age in order to describe and compare demographics, clinical characteristics, and in-hospital outcomes. A subgroup analysis was also performed on patients with isolated AARS, defined as AARS without the presence of a cervical fracture and an Abbreviated Injury Scale score of ≤1 in all regions besides the spine.RESULTS: A total of 469 cases of AARS were identified, 211 (45.0%) were isolated AARS. Of these patients, 56.3% of AARS patients and 64.5% of isolated AARS patients were 8 years old or younger. Atlantoaxial rotatory subluxation in adolescents was due to a motor vehicle collision in 60.0% of cases, while 52.5% of infants/toddlers were injured in falls. Of all patients with AARS, 87.4% were managed conservatively, with or without a brace/other immobilizing device, while surgery was only indicated in 9.3% of patients. In cases of isolated AARS, conservative treatment was even more prevalent, with 92.4% of patients managed conservatively and only 4.7% requiring surgical intervention.CONCLUSION: Atlantoaxial rotatory subluxation is most common in children 8 years old and younger, with the majority of cases resulting from falls or motor vehicle accidents. In the Trauma Quality Improvement Program database, most cases were able to be managed conservatively without the need for surgical intervention.LEVEL OF EVIDENCE: Care Management; Level III.}, issn = {2163-0755} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_yansylvia_2025, title = {Current practices and variability in dynamic sentinel node biopsy for penile cancer : A survey of European Referral Centers}, author = {Yan, Sylvia and Longoni, Mattia and Basile, Giuseppe and Fankhauser, Christian D. and Nardo, Nicola Di and Sanchez, Raul and Gaya, Jose Maria and Elst, Laura and de Vries, Hielke M. and Verdijk, Rick and Ayres, Benjamin and Watkin, Nicholas and Glombik, Dominik and Breda, Alberto and Albersen, Maarten and Salonia, Andrea and Brouwer, Oscar and Bandini, Marco}, year = {2025}, journal = {Urologic Oncology}, volume = {43}, number = {11}, pages = {665.e11--665.e16}, doi = {10.1016/j.urolonc.2025.06.022}, url = {1990453}, language = {eng}, publisher = {Elsevier}, abstract = {BACKGROUND: Dynamic sentinel node biopsy (DSNB) is the currently preferred staging method of high-risk penile cancer (PeCa) patients with cN0 disease. Recently, there have been advancements in the surgical approach and techniques. This study aims to compare the contemporary DSNB practice and techniques amongst European referral centers.MATERIALS AND METHODS: An online survey was sent to members of the EAU YAU Penile and Testis Cancer working group. These questions delved into various facets of DSNB, encompassing imaging techniques, tracers, surgical approaches, and postoperative patient care. Participating centers were also required to provide video-recorded DSNB procedures in a standardized manner for a comparative analysis of technical nuances.RESULTS: Responses were received from twelve Urologists from nine European centers. Overall, 83% and 42% of surgeons performed >10 and >50 DSNB procedures per year, respectively. There is a broad consensus on the technique and site of tracer injections. Conversely, 50% of centers use lymphoscintigraphy, 17% use SPECT/CT, while 33% utilize both imaging modalities. The predominant choice of dye is Patent V/blue, but 25% of centers use Indocyanine Green (ICG). Notable variability exists in surgical incision sites and lymphatic ligation techniques. The consensus is leaning towards not leaving a wound drain. Overall, 83% of centers adopt antibiotic surgical prophylaxis, with 83% discontinuing it postoperatively. A quarter of centers would advocate for patients to be discharged with thromboprophylaxis, either using low molecular weight heparin or thromboembolic deterrent stockings. On average, the postoperative length of stay in hospital is 1 day.CONCLUSIONS: Variation exists in procedural aspects and postoperative management among centers performing DSNB for PeCa. Newer technologies like fluorescence imaging and SPECT/CT are used in some European centers, but high-quality evidence is sparse, highlighting the need for extensive multicenter research into surgical outcomes and emerging technologies.}, issn = {1078-1439} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bolanakimyrto_2025, title = {Current sepsis management practices in European emergency departments : the ISG-emergency department European Survey}, author = {Bolanaki, Myrto and Kurland, Lisa and Brabrand, Mikkel and Daniels, Ron and Govender, Kiren and Hanses, Frank and Innocenti, Francesca and Lassen, Annmarie and Martin-Loeches, Ignacio and Möckel, Martin}, year = {2025}, journal = {European journal of emergency medicine}, volume = {32}, number = {5}, pages = {368--376}, doi = {10.1097/MEJ.0000000000001255}, url = {1990381}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, keywords = {1-h bundle; europe; emergency department; sepsis management}, abstract = {BACKGROUND: Emergency departments (EDs) are often the first point of contact for patients with sepsis, and therefore play a critical role in early recognition and treatment. However, the extent to which sepsis guidelines are implemented across EDs in Europe remains unclear, and variability in adherence may impact patient outcomes. OBJECTIVE: This study aimed to assess current sepsis management practices in European EDs, evaluate adherence to international guidelines, and identify key challenges limiting effective implementation.METHODS AND DESIGN: A structured survey was developed by sepsis experts from the European Society for Emergency Medicine (EUSEM). The questionnaire included both quantitative and open-ended items and underwent iterative refinement through pilot testing to ensure clarity and relevance.SETTINGS AND PARTICIPANTS: The survey was distributed to EUSEM members and national emergency medicine societies across Europe. Respondents included medical directors or designated sepsis specialists, with only one response requested per ED. RESULTS: A total of 402 EDs from 28 European countries participated in the survey. While most EDs (72.5%) reported having a sepsis protocol in place, less than half implemented regular monitoring or structured training measures. The 1-h sepsis bundle was described as moderately to highly challenging to implement by the majority of the respondents; just over half (55%) reported completing all its elements within 1 h of ED presentation. Key barriers included high patient volumes, insufficient staffing, and lack of standardized sepsis definitions, leading to delays in recognition and treatment. The results also highlighted concerns regarding increased broad-spectrum antibiotic use following the implementation of the 1-h bundle, emphasizing the need for a balanced approach that considers antimicrobial stewardship.CONCLUSION: This survey establishes a benchmark for understanding sepsis management practices in European EDs, identifying substantial variations and challenges. Areas for improvement include enhanced training to follow protocols, improved monitoring systems that measure protocol adherence, and alignment with evidence-based guidelines.}, issn = {0969-9546} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_qandeelmais_2025, title = {Cyber Surveillance and Data Violence in Palestine : Protection, Practice, and Legality}, author = {Qandeel, Mais}, year = {2025}, url = {1963809}, language = {eng}, abstract = {The use of technologies in situations of armed conflicts and belligerent occupation continues to lead to social and legal instabilities and aggravated violations. This panel highlights the issues pertaining to the status of Palestinians under Israeli AI-enhanced surveillance and their effects on fundamental rights. In doing so, this session will discuss the use of AI-enhanced systems to track Palestinians, systematizing massive surveillance and automating harsh restrictions to their rights and freedoms as part of a structural conduct of oppression. The session also discusses the role of social media platforms in facilitating digital control leading to authoritarian and genocidal surveillant assemblage, destruction of cyber infrastructure and data violence. This session, finally, explores the legality of such conduct under the applicable rules and norms of international law.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_balkmardag_2025_1, title = {Cycling Motilities : Conditions, Weights and Reliefs for Cycling in Disadvantaged Neighbourhoods in Sweden}, author = {Balkmar, Dag and Henriksson, Malin and Joelsson, Tanja}, year = {2025}, journal = {Active Travel Studies}, volume = {5}, number = {1}, pages = {1--16}, doi = {10.16997/ats.1590}, url = {1933531}, language = {eng}, publisher = {University of Westminster Press (UWP)}, keywords = {families; cycling motility; disadvantaged neighbourhoods; cycling policy; inclusive cycling in sweden}, abstract = {In current Swedish planning and policy discourse, cycling is seen as an efficient way to commute in urban environments and a key component in advancing more sustainable transport. In Sweden, cycling is more prevalent among the more affluent population, but there is (with some exceptions) little knowledge on cycling in low-income areas. Given that well-developed cycling infrastructure is available and that bicycling is a comparably low-cost transport mode, higher rates of cycling in disadvantaged neighbourhoods could be expected. For policies that increase inclusive cycling to be implemented, there is a need to understand what makes cycling achievable for diverse groups. Based on the everyday cycling experiences of 31 families living in socially disadvantaged and ethnically diverse neighbourhoods in Sweden, this paper provides qualitative accounts of cycling, knowledge that can inform policy. Key concepts from urban sociology are used to analyse a person’s conditions for cycling. Our findings suggest that while cycling could be considered a practical, social, and flexible mode of transport, especially for younger people, only a few adults in our sample cycled. The results reflect an ambivalence toward cycling as part of everyday mobility. Cycling was perceived as something “typically Swedish”, a norm conditioned by age, gender, and body related weights and reliefs and hard to combine with everyday care- and work responsibilities. The gap between preferred and used mode implies an untapped cycling potential, a finding that suggests that pro cycling policies need to pay increased attention to broader social justice perspectives to support cycling (also) in disadvantaged neighbourhoods.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssonmagnus_2025, title = {DAC7 Rules for Digital Platforms Sweden : Comparing EU Member States Implementation}, author = {Kristoffersson, Magnus and Kristoffersson, Eleonor}, year = {2025}, pages = {343--353}, url = {2021950}, language = {eng}, publisher = {Wolters Kluwer}, keywords = {dac 7; digital; platform; economy} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ribeirojuniormarceloaugustofontenelle_2025, title = {Damage control resuscitation : how it's done and where we can improve. A view of the Brazilian reality according to trauma professionals}, author = {Ribeiro Junior, Marcelo Augusto Fontenelle and Pacheco, Leticia Stefani and Duchesne, Juan Carlos and Parreira, Jose Gustavo and Mohseni, Shahin}, year = {2025}, journal = {Revista do Colégio Brasileiro de Cirurgiões}, volume = {51}, doi = {10.1590/0100-6991e-20243785-en}, url = {1928110}, language = {eng}, publisher = {Colegio Brasileiro de Cirurgioes}, abstract = {INTRODUCTION: Hemorrhage is the leading cause of preventable deaths in trauma patients, resulting in 1.5 million deaths annually worldwide. Traditional trauma assessment follows the ABC (airway, breathing, circulation) sequence; evidence suggests the CAB (circulation, airway, breathing) approach to maintain perfusion and prevent hypotension. Damage Control Resuscitation (DCR), derived from military protocols, focuses on early hemorrhage control and volume replacement to combat the "diamond of death" (hypothermia, hypocalcemia, acidosis, coagulopathy). This study evaluates the implementation of DCR protocols in Brazilian trauma centers, hypothesizing sub-optimal resuscitation due to high costs of necessary materials and equipment.METHODS: In 2024, an electronic survey was conducted among Brazilian Trauma Society members to assess DCR practices. The survey, completed by 121 participants, included demographic data and expertise in DCR.RESULTS: All 27 Brazilian states were represented in the study. Of the respondents, 47.9% reported the availability of Massive Transfusion Protocol (MTP) at their hospitals, and only 18.2% utilized whole blood. Permissive hypotension was practiced by 84.3%, except in traumatic brain injury cases. The use of tranexamic acid was high (96.7%), but TEG/ROTEM was used by only 5%. For hemorrhage control, tourniquets and resuscitative thoracotomy were commonly available, but REBOA was rarely accessible (0.8%).CONCLUSION: Among the centers represented herein, the results highlight several inconsistencies in DCR and MTP implementation across Brazilian trauma centers, primarily due to resource constraints. The findings suggest a need for improved infrastructure and adherence to updated protocols to enhance trauma care and patient outcomes.}, issn = {0100-6991} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_toumazahi_2025, title = {DAPIROLIZUMAB PEGOL DEMONSTRATED IMPROVEMENT IN QUALITY OF LIFE OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS : LUPUSQOL RESULTS FROM A PHASE 3 TRIAL}, author = {Touma, Zahi and Aranow, Cynthia and Parodis, Ioannis and Ramsey-Goldman, Rosalind and Schneider, Matthias and De La Loge, Christine and Jimenez, Teri and Nejati, Mina and Arnaud, Laurent}, year = {2025}, journal = {Journal of Rheumatology}, volume = {52}, number = {Suppl. 1}, pages = {11--12}, doi = {10.3899/jrheum.2025-0390.O011}, url = {2014511}, language = {eng}, publisher = {The Journal of Rheumatology}, issn = {0315-162X} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_straccaelena_2025, title = {DARKO-Nav : Hierarchical Risk and Context-Aware Robot Navigation in Complex Intralogistic Environments}, author = {Stracca, Elena and Rudenko, Andrey and Palmieri, Luigi and Salaris, Paolo and Castri, Luca and Mazzi, Nicolò and Rakcevic, Vasilije and Vaskevicius, Narunas and Linder, Timm and Bellotto, Nicola and Schreiter, Tim and Zhu, Yufei and Castellano-Quero, Manuel and Napolitano, Olga and Stefanini, Elisa and Heuer, Lukas and Magnusson, Martin and Swikir, Abdalla and Lilienthal, Achim J.}, year = {2025}, volume = {36}, pages = {155--161}, doi = {10.1007/978-3-031-89471-8_24}, url = {1996618}, language = {eng}, publisher = {Springer}, keywords = {navigation in dynamic environments; risk-aware path planning; predictive collision avoidance; intralogistics}, abstract = {We propose a flexible hierarchical navigation stack for a mobile robot in complex dynamic environments. Addressing the growing need for reliable navigation in real-world scenarios, where dynamic agents and environmental uncertainties pose significant challenges, our solution decomposes this complexity into task planning, navigation, control, and safe velocity components. In contrast to the prior art, our system at every level incorporates diverse contextual information about the environment, anticipates navigation risks and proactively avoids collisions with dynamic agents.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_3, title = {Dating in the Age of the Algorithm}, author = {Johansson Wilén, Evelina and Wemrell, Maria and Gunnarsson, Lena}, year = {2025}, journal = {Jacobin}, url = {2023559}, language = {eng}, publisher = {Jacobin Press}, issn = {2470-6930} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_grintkeith_2025, title = {David L. Collinson}, author = {Grint, Keith and Hearn, Jeff}, year = {2025}, pages = {83--85}, doi = {10.4337/9781803922065.ch24}, url = {1938768}, language = {eng}, publisher = {Edward Elgar Publishing}, keywords = {leadership; gender; organisations management; masculinities; men}, abstract = {David L. Collinson is a UK-based scholar of gender, organizations and management, with a special interest in leadership. Collinson can rightly claim to be amongst a small number of top-flight European scholars in his field. His range of work on critical approaches to leadership, management and organization is vast and variegated, with primary interests in: leadership and followership dialectics; power, identities and insecurities; gender, men and masculinities; conformity, dramaturgy and resistance; humour in organizations; and positivity and Prozac leadership. In particular, he has focused much of his academic work on two related subject areas, leadership, and gender, men and masculinities, thus bridging Critical Leadership Studies (CLS) and Critical Studies on Men and Masculinities (CSMM). }, file = {https://oru.diva-portal.org/smash/get/diva2:1938768/FULLTEXT02.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kumargulshan_2025, title = {DAWS : A Comprehensive Solution Against De-Anonymization Attacks in Blockchains}, author = {Kumar, Gulshan and Saha, Rahul and Conti, Mauro and Kim, Tai-Hoon}, year = {2025}, journal = {IEEE Transactions on Network and Service Management}, volume = {22}, number = {5}, pages = {4747--4761}, doi = {10.1109/TNSM.2025.3588273}, url = {2007789}, language = {eng}, publisher = {IEEE}, keywords = {blockchains; privacy; peer-to-peer computing; security; ip networks; bitcoin; virtual private networks; encryption; cryptography; data privacy; blockchain; attack; anonymity}, abstract = {De-anonymization attacks in blockchains are significant concerns as they compromise the privacy of users on a public ledger. Such attacks, in the form of network analysis and transaction patterns, aim to link a blockchain address to the identity of its owner, potentially revealing sensitive information. Though researchers introduce various solutions using Tor, VPN, and i2P to protect against de-anonymization in blockchains, they have certain limitations: i) non-verification of the private transactions, ii) reveal of the transaction graph, and iii) requirement of a trusted setup that is itself vulnerable to the adversary. All these lead to the revocation of de-anonymization problems. In this paper, we show a novel privacy assurance framework for blockchains. The proposed framework is called De-Anonymization Withstanding Solution (DAWS). DAWS is the first privacy-preserved blockchain framework against de-anonymization attacks. DAWS uses privacy-classifying smart contract execution and a novel consensus called Proof-of-Privacy (PoPri). A set of experiments is executed on PoPri as well as DAWS. The blockchain transactions are modified by including user-defined privacy labels. DAWS can handle attacker advantage >= 0.008 with a privacy breach probability <0.01% under our threat model. Besides, an improvement in the throughput of DAWS is noticed as compared to Ethereum (almost 80 times) with the Hyperledger configuration for consensus. The gas consumption improvement is 20%. All the listed features enhance the appeal of the proposed DAWS as a robust privacy-preserving solution against blockchain de-anonymization attacks.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_umairmuhammad_2025, title = {Decentralized EEG-based detection of major depressive disorder via transformer architectures and split learning}, author = {Umair, Muhammad and Ahmad, Jawad and Alasbali, Nada and Saidani, Oumaima and Hanif, Muhammad and Khattak, Aizaz Ahmad and Khan, Muhammad Shahbaz}, year = {2025}, journal = {Frontiers in Computational Neuroscience}, volume = {19}, doi = {10.3389/fncom.2025.1569828}, url = {1956079}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {eeg; autoencoder; major depressive disorder; neurological behavior; smart diagnostic; split learning; transformers}, abstract = {INTRODUCTION: Major Depressive Disorder (MDD) remains a critical mental health concern, necessitating accurate detection. Traditional approaches to diagnosing MDD often rely on manual Electroencephalography (EEG) analysis to identify potential disorders. However, the inherent complexity of EEG signals along with the human error in interpreting these readings requires the need for more reliable, automated methods of detection.METHODS: This study utilizes EEG signals to classify MDD and healthy individuals through a combination of machine learning, deep learning, and split learning approaches. State of the art machine learning models i.e., Random Forest, Support Vector Machine, and Gradient Boosting are utilized, while deep learning models such as Transformers and Autoencoders are selected for their robust feature-extraction capabilities. Traditional methods for training machine learning and deep learning models raises data privacy concerns and require significant computational resources. To address these issues, the study applies a split learning framework. In this framework, an ensemble learning technique has been utilized that combines the best performing machine and deep learning models.RESULTS: Results demonstrate a commendable classification performance with certain ensemble methods, and a Transformer-Random Forest combination achieved 99% accuracy. In addition, to address data-sharing constraints, a split learning framework is implemented across three clients, yielding high accuracy (over 95%) while preserving privacy. The best client recorded 96.23% accuracy, underscoring the robustness of combining Transformers with Random Forest under resource-constrained conditions.DISCUSSION: These findings demonstrate that distributed deep learning pipelines can deliver precise MDD detection from EEG data without compromising data security. Proposed framework keeps data on local nodes and only exchanges intermediate representations. This approach meets institutional privacy requirements while providing robust classification outcomes.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alijagicandi_2025_1, title = {Deciphering the phenotypic, inflammatory, and endocrine disrupting impacts of e-waste plastic-associated chemicals}, author = {Alijagic, Andi and Södergren Seilitz, Fredric and Bredberg, Anna and Hakonen, Aron and Larsson, Maria and Selin, Erica and Sjöberg, Viktor and Kotlyar, Oleksandr and Scherbak, Nikolai and Repsilber, Dirk and Kärrman, Anna and Wang, Thanh and Särndahl, Eva and Engwall, Magnus}, year = {2025}, journal = {Environmental Research}, volume = {269}, doi = {10.1016/j.envres.2025.120929}, url = {1930947}, language = {eng}, publisher = {Elsevier}, keywords = {waste from electrical and electronic equipment (weee); plastic additives; persistent organic pollutants; suspect chemical screening; cell painting; oxidative stress}, abstract = {As the volume of plastic waste from electrical and electronic equipment (WEEE) continues to rise, a significant portion is disposed of in the environment, with only a small fraction being recycled. Both disposal and recycling pose unknown health risks that require immediate attention. Existing knowledge of WEEE plastic toxicity is limited and mostly relies on epidemiological data and association studies, with few insights into the underlying toxicity mechanisms. Therefore, this study aimed to perform comprehensive chemical screening and mechanistic toxicological assessment of WEEE plastic-associated chemicals. Chemical analysis, utilizing suspect screening based on high-resolution mass spectrometry, along with quantitative target chemical analysis, unveiled numerous hazardous compounds including polyaromatic compounds, organophosphate flame retardants, phthalates, benzotriazoles, etc. Toxicity endpoints included perturbation of morphological phenotypes using the Cell Painting approach, inflammatory response, oxidative stress, and endocrine disruption. Results demonstrated that WEEE plastic chemicals altered the phenotypes of the cytoskeleton, endoplasmic reticulum, and mitochondria in a dose-dependent manner. In addition, WEEE chemicals induced inflammatory responses in resting macrophages and altered inflammatory responses in lipopolysaccharide-primed macrophages. Furthermore, WEEE chemicals activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, indicating oxidative stress, and the aryl hydrocarbon receptor (AhR). Endocrine disruption was also observed through the activation of estrogenic receptor-α (ER-α) and the induction of anti-androgenic activity. The findings show that WEEE plastic-associated chemicals exert effects in multiple subcellular sites, via different receptors and mechanisms. Thus, an integrated approach employing both chemical and toxicological methods is essential for comprehensive assessment of the toxicity mechanisms and cumulative chemical burden of WEEE plastic-associated chemicals.}, issn = {0013-9351} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssonmartin_2025, title = {Decoding school marketisation : exploring computational analytics in large-scale policy data}, author = {Karlsson, Martin and Borgström, Eric and Lundahl, Christian}, year = {2025}, journal = {Learning, Media & Technology}, pages = {1--17}, doi = {10.1080/17439884.2025.2505555}, url = {1960946}, language = {eng}, publisher = {Routledge}, keywords = {school marketisation; omputational text analysis; parliamentary debate; swedish education policy; large language models (llms)}, abstract = {Over the past four decades, Sweden's education system has undergone a profound transformation, shifting from a centralised structure to a market-oriented model characterised by independent schools, deregulation, and competition. This paper introduces an innovative methodological approach to studying this transformation by applying computational text analysis with large language models (LLMs) to 45 years of parliamentary debates. By leveraging these methods and extensive parliamentary open data, we identify thematic patterns, ideological shifts, and policy discourses that have shaped the marketisation of Swedish education. Our methodological contribution lies in demonstrating how LLMs can be employed to scale up traditional discourse analysis, bridging the gap between computational methods and qualitative interpretative approaches. We engage critically with the challenges of algorithmic opacity, validation strategies, and interpretative transparency, addressing concerns about bias and the risks of black-boxed analyses. Combining machine-assisted text analysis with traditional qualitative methodologies, we present a scalable yet nuanced framework for studying education policy debates over time.}, issn = {1743-9884} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_borgstrmeric_2025, title = {Decoding School Marketization : Exploring Computational Analytics in Large-Scale Policy Data}, author = {Borgström, Eric and Karlsson, Martin and Lundahl, Christian}, year = {2025}, journal = {Learning, Media & Technology}, doi = {10.1080/17439884.2025.2505555}, url = {1957472}, language = {eng}, publisher = {Routledge}, keywords = {school marketisation; computational text analysis; parliamentary debate; swedish education policy; large language models (llms)}, abstract = {Over the past four decades, Sweden's education system has undergone a profound transformation, shifting from a centralised structure to a market-oriented model characterised by independent schools, deregulation, and competition. This paper introduces an innovative methodological approach to studying this transformation by applying computational text analysis with large language models (LLMs) to 45 years of parliamentary debates. By leveraging these methods and extensive parliamentary open data, we identify thematic patterns, ideological shifts, and policy discourses that have shaped the marketisation of Swedish education. Our methodological contribution lies in demonstrating how LLMs can be employed to scale up traditional discourse analysis, bridging the gap between computational methods and qualitative interpretative approaches. We engage critically with the challenges of algorithmic opacity, validation strategies, and interpretative transparency, addressing concerns about bias and the risks of black-boxed analyses. Combining machine-assisted text analysis with traditional qualitative methodologies, we present a scalable yet nuanced framework for studying education policy debates over time.}, issn = {1743-9884} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_petrimarceloheron_2025, title = {Decoding the ankle-brachial index in peripheral artery disease : coronary versus valvular calcification}, author = {Petri, Marcelo Heron and Haftbaradaran Esfahani, Payam and Plunde, Oscar and Bäck, Magnus}, year = {2025}, journal = {European Heart Journal Open}, volume = {5}, number = {6}, doi = {10.1093/ehjopen/oeaf134}, url = {2023891}, language = {eng}, publisher = {Oxford University Press} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_hearnjeff_2025_1, title = {Decolonising studies on men, boys, and masculinities, ‘North’ and ‘South’ : A dialogue between Kopano Ratele and Jeff Hearn}, author = {Hearn, Jeff and Ratele, Kopano}, year = {2025}, pages = {59--82}, doi = {10.4324/9781003465300-6}, url = {1998286}, language = {eng}, publisher = {Routledge}, keywords = {global south; global north; men; masculinities; dialogue; decoloniality}, abstract = {Studies on men, boys, and masculinities, critical and feminist or otherwise, have been dominated by the Global North, and especially Anglophone, West-centric, scholarship. In this dialogical chapter, we build on our own earlier collaborative work to examine the contribution of, and challenges and blocks to, furthering decolonising studies on men, boys, and masculinities – both within the ‘Global North’ and ‘Global South,’ and from ‘Global North’ and ‘Global South’ positionalities and perspectives. A vibrant, Southern/non-Global North and non-Anglophone range of scholarship on men, boys, and masculinities now exists, with which we seek to engage. Alongside, in conversation with, and often against the West-centricity of the studies on masculinities, boys, and men, there is an emerging set of studies, literatures, and guidances on decolonial approaches to men, boys, and masculinities that we also engage in our dialogue. We consider the implications of these bodies of scholarly work. We end with an epigraph of some relevant literature.}, file = {https://oru.diva-portal.org/smash/get/diva2:1998286/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bonnetbjrn_2025, title = {Decontamination and Surface Analysis of PFAS-Contaminated Fire Suppression System Pipes : Effects of Cleaning Agents and Temperature}, author = {Bonnet, Björn and Sharpe, Matthew K. and Seisenbaeva, Gulaim and Yeung, Leo W. Y. and Ross, Ian and Ahrens, Lutz}, year = {2025}, journal = {Environmental Science and Technology}, volume = {59}, number = {4}, pages = {2222--2232}, doi = {10.1021/acs.est.4c09474}, url = {1931418}, language = {eng}, publisher = {American Chemical Society (ACS)}, keywords = {afff; per- and polyfluoroalkyl substances; butyl carbitol; desorption; foam transition; rebound effect; supramolecular assemblies; surfactant-surface interactions}, abstract = {Per- and polyfluoroalkyl substances (PFAS)-containing firefighting foam have been used in stationary fire suppression systems for several decades. However, there is a lack of research on how to decontaminate PFAS-contaminated infrastructure and evaluate treatment efficiency. This study assessed the removal of PFAS from stainless steel pipe surfaces using different cleaning agents (tap water, methanol, and aqueous solutions containing 10 and 20 wt % of butyl carbitol (BC)) at different temperatures (20 °C, 40 °C, and 70 °C). The content of the remaining fluorine (F)-containing compounds on the pipe surfaces was evaluated for the first time using time-of-flight elastic recoil detection (ToF-ERD). The results showed that a 20% BC aqueous solution heated to 70 °C removed up to 40 μg/cm2 ∑PFAS from surfaces via soaking (targeted analysis). Treatment with 20% BC was 2- to 8-fold more effective than tap water at 70 °C and 10- to 20-fold more effective than tap water at 20 °C. Total fluorine analysis determined by combustion ion chromatography showed a 2- to 8-fold higher F-equivalent compared to targeted analysis in the cleaning solution after treatment, indicating the presence of a significant amount of polyfluoroalkyl PFAS. Surface analysis with ToF-ERD confirmed partial F removal from pipe surfaces throughout consecutive soaking intervals, with residual F remaining on pipe surfaces after treatment, leaving the risk of PFAS rebound into F-free firefighting foams. Furthermore, supramolecular assemblies of PFAS with at least 70 PFOS molecules/nm2 were identified by ToF-ERD on pipe interior surfaces.}, issn = {0013-936X} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_tianchanghao_2025, title = {Deep Learning Based Topography Aware Gas Source Localization with Mobile Robot}, author = {Tian, Changhao and Wang, Annan and Fan, Han and Wiedemann, Thomas and Luo, Yifei and Yang, Le and Lin, Weisi and Lilienthal, Achim J and Chen, Xiaodong}, year = {2025}, pages = {4380--4386}, doi = {10.1109/ICRA55743.2025.11128134}, url = {2021570}, language = {eng}, publisher = {IEEE}, keywords = {gas source localization; robot olfaction; machine olfaction; cognitive robotics; deep learning; simultaneous localization and mapping (slam)}, abstract = {Gas source localization in complex environments is critical for applications such as environmental monitoring, industrial safety, and disaster response. Traditional methods often struggle with the challenges posed by a lack of environmental topography integration, especially when interactions between wind and obstacles distort gas dispersion patterns. In this paper, we propose a deep learning-based approach, which leverages spatial context and environmental mapping to enhance gas source localization. By integrating Simultaneous Localization and Mapping (SLAM) with a U-Net-based model, our method predicts the likelihood of gas source locations by analyzing gas sensor data, wind flow, and topography of the environment represented by a 2D occupancy map. We demonstrate the efficacy of our approach using a wheeled robot equipped with a photoionization detector, a LIDAR, and an anemometer, in various scenarios with dynamic wind fields and multiple obstacles. The results show that our approach can robustly locate gas sources, even in challenging environments with fluctuating wind directions, outperforming conventional methods by utilizing topography contextual information. This study underscores the importance of topographical context in gas source localization and offers a flexible and robust solution for real-world applications. Data and code are publicly available.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_kikaja_2025, title = {DEEPGRAPHLOG for Layered Neurosymbolic AI}, author = {Kikaj, A. and Marra, G. and Geerts, F. and Manhaeve, R. and De Raedt, Luc}, year = {2025}, volume = {413}, pages = {1551--1558}, doi = {10.3233/FAIA250979}, url = {2028613}, language = {eng}, publisher = {IOS Press}, abstract = {Neurosymbolic AI (NeSy) aims to integrate the statistical strengths of neural networks with the interpretability and structure of symbolic reasoning. However, current NeSy frameworks like DEEPGRAPHLOG enforce a fixed flow where symbolic reasoning always follows neural processing. This restricts their ability to model complex dependencies, especially in irregular data structures such as graphs. In this work, we introduce DEEPGRAPHLOG, a novel NeSy framework that extends PROBLOG with Graph Neural Predicates. DEEPGRAPHLOG enables multi-layer neural-symbolic reasoning, allowing neural and symbolic components to be layered in arbitrary order. In contrast to DEEPGRAPHLOG, which cannot handle symbolic reasoning via neural methods, DEEPGRAPHLOG treats symbolic representations as graphs, enabling them to be processed by Graph Neural Networks (GNNs). We showcase the capabilities of DEEPGRAPHLOG on tasks in planning, knowledge graph completion with distant supervision, and GNN expressivity. Our results demonstrate that DEEPGRAPHLOG effectively captures complex relational dependencies, overcoming key limitations of existing NeSy systems. By broadening the applicability of neurosymbolic AI to graph-structured domains, DEEPGRAPHLOG offers a more expressive and flexible framework for neural-symbolic integration. Code is available at https://github.com/ML-KULeuven/DeepGraphLog. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_berntorpkarolina_2025_1, title = {Deferral of left main coronary artery revascularization via IVUS or coronary physiology : Long-term outcomes from the SWEDEHEART registry}, author = {Berntorp, Karolina and Mohammad, Moman A. and Koul, Sasha and Yndigegn, Troels and Bergman, Sofia and Zwackman, Sammy and Linder, Rikard and Völz, Sebastian and Fröbert, Ole and Erlinge, David and Götberg, Matthias}, year = {2025}, journal = {International Journal of Cardiology}, volume = {419}, doi = {10.1016/j.ijcard.2024.132726}, url = {1913516}, language = {eng}, publisher = {Elsevier}, keywords = {deferral; fractional flow reserve; instantaneous wave-free ratio; intravascular imaging; left main coronary artery}, abstract = {BACKGROUND: Intravascular ultrasound (IVUS) guides deferral decision-making regarding the left main coronary artery (LMCA) and improves outcomes. Further studies regarding coronary physiology to guide revascularization in the LMCA are needed. Our aim was to evaluate the outcome of LMCA deferral using IVUS or coronary physiology via instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR).METHODS: Between January 2014 and February 2022, patients undergoing evaluation with either IVUS or coronary physiology in the LMCA were included from the SWEDEHEART registry. Exclusion criteria were a minimum luminal area < 6 mm2, iFR ≤ 0.89, FFR ≤ 0.80, ad hoc percutaneous coronary intervention of lesions in the LMCA, proximal left anterior descending artery, and proximal circumflex artery, planned elective revascularization, and planned valvular surgery. The primary outcome was major adverse cardiac events (MACE), defined as a composite of all-cause death, myocardial infarction, and unplanned revascularization. Kaplan-Meier event rates and multivariable Poisson regression were used for the statistical analyses.RESULTS: Deferral of revascularization in the LMCA was performed in 1552 patients, 33.6 % with IVUS and 66.4 % with coronary physiology (iFR 11.3 % vs. FFR 55.0 %). The median follow-up time was 2.7 years. No significant difference was seen in MACE (IVUS 40.2 % vs. coronary physiology 35.5 %; adjusted RR: 1.18; 95 %CI: 0.97-1.44; p = 0.09). The results were consistent across all investigated subgroups. The rate of all-cause death was higher in the IVUS group (adjusted RR: 1.38; 95 %CI: 1.03-1.83; p = 0.03).CONCLUSIONS: Deferral of coronary revascularization in LMCA lesions using IVUS or coronary physiology did not differ in our combined endpoint. We observed a higher risk of all-cause death using IVUS.}, issn = {0167-5273} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rostamielham_2025, title = {Defining Actionable Advice in Information Security Policies - Guiding Employees to Strengthen Digital Sovereignty of Organizations}, author = {Rostami, Elham and Hanif, Muhammad and Karlsson, Fredrik and Gao, Shang}, year = {2025}, journal = {Procedia Computer Science}, volume = {254}, pages = {30--38}, doi = {10.1016/j.procs.2025.02.061}, url = {1978895}, language = {eng}, publisher = {Elsevier}, keywords = {actionable advice; information security policy; operational policy; compliance; cyber security policy}, abstract = {In today's digital age, protecting information assets is critical to maintain organizations’ digital sovereignty. Yet existing research offers limited guidance on creating effective, actionable advice in information security policies (ISPs) that instructs employees on how to carry out their tasks and contribute to protecting information assets. Addressing this gap, the aim of this paper is to propose a definition of actionable advice. A clear definition can aid in designing ISPs and enhance communication with employees, guiding them in the expected behavior to protect the organization’s information assets. The research question guiding this work is: how can actionable advice be defined in information security policies? To achieve this aim, the definition is informed by a literature review and analysis of 47 ISPs from public agencies in Sweden. The proposed definition of actionable advice is: a demarcated part of an ISP, that instructs someone on a task to execute or not to execute regarding information security, and, in case of execution, how to carry out the task. The definition of actionable advice provides researchers with a starting point to understand this term, helping advancing future studies on ISPs. This work also has practical implications for ISP developers, offering guidance on writing pieces of actionable advice that are concrete and directly applicable in employees' daily tasks to protect their organizations.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_abushammasuha_2025, title = {Definitions, Diagnosis and Management of Postoperative Recurrence in Crohn's Disease Patients with Permanent Ileostomy : A Systematic Review and Meta-Analysis}, author = {Abushamma, Suha and Yadete, Tesfaye and Nero, Neil and Falloon, Katherine and Parker, Claire E. and Abreu, Maria T. and Ahuja, Vineet and Armuzzi, Alessandro and Bemelman, Willem and Bruining, David H. and Deepak, Parakkal and Dignass, Axel and Dotan, Iris and Feagan, Brian G. and Fulmer, Clifton and Halfvarson, Jonas and Hart, Ailsa and Holubar, Stefan D. and Leong, Rupert W. and Ma, Christopher and Magro, Fernando and McCurdy, Jeffrey D. and Narula, Neeraj and Panés, Julian and Raine, Tim and Regueiro, Miguel and Rogler, Gerhard and Singh, Siddharth and Sparrow, Miles P. and Spinelli, Antonino and Van Koughnett, Julie Ann and Vuyyuru, Sudheer K. and Solitano, Virginia and Yuan, Yuhong and Jairath, Vipul and Rieder, Florian}, year = {2025}, journal = {Journal of Crohn's & Colitis}, volume = {19}, number = {4}, doi = {10.1093/ecco-jcc/jjaf041}, url = {1943891}, language = {eng}, publisher = {Oxford University Press}, keywords = {crohn’s disease; ileostomy; recurrence}, abstract = {BACKGROUND AND AIMS: Over 10% of patients with Crohn's disease require permanent ileostomy. We aimed to summarize the existing data on diagnosis, definitions of recurrence, and management of Crohn's disease patients with permanent ileostomy.METHODS: MEDLINE, Embase, and CENTRAL databases were searched from inception to February 6, 2024. Randomized controlled trials, cohort and cross-sectional studies, and case series of more than five patients reporting on postoperative recurrence or the need for surgery in patients with Crohn's disease and permanent ileostomy were included. Search results were independently screened, and full text of all titles meeting eligibility criteria were obtained. Outcomes of interest included diagnostic techniques, recurrence definitions, and management approaches. We estimated pooled rates [with 95% confidence interval] of recurrence.RESULTS: Thirty cohort studies including 2,055 Crohn's patients with permanent ileostomy were included (53% female, median age at time of ileostomy creation 32 years, most common reason for ileostomy was refractory disease). The postoperative recurrence rate was 27% (95% CI, 21.3-33.3, 26 studies, 451/1805 patients). Modalities for diagnosis of Crohn's disease recurrence were symptoms (15 studies), endoscopy (4 studies), histology from endoscopic biopsies (2 studies), imaging (5 studies) and surgery (22 studies). The reported definitions of recurrence for each modality were heterogeneous.CONCLUSIONS: There is a lack of standardized monitoring tools and criteria for diagnosing recurrence in patients with Crohn's disease and permanent ileostomy. The results of this systematic review will form the basis of a global expert recommendation exercise focused on developing management standards and trial endpoints for this condition.}, issn = {1873-9946} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_thunbergulrica_2025_1, title = {Degree of Preoperative Bilateral Hearing Affects Patient-Reported Outcome in Primary Stapedotomy}, author = {Thunberg, Ulrica and Taj, Tahir and Redfors, Ylva Dahlin and Finizia, Caterina}, year = {2025}, journal = {Otology and Neurotology}, volume = {46}, number = {3}, pages = {265--271}, doi = {10.1097/MAO.0000000000004413}, url = {1926511}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, keywords = {otosclerosis; quality indicators; stapedotomy; surgical register}, abstract = {OBJECTIVE: To investigate whether degree of asymmetric hearing impairment influences patient-reported outcome measures and objective hearing results in primary stapedotomy. STUDY DESIGN: Register study.SETTING: Data from the Swedish Quality Register for Otosclerosis Surgery consisting of 90% of stapes operations performed in Sweden.MAIN OUTCOME MEASURE: The 984 patients eligible for inclusion were categorized on the basis of preoperative hearing impairment: unilateral, bilateral asymmetric, or bilateral symmetric. Pure-tone audiometry and patient-reported outcome measures were analyzed, and Glasgow benefit plots were constructed. Ordinal logistics regression analyses were performed to adjust for factors influencing PROMs associated with degree of asymmetric hearing.RESULTS: Over 90% of patients across all groups reported improved or much improved hearing ability post-surgery. Ninety-five percent of patients who rated their hearing as worse or much worse after surgery had an air-conductive gain of <20 dB PTA4. Individuals with unilateral hearing impairment were more likely to report lower satisfaction with hearing function and daily life activities after surgery compared with those with bilateral hearing impairment, especially bilateral symmetric hearing impairment. In terms of hearing function, the bilateral symmetric hearing impairment group showed a significant decrease in the log odds of reporting lower satisfaction with a coefficient of -0.71 (95% confidence interval, -1.13 to -0.33), whereas the bilateral asymmetric hearing impairment group showed a nonsignificant decrease with a coefficient of -0.14 (95% confidence interval, -0.41 to 0.14) compared with the unilateral hearing impairment group. Tinnitus was more frequent in those with unilateral hearing impairment.CONCLUSION: Those with preoperative unilateral hearing impairment were more likely to express lower satisfaction with the results, compared with patients with bilateral impairment. Our findings suggest that the degree of bilateral hearing impairment should be considered in preoperative counseling, to better align with patient expectations regarding the benefit of surgery. An estimated air-conductive gain of at least 20 dB PTA4 was favorable for patient satisfaction.}, issn = {1531-7129} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bergjenny_2025, title = {Democracy as a cause of semi-presidential regimes : On reverse causality between democracy and semi-presidential establishment}, author = {Åberg, Jenny and Denk, Thomas}, year = {2025}, journal = {International Political Science Review}, volume = {46}, number = {2}, pages = {299--315}, doi = {10.1177/01925121241281943}, url = {1912047}, language = {eng}, publisher = {Sage Publications}, keywords = {semi-presidential regime; premier-presidential regime; president-parliamentary regime; uncertainty; constitutional choice; democracy; democratization}, abstract = {This article re-examines the relationship between democracy and semi-presidential regimes. While numerous scholars have traced the effects of semi-presidential regimes on democracy, few have addressed the risk of reverse causality, namely, that democracy influences the establishment of semi-presidential regimes. This article uses statistical analyses to test whether the level of democracy in a country affects its choice of semi-presidential regime subtype: a premier-presidential or a president-parliamentary. Including all semi-presidential regimes from 1919 until 2015 and controlling for other conditions such as colonial legacy, the level of development and regime diffusion, our results confirm the hypothesis. The higher the level of democracy - the higher the probability of a premier-presidential regime. Our results underline that democracy is a highly influential cause of the type of semi-presidential regime chosen, a conclusion that places a question mark on the self-evident use of the semi-presidential subtypes as an independent variable.}, issn = {0192-5121} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_jusufiilir_2025, title = {Democratizing Upper Limb Rehabilitation : XR and AI in Every Pocket}, author = {Jusufi, Ilir and Memedi, Mevludin}, year = {2025}, doi = {10.1109/ISMAR-Adjunct68609.2025.00077}, url = {2018573}, language = {eng}, publisher = {IEEE}, abstract = {Upper limb motor impairments require consistent assessment and rehabilitation across diverse patient populations including stroke, brain injuries, Parkinson’s disease, among others. However, traditional approaches are often constrained by cost, limited access, therapist availability, and lack of scalability. In this position paper, we argue that a modular, smartphone-based system that leverages augmented reality (AR) and artificial intelligence (AI) represents a transformative opportunity to guide motor tasks, collect movement data, and deliver personalized feedback. The system architecture includes a client-side AR app with gamified motor tasks, a cloud backend with machine learning capabilities, and a web-based clinician dashboard for review and human-in-the-loop data labeling. Representative AR tasks target specific motor functions such as reach, coordination, and postural control, enabling fine-grained tracking of upper limb dysfunctions and empowerment of users to take control of their recovery while supporting clinicians with valuable data to track the performance and progress of their patients. By utilizing devices already in patients’ hands, AR, and AI, this approach supports remote, low-cost, and extensible rehabilitation—bringing scalable digital therapy closer to everyday use by democratizing access to care and improving outcomes of people living with upper limb impairments.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_jmtejan_2025, title = {Den antirasistiska rörelsen}, author = {Jämte, Jan}, year = {2025}, pages = {241--260}, url = {1967864}, language = {swe}, publisher = {Studentlitteratur AB}, keywords = {antirasism; rasism; sociala rörelser; politisk aktivism; protester}, abstract = {Det senaste seklet har den antirasistiska rörelsen engagerat tiotusentals människor mot uttryck för rasism. Problembilderna har varit många: nazisters hat och våld, radikalnationalistisk politik, rasistiska kränkningar i vardagen och missgynnande av etniska minoriteter och flyktingar.Samtidigt som rörelsen samlat breda folklager har den också varit om gärdad av kontroverser. Få andra rörelser har haft en så tydlig och våldsam motpart, vilket har höjt konfliktnivån och aktualiserat frågan om våldets roll i sociala rörelser. Delar av rörelsen har också alltid förstått rasismen som strukturell, vilket satt i fråga både den institutionaliserade politiken och efterkrigstidens självbild av Sverige som ett land fritt från rasism.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssondahlnichelle_2025, title = {Den marknadsförda folkmusikvärlden : Tradition, nyskapande och normförhandling i folkmusikalisk konsertpraktik}, author = {Johansson Dahl, Nichelle}, year = {2025}, url = {2013677}, language = {swe}, abstract = {Oavsett musikgenre så finns det sådant som anses vara rätt och sådant som anses vara fel, och idéer om vad som är legitima sätt att vara i och kring musiken. Den svenska folkmusiken är inget undantag – den konstrueras kring vedertagna sanningar och villkor, understödda av mångåriga föreställningar och institutioner. Detta har lett till en folkmusikgenre som idag är präglad av otaliga spänningsfält, normer och ideal vad gäller såväl social inkludering och/eller exkludering som musikalisk tolkning och framförande. Folkmusikeryrket innebär följaktligen att navigera bland dessa spänningsfält, i kombination med musikeryrkets hårda konkurrens. Att nå ut med sin musik och säkra spelningarna – inkomsterna – medför därför ett behov av att synas och att positionera sig som just yrkesaktiv folkmusiker genom en mängd konsertpraktiker, såsom marknadsföring i text och bild.I presentationen redogör jag för den första delstudien av min avhandling i musikvetenskap om normer och ideal inom folkmusikalisk konsertpraktik. Delstudien bygger på en kritisk multimodal diskursanalys av 19 samtida folkmusikers marknadsföringsmaterial i form av pressfoton, konsertbeskrivningar, hemsidor och skivomslag, utifrån frågorna: Hur representeras svensk folkmusik och dess professionella aktörer? Vilka föreställningar om folkmusik och dess aktörer görs begripliga och önskvärda, och hur artikuleras motberättelser till dominerande normer och ideal i multimodala framställningar?Hur vi tänker och talar om musik formar hur musiken upplevs och vilka betydelser den tillskrivs. Det vi vet om musiken är omöjligt att bortse ifrån och blir en integrerad del av musikupplevelsen. Konsertpraktiker såsom marknadsföringsmaterial och skivomslag är alltså sätt att kommunicera idéer om musiken, aktörerna och vilka kulturella betydelser de innehar. Musikerrollen innebär därför en maktposition, som genom konsertpraktiker såsom marknadsföringsbilder och texter både positionerar musikern och upprätthåller och ifrågasätter genrens normer och ideal.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_jmtejan_2025_1, title = {Den radikala vänstern}, author = {Jämte, Jan and Lundstedt, Måns}, year = {2025}, pages = {181--200}, url = {1967877}, language = {swe}, publisher = {Studentlitteratur AB}, keywords = {radikala vänstern; nya vänstern; anarkism; kommunism; autonom; sociala rörelser; politiska protester}, abstract = {Den radikala vänstern har ristat in sig i den allmänna historieskrivningen genom några av efterkrigstidens mest kontroversiella politiska händelser: Båstadskravallerna 1968, almstriden 1971, 1990-talets turbulenta demonstrationer kring 30 november och upploppen i samband med EU-toppmötet i Göteborg 2001, för att nämna några.Men här finns också en annan historia, bortom konfrontationer och medierubriker. Rörelsens vardag handlar om generationer av aktivister som på en mängd olika sätt engagerat sig mot upplevd ojämlikhet och orättvisa. Man har riktat udden mot kapitalism och klasskillnader, mot rasism och sexism, mot miljöför­ störelse och mycket annat – både i Sverige och i övriga världen. På vägen har man utvecklat teorier och spänningsfyllda idéer om hur samhällsproblemen ser ut, hur samhället borde vara och hur man kan arbeta för att nå dit.Sammantaget tecknar kapitlet bilden av en bred rörelse med många uttryck och förgreningar som ofta spelat rollen som radikal pådrivare inom och kring andra rörelser. På så sätt har den radikala vänstern lämnat avtryck långt utanför de egna sakpolitiska områdena och haft en central betydelse för i stort sett alla andra rörelser i denna bok} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_troumpoukisantonis_2025, title = {DeployAI : AI-on-Demand Platform and Marketplace for Industrial Applications within Europe}, author = {Troumpoukis, Antonis and Marinakis, Achilleas and Gizelis, Christos A. and Sofikitis, Konstantinos and Mouzakitis, Spiros and Pountridis, Theodosios and Tzortzis, Alexandros-Menelaos and Karakolis, Evangelos and Pelekis, Sotiris and Albughdadi, Mohanad and Baousis, Vasileios and Köckemann, Uwe and Papastergiou, Fotis and Tzoumas, Alexandros and Welss, Martin}, year = {2025}, volume = {753}, pages = {115--127}, doi = {10.1007/978-3-031-97317-8_9}, url = {2002872}, language = {eng}, publisher = {Springer}, keywords = {platform; cloud & hpc infrastructures; applications; marketplace}, abstract = {The DeployAI project develops a fully operational European AI-on-Demand Platform (AIoDP) to empower European industry-particularly SMEs and the public sector-with access to cutting-edge AI solutions. Focusing on European-developed, trustworthy, and ethical AI technologies, the AIoDP offers a comprehensive marketplace of AI products and services, including pre-trained models, tools, and reusable modules, supporting scalable deployment across Cloud and HPC infrastructures. The platform also features a Business Navigator, offering insights into the European AI ecosystem through interactive data and stakeholder mapping. Real-world use cases across Energy, Smart Cities, Earth Observation, and Logistics demonstrate the platform's potential to accelerate AI adoption, enhance productivity, and foster innovation within the European AI ecosystem.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonpeter_2025, title = {Depolarized Forward Light Scattering for Subnanometer Precision in Biomolecular Layer Analysis on Gold Nanorods}, author = {Johansson, Peter and Käll, Mikael and Šípová-Jungová, Hana}, year = {2025}, journal = {The Journal of Physical Chemistry Letters}, volume = {16}, number = {5}, pages = {1288--1295}, doi = {10.1021/acs.jpclett.4c02956}, url = {1932174}, language = {eng}, publisher = {American Chemical Society (ACS)}, keywords = {alcohols; layers; nanoparticles; nanorods; thickness}, abstract = {Functional gold nanoparticles have emerged as a cornerstone in targeted drug delivery, imaging, and biosensing. Their stability, distribution, and overall performance in biological systems are largely determined by their interactions with molecules in biological fluids as well as the biomolecular layers they acquire in complex environments. However, real-time tracking of how biomolecules attach to colloidal nanoparticles, a critical aspect for optimizing nanoparticle function, has proven to be experimentally challenging. To address this issue, we present a depolarized forward light scattering (DFLS) method that measures rotational relaxation constants. In DFLS, optically anisotropic nanoparticles are illuminated with linearly polarized light and the forward light scattering is analyzed in a cross-polarized configuration. We demonstrate the application of DFLS to characterize various functional coatings, analyze biomolecular binding kinetics to gold nanoparticles, and determine specific protein adsorption affinity constants. Our results indicate that DFLS offers a powerful approach to studying nanoparticle-biomolecule interactions in complex environments such as bodily fluids, thereby opening new pathways for advancements in nanomedicine and the optimization of nanoparticle-based drug delivery systems.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wielswietsea_2025, title = {Depressive Symptoms and Amyloid Pathology}, author = {Wiels, Wietse A. and Oomens, Julie E. and Engelborghs, Sebastiaan and Baeken, Chris and von Arnim, Christine A. F. and Boada, Mercè and Didic, Mira and Dubois, Bruno and Fladby, Tormod and van der Flier, Wiesje M. and Frisoni, Giovanni B. and Fröhlich, Lutz and Gill, Kiran Dip and Grimmer, Timo and Hildebrandt, Helmut and Hort, Jakub and Itoh, Yoshiaki and Iwatsubo, Takeshi and Klimkowicz-Mrowiec, Aleksandra and Lee, Dong Young and Lleó, Alberto and Martinez-Lage, Pablo and de Mendonça, Alexandre and Meyer, Philipp T. and Kapaki, Elisabeth N. and Parchi, Piero and Pardini, Matteo and Parnetti, Lucilla and Popp, Julius and Rami, Lorena and Reiman, Eric M. and Rinne, Juha O. and Rodrigue, Karen M. and Sánchez-Juan, Pascual and Santana, Isabel and Sarazin, Marie and Scarmeas, Nikolaos and Skoog, Ingmar and Snyder, Peter J. and Sperling, Reisa A. and Villeneuve, Sylvia and Wallin, Anders and Wiltfang, Jens and Zetterberg, Henrik and Ossenkoppele, Rik and Verhey, Frans R. J. and Vos, Stephanie J. B. and Visser, Pieter Jelle and Jansen, Willemijn J.}, year = {2025}, journal = {JAMA psychiatry}, volume = {82}, number = {3}, pages = {296--310}, doi = {10.1001/jamapsychiatry.2024.4305}, url = {1932359}, language = {eng}, publisher = {American Medical Association (AMA)}, abstract = {IMPORTANCE: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology.OBJECTIVE: To examine the association between depressive symptoms and amyloid pathology and its dependency on age, sex, education, and APOE genotype in older individuals without dementia.DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional analyses were performed using data from the Amyloid Biomarker Study data pooling initiative. Data from 49 research, population-based, and memory clinic studies were pooled and harmonized. The Amyloid Biomarker Study has been collecting data since 2012 and data collection is ongoing. At the time of analysis, 95 centers were included in the Amyloid Biomarker Study. The study included 9746 individuals with normal cognition (NC) and 3023 participants with mild cognitive impairment (MCI) aged between 34 and 100 years for whom data on amyloid biomarkers, presence of depressive symptoms, and age were available. Data were analyzed from December 2022 to February 2024.MAIN OUTCOMES AND MEASURES: Amyloid-β1-42 levels in cerebrospinal fluid or amyloid positron emission tomography scans were used to determine presence or absence of amyloid pathology. Presence of depressive symptoms was determined on the basis of validated depression rating scale scores, evidence of a current clinical diagnosis of depression, or self-reported depressive symptoms.RESULTS: In individuals with NC (mean [SD] age, 68.6 [8.9] years; 5664 [58.2%] female; 3002 [34.0%] APOE ε4 carriers; 937 [9.6%] had depressive symptoms; 2648 [27.2%] had amyloid pathology), the presence of depressive symptoms was not associated with amyloid pathology (odds ratio [OR], 1.13; 95% CI, 0.90-1.40; P = .29). In individuals with MCI (mean [SD] age, 70.2 [8.7] years; 1481 [49.0%] female; 1046 [44.8%] APOE ε4 carriers; 824 [27.3%] had depressive symptoms; 1668 [55.8%] had amyloid pathology), the presence of depressive symptoms was associated with a lower likelihood of amyloid pathology (OR, 0.73; 95% CI 0.61-0.89; P = .001). When considering subgroup effects, in individuals with NC, the presence of depressive symptoms was associated with a higher frequency of amyloid pathology in APOE ε4 noncarriers (mean difference, 5.0%; 95% CI 1.0-9.0; P = .02) but not in APOE ε4 carriers. This was not the case in individuals with MCI.CONCLUSIONS AND RELEVANCE: Depressive symptoms were not consistently associated with a higher frequency of amyloid pathology in participants with NC and were associated with a lower likelihood of amyloid pathology in participants with MCI. These findings were not influenced by age, sex, or education level. Mechanisms other than amyloid accumulation may commonly underlie depressive symptoms in late life.}, issn = {2168-6238} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_xuqichen_2025, title = {Design of 2D skyrmionic metamaterials through controlled assembly}, author = {Xu, Qichen and Shen, Zhuanglin and Edström, Alexander and Miranda, I. P. and Lu, Zhiwei and Bergman, Anders and Thonig, Danny and Yin, Wanjian and Eriksson, Olle and Delin, Anna}, year = {2025}, journal = {npj Computational Materials}, volume = {11}, number = {1}, doi = {10.1038/s41524-025-01534-4}, url = {1945538}, language = {eng}, publisher = {Springer Nature}, abstract = {Despite extensive research on magnetic skyrmions and antiskyrmions, a significant challenge remains in crafting nontrivial high-order skyrmionic textures with varying, or even tailor-made, topologies. We address this challenge, by focusing on a construction pathway of skyrmionic metamaterials within a monolayer thin film and suggest several skyrmionic metamaterials that are surprisingly stable, i.e., long-lived, due to a self-stabilization mechanism. This makes these new textures promising for applications. Central to our approach is the concept of 'simulated controlled assembly', in short, a protocol inspired by 'click chemistry' that allows for positioning topological magnetic structures where one likes, and then allowing for energy minimization to elucidate the stability. Utilizing high-throughput atomistic-spin-dynamic simulations alongside state-of-the-art AI-driven tools, we have isolated skyrmions (topological charge Q = 1), antiskyrmions (Q = - 1), and skyrmionium (Q = 0). These entities serve as foundational 'skyrmionic building blocks' to form the here-reported intricate textures. In this work, two key contributions are introduced to the field of skyrmionic systems. First, we present a novel combination of atomistic spin dynamics simulations and controlled assembly protocols for the stabilization and investigation of new topological magnets. Second, using the aforementioned methods we report on the discovery of skyrmionic metamaterials.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_chatzipetroupanagiota_2025, title = {Designing a Practical Course from a Gamification Perspective : Students’ Insights from Informatics Education}, author = {Chatzipetrou, Panagiota and Moll, Jonas and Gao, Shang}, year = {2025}, pages = {60--69}, url = {2026412}, language = {eng}, publisher = {Academic Conferences and Publishing International}, keywords = {gamification; motivation; engagement; bonus points; informatics}, abstract = {Gamification is a powerful instrument in the educational process if applied with care, considering the holistic learning experience. Literature has shown that using game-based mechanisms can motivate and engage students to participate actively in the learning process. This study investigates students’ motivation and engagement to participate in practical courses developed based on a holistic gamification approach. In this paper, we present the results of a case study in a Swedish university. In one of our practical courses, we designed and implemented gamification concepts (bonus points, real-life scenarios, and role-playing). The course Software Architecture was designed and developed from scratch with the explicit aim of integrating gamification into its structure and delivery. After each lecture, we planned a workshop (with voluntary participation) with gamification elements, applying the learning outcomes. To investigate students’ insights, we distributed a research survey, complementing the general course evaluation survey, at the end of the course, during which 60% of the enrolled students were present (enrolled students:100). In total, we collected 50 responses. The preliminary results show positive statistical significance on the students’ motivation to participate actively and engage in the course; moreover, it encourages positive collaboration among the students and helps students better understand the course content. However, students experience different gamification elements (e.g., bonus points and role-playing) differently, i.e., role-playing seems to make students struggle more to apply it to a real-case scenario. Moreover, there are indications that the implemented gamification approach added extra stress and pressure to the students. We also identify implications that awarding bonus points, which are collected during seminars and used on the final exam, at the group level instead of an individual level, cannot be a fair approach. Overall, the results indicated that the students are motivated and engaged to participate in courses developed with a holistic gamification approach. The study will be replicated with a different group of students and in a theoretical course to better understand how gamification designs can be applied in different types of courses.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vinayakpatilrajesh_2025_1, title = {Detection and Classification of Engine Exhaust Weld Joint Defects Using RNN and SVM on SS316L–SS410 and SS310–SS410}, author = {Vinayak Patil, Rajesh and Löfstrand, Magnus}, year = {2025}, journal = {Journal of Failure Analysis and Prevention}, volume = {25}, pages = {2491--2511}, doi = {10.1007/s11668-025-02292-7}, url = {2002250}, language = {eng}, publisher = {Springer}, keywords = {support vector machine; recurrent neural network; surface features; weld joint imperfection; computer aided graphical user interface (cagui)}, abstract = {Online weld joint inspection by non-destructive testing is necessary for modern joining industries. Nondestructive testing gained popularity through its dominance in examinations and reliability in confirming the part’s excellence. Joining dissimilar metals is preferable in industries due to reduction in the mass of components and less cost of manufacturing using the safety and structural requirements in various applications ranging from automotive to railway and naval trades. The weld joint imperfection examination plays a significant role in the manufacturing industry. A setup of Gas Tungsten Arc Welding (GTAW) has been proposed for joining stainless steel grades of 316L, 310 and 410 thick sheets of 150 × 60 × 3 mm using variable process parameters. An autonomous technique known as Computer Aided Graphical User Interface (CAGUI) has been proposed for online detection and classification of multiform weld joint imperfections precisely comprising of crack, undercut, gas pores, porosity, tungsten inclusion, wormholes, lack of penetration, and non-defects in radiographic images using Support Vector Machine (SVM) and Recurrent Neural Network (RNN) developed using a MATLAB workbench. The support vector machine classifier has classified the weld images by finding the best hyperplane that separates all the weld joint images into defects and non-defect classes. SVM has classified the weld joint defects and non-defect images and confirmed their accuracy performance as 97.50% using the confusion matrix. It confirmed the lack of penetration defects are erroneous for gas pores. A RNN classifier handles the nonlinear weld joint images along with the parallel processing of information and flexibility in system. The feedforward neural network classified weld joint defects and non-defect and confirmed their accuracy performance as 98.75% using a confusion matrix. The confusion matrix confirmed that the lack of penetration defects is erroneous for undercut. The proposed CAGUI improved the computation period without disturbing the correctness of features selection. }, issn = {1547-7029} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_klinteskogmagnus_2025, title = {Detection and molecular characterisation of tick-borne encephalitis virus in CSF and serum in relation to disease severity}, author = {Klinteskog, Magnus and Koskela von Sydow, Anita and Asghar, Naveed and Johansson, Magnus and Henningsson, Anna J. and Sundqvist, Martin and Lindgren, Per-Eric and Ocias, Lukas}, year = {2025}, journal = {Journal of Clinical Virology}, volume = {181}, doi = {10.1016/j.jcv.2025.105885}, url = {2013570}, language = {eng}, publisher = {Elsevier}, keywords = {arboviruses; central nervous system infection; emerging infections; tbe; tick-borne encephalitis}, abstract = {OBJECTIVES: We aimed to 1) detect tick-borne encephalitis virus (TBEV) RNA in clinical samples from patients with TBE, 2) characterise the detected RNA using Sanger sequencing, and 3) examine whether RNA detection was associated with disease severity.METHODS: We studied 137 patients infected and diagnosed with TBE between 2016 and 2021 in Region Örebro County and Region Värmland. Biobanked serum (n = 129) and cerebrospinal fluid (CSF; n = 110) samples were analysed. Serum was tested for TBEV-specific antibodies, and both serum and CSF for TBEV RNA using PCR. Following nested PCR, the 5' non-coding region (5'NCR) of five samples underwent Sanger sequencing. Disease severity was assessed based on intensive care unit (ICU) admission, duration of ICU stay and need for mechanical ventilation.RESULTS: TBEV RNA was detected in 5 serum samples (3.9 %) and 7 CSF samples (6.4 %), representing 10 patients (7.3 %). Patients with detectable RNA were older, more frequently admitted to an ICU (p = 0.04), and more often required mechanical ventilation (p = 0.01) compared to those without detectable TBEV RNA. Sequencing of the 5'NCR in four patients revealed differences from the 5 ´NCR of the Swedish reference strain Torö-2003. The Örebro sequences were identical but differed from the Värmland sequences at two nucleotide positions.CONCLUSIONS: TBEV RNA was detectable in both serum and CSF of TBE patients, and its presence was associated with more frequent ICU admission and need for mechanical ventilation. Sequencing of the 5'NCR revealed genetic variation between TBEV sequences from patients in Örebro and Värmland.}, issn = {1386-6532} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alisaadiasasha_2025, title = {Determinants of physical function, as measured using PROMIS PF-10a, in patients with rheumatoid arthritis : results from the international COVID-19 Vaccination in Autoimmune Diseases (COVAD) study}, author = {Ali, Saadia Sasha and Demetriou, Christiana and Parodis, Ioannis and Tan, Ai Lyn and Edgar Gracia-Ramos, Abraham and Joshi, Mrudula and Caballero-Uribe, Carlo V. and Saha, Sreoshy and Lilleker, James B. and Nune, Arvind and Pauling, John D. and Wincup, Chris and Jagtap, Kshitij and Dey, Dzifa and Milchert, Marcin and Distler, Oliver and Chinoy, Hector and Agarwal, Vikas and Gupta, Latika and Nikiphorou, Elena}, year = {2025}, journal = {Rheumatology: Advances in Practice}, volume = {9}, number = {1}, doi = {10.1093/rap/rkae154}, url = {1931433}, language = {eng}, publisher = {Oxford University Press}, keywords = {covad; promis; country-level income; e-survey; patient-reported outcome measures; physical function; rheumatoid arthritis; sociodemographic factors}, abstract = {OBJECTIVES: Physical function in RA is largely influenced by multiple clinical factors, however, there is a growing body of evidence that psychological state and other comorbidities also play an essential role. Using data obtained in the COVID-19 Vaccination in Autoimmune Diseases study, an international self-reported e-survey, we aimed to explore the predictive ability of sociodemographic and clinical variables on Patient-Reported Outcomes Measurement Information System Physical Function Short Form 10a (PROMIS PF-10a) in RA and to investigate variation in disease activity and functional outcomes based on country-level socio-economic parameters.METHODS: Patient demographics, disease characteristics including current symptom status, functional status and treatment variables, as well as income level of the country of residence, were extracted from survey responses. PROMIS PF-10a scores were compared across country income levels. The influence of extracted variables on reversed PROMIS PF-10a scores were investigated using negative binomial univariable- and multivariable regression. RESULTS: A total of 1342 RA patients were included in this analysis. In the optimised parsimonious predictive model for reversed PROMIS PF-10a, older age, female gender, disease duration, fatigue and pain levels were independently associated with worse physical function, whereas Asian ethnicity, higher overall physical health ratings, ability to carry out everyday activities and residing in a country with an upper-middle or high-income level were independently associated with better physical function.CONCLUSION: Our study highlights that clinical factors remain strong predictors of physical function in RA, irrespective of individual and country-level socio-economic differences. Interestingly, high country-level income was associated with better physical function, irrespective of individual sociodemographic and clinical factors.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_enellanja_2025, title = {Determination of polyoxymethylene (POM) water partition coefficients for DDT and its degradation products, with inter-laboratory comparison of the passive sampling methodology and bioaccumulation in earthworm (Eisenia fetida)}, author = {Enell, Anja and Casey, Stephanie and Au Musse, Ayan and Josefsson, Sarah and Kikuchi-McIntosh, Johannes and Nilén, Greta and Wiberg, Karin and Dahlberg, Anna-Karin and Larsson, Maria}, year = {2025}, journal = {Environmental Chemistry}, volume = {22}, number = {4}, doi = {10.1071/en25011}, url = {1985161}, language = {eng}, publisher = {CSIRO Publishing}, keywords = {aged soil contamination; bioavailability; earthworm toxicity and uptake; equilibrium passive sampling; persistent organic pollutants; pops; pore water concentration; risk assessment}, abstract = {Environmental context: The widespread use of the insecticide DDT has left a legacy of pollution that still threatens ecosystems today. This study presents a method to accurately measure the bioavailability of DDT and its breakdown products in contaminated soils. This will improve risk assessments and guide sustainable land management practices, helping to protect both the environment and human health.Rationale: The insecticide dichlorodiphenyltrichloroethane (DDT) and its degradation products (collectively DDX) are persistent organic pollutants that pose significant environmental risks due to their persistence and bioaccumulation in ecosystems. Accurate quantification of DDX bioavailability in soil systems is crucial for effective land management and risk assessment.Methodology: This study utilised equilibrium passive sampling with polyoxymethylene (POM) to determine the bioavailability of DDX in soil. The sorption dynamics of 10 DDX compounds were investigated (p,p′-DDT, o,p′-DDT, p,p′-dichlorodiphenyldichloroethane (p,p′-DDD), o,p′-DDD, p,p′-dichlorodiphenyldichloroethene (p,p′-DDE), o,p′-DDE, p,p′-dichlorodiphenylmethane (p,p′-DDM), p,p′-dichlorobenzophenone (p,p′-DBP), 1-chloro-2,2-bis(4-chlorophenyl)ethylene (p,p′-DDMU) and dicofol) and their POM–water partition coefficients (KPOM) were determined. The study involved interlaboratory comparisons, using soils from nine historically contaminated sites and ecotoxicology assessments (mortality, reproduction and bioaccumulation in earthworms, Eisenia fetida) to validate the POM method.Results: KPOM values for 9 of the 10 DDX compounds were successfully determined, allowing for accurate quantification of freely dissolved pore water concentrations of DDX in historically contaminated soils. The interlaboratory study highlighted important considerations in extraction and gas chromatography–mass spectrometry analysis, and the ecotoxicology study demonstrated the potential of POM passive sampling as a reliable tool for assessing DDX bioavailability (bioaccumulation in Eisenia fetida).Discussion: The POM method proved to be a robust and reliable approach for quantifying freely dissolved DDX, with implications for improving the accuracy of risk assessments and guiding sustainable land management practices. The study also highlighted the need for careful consideration of analytical challenges, such as the potential degradation of DDX compounds during gas chromatography analysis, to ensure accurate quantification.}, issn = {1448-2517} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bostrmmagnus_2025, title = {Developing action capacity for sufficient consumption among Europeans facing unequal conditions}, author = {Boström, Magnus and Strid, Sofia and Zorell, Carolin and Balkmar, Dag}, year = {2025}, journal = {Frontiers in Sustainability}, volume = {6}, doi = {10.3389/frsus.2025.1629257}, url = {2018579}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {agency-structure; efficiency; sufficiency; sustainable consumption; transformation}, abstract = {This article investigates the conditions under which action-capacity for changing lifestyle patterns toward sufficient consumption can be developed in Europe. The study departs from the recognition that current volumes and patterns of consumption are unsustainable, and that radical lifestyle changes are needed at individual, community, and societal levels. At the same time, European societies are marked by deepening inequalities, with many people living in poverty and hardship who have limited incentives to reduce their already restricted consumption. Against this backdrop, the article asks how bottom-up action-capacity for sustainability transformations can emerge under conditions of constraint. Drawing on theories of efficiency and sufficiency in sustainable consumption, the improve/shift/avoid framework, and concepts of socially embedded agency and reflexivity, the article examines two key domains of the green transition: food (farm-to-fork) and mobility (sustainable transport). The empirical analysis is based on 220 narrative interviews from ten European countries (Austria, Belgium, Germany, Greece, Italy, Norway, Portugal, Romania, Sweden, and Turkey), encompassing people with diverse life situations, including in relative poverty. The findings show that while many narratives reflect efficiency-oriented approaches, they also reveal a wide range of sufficiency strategies. Across contexts, several features of action-capacity were identified, including imagination, responsibility, reflexivity, adaptive capacity, independence, and the pursuit of quality. The article concludes that fostering action-capacity for sufficient consumption and lifestyle change requires multifaceted strategies that integrate individual, social, and institutional efforts, while directly addressing inequalities.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssonjosefine_2025, title = {Developing and Creating Inclusive and Interactive Digital Reading Environments with and for Students with ADHD}, author = {Karlsson, Josefine and Bagger, Anette}, year = {2025}, journal = {Digital Inclusive Learning Materials (DILeMa)}, volume = {1}, number = {1}, pages = {35--51}, doi = {10.11576/dilema-7518}, url = {2018515}, language = {eng}, publisher = {Bielefeld University}, keywords = {digital soloutions; individual needs; reading ability; adhd; inclusive learning; collaboration}, abstract = {Digital solutions are often claimed to have the potential to meet individual needs and make learning more accessible, thereby allowing schools to achieve more sustainable and inclusive learning for a diverse range of learners. However, digital tools bring both affordances and hindrances, which are intertwined with the students’ prerequisites to learn and how the educational space and learning environment are set up. Following this, dilemmas occur as digital materials are assumed to level or reduce obstacles when they, in fact, also generate new obstacles and opportunities. To design and develop these tools with the potential of supporting qualitative learning opportunities for all students, knowledge of inclusivity and digital materials both need to be taken into account, two research fields that are seldom put together. This article contributes by reviewing hindrances to and opportunities for accessible learning in reading through digital materials and through the case of students with ADHD. The article introduces earlier research on the intersection of learning to read, digital materials, and students with ADHD. We thereafter suggest innovative design principles to uphold sustainable use of and learning through digital materials and elaborate on how these principles fit with ideas of inclusion and sus-tainable education. Consequently, the paper provides different stakeholders with the possibility to identify com-monalities in working processes and to reach a joint language to discuss how digital educational tools should be designed and developed. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrnsatu_2025, title = {Developing and testing a framework for matching distinct personality types with information security awareness methods}, author = {Björn, Satu and Jashari, Veronika and Kolkowska, Ella and Gao, Shang}, year = {2025}, journal = {Information and Computer Security}, doi = {10.1108/ICS-03-2025-0091}, url = {1985550}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {information security awareness methods; personality types; learning styles; social influencing vulnerabilities; information security awareness (isa)}, abstract = {Purpose: This study aims to develop and test a framework to associate learning styles and social influencing vulnerabilities with different personality types in the context of tailoring information security awareness (ISA) methods for people with different personality types.Design/methodology/approach: The framework was developed following directed content analysis and applied to match distinct personality types with ISA methods identified through a systematic literature search. The directed content analysis was conducted in two parts: a) Describe and identify keywords for the DISC (dominance [D], inducement [I], submission [S] and compliance [C]) personality types, Kolb's learning styles and Cialdini's social influencing principles; b) Identify the relationships between personality types, learning styles and social influencing vulnerabilities and create the PLS (i.e. personality types, learning styles and social influencing vulnerabilities) framework. As a result, four relationships are identified for each distinct personality type in the PLS framework.Findings: The study has theoretically demonstrated the framework's feasibility of finding best-matched ISA methods for distinct personality types, considering their linked learning style and social influencing vulnerabilities.Research limitations/implications: The study provides two main theoretical contributions: 1) PLS framework: presenting the relationship of personality types with their linked learning style and their social influencing vulnerabilities; 2) Examples of matching distinct personality types with ISA methods, including suggestions for a theoretically best matched ISA method. Therefore, this study contributes to building a sound theoretical ground for tailoring ISA methods for people with different personality types. In addition, the derived keywords are helpful to capture a good understanding of the different dimensions of the selected theories. Furthermore, following the examples provided in this paper, the developed PLS framework can be used as a base for managers to use ISA methods for people with different personality types in organizations.Practical implications: Furthermore, following the examples provided in this paper, the developed PLS framework can be used as a base for managers to employ ISA methods for people with different personality types in organizations.Originality/value: To the best of the authors' knowledge, this study is the first of its kind in developing and testing a framework for matching distinct personality types with information security awareness methods.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_callerstigannecharlott_2025, title = {Developing norm-reflexivity in technical innovation}, author = {Callerstig, Anne-Charlott and Balkmar, Dag and Andersson, Susanne}, year = {2025}, pages = {185--198}, doi = {10.4324/9781003431060-15}, url = {1933944}, language = {eng}, publisher = {Routledge}, keywords = {entrepreneurial ecosystems; gender; entrepreneurship; interactive; norm-critical}, abstract = {Serious concerns have been raised in recent years regarding companies’ inability to recognise diverse customer needs during the development of new services and products. This chapter discusses how implicit and often unreflected social norms about technology users and usage can be addressed in technology user analysis. Based on the findings from a two-year research project with a truck company (Trucks4all), a methodology for increasing norm-reflexivity in technology innovation is introduced. The chapter outlines the interactive process and application of the methodology, and discuss the outcomes, limitations and potentials. Founded on feminist new-institutional theory, gender and technology studies and interactive research methodologies, the chapter contributes with insights on the significance of enhancing norm-awareness to deepen the analysis and understanding of user experiences. It is argued that a so-called norm-critical approach in innovation processes of large corporations, apart from generating new knowledge and inspire technology innovations that challenge existing gendered norms, also impact the wider entrepreneurial ecosystem.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sjholmmaria_2025, title = {Developing the International Law Framework on Maternal Mortality : Ensuring Access to Emergency Obstetric Care and Safe Abortion from Peacetime to Armed Conflict}, author = {Sjöholm, Maria}, year = {2025}, journal = {McGill Journal of Law and Health (MJLH) | Revue de droit et santé de McGill (RDSM)}, volume = {17}, number = {1}, pages = {96--151}, url = {1988566}, language = {eng}, publisher = {McGill University, Faculty of Law}, keywords = {maternal mortality; emergency obstetrics care; abortion; human rights law; humanitarian law; international criminal law; armed conflict; right to health}, issn = {1920-4825}, file = {https://oru.diva-portal.org/smash/get/diva2:1988566/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vanderveerepieterj_2025, title = {Developing Topics}, author = {van der Veere, Pieter J. and van Harten, Argonde C. and van Maurik, Ingrid S. and Teunissen, Charlotte E. and Barkhof, Frederik and Vos, Stephanie J. B. and Frölich, Lutz and Kornhuber, Johannes and Wiltfang, Jens and Maier, Wolfgang and Peters, O. and Rüther, Eckart and Frisoni, Giovanni B. and Spiru, Luiza and Freund-Levi, Yvonne and Wallin, Åsa K. and Hampel, Harald and Tsolaki, Magda and Kłoszewska, Iwona and Mecocci, Patrizia and Vellas, Bruno and Lovestone, Simon and Galluzzi, Samantha and Herukka, Sanna-Kaisa and Santana, Isabel and Baldeiras, Inês and Mendonca, Alexandre and Silva, Dina and Chételat, Gael and Poisnel, Géraldine and Visser, Pieter Jelle and Johnson, Sterling C. and Stomrud, Erik and Hansson, Oskar and Palmqvist, Sebastian and Piñol-Ripoll, Gerard and Berkhof, Johannes and van der Flier, Wiesje M.}, year = {2025}, journal = {Alzheimer's & Dementia: Journal of the Alzheimer's Association}, volume = {21 Suppl 7}, number = {Suppl. 7}, doi = {10.1002/alz70861_108352}, url = {2024502}, language = {eng}, publisher = {Sage Publications}, abstract = {BACKGROUND: Automated cerebrospinal fluid (CSF) biomarker assays have largely replaced manual immunoassays for measuring amyloid pathology. Their relevance is increasing as amyloid-targeting therapies (ATTs) are becoming available for amyloid-positive mild cognitively impaired (MCI) individuals. Therefore, we refitted and validated the ABIDE model, predicting progression from MCI to dementia, with CSF measurements from the automated Elecsys platform. Additionally, we evaluated the performance in an amyloid-positive subpopulation, potentially eligible for ATTs.METHOD: We combined data from MCI participants of seven single-centre and multicentre observational cohorts: Amsterdam Dementia Cohort (n =648), Alzheimer's Disease Neuroimaging Initiative (n =544), BioFINDER (n =212), European Medical Information Framework for Alzheimer's Disease (n =809), Lleida (n =88), National Alzheimer's Coordinating Centre (n =63), and Wisconsin Alzheimer's Disease Cohort (n =9). Participants were included with MCI at baseline, a baseline Mini-Mental State Examination, either a magnetic resonance imaging hippocampal volume or CSF Aβ1-42 and pTau181 measurements, and at least six months of follow-up. Elecsys was used in 737 (31%) participants. A Cox model was used to predict time to dementia using the variables in the previous ABIDE model (Maurik et al. 2019). Model discrimination and calibration were evaluated with leave-one-cohort-out cross-validation. Calibration was assessed in the pooled cohort (PC) and amyloid-positive (APos) subgroup, stratified by predicted risk: PC/APos1 (<P16), PC/APos2 (P16-P50), PC/APos3 (P50-P86), PC/APos4 (>P86).RESULT: Of 2372 MCI participants (Table 1; 70±8yrs, 57%F; 41% amyloid-positive) with a median follow-up of 2.1yrs, 997 (42%; 563 [58%] amyloid-positive) developed dementia (IQR:1.3-3.2yrs). The refitted coefficients resemble the prior model, except for a larger effect of the Aβ1-42*pTau interaction (Table 2). Discrimination was similar to the prior ABIDE model, with Harrell's C of 0.70 (95%CI:0.69-0.71), and calibration was good in the pooled cohort, amyloid-positive subgroup (Figure 1), and across CSF assays. In the amyloid-positive subgroup, all four risk groups had a substantial progression risk with a median predicted progression time of 6.3yrs (95%CI:6.1-6.6) in APos1, 3.7yrs (95%CI:3.5-4.0) in APos2, 3.0yrs (95%CI:2.8-3.0) in APos3, and 2.0yrs (95%CI:2.0-2.1) in APos4.CONCLUSION: We updated the ABIDE model for predicting MCI to dementia progression with automated CSF measurements. The model was well calibrated in amyloid-positive patients and may support clinical discussions regarding the initiation of ATTs.}, issn = {1552-5260} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_omerabubakr_2025_1, title = {Development and Characterization of Novel Antiviral Compounds Based on Plantaricins}, author = {Omer, Abubakr}, year = {2025}, url = {1947278}, language = {eng}, publisher = {Örebro University}, keywords = {antimicrobial peptides; plantaricins; plnc8 αβ; broadspectrum antivirals; emerging and re-emerging viruses; flaviviruses; viral infections; inflammation; virus–bacteria co-infections}, abstract = {The development of novel broad-spectrum antiviral agents is essential for addressing therapeutic gaps in managing common viral infections and the persistent threat of emerging and re-emerging pathogens. This thesis project investigated the antiviral properties of the antimicrobial peptides plantaricins. Study I demonstrated the broad-spectrum activityof PLNC8 ∝β, which disrupted viral envelopes and markedly reduced infectivity, with peptide’s efficacy depending on viral membrane composition. Study II further explored PLNC8 ∝β in a flavivirus infection model, revealing its ability to lower viral loads, attenuate infection-induced cytotoxicity, and modulate inflammation in alveolar epithelial cells. Study III assessed additional plantaricins, identifying truncated variants PLNC8 ∝1-15 and PLNC8 β1-20 as potent antiviral candidates. Synergistic activity was observed in certain complementary two-peptide combinations. Study IV evaluated PLNC8 ∝β’s safety in murine models, demonstrating good local tolerance and a favorable therapeutic window. Intranasal administration was well tolerated, while systemic toxicity occurred at high intravenous doses, highlighting the importance of optimized delivery strategies. Preliminary data on virus–bacteria co-infections indicated that PLNC8 ∝β exerted variable antiviral and antibacterial effects and reduced infection-induced cytotoxicity. Notably, keratinocytes exhibited resistance to the flavivirus Kunjin, suggesting intrinsic viral restriction and underscoring the need for further investigation using advanced models to clarify the role of PLNC8 ∝β in co-infections. Overall, this research supports plantaricins as promising broad-spectrum antiviral candidates. Future studies should focus on optimizing delivery and dosing regimens, exploring synergistic combinations, and applying advanced models to better understand their effects in the context of virus–bacteria co-infections.}, file = {https://oru.diva-portal.org/smash/get/diva2:1947278/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gomezalvaro_2025_1, title = {Development and evaluation of a Register-Based Organ Damage Index in systemic lupus erythematosus : a nationwide, population-based study from Sweden}, author = {Gomez, Alvaro and Parodis, Ioannis and Saleh, Muna and Simard, Julia F. and Sjöwall, Christopher and Arkema, Elizabeth V.}, year = {2025}, journal = {Lupus Science and Medicine}, volume = {12}, number = {1}, doi = {10.1136/lupus-2024-001403}, url = {1941260}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {mortality; outcome assessment; health care; sensitivity and specificity; systemic lupus erythematosus}, abstract = {OBJECTIVE: To develop a Register-Based Organ Damage Index (RBODI) in SLE, and evaluate its accuracy in estimating Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (SDI) scores. Additionally, to describe organ damage accrual and associations with mortality in a Swedish population-based nationwide cohort.METHODS: SDI items were translated into diagnosis, treatment and procedural codes retrieved from Swedish health registers. RBODI was calculated using the same rules as the SDI and its accuracy was evaluated using SDI data from the Clinical Lupus Register in North-Eastern Gothia cohort as the gold standard. Among newly diagnosed patients with SLE from Sweden (2005-2021), we estimated 5-year risks of organ damage, and adjusted HRs of first RBODI-based organ damage accrual associated with patient characteristics. Lastly, we estimated the association between RBODI-based organ damage within 5 years of diagnosis and mortality.RESULTS: The evaluation cohort included 271 prevalent cases (65.3% developed organ damage). RBODI had a positive predictive value of 90%, sensitivity 80% and specificity 83%. Among 4441 newly diagnosed patients with SLE, 40% developed organ damage within 5 years. Males had a 30% higher risk of developing damage compared with females (HR 1.3) and older individuals (>45 years old compared with younger) had more than threefold higher risk (HR 3.3). Early development of organ damage was associated with a 2.1-fold higher risk of mortality.CONCLUSION: Our novel RBODI accurately estimates SDI scores and describes long-term trends in damage accrual in the largest cohort of incident SLE to date. The strong association between early damage accrual and mortality highlights the need for efficient prevention strategies.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ahlanderbrittmarie_2025, title = {Development and fundamental psychometric properties of the Magnetic Resonance Imaging Child-Anxiety Questionnaire (MRIC-AQ)}, author = {Ahlander, Britt-Marie and Årestedt, K. and Christensen, B. M.}, year = {2025}, journal = {Radiography}, volume = {31}, number = {4}, doi = {10.1016/j.radi.2025.102966}, url = {1957604}, language = {eng}, publisher = {Elsevier}, keywords = {child; delphi method; focus groups; item development; reliability; validation study}, abstract = {INTRODUCTION: Magnetic Resonance Imaging is known to provoke anxiety among children, and they may need to be examined with the help of anaesthesia, which has risks. An instrument is needed to evaluate children's anxiety related to a procedure with Magnetic Resonance Imaging. The study aims to adapt and evaluate a children's version of the Magnetic Resonance Imaging-Anxiety Questionnaire.METHODS: The 'Magnetic Resonance Imaging Child-Anxiety Questionnaire' (MRIC-AQ) was drafted by an expert group consisting of a paediatric nurse, a teacher and two radiographers. This version was discussed in focus groups consisting of 10 children between the ages of four and 12 years. The children's suggestions were summarised and analysed using thematic analysis. The revised questionnaire was again discussed with focus groups of children before a paediatric nurse made final readjustments. For a basic psychometric analysis, children undergoing MRI-examinations without anaesthesia were asked to answer the MRIC-AQ.RESULTS: Responses to the questionnaire were gathered from 77 children (girls = 44, boys = 33) aged five to12 years (M = 9.3, SD = 1.7). Only two missing data points were found. The median of the total scale score was 25 (P25-P75 = 21-29), which is below the midpoint of the scale. The Cronbach's alpha was 0.84 (95 % CI = 0.78-0.89).CONCLUSION: The MRIC-AQ has been developed with the help of children. It has satisfactory elementary psychometric properties and will be a useful tool for investigating different interventions for children.IMPLICATIONS FOR PRACTICE: This new instrument (MRIC-AQ) is considered to be of great value when different kinds of interventions are evaluated, all to make MRI examinations as positive an experience as possible. This helps children to undergo examinations without fear.}, issn = {1078-8174} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rutegrdmartin_2025, title = {Development and validation of an anastomotic risk score for use in a randomized clinical trial on defunctioning stoma use in low anterior resection for rectal cancer}, author = {Rutegård, Martin and Myrberg, Ida Hed and Nordenvall, Caroline and Landerholm, Kalle and Jörgren, Fredrik and Matthiessen, Peter and Park, Jennifer and Segelman, Josefin and Buchwald, Pamela and Häggström, Jenny}, year = {2025}, journal = {Colorectal Disease}, volume = {27}, number = {4}, doi = {10.1111/codi.70089}, url = {1951781}, language = {eng}, publisher = {Blackwell Publishing}, keywords = {anastomosis; diverting stoma; insufficiency; leakage; prediction; total mesorectal excision}, abstract = {AIM: The selective use of defunctioning stomas in anterior resection for rectal cancer hinges on accurately predicting anastomotic leakage. The aim of this study was to develop a prediction model for use in a prospective randomized clinical trial.METHOD: Colorectal Cancer Database (CRCBaSe) Sweden was used to identify patients who underwent low anterior resection for rectal cancer 2007-2021. Eligibility criteria mirrored the forthcoming SELective defunctioning Stoma Approach in low anterior resection for rectal cancer (SELSA) trial, including patients <80 years of age and with American Society of Anaesthesiologists' (ASA) physical status grade of <III; further, patients without a defunctioning stoma were excluded. The outcome comprised anastomotic leakage within 30 days or in-hospital. Candidate predictors included age, sex, ASA grade, cardiovascular disease, diabetes, body mass index (BMI), tumour stage, tumour height, and neoadjuvant therapy. Seven models were developed and internally validated using bootstrapping. A threshold of a predicted leakage risk of ≤10% was chosen for trial implementation. Validation was conducted using chart-reviewed data from a nested cohort.RESULTS: Of the 2727 eligible patients, 199 (7.3%) were registered with an anastomotic leakage. All models demonstrated similar performance, with prediction instability observed for risks exceeding 12.5%. The preferred model included three significant predictors: male sex (OR 2.00; 95% CI: 1.45-2.75), BMI >30 kg/m2 (OR 1.82; 95% CI: 1.21-2.74), and radiotherapy (OR 1.90; 95% CI: 1.35-2.69). The bootstrapped area under the curve (AUC) was 0.64 (95% CI: 0.62-0.65), with a negative predictive value of 94.6% (95% CI: 93.7%-95.6%). For the validation cohort, the corresponding estimates were 0.66 (95% CI: 0.59-0.74) and 89.5% (95% CI: 86.2%-92.5%).CONCLUSION: Accuracy of anastomotic leakage prediction using registry-based data is moderate; however, the model's ability to rule out a >10% risk is considered appropriate for trial use.}, issn = {1462-8910} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hollowaysamantha_2025, title = {Development and Validation of the International Skin Tear Advisory Panel Skin Tear Data Collection Tool}, author = {Holloway, Samantha and Fourie, Anika and da Silva, Cinthia Viana Bandeira and Beeckman, Dimitri and Molina-Chailán, Pía and Bresnai-Harris, Julia and Hill, Mary and LeBlanc, Kimberly and Mahoney, Kirsten and Nokaneng, Emmy and Prentice, Jennifer and Samuriwo, Ray and Smet, Steven and Ousey, Karen}, year = {2025}, journal = {Advances in Skin & Wound Care}, volume = {38}, number = {10}, pages = {527--533}, doi = {10.1097/ASW.0000000000000372}, url = {2007780}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, keywords = {acute wounds; incidence; prevalence; skin tears}, abstract = {OBJECTIVE: Numerous studies have examined the epidemiology of skin tears; however, inconsistent definitions, classification systems, and data collection methods have highlighted the need for a validated and standardized tool. The primary objective of this study was to validate a data collection tool for skin tears. A secondary aim was to provide a freely accessible tool for health care providers or researchers to collect consistent and reliable data on skin tears.METHODS: The development of the tool was guided by the 2018 International Skin Tear Advisory Panel (ISTAP) Best Practice Recommendations for the prevention, assessment, and management of skin tears in aged skin. Between June and October 2024, a multimethod validation process was undertaken. Content validity ratio and content validity index calculations were used to quantify content validity, supported by qualitative feedback from 15 experts to assess face validity and provide suggestions for refinement.RESULTS: The final tool consists of 22 questions addressing a patient's demographics, clinical features of the skin tear, associated risk factors, and contextual data. The content validity index was calculated at 0.72, indicating an acceptable level of content validity. International experts reached consensus following a 2-round qualitative review, resulting in subsequent adjustments to the tool.CONCLUSIONS: The ISTAP DC-Tool was developed based on evidence-informed recommendations and validated by an international panel of experts. Its implementation will support health care providers and researchers in gathering standardized epidemiological data contributing to clinical practice improvements, quality initiatives, and further research in skin tear prevention and management.}, issn = {1527-7941} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kervezeelaura_2025, title = {Development of 24-hour rhythms in cortisol secretion across infancy : a systematic review and meta-analysis of individual participant data}, author = {Kervezee, Laura and Romijn, Michelle and van de Weijer, Kirsten N. G. and Chen, Britney S. J. and Burchell, George L. and Tollenaar, Marieke S. and Tamayo-Ortiz, Marcela and Philbrook, Lauren E. and de Weerth, Carolina and Cao, Yang and Rotteveel, Joost and Eiden, Rina D. and Azar, Rima and Bush, Nicole R. and Chis, Adina and Kmita, Grazyna and Clearfield, Melissa W. and Beijers, Roseriet and Gröschl, Michael and Wudy, Stefan A. and Kalsbeek, Andries and Mörelius, Evalotte and Finken, Martijn J. J.}, year = {2025}, journal = {Journal of Clinical Endocrinology and Metabolism}, volume = {110}, number = {2}, pages = {e515--e524}, doi = {10.1210/clinem/dgae590}, url = {1894078}, language = {eng}, publisher = {Oxford University Press}, keywords = {adrenal cortex hormones; adrenal insufficiency; biological clocks; circadian rhythm; cortisol; endocrinology; hydrocortisone; infant}, abstract = {BACKGROUND: In adults, cortisol levels show a pronounced 24-hour rhythm with a peak in the early morning. It is unknown at what age this early-morning peak in cortisol emerges during infancy, hampering the establishment of optimal dosing regimens for hydrocortisone replacement therapy in infants with an inborn form of adrenal insufficiency. Therefore, we aimed to characterize daily variation in salivary cortisol concentration across the first year of life.METHODS: We conducted a systematic review followed by an individual participant data meta-analysis of studies reporting on spontaneous (i.e., not stress induced) salivary cortisol concentrations in healthy infants aged 0-1 year. A one-stage approach using linear mixed-effects modelling was used to determine the interaction between age and time of day on cortisol concentrations.FINDINGS: Through the systematic review, 54 eligible publications were identified, reporting on 29,177 cortisol observations. Individual participant data were obtained from 15 study cohorts, combining 17,079 cortisol measurements from 1,904 infants. The morning/evening cortisol ratio increased significantly from 1.7 (95% CI: 1.3-2.1) at birth to 3.7 (95% CI: 3.0-4.5) at 6-9 months (p < 0.0001). Cosinor analysis using all available data revealed the gradual emergence of a 24-hour rhythm during infancy.INTERPRETATION: The early-morning peak in cortisol secretion gradually emerges from birth onwards to form a stable morning/evening ratio from age 6-9 months. This might have implications for hydrocortisone replacement therapy in infants with an inborn form of adrenal insufficiency.}, issn = {0021-972X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_soegaardknaerke_2025, title = {Development of a clinical practice guideline on pressure ulcers in people with spinal cord injuries inspired by the ADAPTE method}, author = {Soegaard, Knaerke and Beeckman, Dimitri and Verhaeghe, Sofie and Biering-Sørensen, Fin and Sørensen, Jens Ahm}, year = {2025}, journal = {Spinal Cord}, volume = {63}, pages = {66--74}, doi = {10.1038/s41393-024-01051-z}, url = {1920359}, language = {eng}, publisher = {Nature Publishing Group}, abstract = {STUDY DESIGN: Guideline adaptation study using the ADAPTE method. OBJECTIVE: The aim of this study was the development and validation of a Danish clinical practice guideline for PU/PI prevention and treatment for people with SCI through adaptation of existing guidelines.METHODS: The ADAPTE method is a systematic framework used to adapt existing clinical practice guidelines to a new context, such as a different healthcare setting or population. This method ensures that the adapted guidelines are relevant, evidence-based, and practical for the specific context in which they will be implemented.SETTING: Relevant stakeholders and treatment units within the Danish healthcare system involved in the rehabilitation, treatment, and care of people with SCI.RESULTS: The adaptation yielded 22 topics and 121 recommendations, which underwent external review. Stakeholders gave positive feedback and qualified the recommendations. However, they also highlighted challenges in implementation due to the complexity of PU/PI prevention and treatment and organizational issues within the Danish healthcare system.CONCLUSIONS: This study has resulted in the development of a comprehensive Danish clinical practice guideline tailored specifically for the prevention and treatment of PU/PI among people with SCI within the Danish healthcare system. The external review emphasizes the imperative for continuous research aimed at strengthening evidence-based approaches to both prevention and treatment. Furthermore, it highlights the necessity for systematic dissemination strategies to facilitate the integration of the guideline into clinical practice.}, issn = {1362-4393} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vanheckeann_2025, title = {Development of a competency framework for advanced practice nurses : A co-design process}, author = {Van Hecke, Ann and Decoene, Elsie and Embo, Mieke and Beeckman, Dimitri and Bergs, Jochen and Courtens, Annelies and Dancot, Jacinthe and Dobbels, Fabienne and Goossens, Goddelieve Alice and Jacobs, Noortje and Van Achterberg, Theo and Van Bogaert, Peter and Van Durme, Thérèse and Verhaeghe, Sofie and Vlaeyen, Ellen and Goossens, Eva}, year = {2025}, journal = {Journal of Advanced Nursing}, volume = {81}, number = {1}, pages = {353--365}, doi = {10.1111/jan.16174}, url = {1849974}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {advanced practice; clinical nurse specialist; competency framework; co‐design; education; nurse practitioner; professional development; stakeholder}, abstract = {AIMS: The aim of the study was to develop a comprehensive competency framework for advanced practice nurses in Belgium.DESIGN: A co-design development process was conducted.METHODS: This study consisted of two consecutive stages (November 2020-December 2021): (1) developing a competency framework for advanced practice nurses in Belgium by the research team, based on literature and (2) group discussions or interviews with and written feedback from key stakeholders. 11 group discussions and seven individual interviews were conducted with various stakeholder groups with a total of 117 participants.RESULTS: A comprehensive competency framework containing 31 key competencies and 120 enabling competencies was developed based on the Canadian Medical Education Directions for Specialists Competency Framework. These competencies were grouped into seven roles: clinical expert and therapist, organizer of quality care and leader in innovation, professional and clinical leader, collaborator, researcher, communicator and health promoter.CONCLUSION: The developed competency framework has resemblance to other international frameworks. This framework emphasized the independent role of the advanced practice nurse and provided guidance in a clear task division and delegation to other professionals. It can provide a solid foundation for delivering high-quality, patient-centred care by advanced practice nurses in the years to come.IMPLICATIONS FOR THE PROFESSION: This competency framework can guide further development of advanced practice nursing education in Belgium and represents a starting point for future evaluation of its feasibility and usability in education and clinical practice. Advanced practice nurses and healthcare managers can also use the framework as an instrument for personal and professional development, performance appraisal, and further alignment of these function profiles in clinical practice. Finally, this framework can inform and guide policymakers towards legal recognition of advanced practice nursing in Belgium and inspire the development of advanced practice nursing profiles in countries where these profiles are still emerging.IMPACT: What problem did the study address? The absence of a detailed competency framework for advanced practice nurses complicates legal recognition, role clarification and implementation in practice in Belgium. A rigorously developed competency framework could clarify which competencies to integrate in future advanced practice nursing education, mentorship programs and practice. What were the main findings? The competency framework outlined seven roles for advanced practice nurses: clinical expert and therapist, organizer of quality care and leader in innovation, professional and clinical leader, collaborator, researcher, communicator, and health promoter. Differentiation from other expert nursing profiles and clinical autonomy of advanced practice nurses were pivotal. Where and on whom will the research have impact? The comprehensive competency framework for advanced practice nurses and the collaborative methodology used can inspire other countries where these profiles are still emerging. The competency framework can be used as an instrument for role clarification, performance appraisals, continuous professional development, and professional (e-)portfolios. The competency framework can guide policymakers when establishing Belgian's legal framework for advanced practice nurses.REPORTING METHOD: The authors have adhered to CONFERD-HP: recommendations for reporting COmpeteNcy FramEwoRk Development in health professions.PATIENT OR PUBLIC CONTRIBUTION: No patient or public contribution in the design of the study. A patient advisory panel commented on the developed competency framework.}, issn = {0309-2402} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_jaafarrita_2025, title = {Development Of A Novel Live-Attenuated Tick-Borne Encephalitis Vaccine Using The Langat Virus Platform}, author = {Jaafar, Rita and Asghar, Naveed and Merinder, Olivia and Andreassen, Åshild Kristine and Ljungberg, Karl and Nilsson, Charlotta and Taylor, Travis and Melik, Wessam and Johansson, Magnus}, year = {2025}, url = {1999493}, language = {eng}, abstract = {Background: Tick-borne encephalitis (TBE) is a growing public health concern in Europe and Asia, driven by the increasing spread of the TBE virus (TBEV) and its tick vectors. Although current vaccines provide protection, their multi-dose schedule and reduced efficacy in the elderly contribute to occasional vaccine failures. This study aims to develop a novel TBE vaccine offering enhanced protection with fewer doses, focusing on mucosal immunization.Methods: Infectious clone of Langat virus (LGTV IC) was designed and rescued- in our laboratory. We assessed the safety and immunogenicity of the LGTV IC as a live-attenuated TBE vaccine platform in a murine model. Mice were vaccinated with LGTV IC via intranasal or intramuscular routes at low or high doses. We evaluated viremia,viral presence in cerebrospinal fluid, general health, and immune responses.Results: Intranasal immunization with LGTV IC induced strong immune responses. It elicited robust anti-TBEVIgG responses and strong TBEV NS3-specific IFN-γ and IL-2 production. Notably, low-dose intranasal immunization outperformed higher doses of both routes, inducing a more balanced and effective immune response. Low-dose intranasal administration was well tolerated, with no clinical signs, weight loss, or viral presence in the central nervous system. In contrast, intranasal immunization caused potential adverse effects atelevated doses.Conclusion: These findings support LGTV IC as a promising vaccine platform for TBE, with intranasal administration emerging as a putative safe, well-tolerated, and effective needle-free alternative to intramuscular injection when given at a low dose. Ongoing efforts are focused on further attenuating LGTV IC to enhance its safety profile for future applications.}, file = {https://oru.diva-portal.org/smash/get/diva2:1999493/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_abbottallan_2025, title = {Development of a Person-Centred Coordinated Care Pathway in Swedish Healthcare for Low Back Pain}, author = {Abbott, Allan and Forsbrand, Malin and Torstensson, Thomas and Lindström, Ann-Charlotte and Greim, Gudrun and Klaff, Sammy and Niper, Åsa and Karlsson, Marc and Simonsberg, Christian and Engström, Mimmi and Olsson, Tommy and Petersson, Annelie and Ekman, Per and Försth, Peter and Ullmark, Gösta and Linton, Steven J.}, year = {2025}, journal = {International Journal of Integrated Care}, volume = {25}, number = {2}, doi = {10.5334/ijic.8940}, url = {1958448}, language = {eng}, publisher = {Ubiquity Press}, keywords = {care pathway; low back pain; person-centred}, abstract = {INTRODUCTION: This project aimed to develop a Person-Centred Co-ordinated Care (P3C) pathway for low back pain (LBP).DESCRIPTION: A national working group was formed consisting of representatives from all regional healthcare organisations in Sweden and included all relevant healthcare professions, academia, and patient organisations. A mixed method iterative design and consensus approach was applied in the development of the P3C pathway.DISCUSSION: As a foundation, patient interviews along with a review of literature were conducted investigating the evidence base for healthcare interventions, earlier regional care programs/pathways and guidelines in Sweden as well as patient experiences and challenges with healthcare for LBP. Updated evidence-based clinical recommendations, tools supporting the practical use of the national P3C pathway and national healthcare data registry-based quality outcome indicators were then developed. Thereafter, an open consultation period provided review and feedback for final revisions and consensus.CONCLUSIONS: Essential factors for integrating best praxis according to scientific evidence and patient and healthcare professional perspectives were identified to establish a Swedish national P3C pathway for LBP. This provides a novel and innovative example of feasible methodology applicable in the international context. Future research will evaluate potential improvements in healthcare quality outcomes and effectiveness of dissemination and implementation strategies.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_asgharnaveed_2025, title = {Development of Langat virus infectious clones as a platform for live-attenuated tick-borne encephalitis vaccine}, author = {Asghar, Naveed and Jaafar, Rita and Valko, Anna and Merinder, Olivia and Ljungberg, Karl and Lindqvist, Carl Mårten and Johansson, Magnus}, year = {2025}, url = {2008394}, language = {eng}, keywords = {tick-borne encephalitis; tbev; lgtv; rescue; infectious clone; live-attenuated vaccine; reverse genetics}, abstract = { Tick-borne encephalitis (TBE) is one of the most important tick-transmitted diseases in Europe and Asia. TBE virus (TBEV) infections lead to a diversity of disease outcomes ranging from mild flu-like symptoms to severe neurological disorders. With no specific antiviral treatment available, vaccination remains the most effective protective strategy for TBE. Currently, only inactivated TBE vaccines are available on the market, which require repeated booster doses to sustain immunity. In addition, vaccine breakthroughs are reported in some patients, especially in the elderly. In contrary to inactivated vaccines, live-attenuated viral vaccines could provide long-term, or even lifelong immunity after a single dose. Langat virus (LGTV) is a naturally attenuated strain of TBEV, which makes it a potential candidate for a live-attenuated TBE vaccine. In this study, we engineered and rescued four infectious clones (ICs) of LGTV using RNA- and DNA-based reverse genetics methods. Next generation sequencing of the rescued ICs showed that the viruses rescued by DNA-based methods were more similar to the parental LGTV sequence and showed higher genetic stability after passaging in cell culture. One of the DNA-launched LGTV IC was further evaluated in vitro and in vivo which exhibited growth kinetics and immune profile comparable to the LGTV strain in our laboratory. This reverse genetics platform will be utilized to introduce targeted mutations within the LGTV genome to develop a live-attenuated TBE vaccine.}, file = {https://oru.diva-portal.org/smash/get/diva2:2008394/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_asgharnaveed_2025_1, title = {Development of Langat virus infectious clones as a platform for live-attenuated tick-borne encephalitis vaccine}, author = {Asghar, Naveed and Jaafar, Rita and Valko, Anna and Merinder, Olivia and Ljungberg, Karl and Lindqvist, Carl Mårten and Johansson, Magnus}, year = {2025}, journal = {Npj viruses}, volume = {3}, number = {1}, doi = {10.1038/s44298-025-00129-6}, url = {1968213}, language = {eng}, publisher = {Nature Publishing Group}, abstract = {Tick-borne encephalitis (TBE) is one of the most important tick-transmitted diseases in Europe and Asia. With no specific antiviral treatment available, vaccination remains the most effective protective strategy for TBE. Unlike currently available inactivated TBE vaccines that require repeated boosters, live-attenuated vaccines could offer lifelong immunity with a single dose. Langat virus (LGTV) is a naturally attenuated strain of TBE virus (TBEV). In this study, we engineered and rescued four infectious clones (ICs) of LGTV using RNA- and DNA-based reverse genetics methods. The ICs rescued by DNA-based method showed higher genetic stability in cell culture. One of the ICs rescued by DNA-based method was further evaluated in vitro and in vivo, which exhibited growth kinetics and immune profile comparable to the LGTV strain in our laboratory. This reverse genetics platform will be utilized to introduce targeted mutations within the LGTV genome to develop a live-attenuated TBE vaccine.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_falletmanon_2025, title = {Developmental exposure to environmentally relevant PFOS and PFBS disrupts adult behaviour, reproductive fitness, and lipid metabolism in Zebrafish}, author = {Fallet, Manon and Zetzsche, Jonas and Di Criscio, Michela and Yon, Coralie and Aro, Rudolf and Duberg, Daniel and Yeung, Leo W. Y. and Ogunleye, Adeolu and Antczak, Philipp and Scherbak, Nikolai and Rüegg, Joëlle and Hyötyläinen, Tuulia and Keiter, Steffen H.}, year = {2025}, journal = {Environmental Sciences Europe}, volume = {37}, number = {1}, doi = {10.1186/s12302-025-01281-9}, url = {2029083}, language = {eng}, publisher = {Springer}, keywords = {pfas; pollution; zebrafish; behaviour; reproduction; adverse effects; lipidomic}, abstract = {Background: Poly- and perfluoroalkyl substances (PFAS) are persistent pollutants affecting wildlife and biodiversity. Perfluorooctane sulfonic acid (PFOS) and one of its short-chain substitutes, perfluorobutane sulfonic acid (PFBS), are widely found in environmental components, especially in water. PFOS has been highlighted as causing deleterious effects on various organisms while PFBS adversity is suspected but requires further investigation. In this study, zebrafish embryos were exposed from 2 h post-fertilization to 28 days post-fertilization to two different concentrations (0.2 mu g/L and 2 mu g/L) of PFOS or PFBS. We then investigated the impacts of these early exposures later in life on adult fish fitness, growth, morphology, behaviour, and liver lipidomic profiles.Results: PFOS exposure significantly reduced egg production, and both PFOS and PFBS altered growth patterns, organ development, and anxiety-like behaviour. Lipidomic analyses revealed persistent shifts in liver lipid composition that correspond to these phenotypic changes.Conclusions: Taken together, our findings indicate that early-life exposure to low levels of PFOS and PFBS leads to long-term, sex-specific impairments in zebrafish physiology and behaviour, with disruptions in lipid metabolism emerging as a potential underlying mechanism.}, issn = {2190-4707} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_colinsolivierf_2025, title = {Developmental trajectories of conduct problems from childhood to adolescence : Early childhood antecedents and outcomes in adolescence}, author = {Colins, Olivier F. and Fanti, Kostas A. and Hellfeldt, Karin and Frogner, Louise and Andershed, Henrik}, year = {2025}, journal = {Development and psychopathology (Print)}, volume = {37}, number = {5}, pages = {2416--2431}, doi = {10.1017/S0954579424001949}, url = {1939237}, language = {eng}, publisher = {Cambridge University Press}, keywords = {adolescent outcomes; antecedents; conduct problems; cumulative risk; developmental trajectories}, abstract = {Children and adolescents display varying trajectories of conduct problems (CP), but it is unclear if these CP trajectories can be distinguished by childhood antecedents and adolescent outcomes. Therefore, we tested if child- and environmental-level risk factors predict CP trajectory membership and if CP trajectories are associated with developmental outcomes in adolescence. Six waves of data (teacher-, parent- and child self-reports) were used from 2,045 children. General growth mixture modeling identified four CP trajectories (waves 2-5): childhood-persistent, childhood-limited, adolescent-onset, and low CP. Relative to the adolescent-onset CP trajectory, wave 1 child- and environmental-level risk factors increased the likelihood of being in the childhood-persistent CP trajectory, though all but two (callous-unemotional traits and non-intact family) antecedents lost significance after controlling for wave 1 conduct problems. Few significant differences emerged in risk factors when comparing childhood-persistent and childhood-limited CP trajectories. Individuals identified in the adolescent-onset and childhood-persistent CP trajectories faced a higher risk for later maladjustment than those in the childhood-limited CP trajectory, whereas the adolescent-onset and childhood-persistent CP trajectories only differed in three out of 13 outcomes. Overall, findings indicate that individuals with CP are at risk for later maladjustment, but predicting the childhood-persistent trajectory of CP in young children is difficult.}, issn = {0954-5794} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_khanahmadsaeed_2025_1, title = {DFW : a novel weighting scheme for covariate balancing and treatment effect estimation}, author = {Khan, Ahmad Saeed and Schaffernicht, Erik and Stork, Johannes Andreas}, year = {2025}, journal = {Frontiers in Applied Mathematics and Statistics}, volume = {11}, doi = {10.3389/fams.2025.1645805}, url = {2001386}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {propensity score; weighting; confounding; covariate balancing; treatment effect}, abstract = {Estimating causal effects from observational data is challenging due to selection bias, which leads to imbalanced covariate distributions across treatment groups. Propensity score-based weighting methods are widely used to address this issue by reweighting samples to simulate a randomized controlled trial (RCT). However, the effectiveness of these methods heavily depends on the observed data and the accuracy of the propensity score estimator. For example, inverse propensity weighting (IPW) assigns weights based on the inverse of the propensity score, which can lead to instable weights when propensity scores have high variance-either due to data or model misspecification-ultimately degrading the ability of handling selection bias and treatment effect estimation. To overcome these limitations, we propose Deconfounding Factor Weighting (DFW), a novel propensity score-based approach that leverages the deconfounding factor-to construct stable and effective sample weights. DFW prioritizes less confounded samples while mitigating the influence of highly confounded ones, producing a pseudopopulation that better approximates a RCT. Our approach ensures bounded weights, lower variance, and improved covariate balance.While DFW is formulated for binary treatments, it naturally extends to multi-treatment settings, as the deconfounding factor is computed based on the estimated probability of the treatment actually received by each sample. Through extensive experiments on real-world benchmark and synthetic datasets, we demonstrate that DFW outperforms existing methods, including IPW and CBPS, in both covariate balancing and treatment effect estimation.}, file = {https://oru.diva-portal.org/smash/get/diva2:2001386/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_everhovsah_2025_2, title = {Diagnostic accuracy in the Swedish national patient register : a review including diagnoses in the outpatient register}, author = {Everhov, Åsa H. and Frisell, Thomas and Osooli, Mehdi and Brooke, Hannah L. and Carlsen, Hanne K. and Modig, Karin and Mårild, Karl and Lindström, Jonathan and Sköldin, Karin and Heurgren, Mona and Ludvigsson, Jonas F. and Olén, Ola}, year = {2025}, journal = {European Journal of Epidemiology}, volume = {40}, number = {3}, pages = {359--369}, doi = {10.1007/s10654-025-01221-0}, url = {1948197}, language = {eng}, publisher = {Springer}, keywords = {administrative healthcare register; classification of diseases; national patient register; register; register-based epidemiology; sweden; validation studies}, abstract = {BACKGROUND: The Swedish National Patient Register (NPR) is an important source of data for epidemiological research. A review in 2010 described the validity of recorded diagnoses for inpatient care, but did not include specialised outpatient care.METHOD: Using systematic searches of medical literature databases (Embase, Medline), and reports from members of the Swedish Epidemiological Association, we aimed to identify all studies validating diagnoses and procedure codes in inpatient care since 2010 and all studies validating specialised outpatient care. In addition, we summarize findings from register validation work performed by the National Board of Health and Welfare.RESULTS: The literature search and personal reports generated 3990 non-duplicate original studies, of which 89 were deemed relevant. Compared to data in patient charts (reference), the median positive predictive value (PPV) for diagnostic codes in the NPR was 84% (interquartile range 72-93%), but with clear differences between types of diagnoses. The median PPV for surgical procedures was 97% (86-99%). The median sensitivity of diagnoses and procedures compared to other registers and cohorts was 73% (45-80%). The completeness of the register has improved over time. Missingness originates mainly from underreporting of procedures performed by private healthcare providers, and for certain variables, e.g. medication codes.CONCLUSION: The NPR has good diagnostic accuracy for most diagnoses and very good for surgical procedures. The sensitivity is lower. Longitudinal comparisons of incidence or prevalence are affected by changes in completeness. Missingness is low, although it is higher among private healthcare providers and for specific variables such as drug administration.}, issn = {0393-2990} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_soranosumire_2025, title = {Diagnostic accuracy of an antigen-based point-of-care test versus nucleic acid amplification testing for genital trichomoniasis among pregnant women attending antenatal care facilities in Zambia}, author = {Sorano, Sumire and Chaponda, Enesia Banda and Mirandola, Massimo and Chikwanda, Ephraim and Mwewa, Vivian and Mulenga, Joyce M. and Chaponda, Mike and Ghilardi, Ludovica and Harding-Esch, Emma M. and Smith, Chris and Matsui, Mitsuaki and Chandramohan, Daniel and Schröder, Daniel and Golparian, Daniel and Ali, Mohamed Mahmoud and Blondeel, Karel and Unemo, Magnus and Toskin, Igor and Chico, R. Matthew}, year = {2025}, journal = {BMC Infectious Diseases}, volume = {24}, number = {Suppl 1}, doi = {10.1186/s12879-025-10698-9}, url = {1946277}, language = {eng}, publisher = {University of Chicago Press}, keywords = {trichomonas vaginalis; antenatal care (anc); point-of-care test; pregnancy; sexually transmitted infection (sti)}, abstract = {BACKGROUND: Infection with Trichomonas vaginalis (TV) is the most prevalent curable sexually transmitted infection (STI) globally and is associated with prelabour rupture of membranes, preterm delivery, and low birthweight. Point-of-care (POC) testing for TV during pregnancy may facilitate rapid antenatal case detection and treatment. This study, part of the World Health Organization's global ProSPeRo study, aimed to evaluate the performance of OSOM® Trichomonas Rapid Test, an antigen-based POC test, against a reference nucleic acid amplification test (NAAT) among pregnant women in Zambia. We also assessed the operational characteristics and patient acceptability of the POC test, within the context of WHO's target product profiles for STI POC tests.METHODS: We enrolled pregnant women attending four health centres in Nchelenge, Zambia, for antenatal care between 15 February and 26 May 2023. Vaginal swabs for the TV POC test and a reference NAAT (Aptima® Trichomonas vaginalis assay) were obtained. POC test results were read independently by two study staff members. Study staff filled a questionnaire on the operational characteristics of the POC test, and participants were asked about their willingness to wait for results.RESULTS: Paired POC and reference test samples were collected from 1,015 participants. Overall, 23.0% (233/1015) tested positive for TV by NAAT, and 15.3% (155/1015) tested positive by the POC test, with three inconclusive results. The overall sensitivity and specificity of the POC test were 66.4% (95% confidence intervals [CI] 57.7-74.1%) and 99.6% (95% CI: 98.8-99.9%), respectively. Sensitivity was higher among those with TV-associated symptoms compared to those without (83.6% versus 60.4%, relative ratio 1.39, 95% CI 1.14-1.68). Inter-rater agreement was 99.7% (Cohen's Kappa 0.989). The study staff (n = 14) found the test easy to use and interpret, with most staff (12/14) reporting results were available within 25 min.CONCLUSION: Overall, the TV POC test showed lower sensitivity than WHO's 85% target, but exceeded the 99% specificity target. Among symptomatic pregnant women, sensitivity nearly reached the WHO target. The assay was user-friendly, required minimal training, and delivered results quickly. Further studies are needed to determine the optimal antenatal settings for this technology.TRIAL REGISTRATION: PACTR202302766902029.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alpkvisthelena_2025, title = {Diagnostic and prognostic potential of plasma and sputum thrombomodulin in bacterial community-acquired pneumonia}, author = {Alpkvist, Helena and Athlin, Simon and Norrby-Teglund, Anna and Stralin, Kristoffer}, year = {2025}, journal = {Infectious Diseases}, volume = {57}, number = {11}, pages = {1078--1087}, doi = {10.1080/23744235.2025.2528957}, url = {1986415}, language = {eng}, publisher = {Taylor & Francis}, keywords = {thrombomodulin; community-acquired pneumonia; streptococcus pneumoniae; severe cap; biomarker}, abstract = {Background: Soluble thrombomodulin, a marker of endothelial cell injury, is released into the circulation during endothelial damage and has been observed at elevated concentrations in bacterial infections. This study aimed to investigate the correlation of thrombomodulin concentrations in plasma and sputum with disease severity and etiology in bacterial community-acquired pneumonia (CAP).Methods: A prospective study was conducted on adults hospitalized with radiologically confirmed bacterial CAP. Plasma and sputum samples were collected upon admission, and thrombomodulin concentrations were quantified using an enzyme-linked immunosorbent assay. The study included a multivariate analysis to assess whether thrombomodulin concentrations were associated with disease severity and/or bacterial etiology.Results: Of 111 patients with bacterial CAP, including 15 with severe CAP (as defined by the American Thoracic Society/Infectious Diseases Society of America criteria) and 63 with pneumococcal etiology, thrombomodulin was measured in plasma in all patients and in sputum in 42 patients. Elevated plasma thrombomodulin concentrations were independently associated with severe CAP. Stratification by bacterial etiology showed that higher plasma thrombomodulin concentrations were linked to severe pneumonia only in patients with pneumococcal infection. The area under the receiver operating characteristic curve for detecting severe pneumococcal CAP was 0.87. Conversely, sputum thrombomodulin concentrations showed no association with disease severity or bacterial etiology.Conclusions: Plasma thrombomodulin is a promising biomarker for identifying severe pneumococcal CAP. Sputum thrombomodulin did not correlate with disease severity or bacterial etiology. These findings support further investigation into the diagnostic and prognostic role of plasma thrombomodulin in bacterial infections.}, issn = {2374-4235} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_belaynehmeseret_2025, title = {Diagnostic comparison of microbial culture and polymerase chain reaction for the diagnosis of bacterial meningitis in a tertiary hospital, North West Ethiopia}, author = {Belayneh, Meseret and Alemu, Fikadu and Idosa, Berhane A. and Assefa, Meseret and Särndahl, Eva and Abate, Ebba and Säll, Olof and Gelaw, Baye}, year = {2025}, journal = {IJID Regions}, volume = {17}, doi = {10.1016/j.ijregi.2025.100743}, url = {2006249}, language = {eng}, publisher = {Elsevier}, keywords = {bacterial meningitis; microbiological culture; neisseria meningitidis; real-time pcr; streptococcus pneumoniae}, abstract = {BACKGROUND: Bacterial meningitis (BM) represents the most severe variant of meningitis, with a mortality rate that may reach up to 100% in the absence of appropriate treatment. The success of therapeutic interventions is depends upon prompt and precise diagnostic evaluations. However, there exists a significant deficiency in the literature regarding the diagnostic efficacy within the Ethiopian context. Consequently, this study aims to evaluate and compare the diagnostic precision of microbial culture and polymerase chain reaction (PCR) methodologies in individuals with suspected meningitis in Northwest Ethiopia.METHODS: Cerebrospinal fluid (CSF) samples were procured from 400 patients who were clinically suspected of having meningitis and were admitted to the University of Gondar Specialized Hospital (UoGSH), located in Northwest Ethiopia. Real-time PCR, microbial culture, Gram staining, and cell enumeration were conducted at both the UoGSH laboratory and the Armauer Hansen Research Institute in Addis Ababa.RESULTS: Of the total patients enrolled in the study, 58% were male. Clinical manifestations such as fever, headache, and neck stiffness were reported in 94%, 90%, and 81% of the patients, respectively, whereas altered consciousness was recorded in 37% of the cohort. The real-time PCR methodology identified 38 patients (10%) as positive for meningitis, in contrast to microbial culture, which detected only 10 (3%) of these positive cases. The two diagnostic modalities exhibited a correlation coefficient of 0.4 (p < 0.05).CONCLUSION: The traditional microbiological culture technique, in conjunction with Gram staining, was found to have a limited sensitivity in identifying bacterial meningitis compared with the real-time PCR methodology. Consequently, the integration of molecular approaches with higher sensitivity, such as real-time PCR, facilitates prompt diagnosis and precise treatment, while simultaneously sustaining the overarching meningitis surveillance framework.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alwandiahmed_2025, title = {Diagnostic Conversion From Psychotic Unipolar Depression to Bipolar and Psychotic Disorders : A Swedish Registry-Based Study}, author = {Al-Wandi, Ahmed and Landén, Mikael and Nordenskjöld, Axel}, year = {2025}, journal = {Acta Psychiatrica Scandinavica}, doi = {10.1111/acps.70059}, url = {2023947}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {diagnostic conversion; diagnostic stability; psychotic depression}, abstract = {OBJECTIVE: To estimate the cumulative incidence of diagnostic conversion from psychotic unipolar depression to bipolar and psychotic disorders in Sweden.METHODS: Data from Swedish national registers were used to identify incident cases of psychotic unipolar depression between 2005 and 2011. To minimize the risk of misclassification, patients with a prior history of psychotic disorders, bipolar disorders, or manic episodes were excluded. Patients were followed until the first occurrence of a diagnostic change, death, or December 31, 2021. The cumulative incidence of diagnostic change was estimated using a competing risk model.RESULTS: A total of 7836 patients diagnosed with psychotic depression between 2005 and 2011 were included. The median age at index diagnosis of psychotic depression was 49 years (interquartile range: 35-65), and 56.7% were women. By the end of follow-up, 28.8% (95% CI: 27.7-29.9) of patients had undergone a diagnostic change to either a psychotic or bipolar disorder. The cumulative incidence of conversion was higher to psychotic disorders (17.5%, 95% CI: 16.6-18.4) than to bipolar disorders (14.7%, 95% CI: 13.8-15.5). In a sensitivity analysis requiring at least two recorded diagnoses separated by ≥ 1 year, the overall incidence of diagnostic change decreased to 19.0% (95% CI: 18.1-20.0), with corresponding rates of 10.0% (95% CI: 9.3-10.7) to psychotic disorders and 9.8% (95% CI: 9.1-10.5) to bipolar disorders. Diagnostic conversion was more common among younger individuals.CONCLUSION: Approximately 20%-30% of patients diagnosed with psychotic depression in secondary care in Sweden are expected to receive a subsequent diagnosis of a bipolar or psychotic disorder within 17 years. This has important clinical implications, as prognosis and treatment strategies differ between these conditions. Further research is needed to identify risk factors for diagnostic conversion to improve early detection and management.}, issn = {0001-690X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_elanderjohanna_2025, title = {Diagnostic Yield and Genetic Variation in 85 Swedish Patients with Mild to Profound Hearing Loss Analyzed by Whole Genome Sequencing}, author = {Elander, Johanna and Ullmark, Tove and Löwgren, Karolina and Stenfeldt, Karin and Falkenius-Schmidt, Karolina and Löfgren, Maria and Castiglione, Alessandro and Busi, Micol and Jonson, Tord and Ivarsson, Sofie and Ehrencrona, Hans and Ehinger, Johannes K. and Värendh, Maria}, year = {2025}, journal = {Journal of Otolaryngology - Head & Neck Surgery}, volume = {54}, doi = {10.1177/19160216251345471}, url = {1988558}, language = {eng}, publisher = {Sage Publications}, keywords = {genetic hearing loss; whole genome sequencing; pathological variants; prelingual snhl; diagnostic yield}, abstract = {Importance: The genetic variation in patients with sensorineural hearing loss (SNHL) in the Nordic countries has not been previously reported.Objectives: The aim was to describe the genetic variation in a Swedish population and identify factors in favor of a high diagnostic yield.Design: This was a prospective cohort study. Children with bilateral SNHL and adults with bilateral SNHL and clinically suspected genetic SNHL underwent genetic testing. A gene panel with similar to 200 genes was applied on whole genome sequencing (WGS) data. Variants were classified according to American College of Medical Genetics and Genomics criteria. Personal health data were extracted from medical records.Setting and Participants: Eighty-five patients (aged 0-73 years) from Lund and Orebro University Hospitals, 2 tertiary referral centers for audiology in Sweden, with mild to profound SNHL.Results: In almost half (45%, n = 38) of the cases, a genetic cause was identified across 24 different genes. Eleven cases had syndromic hearing loss. A majority (n = 57) had prelingual onset (<2 years) of SNHL and most of them had moderate-to-profound hearing loss (n = 52). Prelingual onset was associated with higher yield than postlingual onset (OR 6.3, 95% CI 2.1-19.0). In patients with moderate-profound prelingual SNHL, the diagnostic yield was 60% (n = 31/52).Conclusion: This is the first reported cohort of hearing loss patients undergoing genetic testing with WGS from a Nordic country. Early onset of hearing loss favored a higher diagnostic yield than postlingual, and a genetic cause was found in a majority of cases in patients with prelingual, moderate-to-profound SNHL.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_adaszaksofie_2025, title = {Dialogue about violence with victims with cognitive disabilities : Challenges faced by professionals}, author = {Adaszak, Sofie and Gustafsson, Johanna and Holmefur, Marie and Källström, Åsa and Farias Vera, Lisette}, year = {2025}, journal = {Journal of Social Work}, volume = {25}, number = {6}, pages = {846--869}, doi = {10.1177/14680173251336092}, url = {1962354}, language = {eng}, publisher = {Sage Publications}, keywords = {disability; domestic violence; decision making; power; practice}, abstract = {Summary: Dialogues between professionals and clients in social work are central to identifying and providing support for violence in close relationships. How professionals approach dialogues about violence in close relationships with clients with cognitive disabilities, and associated challenges to making them accessible, are understudied. Semi-structured interviews with 18 professionals in disability services, domestic violence shelters, social services, and health services in Sweden were conducted. Previous findings and gaps in theory motivated an inductive content analysis which generated four categories that illustrate challenges to accessible violence in close relationship dialogues.Findings: The four categories comprise challenges about : understanding and reasoning about violence; self-determination and protection; adapting assessment tools and approaches; and urgent and long-term approaches. These challenges entail difficulties in creating shared understandings and handling conflicting rights of clients. Furthermore, they included the need to adapt and maintain the validity of assessment tools, as well as organizational restrictions on the use of long-term approaches.Applications: The findings shed light on how professionals must simultaneously handle various aspects of violence in close relationship dialogues. Verbally adhering to a given description of a situation was restricted by the need to maintain a professional-client relationship. When motivating the need to accept support, professionals had to avoid manipulating clients. Furthermore, the findings indicate several weaknesses in current practice that professionals struggle to address individually, such as, overly extensive assessment tools and little guidance on identifying less overt forms of violence in close relationships. Professional guidance is required in social work practice and related fields.}, issn = {1468-0173} } @mastersthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_adaszaksofie_2025_1, title = {Dialogues on Violence in Close Relationships : Perspectives from Professionals and Persons with Cognitive Disability}, author = {Adaszak, Sofie}, year = {2025}, url = {2018187}, language = {eng}, publisher = {Örebro University}, keywords = {dialogue; cognitive disability; violence in close relationships; ableism}, abstract = {People with disabilities have a higher risk of exposure to violence than people without disabilities. Although dialogues between professionals and clients hold potential for improving the response to violencei n close relationships against persons with cognitive disabilities (PwCD), the necessary and favorable conditions for these dialogues to have a positive effect have received little attention.Purpose: This thesis explores dialogues about violence in close relationships from the perspectives of professionals and PwCD, thus identifying the conditions needed to achieve co-constructed understanding through such dialogues by integrating scientific theory on dialogue, disability, and violence.Methods: An explorative design was applied in two studies, using qualitative methods to gain insight into perspectives from professionals and PwCD. In parallel, an abductive approach was used to construct a theoretical framework for analysis.Conclusions: This thesis emphasizes that dialogues are shaped by processes at multiple levels, extending beyond interpersonal dynamics to include ableist structures, normative expectations, and disability-related experiences of violence. Strengthening violence literacy among professionals and PwCD can improve the conditions for dialogue. To facilitate the co-construction of shared understanding in dialogue, professionals should acknowledge the dimensions of trust and powerbalance, provide access to adapted communication, supported decision-making, and enable the individual choice of communicators.       Future Research: The use of vignettes, and expansions to the proposed theoretical framework, are promising topics for future research.}, file = {https://oru.diva-portal.org/smash/get/diva2:2018187/FULLTEXT03.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_sofidana_2025, title = {Diasporans dubbla världar : Identitet, tillhörighet och hybriditet}, author = {Sofi, Dana}, year = {2025}, pages = {239--251}, url = {2011971}, language = {swe}, publisher = {Södertörns högskola}, keywords = {diaspora; identitet; tillhörighet; kulturell hybriditet} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wgerjonny_2025, title = {Didactic dimensions of teaching content for and with students with intellectual disabilities (ID) : a scoping review}, author = {Wåger, Jonny and Bagger, Anette}, year = {2025}, journal = {European Journal of Special Needs Education}, volume = {40}, number = {1}, pages = {53--68}, doi = {10.1080/08856257.2024.2323250}, url = {1848220}, language = {eng}, publisher = {Routledge}, keywords = {word; intellectual disability; teaching; review; content}, abstract = {Decisions schools make about teaching content fundamentally shape students' educational experience and their later life. These decisions often take a particular shape for students with intellectual disabilities. Although such decisions for this group are a prime concern in the governing and practice of education, they have gained little attention in research. Research that does investigate teaching content for students with intellectual disabilities often makes a distinction between Life Functional skills (LFS) and Academic Content (AC) and treats these as being quite separate. The study at hand explores the nuances of and relationship between the two through a scoping review, and contributes knowledge on didactical aspects and the how and why of teaching content as depicted in research. Results indicate that research on teaching content entails a complex process of valuing the content in which AC and LFS often overlap. Results also illustrate that students and teachers are absent from the research on teaching content and not included as active participants; researchers' methods often take precedence over teachers' and students' valuing of teaching content or methods.}, issn = {0885-6257} } @book{ca0f099bbf2a435cee8f97bef5e8cbaa_hmanjohan_2025, title = {Didaktiska modeller för miljö- och hållbarhetsutbildning}, author = {Öhman, Johan and Tryggvason, Ásgeir and Sund, Louise}, year = {2025}, url = {1929295}, language = {swe}, publisher = {Studentlitteratur AB}, keywords = {hållbar utveckling; miljöundervisning; miljö- och hållbarhetsutbildning; demokrati; undervisning}, abstract = {Miljö och hållbar utveckling hör till vår tids stora ödesfrågor, och mycket talar för att vi behöver förändra vårt samhälle och sätt att leva i grunden. Utbildningen spelar en nyckelroll i denna omställning som kräver nya kunskaper, synsätt och värderingar. Men att utbilda för förändring ställer också lärare inför nya didaktiska utmaningar. I denna bok presenteras didaktiska modeller som stödjer lärares arbete med miljö- och hållbarhetsutbildning. Modellerna utgör tankeverktyg som lärare kan använda vid val av innehåll och arbetsformer när de planerar sin undervisning. Innehållet i boken bygger på didaktisk forskning som författarna har bedrivit de senaste två decennierna, och lägger särskilt fokus på de etiska och politiska aspekterna av miljö- och hållbarhetsutbildning. Didaktiska modeller för miljö och hållbarhetsutbildning vänder sig till lärarstuderande, lärarutbildare och verksamma lärare som undervisar om miljö och hållbar utveckling på grundskolans högstadium, gymnasiet och inom högre utbildning och folkbildning.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_ebersmartin_2025, title = {Die neue Produkthaftungs-Richtlinie : Wegbereiter für Follow-on-Klagen im Recht der Künstlichen Intelligenz?}, author = {Ebers, Martin}, year = {2025}, pages = {69--109}, url = {2024588}, language = {ger}, publisher = {Nomos Verlagsgesellschaft} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hlnerik_2025_1, title = {Difference in clinical presentation and surgical outcomes in pediatric and adult patients with Chiari malformation type 1 : a single center retrospective study}, author = {Öhlén, Erik and El-Hajj, Victor Gabriel and Staartjes, Victor E. and Jabbour, Pascal and Edström, Erik and Elmi-Terander, Adrian}, year = {2025}, journal = {Acta Neurochirurgica}, volume = {167}, number = {1}, doi = {10.1007/s00701-025-06534-3}, url = {1954839}, language = {eng}, publisher = {Springer}, keywords = {chiari 1 malformation; chicago chiari outcome scale; posterior fossa decompression; syringomyelia}, abstract = {INTRODUCTION: Chiari malformation type 1 (CM1) is a common congenital disorder affecting both children and adults. Although pediatric and adult CM1 patients share many characteristics, the differences between the groups are not fully described.METHOD: A comparative analysis was made of two previously defined cohorts of adult and pediatric non-syndromic CM1, surgically treated at the study center. Clinical outcomes were assessed using the Chicago Chiari outcome scale (CCOS) and radiological outcomes were measured as change in cerebellar tonsil and syringomyelia status.RESULTS: A total of 209 patients (73 pediatric, 136 adults) were included, with median ages of 11 and 33 years, respectively. The proportion of female patients (62% vs 78%) was higher in the adult population (p = 0.012). Headache (p = 0.007), neck pain (p = 0.000), vertigo (p = 0.007), and sensory symptoms (p = 0.000) were more common in adults, while scoliosis (p = 0.000) and sleep apnea (p = 0.015) were more common in the pediatric population. Preoperative imaging findings did not differ significantly. After posterior fossa decompression, both groups scored a median CCOS of 15 at early follow-up (3 vs 4 months), though the pediatric population had a more favorable distribution of CCOS scores (p = 0.003). Postoperatively, syringomyelia status did not differ significantly between groups, but cerebellar tonsil status improved more frequently in adults (64% vs 88%, p = 0.000).CONCLUSION: This study demonstrates that while headache is the most common presenting symptom in both pediatric and adult CM1 patients, pediatric patients are more likely to present with scoliosis and sleep apnea. In contrast adult patients more frequently experience headache, neck pain, vertigo, and sensory symptoms. There were no differences in other preoperative imaging variables and outcomes were favorable for most patients in both groups.}, issn = {0001-6268} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_venturinimarco_2025, title = {Differential Area Analysis for Ransomware : Attacks, Countermeasures, and Limitations}, author = {Venturini, Marco and Freda, Francesco and Miotto, Emanuele and Conti, Mauro and Giaretta, Alberto}, year = {2025}, journal = {IEEE Transactions on Dependable and Secure Computing}, volume = {22}, number = {4}, pages = {3449--3464}, doi = {10.1109/tdsc.2025.3532324}, url = {1960095}, language = {eng}, publisher = {IEEE}, keywords = {ransomware detection; entropy; differential area analysis; vulnerabilities; invasive software}, abstract = {Crypto-ransomware attacks have been a growing threat over the last few years. The goal of every ransomware strain is encrypting user data, such that attackers can later demand users a ransom for unlocking their data. To maximise their earning chances, attackers equip their ransomware with strong encryption which produce files with high entropy values. Davies et al. proposed Differential Area Analysis (DAA), a technique that analyses files headers to differentiate compressed, regularly encrypted, and ransomware-encrypted files. In this paper, first we propose three different attacks to perform malicious header manipulation and bypass DAA detection. Then, we propose three countermeasures, namely 2-Fragments (2F), 3-Fragments (3F), and 4-Fragments (4F), which can be applied equally against each of the three attacks we propose. We conduct a number of experiments to analyse the ability of our countermeasures to detect ransomware-encrypted files, whether implementing our proposed attacks or not. Last, we test the robustness of our own countermeasures by analysing the performance, in terms of files per second analysed and resilience to extensive injection of low-entropy data. Our results show that our detection countermeasures are viable and deployable alternatives to DAA.}, issn = {1545-5971} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_beaudeauj_2025, title = {Differential expression of enteric glial cell markers in inflamed and non-inflamed tissue of patients with Ulcerative Colitis during clinically active disease and remission}, author = {Beaudeau, J. and Katinios, G. and Biskou, O. and Lindqvist, C. M. and Walter, S. A. and Bednarska, O. and Söderholm, J. D. and Salomon, Benita and Halfvarson, Jonas and Schoultz, Ida and Hjortswang, H. and Keita, Å. V.}, year = {2025}, journal = {Journal of Crohn's & Colitis}, volume = {19}, number = {Suppl. 1}, pages = {I567--I567}, doi = {10.1093/ecco-jcc/jjae190.0342}, url = {1938318}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background: Ulcerative colitis (UC), a major subtype of inflammatory bowel disease, is characterized by chronic inflammation of the colon and rectum. Enteric glial cells (EGC) play a crucial role in gut barrier maintenance and may contribute to UC pathophysiology. This study aims to investigate EGC and their associated proteins in patients during clinically active disease and in clinical remission following anti-inflammatory treatment.Methods: Colonic or rectal biopsies were obtained at baseline from both inflamed and non-inflamed segments in 14 patients with clinically active UC initiating anti-inflammatory therapy and from the same segments when the patients were in clinical and endoscopic remission during follow-up. As control groups, colonic biopsies from 16 patients with irritable bowel syndrome (IBS)-Mixed and 16 healthy controls were included. Immunofluorescence staining assessed two EGC markers: the glial fibrillary acidic protein (GFAP+) and S100 calcium-binding protein B (S100β+). Relative estimates of inflammatory proteins in biopsies were analysed using Olink technology, In vitro, the EGC cell line CRL-2690 was exposed to interleukins (IL)-4, IL-6, and IL-18 at varying concentrations and durations, with GFAP expression analysed by western blot.Results: In patients with UC, immunofluorescence analysis revealed significantly higher GFAP+ and S100β+ EGC counts in inflamed biopsies during active disease compared to macroscopically non-inflamed biopsies obtained during clinical and endoscopic remission. Compared to baseline biopsies from macroscopically non-inflamed mucosa, GFAP expression significantly decreased during follow-up (Figure 1), while S100β levels remained unaltered. Regardless of mucosal inflammatory status, patients with UC exhibited higher EGC counts than IBS-mixed patients and healthy controls. Our findings also showed a significant upregulation of EGC-associated pro-inflammatory proteins, such as IL-6, IL-8 and TNF in inflamed biopsies from patients with clinically active UC, compared to biopsies obtained when the patients were in remission as well as to healthy controls. Notably, these protein levels decreased during inactive UC, approaching levels observed in the healthy controls. In vitro, IL-6 upregulated GFAP expression dose- and time-dependently, while IL-4 and IL-18 induced expression in a less predictable pattern.Conclusion: Elevated EGC counts, and pro-inflammatory proteins characterise inflamed mucosa in UC during clinical active disease highlighting their potential roles in UC related inflammation. These findings may suggest that EGC could be explored as a potential therapeutic target and may contribute to the discovery of novel biomarkers for disease monitoring.}, issn = {1873-9946} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_eldeenalkhadraaizz_2025, title = {Differential Outcomes in Colorectal Cancer Detection : A Comparative Study of Swedish Nationwide Screening and Fast-Track Diagnostic Pathways}, author = {El Deen Alkhadraa, Izz and Uebel, Linnea and Kromodikoro, Indy and van Nieuwenhoven, Michiel A}, year = {2025}, journal = {Journal of Clinical Gastroenterology}, volume = {59}, number = {6}, pages = {576--581}, doi = {10.1097/MCG.0000000000002073}, url = {1893999}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, keywords = {colorectal cancer; screening; colonoscopy; fast-track; fit; adenoma; polyps; adenoma detection rate}, abstract = {BACKGROUND: In 2021, a nation-wide screening program for colorectal cancer (CRC) was step-wise implemented in Region Örebro County (RÖC) for patients aged 60 to 74 years, utilizing the fecal immunochemical test (FIT) to refer patients for colonoscopy. Concurrently, the standardized care course for colorectal cancer (SCC-CRC), initiated in 2016, employs a fast-track pathway for patients with alarm symptoms to undergo colonoscopy. This study compares CRC screening colonoscopies with SCC-CRC colonoscopies in RÖC among patients aged 60 to 67 years.METHODS: An initial analysis of the Swedish colorectal screening cohort was combined with a retrospective cohort study, analyzing data from 307 CRC screening patients and 441 age-matched SCC-CRC patients in RÖC. Data included demographics, colonoscopy participation rates, and pathology findings. Statistical analyses compared outcomes between the 2 groups.RESULTS: Among the screening group, 2% tested positive for FIT, with an 86% colonoscopy participation rate (N=9296). In RÖC, 266 screening patients underwent colonoscopy, with 10% diagnosed with CRC, compared with 20% in the SCC-CRC group. In addition, 39% of the screening group in RÖC were diagnosed with advanced adenomas, versus 15% in the SCC-CRC group.CONCLUSIONS: Screening participation was high, with effectiveness aligning with international counterparts. The SCC-CRC pathway excels in diagnosing CRC among symptomatic patients, while the nationwide screening program is effective in early detection of CRC and advanced adenomas. underscoring the importance of integrating and optimizing both approaches within the Swedish health care system to optimize CRC prevention and management.}, issn = {0192-0790} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_lewisruth_2025, title = {Digital gender-sexual violations and social marketing campaigns}, author = {Lewis, Ruth and Hearn, Jeff and Hall, Matthew}, year = {2025}, pages = {190--198}, doi = {10.1007/978-3-031-56681-3_133}, url = {1998315}, language = {eng}, publisher = {Palgrave Macmillan}, keywords = {social marketing; violence; digitalisation; violations}, abstract = {This entry addresses sexuality education about the intersection of sexuality and gendered violence, with a focus on men’s violence against women which is the dominant pattern of interpersonal violence. The field of anti-violence work by both activists and official agents (such as criminal justice systems, education systems, and public health) is vast. Here we are concerned with two aspects: anti-violence work conducted via social marketing campaigns, as a form of public education; and the growing problem of digital gender-sexual violations (DGSV) (Hall et al., 2023). DGSV refers to the use, typically but not only, by men and boys of digital technologies to perpetrate gender-based violence (GBV) and so violate known and/or unknown victim-survivors, typically, but not only, women and girls. DGSV has major negative effects on the health, well-being and freedom of victim-survivors, and accordingly, we use the same term ‘perpetrators’ for those who perpetrate DGSV, as is used for those who perpetrate offline physical, sexual and related violences. DGSV amongst lesbian, gay and bisexual people is also a significant issue (see Dietzel, 2021) that warrants further examination but is beyond the remit of this paper. }, file = {https://oru.diva-portal.org/smash/get/diva2:1998315/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_qandeelmais_2025_1, title = {Digital oppression and cyber surveillance in Palestine}, author = {Qandeel, Mais and Cristiano, Fabio and AbuArqoub, Omar and Topak, Özgün}, year = {2025}, url = {1940941}, language = {eng}, keywords = {digital rights; cyber surveillance; palestine; digital oppression}, abstract = {Departing from the notion of “cyber surveillance” in relation to control and settler colonialism - building on Elia Zureik's work, this session will highlight the main issues pertaining to the status of Palestinians under Israeli cyber surveillance and digital oppression, given the latest Israeli genocidal conduct in the Palestinian Territory. In doing so, this session will discuss the use of AI-enhanced systems to track Palestinians, systematizing massive surveillance and automating harsh restrictions to their rights and freedoms.Additionally, the session will explore the role of social media platforms in facilitating cyber surveillance that has led to genocidal surveillant assemblage. The discussion will connect this conduct to resistance and cybersecurity issues. This session, finally, will explore the legality of such conduct under the applicable rules and norms of international law. The session brings together experts in the field to show how AI-enhanced surveillance is being deployed and misused in Palestine, whether through social media platforms, extensive physical presence of CCTV cameras, or the use of AI-enhanced systems, such as, automated drones and facial recognition technology.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hanhongdan_2025, title = {Digital transformation impacts organisational change in the role of accountants and auditors : an exploratory study}, author = {Han, Hongdan and Sammour, Ammar and Gao, Shang and Yamoah, Fred A. A.}, year = {2025}, journal = {Journal of Organizational Change Management}, doi = {10.1108/JOCM-03-2025-0288}, url = {2002916}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {accounting professionals; digital transformation; blockchain technology; future work}, abstract = {Purpose: This study explores the impact of artificial intelligence (AI) on accounting and auditing professionals as businesses navigate digital transformation.Design/methodology/approach: A qualitative research approach was adopted, analysing data from 10 podcasts and 17 semi-structured interviews using NVivo software. Key themes were identified to provide insights into AI's influence on organisational change in accounting practices.Findings: The research constructs a thematic framework comprising three aggregate dimensions: triggers of digital transformation in accounting practices, opportunities and challenges in transforming accounting practices, and changing routines for accounting professionals. The results are further interpreted using Lewin's 3-Step Model of Organisational Change to comprehend the impact of AI and understand how accountants can adapt to these technological changes to sustain their practices.Originality/value: This study provides a good understanding of the social shifts towards utilising AI in increasingly automating accounting tasks, reshaping professional roles and creating both opportunities and challenges. AI enhances efficiency in bookkeeping, reporting, auditing and risk analysis but also raises concerns about data integrity and trust. Blockchain technology emerges as a potential solution, enhancing transparency, security and reliability in AI-enabled accounting systems. To remain relevant, accounting professionals must bridge digital skill gaps and adopt interdisciplinary collaboration. As AI continues to evolve, blockchain integration could reinforce trust and accountability, shaping the future of accounting and auditing.}, issn = {0953-4814} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_shawketfadi_2025, title = {Dimethyl fumarate treatment in multiple sclerosis is associated with a decrease in serum glial fibrillary acidic protein Results from the RIFUND-MS trial}, author = {Shawket, Fadi and Lycke, Jan and Salzer, Jonatan and Piehl, Fredrik and Fink, Katharina and Mellergård, Johan and Malmeström, Clas and Sundström, Peter and Lange, Niclas and Erngren, Ida and Al-Grety, Asma and Kultima, Kim and Freyhult, Eva and Burman, Joachim and Svenningsson, Anders}, year = {2025}, journal = {Multiple Sclerosis Journal}, volume = {31}, number = {Suppl. 3}, pages = {697--698}, url = {2037967}, language = {eng}, publisher = {Sage Publications}, abstract = {Introduction: Serum neurofilament light (sNfL) and serum glial fibrillary acidic protein (sGFAP) are considered to reflect axonal damage associated to acute inflammation and astrogliosis involved in disease biology of progression in multiple sclerosis (MS), respectively. While most disease-modifying drugs (DMDs) reduce sNfL levels, the effect of different DMDs on sGFAP remains limited.Objectives/Aims: To compare the impact of rituximab (RTX) and dimethyl fumarate (DMF) on levels of sNfL and sGFAP in a randomized clinical trial setting.Methods: The RIFUND-MS trial (NCT02746744) was a rater-blinded randomized phase 3 trial comparing DMF and RTX regarding prevention of relapses over 2 years in a largely treatment naive cohort of people with relapsing-remitting multiple sclerosis (RRMS). Serum for biomarker analyses was collected on four occasions: months 0, 6, 12 and 24. Concentrations of NfL and GFAP were analyzed using single molecular array (SIMOA) assay (Quanterix 2-PLEX). Separate analyses were done for intention to treat (ITT), per protocol (PP) and switch populations.Results: A total of 200 individuals were randomized 1:1 to RTX or DMF, of which 197 were available for analyses. In the ITT group, sNFL decreased from baseline to month 24 by approximately 50% in the RTX arm (p=3.1e-10), and by 46% in the DMF arm (p=3.6e-10), however without significant differences between the treatment arms in any of the group comparisons (global p-value for treatment effect in ITT=0.065; PP=0.083; switch group=0.15). In contrast, sGFAP levels significantly decreased by approximately 13.5% (p=3.7e-5) during DMF treatment, with no change observed in the RTX arm (p=0.83). Global p-values for treatment effect in favor of DMF were ITT=0.018; PP=0.0040; switch group=0.74.Conclusion: We have previously shown that RTX is superior to DMF in reducing relapse rate and lesion formation on MRI. This difference was not reflected in changes in sNfL levels, as RTX and DMF reduced sNfL to the same extent over a 2-year treatment period. Interestingly, however, exposure to DMF, but not RTX, was also associated with a significant decrease of sGFAP levels, possibly indicating an effect on pathological processes involved in progression that are independent of inflammatory activity.}, issn = {1352-4585} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_larssonmatz_2025, title = {Direct Effects of Bipedalism on Early Hominin Fetuses Stimulated Later Musical and Linguistic Evolution}, author = {Larsson, Matz and Falk, Dean}, year = {2025}, journal = {Current Anthropology}, volume = {66}, number = {2}, pages = {257--278}, doi = {10.1086/734554}, url = {1944823}, language = {eng}, publisher = {University of Chicago Press}, abstract = {We hypothesize that auditory and motor entrainment evolved in early hominin fetuses in direct response to their mothers' bipedal footsteps and, later, contributed to the evolution of music and language via two related processes. First, selection for bipedalism transformed feet from grasping into weight-bearing organs, which negatively affected infants' ability to cling to their mothers, provoking the emergence of novel affective vocal exchanges between mothers and infants that became building blocks for the emergence of motherese. Second, the derived ability to entrain movements to sound was incorporated during the prehistoric emergence of wide-ranging rhythmic behaviors such as synchronized chanting of nonlexical vocables and coordinated rhythmic clapping and stomping, which became instrumental during the more recent evolution of music. Like the derived ability to keep beat with rhythmic sounds, nascent motherese entailed entrainment of motor behavior (the physical production of pitch, timing, and vocalization rate) with external sources of sound (conversational utterances). If motherese was a precursor for language evolution, as many believe, music and language share phylogenetically derived substrates for auditory and motor entrainment that stemmed directly from bipedalism. If so, bipedalism was more important for serendipitously sculpting advanced cognition in our prehistoric ancestors than previously believed.}, issn = {0011-3204} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_sdergrenjonatan_2025_1, title = {Disability and Digital Marketing}, author = {Södergren, Jonatan and Vallström, Niklas}, year = {2025}, doi = {10.4324/9781032691664}, url = {1958144}, language = {eng}, publisher = {Routledge}, abstract = {This book explores how digital marketing can drive disability inclusion in consumer culture by addressing accessibility, representation, and research methodologies. It offers practical and theoretical insights for academics, practitioners, and policymakers interested in marketing, communication, sociology, and public policy.The first part, Digital Marketplace Accessibility, examines strategies for reducing the digital divide, including inclusive hiring practices and accessible platform development. The second part, Digital Representation, focuses on how people with disabilities are portrayed in digital media. It analyses topics such as aesthetics, influencer marketing, mental health advocacy, and neurodiversity. The third part, Digital Methodologies, highlights research approaches like netnography and offers reflections on methodological challenges when researching consumers with disabilities. Contributors discuss practices for conducting ethical and inclusive research involving people with disabilities, providing a roadmap for scholars. The final part, Poetic Epilogue, takes a poetic turn, offering an ecopoetic reflection on lived experiences of Alzheimer’s disease.This book encourages readers to reconsider disability as a complex and intersectional category. It inspires marketers, researchers, and advocates to adopt more inclusive and socially conscious marketing practices, ultimately contributing to a more equitable digital consumer culture.  } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kroonsa_2025, title = {Disability representation in the ITV crime drama Midsomer Murders : A balance between audience acceptance and alienation}, author = {Kroon, Åsa}, year = {2025}, journal = {Critical Studies in Television}, doi = {10.1177/17496020251412258}, url = {2025626}, language = {eng}, publisher = {Sage Publications}, keywords = {disability representations; diversity; media culture; midsomer murders; social issues; television crime drama}, abstract = {This study explores disability representation in the transnational television crime drama Midsomer Murders(1997-present). It focuses on Lana who has a partial right arm and how she is positioned as a central figure in the Christmas 2023 episode. The analysis reveals a complex and contradictory pattern of interwoven ableist and anti-ableist ideas. Even though negative stereotypes are avoided, Lana’s portrayal is simultaneously visually and emotionally conditioned to avoid alienating audiences. The study speaks to critical scholars across disciplines with a broad interest in the fictional television crime drama and its abilities to communicate social (diversity) issues.}, issn = {1749-6020}, file = {https://oru.diva-portal.org/smash/get/diva2:2025626/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_olssonsofia_2025, title = {Disaster medicine in Swedish undergraduate medical education : analysing current programs and future integration in the six-year curriculum}, author = {Olsson, Sofia and Kurland, Lisa and Taube, Fabian and Björås, Joakim and Robinson, Yohan}, year = {2025}, journal = {BMC Medical Education}, volume = {25}, number = {1}, doi = {10.1186/s12909-025-07324-2}, url = {1959572}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {curriculum development; disaster medicine; disaster preparedness; medical programs; swedish medical education}, abstract = {BACKGROUND: Disaster medicine involves managing situations where medical needs exceed available resources. In Sweden, disaster medicine is not yet a mandatory component of the medical education. Since the introduction of a revised six-year medical curriculum in 2021, it is unclear how disaster medicine will be integrated into the new program. This study aimed to evaluate the status of undergraduate disaster medicine education in Swedish medical schools, the teaching methodologies employed, plans for future curriculum integration, and the extent of variation across universities. METHODS: We conducted a comprehensive review of syllabi from all Swedish medical programs to identify the inclusion of disaster medicine. Additionally, semi-structured interviews were conducted with 13 representatives from all seven Swedish medical schools, including those responsible for disaster medicine education or members of the education boards. The interviews explored teaching methods, curriculum content, and plans for the new six-year program. Data were analysed using qualitative content analysis.RESULTS: Disaster medicine is included in the curriculum of all Swedish medical programs; however, its content, extent, and teaching approaches vary. Lectures are the most common teaching method, with some schools incorporating case discussions, tabletop exercises, and disaster simulations. Most medical faculties plan to maintain or expand their disaster medicine curriculum. However, there is no formal collaboration between universities in developing or standardizing disaster medicine education for the new curriculum.CONCLUSION: The current level of disaster medicine education in Swedish medical schools requires enhancement in both quality and scope. Variations between universities would need to be minimized to ensure a more consistent approach. Preliminary plans for the new six-year medical program suggest that disparities between universities may persist, underscoring the need for a coordinated effort in standardizing disaster medicine education at the undergraduate level.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_goswamirudrap_2025, title = {Discordance in Patient and Physician's Perception of Disease Activity Among Idiopathic Inflammatory Myopathy Patients : Insights From the COVAD Study}, author = {Goswami, Rudra P. and Sen, Parikshit and Fazal, Zoha Zahid and Parihar, Jasmine and Singh, Yogesh Preet and Naveen, R. and Lilleker, James B. and Joshi, Mrudula and Agarwal, Vishwesh and Nune, Arvind and Dey, Mrinalini and Day, Jessica and Makol, Ashima and Milchert, Marcin and Gheita, Tamer and Salim, Babur and Velikova, Tsvetelina and Gracia-Ramos, Abraham Edgar and Parodis, Ioannis and Nikiphorou, Elena and Chatterjee, Tulika and Kardes, Sinan and Tan, Ai Lyn and Saavedra, Miguel A. and Shinjo, Samuel Katsuyuki and Ziade, Nelly and Knitza, Johannes and Kuwana, Masataka and Cavagna, Lorenzo and Distler, Oliver and Sarkar, Manali and Agarwal, Vikas and Gupta, Latika}, year = {2025}, journal = {International journal of rheumatic diseases}, volume = {28}, number = {10}, doi = {10.1111/1756-185X.70428}, url = {2005991}, language = {eng}, publisher = {John Wiley & Sons}, issn = {1756-1841} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_delanayepierre_2025, title = {Discordant Results Between Creatinine- and Cystatin C-based Equations for Estimating GFR}, author = {Delanaye, Pierre and Flamant, Martin and Vidal-Petiot, Emmanuelle and Björk, Jonas and Nyman, Ulf and Grubb, Anders and Bakker, Stephan J. L. and de Borst, Martin H. and van Londen, Marco and Derain-Dubourg, Laurence and Rule, Andrew D. and Eriksen, Björn O. and Melsom, Toralf and Sundin, Per-Ola and Ebert, Natalie and Schaeffner, Elke and Hansson, Magnus and Littmann, Karin and Larsson, Anders and Stehlé, Thomas and Cavalier, Etienne and Bukabau, Justine B. and Sumaili, Ernest K. and Yayo, Eric and Mariat, Christophe and Moranne, Olivier and Christensson, Anders and Lanot, Antoine and Pottel, Hans}, year = {2025}, journal = {Kidney International Reports}, volume = {10}, number = {4}, pages = {1248--1259}, doi = {10.1016/j.ekir.2025.01.030}, url = {1954917}, language = {eng}, publisher = {Elsevier}, keywords = {creatinine; cystatin c; glomerular filtration rate}, abstract = {Introduction: Discordant results between cystatin C and creatinine in estimating glomerular filtration rate (GFR) are an important medical issue. However, the equation that should be used when GFR estimates are discordant remains unclear.Methods: This cross-sectional analysis included 15,485 participants with GFR measured by the clearance of an exogenous marker, serum creatinine, and cystatin C. We studied the proportion of discordant results defined as an absolute (> 15 ml/min per 1.73 m(2)) or relative (> 20%) difference between creatinine-based estimated GFR (eGFR, eGFR(crea)) and cystatin C-based eGFR (eGFR(cys)) using different equations (Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI], European Kidney Function Consortium [EKFC], and reexpressed Lund-Malm & ouml; [r-LMR]). We also researched for the best estimating equations to be used in subjects with concordant or discordant results to estimate measured GFR (mGFR).Results: In the total cohort, the proportion of subjects with discordant results (absolute or relative) was larger for CKD-EPI (35.1 and 40.6%) than for EKFC (21.9 and 31.7%) or r-LMR (22.8 and 32.8%) equations. Among discrepant results, the proportion of eGFR(cys) < eGFR(crea) was significantly higher than the proportion of eGFR(crea) < eGFR(cys) for the CKD-EPI equations, whereas the occurrence of discrepancy was similar in the 2 discrepant groups for EKFC or r-LMR. For the EKFC and r-LMR equations, but not for the CKD-EPI, the equation combining creatinine and cystatin C was consistently the closest to the mGFR in the discrepant groups.Conclusion: Based on the lower discrepancy proportion, better balance between eGFR(crea) and eGFR(cys), and better concordance with mGFR, the EKFC, and r-LMR equations should be preferred over the CKD-EPI to estimate GFR.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kiesedominik_2025, title = {Discrete Lehmann representation of three-point functions}, author = {Kiese, Dominik and Strand, Hugo U. R. and Chen, Kun and Wentzell, Nils and Parcollet, Olivier and Kaye, Jason}, year = {2025}, journal = {Physical Review B}, volume = {111}, number = {3}, doi = {10.1103/PhysRevB.111.035135}, url = {1938697}, language = {eng}, publisher = {American Physical Society}, abstract = {We present a generalization of the discrete Lehmann representation (DLR) to three-point correlation and vertex functions in imaginary time and Matsubara frequency. The representation takes the form of a linear combination of judiciously chosen exponentials in imaginary time, and products of simple poles in Matsubara frequency, which are universal for a given temperature and energy cutoff. We present a systematic algorithm to generate compact sampling grids, from which the coefficients of such an expansion can be obtained by solving a linear system. We show that the explicit form of the representation can be used to evaluate diagrammatic expressions involving infinite Matsubara sums, such as polarization functions or self-energies, with controllable, high-order accuracy. This collection of techniques establishes a framework through which methods involving three-point objects can be implemented robustly, with a substantially reduced computational cost and memory footprint.}, issn = {2469-9950} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wewermd_2025, title = {Disease course of inflammatory bowel disease unclassified during the first ten years following diagnosis : A prospective European population-based inception cohort - the Epi-IBD cohort}, author = {Wewer, M. D. and Lophaven, S. and Lakatos, P. L. and Gonczi, L. and Salupere, R. and Kievit, H. A. L. and Nielsen, K. R. and Midjord, J. and Domislovic, V and Krznaric, Z. and Pedersen, N. and Kjeldsen, J. and Halfvarson, Jonas and Sebastian, S. and Goldis, A. and Arebi, N. and Oksanen, P. and Neuman, A. and Andersen, V and Katsanos, K. H. and Koukoudis, A. and Turcan, S. and Ellul, P. and Kupcinskas, J. and Kiudelis, G. and Fumery, M. and Kaimakliotis, I. P. and D'Inca, R. and Lombardini, S. and Hernandez, V and Fernandez, A. and Langholz, E. and Munkholm, P. and Burisch, J.}, year = {2025}, journal = {Journal of Crohn's & Colitis}, volume = {19}, number = {Suppl. 1}, pages = {i2278--i2279}, doi = {10.1093/ecco-jcc/jjae190.1432}, url = {1936078}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background: The Epi-IBD cohort is a prospective European population-based cohort of 1,508 patients diagnosed in 2010 and 2011 with inflammatory bowel disease (IBD) according to Copenhagen criteria in centres across 17 European countries. The study aims to describe treatment strategies, disease course and prognosis of IBD unclassified (IBDU) across Europe.Methods: Patients with IBDU were defined as not fulfilling the Copenhagen diagnostic criteria of Crohn’s disease (CD) or ulcerative colitis (UC), but still required IBD related treatment and monitoring. They were followed prospectively from the time of diagnosis until December 31st, 2020, death, emigration or loss of follow-up. Clinical data on surgery, hospitalizations, and medical treatment were captured throughout the follow-up period and entered into a validated web-database, www.epi-ibd.org. Patients with IBDU were categorised as CD-like, UC-like or mixed CD-UC based on disease location and continuity of the affected bowel segments at diagnosis.Results: In total, 129 IBDU patients aged ≥15 years from 22 centres were included. They comprised 8.5% (N=129/1,508) of the total cohort. The disease location was reported in Table 1 where 4 patients had unknown disease location at baseline. At diagnosis, 16% (N=25/129) were CD-like, 52% (N=62/129) were UC-like and 32% (N=42/129) were mixed CD-UC.During the 10-year follow-up, 32% (N=41/129) were re-classified as either CD (N=16) or UC (N=25). The crude 1-, 5-, and 10-year rates for re-classification of diagnosis were 19%, 26% and 32%. The time to initiation of therapies and the distribution of therapies according to re-classification of IBDU diagnosis at baseline are presented in Figure 1 A-B . Advanced therapies were used in 13% (N=17/129) of patients over the 10-year follow-up, and was initiated after a median period of 1.9 years (inter-quartile range 0.9-8.1). An intestinal resection was required in 7% (N=9/129). After 1, 5, and 10 years, 9%, 19% and 26% of the patients diagnosed with IBDU at baseline, respectively, required hospitalisation.Conclusion: After 10 years of follow-up, a third of patients initially diagnosed with IBDU were re-classified as either CD or UC. The disease course was in general mild with a low number of patients requiring advanced therapy, intestinal resection, and hospitalization. However, patients who were re-classified as CD or UC were more frequently treated with medical therapies.}, issn = {1873-9946} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_granathannika_2025, title = {Disease impact on health-related quality of life, anxiety, and depression, in antineutrophil cytoplasmic antibody-associated vasculitis : A cluster analysis approach}, author = {Granath, Annika and Brolin, S. and Dahlberg, Karuna and Gunnarsson, I. and Welin, Elisabet and Pettersson, S.}, year = {2025}, journal = {Scandinavian Journal of Rheumatology}, volume = {54}, number = {Suppl. 132}, pages = {274--275}, url = {2016253}, language = {eng}, publisher = {Taylor & Francis}, abstract = {Background: Antineutrophil cytoplasmic antibody associated vasculitis (AAV), which includes Granulomatosis with Polyangiitis (GPA), Microscopic Polyangiitis (MPA), and Eosinophilic Granulomatosis with Polyangiitis (EGPA) are diseases which can cause patients to experience impaired Health-Related Quality of Life (HRQoL), higher levels of anxiety, depression, and fatigue throughout life. The aim of this study was to explore patient reported HRQoL, anxiety, depression, and fatigue among persons with AAV from different perspectives; Compare levels of HRQoL, anxiety, depression, fatigue and disease characteristics; Describe associations between disease characteristics and HRQoL, anxiety, depression and fatigue; Explore clusters of HRQoL, anxiety and depression.Methods: This cross-sectional cohort study included adults with new and established diagnosis of AAV. Anxiety and depression were assessed with Hospital Anxiety and Depression Score, e.g., HADS anxiety (HADS-A), and HADS-depression (HADS-D). HRQoL was assessed with EQ-5D-3L (EQ-5D-index), EQ-Visual analogue scale (EQ-VAS), fatigue by Multidimensional assessment of Fatigue (MAF). Disease activity was measured by Birmingham Vasculitis Activity Score (BVAS), and scores ≥ 1 was defined as active disease. Disease duration ≤ 2 years was considered short disease duration. Mann-Whitney U-test and Kruskal Wallis H-test was used where appropriate to compare distributions between groups of patients. Bivariate correlations were analysed with Spearman’s rank-order correlation. A hierarchical cluster analysis was performed, based on EQ-5D-index, EQ-VAS, HADS-A and HADS-D.Results: 296 patients were included, equally distributed between women; 157 (53%) and men; 139 (57%), with a median age of 63 years (range: 18–90, IQR: 50–70). Two hundred and nine had GPA (70,6%), 75 had MPA (25,3%), and twelve had EGPA (4,1%). Their median BVAS score was 1 (range: 0–33, IQR: 0–12), and 46% had an inactive disease. Median disease duration was 2 years (range: 0–31, IQR: 0–6), and 55% had a disease duration of ≤ 2 years. The median current dose of prednisolone was 5 mg (range: 0–80, IQR: 0–12.5).HRQoL, measured with EQ-VAS, was higher in patients < 65 years old, those with inactive disease, and those with long disease duration (≥3 years) (p = 0.005–0.017), while EQ-5D-3L only varied with disease activity (p = 0.014). Women, patients with active disease, and patients with shorter disease duration reported more anxiety (p = 0.001–0.03), and younger persons with active disease and short disease duration reported more fatigue (p = 0.002–0.03).In the total group, disease activity and disease duration were both associated with HRQoL, anxiety, depression, and fatigue (rs -0.279 – 0.286). Among patients with EGPA, a moderate association (rs -0.736) between disease activity and EQ-5D-index, moderate association (rs 0.579) between disease duration and EQ-VAS, and a moderate association (rs -0.699) between disease duration and MAF was observed.Four clusters based on EQ-5D index, EQ-VAS, and HADS were identified, containing patients with various levels of HRQoL and psychological distress across the disease course. The four clusters were denoted A-D. A: Low HRQoL, mild anxiety/depression, high disease activity and short disease duration. B: High HRQoL, no anxiety/depression, no disease activity and long disease duration. C: Moderate HRQoL, mild anxiety/depression, low disease activity and short disease duration. D: Moderate to high HRQoL, no anxiety/depression, no disease activity and longer disease duration. The four clusters had similar distributions between women, men, and age, and the three diagnoses were represented in each of the four clusters and were distinctive separated by EQ-VAS.Conclusion: The impact of AAV on HRQoL, anxiety, depression, and fatigue, is persistent and varies depending on disease activity, disease duration, gender, and age. Associations between disease activity, disease duration and HRQOL, anxiety, depression, and fatigue were present in all diagnostic subgroups of AAV. Four clusters revealed the ongoing impact of AAV, emphasizing the continuous need for multiprofessional support during the disease course. In this study, EQ-VAS was better able to effectively distinguish levels of HRQoL than EQ-5D-index.}, issn = {0300-9742} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hoffjrgensencamilla_2025, title = {Disgust, Pleasure, and Convenience in fast-food consumption : Perspectives from Danish Middle-Class Parents}, author = {Hoff-Jørgensen, Camilla and Leer, Jonatan}, year = {2025}, journal = {Appetite}, volume = {207}, doi = {10.1016/j.appet.2025.107858}, url = {1932844}, language = {eng}, publisher = {Elsevier}, keywords = {chefs’ burgers; denmark; fast food chain; middle-class}, abstract = {Family meals are an important topic in food consumption research linked to health, care, morality, etc. Recent consumer surveys show that home cooking and family eating patterns are under pressure due to increasingly busy everyday family lives. Here, fast food meals offer a practical solution. However, several studies in the Danish context (and in other geographical areas) highlight a strong moral ideal among middle-class families to produce healthy and home-cooked meals, which should render fast food illegitimate. This study builds on these studies on food, moralities, and parenting, and the purpose is to explore Danish middle-class parents' attitudes about going to multinational fast-food chains and how they navigate dilemmas around practical and moral issues. Additionally, we explore how new, seemingly more exclusive food products at a multinational fast-food chain in Denmark impact parents' views. Semi-structured interviews were conducted with n = 17 Danish middle-class parents who had been to a multinational fast-food chain in 2021 as a new series of "quality" burgers designed by Michelin chefs was introduced. Our findings show that all participants demonstrated some degree of moral concern about fast-food consumption. These concerns result in strong, affective narratives of disgust and compensation strategies for the most troubled. More particularly, we argue that the consumption of fast food is (1) closely embedded in family rituals, and (2) it entails a meal negotiation between children's pleasure and adults' disgust (particularly mothers' disgust) for most participants. Finally, (3) we highlight that the availability of 'novel' products more closely aligned with Danish middle-class ideals and aspirations around food, like the fine dining chefs, Chefs' Burgers (CB), make those disputes easier for most parents. Others react negatively to the campaign.}, issn = {0195-6663} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ohaganlaurenalex_2025, title = {Dishpan hands, class anxiety and the performance of femininity : marketing Maniol hand cream in early 20th-century Sweden}, author = {O’Hagan, Lauren Alex}, year = {2025}, journal = {Journal of Historical Research in Marketing}, doi = {10.1108/JHRM-05-2025-0026}, url = {2029099}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {maniol; advertisements; dishpan hands; class anxiety; femininity}, abstract = {Purpose: This study aims to examine how sociocultural changes in early 20th-century Sweden, particularly regarding the roles and expectations of women, gave rise to class anxieties and specific performances of femininity. Specifically, it examines how these tensions were constructed and mobilised through the marketing of Maniol hand cream.Design/methodology/approach: Using multimodal critical discourse analysis, this study examines Maniol's print advertisements from 1920 to 1940, focusing on how linguistic, visual and other semiotic resources were used to navigate and respond to evolving social norms and gender expectations.Findings: Three key themes emerge: the burden of respectable domesticity; the performance of professional femininity; and hands as a marker of feminine attractiveness. It shows how advertisements constructed both domestic labour and professional life as threats to femininity - threats that could be concealed or corrected through consumption. They also underscored the social risks of neglecting one's hands in terms of female civic responsibilities as workers, mothers and wives, arguing that true femininity required hands untouched by visible labour. In doing so, the brand articulated broader anxieties around gender performance, class mobility and the visibility of domestic work in a society undergoing profound transformations in labour, gender roles and social expectations. At the same time, these discourses reinforced whiteness as the normative standard of beauty, positioning racialised bodies as outside the normative boundaries of modern femininity.Originality/value: This study uniquely foregrounds the cultural and symbolic significance of women's hands in early 20th-century Swedish marketing, revealing how Maniol hand cream advertisements became a focal point for negotiating class anxieties, femininity and social respectability. Focusing on class - a vital but often overlooked aspect of Swedish marketing history - this paper provides a fresh and critical examination of how marketing strategies in early 20th-century Sweden shaped and reflected class relations and gender dynamics. It, thus, emphasises the importance of situating advertising discourse within its broader sociohistorical context, showing how marketing both mirrors and actively shapes cultural anxieties, ideals and social hierarchies, while also reinforcing whiteness as the embodied norm of beauty and respectability.}, issn = {1755-750X} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrkvallanders_2025_1, title = {Diskurser om hållbar stadsutveckling : En analys av Slakthusområdet i Stockholm}, author = {Björkvall, Anders}, year = {2025}, volume = {39}, pages = {11--32}, doi = {10.15626/svebe39.01}, url = {2007267}, language = {swe}, publisher = {Institutionen för svenska språket, Linnéuniversitetet}, keywords = {slakthusområdet; hållbar stadsutveckling; svenska språket; diskurser om hållbarhet; sociala praktiker; indexikalitet; semiotiska landskapsstudier; ekolingvistik; geosemiotik}, abstract = {Denna artikel handlar om hur hållbar stadsutveckling kommuniceras om och på en specifik plats: Slakthusområdet, en del av stadsutvecklingsområdet Söderstaden i södra Stockholm. Syftet är att identifiera vilka diskurser – kunskap ur ett visst perspektiv om hållbarhet – som finns närvarande i texter om omvandlingen av Slakthusområdet och att se om dessa finns närvarande i sociala praktiker – vad som har gjorts eller ska göras – som pekas ut (eller indexeras) i Slakthusområdet. Till syftet knyts två frågor: Vilka diskurser om hållbarhet är mest framskjutna i centrala strategi- och stadsplaneringstexter om Slakthusområdet? Vilka, om några, av de identifierade hållbarhetsdiskurserna ansluter de indexerade sociala praktikerna i området till? Den sista forskningsfrågan handlar alltså om att det som pekas ut som möjligt att göra för människor – eller vad som redan har gjorts – kan vara grundade i olika perspektiv på, eller diskurser om, hållbarhet. Med en grund i fälten språkliga och semiotiska landskapsstudier och ekolingvistik analyseras texter som detaljplaner och arkitekturprogram samt bilder från en fältstudie i Slakthusområdet utifrån begreppen diskurs, indexikalitet och social praktik. Resultaten visar att triaden social, ekonomisk och ekologisk hållbarhet återfinns som diskurser i texterna, liksom hur ett arkitektur-perspektiv är tydligt en fysiskt-estetisk hållbarhetsdiskurs där hållbarhet konstrueras som byggnadsmaterialens fysiska hållbarhet samt som hur väl arkitekturens estetik står sig över tid. Fältstudien visade att främst ekonomiska och arkitektoniska praktiker indexerades: att konsumera, men att göra det i miljöer som anknyter till tidigare praktiker i Slakthusområdet. Intressant nog fanns ingen tydlig indexering av ekologiska hållbarhetspraktiker – som de flesta kanske uppfattar som kärnan i hållbar stadsutveckling.}, file = {https://oru.diva-portal.org/smash/get/diva2:2007267/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_smithcarolina_2025, title = {Disproportionately raised risk of adverse outcomes in patients with COPD and comorbid type 2 diabetes or depression : Swedish register-based cohort study}, author = {Smith, Carolina and Hasselgren, Mikael and Sandelowsky, Hanna and Ställberg, Björn and Hiyoshi, Ayako and Montgomery, Scott}, year = {2025}, journal = {Respiratory Research}, volume = {26}, number = {1}, doi = {10.1186/s12931-025-03160-6}, url = {1942986}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {copd; cardiovascular disease; depression; mortality; type 2 diabetes}, abstract = {BACKGROUND: We aimed to examine if patients with COPD and comorbid type 2 diabetes, or COPD with comorbid depression or anxiety, had disproportionally raised excess risks of subsequent cardiovascular disease and mortality.METHODS: This general population-based cohort study used data from Swedish national registers, with follow-up during 2005-2018. Cox regression estimated risks of cardiovascular disease or mortality, producing hazard ratios (HR) with (95% confidence intervals). Interaction testing quantified disproportionally increased excess risks.RESULTS: Among 5,624,306 individuals, 332,549 had a COPD diagnosis. Compared with individuals who did not have COPD or type 2 diabetes, all-cause mortality risk was higher for individuals who had either COPD or type 2 diabetes, with HR 2.68 (2.66-2.69) and 1.70 (1.69-1.71), respectively. Having both conditions produced an HR of 3.72 (3.68-3.76). Among cardiovascular outcomes, the highest risks were found for chronic heart failure: COPD only, HR 2.87 (2.84-2.90); type 2 diabetes only, 1.86 (1.84-1.88); and both, 4.55 (4.46-4.64). Having both COPD and type 2 diabetes was associated with disproportionally higher excess risks than expected from the sum of the individual diseases, except for cerebrovascular disease or ischemic heart disease. For COPD and depression/anxiety, all-cause mortality risk was associated with COPD only, HR 2.74 (2.72-2.76); depression/anxiety only, 2.39 (2.38-2.40); and both 4.72 (4.68-4.75). Chronic heart failure was associated with COPD only, HR 2.74 (2.71-2.78); depression/anxiety only, 1.31 (1.30-1.32); and both, 3.45 (3.40-3.50). This disease combination was associated with disproportionally higher excess risks than expected, except for atrial fibrillation.CONCLUSIONS: Type 2 diabetes or depression/anxiety in COPD patients were associated with disproportionally excess risks for cardiovascular disease and mortality. It is important for clinicians to be aware of these greater than expected risks, to prevent further cardiovascular morbidity and mortality.}, issn = {1465-9921} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_jonssonjessica_2025_1, title = {Disrupted Identity Rights of Adoptees : A Commentary}, author = {Jonsson, Jessica}, year = {2025}, pages = {119--141}, url = {1993572}, language = {eng}, publisher = {Iustus förlag}, abstract = {This article critically examines the legal dimensions of identity rights foradopted children, with particular emphasis on the right to birth identification,registration, and access to original birth certificates. It explores howthese rights are frequently compromised, especially in contexts involvingstatelessness, displacement, or cross-border adoption, and assesses the profoundimplications for the child’s legal identity. Drawing on international legalinstruments, notably the United Nations Convention on the Rights of theChild (CRC) and its General Comments, the article highlights the persistentfailure of states to ensure effective implementation of identity rights protections.It argues that the absence of accurate and accessible birth registrationmechanisms not only undermines a child’s identity but also perpetuates legalinvisibility, hinders access to remedies, and exacerbates the marginalizationof vulnerable populations.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_archerarlene_2025, title = {Disrupting Academic Publishing : Peer Review and Negotiations of New Genre Systems}, author = {Archer, Arlene and Björkvall, Anders}, year = {2025}, pages = {727--747}, doi = {10.1007/978-3-031-80322-2_26}, url = {2009417}, language = {eng}, publisher = {Palgrave Macmillan}, keywords = {alternative genres; decoloniality of knowledge-making; disruption; epistemic democracy; global-centric scholarship}, abstract = {Some academic journals question the position of the research article as the only format of publication. This chapter looks at the challenges and potentials of publishing alternative genres to the research article in peer reviewed journals. In doing so, we illuminate the underlying assumptions and norms in academic publishing. We specifically focus on the peer review process of a ‘practitioner reflection’ genre and the ways in which this genre is negotiated between authors and reviewers. Peer review in higher education is often enmeshed with power, authority, and hierarchy as it assumes an authoritative expert and depends on critique within a competitive framework. Feminist and decolonial scholars have increasingly argued the need to rethink some of these practices as traditional peer reviewing can be seen to be rooted in (west) Eurocentric normative practices of knowledge production. As illustrations of our thinking, we present an analysis of three manuscripts and their related reviews: a reflection by a design practitioner; a reflection on pedagogic practice in the form of a comic; and an artist’s autoethnographic reflection. We argue that in academic publishing, we need to ‘disrupt’ established forms in order to push the boundaries of research genres. This can go some way towards the decolonization of knowledge-making systems in academia. }, file = {https://oru.diva-portal.org/smash/get/diva2:2009417/FULLTEXT01.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_haschenina_2025, title = {Disruptions in sustainability-led business endeavours}, author = {Hasche, Nina and Salmi, Asta}, year = {2025}, pages = {36--51}, doi = {10.4324/9781003599548-5}, url = {2015728}, language = {eng}, publisher = {Routledge} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_casemegan_2025, title = {Distance Students of Less Commonly Taught Languages and Their Personal Learning Environments}, author = {Case, Megan}, year = {2025}, url = {1953805}, language = {eng}, publisher = {Örebro University}, keywords = {distance education; higher education; less commonly taught languages; personal learning environments; activity theory; computerassisted language learning; digital tools}, abstract = {This dissertation is an exploration of conditions that afford and constrain how adults undertake activities connected with learning less commonly taught languages (LCTLs), which are languages other than English, Spanish, French, and German. The overarching aim of this dissertation is to describe how different factors in the environments of adults learning LCTLs affect the ways that those learners engage with the target languages over time. The intended contribution of this dissertation is to provide insights to help educational policymakers, institutions, teachers, and learners make choices that better support the goal of plurilingualism. Among the findings of the four studies that comprise the empirical portion of this dissertation is the idea that learners actively and strategically choose a wide variety of tools for their personal learning environments, some of which afford new ways of conducting language learning operations. Digital tools do not replace the work of language learning but create opportunities to do the work in different ways. There is no single learning or teaching method that is best for all learners, and learners should always keep looking for different types of tools, human relationships, and courses that can help them meet their language learning goals. In a digital landscape with many opportunities for self-study, teachers continue to be valued for providing explanations, structure, benchmarks and feedback. The findings also indicate the importance of the availability of distance education for LCTLs. The personal learning environments of adult learners of LCTLs depend on the kinds of tools, communities, and institutions available to them, and reducing structural barriers to different kinds of adult education is crucial to achieving national and international goals for plurilingualism.}, file = {https://oru.diva-portal.org/smash/get/diva2:1953805/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_garantziotispanagiotis_2025, title = {DISTINCT MOLECULAR PROFILES OF REMISSION POST-CD19 CAR-T CELL THERAPY VERSUS STANDARD IMMUNOSUPPRESSION IN SYSTEMIC LUPUS ERYTHEMATOSUS}, author = {Garantziotis, Panagiotis and Beretta, Lorenzo and Lindblom, Julius and Nikolopoulos, Dionysis and Bertsias, George and Hagen, Melanie and Taubmann, Jule and Wirsching, Andreas and Bozec, Aline and Grieshaber-Bouyer, Ricardo and Schneider, Matthias and Barturen, Guillermo and Boumpas, Dimitrios and Alarcón-Riquelme, Marta and Schett, Georg and Parodis, Ioannis}, year = {2025}, journal = {Journal of Rheumatology}, volume = {52}, number = {Suppl. 1}, pages = {8--8}, doi = {10.3899/jrheum.2025-0390.O006}, url = {2014492}, language = {eng}, publisher = {The Journal of Rheumatology}, issn = {0315-162X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_garantziotisp_2025, title = {DISTINCT MOLECULAR RESPONSES TO CD19 CAR-T CELL THERAPY VERSUS STANDARD PHARMACOTHERAPY IN SYSTEMIC LUPUS ERYTHEMATOSUS}, author = {Garantziotis, P. and Beretta, L. and Lindblom, J. and Nikolopoulos, D. and Grieshaber-Bouyer, R. and Moysidou, G. S. and Hagen, M. and Wirsching, A. and Taubmann, J. and Bergmann, C. and Bozec, A. and Barturen, G. and Fanouriakis, A. and Bertsias, G. K. and Schneider, M. and Boumpas, D. and Alarcon-Riquelme, M. and Schett, G. and Parodis, Ioannis}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {84}, number = {Suppl. 1}, pages = {2177--2177}, url = {1988541}, language = {eng}, publisher = {Elsevier}, keywords = {epitranscriptomics; epigenetics; and genetics; omics}, abstract = {Objectives: Early trials of CD19-chimeric antigen receptor (CAR) T cell therapy in systemic lupus erythematosus (SLE) show promise, but the molecular mechanisms underlying its disease-modifying effects remain unclear. We aimed to compare biological profiles and alterations following CD19-CAR T cell versus standard pharmacotherapy in SLE.Methods: Pseudo-bulk gene expression derived from single-cell RNA sequencing of peripheral blood mononuclear cells from 7 SLE patients before and after CD19-CAR T cell therapy was compared with whole-blood transcriptome data from 30 SLE patients in remission on standard pharmacotherapy and 31 SLE patients before and 6 months after treatment with rituximab, belimumab, or cyclophosphamide. Pathway analysis was conducted using Functional Analysis of Individual Microarray Expression and gene set enrichment analysis.Results: CD19-CAR T cell-induced remission was characterised by marked suppression of complement activation, type I interferon, DNA damage response (DDR), and cell death pathways compared with remission following conventional pharmacotherapy, alongside an upregulation of lipid metabolism pathways. Compared with rituximab and belimumab, CD19-CAR T cell therapy induced greater downregulation of type I/II interferon, DDR, and chemokine pathways. Compared with cyclophosphamide, CD19-CAR T cell therapy induced greater suppression of interferon, mitochondrial, and mammalian target of rapamycin signalling pathways.Conclusions: CD19-CAR T cell therapy induces substantial suppression of key immunological pathways involved in SLE, including complement activation and type I interferon responses, accompanied by a metabolic reprogramming. Molecular profiles of remission after CD19-CAR T cell therapy differ from those induced by conventional SLE pharmacotherapy, suggesting more profound CD19-CAR T cell-induced biological alterations.}, issn = {0003-4967} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kalidindisaisushanthvarma_2025, title = {District heating optimization in residential buildings using reinforcement learning with adaptive context-aware predictive environment}, author = {Kalidindi, Sai Sushanth Varma and Banaee, Hadi and Karlsson, Hans and Loutfi, Amy}, year = {2025}, journal = {Energy and AI}, volume = {22}, doi = {10.1016/j.egyai.2025.100603}, url = {2002865}, language = {eng}, publisher = {Elsevier}, keywords = {residential buildings; adaptive context-aware transformer; district heating; energy optimization; reinforcement learning (rl)}, abstract = {As district heating networks evolve to meet climate-neutral objectives, optimizing their control under heterogeneous building characteristics and dynamic environmental conditions remains a significant challenge. Traditional control strategies often lack the adaptability necessary to account for building-specific dynamics and to ensure real-time adherence to operational safety constraints. In this work, we present an integrated machine learning-based framework that combines an adaptive context-aware transformer model with deep reinforcement learning to address these limitations. The proposed approach introduces an adaptive context-aware transformer as a predictive environment within a Deep Q-Network (DQN) framework, enabling data-driven, building-specific control of district heating systems. Utilizing real-world data from 148 residential buildings across Sweden and Finland, the model incorporates contextual embeddings and temporal features to predict indoor temperature trajectories with high accuracy, achieving root mean square error values between 0.18-0.24 degrees C for Swedish buildings and 0.26-0.32 degrees C for Finnish buildings. The DQN agent leverages these predictions to optimize heating control while ensuring compliance with operational safety limits and preserving occupant comfort. Experimental results demonstrate significant energy savings, with mid-rise buildings achieving up to 14.85% reduction in energy consumption, and peak seasonal savings exceeding 20% during spring months. This integrated approach illustrates the potential for substantial energy optimization and reliable indoor climate management in future district heating networks.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bazsefidpaynikoo_2025, title = {Does antibiotic prophylaxis have an effect on postoperative infection in temporomandibular joint surgery? : A systematic review}, author = {Bazsefidpay, Nikoo and Ulmner, Mattias and Friman, Erik and Lund, Bodil}, year = {2025}, journal = {Journal of Cranio-Maxillofacial Surgery}, volume = {53}, number = {7}, pages = {938--945}, doi = {10.1016/j.jcms.2025.03.002}, url = {1946415}, language = {eng}, publisher = {Churchill Livingstone}, keywords = {antibiotic; oral and maxillofacial surgery; surgical outcome; surgical site infection; tmj surgery; temporomandibular joint}, abstract = {There is ongoing debate about the necessity of antibiotic prophylaxis regarding temporomandibular joint (TMJ) surgery. With antibiotic resistance being a major concern and challenge, developing solid recommendations on antibiotic use is essential to prevent overuse, misuse, and to enhance patient safety. The aim of this systematic review (SR) was to evaluate the scientific evidence regarding the effectiveness of antibiotics in preventing postoperative infections following TMJ surgery. Comprehensive literature searches were conducted using The Cochrane Library, Medline, EMBASE, and Web of Science. The selection process was based on predefined criteria, followed by a quality assessment of the retrieved SRs and primary studies using ROBIS and GRADE, respectively. Out of 8976 studies identified, 20 were reviewed in full text, and two were included in this SR for a risk of bias assessment. The quality assessment revealed a generally high risk of bias. In conclusion, no evidence-based recommendation can currently be made regarding antibiotic usage in relation to TMJ surgery. There is a knowledge gap concerning the impact of antibiotics on postoperative infection in TMJ surgeries, underscoring the need for further research in this field.}, issn = {1010-5182} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_chesneyedward_2025, title = {Does cannabidiol reduce the adverse effects of cannabis in schizophrenia? A randomised, double-blind, cross-over trial}, author = {Chesney, Edward and Oliver, Dominic and Sarma, Ananya and Lamper, Ayşe Doğa and Slimani, Ikram and Lloyd, Millie and Dickens, Alex M. and Welds, Michael and Kråkström, Matilda and Gasparini-Andre, Irma and Oresic, Matej and Lawn, Will and Babayeva, Natavan and Freeman, Tom P. and Englund, Amir and Strang, John and McGuire, Philip}, year = {2025}, journal = {Neuropsychopharmacology}, volume = {50}, number = {12}, pages = {1759--1767}, doi = {10.1038/s41386-025-02175-3}, url = {1988537}, language = {eng}, publisher = {Springer Nature}, abstract = {In patients with schizophrenia, cannabis use exacerbates symptoms and can lead to a relapse of psychosis. Some experimental studies in healthy volunteers suggest that pre-treatment with cannabidiol (CBD) may reduce these effects, but others do not. Here, we investigated whether pre-treatment with CBD ameliorates the acute adverse effects of cannabis in patients with schizophrenia. Participants (n = 30) had schizophrenia or schizoaffective disorder plus a comorbid cannabis use disorder. In a double-blind, randomised, placebo-controlled, crossover trial, participants received oral CBD 1000 mg or placebo three hours before inhaling vaporised cannabis (containing Delta 9-tetrahydrocannabinol (THC) 20-60 mg). The primary outcome was delayed verbal recall measured with the Hopkins Verbal Learning Test-Revised. We also measured psychotic symptoms with the Positive and Negative Syndrome Scale (PANSS) - positive subscale. Delayed verbal recall after cannabis administration was 3.5 words (95% confidence interval [CI]: 2.5-4.5) following pre-treatment with CBD, compared to 4.8 words (95% CI: 3.9 to 5.8) following pre-treatment with placebo (mean difference [MD] = -1.3 [95% CI: -2.0 to -0.6]; p = 0.001). After CBD pre-treatment, inhalation of cannabis was associated with an increase in PANSS-P score of 5.0 (95% CI: 3.6 to 6.5), compared to 2.9 (95% CI: 1.5 to 4.3) following pre-treatment with placebo (MD = 2.2 [95% CI: 0.6 to 3.7]; p = 0.01). Administration of CBD did not have a significant effect on plasma concentration of THC or its active metabolite, 11-hydroxy-THC. In patients with schizophrenia and a comorbid cannabis use disorder, pre-treatment with CBD did not attenuate the acute effects of cannabis on memory impairment or psychotic symptoms, but appeared to exacerbate them. The study was registered on Clinicaltrials.gov (NCT04605393).}, issn = {0893-133X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_larssonjohannes_2025, title = {Does deliberate practice surpass didactic training in learning empathy skills? A randomized controlled study}, author = {Larsson, Johannes and Werthén, David and Carlsson, Jan and Salim, Osame and Davidsson, Edvin and Vaz, Alexandre and Sousa, Daniel and Norberg, Joakim}, year = {2025}, journal = {Nordic Psychology}, volume = {77}, number = {1}, pages = {39--52}, doi = {10.1080/19012276.2023.2247572}, url = {1807229}, language = {eng}, publisher = {Taylor & Francis Group}, keywords = {deliberate practice; empathy; randomized controlled trial; repeated measures; therapeutic skills}, abstract = {A large body of research identifies therapist expressed empathy as one of the most important predictors of psychotherapy outcome. Deliberate practice (DP) is an effective method to improve skills in many fields. We asked if DP also can be used to enhance the skill of expressing empathy.Objective: The aim was to compare the efficacy of DP to didactical learning methods (DLM) in enhancing the skill of empathic expression in students.Method: A repeated measures randomized controlled group design was used. Novice students (N = 36) from psychologist-, medicine-, social work-, and nursing programs received two training sessions of either DP (n = 21) or DLM (n = 15). Participants' skills in empathic expression were assessed with the Measure of Expressed Empathy (MEE) on three occasions: before the first, between, and after the last training session.Results: Participants in the DP-group showed improved empathic expression, whereas participants in the DLM-group did not.Conclusions: These findings suggest that DP is an effective training method for therapeutic skills such as empathic expression and holds implications for the future development of educational practices to incorporate active skill training methods.}, issn = {1901-2276} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gomezmicaelak_2025, title = {Does pediatric trauma center designation matter for children in shock from gunshot wounds? A Trauma Quality Improvement Program analysis}, author = {Gomez, Micaela K. and Wood, Elizabeth C. and Forssten, Maximilian Peter and Williams, Timothy K. and Forssten, Sebastian Peter and Sarani, Babak and Mohseni, Shahin and Neff, Lucas P.}, year = {2025}, journal = {Journal of Trauma and Acute Care Surgery}, volume = {99}, number = {3}, pages = {426--432}, doi = {10.1097/TA.0000000000004637}, url = {1967850}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, keywords = {gunshot wound; outcome; penetrating; trauma center}, abstract = {BACKGROUND: Recent studies have demonstrated improved outcomes for severely injured pediatric trauma patients treated at pediatric trauma centers (PTCs). Nonetheless, specific injury patterns requiring immediate lifesaving intervention may offset the recognized benefits of PTC over adult trauma centers (ATCs). This study aims to compare the clinical outcomes of hypotensive pediatric trauma patients with gunshot wounds (GSWs), based on trauma center type. We hypothesize that outcomes are equivalent for this clinical scenario.METHODS: The 2013-2021 Trauma Quality Improvement Program data set was used to identify all hypotensive pediatric patients (15 years or younger) with GSWs. Hypotension was defined per Pediatric Advanced Life Support Guidelines. Patients with an Abbreviated Injury Scale score of 6 in any region and transferred patients were excluded. In order to identify the association between PTC verification status and outcomes, Poisson regression models with robust standard errors were used.RESULTS: A total of 687 patients met the criteria for analysis, and 236 (34%) cases were treated at PTCs. Pediatric trauma center patients were slightly younger (lower quartile, 10 vs. 12 years old; p = 0.037). There was no significant difference in Injury Severity Score or crude mortality rates (68.1% vs. 70.8%, p = 0.524). After adjusting for confounders, Poisson regression showed no reduction in in-hospital mortality, complications, failure to rescue, intensive care unit admission, or mechanical ventilation rates at PTCs compared with ATCs.CONCLUSION: Gunshot wounds in children pose unique clinical challenges. Majority of cases are cared for at ATCs. Analysis of best available data did not demonstrate a benefit to managing these patients at a PTC. Conversely, ATCs were not superior, despite managing this scenario in both adults and children more often. These findings underscore the importance of ATCs in the care of this particular injury pattern and call attention to the recent pediatric readiness requirements for American College of Surgeons (ACS)-verified trauma centers to treat pediatric firearm injuries at both PTCs and ATC.LEVEL OF EVIDENCE: Therapeutic/Care Management; Level III.}, issn = {2163-0755} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dehlaghijadidkaveh_2025, title = {Does socioeconomic status influence the choice of surgical technique in abdominal rectal cancer surgery?}, author = {Dehlaghi Jadid, Kaveh and Gadan, Soran and Wallin, Göran and Nordenvall, Caroline and Boman, Sol Erika and Myrberg, Ida Hed and Matthiessen, Peter}, year = {2025}, journal = {Colorectal Disease}, volume = {27}, number = {5}, doi = {10.1111/codi.70111}, url = {1959272}, language = {eng}, publisher = {Blackwell Publishing}, keywords = {mis; laparoscopy; rectal cancer; socioeconomy}, abstract = {AIM: This study aimed to estimate the impact of socioeconomic status on the probability of receiving open (OPEN) or minimally invasive surgery (MIS) for curative abdominal rectal cancer resection.METHODS: All patients diagnosed with rectal cancer clinical Stage I-III during the period 2010-2021 who underwent curative abdominal resection surgery, MIS or OPEN, were included. Patients were identified in the Colorectal Cancer Database, a register-linkage based on the Swedish Colorectal Cancer Register and linked to several national Swedish health-related and demographic registers. Socioeconomic factors, sex, patient and tumour characteristics, number of previous surgical procedures and category of hospital were collected. Exposures were level of education (categorized as 6-9, 10-12, >12 years), household income (quartiles 1-4) and country of birth (Sweden, Nordic countries outside Sweden, Europe outside the Nordic countries, outside Europe), and outcome was MIS or OPEN. Multivariable logistic regression models were fitted for each exposure, adjusted for age, sex, cT and cN, level of tumour, and number of previous abdominal surgical procedures.RESULTS: A total of 13 778 patients were included of whom 43.6% underwent MIS (n = 6007) and 56.4% OPEN (n = 7771). Highest level of education (OR for highest vs. lowest level of education 1.15; 95% CI 1.03-1.29) and highest household income quartile (OR for highest vs. lowest household income quartile 1.27; 95% CI 1.12-1.44) increased the likelihood of receiving MIS.CONCLUSION: Despite the tax-financed healthcare system in Sweden, rectal cancer patients with the highest level of education and the highest household income had an increased probability of receiving MIS.}, issn = {1462-8910} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johnelsjakobsberg_2025, title = {Does the family situation impact academic achievement differently in students with versus without neurodevelopmental disorders?}, author = {Johnels, Jakob Åsberg and Kuja-Halkola, Ralf and Larsson, Henrik and Chang, Zheng and Brikell, Isabel and Lundström, Sebastian}, year = {2025}, journal = {British Journal of Educational Psychology}, doi = {10.1111/bjep.70050}, url = {2017575}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {assessment; primary/elementary schools; special education – atypical development}, abstract = {BACKGROUND: Youth with neurodevelopmental disorders are at risk for school failure, but little is known about the contextual factors influencing academic achievement.AIMS: Drawing on a bioecological system framework, we examined how ADHD and autism, parental educational attainment and aspects of the parent-child relationship influence educational achievement at the end of primary school, and to what extent these factors have independent as opposed to interactive effects on educational achievement. SAMPLE: A total of 12,477 twins born 1994-2005 from Sweden.METHODS: ADHD and autism were assessed at age nine with a structured telephone interview with parents. Among participants, n = 996 and n = 249 met screening criteria for ADHD and autism, respectively. At age 15, data on parent-child relationships and parental educational attainment were gathered. Children's school grades and eligibility for upper secondary school were obtained from a register, and used as main outcome measures. Multiple regression models with interaction terms were used to explore if the effects of family-related factors differed in students with or without ADHD or autism.RESULTS: ADHD or autism was associated with low academic achievement, as were all the family-related variables in multiple regression models (all p < .005). However, there was no statistical evidence (all p > .005) that the influence of family-related variables differed (i.e., were either less or more important in the prediction of educational achievement) in students with or without ADHD or autism.CONCLUSIONS: Results were in keeping with a bioecological model of non-interacting multiple risks for educational underachievement in students with ADHD and/or autism.}, issn = {0007-0998} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_murphyjasonp_2025, title = {Does the "state of disaster" response have a downside? Hospital incident command group leaders' experiences of a terrorist-induced major incident : a qualitative study}, author = {Murphy, Jason P. and Hörberg, Anna and Rådestad Rn, Monica and Kurland, Lisa and Jirwe, Maria}, year = {2025}, journal = {BMC Emergency Medicine}, volume = {25}, number = {1}, doi = {10.1186/s12873-025-01173-4}, url = {1935146}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {decision-making; disaster medicine; disaster preparedness; hospital incident command; major incident}, abstract = {AIM: This study explores HICGs' experience of disaster response during a terrorist-induced major incident major incident.DESIGN: A qualitative descriptive design with individual semi-structured interviews was used.METHODS: This was a qualitative study based on seven individual interviews. Participants were members of hospital incident command groups during a terror attack. The interviews were transcribed verbatim and analyzed using deductive content analysis. The SRQR checklist was used to report the findings.RESULTS: The data created from the interviews identified barriers and facilitators for hospital response as well as aligned with previously established categories: Expectations, prior experience, and uncertainty affect hospital incident command group response during a Major Incident and three categories, (I) Gaining situational awareness (containing two subcategories), (II) Transitioning to management (containing three subcategories) and (III) Experiences of hospital incident command group response (containing two subcategories). In addition, the results suggest that an exaggerated response may have led to unanticipated adverse events.CLINICAL TRIAL NUMBER: Not applicable.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_neelakantansuraj_2025, title = {Domain-Aware Tabular Data Augmentation Using Large Language Models}, author = {Neelakantan, Suraj and Längkvist, Martin and Loutfi, Amy}, year = {2025}, url = {2030804}, language = {eng}, abstract = {Traditional tabular augmentation methods, such as SMOTE and Gaussian sampling, treat features as generic vectors, disregarding the domain-specific constraints often present in scientific tabular data. This work introduces a domain-aware augmentation approach that leverages Large Language Models (LLMs) to encode scientific knowledge through policy generation. The effectiveness of this approach is demonstrated using a case study on geochemical compositions, where data must satisfy closure constraints and exhibit intrinsic correlations that geometric interpolation methods fail to preserve. Evaluated on an imbalanced geochemical rock classification dataset, the LLM-based augmentation achieves 95.74% accuracy and a 0.9544 macro-F1 score, outperforming SMOTE, Gaussian sampling, and no-augmentation baselines while requiring fewer synthetic samples.}, file = {https://oru.diva-portal.org/smash/get/diva2:2030804/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_blackwelltimothy_2025, title = {Dreaming of efficient markets? Residential construction, competition & affordability in the Swedish housing sector}, author = {Blackwell, Timothy and Holgersen, Ståle and Wallstam, Maria}, year = {2025}, journal = {Housing Studies}, volume = {40}, number = {1}, pages = {46--69}, doi = {10.1080/02673037.2023.2256257}, url = {1802079}, language = {eng}, publisher = {Routledge}, keywords = {housing; residential construction; competition; political economy; land; sweden}, abstract = {This paper problematises the perception that enhanced competition within the Swedish residential construction sector offers a panacea to rising building costs and deteriorating housing affordability. The paper investigates the relationships between housing production, exchange, and consumption from three perspectives: (i) an historical analysis of the residential construction industry; (ii) elite semi-structured interviews with stakeholders, and (iii) an exploration of state crisis management. Instead of viewing competition within the construction sector as an isolated sphere, we argue that the inherent unevenness within this sector needs to be grasped in combination with broader political-economic developments. We claim that rising productions costs (particularly in the tenant-owner sector) have been fuelled by soaring land prices, and that this situation has provided fertile terrain for rent-seeking throughout the housing supply chain. We conclude that calls for more competition, both in Sweden and further afield, tend to oversimplify the complex issue of housing provision and shroud more fundamental housing system imbalances.}, issn = {0267-3037} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_andrndaniela_2025_3, title = {Driver Height and Its Negative Externalities on Fatal Traffic Crashes}, author = {Andrén, Daniela}, year = {2025}, url = {2003698}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_singhjagmeetp_2025, title = {Dronedarone vs Sotalol Among Patients With Atrial Fibrillation : A Meta-Analysis of Retrospective Observational Databases}, author = {Singh, Jagmeet P. and Wieloch, Mattias and Reynolds, Shannon L. and Blomström-Lundqvist, Carina and Sandhu, Alex T. and Camm, A. John and Kabadi, Shaum and Pundi, Krishna and Turakhia, Mintu P. and Boiron, Rania and Din, Natasha and Fan, Jun and Heller, Caroline G. and Leeming, Reno C. and McKindley, David S. and Sajedian, Renee M. and Kowey, Peter R.}, year = {2025}, journal = {JACC: Clinical Electrophysiology}, volume = {11}, number = {7}, pages = {1531--1542}, doi = {10.1016/j.jacep.2025.02.029}, url = {1954852}, language = {eng}, publisher = {Elsevier}, keywords = {antiarrhythmic drugs; atrial fibrillation; dronedarone; meta-analysis; safety; sotalol}, abstract = {BACKGROUND: Dronedarone and sotalol are antiarrhythmic drugs (AADs) recommended in similar populations per atrial fibrillation (AF) guidelines; however, comparative safety data are limited.OBJECTIVES: The goal of this study was to assess the safety of dronedarone vs sotalol for treatment of AF in AAD-naive patients.METHODS: This was a prespecified noninterventional meta-analysis of 4 retrospective observational cohort studies from 4 databases (Optum Clinformatics Data Mart, Merative MarketScan, Veterans Health Administration Electronic Health Record, and the Swedish National Patient Register) conducted by using one master protocol. Each analysis emulated the target trial using an active comparator (dronedarone vs sotalol), new user design with an as-treated approach. Primary outcomes were tested hierarchically for dronedarone vs sotalol: first for statistical significance of cardiovascular (CV) hospitalization, and then for statistical significance of ventricular arrhythmias. Propensity score matching (PSM) was used for confounding control, and negative control outcomes were used to assess residual confounding. Outcomes were evaluated by using Cox proportional hazards regression; meta-analysis was performed by using fixed effects models.RESULTS: The dronedarone and sotalol cohorts were well balanced within databases before and after PSM (after PSM mean age range: 62.5-70.9 years; mean CHA2DS2-VASc score range: 1.81-3.15). Negative control outcomes exhibited little-to-no evidence of residual confounding. Meta-analysis found significantly lower rates of CV hospitalization (pooled HR: 0.91; 95% CI: 0.85-0.97) and ventricular arrhythmias (pooled HR: 0.77; 95% CI: 0.69-0.85) with dronedarone vs sotalol.CONCLUSIONS: In this retrospective meta-analysis, dronedarone exhibited significantly lower rates of CV hospitalization and ventricular arrhythmias compared with sotalol. These findings provide real-world evidence to support selection of the most appropriate first-line AAD for rhythm control in patients with AF.}, issn = {2405-500X} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_neelakantansuraj_2025_1, title = {DR-SCAN : AN INTERPRETABLE DUAL-BRANCHRESIDUAL SPATIAL AND CHANNEL ATTENTIONNETWORK FOR REMOTE SENSING AND GEOSCIENCEIMAGE SUPER-RESOLUTION}, author = {Neelakantan, Suraj and Längkvist, Martin and Loutfi, Amy}, year = {2025}, url = {1958053}, language = {eng}, abstract = {High-resolution imaging is essential in remote sensing and geoscience for precise environmental and geological analysis. DR-SCAN (Dual-Branch Residual Spatial and Channel Attention Networks), a neural network architecture for image super-resolution across these domains, is introduced. Evaluated on the UCMerced Land Use and DeepRock-SR datasets, DR-SCAN demonstrates adaptability to diverse remote sensing landscapes and effectiveness in resolving pore-scale geological features. Feature map visualizations highlight the model’s ability to prioritize crit-ical spatial features, enhancing interpretability for domain-specific applications.}, file = {https://oru.diva-portal.org/smash/get/diva2:1958053/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gomezalvaro_2025_2, title = {DRUG LEVELS AND ANTI-DRUG ANTIBODIES OVER 2 YEARS OF BELIMUMAB THERAPY IN SYSTEMIC LUPUS ERYTHEMATOSUS}, author = {Gomez, Alvaro and Walhelm, Tomas and Loeff, Floris and Jönsen, Andreas and Nikolopoulos, Dionysis and Van den Broek, Bryan and Bengtsson, Anders and De Vries, Annick and Rispens, Theo and Sjöwall, Christopher and Parodis, Ioannis}, year = {2025}, journal = {Journal of Rheumatology}, volume = {52}, number = {Suppl. 1}, pages = {249--249}, doi = {10.3899/jrheum.2025-0390.PV270}, url = {2014528}, language = {eng}, publisher = {The Journal of Rheumatology}, issn = {0315-162X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hedspngmattias_2025, title = {Dry Needle Arthroscopy of the Wrist in an Office Setting : 15 Cases}, author = {Hedspång, Mattias and Sagerfors, Marcus and Kakar, Sanjeev and Ryen, Linda and Asklöf, Peter and Reiser, Daniel}, year = {2025}, journal = {Journal of Hand Surgery-American Volume}, volume = {50}, number = {12}, pages = {1524.e1--1524.e6}, doi = {10.1016/j.jhsa.2025.01.015}, url = {1982414}, language = {eng}, publisher = {Elsevier}, keywords = {diagnostic arthroscopy; ligament injury; minimally invasive; wrist}, abstract = {PURPOSE: Arthroscopy remains the gold standard to diagnose ligamentous lesions in the wrist. The coronavirus disease (COVID)-19 pandemic put a strain on resources, prompting an increase in procedures performed under local anesthesia. Dry needle arthroscopy of the wrist has previously been used in the operating room. The purpose of this study was to assess the results and patient satisfaction of wrist arthroscopy under local anesthesia in an office setting.METHODS: A prospective series of 15 patients presenting with wrist trauma and a suspected ligamentous injury to the wrist were included. All patients underwent radiography and magnetic resonance imaging (MRI) before the procedure. Dry needle arthroscopy was performed by a surgeon with a nurse assistant, in the office under local anesthesia, using a traction device for distraction of the wrist. Patient satisfaction was assessed with the Picker Patient Experience-15 (PPE-15) questionnaire.RESULTS: The patient's mean age was 34 years (range: 18-51). There were no intraoperative complications or postoperative infections. The median PPE-15 score was 90 of 100. Visualization of the intraarticular structures was excellent.CONCLUSIONS: Dry needle arthroscopy of the wrist under local anesthesia in an office setting seems to be a feasible method to diagnose ligament injuries of the wrist. Patient satisfaction with the procedure was high.CLINICAL RELEVANCE: Dry needle arthroscopy of the wrist under local anesthesia in-office could facilitate and expedite diagnosis of wrist injuries.}, issn = {0363-5023} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_eklundpatrik_2025, title = {DSM Relational Structures Extended With Fuzzy Sets Of Higher Types}, author = {Eklund, Patrik and Löfstrand, Magnus and Paul, Satyam and Goodarzi, Mehdi}, year = {2025}, pages = {21--30}, url = {1980583}, language = {eng}, keywords = {many-valued relation; powerset; relational composition; fuzzy set of higher type; mineral mining}, abstract = {In this paper we show how relational representations of design structure matrices (DSM), on the one hand, enables to describe domain dependencies and connections as relational composition, and, on the other hand, invites to using a variety of algebraic structures for the sets of qualifications attached with non-binary matrices. Particularly, we use fuzzy sets of higher types to model qualifications in many-valued DSMs where compositional techniques allow for extending the use of fuzzy sets of higher types also in the setting of multidomain matrices (MDM). We further show how clustered domains can be embedded as modelled within powersets of domains, thus providing a further justification for adopting the relational view of DSMs, particularly as the qualification space needs to support folding and unfolding across hierarchies in clustered domains. Our case study is drawn from scenarios involving maintenance of equipment in mineral mining.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_smitedarja_2025, title = {Dual Effects of Hybrid Working on Performance : More Work Hours or More Work Time}, author = {Smite, Darja and Tkalich, Anastasiia and Moe, Nils Brede and Chatzipetrou, Panagiota and Klotins, Eriks and Helland, Per Kristian}, year = {2025}, volume = {524}, pages = {63--70}, doi = {10.1007/978-3-031-72781-8_7}, url = {1941750}, language = {eng}, publisher = {Springer}, keywords = {hybrid; flexible; remote; performance; work hours}, abstract = {Work in software development companies has become increasingly hybrid with employees altering days of working in the office with days of working remotely from home. Yet, little is know about the efficiency of such way of working because the current scale of remote working is unprecedented. In this paper, we present our findings from a company-wide survey at Storebrand - a large-scale Norwegian fintech company, focusing on perceived performance. Our analysis of 192 responses shows that most employees report being able to perform the planned tasks. Further, half of respondents perceive to have increased work hours. Through qualitative analysis of open-ended commentaries of respondents we learned that remote working has dual effects on the perceived work hours - some employees report working longer hours and others report having more work time due to efficient use of the time throughout the day. Finally, we recommend managers to discuss and address the concerning habits of employees caused by increased connectivity and inability to stop working, before these lead to burnout and disturbances in the work/life balance.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wanglulu_2025, title = {Dual-Server Privacy-Preserving Collaborative Deep Learning : A Round-Efficient, Dynamic and Lossless Approach}, author = {Wang, Lulu and Zhang, Lei and Choo, Kim-Kwang Raymond and Domingo-Ferrer, Josep and Conti, Mauro and Gao, Yuanyuan}, year = {2025}, journal = {IEEE Transactions on Dependable and Secure Computing}, volume = {22}, number = {6}, pages = {7759--7772}, doi = {10.1109/TDSC.2025.3599911}, url = {2028242}, language = {eng}, publisher = {IEEE}, keywords = {cryptography; privacy; accuracy; servers; noise; computational modeling; training; data models; homomorphic encryption; data privacy; deep learning; collaborative deep learning; federated learning}, abstract = {To address limitations in existing privacy-preserving collaborative deep learning (CDL) schemes, we propose a dual-server privacy-preserving CDL scheme based on homomorphic encryption and a masking technique. Specifically, in our scheme a random seed is used to initialize a pseudorandom generator that produces multiple pseudorandom numbers. These pseudorandom numbers, along with a random noise, are utilized to generate masks that are added to all parameters of a participant's locally trained model. By using homomorphic encryption, the random noise can be encrypted and eventually used to remove the masks with low message expansion. This also ensures that the global model is lossless in accuracy. Furthermore, if participants join or leave the system, only the time required to complete both model update aggregation and encrypted masks aggregation is affected. We demonstrate that our scheme is round-efficient, dynamic and lossless. We also show that it is secure against inference attacks and can resist collusion attacks of up to t-2 participants and one of the two servers, where t is a security parameter indicating the minimum number of participants that participate in an aggregation round.}, issn = {1545-5971} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_erikssonmats_2025_4, title = {DURCOM : Riskkommunikation för ett robust digitalurbant samhälle}, author = {Eriksson, Mats}, year = {2025}, url = {2022755}, language = {swe}, publisher = {Örebro universitet}, keywords = {riskkommunikation; kommuner; krisberedskap; kampanjer}, abstract = {Denna slutrapport samlar lärdomar från det mångvetenskapliga forskningsprojektet Riskkommunikation för ett robust digitalurbant samhälle/Digital Urban Risk Communication (DURCOM). Projektet studerade kommuners och medborgares riskkommunikation för krisberedskap och krisberedskapskultur, i ett alltmer digitalt samhälle. Projektet finansierades av Myndigheten för samhällsskydd och beredskap (MSB) och genomfördes åren 2020–2025}, file = {https://oru.diva-portal.org/smash/get/diva2:2022755/FULLTEXT01.pdf} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_saersjohannes_2025, title = {Dust Exposure as a Risk Factor for Respiratory Disease}, author = {Saers, Johannes}, year = {2025}, url = {1964053}, language = {eng}, publisher = {Örebro University}, keywords = {dust; exposure; pm2.5; lung function}, abstract = {This thesis aimed to explore the associations between subjective and objective exposures to airborne small particulate matter and its impact on respiratory symptoms, lung function, and respiratory diseases.The first paper investigated whether Swedish soldiers exposed to desert environments had a higher prevalence of respiratory symptoms. The second paper examined the relationship between airborne particulate matter exposure in Mali and the risk of developing respiratory symptoms, lung function impairment, and airway inflammation, measured as FeNO. The third paper focused on occupational exposure to silica, wood, and paper dust and its associations with respiratory symptoms and lung function. The final paper assessed the effects of traffic and occupational exposure on self-reported respiratory symptoms, asthma, and chronic bronchitis in a multicenter Swedish population. Results indicated that soldiers in desert environments experienced a higher prevalence of wheezing and coughing, with a dose-response relationship showing that longer deployment times correlated with increased symptoms. FEV1 significantly decreased after exposure to desert storms, likely due to small particulate matter. Additionally, exposure to inhalable wood dust was linked to reduced lung function, while traffic and occupational exposures were independently associated with respiratory issues. The findings highlight the need for pollution reduction measures and thorough exposure histories when managing respiratory symptoms amongst patients.}, file = {https://oru.diva-portal.org/smash/get/diva2:1964053/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_aatsinkiannakatariina_2025, title = {Dynamics of gut metabolome and microbiota maturation during early life}, author = {Aatsinki, Anna-Katariina and Lamichhane, Santosh and Isokääntä, Heidi and Sen, Partho and Kråkström, Matilda and Alves, Marina Amaral and Keskitalo, Anniina and Munukka, Eveliina and Karlsson, Hasse and Perasto, Laura and Lukkarinen, Minna and Oresic, Matej and Kailanto, Henna-Maria and Karlsson, Linnea and Lahti, Leo and Dickens, Alex M.}, year = {2025}, journal = {iScience}, volume = {28}, number = {11}, doi = {10.1016/j.isci.2025.113596}, url = {2016354}, language = {eng}, publisher = {Cell Press}, abstract = {Early-life gut microbiome-metabolome crosstalk plays a crucial role in maintaining host physiology. The microbially produced metabolites often convey effects on host health and physiology. This study investigates the gut metabolites, including short-chain fatty acids (SCFAs), bile acids (BAs), and polar metabolites, and their relationship to gut microbiota composition in a birth cohort of 670 children. Samples were collected at 2.5 (n = 272), 6 (n = 232), 14 (n = 289), and 30 months (n = 157) of age. We identified the trajectories of the fecal metabolome that relate to the maturation of the early-life gut micro-biota. We found that prevalent gut microbial abundances were associated with microbial metabolite levels, particularly in 2.5-month-old infants. Here, the abundances of early colonizers, e.g., Bacteroides, Escherichia, and Bifidobacterium, were associated with microbial metabolites, especially secondary BAs, particularly in breastfed infants. Our results suggest that early-life gut microbiota associates with changes in metabolome composition, particularly BAs, which may have physiological implications.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_haarsjonathan_2025, title = {Dynamics of SARS-CoV-2 variants and mutations in Central Sweden between 2023 and 2024 and their potential implications on monoclonal antibodies pemivibart and sipavibart as PrEP in the region}, author = {Haars, Jonathan and Wallin, Frans and Elfving, Karin and Jonsson, Anna-Karin and Ellström, Patrik and Mölling, Paula and Lindh, Johan and Yin, Hong and Sundqvist, Martin and Kaden, René and Palanisamy, Navaneethan and Lennerstrand, Johan}, year = {2025}, journal = {Infectious Diseases}, volume = {57}, number = {10}, pages = {956--965}, doi = {10.1080/23744235.2025.2509011}, url = {1963472}, language = {eng}, publisher = {Taylor & Francis}, keywords = {sars-cov-2; covid-19; nanopore sequencing; monoclonal antibodies; pre-exposure prophylaxis; sipavibart; pemivibart}, abstract = {Background: Monoclonal antibodies (mAbs) are an important option against SARS-CoV-2, especially as pre-exposure prophylaxis (PrEP) for patients with immune system impairment. PrEP mAbs like sipavibart and pemivibart have been approved for limited use in several countries. Certain SARS-CoV-2 variants carry mutations in the spike (S) protein, conferring resistance to these mAbs.Objectives: We aimed to examine the relative abundance of different circulating SARS-CoV-2 variants/mutations in central Sweden between 2023 and 2024, and to predict the effectiveness of sipavibart and pemivibart.Methods: An amplicon-based Nanopore sequencing method was used for sequencing SARS-CoV-2 samples. Coronapp was used to identify mutations in these sequences. Using the published in vitro resistance data for sipavibart and pemivibart, the effectiveness of these mAbs was inferred.Results: We have observed that the relative abundance of the KP.3.1.1 variant and the Q493E mutation started to increase in the later part of 2024 in the region. Also, since April 2024, the relative abundance of the F456L mutation reached 100% during many weeks until the end of the study period. The KP.3.1.1 variant is significantly resistant to pemivibart. Further, the presence of the F456L mutation in the Omicron subvariants confers high fold resistance towards sipavibart.Conclusion: The use of sipavibart or pemivibart as PrEP for COVID-19 in the region may currently not be effective unless new SARS-CoV-2 variants appear not containing these resistance mutations. Further, new mAbs under development as PrEP for COVID-19 can be effectively used by routinely sequencing SARS-CoV-2 in patients to identify variants and resistance mutations.}, issn = {2374-4235} } @book{ca0f099bbf2a435cee8f97bef5e8cbaa_gunnarssonlena_2025_1, title = {Dynamics of Sexual Consent : Sex, Rape and the Grey Area In-Between}, author = {Gunnarsson, Lena}, year = {2025}, doi = {10.4324/9781003535546}, url = {1915029}, language = {eng}, publisher = {Routledge}, keywords = {bdsm; consent; feminist theory; gay men and consent; gender; grey-area; heterosexuality; lgbtq; rape; sex; sexual consent; sexual scripts; sexual violence}, abstract = {How does sexual consent work? How do we know that another person really wants to have sex with us? Why do people sometimes give in to sex that they are not in the mood for? And how come it is sometimes difficult to draw a sharp line between sex and assault? Dynamics of Sexual Consent addresses these questions based on deeply personal interviews with 20 Swedish women and men of various ages and sexual orientations. In doing so, it contributes to understandings of sexual consent and sexual grey areas through its combination of conceptual rigour, analytical detail and empirical richness.While starting in the legal definition of consent as voluntary participation, the book broadens the discussion to a wider sociological and philosophical sphere where gendered power dynamics and relational dependencies challenge simplistic understandings of voluntariness. Contesting tendencies to see miscommunication as the key problem related to consent, it shows that emotional aspects are often the main factor standing in the way of genuinely consensual interactions. While the analysis is informed by a gender perspective emphasizing the gendered power asymmetries of heterosexuality, it also foregrounds men’s vulnerability and the power dynamics of samesex interactions. A key argument of the book is that, given the contextual and ambiguous nature of sexual interactions, it is impossible to delineate unequivocal and concretely applicable guidelines for what counts as consent. To compensate for the lack of universal, fail-safe rules, what is needed is an intensified collective reflection on consent and sexual grey areas, which can make individuals better equipped to identify and respect their own and others’ boundaries.An empirically rich and conceptually sophisticated contribution to understanding of sexual consent and sexual grey areas, Dynamics of Sexual Consent will be of interest to scholars and students of gender studies, sociology and criminology.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_isacssonalexander_2025_1, title = {Dynastic Centralisation and Court Constellations : Duke-King Relations in Early Seventeenth-Century Sweden}, author = {Isacsson, Alexander}, year = {2025}, journal = {The Court Historian}, volume = {30}, number = {1}, pages = {34--56}, doi = {10.1080/14629712.2025.2468077}, url = {1945975}, language = {eng}, publisher = {Maney Publishing}, keywords = {johan of östergötland; duke; royal spare; ducal court; swedish court; dynastic centralisation}, abstract = {This article explores how dynastic centralisation in early seventeenth-century Sweden shaped relations between dukes and kings as well as their respective courts. Focusing on Duke Johan of Östergötland, it examines how courtly socialisation influenced Johan’s loyalty to his uncle, Charles IX, and cousin, Gustavus Adolphus. Drawing on correspondence and court records, the study argues that Johan’s childhood socialisation was instrumental in fostering his allegiance and contributed to a novel court configuration. While ducal courts in sixteenth-century Sweden had often been divisive, the early seventeenth century witnessed the emergence of a more cohesive constellation of courts. The ducal court remained a platform for princely display and patrimonial authority, but the relationship between ducal and royal courts was characterised by a harmonious coexistence and interaction. This transformation was intrinsically linked to dynastic centralisation, which redefined the role of cadet princes, fostering greater compliance within the royal family and hierarchy.}, issn = {1462-9712} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindblomjulius_2025, title = {Dysregulation of innate and adaptive lymphoid immunity may have implications for symptom attribution and predict responses to targeted therapies in neuropsychiatric systemic lupus erythematosus}, author = {Lindblom, Julius and Barturen, Guillermo and Beretta, Lorenzo and Toro-Dominguez, Daniel and Carnero-Montoro, Elena and Borghi, Maria Orietta and Castillo, Jessica and Iacobaeus, Ellen and Enman, Yvonne and Mohan, Chandra and Alarcon-Riquelme, Marta E. and Nikolopoulos, Dionysis and Parodis, Ioannis}, year = {2025}, journal = {Journal of translational autoimmunity}, volume = {11}, doi = {10.1016/j.jtauto.2025.100296}, url = {1985807}, language = {eng}, publisher = {Elsevier}, keywords = {systemic lupus erythematosus; neuropsychiatric systemic lupus erythematosus; precision medicine; druggability; biologics; transcriptome; gene expression}, abstract = {Objectives: To gain insights into the pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE) and identify potential drug targets through investigation of whole-blood human transcriptome.Methods: We analysed differentially expressed genes in peripheral blood from active central nervous system (CNS) lupus (n = 26) and active non-neuropsychiatric SLE (n = 38) patients versus healthy controls (n = 497) from the European PRECISESADS project (NTC02890121). We further explored dysregulated gene modules in active CNS lupus and their correlation with serological markers. Lastly, we performed regulatory network and druggability analysis.Results: Unsupervised weighted gene co-expression network analysis (WGCNA) revealed 23 dysregulated gene modules and two subgroups of active CNS lupus. The interferon gene module was prominently upregulated in subgroup 1, while the B cell, T cell, and cytotoxic/natural killer (NK) cell modules were downregulated. Subgroup 2 showed less marked dysregulation patterns. Subgroup 1 had lower estimated proportions of lymphoid cell subsets and proportionally more patients positive for anti-dsDNA antibodies compared to subgroup 2, pointing to molecularly distinct subgroups or misclassification of subgroup 2. In silico prediction algorithms demonstrated a greater anticipated response to anifrolumab, C3 inhibitors, and calcineurin inhibitors for patients in CNS lupus subgroup 1 compared with subgroup 2.Conclusions: Gene dysregulation patterns related to innate and adaptive lymphoid immunity separated active CNS lupus patients into two distinct subgroups with differential anticipated response to type I interferon, C3, and calcineurin inhibition. Our study provides a conceptual framework for precision medicine in NPSLE and implications for overcoming the major clinical challenge of attributing neuropsychiatric features to SLE versus other causes.}, issn = {2589-9090} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_boodfrida_2025, title = {Early Childhood Aggression and Peer Victimization - Examining Latent Profiles and Associations with Adolescent Delinquency}, author = {Bood, Frida and Hellfeldt, Karin and Evans, Brittany and Andershed, Henrik}, year = {2025}, journal = {Journal of Aggression, Maltreatment & Trauma}, volume = {34}, number = {11}, pages = {1672--1693}, doi = {10.1080/10926771.2025.2585274}, url = {2014444}, language = {eng}, publisher = {Routledge}, keywords = {aggression; delinquency; early childhood; latent profile analysis; longitudinal; peer victimization}, abstract = {Childhood aggression and peer victimization are associated not only with each other but also with future delinquency. However, existing literature focuses almost entirely on aggression and peer victimization in middle childhood or adolescence, making it unclear whether such associations can be found in early childhood. The current study aimed to identify latent profiles of children based on early childhood aggression and peer victimization, and to examine whether profiles were associated with delinquent outcomes (theft, violence, and vandalism) in adolescence. We used longitudinal data from 2,113 participants (53.4% boys) between the ages of 3 and 5 years at baseline (M = 3.86, SD = 0.85). We applied a three-step latent profile analysis on teacher and parent measures of aggression and peer victimization and used self-reports about delinquent behaviors from ages 14 to 16 years as outcome measures. We accounted for potential clustering effects of preschool classes and adjusted analyses for age, sex, and socio-economic status. We identified four profiles of children: non-involved (68.7%), victims (16.3%), aggressors (13.7%), and aggressive victims (1.3%), but found no significant associations between latent profiles and delinquency. As nearly one-third of participants were identified as early childhood victims, aggressors, or aggressive victims, we highlighted the importance of addressing early childhood aggression and peer victimization since the risk for negative development (i.e. later criminality or social adjustment issues) has been shown in prior research.}, issn = {1092-6771} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_quennerstedtann_2025, title = {Early childhood education teachers’ conceptions of children’s rights and the role of early education for children’s rights}, author = {Quennerstedt, Ann}, year = {2025}, journal = {Cogent Education}, volume = {12}, number = {1}, doi = {10.1080/2331186X.2025.2539215}, url = {1972357}, language = {eng}, publisher = {Taylor & Francis}, keywords = {uncrc; children's rights; human rights; ecec; early childhood education; teachers' perceptions; teachers' understanding; education; early years; environment; urban studies}, abstract = {The article examines Swedish early childhood education teachers’ conceptions of children’s rights and their understanding of the role and assignment of early childhood education in relation to rights. The study also investigates how understandings have changed over time as teachers were interviewed in two different rounds ten years apart. Four conceptions of what children’s rights entail in early childhood education were identified: children should be respected, children are entitled to feel safe, learning is a right, and rights for children need to be adapted. Each of these centres a specific right or rights aspect, in turn pointing out a particular task for early childhood education. The four rights conceptions appear at both interview times; however, a higher proportion of the teachers express them in the second round of interviews, and the reasoning around the notions is more elaborated at this point. The findings consequently indicate a high stability over time in early childhood teachers’ basic understanding of children’s rights and what the role of education is. At the same time, teachers’ awareness and knowledge of children’s rights have evidently increased over time.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_nilssonolof_2025, title = {Early oral cancer : evaluation of ultrasound, narrow band imaging and marginal mandibulectomy}, author = {Nilsson, Olof}, year = {2025}, url = {1925088}, language = {eng}, publisher = {Örebro University}, keywords = {ultrasound; depth of invasion; tumour borders; surgical margins; narrow band imaging; marginal mandibulectomy; bone invasion}, abstract = {The incidence of oral squamous cell carcinoma (OSCC) in Sweden increased by 30 % between 2008 and 2021. Surgical resection with clear margins is the first line of treatment. The aim of the present thesis was to evaluate preoperative assessments and intraoperative techniques to improve the surgical margins, while preserving healthy tissue to optimise the functional outcome.Study I prospectively included 40 patients with oral tongue cancer (SCCOT). Depth of invasion (DOI) measured with ultrasound (US) was compared to magnetic resonance imaging (MRI). Histopathological DOI was the gold standard. DOI by US was the most accurate method. MRI overestimated DOI and could not assess a substantial proportion of the tumours. Study II compared US-assisted resection in 34 patients with SCCOT, to resections performed without US in 76 historical controls. Insufficient deep resection margins (<5.0mm) were seen in 8 of 34 patients (23.5%) in the study group, compared to 31 of 76 (40.8%) in the conventional group (unadjusted RR 0.58, 95% CI 0.30-1.12, unadjusted mean difference 1.4mm, 95% CI 0.1-2.7, adjusted mean difference not significant). US-assisted resection has the potential to improve the deep resection margins, though larger studies with more robust data are needed. Study III examined visualisation of mucosal tumour borders with narrow band imaging (NBI) compared to white light (WL) in 34 patients with OSCC. NBI was not found to better delineate the true tumour borders compared to WL. Study IV retrospectively investigated preoperative predictors for local recurrence (LR) in gingival cancers of the mandible; treated with marginal mandibulectomy in 67 patients. Cox regression analyses found edentulous patients, more advanced pT-stage and positive soft tissue margins to increase the risk for LR.}, file = {https://oru.diva-portal.org/smash/get/diva2:1925088/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_raatikainenpekka_2025, title = {Early substrate-based catheter ablation vs. antiarrhythmic drug therapy for ventricular tachyarrhythmias among patients with prior myocardial infarction : the MANTRA-VT randomized trial}, author = {Raatikainen, Pekka and Mäkynen, Heikki and Hartikainen, Juha and Urstad, Mats Jensen and Konkola, Leena and Sandgaard, Niels C. F. and Lukac, Peter and Johannessen, Arne and Jönsson, Anders and Schuster, Peter and Blomström-Lundqvist, Carina and Kuutti, Jussi and Lavikainen, Piia and Parikka, Hannu}, year = {2025}, journal = {Europace}, volume = {27}, number = {10}, doi = {10.1093/europace/euaf236}, url = {2006734}, language = {eng}, publisher = {Oxford University Press}, keywords = {antiarrhythmic drug therapy; icd therapy; myocardial infarction; radiofrequency catheter ablation; randomized trial; ventricular tachyarrhythmia}, abstract = {AIMS: Ventricular tachyarrhythmias (VT/VF) are common among patients with prior myocardial infarction (MI). MANTRA-VT trial was designed to compare the efficacy and safety of early substrate-based radiofrequency catheter ablation (RFCA) to antiarrhythmic drug (AAD) therapy for ventricular tachyarrhythmias.METHODS AND RESULTS: We randomly assigned 58 AAD naïve post MI patients with implantable cardioverter defibrillator (ICD) and at least one documented VT/VF episode after the device implantation to an initial treatment strategy of substrate-based RFCA or AAD therapy. The primary endpoint was cumulative number of ventricular tachyarrhythmias (VT/VF burden) at 12 months. The secondary endpoints included all-cause mortality, hospitalization, adverse events, and VT/VF burden at 24 months. Analyses were performed on an intention-to-treat basis. The median number of VT/VF episodes at 12 months was zero in both the RFCA (range 0-3) and the AAD group (range 0-23) (P = 0.454), whereas the rate of appropriate ICD shocks was 7% and 30% in the RFCA and the AAD groups (P = 0.026), respectively. During the extended follow-up, 82% of the patients in the RFCA group and 63% in the AAD group had no ICD therapies (P = 0.012). There was no significant difference between the groups in total mortality (HR 1.02, 95% CI 0.20-5.11, P = 0.86) and hospitalization (HR 1.35, 95% CI 0.36-5.09. P = 0.66) at 24 months. Therapy-related adverse events occurred in 3.6% and 16.7% of the patients in the RFCA and the AAD groups (P = 0.10), respectively.CONCLUSION: Early substrate-based RFCA was associated with reduced risk of ICD therapies, but with no meaningful difference in VT/VF burden, mortality, hospitalization, and adverse events.}, issn = {1099-5129} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_ervolaura_2025_1, title = {East-Nordic Procedural Law – The Same Origins in the Code of Judicial Procedure from 1734}, author = {Ervo, Laura}, year = {2025}, pages = {66--75}, url = {2004372}, language = {eng}, publisher = {Iustus förlag} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ssegonjarichard_2025, title = {Economic evaluation of long-term oxygen therapy prescribed for 24 hours versus 15 hours a day in patients with severe hypoxemic respiratory failure}, author = {Ssegonja, Richard and Sundh, Josefin and Andersson, Anders and Björklund, Filip and Blomberg, Anders and Currow, David and Janson, Christer and Lindberg, Eva and Palm, Andreas and Ekström, Magnus}, year = {2025}, journal = {European Respiratory Journal}, volume = {66}, number = {Suppl. 69}, doi = {10.1183/13993003.congress-2025.OA6540}, url = {2037274}, language = {eng}, publisher = {European Respiratory Society}, abstract = {Background: Long-term oxygen therapy (LTOT) given for at least 15 hours/day improves survival in patients with severe chronic hypoxemia. The recent REDOX trial (registry-based randomized controlled trial of treatment duration and mortality in long-term oxygen therapy), showed that LTOT prescribed for 24 hours/day was not superior to 15 hours/day in terms of hospitalization or death or self-reported outcomes. This study examines the cost-effectiveness of prescribing LTOT 24 h/day compared to 15 h/day.Methods: A cost minimization analysis was conducted on the cost data from the REDOX trial of 241 patients with severe hypoxemic respiratory failure randomized (1:1 ratio) to either LTOT 24 h/day (n=117) or 15 h/day (n=124) and followed-up for 12 months. Data on care consumption were retrieved from national registries and included prescribed medication costs, specialised outpatients- and inpatient care usage. Mean differences in healthcare consumption costs between groups were analyzed using generalized linear models. The cost analysis took a healthcare payer perspective, values in USD 2024 prices.Results: At 12 months follow-up, the LTOT 24 h/day group compared to LTOT 15 h/day, had significantly decreased mean respiratory specific medication costs, -175 USD 95% CI (-329 to -29) and increased LTOT costs 164 USD 95% CI (74 to 256), even after covariate adjustment. There were no significant differences in mean specialised outpatient-, and inpatient care costs, total medication costs or overall total costs, -4 951 USD 95% CI (-10 666 to 444).Conclusion: LTOT prescribed 24 h/day compared to 15h/day did not reduce overall care consumption costs.}, issn = {0903-1936} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_staartjesvictore_2025, title = {Editorial : Cerebrospinal fluid flow imaging in Chiari Malformation type 1}, author = {Staartjes, Victor E. and Öhlén, Erik and Lilja, Anders and Edström, Erik and Elmi-Terander, Adrian}, year = {2025}, journal = {Acta Neurochirurgica}, volume = {167}, number = {1}, doi = {10.1007/s00701-025-06713-2}, url = {2016633}, language = {eng}, publisher = {Springer}, keywords = {cerebrospinal fluid; chiari; flow; imaging; indication; surgical decision making}, issn = {0001-6268} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_guptashashank_2025, title = {Editorial : Host-microbiota immuno-interactions for personalized microbial therapeutics}, author = {Gupta, Shashank and Raghav, Sunil Kumar and Chauhan, Nar Singh}, year = {2025}, journal = {Frontiers in Immunology}, volume = {16}, doi = {10.3389/fimmu.2025.1716098}, url = {2013767}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {host-microbe interactions; human microbiota; microbiome therapeutics; microbiota dysbiosis; personalized therapy} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_barkerruchtinatalie_2025, title = {Education for Sustainable Development : Fostering Sustain‘abilities’ in Sports Coaches}, author = {Barker-Ruchti, Natalie and Purdy, Laura G.}, year = {2025}, doi = {10.4324/9781003439646-9}, url = {1953082}, language = {eng}, publisher = {Routledge}, abstract = {Consensus is that despite critical discussions, formal coach education is limited in equipping practitioners to operate within complex and ever-changing sport environments. In this article, we (1) introduce Education for Sustainable Development (ESD) and consider its value in relation to coach education; (2) conceptualise how coach education can foster sustain‘abilities’ and (3) showcase the university course (read also module; paper) IIG206 Sustainable Sports Coaching, which was developed based on the ESD approach and delivered to third-year undergraduate sports coaching students at the University of Gothenburg, Sweden. Important considerations include pedagogical approach and delivery, time to reimagine a course, positioning of course in a degree programme, course time frame, curricular coherence and teacher flexibility.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_quennerstedtann_2025_1, title = {Educational Issues in Children’s Rights Studies – A Systematic Research Synthesis}, author = {Quennerstedt, Ann and Moody, Zoé and Gillett-Swan, Jenna}, year = {2025}, url = {1999270}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rodanakimaria_2025_1, title = {Effect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty : a randomized-controlled pilot study}, author = {Rodanaki, Maria and Rask, Eva and Lodefalk, Maria}, year = {2025}, journal = {Journal of Pediatric Endocrinology & Metabolism (JPEM)}, volume = {38}, number = {3}, pages = {288--291}, doi = {10.1515/jpem-2024-0606}, url = {1931379}, language = {eng}, publisher = {Freund Publishing House, Ltd.}, keywords = {gonadotropin-releasing hormone; hypothalamic-pituitary-gonadal axis; kisspeptin; precocious puberty}, abstract = {OBJECTIVES: Kisspeptin plays a major role in the onset of puberty by stimulating the gonadotropin-releasing hormone (GnRH) neurons. The aim of this study was to investigate whether GnRH inhibits kisspeptin secretion via a negative feedback mechanism and potential associations between kisspeptin levels and other hormones of importance for pubertal onset.METHODS: Thirteen girls with suspected central precocious puberty underwent a GnRH stimulation test twice in a randomized, placebo-controlled manner. Blood was sampled up to 150 min after an IV injection of either Relefact LHRH® or saline. The levels of kisspeptin, acylated ghrelin, ultrasensitive oestradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), insulin and glucose were analysed.RESULTS: Baseline kisspeptin levels ranged from 9.9 to 201.6 pg/mL. Neither area under the curve for kisspeptin levels nor peaks were significantly lower after the GnRH injection compared to placebo. Baseline kisspeptin and glucose levels tended to be associated (rho=0.55, p=0.051) but no other associations were found between kisspeptin and other hormones.CONCLUSIONS: Basal levels of kisspeptin vary widely in young girls. We found no evidence of a negative feedback mechanism of GnRH on kisspeptin in this small pilot study. The suggested association between kisspeptin and glucose levels needs further investigations.}, issn = {0334-018X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fountoukidisgeorgios_2025, title = {Effect of alcohol consumption on oncological treatment effectiveness and toxicity in patients with cancer : a systematic review and meta-analysis}, author = {Fountoukidis, Georgios and Schiza, Aglaia and Smith, Daniel and Othman, Mukhrizah and Bergman, Marie and Ahlgren, Johan and Lambe, Mats and Irenaeus, Sandra and Valachis, Antonis}, year = {2025}, journal = {BMC Cancer}, volume = {25}, number = {1}, doi = {10.1186/s12885-025-13694-z}, url = {1937971}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {alcohol consumption; cancer treatment; effectiveness; meta-analysis; toxicity}, abstract = {BACKGROUND: Alcohol consumption has been associated with an increased risk of cancer-related mortality. It may also negatively impact oncological therapies, potentially leading to impaired effectiveness or an increased risk of treatment-related toxicities. The aim of this systematic review and meta-analysis was to examine the current evidence regarding the potential effects of alcohol consumption during cancer treatments on both treatment effectiveness and toxicity, irrespective of cancer type.METHODS: A comprehensive literature search was performed across three electronic databases (Medline, Web of Science, Cochrane) covering studies from January 1990 to December 2023. Furthermore, a manual search based on the reference lists of the eligible studies was performed to identify additional potentially eligible studies. Studies were eligible if they involved cancer patients and provided data on alcohol consumption during specific oncological treatments, including its effect on treatment outcomes, or compared treatment effectiveness or toxicity between drinkers and non-drinkers. Studies were excluded if they did not meet these criteria, were duplicates, case reports, conference abstracts, or focused only on cancer-specific or overall survival. Only studies using multivariable analyses to examine the association between alcohol consumption and treatment effectiveness or toxicity were included in the pooled analyses. Pooled Hazard Ratios (HRs) or Odds Ratios (ORs) and their corresponding 95% Confidence Intervals (CIs) were calculated using random-effects models. Study quality was assessed by using the Newcastle-Ottawa scale whereas the GRADE approach was applied to rate the certainty of evidence for pooled analyses.RESULTS: Out of 6734 studies identified through searching, 38 met the inclusion criteria for pooled analyses. Alcohol consumption during radiotherapy, with or without concomitant chemotherapy, was associated with worse disease-free survival (pooled HR: 2.05; 95% CI: 1.09 - 3.89), although the numerically increased risk for locoregional recurrence did not reach statistically significance (pooled HR: 2.01; 95% CI: 0.76 - 5.36). The potential impact of alcohol consumption on chemotherapy-induced neurotoxicity and acute / delayed nausea was not statistically significant. However, alcohol consumption was associated with a lower risk of overall chemotherapy-induced nausea (OR: 0.69; 95% CI: 0.57, 0.84).CONCLUSION: Our findings suggest that alcohol consumption may have a negative impact on radiotherapy, whereas its potential impact on the effectiveness of systemic oncological therapies (chemotherapy, molecular targeted therapy, immunotherapy, endocrine therapy) has not been adequately studied. Similarly, the current evidence on the potential association between alcohol consumption and treatment-related toxicities is weak, highlighting the need for well-designed prospective studies on this topic.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_trauschbriantomas_2025, title = {EFFECT OF HIBERNATION IN BROWN BEARS ON MEASURES OF OXIDIZED LIPOPROTEINS : IMPLICATIONS FOR HUMAN DIETARY TRENDS AND CARDIOVASCULAR DISEASE}, author = {Trausch, Brian Tomas and Isaksson, Helena Sofia and Evans, Alina L. and Kindberg, Jonas and Yang, Xiaohong and Fröbert, Ole and Tsimikas, Sotirios}, year = {2025}, journal = {Journal of the American College of Cardiology}, volume = {85}, number = {12}, pages = {2422--2422}, url = {1953445}, language = {eng}, publisher = {Elsevier}, issn = {0735-1097} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_simmonsdavid_2025, title = {Effect of treatment for early gestational diabetes mellitus on neonatal respiratory distress : A secondary analysis of the TOBOGM study}, author = {Simmons, David and Immanuel, Jincy and Hague, William M. and Coat, Suzette and Teede, Helena and Nolan, Christopher J. and Peek, Michael J. and Flack, Jeff R. and McLean, Mark and Wong, Vincent W. and Hibbert, Emily J. and Kautzky-Willer, Alexandra and Harreiter, Jürgen and Backman, Helena and Gianatti, Emily and Sweeting, Arianne and Mohan, Viswanathan and Cheung, N. Wah and TOBOGM Research Group,}, year = {2025}, journal = {British Journal of Obstetrics and Gynecology}, volume = {132}, number = {8}, pages = {1087--1095}, doi = {10.1111/1471-0528.17938}, url = {1891088}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {diagnostic criteria; early gestational diabetes mellitus; first trimester; gestational diabetes mellitus; neonatal intensive care; neonatal respiratory distress; pregnancy; screening}, abstract = {OBJECTIVE: To identify factors associated with neonatal respiratory distress (NRD) in early Gestational diabetes mellitus (eGDM).DESIGN: Nested case-control analysis of the TOBOGM trial.SETTING: Seventeen hospitals: Australia, Sweden, Austria and India. POPULATION: Pregnant women, <20 weeks' gestation, singleton, GDM risk factors.METHODS: Women with GDM risk factors completed an oral glucose tolerance test (OGTT) before 20 weeks: those with eGDM (WHO-2013 criteria) were randomised to immediate or deferred GDM treatment. Logistic regression compared pregnancies with/without NRD, and in pregnancies with NRD, those with/without high-dependency nursery admission for ≤24 h with those admitted for >24 h. Comparisons were adjusted for age, pre-pregnancy body mass index, ethnicity, smoking, primigravity, education and site. Adjusted odds ratios (95% CI) are reported.MAIN OUTCOME MEASURES: NRD definition: ≥4 h of respiratory support (supplemental oxygen or supported ventilation) postpartum. Respiratory distress syndrome (RDS): Supported ventilation and ≥24 h nursery stay.RESULTS: Ninety-nine (12.5%) of 793 infants had NRD; incidence halved (0.50, 0.31-0.79) if GDM treatment was started early. NRD was associated with Caesarean section (2.31, 1.42-3.76), large for gestational age (LGA) (1.83, 1.09-3.08) and shorter gestation (0.95, 0.93-0.97 per day longer). Among NRD infants, >24 h nursery-stay was associated with higher OGTT 1-h glucose (1.38, 1.08-1.76 per mmol/L). Fifteen (2.0%) infants had RDS.CONCLUSIONS: Identifying and treating eGDM reduces NRD risk. NRD is more likely with Caesarean section, LGA and shorter gestation. Further studies are needed to understand the mechanisms behind this eGDM complication and any long-term effects.}, issn = {1470-0328} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kollatoschristos_2025, title = {Effectiveness of incisional negative pressure wound therapy vs. standard dressings in breast surgery : a systematic review and meta-analysis}, author = {Kollatos, Christos and Sackey, Helena and Öhrn, Catarina and Valachis, Antonis and Eriksson, Staffan and Karakatsanis, Andreas}, year = {2025}, journal = {British Journal of Surgery}, volume = {112}, number = {Suppl. 11}, pages = {xi6--xi6}, doi = {10.1093/bjs/znaf149.021}, url = {1991985}, language = {eng}, publisher = {Oxford University Press}, abstract = {Introduction: Wound-related complications following breast surgery are common and may delay adjuvant treatment, prolong healing time ,and increase morbidity. Incisional negative pressure wound therapy (iNPWT) has been proposed as a strategy to reduce postoperative complications across various surgical procedures. However, its effectiveness in breast surgery remains uncertain.Method: A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines. Studies comparing iNPWT with standard dressings in closed breast surgery incisions were included if they reported at least one wound-related outcome. Comprehensive searches were conducted in MEDLINE, EMBASE, and CENTRAL up to March 2025. A random-effects model using the Hartung-Knapp-Sidik-Jonkman method was applied. Heterogeneity, publication bias, and study quality were assessed using the RoB2 and ROBINS-I tools. The certainty of evidence was evaluated according to the GRADE approach.Result: Twenty-nine studies involving 4,904 patients were included. iNPWT had a modest but significant effect in reducing the risk o fwound dehiscence (RR: 1.07; 95% CI: 1.03–1.12; p < 0.001; I² = 81.6%) and surgical site infection (RR: 1.05; 95% CI: 1.01–1.09; p = 0.02; I² = 84.13%), despite the substantial heterogeneity. Prediction intervals highlighted the substantial between-study variability. Findings for seroma, skin necrosis, heamatoma, and nipple-areolar complex necrosis were inconclusive. Meta-regression identified low BMI and younger age as potential protective factors for skin necrosis, although no predictors were found for other complications.Discussion: iNPWT may reduce specific wound complications in breast surgery, but heterogeneity and methodological limitations constrain conclusions. Further high-quality randomized trials with standardized outcomes are needed.}, issn = {0007-1323} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stabyolsnjohan_2025_2, title = {Effectiveness, toxicity and impact on quality of life of high-dose-rate brachytherapy delivered in two fractions as monotherapy in patients with prostate cancer}, author = {Staby Olsén, Johan and Valachis, Antonis and Johansson, Bengt}, year = {2025}, journal = {Clinical and Translational Radiation Oncology}, volume = {51}, doi = {10.1016/j.ctro.2025.100923}, url = {1935116}, language = {eng}, publisher = {Elsevier}, keywords = {effectiveness; high-dose-rate brachytherapy; monotherapy; prostate cancer; toxicity}, abstract = {PURPOSE: The aim of this retrospective, single-center cohort study was to evaluate the effectiveness and safety of two-fraction high-dose-rate brachytherapy (HDR-BT) as monotherapy in a consecutive cohort of prostate cancer patients.METHODS: We included consecutive patients who received 28 Gy HDR-BT in two fractions (14 Gy × 2) as monotherapy during 2005 to 2021 at our institution. Eligible patients were derived from an institutional database consisting of prospectively collected data. Primary endpoint was biochemical recurrence (BCR) and secondary endpoints included toxicity (assessed through both healthcare provider and patient-reported outcomes) and quality-of-life (QoL) assessment.RESULTS: In total, 175 patients with prostate cancer (94 % classified as low- or intermediate-risk) were treated with HDR-BT during the study period with a median age of 68 years (range: 51-80), and a median follow-up of 60 months (range: 0-174). The estimated five-year cumulative BCR rate was 3.0 % (95 % Confidence Interval (CI): 0 %-13.3 %) for low-risk patients and 9.6 % (95 % CI: 4.7 %-16.7 %) for intermediate-risk patients. PSA exceeding 10 ng/mL at diagnosis was a significant risk factor for BCR (Odds Ratio (OR) = 3.29, 95 % CI: 1.01-10.67) whereas PSA of ≤0.1 ng/ml as nadir was a significant positive prognostic factor, associated with lower risk of BCR (OR = 0.11, 95 % CI: 0.03-0.33). At 12 months, 22 % of the patients had grade 2 and 3 % grade 3 urinary toxicity whereas 2 % of patients had grade 2 and none grade 3 bowel toxicity. At 12 months, 49 % of the patients with at least some erectile function before the treatment, had an impaired function.CONCLUSION: We found that two-fraction HDR-BT as monotherapy among patients with mainly low- and intermediate-risk prostate cancer appears to be safe in terms of biochemical recurrence, with a low proportion of severe urinary and bowel toxicity.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nisanpetra_2025, title = {Effects of Agile Methodologies on Long-Term Success of Startups}, author = {Nisan, Petra and Olurotimi-Odu, Damilola Adebola and Hanif, Muhammad}, year = {2025}, journal = {Technoarete Transactions on Entrepreneurship and International Business}, volume = {3}, number = {1}, pages = {1--4}, url = {1978894}, language = {eng}, publisher = {Technoarete Research And Development Association}, keywords = {agile methodology; agile leadership; startup; entrepreneurship}, abstract = {In this paper, we examine how the early adoption of agile methodologies influences survival of startup companies, and the level of success startup and entrepreneurs can record while embracing specific principles and practices of agile. The research questions aim to explore key areas affecting the success of startups and entrepreneurial ventures. They seek to identify the primary challenges that startups face in achieving long-term success, understand how agile methodologies can be effectively adapted to support their growth and sustainability, and examine the roles of organizational culture and leadership in fostering long-term success through agile practices. Furthermore, in this paper, we will analyze the significance of effective delegation, impact of human factors as it relates to agile projects and findings on risk management among startups. We also list specific agile processes that played a key role in enhancing survival possibilities and chances of startup companies for companies that start-off practicing agile methods. This research is carried out using a mixed-method approach. This study concludes that the early adoption of agile methods significantly enhances the long-term success of startups by improving organizational culture, risk management, and adaptability.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_olaussonalexander_2025, title = {Effects of an opioid-free care pathway vs. opioid-based standard care on postoperative pain and postoperative quality of recovery after laparoscopic bariatric surgery : A multicentre randomised controlled trial}, author = {Olausson, Alexander and Jildenstål, Pether and Andréll, Paulin and Angelini, Eva and Stenberg, Erik and Wallenius, Ville and Öhrström, Henrik and Thörn, Sven-Egron and Wolf, Axel}, year = {2025}, journal = {European Journal of Anaesthesiology}, volume = {42}, number = {8}, pages = {714--726}, doi = {10.1097/EJA.0000000000002193}, url = {1958689}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, abstract = {BACKGROUND: Opioid-free anaesthesia (OFA) may enhance postoperative recovery after bariatric surgery, but its combined effect with opioid-free interventions has not been studied.OBJECTIVES: To compare postoperative pain and recovery after laparoscopic bariatric surgery with a total opioid-free care pathway and conventional opioid-based treatment. DESIGN: A multicentre nonblinded controlled trial. SETTING: Two university hospitals in Sweden.PATIENTS: Adult patients scheduled for laparoscopic bariatric surgery were enrolled between May 2019 and November 2023. Of 837 patients screened, 112 were randomised, and 110 were included in the analysis: 55 in the intervention and 55 in the control group.INTERVENTIONS: Patients were randomised to an opioid-based standard care (control group) or to an opioid-free care pathway (intervention group), including intraoperative OFA and postoperative first-line transcutaneous electrical nerve stimulation (TENS) treatment.MAIN OUTCOME MEASURES: The primary outcome was the change in patient-reported postoperative pain intensity on a numerical rating scale (NRS) from arrival in the postanaesthesia care unit (PACU) until discharge to the surgical ward. Key secondary outcomes were postoperative pain intensity, in-hospital opioid consumption, and postoperative quality of recovery scale (PQRS) scores.RESULTS: There was no difference between the groups regarding the changes in pain intensity from arrival in PACU until discharge to the ward, with mean ± SD changes in NRS of 3.20 ± 3.01 (intervention) vs. 3.15 ± 2.25 (control); mean difference (MD) 0.04 [(95% confidence interval (CI), -1.00 to 1.08); P = 0.97], and pain intensity at 24 h (P = 0.078), 72 h (P = 0.060), and 3 months (P = 0.30) postoperatively. The intervention group had a significantly lower opioid consumption in the PACU; mean morphine equivalents 6.08 ± 12.31 vs. 51.1 ± 14.9 mg; MD -45.0 (95% CI, -50.1 to -39.8) mg; P < 0.0001; and during the hospital stay MD -40.3 (95% CI, -54.4 to -25.9) mg; P < 0.0001. Total PQRS scores did not differ significantly over the 3-month follow-up.CONCLUSION: The opioid-free care pathway offers patients pain relief and recovery outcomes comparable to conventional opioid-based care and reduces opioid use after laparoscopic bariatric surgery.TRIAL REGISTRATION: ClinicalTrials.gov NCT03756961.}, issn = {0265-0215} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bechernina_2025, title = {Effects of anticoagulation in patients with device-detected atrial fibrillation and multiple stroke risk factors : a win ratio analysis of the NOAH-AFNET 6 trial}, author = {Becher, Nina and Köllner, Gina and Bertaglia, Emanuele and Blomström-Lundqvist, Carina and Brandes, Axel and Beuger, Vincent and Calvert, Melanie and Camm, A. John and Cabanelas, Nuno and Chlouverakis, Gregory and Dan, Gheorghe-Andrei and Dichtl, Wolfgang and Diener, Hans Christoph and Fierenz, Alexander and Goette, Andreas and de Groot, Joris R. and Kennes, Lieven Nils and Lip, Gregory Y. H. and Lubinski, Andrzej and Marijon, Eloi and Merkely, Béla and Mont, Lluís and Rajappan, Kim and Rohrer, Ursula and Sarkozy, Andrea and Schotten, Ulrich and Sehner, Susanne and Simantirakis, Emmanuel and Toennis, Tobias and Vardas, Panos and Velchev, Vasil and Wichterle, Dan and Zapf, Antonia and Kirchhof, Paulus}, year = {2025}, journal = {European Heart Journal - Quality of Care and Clinical Outcomes}, volume = {11}, number = {8}, pages = {1351--1358}, doi = {10.1093/ehjqcco/qcaf087}, url = {1994656}, language = {eng}, publisher = {Oxford University Press}, keywords = {device-detected atrial fibrillation; major bleeding; noah-afnet 6; oral anticoagulation; stroke risk; win ratio}, abstract = {AIMS: Patients with device-detected atrial fibrillation (DDAF) have a lower stroke risk than those with ECG-diagnosed AF, requiring careful evaluation of oral anticoagulation benefits vs. its inherent bleeding risk.METHODS AND RESULTS: An unmatched win ratio analysis was performed of the NOAH-AFNET 6 trial dataset, using components of the primary efficacy and safety outcomes of the trial. The primary analysis used this hierarchical order: (1) all-cause death, (2) stroke, (3) systemic or pulmonary embolism/myocardial infarction, and (4) major bleeding. Two additional analyses replaced all-cause death with cardiovascular death or included patient-reported outcomes. Win odds were calculated to account for undecided comparisons. Among 2534 patients 77 ± 7 years old, 947 (37%) women, median CHA2DS2-VA score 3 [interquartile range (IQR), 3-4], median follow-up 21 months (IQR, 10-38) 1 605 280 win ratio pairs were analyzed. The win ratio comparing edoxaban to no anticoagulation was 0.87 (95% CI: 0.68-1.10; P = 0.23). Most comparisons resulted in no clear winner (undecided pairs 84.9%). In the remaining comparisons, edoxaban won in 46% of the cases, placebo in 54%. Death and major bleeding were the most common events. The win odds was 0.98 (95% CI: 0.94-1.01; P = 0.23).CONCLUSIONS: This hypothesis-generating win ratio analysis, integrating death, thrombotic events, and major bleeds with and without quality of life, did not find an advantage of anticoagulation with edoxaban over no anticoagulation in patients with DDAF. The most common events were death and major bleeding.}, issn = {2058-5225} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_singhramanjit_2025, title = {EFFECTS OF AUTOMATED INSULIN DELIVERY SYSTEMS ON GLUCOSE CONTROL IN SUBGROUPS OF INDIVIDUALS WITH TYPE 1 DIABETES IN CLINICAL PRACTICE OVER 1.7 YEARS IN SWEDEN}, author = {Singh, Ramanjit and Imberg, Henrik and Ahmadi, Shilan Seyed and Hallström, Sara and Jendle, Johan and Folino, Anna and Ekström, Marie and Lind, Marcus}, year = {2025}, journal = {Diabetes Technology & Therapeutics}, volume = {27}, number = {Suppl. 2}, pages = {E186--E187}, url = {2038356}, language = {eng}, publisher = {Mary Ann Liebert}, abstract = {Background and Aims: Several studies have shown improvements in glucose control after start of automated insulin delivery (AID). The aim was to understand the effects of AID in subgroups of adults with T1D in clinical practice.Methods: 142 randomly selected adults with T1D using Tandem Control IQ or MiniMed 780G at 6 outpatient diabetes clinics in Sweden were followed over a median of 1.7 years. Correlation analyses were performed to understand what treatment effects can be expected for various patient groups when receiving AID.Results: Mean age was 40 years, 58 (40.8%) were females and 65% used TCIQ. HbA1c (p<.001), TIR (p<.001) and TBR (p=.023) improved rapidly after AID initiation and were sustained for 1.7 years. Effects varied significantly in relation to glucose control. HbA1c decreased by 3 mmol/mol in those with HbA1c 50 mmol/mol, 9 mmol/mol in those with HbA1c 60 mmol/mol, and 14 mmol/mol in those with HbA1c 70 mmol/mol (p<.001). In participants with TIR 50%, 60% and 70% at start of AID, TIR increased by 18%, 13%, and 7%, respectively (p<.001). Patients with large reductions in HbA1c had less effects on TBR and vice versa (r=−0.29, p=.003). Skin reactions were the most common side effects and tended to be more common in women (41% vs 26%, p=.057).Conclusions: AID lead to large improvements in HbA1c of around 15 mmol/mol in patients with poor glycaemic control. Significant improvements in HbA1c are also achieved in patients with an HbA1c close to target. The beneficial effects in TBR are more prominent in patients with lower HbA1c.}, issn = {1520-9156} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kerezoudievangelian_2025_1, title = {Effects of In Vitro Fermented Pleurotus eryngii on Intestinal Barrier Integrity and Immunomodulation in a Lipopolysaccharide-Induced Colonic Model}, author = {Kerezoudi, Evangelia N. and Saxami, Georgia and Zervakis, Georgios I. and Pletsa, Vasiliki and Brummer, Robert Jan and Kyriacou, Adamantini and Rangel, Ignacio}, year = {2025}, journal = {Biomedicines}, volume = {13}, number = {2}, doi = {10.3390/biomedicines13020430}, url = {1940884}, language = {eng}, publisher = {MDPI}, keywords = {pleurotus eryngii; gut barrier function; immune response; lipopolysaccharides; tight junctions}, abstract = {Background: This study investigates the impact of fermentation supernatants (FSs) from Pleurotus eryngii whole mushrooms (PEWS), as well as its subcomponents, digested (PEWSD) and extracted (PEWSE) forms, on intestinal barrier function and immune modulation in lipopolysaccharide (LPS) -stimulated Caco-2 cells.Methods: Gene expression of tight junction (TJs) genes, cytokines, and key immune/metabolic receptors was assessed via qRT-PCR, while cytokine protein levels were measured using ELISA to explore post-transcriptional regulation.Results: LPS challenge significantly downregulated TJs zonula occludens-1 (ZO-1,) occludin, and claudin-1, compromising epithelial integrity. Treatment with FS-PEWS notably restored ZO-1 and occludin expression, outperforming FS-PEWSD and FS-PEWSE, which only partially mitigated the LPS-induced damage. FS-PEWS further demonstrated potent immunomodulatory effects, upregulating anti-inflammatory IL-10 and pro-inflammatory cytokines such as IL-8 and TNF-α. The activation of key receptors like TLR-2 and mTOR suggests that FS-PEWS modulates critical immune and metabolic pathways, such as NF-kB signaling, to maintain immune homeostasis. Although mRNA expression of pro-inflammatory cytokines was altered, no corresponding protein release was detected, suggesting potential post-transcriptional regulation.Conclusions: FS-PEWS preserves intestinal barrier integrity and modulates immune responses, particularly in low-grade inflammation, highlighting the whole food matrix's role in enhancing its bioactivity and functional food potential.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_khoryethong_2025, title = {Effects of long-term oxygen therapy on acute exacerbation and hospital burden : the national DISCOVERY study}, author = {Khor, Yet Hong and Palm, Andreas and Wong, Alyson W. and Guler, Sabina A. and Björklund, Filip and Ahmadi, Zainab and Sundh, Josefin and Ryerson, Christopher J. and Ekström, Magnus}, year = {2025}, journal = {Thorax}, volume = {80}, number = {6}, pages = {378--384}, doi = {10.1136/thorax-2023-221063}, url = {1946419}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {copd exacerbations; hypoxemia; idiopathic pulmonary fibrosis; interstitial fibrosis; long term oxygen therapy (ltot); primary pulmonary hypertension}, abstract = {BACKGROUND: Long-term oxygen therapy (LTOT) improves survival in patients with chronic severe resting hypoxaemia, but effects on hospitalisation are unknown. This study evaluated the potential impact of starting LTOT on acute exacerbation and hospital burden in patients with chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD) and pulmonary hypertension (PH).METHODS: Longitudinal analysis of consecutive patients in the population-based Swedish DISCOVERY cohort who started LTOT between 2000 and 2018 with a follow-up duration≥3 months. Total and hospitalised acute exacerbations of the underlying disease, all-cause hospitalisations, and all-cause outpatient visits were annualised and compared between the year before and after LTOT initiation for each disease cohort, and by hypercapnic status in patients with COPD.RESULTS: Patients with COPD (n=10 134) had significant reduction in annualised rates of total and hospitalised acute exacerbations, as well as all-cause hospitalisations, following LTOT initiation, with increment in those with ILD (n=2507) and PH (n=850). All-cause outpatient visits increased across all cohorts following LTOT initiation. Similar findings were observed in patients with hypercapnic and non-hypercapnic COPD. Sensitivity analyses of patients with 12 months of follow-up showed reduced acute exacerbations and all-cause hospitalisations in the ILD and PH cohorts.CONCLUSION: LTOT is associated with reduced rates of both total and hospitalised acute exacerbations and all-cause hospitalisations in patients with COPD, as well as patients with ILD and PH with 12 months of follow-up. There is increased all-cause outpatient visits in all disease groups following LTOT initiation.}, issn = {0040-6376} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_singhramanjit_2025_1, title = {Effects, Safety, and Treatment Experience of Advanced Hybrid Closed-Loop Systems in Clinical Practice Among Adults Living With Type 1 Diabetes}, author = {Singh, Ramanjit and Imberg, Henrik and Ahmadi, Shilan Seyed and Hallström, Sara and Jendle, Johan and Tengmark, Bengt-Olov and Folino, Anna and Marie, Ekström and Lind, Marcus}, year = {2025}, journal = {Journal of Diabetes Science and Technology}, volume = {19}, number = {6}, pages = {1598--1607}, doi = {10.1177/19322968241242386}, url = {1852384}, language = {eng}, publisher = {Diabetes Technology Society}, keywords = {advanced hybrid closed loop; patient-reported outcome; time in range; type 1 diabetes}, abstract = {BACKGROUND: There are few studies providing a more comprehensive picture of advanced hybrid closed-loop (AHCL) systems in clinical practice. The aim was to evaluate the effects of the AHCL systems, Tandem® t: slim X2™ with Control IQ™, and MiniMed™ 780G, on glucose control, safety, treatment satisfaction, and practical barriers for individuals with type 1 diabetes.METHOD: One hundred forty-two randomly selected adults with type 1 diabetes at six diabetes outpatient clinics in Sweden at any time treated with either the Tandem Control IQ (TCIQ) or the MiniMed 780G system were included. Glycated hemoglobin A1c (HbA1c) and glucose metrics were evaluated. Treatment satisfaction and practical barriers were examined via questionnaires.RESULTS: Mean age was 42 years, median follow-up was 1.7 years, 58 (40.8%) were females, 65% used the TCIQ system. Glycated hemoglobin A1c was reduced by 0.6% (6.8 mmol/mol; 95% confidence interval [CI] = 0.5-0.8% [5.3-8.2 mmol/mol]; P < .001), from 7.3% to 6.7% (57-50 mmol/mol). Time in range (TIR) increased with 14.5% from 57.0% to 71.5% (95% CI = 12.2%-16.9%; P < .001). Time below range (TBR) (<70 mg/dL, <3.9 mmol/L) decreased from 3.8% to 1.6% (P < .001). The standard deviation of glucose values was reduced from 61 to 51 mg/dL (3.4-2.9 mmol/L, P < .001) and the coefficient of variation from 35% to 33% (P < .001). Treatment satisfaction increased, score 14.8 on the Diabetes Treatment Satisfaction Questionnaire (DTSQ) (change version ranging from -18 to 18, P < .001). Four severe hypoglycemia events were detected and no cases of ketoacidosis. Skin problems were experienced by 32.4% of the study population.CONCLUSIONS: Advanced hybrid closed-loop systems improve glucose control with a reasonable safety profile and high treatment satisfaction. Skin problems are common adverse events.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_trindadeines_2025, title = {Efficacy and cost-effectiveness of an ACT and compassion-based intervention for women with breast cancer : study protocol of two randomised controlled trials 1}, author = {Trindade, Ines and Soares, Andreia and Skvarc, David and Carreiras, Diogo and Pereira, Joana and Lourenço, Óscar and Sampaio, Filipa and de Sousa, Bruno and Martins, Teresa C. and Boaventura, Paula and Marta-Simões, Joana and Moreira, Helena}, year = {2025}, journal = {Trials}, volume = {26}, number = {1}, doi = {10.1186/s13063-024-08626-4}, url = {1925771}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {acceptance and commitment therapy; breast cancer; compassion-focused therapy; mind programme; randomised controlled trial}, abstract = {BACKGROUND: Breast cancer is the most diagnosed cancer in women worldwide and carries a considerable psychosocial burden. Interventions based on Acceptance and Commitment Therapy (ACT) and compassion-based approaches show promise in improving adjustment and quality of life in people with cancer. The Mind programme is an integrative ACT and compassion-based intervention tailored for women with breast cancer, which aims to prepare women for survivorship by promoting psychological flexibility and self-compassion. A pilot study of the Mind programme has shown acceptability and preliminary efficacy in improving quality of life and psychological health. This paper presents the study protocol of two randomised controlled trials that aim to test the efficacy and cost-effectiveness of an optimised version of the Mind programme in women with breast cancer.METHODS: Participants will be women diagnosed with breast cancer randomly assigned to the Mind programme or a support group intervention (active control) in a 1:1 ratio for study 1, while study 2 includes one more arm (treatment as usual; inactive control) and a 2:2:1 ratio. Both interventions will be delivered weekly via an 8-session face-to-face or online group format. Data will be collected at baseline, post-treatment and 6-month follow-up. The efficacy and cost-effectiveness of the two interventions will be assessed. Treatment outcomes will comprise cancer-specific quality of life (primary outcome), anxiety and depressive symptoms, psychological flexibility, self-compassion, health-related quality of life, resource use, and intervention's acceptability and feasibility. Study 1 will also include immunological and epigenetic markers associated with breast cancer prognosis and mental health. Outcome assessors will be blind to group allocation. Statistical analyses will be conducted using an intention-to-treat approach. Analyses of moderators and mediators of change will also be performed.DISCUSSION: These trials examine the efficacy and cost-effectiveness of an integrative ACT and compassion-based intervention tailored for women with breast cancer. Greater improvements in psychosocial, biological and resource use are expected in the Mind group, when compared to the control group(s). Results will likely support the potential benefits of the Mind programme for breast cancer patients and highlight the clinical relevance of integrative and holistic interventions in oncology.TRIALS REGISTRATION 2A, 2B: ClinicalTrials.gov NCT05642897 and NCT06212414. Registered on December 8, 2022, and January 18, 2024.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sturmandreas_2025, title = {Efficacy and safety of mirikizumab as induction and maintenance treatment in ≥60-year-old adults with moderately-to-severely active ulcerative colitis}, author = {Sturm, Andreas and Sebastian, Shaji and Faye, Adam and Armuzzi, Alessandro and Buisson, Anthony and Halfvarson, Jonas and Zeissig, Sebastian and Kochar, Bharati and Maier, Sebastian and Redondo, Isabel and Moses, Richard and Keohane, Anthony and Watanabe, Kenji}, year = {2025}, journal = {Gut}, volume = {74}, number = {Suppl. 1}, pages = {A248--A249}, doi = {10.1136/gutjnl-2025-BSG.397}, url = {2001521}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, abstract = {Introduction: Mirikizumab (MIRI), an anti-IL-23p19 antibody, has demonstrated efficacy and safety in adults with moderately-to-severely active ulcerative colitis (UC) in two Phase 3 trials (LUCENT-1/-2; NCT03518086, NCT03524092). As novel therapies for UC are not well studied in adults ≥60 years (older adults), we aimed to evaluate the efficacy and safety of MIRI compared to placebo (PBO) during induction and maintenance treatment among this especially vulnerable subgroup of patients with UC.Methods: In LUCENT-1, patients with UC were randomized to receive 3 intravenous (IV) doses of 300mg MIRI or PBO every four weeks (Q4W) at W0, W4, and W8. In LUCENT-2, responders to MIRI induction at W12 were re-randomized to subcutaneous (SC) 200mg MIRI or PBO Q4W for another 40 weeks (until W52 of continuous treatment). Endpoints evaluated in this post-hoc analysis included clinical response, clinical remission, symptomatic remission, endoscopic remission, corticosteroid (CS)-free remission (W52 only), histologic-endoscopic mucosal improvement (HEMI), histologic-endoscopic mucosal remission (HEMR), and bowel urgency (clinically meaningful improvement and remission). Efficacy in the subgroup of older adults was assessed at W12 and W52 using Fisher’s Exact tests. Safety data were summarized among patients aged 60 and older who received at least one dose of study treatment.Results: At LUCENT-1 baseline, 13.3% of patients (n=154/1162) were ≥60 years, with a median age of 65 [Quartile (Q)1: 62.0, Q3: 69]. Apart from higher prevalence of comorbidities, longer disease duration, older age at diagnosis, and lower frequency of concomitant treatment with thiopurines, the baseline demographics and characteristics were similarto the overall patient population, including disease activity (per modified Mayo Score and Mayo Endoscopic Subscore), disease extent, and prior advanced therapy failure. At W12 and W52, a significantly greater proportion of older adults treated with MIRI vs. PBO achieved clinical response and symptomatic remission. While the studies were not powered to detect differences between MIRI and PBO in this subgroup, there were numerically higher response rates for MIRI vs. PBO for all other outcomes. The safety profile for MIRI in older patients was consistent with the overall study population. There were no deaths and no discontinuations due to adverse events among MIRI-treated older adults.Conclusion: Mirikizumab induced and maintained clinical response and was well tolerated in patients 60 years of age and older with moderately-to-severely active UC.}, issn = {0017-5749} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sturma_2025, title = {Efficacy and safety of mirikizumab as induction and maintenance treatment in adults 60 years or older with moderately to severely active ulcerative colitis}, author = {Sturm, A. and Sebastian, S. and Faye, A. S. and Armuzzi, A. and Buisson, A. and Halfvarson, Jonas and Zeissig, S. and Kochar, B. and Maier, S. and Redondo, I and Moses, R. E. and Keohane, A. and Watanabe, K.}, year = {2025}, journal = {Journal of Crohn's & Colitis}, volume = {19}, number = {Suppl. 1}, pages = {i2005--i2006}, doi = {10.1093/ecco-jcc/jjae190.1263}, url = {1936114}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background: Mirikizumab (MIRI), an anti-IL-23p19 antibody, has demonstrated efficacy and safety in adults with moderately to severely active ulcerative colitis (UC) in two Phase 3 trials (LUCENT-1/-2; NCT03518086, NCT03524092). [1] As novel therapies for UC are not well studied in adults ≥60 years (older adults), we aimed to evaluate the efficacy and safety of MIRI compared to placebo (PBO) during induction and maintenance treatment among this especially vulnerable subgroup of patients with UC. [2. 3].Methods: In LUCENT-1, patients with UC were randomized to receive 3 intravenous (IV) doses of 300mg MIRI or PBO every four weeks (Q4W) at W0, W4, and W8. In LUCENT-2, responders to MIRI induction at W12 were re-randomized to subcutaneous (SC) 200mg MIRI or PBO Q4W for another 40 weeks (until W52 of continuous treatment). Endpoints evaluated in this post-hoc analysis included clinical response, clinical remission, symptomatic remission, endoscopic remission, corticosteroid (CS)-free remission (W52 only), histologic-endoscopic mucosal improvement (HEMI), histologic-endoscopic mucosal remission (HEMR), and bowel urgency (clinically meaningful improvement and remission). Efficacy in the subgroup of older adults was assessed at W12 and W52 using Fisher’s Exact tests. Safety data were summarized among patients aged 60 and older who received at least one dose of study treatment.Results: At LUCENT-1 baseline, 13.3% of patients (n=154/1162) were ≥60 years, with a median age of 65 [Quartile (Q)1: 62.0, Q3: 69]. Apart from higher prevalence of comorbidities, longer disease duration, older age at diagnosis, and lower frequency of concomitant treatment with thiopurines, the baseline demographics and characteristics were similar to the overall patient population, including disease activity (per modified Mayo Score and Mayo Endoscopic Subscore), disease extent, and prior advanced therapy failure. At W12 and W52, a significantly greater proportion of older adults treated with MIRI vs. PBO achieved clinical response and symptomatic remission (Table 1). While the studies were not powered to detect differences between MIRI and PBO in this subgroup, there were numerically higher response rates for MIRI vs. PBO for all other outcomes. The safety profile for MIRI in older patients was consistent with the overall study population. There were no deaths and no discontinuations due to adverse events among MIRI-treated older adults (Table 2).Conclusion: Mirikizumab induced and maintained clinical response and was well tolerated in patients 60 years of age and older with moderately to severely active UC.References:1)D’Haens G, Dubinsky M, Kobayashi T, et al. Mirikizumab as Induction and Maintenance Therapy for Ulcerative Colitis [published correction appears in N Engl J Med. 2023 Aug 24;389(8):772. doi: 10.1056/NEJMx230004]. N Engl J Med. 2023;388(26):2444-2455. doi:10.1056/NEJMoa22079402)Ananthakrishnan AN, Nguyen GC, Bernstein CN. AGA Clinical Practice Update on Management of Inflammatory Bowel Disease in Elderly Patients: Expert Review. Gastroenterology. 2021;160(1):445-451. doi:10.1053/j.gastro.2020.08.0603)Sturm A, Maaser C, Mendall M, et al. European Crohn’s and Colitis Organisation Topical Review on IBD in the Elderly. J Crohns Colitis. 2017;11(3):263-273. doi:10.1093/ecco-jcc/jjw188}, issn = {1873-9946} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_arnonedanilo_2025_1, title = {Efficacy of Lamotrigine in the Treatment of Unipolar and Bipolar Depression : Meta-Analysis of Acute and Maintenance Randomised Controlled Trials}, author = {Arnone, Danilo and Östlundh, Linda and Mosa, Meena and MacDonald, Brianne and Oldershaw, Jonathan and Qassem, Tarik and Young, Allan H.}, year = {2025}, journal = {Pharmaceuticals}, volume = {18}, number = {10}, doi = {10.3390/ph18101590}, url = {2010451}, language = {eng}, publisher = {MDPI}, keywords = {bipolar; bipolar disorder; depression; lamotrigine; major depressive disorders; mood stabilisers; unipolar disorder}, abstract = {Background/Objectives: Lamotrigine has been widely investigated in the treatment and prevention of the emergence of symptoms of depression in unipolar and bipolar depression. This work systematically appraises published and unpublished double-blind randomised controlled trials of lamotrigine to provide up-to-date guidance on the use of lamotrigine in the presence of depressive symptoms.Methods: Systematic searches identified 32 randomised controlled trials, of which 24 were included in the meta-analysis, involving 2257 patients and 2320 controls.Results: Evidence supports the use of lamotrigine in the acute phase of bipolar depression in monotherapy vs. placebo (SMD: 0.155; CI: 0.005-0.305) in the absence of significant heterogeneity and small study effects. In the prophylaxis of bipolar depression, lamotrigine reduced the risk of the emergence of depressive symptoms (RR: 0.78; CI: 0.63, 0.98) and prolonged the duration of symptoms survival (RR: 1.59; CI: 1.19, 2.11) compared to placebo, with no evidence of publication and small study bias. Lamotrigine was not found to be superior to lithium in the acute treatment and prophylaxis of bipolar depression. In the treatment of unipolar depressive episodes, with the inclusion in the analyses of three unpublished studies, lamotrigine was not superior to placebo in monotherapy and as adjunct treatment. There were no maintenance studies in unipolar depression.Conclusions: There is evidence supporting the use of lamotrigine in monotherapy as acute and prophylactic treatment of bipolar depression. Evidence of the use of lamotrigine in unipolar disorders is lacking.PROSPERO registration ID: CRD42025633709.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zetterberghedvig_2025, title = {Efficacy of neck-specific exercises with and without internet-based support on psychological factors in chronic whiplash-associated disorders : Secondary analyses of a randomized controlled trial}, author = {Zetterberg, Hedvig and Boersma, Katja and Peolsson, Anneli and Peterson, Gunnel}, year = {2025}, journal = {Pain medicine}, doi = {10.1093/pm/pnaf179}, url = {2024449}, language = {eng}, publisher = {Oxford University Press}, keywords = {whiplash associated disorder; internet-based intervention; neck-specific exercise; psychological outcomes; randomized controlled trial}, abstract = {OBJECTIVE: Chronic whiplash-associated disorders (WAD) may involve complex interactions between physical symptoms and psychological factors, and long-term effects of exercise programs are of interest. This study aimed to evaluate the effects of a predominantly internet-based neck-specific exercise program (NSEIT) compared with the same exercises (NSE) performed at a physiotherapy clinic on psychological outcomes in chronic WAD, including cognitive-behavioral factors (pain catastrophizing, fear-avoidance beliefs, self-efficacy), emotional distress (symptoms of depression, anxiety), and cognitive functioning. A further objective was to assess whether psychological factors moderated treatment effects on the primary outcome, neck-specific disability.METHODS: This secondary analysis was based on a randomized multicenter trial. Participants (n = 140) were randomized to NSEIT or NSE. Outcomes were assessed at baseline, 3-months, and 15-months. Psychological outcomes were analyzed using mixed design analysis of variance. Moderation effects were tested by adding interaction terms (psychological factor x group) in linear regression models of neck-specific disability.RESULTS: No significant group differences or group x time interactions were found for psychological outcomes. However, there were significant main effects of time for cognitive-behavioral factors and emotional distress in both groups (all P < 0.01), with small to intermediate effect sizes. Psychological factors did not moderate the treatment effects on neck-specific disability.CONCLUSION: The internet-based format (NSEIT), involving fewer clinical visits, did not differ from the more comprehensive physiotherapist-led program (NSE) regarding psychological outcomes. Improvements in cognitive-behavioral factors and emotional distress occurred over time in both groups. The internet-based format might be suitable regardless of psychological characteristics at baseline.}, issn = {1526-2375} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wilandpiotr_2025, title = {Efficacy, Safety, and Immunogenicity of SDZ-ADL, an Adalimumab Biosimilar, in Biologic-Naïve and Switched Patients with Immune-Mediated Inflammatory Diseases : A Literature Review}, author = {Wiland, Piotr and Both, Charlotte and Gaylis, Norman B. and Cohen, Russell D. and Halfvarson, Jonas and Lemke, Lena and von Richter, Oliver and Blauvelt, Andrew}, year = {2025}, journal = {Advances in Therapy}, volume = {42}, number = {3}, pages = {1360--1392}, doi = {10.1007/s12325-024-03098-z}, url = {1935126}, language = {eng}, publisher = {Springer}, keywords = {adalimumab; arthritis; biosimilar; gp2017; hyrimoz; inflammatory bowel disease; psoriasis; sandoz-adalimumab; spondyloarthritis}, abstract = {Sandoz-adalimumab (SDZ-ADL; Hyrimoz®, GP2017) is an adalimumab (ADL) biosimilar approved for the treatment of immune-mediated inflammatory diseases. Here, we review the available literature on SDZ-ADL from controlled and real-world evidence studies. A literature search was carried out to identify articles published up to July 2023 reporting data on efficacy, safety, immunogenicity, and treatment retention rates for SDZ-ADL. In randomized clinical trials, the efficacy, safety, and immunogenicity of SDZ-ADL were comparable to those observed for reference-adalimumab (ref-ADL) and not altered after single or multiple drug switches. Real-world studies confirmed the effectiveness and safety of treatment initiation with SDZ-ADL and of switching to SDZ-ADL from ref-ADL or from other ADL biosimilars. This literature review provides evidence that SDZ-ADL is as effective and safe as ref-ADL in both biologic-naïve and biologic-experienced patients.}, issn = {0741-238X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_garcarudolphalejandro_2025_1, title = {Efficiency of telerehabilitation on subacute stroke ambulation : a matched case-control study}, author = {García-Rudolph, Alejandro and Wright, Mark Andrew and Teixidó, Claudia and Opisso, Eloy and Cedersund, Gunnar and Medina, Josep}, year = {2025}, journal = {Brain impairment : a multidisciplinary journal of the Australian Society for the Study of Brain Impairment}, volume = {26}, doi = {10.1071/IB24032}, url = {1926118}, language = {eng}, publisher = {Cambridge University Press}, keywords = {ambulation; functional; matched case-control; motor recovery; rehabilitation outcomes; stroke; subacute; telerehabilitation}, abstract = {Background: Stroke now represents the condition with the highest need for physical rehabilitation worldwide, with only low or moderate-level evidence testing telerehabilitation compared to in-person care. We compared functional ambulation in subacute patients with stroke following telerehabilitation and matched in-person controls with no biopsychosocial differences at baseline.Methods: We conducted a matched case-control study to compare functional ambulation between individuals with stroke following telerehabilitation and in-person rehabilitation, assessed using the Functional Ambulation Categories (FAC) and the Functional Independence Measure™ (FIM).Results: The telerehabilitation group (n =38) achieved significantly higher FAC gains (1.5 (1.3) vs 1.0 (1.0)) than the in-person rehabilitation group, with no differences in ambulation efficiency, in individuals: admitted to rehabilitation within 60 days after stroke onset; aged 49.8 (±11.4) years at admission; 55.3% female sex; moderate stroke severity; 42.1% with 'good' motor FIM at baseline; mostly living with sentimental partner (73.7%); with 21.1% holding an university education degree.Conclusions: The groups showed no significant differences in ambulation efficiency, though the telerehabilitation group achieved higher FAC gains. Our results suggest that home telerehabilitation can be considered a good alternative to in-person rehabilitation when addressing ambulation in patients with moderate stroke severity and whose home situation mostly includes a cohabiting partner.}, issn = {1443-9646} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_landbergsa_2025, title = {Efter barnförhöret – vad ser forskningen för utmaningar när modellen ska implementeras?}, author = {Landberg, Åsa and Andersson, Emma and Thunberg, Sara and Thulin, Johanna}, year = {2025}, url = {1948842}, language = {swe}, abstract = {Modellen Efter barnförhöret är utvecklad för barn som går hem till föräldrar som är misstänkta för barnmisshandel direkt efter ett barnförhör hos polisen. Modellen har fått stor spridning genom utbildningar i Stiftelsen Allmänna Barnhusets regi. När modellen har implementerats har det lett till lokala anpassningar och förändringar av modellen. Utifrån aktuell forskning diskuteras vad dessa lokala anpassningar innebär för barn och föräldrar och vad gränsen går för att förändringarna blir så stora att man inte längre kan säga att man arbetar enligt Efter barnförhöret. Diskussionen utgår från exemplet med modellen Efter barnförhöret, men berör implementering av nya metoder och modeller i socialt arbete i allmänhet.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_arnisontor_2025, title = {Electroconvulsive Therapy in the Oldest-Old Patients With Depression : Response and Remission Rates, Prognostic Factors, Adverse Events and Mortality}, author = {Arnison, Tor and Eriksson, Alina and Nordenskjöld, Axel}, year = {2025}, journal = {The American journal of geriatric psychiatry}, volume = {33}, number = {10}, pages = {1065--1076}, doi = {10.1016/j.jagp.2025.06.013}, url = {1983533}, language = {eng}, publisher = {Elsevier}, keywords = {electroconvulsive therapy; adverse events; geriatric psychiatry; oldest-old; remission; response}, abstract = {OBJECTIVES: Depression is common in the oldest-old population (aged ≥85 years), a population in which research is lacking and the effects of psychopharmacological treatment may be adverse. Electroconvulsive therapy (ECT) appears to be well tolerated by older patients with depression; however, it is used rarely in clinical practice and research concerning the oldest-old is lacking. The objective of this study was to assess response and remission rates, as well as adverse effects, in oldest-old depressed patients treated with ECT.METHODS: This was a nationwide Swedish register study including 522 oldest-old patients treated with ECT for depression. Two propensity score matched control groups were also included: young patients treated with ECT, and oldest-old depressed patients not treated with ECT. Response and remission rates, clinician-reported adverse events, prognostic factors (including comorbid diseases and treatment parameters), adverse events requiring hospitalization, as well as deaths within 1 week from discharge, were assessed.RESULTS: The oldest-old receiving ECT reported higher response (81.2%) and remission (53.3%) rates than younger counterparts (67.4% versus 27.4%, respectively). Severe psychotic depression was the only prognostic factor for response and remission. The oldest-old experienced fewer adverse events, most commonly confusion and cardiovascular complications, compared to controls. Compared with oldest-old patients not receiving ECT, the ECT group had fewer hospitalizations following discharge.CONCLUSION: ECT is a viable treatment option for oldest-old patients with depression, who show higher response and remission rates than younger patients, as well as fewer hospitalizations than oldest-old patients not treated with ECT.}, issn = {1064-7481} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bertoldibridgetm_2025, title = {Electrodermal reactivity in an aversive countdown task : Concurrent and prospective relations with triarchic psychopathy traits and antisocial behavior outcomes in a child-aged sample}, author = {Bertoldi, Bridget M. and Patrick, Christopher J. and Yancey, James R. and LaManna, Rachel and Tuvblad, Catherine and Oskarsson, Sofi and Baker, Laura A. and Raine, Adrian and Fowles, Don}, year = {2025}, journal = {Frontiers in Psychiatry}, volume = {16}, doi = {10.3389/fpsyt.2025.1680358}, url = {2023827}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {antisocial behavior; longitudinal; psychopathy; skin conductance; triarchic traits}, abstract = {INTRODUCTION: Considerable evidence exists for reduced electrodermal reactivity to aversive cues/events in high-psychopathic individuals, but most research of this kind has employed adult samples and cross-sectional designs. The current study examined skin conductance (SC) activation during anticipation of and in response to a noise stressor in a sample of 9-10 year old children in relation to constituent traits of psychopathy described by the triarchic model (i.e., boldness, disinhibition, meanness), both concurrently and at a five-year follow-up, and in relation to antisocial behavior at the follow-up.METHODS: Participants were 1,082 children from the greater Los Angeles area who underwent successive waves of testing in a longitudinal twin project. Current study analyses focused on (a) SC from the noise stressor task and parental ratings of children's triarchic traits collected at wave 1 of the project (W1; ages 9-10), and (b) parent- and child-ratings of the triarchic traits along with child-reported engagement in aggressive and nonaggressive antisocial behavior (ASB) collected at wave 3 (W3; ages 14-15).RESULTS: Reduced SC reactivity in the noise-stressor task at W1 was related to parent-rated boldness both concurrently (at W1) and prospectively (at W3), but not to parent-rated disinhibition or meanness at either wave. Interestingly, reduced SC reactivity at W1 showed associations with both boldness and meanness as rated by child participants themselves at W3. Additionally, reduced W1 SC reactivity was uniquely predictive of child-reported nonaggressive ASB at W3, whereas W1 parent-rated boldness was uniquely predictive of child-reported aggressive behavior at W3.DISCUSSION: Our finding of an inverse relationship between SC reactivity and parent-rated boldness at W1 corroborates evidence from prior adult research and points to low fear (threat sensitivity) as the basis of deficient stress responding in psychopathy. The finding of contrasting predictive relations for W1 SC reactivity and W1 parent-rated boldness with ASB at W3 suggests differing roles for elements of threat sensitivity tapped by each (e.g., low anxiousness versus social dominance) in nonaggressive versus aggressive forms of ASB. Our findings highlight the nuances of dispositional fearlessness as construct of relevance to psychopathy and suggest important avenues for future research.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dasarinagamalleswararao_2025, title = {Electron-magnon dynamics triggered by an ultrashort laser pulse : A real-time dual GW study}, author = {Dasari, Nagamalleswararao and Strand, Hugo U. R. and Eckstein, Martin and Lichtenstein, Alexander I. and Stepanov, Evgeny A.}, year = {2025}, journal = {Physical Review B}, volume = {111}, number = {23}, doi = {10.1103/vglv-2rmv}, url = {1985818}, language = {eng}, publisher = {American Physical Society}, abstract = {Ultrafast irradiation of correlated electronic systems triggers complex dynamics involving quasiparticle excitations, doublons, charge carriers, and spin fluctuations. To describe these effects, we develop an efficient nonequilibrium approach, dubbed D-GW, that enables a self-consistent treatment of local correlations within dynamical mean-field theory (DMFT) and spatial charge and spin fluctuations that are accounted for simultaneously within a diagrammatic framework. The method is formulated in the real-time domain and provides direct access to single-and two-particle momentum-and energy-dependent response functions without the need for analytical continuation, which is required in Matsubara frequency-based approaches. We apply the D-GW method to investigate the dynamics of a photoexcited extended Hubbard model, the minimal system that simultaneously hosts strong charge and spin fluctuations. Focusing on the challenging parameter regime near the Mott transition, we demonstrate that correlated metals and narrow-gap Mott insulators undergo distinct thermalization processes involving complex energy transfer between single-particle and collective electronic excitations.}, issn = {2469-9950} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zeinermichaela_2025_1, title = {Elemental Analysis and Chemometric Assessment of Edible Part and Peel of Mango Fruits (Mangifera indica L.)}, author = {Zeiner, Michaela and Mihalić, Ema and Juranović Cindrić, Iva and Nemet, Ivan and Fiedler, Heidelore}, year = {2025}, journal = {Foods}, volume = {14}, number = {17}, doi = {10.3390/foods14173096}, url = {1997778}, language = {eng}, publisher = {MDPI}, keywords = {icp-ms; classification; correlation analysis; mango; metals and metalloids; microwave-assisted digestion}, abstract = {Mango (Mangifera indica L.) is a very popular tropical drupe that can be consumed fresh or dried. It is rich in essential nutrients such as vitamins, dietary fibre, and minerals, as well as biologically active substances, with a positive effect on health. However, it can also contain potentially toxic elements, which justifies the need of properly investigating this food product. Commercially available samples of dried mango, as well as the mesocarp and peel of fresh mango, were analysed. Prior to the multi-element analysis by inductively coupled plasma mass spectrometry (ICP-MS), the microwave-assisted sample digestion method using various reagents and reagent mixtures was optimised, showing that a mixture of nitric acid and hydrogen peroxide gave the best recoveries. The results obtained were processed by chemometric methods. The content of elements in the peel was higher than in the mesocarp. The macroelements Ca, K, Mg, and Na were found in the largest proportion, and the micronutrients present in significant quantities were Cu, Zn, and Mn (>3 mg/kg), while toxic elements, which according to the guidelines of The European Food Safety Authority) would represent a danger to human health, were not found in mass fractions above the permissible values.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zeinermichaela_2025_2, title = {Elemental composition of ginger (Zingiber officinale L.) – Analytical approach and assessment of 29 analytes according to classification approaches}, author = {Zeiner, Michaela and Fiedler, Heidelore and Toma, Doris and Nemet, Ivan and Juranović Cindrić, Iva}, year = {2025}, journal = {Microchemical Journal}, volume = {212}, doi = {10.1016/j.microc.2025.113333}, url = {1946449}, language = {eng}, publisher = {Elsevier}, keywords = {acidic digestion; correlation analysis; icp-ms; metals and metalloids}, abstract = {Ginger (Zingiber officinale L.) is a widely used spice which beyond nutritional properties exhibit therapeutic properties. It is sold fresh or dried. In order to characterize this food more in detail, the content of 29 elements in ginger was determined by inductively coupled plasma mass spectrometry (ICP-MS). The either fresh or dry powdered products, were bought in (super)markets in Zagreb (Croatia) and Örebro (Sweden) in either loose form or packaged in plastic or glass. For analysis, all samples were dried and homogenised prior to digestion using nitric acid and hydrogen peroxide. The content of metals and metalloids, grouped according to their orbitals (“block”) and definitions as “toxic”, bioavailability, and Geochem, was assessed. Most abundant element found in all samples was K (2940 mg/kg – 50500 mg/kg), followed by Mg (1080 mg/kg – 3680 mg/kg), Ca (786 mg/kg – 2240 mg/kg), Mn (18.6 mg/kg – 789 mg/kg), Na (52 mg/kg – 987 mg/kg), Al (6.09 mg/kg – 1070 mg/kg), and Fe (32.1 mg/kg – 779 mg/kg). Metals founds in the earth-crust are correlated in the ginger products, which suggests similar uptake pattern. Statistical analysis showed that the origin of the samples as well processing method (drying, grinding) have an impact on the elemental pattern in ginger, whilst no correlation between packaging material (none, glass, plastic) and elemental contents in the products was found.}, issn = {0026-265X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_runstrmedengunilla_2025, title = {Elevated concentrations of methyl isocyanate and isocyanic acid in cigarette smoke}, author = {Runström Eden, Gunilla and Johansson, Anders and Tinnerberg, Håkan and Torén, Kjell and Karlsson, Daniel and Andersson, Lena}, year = {2025}, journal = {Environmental Science and Pollution Research}, volume = {32}, number = {17}, pages = {11016--11023}, doi = {10.1007/s11356-025-36344-0}, url = {1950238}, language = {eng}, publisher = {Springer}, keywords = {cigarette; easysampler; exposure; impinger; isocyanic acid; methyl isocyanate; monoisocyanate; occupational exposure; smoking}, abstract = {Monoisocyanates are usually intermediates of industrial processes but alkyl-isocyanates and isocyanic acid can also be created when nitrogen-containing compounds thermally degrade. One of the most notable monoisocyanates, methyl isocyanate (MIC), was accidentally released to the surrounding from a pesticide plant in the Bhopal disaster of 1984, where it killed several thousand and injured many more (Mishra et al. Int J Occup Med Environ Health 22(3):193-202 2009). MIC is known to have adverse effects on the respiratory system and other mucous membranes. Links between cigarette smoking and exposure to monoisocyanates have been suggested but not properly evaluated. The aim of the present study was to measure isocyanates in direct smoke and exhaled smoke to determine the potential exposure for the smoker and for people inhaling secondhand smoke. Concentrations of isocyanates were determined in direct cigarette smoke from three different generic cigarette brands using Supelco easysampler ASSET EZ4-NCO and impingers with dibutylamine solution in toluene. Exhaled smoke was measured using easysamplers only and one cigarette brand. Both isocyanic acid (ICA) and MIC were found in direct cigarette smoke at high concentrations (MIC 965-12144 µg/m3, ICA 943-5729 µg/m3) using either sampling system. Ethyl isocyanate (EIC) and n-propyl isocyanate (PIC) could also be quantified in direct smoke in all three cigarette brands but at much lower concentrations. Measurements of exhaled smoke found MIC in one sample (5.3 µg/m3) but no quantifiable levels of ICA or other monoisocyanates. Direct inhalation of cigarette smoke leads to high exposure for ICA and MIC, which exceeds levels set for occupational exposure after only a few cigarettes.}, issn = {0944-1344} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_backmanemelie_2025, title = {Elevated Plasma Levels of NET Components in Men with Severe COVID-19 Correlates to Increased Amounts of IL-18}, author = {Backman, Emelie and Gröning, Remigius and Lind, Alicia and Granvik, Christoffer and Eilers, Hinnerk and Lange, Anna and Ahlm, Clas and Cajander, Sara and Forsell, Mattias N. E. and Normark, Johan and Urban, Constantin F.}, year = {2025}, journal = {European Journal of Immunology}, volume = {55}, number = {5}, doi = {10.1002/eji.202451546}, url = {1957605}, language = {eng}, publisher = {Wiley-VCH Verlagsgesellschaft}, keywords = {covid‐19; il‐18; disease severity; neutrophil extracellular traps; sex‐dependent}, abstract = {Severe COVID-19 disease is accompanied by high plasma levels of proinflammatory, prothrombotic NETs, and NET-inducing cytokine IL-18. We found that both, IL-18 and NETs, are elevated in men with severe disease, but not in women of the same category. Our findings warrant further investigation of sex-related differences in SARS-CoV-2 infection.}, issn = {0014-2980} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_primusroberts_2025, title = {Elite Sport is not for Every Body : Navigating Imaginary Positions of Masculine Athlete Bodies}, author = {Primus, Robert S. and Quennerstedt, Mikael and Alsarve, Daniel and Varea, Valeria}, year = {2025}, url = {1959428}, language = {eng}, keywords = {elite sport; masculinity; body; athletes; sport coaches}, abstract = {Sport promotes enjoyment, social interaction, embodied learning, and health. At the same time, it serves as a setting where people learn and navigate certain ideals and norms. Given the physical nature of sport, body norms and their impact on performance are particularly central. These body norms are intrinsically linked to gender norms. Most sports follow a binary structure, categorizing athletes as male or female, shaping expectations of how bodies should look and perform. Coaches play a key role in reinforcing these norms. For example, they have been shown to encourage weight-controlling behaviors and demand extreme weight loss, arguing that it enhances performance. Research on the athlete’s body and its role in body-critical coaching practices has primarily focused on women’s sports. This study aims to provide in-depth knowledge about the positioning of elite athletes as masculine-gendered beings in sports in relation to norms surrounding the masculine body.Building on the importance of the coach, 12 Swedish elite coaches from 9 different sports were interviewed about the role of body weight, shape, and size in their respective sports. Imaginary positions were used as a lens to map and understand norms of the masculine sporting body. Exploring imaginary positions empirically involves analyzing patterns of what are known as practical ideologies—described in this case by sports coaches—and how these ideologies shape what is considered possible or impossible in sport.Elite athletes construct themselves as masculine-gendered beings by navigating five imagined positions: the performing athlete, the fit athlete, the ironic athlete, the social athlete, and the self-regulated athlete. The greatest tension arises between the performing and fit athlete positions, as societal ideals of fitness can conflict with the demands of peak performance. However, in general, these positions largely reinforce one another. Athletes are expected to see their bodies as tools to calibrate, maintaining a detached and carefree attitude. This detachment is expressed through irony, joking about their own and others’ bodies, and being social. Athletes who are introverted or sensitive about their bodies face barriers. Some exceptionally skilled athletes may bypass certain expectations, but few can resist hegemonic masculinities. Interestingly, female athletes, perceived as more sensitive, may challenge norms and influence body ideals in sport.The findings present an argument for sport organisations to reconsider the traditional practice of organizing training along gendered lines. While such an approach is more feasible in individual sports, we encourage team sports to explore opportunities for mixed-gender training sessions as well.Nevertheless, working with mixed-gender groups alone is insufficient. To effectively challenge gendered stereotypes, coaching practices must adopt what Pederson and colleagues (2015) term a “gender-transformative” approach, which involves actively reshaping harmful gender roles and relations. While our study does not provide concrete examples of such practices, we aim to encourage coaches and other key stakeholders to critically engage with gender issues related to the masculine sporting body.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_calatravanicolsfrancisco_2025, title = {Embedded Inter-Subject Variability in Adversarial Learning for Inertial Sensor-Based Human Activity Recognition}, author = {Calatrava Nicolás, Francisco and Miyauchi, Shoko and Fortes Rey, Vitor and Lukowicz, Paul and Stoyanov, Todor and Martínez Mozos, Oscar}, year = {2025}, doi = {10.1109/MLSP62443.2025.11204225}, url = {2015892}, language = {eng}, publisher = {IEEE}, keywords = {human activity recognition; inertial wearable sensors; inter-subject variability; deep adversarial learning}, abstract = {This paper addresses the problem of Human Activity Recognition(HAR) using data from wearable inertial sensors. An important challenge in HAR is the model’s generalization capabilities to new unseen individuals due to inter-subject variability, i.e., the same activity is performed differently by different individuals. To address this problem, we propose a novel deep adversarial frame-work that integrates the concept of inter-subject variability in thead versarial task, thereby encouraging subject-invariant feature representations and enhancing the classification performance in the HAR problem. Our approach outperforms previous methods in three well-established HAR datasets using a leave-one-subject-out (LOSO) cross-validation. Further results indicate that our proposed adversarial task effectively reduces inter-subject variability among different users in the feature space, and it outperforms adversarial tasks from previous works when integrated into our framework.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_heldtcasselsusanna_2025, title = {Embodied intersectionality at work in hotel housekeeping in Sweden}, author = {Heldt Cassel, Susanna and Thulemark, Maria and Duncan, Tara}, year = {2025}, journal = {Gender, Place and Culture: A Journal of Feminist Geography}, doi = {10.1080/0966369X.2025.2589745}, url = {2018199}, language = {eng}, publisher = {Routledge}, keywords = {intersectionality; embodied labour; working participant observation; hotel housekeeping; bodies; sweden}, abstract = {This paper examines the experiences of hotel housekeepers in Sweden, focusing on how their embodied identities, shaped by factors like gender, race, and migration background, influence and are influenced by their work. Placing the body at the centre of our research, we explore how embodied intersectionality is situated and contextually produced as lived experience in hotel workplaces. The way in which intersectional power dimensions are played out and performed is closely interconnected to bodies and the embodiment of roles, duties, identities and expectations inherent in the occupational context of the workplace. Through working participant observation, we explore the daily routines and bodily demands of housekeeping work, a low-status, feminised occupation predominantly filled by women and migrants. Our paper emphasises how embodied intersectionality operates within the workplace, revealing power dynamics, challenges, and subtle forms of resistance enacted by the workers. Our analysis illustrates that the ways in which hotel housekeeping work is carried out is shaped by expectations on what it means to be a housekeeper as much as it is by wider intersectional factors and embodied identities. We conclude by advocating for a greater emphasis on the working body in workplace studies to understand the nuanced realities of such marginalised labourers.}, issn = {0966-369X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tubertinielena_2025, title = {Embracing minority joy : Positive experiences of trans and nonbinary identities}, author = {Tubertini, Elena and Lorusso, Maric Martin and Bittoni, Celeste and Gaboardi, Marta and Lasagna, Camilla and Minerva, Lia and Malmquist, Anna and Wurm, Matilda and Lenzi, Michela and Miscioscia, Marina}, year = {2025}, journal = {Journal of Prevention & Intervention in the Community}, volume = {53}, number = {4}, pages = {691--704}, doi = {10.1080/10852352.2025.2574726}, url = {2008099}, language = {eng}, publisher = {Routledge}, keywords = {codebook thematic analysis; lgbtq+ community; minority joy; positive psychology; transgender health}, abstract = {Past research on trans and nonbinary (TNB) people has primarily addressed minority stress and discrimination. Recently, researchers began to examine the positive dimensions of TNB identities, conceptualizing the construct of "minority joy". The present study aimed to contribute to the theoretical development of this construct by analyzing the experiences of Italian TNB individuals. Data were drawn from two studies exploring the well-being of 12 trans men, 8 trans women and 8 nonbinary individuals (age range = 19-54; mean = 27.5) using semi-structured interviews. Using a codebook thematic analysis, we identified four domains of positive experiences associated with TNB identities: (1) Gender Euphoria from authenticity to recognition; (2) Feeling pride and playing with gender norms; (3) Critical awareness as a form of liberation from norms; (4) Queer Community as a source of individual and collective support. These findings emphasize the role of interventions and prevention strategies promoting gender identity pride, authenticity, and self-affirmation.}, issn = {1085-2352} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zhangchi_2025, title = {Emergence, evolution and temporal spread of ceftriaxone-resistant Neisseria gonorrhoeae in China from 2002 to 2022 : a retrospective genomic surveillance study}, author = {Zhang, Chi and Yang, Yang and Zhu, Bangyong and Tang, Xiaozheng and Zhong, Na and Wang, Youwei and Zeng, Zhijun and Chen, Huichao and Lu, Xinyi and Zhu, Cansheng and Shadehan, Ruizha and Cao, Wenling and Golparian, Daniel and Gu, Weiming and Unemo, Magnus and Peng, Junping}, year = {2025}, journal = {Emerging Microbes & Infections}, volume = {14}, number = {1}, doi = {10.1080/22221751.2025.2579397}, url = {2008919}, language = {eng}, publisher = {Nature Publishing Group}, keywords = {fc428 clone; neisseria gonorrhoeae; ceftriaxone-resistance; temporal phylogeny; whole-genome sequencing}, abstract = {Resistance to the last treatment option for gonorrhoea, ceftriaxone is a major public health concern globally, which poses a serious threat to the currently recommended ceftriaxone monotherapy. We elucidate the emergence, evolution and temporal spread of ceftriaxone-resistant gonococcal strains in China, using whole-genome sequencing of 357 ceftriaxone-resistant isolates from eight provinces during 2002-2022. We describe distinct differences between ceftriaxone-resistant gonococcal strains in China and global isolates. The resistance levels for the 357 isolates for cefixime, azithromycin, ciprofloxacin, benzylpenicillin, tetracycline, and spectinomycin were 92.4%, 17.0%, 100%, 84.9%, 92.7%, and 0.8%, respectively. Before 2019, ceftriaxone-resistant isolates in China mainly harboured non-mosaic penA alleles like penA-13, penA-12, penA-18 or mosaic penA-10. From 2019, ceftriaxone-resistant isolates with mosaic penA-60.001 increased rapidly, becoming the dominant penA allele. Meanwhile, penA-60.001 was horizontally transferred from MLST ST1903 strains to strains of other MLST STs that were prevalent in China. Notably, the MLST ST7365 isolates with penA-60.001 allele had higher ceftriaxone MICs than isolates of the typical ST1903 FC428 clone. This may be attributed to a main clade of MLST ST7365 strains in China exhibiting elevated ceftriaxone MICs, and the temporal phylogeny showed this clade emerged around 1994. In summary, we reveal the unique genomic and evolutionary patterns of ceftriaxone-resistant gonococcal strains in China, and the 357 not previously reported isolates substantially increase the number of global ceftriaxone-resistant isolates. Our results suggest potential evolutionary pathways and directions of ceftriaxone-resistant strains, and provide valuable data for examining genomic epidemiology, antimicrobial resistance determinants and formulating strategies for surveillance and interventions.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_riahiemna_2025, title = {Employees' information security awareness (ISA) in public organisations : insights from cross-cultural studies in Sweden, France, and Tunisia}, author = {Riahi, Emna and Islam, M. Sirajul}, year = {2025}, journal = {Behavior and Information Technology}, volume = {44}, number = {1}, pages = {79--101}, doi = {10.1080/0144929X.2024.2311734}, url = {1837526}, language = {eng}, publisher = {Taylor & Francis}, keywords = {cross-cultural study; hofstede's national culture model; information security behaviour; tunisia; sweden; france}, abstract = {The dominance of national culture in organisational environments has been widely acknowledged. This study aims to explore the impact of national culture on information security awareness by examining cultural characteristics in the public sector. Drawing on Hofstede's model, a literature review was conducted to analyze existing knowledge and identify cultural traits in selected countries. Empirical data were collected through semi-structured interviews conducted in Sweden, France, and Tunisia. The data were analyzed using the Human Aspects of Information Security (HAIS) model, revealing distinct patterns and emphasising the role of culture in shaping behaviours. The findings underscore the importance of involving Swedish employees in the policy design process to effectively enhance information security awareness. For French employees, it was found that learning from past experiences and respecting hierarchical structures are crucial factors in raising awareness. Conversely, in Tunisia, information security initiatives should take into account the social and relational aspects to promote awareness effectively. These insights provide valuable guidance to managers in multinational organisations, enabling them to comprehend the underlying forces and dynamics in countries with similar characteristics.}, issn = {0144-929X} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_allardalexandra_2025, title = {Employment, Externalities, and Exploitation : Empirical Essays on Maritime Sectors and Renewable Resource Management}, author = {Allard, Alexandra}, year = {2025}, url = {1992319}, language = {eng}, publisher = {Örebro University}, keywords = {european union; blue economy; employment dynamics; fisheries management; policy position; informational lobbying; interest groups; political economy; wind turbines; property values}, abstract = {This thesis addresses empirically understudied and politically significant issues. Specifically, it examines the blue economy and renewable energy, both of which are central to the European Union’s economic and environmental strategies.Essay I examine employment dynamics in the Swedish blue economy, i.e., maritime and maritime-related sectors. By utilizing a novel firmlevel dataset covering 1998–2020, the analysis finds that firms within the blue economy generally exhibit higher employment growth and lower job destruction than their counterparts in other sectors.Essays II and III examine EU fisheries governance. Essay II examines the policy preferences of EU member states, as indicated by bargaining outcomes on Total Allowable Catches (TACs). The findings suggest that the United Kingdom, Ireland, Portugal, Lithuania, and Poland advocate for TACs above scientific advice, while Germany supports lower TACs. Essay III assesses interest group lobbying within the Baltic Sea Advisory Council, demonstrating that fisheries achieve greater lobbying success when scientific advice is more than 20 percent below the status quo or the level of conflict is high. In contrast, other interest groups are more successful when the level of conflict is low and scientific advice is closer to or above the status quo.Finally, Essay IV presents a meta-analysis of 252 estimates from 21 studies on the impact of wind turbines on property values. The results indicate a negative and significant effect on properties located within 4 km of a wind turbine, with stronger effects at closer distances and in more densely populated areas.}, file = {https://oru.diva-portal.org/smash/get/diva2:1992319/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_amourilayan_2025, title = {Empowering Future Practitioners : Collaborative Action Research in Social Work and Psychology Education for Advancing Social Justice}, author = {Amouri, Layan and Giles, C. J. and Baianstovu, Rúna Í and Fredriksson, Matilda and Jönsson, Jessica H.}, year = {2025}, pages = {7--7}, url = {2019900}, language = {eng}, keywords = {social work education; psychology education; participatory education; social justice; student voices; critical pedagogy; globalization; power dynamics}, abstract = {As societies face escalating inequalities, ecological crises, and the erosion of welfare systems, social work and psychology education must evolve to prepare future professionals for complex societal challenges. Despite comprehensive discrimination laws in Sweden, government policy requires only gender mainstreaming to permeate all levels of university work, allowing limited educational focus on broader social justice frameworks. This presentation explores how collaborative and participatory action research (PAR) can foster critical engagement, amplify student voices, and integrate social justice perspectives into social work and psychology education.Drawing on a scoping review of Nordic social work curricula and focus groups with Swedish social work students, significant gaps are revealed in global, structural, and critical perspectives within professional training. While students recognize the importance of addressing systemic injustices, their education primarily emphasizes technical competencies at the expense of deeper engagement with power structures, marginalization, and intersectional inequalities. Similarly, an internal review of LGBTQI+themes in a Swedish psychology program further highlights the dominance of normative, individual-centered approaches. Importantly, students in both subjects describe feeling anxious about their limited knowledge and (in)capacity for critical reflection on the sociopolitical dimensions of mental health, identity, and well-being.This study positions PAR as a model for fostering critical consciousness, student agency ,and collaborative, interdisciplinary knowledge production between social work and psychology students. By centering student experiences and voices, PAR bridges theory and practice, enabling students to co-create their education and critically examine their professional roles. This shift could equip future social workers and psychologists with theoretical and practical tools and strengthen their ability to challenge systemic injustices and drive transformative social change.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ekenjulia_2025, title = {En psykometrisk utvärdering av frågeformuläret Insomnia Severity Index (ISI) hos svenska tonåringar}, author = {Eken, Julia and Nordin, Isac and Norell, Annika}, year = {2025}, journal = {Sömn och Hälsa}, number = {13}, pages = {17--45}, doi = {10.59526/soh.13.39202}, url = {2031509}, language = {swe}, publisher = {Nätverket Sömn och hälsa}, keywords = {adolescents; factor analysis; insomnia; insomnia severity index; psychometric evaluation}, abstract = {Insomnia is a sleep disorder with a high prevalence in teenagers, which leads to suffering and an increased risk of future health problems. The Insomnia Severity Index (ISI) is a validated and well-researched self-report questionnaire that aims to quantifyinsomnia and its severity in adults. It is used in insomnia research and has been translated into many languages, including Swedish. The psychometric properties of the ISI have been thoroughly investigated for adults and to some extent on teenagers abroad, but a psychometric evaluation of a Swedish transla-tion of the ISI with young people in Sweden is still missing. The approach of this study was to evaluate the psychometric properties of the ISI in a sample of Swedish teenagers. A cross-sectional study with data from 205 participants from a larger study was conducted to ascer-tain the reliability of the scale and seek to operationalize its underlying components. The results indicate that the ISI is a reliable self-assess-ment scale for young people in a Swedish context. Furthermore, two components were distinguished by using principal component analysis. The components were operationalized into typical and atypical insom-nia symptoms for teenagers, respectively. The typical symptoms were difficulties falling asleep combined with daytime complaints, while atypical symptoms consisted of difficulties falling asleep after waking up during the night, and difficulties with premature awakenings early in the mornings. The conclusion is that a Swedish translation of the ISI has good psychometric properties in teenagers, and that the underlying structure of the ISI for teenagers differs from what studies on adults have found, and to some extent studies on foreign teenagers. This could reflect age-related differences in sleep, cultural differences or problem-atic phrasing of the Swedish version of the ISI.;Insomni är en sömnstörning med hög prevalens hos ungdomar, vilket leder till lidande och risk för framtida ohälsa. Insomnia Severity Index (ISI) är ett beprövat och väl beforskat självskattningsformulär som syftar till att kvantifiera insomni och dess svårighetsgrad hos vuxna. Det används i insomniforskning och finns översatt till många språk, däribland svenska. De psykometriska egenskaperna hos ISI har undersökts grundligt för vuxna individer och till viss del på tonårigar utomlands men en psykometrisk utvärdering av en svensk översättning av ISI hos ungdomar i Sverige saknas fortfarande. Denna studies ansats var att utvärdera de psykometriska egenskaperna hos ISI i ett urval av svenska tonåringar. En tvärsnittsstudie med data från totalt 205 deltagare från en större studie genomfördes för att utröna skalans reliabilitet samt söka operationalisera dess underliggande komponenter. Resultatet indikerar att ISI är en tillförlitlig självskattningsskala för ungdomar i en svensk kontext. Vidare kunde två komponenter urskiljas med hjälp av principalkomponentanalys. Komponenterna operationaliserades till typiska respektive atypiska insomnisymtom för tonåringar. Det typiska var svårigheter att somna in kombinerat med dagtidsbesvär, medan atypiska symtom bestod av omsomnings-svårigheter och svårigheter med för tidiga uppvaknanden. Slutsatsen är att en svensk översättning av ISI har goda psykometriska egenskaper hos tonåringar, och att den underliggande strukturen hos ISI för ungdomar skiljer sig från vad studier på vuxna funnit, och i någon mån, studier på utländska tonåringar. Detta avspeglar troligen både åldersmässiga skillnader gällande sömn och möjligen även kulturella skillnader.}, issn = {2003-234X}, file = {https://oru.diva-portal.org/smash/get/diva2:2031509/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_aaslanderik_2025, title = {Enacting a new physical education curriculum : a collaborative investigation}, author = {Aasland, Erik and Nyberg, Gunn and Barker, Dean}, year = {2025}, journal = {Sport, Education and Society}, volume = {30}, number = {7}, pages = {841--854}, doi = {10.1080/13573322.2024.2367752}, url = {1885853}, language = {eng}, publisher = {Routledge}, keywords = {curriculum enactment; fullan; educational change; action research; teacher beliefs; teaching culture}, abstract = {Previous research shows that enacting a new curriculum is a complex process. Teachers can be enthusiastic and committed to new curricular objectives, but they can also experience frustration and disappointment. Scholars have suggested that teachers who perceive lack of support, or tensions between their personal philosophies and the educational principles underpinning a new curriculum, struggle to enact new curricula in line with their intent. Our purpose in this article is to illustrate how two Physical Education (PE) teachers experienced the enactment of a new official curriculum. An action research approach was used as design of the study. Researchers cooperated with two PE teachers for 18 months. The empirical material consisted of 50 sets of field notes from the two teachers' teaching lessons, transcripts from one semi-structured qualitative interview with both teachers following the completion of the school year. The material also consisted of reflection logs produced by the teachers containing written notes about their experiences of the curriculum enactment. We used literature on educational change (Fullan, M., & Hargreaves, A. (1991). What's worth fighting fore? Working together for your school. Ontario Public School Teachers' Federation) as our theoretical framework. Our findings show that the teachers experienced the curriculum enactment in contradictory ways. Shifting from previous PE practices that focused on sports activities and emphasized teacher instruction, to pedagogical practices informed by the new PE curriculum (including sociocultural perspectives of learning and assessment), led to uncertainty, surprise, satisfaction, as well as distrust. Our findings also showed that the teachers' experiences of the enactment were influenced by perceived gender biases. We argue that teachers' beliefs and the teaching culture were particularly influential dimensions regarding the two PE teachers' experiences of the curriculum enactment. Practitioners and researchers attempting curriculum enactment in the future should pay careful attention to such dimensions, especially given that tensions and uncertainty often occur during any educational change.}, issn = {1357-3322} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ekstrmmats_2025, title = {Enacting Journalistic Authority : The Communicative Challenges and Competences of Live Two-Way Correspondents in Swedish Public Service Broadcasting}, author = {Ekström, Mats and Kroon, Åsa and Östlund, Emil}, year = {2025}, journal = {Journalism Practice}, volume = {19}, number = {11}, pages = {2497--2514}, doi = {10.1080/17512786.2024.2310045}, url = {1833188}, language = {eng}, publisher = {Routledge}, keywords = {authority; correspondents; epistemic; live two-way; live reporting; broadcast; truth}, abstract = {Whenever a major event flares up in the world, we are bound to be met by correspondents reporting live on the news. The correspondents are typically promoted as authoritative voices. Their live talk is delivered in “the live two-way,” a broadcast interaction between the presenter and the correspondent on location. Focusing on live reporting during the Ukraine–Russia war (2022–), this study analyses the communicative work that goes on in the live two-way, and how correspondents handle the tasks related to the enactments of epistemic authority. A conceptual framework is applied defining the communicative and epistemic dimension of the live two-way. This study applies a discourse approach and focuses on experienced correspondents in Swedish public service. Data consists of 30 live two-ways and interviews with 5 of the journalists about planning and execution of the live reporting. Results show how practices and roles separated in other genres of news are integrated in the complex work of the correspondent who is expected to fluently report from location, convey a sense of being there, present facts, and analyse and explain. This study indicates different styles of reporting when correspondents alternate between a careful and confident stance as they balance their commitments to truth.}, issn = {1751-2786} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lovaneluclia_2025, title = {Endocervical adenocarcinomas and HPV genotyping in an HIV endemic milieu - a retrospective study}, author = {Lovane, Lucília and Lillsunde-Larsson, Gabriella and Tulsidás, Satish and Carrilho, Carla and Andersson, Sören and Karlsson, Christina}, year = {2025}, journal = {BMC Women's Health}, volume = {25}, number = {1}, doi = {10.1186/s12905-025-03555-z}, url = {1928120}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {endocervical adenocarcinomas; hiv; hpv; hpv vaccine; in situ hybridisation}, abstract = {Background: Cervical cancer is the most prevalent cancer in Mozambique, with endocervical adenocarcinoma accounting for approximately 5.5% of cases. Knowledge regarding the most prevalent HPV genotypes in endocervical adenocarcinoma is limited, within this setting. This study aimed to investigate human papillomavirus (HPV) prevalence and genotypes within a cohort of endocervical adenocarcinoma patients in the context of Mozambique's recently introduced vaccination programme, considering the country's HIV-endemic setting.Methods: Forty consecutive cases of endocervical adenocarcinoma diagnosed at Maputo Central Hospital between 2017 and 2018, with limited clinical data available, were included. Human immunodeficiency virus (HIV) status was determined through serological data or in situ hybridisation on histopathological slides. HPV detection was performed using a multi-methodological approach, including Anyplex II, in-house polymerase chain reaction (PCR), and chromogenic and fluorescent in situ hybridisation techniques.Results: All 40 cases exhibited HPV-dependent morphology. Fourteen of the 40 patients were HIV-positive. No significant differences were observed between the two groups regarding age, stage, or histopathological type. hrHPV16, 18, or 45 were detected in all cases. Notably, multiple hrHPV infections were identified exclusively in HIV-negative cases (10/26, p = 0.0075), with hrHPV18/45 co-infection being the most common (n = 8).Conclusions: These findings suggest that the newly implemented quadrivalent vaccination programme has the potential to prevent morbidity and mortality from endocervical adenocarcinoma, irrespective of HIV infection status, in Mozambique's HIV-endemic environment.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sjstrmylva_2025, title = {Endocrine disruption potential of dust in children's indoor environments : Associations with multiple chemicals from various compound classes across exposure matrices used for health risk assessment}, author = {Sjöström, Ylva and Holmes, Breanne and Ricklund, Niklas and Struwe, Nathalie and Hagström, Katja and Hagberg, Jessika and Larsson, Maria}, year = {2025}, journal = {Environmental Research}, volume = {278}, doi = {10.1016/j.envres.2025.121614}, url = {1954968}, language = {eng}, publisher = {Elsevier}, keywords = {indoor dust; bioassay; endocrine disruptive chemicals; relative potencies}, abstract = {Indoor dust contains a complex mixture of chemicals, including endocrine-disrupting chemicals (EDCs), which may pose risks to children's health. As children spend most of their time indoors and have frequent dust contact, their exposure is heightened. This study quantified the endocrine disrupting potential of dust from children's indoor environments in Sweden, and assessed associations with flame retardants and plasticizers in dust, handwipes, and urine.Fifty dust samples from 18 homes and 11 preschool units were analyzed for estrogen, anti-androgen, and thyroid receptor activities using human osteosarcoma cell-based luciferase reporter assays. Associations were evaluated with 21 legacy and 18 emerging halogenated flame retardants (HFRs) and 11 organophosphate esters (OPEs) in dust and handwipes, as well as nine plasticizers (eight phthalates and di-isononyl cyclohexane 1,2-dicarboxylate (DiNCH)) in dust, and 14 plasticizer metabolites in urine. Samples for biological and chemical analyses were collected from the same designated areas within a limited time frame.Most dust samples exhibited estrogen receptor agonist (ER) and androgen receptor antagonistic (anti-AR) activity, while thyroid receptor (TR) induction was low. Preschool dust showed significantly higher estrogenic activity than home dust. No seasonal variation was observed. Associations were observed between dust hormonal activities and urinary plasticizer metabolites, as well as HFR and OPE concentrations in dust and handwipes. Relative potency (REP) analyses of 36 HFRs and OPEs revealed notable anti-AR activity for 2,2´,4,4´-tetrabromodiphenyl ether (BDE-47) (REP values 0.85±0.10 (EC25) and 0.93±0.07 (EC50)) and 2,2´,4,4´,6-pentabromo diphenyl ether (BDE-100) (REP values 2.74±0.29 (EC25) and 3.23±0.42 (EC50)). Additionally, BDE-100 showed low ER induction.}, issn = {0013-9351} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_larsenj_2025, title = {Endovascular management of iatrogenic femoral access site vascular injuries : A case series and literature review}, author = {Larsen, J. and Stene Hurtsén, Anna and McGreevy, David T. and Chwich, J. and Hörer, Tal M. and Gidlund, Khatereh Djavani}, year = {2025}, journal = {JVS-Vascular Insights}, volume = {3}, doi = {10.1016/j.jvsvi.2025.100274}, url = {2028278}, language = {eng}, publisher = {Elsevier}, keywords = {covered stent graft; endovascular repair; femoral artery; hybrid operating rooms; iatrogenic vascular injuries; vascular access complication}, abstract = {Objective: Iatrogenic major vascular injuries at femoral artery access sites are potentially life-threatening complications of endovascular procedures. Although open surgical repair remains the standard treatment, it carries significant morbidity. Endovascular management using covered stent grafts, deployed via a contralateral or ipsilateral approach, presents a minimally invasive alternative in selected cases. This study reports a single-center experience with an endovascular-first strategy and review of relevant published data.Methods: A retrospective single-center observational study was conducted between 2016 and 2024. Patients treated with covered stent grafts for iatrogenic vascular access site injuries, defined as access site-related hemorrhage or pseudoaneurysm involving the external iliac artery, common femoral artery or superficial femoral artery, were included. The most common mechanism of injury requiring stenting was closure device failure. A literature review of published data on PubMed was performed. The primary outcomes assessed were technical success and stent graft patency during follow-up.Results: A total of 20 access site-related vascular injuries were treated using covered stent grafts. Technical success was achieved in 95% (19/20). Stent graft patency was maintained in 100% of cases at 30 days (n = 15) and 1 year (n = 11). The literature review identified 15 studies and a total of 585 patients treated with covered stent grafts with technical success in nearly 100% and preserved stent graft patency throughout a follow-up period ranging from 3 months to a maximum of 3 years in all but a handful of cases.Conclusions: Endovascular repair using covered stent grafts is a viable treatment option for iatrogenic access site vascular injuries of the external iliac, common femoral, and superficial femoral arteries. This approach may be particularly beneficial for frail patients or those with hemodynamic instability. Further studies are needed to confirm long-term outcomes and optimal patient selection. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nikolopoulosdionysis_2025, title = {Enhanced B cell and complement cascade gene signatures in patients with neuropsychiatric systemic lupus erythematosus}, author = {Nikolopoulos, Dionysis and Sentis, George and Kitsios, Iasonas and Garantziotis, Panagiotis and Kapsala, Noemin and Pieta, Antigone and Flouda, Sofia and Manolakou, Theodora and Nikoloudaki, Myrto and Banos, Aggelos and Chavatza, Katerina and Parodis, Ioannis and Filia, Anastasia and Bertsias, George and Fanouriakis, Antonis and Boumpas, Dimitrios T.}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {84}, number = {8}, pages = {1342--1353}, doi = {10.1016/j.ard.2025.04.006}, url = {1957639}, language = {eng}, publisher = {Highwire Press}, abstract = {OBJECTIVES: The management of neuropsychiatric systemic lupus erythematosus (NPSLE) remains challenging because of clinical heterogeneity and the complexity of pathophysiologic mechanisms involved. We sought to determine the molecular signature of NPSLE and its endotypes towards novel biomarkers and targeted therapies.METHODS: Whole-blood RNA sequencing from 308 patients with systemic lupus erythematosus (119 with NPSLE, 189 non-NPSLE) and 72-matched healthy controls (HCs) were performed. Supervised pathway enrichment analysis and unsupervised weighted gene coexpression network analysis were applied to distinguish clinically and molecularly defined NPSLE endotypes.RESULTS: Compared with HCs, patients with NPSLE demonstrated dysregulation of adaptive immune responses along with upregulation of interleukin (IL)-1, IL-6, IL-17, and IL-12/IL-23 signalling pathways. The comparison between NPSLE and non-NPSLE groups revealed a robust upregulation of complement cascade, DNA damage response, adaptive immunity, and IL-1 and IL-6 signalling. Furthermore, active NPSLE exhibited a strong autophagy signature. The B cell and complement cascade signatures exhibited a gradual upregulation across the non-NPSLE, inactive NPSLE, and active NPSLE subgroups. Within NPSLE, diffuse syndromes correlated positively with the oxidative phosphorylation module, while antiphospholipid antibody-positive NPSLE was not associated with specific signatures by unsupervised analysis. NPSLE endotypes such as cognitive dysfunction, seizures, psychosis, and optic neuritis were associated with distinct transcriptomic signatures namely IL-6 signalling and leukocyte migration, DNA damage response, inflammation, and type-I interferon, respectively.CONCLUSIONS: The clinical heterogeneity of NPSLE appears to be associated with molecular diversity, with certain endotypes or syndromes exhibiting distinct gene signatures. Upregulation of adaptive immune response and complement cascade suggests that complement inhibitors and B cell-targeted therapies could be further explored in NPSLE.}, issn = {0003-4967} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_laijianwen_2025, title = {Enhanced low-temperature simultaneous removal of nitrogen oxides and polychlorinated dibenzodioxins and dibenzofurans over vanadium-cerium-tungsten oxide supported on titanium dioxide catalyst : A pilot-scale evaluation}, author = {Lai, Jianwen and Qi, Hongbo and Ma, Yunfeng and Lin, Xiaoqing and Han, Zhongkang and Fiedler, Heidelore and Li, Xiaodong}, year = {2025}, journal = {Journal of Environmental Chemical Engineering}, volume = {13}, number = {4}, doi = {10.1016/j.jece.2025.117353}, url = {1973263}, language = {eng}, publisher = {Elsevier}, keywords = {pcdd/fs; nitrogen oxides; simultaneous removal; low temperature; scr catalysts}, abstract = {Developing a honeycomb catalyst that enables the simultaneous removal of nitrogen oxides and polychlorinated dibenzodioxins/dibenzofurans (PCDD/Fs) below 200 degrees C is crucial for enhancing energy efficiency and advancing flue gas purification in municipal solid waste incineration (MSWI) plants. In this study, the removal efficiencies of a newly developed VOx-CeOx-WOx/TiO2(VWCe, 4.00 wt% V2O5, 2.84 wt% WO3, and 2.77 wt% CeO2, supported on TiO2) catalyst were evaluated through a series of pilot-scale experiments. The VWCe catalyst demonstrated excellent performance, achieving RENOx of 78 %-89 % and REPCDD/Fs of 88 %-96 % in the temperature range of 140-180 degrees C. Multiple characterization techniques revealed that the catalyst exhibited a typical mesoporous structure, enhanced redox properties, attributed to a high proportion of Ce3 + (65.9 %), abundant surface-active species, increased oxygen vacancies, and active lattice oxygen. Density functional theory (DFT) calculations and in-situ diffuse reflectance Fourier transform infrared spectroscopy (DRIFTs) analyses confirmed that CeOx and WOx significantly enhanced the catalyst's acidity, particularly the Br & Oslash;nsted acid sites, which improved its denitrification performance. This study highlights the potential for further improvement of SCR catalysts to achieve efficient simultaneous removal of NOx and PCDD/Fs under low-temperature conditions in real flue gas applications.}, issn = {2213-2929} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vikandermartina_2025_1, title = {Enhancing domestic violence risk assessments with children's perspectives : Exploring risk, vulnerability and protective factors through forensic interviews}, author = {Vikander, Martina and Strand, Susanne}, year = {2025}, journal = {Child & Family Social Work}, volume = {30}, number = {2}, pages = {120--129}, doi = {10.1111/cfs.13068}, url = {1789689}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {children; domestic violence; protective factor; risk factor; risk management; vulnerability factor}, abstract = {Effective risk management strategies for victims of domestic violence require an adequate risk assessment. While risk assessments for domestic violence typically focus on the adult victim, the risk of children who are exposed to such violence is often overlooked. This study aims to explore what risk, vulnerability and protective factors can be identified through forensic interviews with children exposed to domestic violence. A qualitative latent content analysis was conducted on documented forensic interviews with 41 children. The results show that children reported factors that should be taken into consideration when managing the risk of violence for their mother. In addition, the children's responses suggest the need for a separate risk management plan to address their needs and to protect them from re-victimization. Direct communication with children is crucial to identify factors that are unique to them. These results emphasize the significance of including their perspective in risk assessments for domestic violence to influence the risk management that includes both mothers and their children.}, issn = {1356-7500}, file = {https://oru.diva-portal.org/smash/get/diva2:1789689/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lanotantoine_2025, title = {Enhancing individual glomerular filtration rate assessment : can we trust the equation? Development and validation of machine learning models to assess the trustworthiness of estimated GFR compared to measured GFR}, author = {Lanot, Antoine and Akesson, Anna and Nakano, Felipe Kenji and Vens, Celine and Björk, Jonas and Nyman, Ulf and Grubb, Anders and Sundin, Per-Ola and Eriksen, Björn O. and Melsom, Toralf and Rule, Andrew D. and Berg, Ulla and Littmann, Karin and Åsling-Monemi, Kajsa and Hansson, Magnus and Larsson, Anders and Courbebaisse, Marie and Dubourg, Laurence and Couzi, Lionel and Gaillard, Francois and Garrouste, Cyril and Jacquemont, Lola and Kamar, Nassim and Legendre, Christophe and Rostaing, Lionel and Ebert, Natalie and Schaeffner, Elke and Bökenkamp, Arend and Mariat, Christophe and Pottel, Hans and Delanaye, Pierre}, year = {2025}, journal = {BMC Nephrology}, volume = {26}, number = {1}, doi = {10.1186/s12882-025-03972-0}, url = {1933287}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {chronic kidney disease; creatinine; glomerular filtration rate; machine learning; random forest}, abstract = {BACKGROUND: Creatinine-based estimated glomerular filtration rate (eGFR) equations are widely used in clinical practice but exhibit inherent limitations. On the other side, measuring GFR is time consuming and not available in routine clinical practice. We developed and validated machine learning models to assess the trustworthiness (i.e. the ability of equations to estimate measured GFR (mGFR) within 10%, 20% or 30%) of the European Kidney Function Consortium (EKFC) equation at the individual level.METHODS: This observational study used data from European and US cohorts, comprising 22,343 participants of all ages with available mGFR results. Four machine learning and two traditional logistic regression models were trained on a cohort of 9,202 participants to predict the likelihood of the EKFC creatinine-derived eGFR falling within 30% (p30), 20% (p20) or 10% (p10) of the mGFR value. The algorithms were internally and then externally validated on cohorts of respectively 3,034 and 10,107 participants. The predictors included in the models were creatinine, age, sex, height, weight, and EKFC.RESULTS: The random forest model was the most robust model. In the external validation cohort, the model achieved an area under the curve of 0.675 (95%CI 0.660;0.690) and an accuracy of 0.716 (95%CI 0.707;0.725) for the P30 criterion. Sensitivity was 0.756 (95%CI 0.747;0.765) and specificity was 0.485 (95%CI 0.460; 0.511) at the 80% probability level that EKFC falls within 30% of mGFR. At the population level, the PPV of this machine learning model was 89.5%, higher than the EKFC P30 of 85.2%. A free web-application was developed to allow the physician to assess the trustworthiness of EKFC at the individual level.CONCLUSIONS: A strategy using machine learning model marginally improves the trustworthiness of GFR estimation at the population level. An additional value of this approach lies in its ability to provide assessments at the individual level.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bergemalmdaniel_2025, title = {Environmental and Inflammatory Factors Drive Perinuclear-Antineutrophil Cytoplasmic Antibodies (pANCA) in Ulcerative Colitis : A European Twin Study}, author = {Bergemalm, Daniel and Amcoff, Karin and Pierik, Marie J. and Colombel, Jean-Frederic and Vermeire, Severine and Bodin, Lennart and Carlson, Marie and Halfvarson, Jonas}, year = {2025}, journal = {United European Gastroenterology journal}, volume = {13}, number = {10}, pages = {1964--1973}, doi = {10.1002/ueg2.70101}, url = {1991345}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {environmental factors; genetic factors; perinuclear‐antineutrophil cytoplasmic antibodies (panca); smoking; subclinical inflammation; twin study; ulcerative colitis}, abstract = {BACKGROUND: Perinuclear-antineutrophil cytoplasmic antibodies (pANCA) have been identified in familial ulcerative colitis (UC), but the mechanism underlying their expression remains elusive. We assessed the role of genetic predisposition, environmental factors and systemic subclinical inflammation in the development of pANCA in a twin cohort with UC.METHODS: A total of 48 twin pairs (Leuven, Belgium n = 4, Maastricht, The Netherlands n = 6 and Örebro, Sweden n = 38) with UC were included. Among these, 18 were monozygotic (3 concordant and 15 discordant for UC) and 30 were dizygotic (1 concordant and 29 discordant for UC). P-ANCA was detected through standardised ELISA, an indirect immunofluorescence assay and DNase treatment. In addition to high sensitivity C-reactive protein (hs-CRP), 92 inflammatory protein markers were measured in serum by proximity extension assay.RESULT: Perinuclear-ANCA was present in 15/52 (29%) of UC twins vs. 4/44 (9%) healthy twin siblings (p = 0.02). No agreement in the presence of pANCA or their levels was observed between twin siblings in monozygotic pairs discordant for UC [intraclass correlation coefficient (ICC) = 0.09] or dizygotic pairs (ICC = -0.20). Female sex was associated with an increased likelihood of pANCA (odds ratio, OR 5.25; 95% confidence interval, CI 1.36-20.30) and higher ANCA levels (ratio of geometric means 1.86; 95% CI 1.18-2.93). Active smoking was associated with lower concentrations of ANCA (ratio of geometric means 0.31; 95% CI 0.14-0.68) and potentially reduced the likelihood of pANCA (OR 0.20; 95% CI 0.03-1.34) in twins with UC but not in their healthy siblings. In healthy twin siblings, significant correlations between ANCA levels and hs-CRP, CDCP1, IL17 A, CXCL9 and IL5 (correlation coefficients 0.36-0.41, p-values < 0.05) were observed.CONCLUSION: Female sex and tobacco smoking outweighed genetics regarding the generation and levels of pANCA and ANCA antibodies. The correlations between ANCA levels and inflammatory markers in healthy twin siblings suggest that pANCA may result from subclinical inflammation.}, issn = {2050-6406} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bergemalmdaniel_2025_1, title = {Environmental factors, genetic predisposition and subclinical inflammation in the development of perinuclear-antineutrophil cytoplasmic antibody (P-ANCA)-positive ulcerative colitis : A European twin study}, author = {Bergemalm, Daniel and Amcoff, K. and Pierik, M. J. and Colombel, J. F. and Vermeire, S. and Bodin, L. and Halfvarson, Jonas}, year = {2025}, journal = {Journal of Crohn's & Colitis}, volume = {19}, number = {Suppl. 1}, pages = {i787--i787}, doi = {10.1093/ecco-jcc/jjae190.0500}, url = {1940366}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background: Perinuclear-antineutrophil cytoplasmic antibodies (P-ANCAs) have been identified in familial ulcerative colitis (UC), but the precise mechanism underlying their expression remains elusive. We assessed the role of genetic predisposition, environmental factors and systemic subclinical inflammation in the development of P-ANCA in a twin cohort with UC.Methods: A total of 48 twin pairs (Leuven, Belgium n=4, Maastricht, The Netherlands n=6 and Örebro, Sweden n=38) with UC were included. Among these, 18 were monozygotic (3 concordant and 15 discordant for UC) and 30 were dizygotic (1 concordant and 29 discordant for UC). P-ANCA was detected through standardised ELISA, an indirect immunofluorescence assay and DNase treatment. In addition to high sensitivity C-reactive protein (hs-CRP), 92 inflammatory protein markers were measured in serum by proximity extension assay (Olink proteomics).Results: P-ANCA was present in 16/52 (31%) of UC twins vs. 4/44 (9%) healthy twin siblings (p=0.01). No agreement in the presence of P-ANCA or their levels was observed between twin siblings in monozygotic pairs discordant for UC [intraclass correlation coefficient (ICC)=0.09] or dizygotic pairs (ICC=-0.20). Female sex was associated with an increased likelihood of P-ANCA (odds ratio, OR 5.49; 95% confidence interval, CI 1.47-20.57) and higher ANCA levels (ratio of geometric means 1.80; 95% CI 1.12-2.88). Active smoking was associated with lower concentrations of ANCA (ratio of geometric means 0.33; 95% CI 0.15-0.75) and potentially reduced the likelihood of P-ANCA (OR 0.23; 95% CI 0.02-2.21) in twins with UC but not in their healthy siblings. In twin siblings without UC, significant correlations between ANCA levels and hs-CRP, CDCP1, IL17A, CXCL9 and IL5 (correlation coefficients 0.36-0.41, p-values <0.05) were observed.Conclusion: Female sex and tobacco smoking outweighed genetics regarding the generation and levels of P-ANCA and ANCA antibodies. The correlations between ANCA levels and inflammatory markers in healthy twin siblings suggest that P-ANCA may result from subclinical inflammation in these healthy siblings.}, issn = {1873-9946} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_boutinlola_2025, title = {EphA2 and phosphoantigen-mediated selective killing of medulloblastoma by γδT cells preserves neuronal and stem cell integrity}, author = {Boutin, Lola and Liu, Mingzhi and Déchanet Merville, Julie and Bedoya Reina, Oscar and Wilhelm, Margareta T.}, year = {2025}, journal = {Oncoimmunology}, volume = {14}, number = {1}, doi = {10.1080/2162402X.2025.2485535}, url = {1950592}, language = {eng}, publisher = {Taylor & Francis}, keywords = {gamma delta t cells; immunotherapy; medulloblastoma}, abstract = {Medulloblastoma (MB) is a pediatric brain tumor that develops in the cerebellum, representing one of the most common malignant brain cancers in children. Standard treatments include surgery, chemotherapy, and radiation, but despite a 5-y survival rate of approximately 70%, these therapies often lead to significant neurological damage in the developing brain. This underscores the urgent need for less toxic, more effective therapeutic alternatives. Recent advancements in cancer immunotherapy, including immune checkpoint inhibitors and CAR-T cell therapy, have revolutionized cancer treatment. One promising avenue is the use of Gamma Delta (γδ)T cells, a unique T cell population with potential advantages, such as non-alloreactivity, potent tumor cell lysis, and broad antigen recognition. However, their capacity to recognize and target MB cells remains underexplored. To investigate the therapeutic potential of γδT cells against MB, we analyzed the proportion and status of MB-infiltrated γδT cells within patient datasets. We next investigated the expression of γδT cell ligands on MB cells and identified the EphA2 receptor and the phosphoantigen/Butyrophilin complex as key ligands, activating Vγ9 Vδ1 and Vγ9 Vδ2 T cells, respectively, leading to significant MB cell lysis in both monolayer and spheroid models. Importantly, preliminary safety data showed that γδT cells did not target differentiated neurons or neuroepithelial stem cells derived from induced pluripotent stem cells, underscoring the selectivity and safety of this approach. In conclusion, γδT cells trigger an efficient and specific killing of MB and would offer a promising novel therapeutic strategy.}, issn = {2162-4011} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_caripotieugenio_2025, title = {E-PhishGEN : Unlocking Novel Research in Phishing Email Detection}, author = {Caripoti, Eugenio and Pajola, Luca and Banzer, Stefan and Pizzi, Simeone and Conti, Mauro and Apruzzese, Giovanni}, year = {2025}, pages = {64--76}, doi = {10.1145/3733799.3762967}, url = {2041921}, language = {eng}, publisher = {Association for Computing Machinery (ACM)}, keywords = {benchmark; dataset; large language models; email; spam; detection}, abstract = {Every day, our inboxes are flooded with unsolicited emails, ranging between annoying spam to more subtle phishing scams. Unfortunately, despite abundant prior efforts proposing solutions achieving near-perfect accuracy, the reality is that countering malicious emails still remains an unsolved dilemma. This "open problem" paper carries out a critical assessment of scientific works in the context of phishing email detection. First, we focus on the benchmark datasets that have been used to assess the methods proposed in research. We find that most prior work relied on datasets containing emails that-we argue-are not representative of current trends, and mostly encompass the English language. Based on this finding, we then re-implement and re-assess a variety of detection methods reliant on machine learning (ML), including large-language models (LLM), and release all of our codebase-an (unfortunately) uncommon practice in related research. We show that most such methods achieve near-perfect performance when trained and tested on the same dataset-a result which intrinsically hinders development (how can future research outperform methods that are already near perfect?). To foster the creation of "more challenging benchmarks" that reflect current phishing trends, we propose E-PhishGEN, an LLM-based (and privacy-savvy) framework to generate novel phishing-email datasets. We use our E-PhishGEN to create E-PhishLLM, a novel phishing-email detection dataset containing 16616 emails in three languages. We use E-PhishLLM to test the detectors we considered, showing a much lower performance than that achieved on existing benchmarks-indicating a larger room for improvement. We also validate the quality of E-PhishLLM with a user study (n=30). To sum up, we show that phishing email detection is still an open problem-and provide the means to tackle such a problem by future research.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vroomenmindy_2025, title = {Epicardial and hybrid surgical ablation of atrial fibrillation : 1-year follow-up outcomes of the EORP EHAFA registry}, author = {Vroomen, Mindy and La Meir, Mark and Mokracek, Ales and Doll, Kai N. and Folliguet, Thierry A. and Blomström-Lundqvist, Carina and Mont, Lluís and Peters, Nicholas S. and Pison, Laurent}, year = {2025}, journal = {Europace}, volume = {27}, number = {9}, doi = {10.1093/europace/euaf196}, url = {1999627}, language = {eng}, publisher = {Oxford University Press}, keywords = {atrial fibrillation; epicardial ablation; hybrid ablation; registry; surgical ablation}, abstract = {AIMS: Stand-alone minimal invasive epicardial and hybrid atrial fibrillation ablation (EHAFA) has evolved to a recognized treatment option in challenging patients. The EHAFA registry was initiated to describe the applied diagnostic and therapeutic approaches used in routine practice for these procedures, as well as the outcomes in terms of rhythm, symptoms, and complications.METHODS AND RESULTS: Between January 2016 and March 2018, patients who underwent an EHAFA procedure for all types of atrial fibrillation (AF) were consecutively enrolled in the international, prospective, observational EHAFA registry. Follow-up occurred after 1 year. A total of 468 patients were enrolled from 17 centres in 10 countries. Stand-alone ablation (n = 464) was performed epicardially in 47% (n = 220) or as epi-/endocardial hybrid in 53% (n = 244). The predominate type of AF was non-paroxysmal in 74% (n = 342), and 36% (n = 166) of patients had failed previous catheter ablation. The main lesion sets applied consisted of pulmonary vein isolation (99%, n = 460) and isolation of the left atrial (LA) posterior wall (82%, n = 383). In 82% (n = 382), the LA appendage was managed. The overall in-hospital major complication rate was 8.2% (n = 38/464). Freedom from atrial arrhythmias > 30 s with and without antiarrhythmic drug usage was 79% and 64% (n = 279/353, n = 223/351, respectively). The EHRA score at follow-up was clearly reduced compared to preoperatively (EHRA I: 72%, n = 233/325, vs. 3%, n = 14/464).CONCLUSION: This international registry revealed good rhythm control efficacy for epicardial and hybrid AF ablation in patients with advanced AF, leading to improvement in AF-related symptoms. However, a certain associated complication rate needs to be considered.}, issn = {1099-5129} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sweetingarianne_2025, title = {Epidemiology and Management of Gestational Diabetes COMMENT}, author = {Sweeting, Arianne and Hannah, Wesley and Backman, Helena and Catalano, Patrick and Feghali, Maisa and Herman, Willliam H. and Hivert, Marie-France and Immanuel, Jincy and Meek, Claire and Oppermann, Maria Lucia and Nolan, Christopher J. and Ram, Uma and Schmidt, Maria Ines and Simmons, David and Chivese, Tawanda and Benhalima, Katrien}, year = {2025}, journal = {Obstetrical and Gynecological Survey}, volume = {80}, number = {1}, pages = {12--15}, doi = {10.1097/01.ogx.0001097920.09573.35}, url = {1935748}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, issn = {0029-7828} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_cewepaulina_2025, title = {Epidemiology and Screening of Traumatic Vertebral Artery Injuries at a Large Scandinavian Level 1 Trauma Center}, author = {Cewe, Paulina and Staartjes, Victor E. and El-Hajj, Victor Gabriel and Al-Rikabi, Ihab Ahmad and Musmar, Basel and Roy, Joana M. and Troung, Dennis and Beckman, Mats and Ohlsson, Marcus and Jabbour, Pascal and Elmi-Terander, Adrian and Edström, Erik}, year = {2025}, journal = {Neurospine}, volume = {22}, number = {4}, pages = {905--915}, doi = {10.14245/ns.2551070.535}, url = {2027132}, language = {eng}, publisher = {Korean Spinal Neurosurgery Society}, keywords = {angiography; blunt cervical vascular injury; cervical spine; computed tomography; trauma; vertebral artery}, abstract = {OBJECTIVE: Traumatic vertebral artery injuries (tVAIs) are uncommon but potentially devastating if missed. While computed tomography angiography (CTA) is routinely used for diagnosis, data on the number needed to image (NNI) remain limited. We hence analyzed tVAI epidemiology and imaging practices at a major Scandinavian level 1 trauma center.METHODS: A retrospective study (2013-2020) was performed based on a single-center trauma registry. Patients were grouped based on CTA imaging protocol used; selective screening (2013-2017) and universal screening (2018-2020). Imaging protocols, treatment strategies, and outcomes were analyzed.RESULTS: Among 2,843 patients admitted with level 1 trauma and receiving CTA imaging, 62 had a tVAI (2.2%) yielding a NNI of 46 patients to diagnose 1 tVAI. Twenty-five of these patients (40.3%) were found to have a posterior circulation stroke, resulting in an incidence of 0.9%, and a NNI of 114 to diagnose 1 stroke on CTA. NNIs for both tVAI and stroke detection increased with adoption of universal screening (tVAI: 35→65; stroke: 90→149). However, the detection rate of tVAI during the universal screening period was not significantly higher than during the selective screening period (p=0.261).CONCLUSION: In our level 1 trauma cohort, the incidence of tVAI was 2.2% and stroke rate 0.9%. The NNI rose with universal screening, yet detection rates did not improve. These findings suggest that selective screening based on risk factors may be more efficient than a universal approach. Further research is needed to balance diagnostic accuracy with resource use in trauma care.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_saeidzadehzara_2025, title = {Epistemic Injustice against Trans* Citizens in Iran}, author = {Saeidzadeh, Zara}, year = {2025}, journal = {Anthropology of the Middle East}, volume = {20}, number = {1}, pages = {25--41}, doi = {10.3167/ame.2025.200102}, url = {2028287}, language = {eng}, publisher = {Berghahn Journals}, keywords = {epistemic misrecognition; iranian society; medical jurisprudence; trans*citizenship}, abstract = {In this article, I explore how trans* citizens are recognized in Iranian society by analysing the production of knowledge within jurisprudential, legal, and medical systems. I use the concept of epistemic misrecognition as my theoretical tool drawing on Miranda Fricker’s (2007) notion of epistemic injustice in consolidation with Nancy Fraser’s (2001) work on status misrecognition. Addressing interviews with trans* people, surgeons, activists, and a jurist in Iran, I discuss how the limited knowledge of Islamic jurisprudence, coupled with the medical system’s narrow understanding of gender, establish an authoritative sources of knowledge that perpetuate various forms of harm against trans* people at individual, institutional and structural levels in society. Nevertheless, trans* people understand and embody gender independently of this knowledge, struggling for status recognition as equal citizens.}, issn = {1746-0719} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_leontowitschmiranda_2025, title = {EQualCare : Alone but connected? Digital (in)equalities in care work and generational relationships among older people living alone – White Paper}, author = {Leontowitsch, Miranda and Werny, Rafaela and Henning, Smilla and Oswald, Frank and Niemistö, Charlotta and Sjögren, Hanna and Hearn, Jeff and Putnina, Aivita and Mileiko, Ilze and Malm, Camilla and Andersson, Marcus and Krekula, Clary}, year = {2025}, doi = {10.21248/gups.70657}, url = {1958430}, language = {eng}, publisher = {Frankfurter Forum für interdisziplinäre Alternsforschung, Goethe-Universität}, keywords = {age; ageing; care; digitalisation}, abstract = {The digital age requires people of all ages to communicate and organise their lives through digital technologies. The project EQualCare (“Alone but connected? Digital (in)equalities in care work and generational relationships among older people living alone”) investigated how the growing population of older people living alone is man-aging this transition, how it shapes their (non-)digital social networks and what changes on local, regional, national and international levels need to be brought about to ensure (digital) equality. This white paper gives insight into the multi-method work that was done, summarises key findings, and provides recommendations for policy and practice.EQualCare was a cross-cultural comparison and collaboration across Finland, Ger-many, Latvia and Sweden, with Finland and Sweden as two countries advanced in the digitalisation of civic and private life and thus providing a helpful contrast to Germany and Latvia that are at different levels of digitalisation. Their joint work comprised of four parts: • To begin with all four national researcher teams conducted respective critical document analyses of social policy documents and legislation, examining how ageing, living alone, digitalisation, and care-responsibilities are portrayed in the national policy documents. • Following, an analyses of existing national and EU data sets on ageing took place to draw comparative information on living conditions, income, health, use of dig-ital devices, and care work across the four countries. • The central part of EQualCare entailed a participatory action research (PAR) project that was conducted across the four countries and involved older people as co-researchers in nine local project teams. • The model of EQualCare was a participatory policy making one, whereby the work of one of the PAR projects was connected with the others, with the findings from the policy analyses and statistical analyses providing the backdrop and scaf-folding to develop the recommendations.The project team was strongly multidisciplinary; bring together experienced re-searchers in anthropology, business organisation and management studies, cultural studies, education, gender studies, psychology, social psychology, social work and sociology.}, file = {https://oru.diva-portal.org/smash/get/diva2:1958430/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_mouazzenannakarin_2025, title = {Erfarenheter av interprofessionell teamsamverkan i företagshälsovården}, author = {Mouazzen, Anna-Karin and Jaensson, Maria and Blomberg, Karin}, year = {2025}, url = {1958760}, language = {swe}, abstract = {Bakgrund:Företagshälsovården (FHV) är en expertresurs i arbetsmiljöfrågor och kan ge stöd och bidra med kunskap till sina kunder i deras systematiska arbetsmiljöarbete. Samverkan mellan de olika professionerna i FHV kan vara avgörande för kvaliteten på den service som ges till kunden. Syfte:Syftet med studien var att utforska erfarenheter av interprofessionell teamsamverkan bland medarbetare i FHV i Sverige.Metod:Fem fokusgruppsdiksussioner (FGD) genomfördes under februari och mars 2024 på fyra olika hälsor i Svealand. Antalet deltagare varierade mellan tre och tio och representerade nio olika professioner inom FHV. En semistrukturerad intervjuguide användes vid FGD som spelades in och transkirberades. Reflexiv tematisk analys enligt Braun och Clarke genomfördes. Resultat:Analysen ledde fram till det övergripande teamt FHV-teamet är dynamiskt och flexibelt, och tre huvudteman samt fem underteman. Möjligheten att arbeta tillsammans bidrar till kunskapsutveckling. Förutsättningar för teamsamverkan påverkas av tid, avstånd och stöd från den egna chefen och organisationen. Olika syn på evidensbaserad praktik och brist på utbildning i FHV kan bli barriärer som motverkar teamsamverkan. Den egna arbetsmiljön påverkas positivt av samarbetet med att utveckla hälsosamma arbetsplatser hos kunderna.Konklussion:Att känna varandra och ha samsyn ökar möjligheterna för teamsamverkan. Avstånd och brist på tid kan vara hinder för teamsamverkan. Genom en välfungerande teamsaverkan kan FHV möta kundernas behov av stö i arbetet med att utveckla hälsosamma arbetsplatser. Teamsamverkan är hälsofrämjade för medarbetarna i FHV.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wongeyt_2025, title = {ESMO guidance on the use of Large Language Models in Clinical Practice (ELCAP)}, author = {Wong, E Y. T. and Verlingue, L. and Aldea, M. and Franzoi, M. A. and Umeton, R. and Halabi, S. and Harbeck, N. and Indini, A. and Prelaj, A. and Romano, E. and Smyth, E. and Tan, I. B. and Valachis, Antonis and Vibert, J. and Wiest, I. C. and Yang, Y. H. and Gilbert, S. and Kapetanakis, G. and Pentheroudakis, G. and Koopman, M. and Kather, J. N.}, year = {2025}, journal = {Annals of Oncology}, volume = {36}, number = {12}, pages = {1447--1457}, doi = {10.1016/j.annonc.2025.09.001}, url = {2007407}, language = {eng}, publisher = {Elsevier}, keywords = {ai; clinical decision making; large language model}, abstract = {BACKGROUND: Large language models (LLMs) are rapidly being integrated into health care, with substantial implications for oncology practice. The European Society for Medical Oncology (ESMO) developed the ESMO guidance on the use of Large Language Models in Clinical Practice (ELCAP) to provide a structured framework and basic guidance for their safe and effective application in oncology.PATIENTS AND METHODS: Between November 2024 and February 2025, a multidisciplinary group of 20 experts convened under the ESMO Real World Data and Digital Health Task Force. Using literature review and a Delphi consensus process, the panel defined three categories of LLM use in oncology: type 1 (patient-facing applications), type 2 [health care professional (HCP)-facing applications], and type 3 (background institutional systems). Consensus statements were developed for each type to provide basic practical guidance.RESULTS: ELCAP highlights opportunities such as improved patient education and symptom management, streamlined clinical workflows, and enhanced data processing. At the same time, it addresses challenges including data privacy, algorithmic bias, regulatory compliance, and the risk of unsupervised use. The framework emphasises human oversight, protection of patient privacy, and alignment with clinical and ethical standards. Patient-facing tools should complement, not replace, professional advice and should be embedded in supervised care pathways. HCP-facing and background systems may improve efficiency and decision support but require systematic validation, transparency, and continuous monitoring.CONCLUSIONS: ELCAP provides a three-tier framework and basic practical guidance for LLM use in oncology. ESMO supports efforts to use this framework to improve patient care, but warns against unsupervised or unvalidated use.}, issn = {0923-7534} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_weimannarved_2025, title = {ESPEN guideline on clinical nutrition in surgery - Update 2025}, author = {Weimann, Arved and Bezmarevic, Mihailo and Braga, Marco and Correia, M. Isabel T. D. and Funk-Debleds, Pamela and Gianotti, Luca and Gillis, Chelsia and Hübner, Martin and Inciong, Jesus Fernando B. and Jahit, Mohammad Shukri and Klek, Stanislaw and Kori, Takayuki and Laviano, Alessandro and Ljungqvist, Olle and Lobo, Dileep N. and Segurola, Carmelo Loinaz and Montroni, Isacco and Reddy, B. Ravinder and Saur, Nicole M. and Schweinlin, Anna and Shi, Han-Ping and Takeuchi, Hiroya and Waitzberg, Dan L. and Wallengren, Ola and Wischmeyer, Paul E. and Ysebaert, Dirk and Bischoff, Stephan C.}, year = {2025}, journal = {Clinical Nutrition}, volume = {53}, pages = {222--261}, doi = {10.1016/j.clnu.2025.08.029}, url = {1998766}, language = {eng}, publisher = {Elsevier}, keywords = {enhanced recovery after surgery; enteral nutrition; parenteral nutrition; perioperative nutrition; prehabilitation}, abstract = {Early oral feeding is the preferred mode of nutrition for surgical patients. Avoidance of any nutritional therapy bears the risk of underfeeding during the postoperative course after major surgery. Considering that malnutrition and underfeeding are risk factors for postoperative complications, nutritional therapy is mandatory for any surgical patient at nutritional risk, especially for those undergoing upper gastrointestinal surgery. The focus of this guideline is to cover nutritional aspects of the Enhanced Recovery After Surgery (ERAS) concept and the special nutritional needs of patients undergoing major surgery, e.g. for cancer, and of those developing severe complications despite best perioperative care. From a metabolic and nutritional point of view, the key aspects of perioperative care include: a) Integration of nutrition into the overall management of the patient, b) avoidance of long periods of preoperative fasting c) re-establishment of oral feeding as early as possible after surgery d) start of nutritional therapy early, as soon as a nutritional risk becomes apparent e) metabolic control e.g. of blood glucose, f) reduction of factors which exacerbate stress-related catabolism or impair gastrointestinal function, g) minimized time on paralytic agents in the postoperative period, and h) early mobilization to facilitate protein synthesis and muscle function. The guideline presents 44 recommendations for clinical practice in patients undergoing elective and non-elective surgery, including new recommendations for frailty assessment, sarcopenia diagnosis, and prehabilitation. As in the former ESPEN practical guideline, the recommendations were additonally presented in decision-making flowcharts.}, issn = {0261-5614} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rutegrdmartin_2025_1, title = {Estimation of the postoperative fatality window in colorectal cancer surgery}, author = {Rutegård, Martin and Matthiessen, Peter and Rutegård, Jörgen and Haapamäki, Markku M. and Svensson, Johan}, year = {2025}, journal = {BJS Open}, volume = {9}, number = {1}, doi = {10.1093/bjsopen/zrae153}, url = {1931323}, language = {eng}, publisher = {Oxford University Press}, keywords = {colorectal cancer; surgical procedures; operative; colon; mortality; specialty; rectal carcinoma; american society of anesthesiologists}, abstract = {BACKGROUND: Postoperative death measured 30 days after surgery is a conventional quality metric, whereas intervals up to 90 days are increasingly used, although data-driven time windows have scarcely been investigated.METHODS: The Swedish Colorectal Cancer Registry was used to identify all patients subjected resection for colorectal cancer between 2007 and 2020. All patients were followed up until 180 days after surgery. A join-point statistical hazard model was used to model a declining hazard to a transition point, followed by a stable death rate. This method was subsequently applied to describe postoperative deaths for the entire cohort and subgroups according to tumour location (colon and rectum).RESULTS: Some 56 096 patients electively operated on for colorectal cancer during the study interval were included, with a 30-day and 90-day fatality of 805 (1.43%) and 1458 (2.60%) patients respectively. The derived postoperative fatality window, after which the death rate transitioned to a stable rate, was 23.8 (95% c.i. 21.5 to 28.2) days after surgery. There was no significant difference in the time window between rectal cancer (22.9 days; 95% c.i. 15.1 to 28.4) and colon cancer (27.3 days; 95% c.i. 21.4 to 31.8) patients (P = 0.455). However, postoperative fatality time windows were extended in patients aged at least 80 years and with American Society of Anesthesiologists' grade III or IV.CONCLUSION: The traditional postoperative time window of 30 days was confirmed to be an appropriate metric in elective colorectal cancer surgery when evaluated with a hazards-based statistical framework. Importantly, this time window is influenced by older age and advanced co-morbidity, which could prompt increased vigilance for these patient groups.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_ilvesmaiki_2025, title = {Estimation with probability edited survey data under nonresponse}, author = {Ilves, Maiki}, year = {2025}, url = {1949604}, language = {eng}, publisher = {Örebro University School of Business}, keywords = {nonsampling errors; probabilistic editing; selective editing; calibration estimator; measurement bias estimation}, abstract = {Probabilistic editing has been introduced to enable valid inference using established survey sampling theory in situations when some of the collected data points may have measurement errors and are therefore submitted to an editing process. To reduce the editing effort anavoid over-editing, in current practice selective editing is most often used, which is a form of editing that limits the edit checks to those potential errors that, if indeed in error, are likely to have the biggest impact on estimates to be produced. However, selective editing is not grounded in probability theory associated with survey sampling, and cannot provide expressions for point and variance estimates that account for the uncertainties introduced by selective editing.In the spirit of the total survey error paradigm, this paper extends the previous work on probabilistic editing by proposing an estimation procedure that provides valid inference when two kinds of nonsampling error are simultaneously present, in addition to the sampling error: the measurement error, requiring an editing step, and the practically unavoidable nonresponse error which also needs to be taken into account when producing unbiased estimates.In a three-phase selection setup, bias due to measurement error is estimated through probabilistic editing while weight adjustment employing auxiliary information is used to deal with nonresponse. An estimator based on calibration for nonresponse and corrected for bias due to measurement error is introduced. Its theoretical variance and an estimator of the variance are derived. A simulation study illustrates the three-phase selection setup and the practical performance of the derived point and variance estimators.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sandlundmikael_2025, title = {Ethical Considerations Regarding the Vaccination of Children-The Power Dynamics Between Doctors and Parents}, author = {Sandlund, Mikael and Engström, Ingemar and Castor, Anders}, year = {2025}, journal = {Acta Paediatrica}, doi = {10.1111/apa.70367}, url = {2012561}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, abstract = {While childhood vaccination programmes provide outstanding contributions to improving health, they can also pose challenges through the interactions between parents and healthcare. This paper focuses on the ethical dimensions of interactions between healthcare professionals and parents. Since the knowledge that professionals possess creates an asymmetrical relationship with parents, it can be helpful to analyse the situation from a power perspective. An example of ethical problem-solving using a simple model for discussing ethically difficult situations is demonstrated.}, issn = {0803-5253} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_yuenlili_2025, title = {Ethnic Differences in Characteristics of Women Diagnosed with Early Gestational Diabetes : Findings from the TOBOGM Study}, author = {Yuen, Lili and Wong, Vincent and Immanuel, Jincy and Hague, William M. and Cheung, N. Wah and Teede, Helena and Hibbert, Emily and Nolan, Christopher J. and Peek, Michael and Flack, Jeff R. and McLean, Mark and Sweeting, Arianne and Kautzky-Willer, Alexandra and Harreiter, Jürgen and Gianatti, Emily and Mohan, Viswanathan and Backman, Helena and Simmons, David}, year = {2025}, journal = {Journal of Clinical Endocrinology and Metabolism}, volume = {110}, number = {8}, pages = {e2471--e2484}, doi = {10.1210/clinem/dgae838}, url = {1921451}, language = {eng}, publisher = {Oxford University Press}, keywords = {early diagnosis; ethnic differences; ethnicity; gestational diabetes; pregnancy-associated diabetes; screening}, abstract = {OBJECTIVE: To compare the prevalence and clinical characteristics of early gestational diabetes (eGDM) and associated birth outcomes amongst women of different ethnic groups.RESEARCH DESIGN AND METHODS: This is a secondary analysis of an international, multicentre randomized controlled trial of treating eGDM among pregnant women with GDM risk factors enrolled <20 weeks' gestation. The diagnosis of GDM was made using WHO-2013 criteria. While Europids required at least one risk factor for recruitment, for others, ethnicity itself was a risk factor.RESULTS: Among women of Europid (n=1,567), South Asian (SA: n=971), East and South-East Asian (ESEA: n=498), Middle Eastern (ME: n=242) and Māori and Pasifika (MP: n=174) ethnicities; MP (26.4%) had the highest eGDM crude prevalence compared with Europid (20.3%), SA (24.7%), ESEA (22.3%) and ME (21.1%) (p<0.001). Compared with Europid, the highest eGDM adjusted odds ratio (aOR) was seen in SA (2.43 [95%CI 1.9-3.11]) and ESEA (aOR 2.28 [95%CI 1.68-3.08]); in late GDM, SA had the highest prevalence (20.4%: aOR 2.16 [95%CI 1.61-2.9]). Glucose patterns varied between ethnic groups and ESEA were predominantly diagnosed with eGDM through post-glucose load values, while all other ethnic groups were mainly diagnosed on fasting glucose values. There were no differences in the eGDM composite primary outcome or neonatal and pregnancy-related hypertension outcomes between the ethnic groups.CONCLUSIONS: In women with risk factors, eGDM was most prevalent in SA and ESEA women, particularly identified by the post-glucose load samples. These findings suggest an early OGTT should particularly be performed in women from these ethnic groups.}, issn = {0021-972X} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_bayramzdemirsevgi_2025, title = {Ethnic/racial bullying and victimization during childhood and adolescence}, author = {Bayram Özdemir, Sevgi and Gönültaş, Seçil}, year = {2025}, url = {1944222}, language = {eng}, publisher = {Cambridge University Press} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_berglundkarin_2025, title = {Ethnographic approaches to entrepreneurship and small-business research : what lessons can we learn?}, author = {Berglund, Karin and Wigren, C.}, year = {2025}, pages = {250--272}, doi = {10.4337/9781035345946.00016}, url = {2029845}, language = {eng}, publisher = {Edward Elgar Publishing Ltd.}, keywords = {context; doing ethnography; entrepreneurship; ethnography; research process; role of the researcher}, abstract = {This chapter shows how entrepreneurship and small and medium-sized enterprises (SMEs) can be researched through the ethnographic method, focusing on understanding the social context of a certain phenomenon or person. Specifically, four ethnographic studies are introduced, which are discussed as themes: context, the role of the researcher, the research process, and lessons learned.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_1, title = {EU DIALOUGE AND VAT PRECEDENCE IN SWEDEN : OVERRULING AND DISTINGUSING IN THE SUPREME ADMINISTRATIVE COURT}, author = {Kristoffersson, Eleonor and Kristoffersson, Magnus and Aiderfors, Kevin}, year = {2025}, pages = {157--176}, url = {2031864}, language = {eng}, publisher = {Wolters Kluwer}, keywords = {vat; ai} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_2, title = {EU skjuter över ansvaret för betalning av importmoms från konsumenterna till leverantörerna – analys}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031836}, language = {swe}, publisher = {JP Infonet}, keywords = {mervärdesskatt; moms}, abstract = {Distanshandel med varor från länder utanför EU har ökat lavinartat sedan Covid-19-pandemin. Den 18 juli 2025 antog Europeiska unionens råd ett nytt direktiv om förenklad och förbättrad mervärdesskatteuppbörd vid import. Genom de nya reglerna skjuts ansvaret för betalning av mervärdesskatt över från konsumenterna till leverantörerna, och möjligheten att använda den så kallade Import-One-Stop-Shop (IOSS) utvidgas. Reglerna börjar gälla den 1 juli 2028. JP Infonets expert professor Eleonor Kristoffersson berättar om det nya direktivet. } } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_3, title = {EU-dom om momsavdrag för koncerninterna tjänster}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031714}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 12 december kom EU-domstolens dom i C-527/23 Weatherford Atlas Gip. Domen avser avdrag för ingående moms för koncerninterna administrativa tjänster vid kostnadsdelning. Professor Eleonor Kristoffersson analyserar domen.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_4, title = {EU-domstolen fastslår att formella fel i tullförfarandet inte hindrar momsbefrielse om inte försök till bedrägeri föreligger – analys}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031838}, language = {swe}, publisher = {JP Infonet}, keywords = {mervärdesskatt; moms}, abstract = {Den 12 juni 2025 meddelade EU-domstolen dom i mål C-125/24 Palmstråle. Målet avser två tävlingshästar som hade tävlat i Norge och där Tullverket påförde importmoms när hästarna återvände till Sverige. Rättsligt avser domen 10 kap. 54 § mervärdesskattelagen och 2 kap. 5 § lagen om frihet från skatt vid import m.m. JP Infonets expert professor Eleonor Kristoffersson analyserar domen. } } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_5, title = {EU-domstolen klargör mervärdesskatteregler vid koncerninterna tjänster – analys}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031835}, language = {swe}, publisher = {JP Infonet}, keywords = {mervärdesskatt; moms}, abstract = {Den 4 september 2025 meddelade EU-domstolen dom i mål C-726/23, Arcomet Towercranes. Målet avser beräkning av ersättningen för koncerninterna tjänster i enlighet med OECD:s riktlinjer, samt kraven på av styrka avdragsrätten med faktura. Domen innehåller principiella ställningstaganden för mervärdesskatten om ersättning som består av en fast och en rörlig del. JP Infonets expert professor Eleonor Kristoffersson analyserar domen.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_6, title = {EU-domstolen klargör sin praxis om tillhandahållande av tjänster och uttagsbeskattning – analys}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031834}, language = {swe}, publisher = {JP Infonet}, keywords = {mervärdesskatt; moms}, abstract = {Den 2 oktober 2025 meddelade EU-domstolen dom i mål C-535/24, Svilosa. Målet gällde anlitande av advokater för indrivning av en fordran till förmån för en annan person. Domen innehåller principiella ställningstaganden i mervärdesskattehänseende om vad som utgör ett tillhandahållande av en tjänst mot ersättning samt under vilka förutsättningar uttagsbeskattning ska ske. JP Infonets expert professor Eleonor Kristoffersson analyserar domen.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_7, title = {EU-domstolen nyanserar betydelsen av slumpmässighet vid bedömning av ersättning för tjänster – analys}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031833}, language = {swe}, publisher = {JP Infonet}, keywords = {mervärdesskatt; moms}, abstract = {En advokat som företräder en klient utan ersättning men enligt lag kan få arvode från motparten anses tillhandahålla en tjänst mot ersättning, enligt EU-domstolen. Domen klargör att slumpmässighet kring betalningen inte i sig bryter det direkta sambandet mellan den utförda tjänsten och ersättningen. JP Infonets expert professor Eleonor Kristoffersson analyserar domen.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_8, title = {EU-domstolen underkänner Skatteverkets metod för omvärdering av koncerninterna tjänster – analys}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031837}, language = {swe}, publisher = {JP Infonet}, keywords = {mervärdesskatt; moms}, abstract = {Den 23 juli 2025 meddelade EU-domstolen dom i C-808/23 Högkullen. Målet avser bestämmandet av marknadsvärdet för tjänster som ett moderbolag tillhandahåller sina dotterbolag inom ramen för sin aktiva förvaltning av dotterbolagen. Rättsligt avser domen artikel 72 och 80 i rådets direktiv 2006/112/EG av den 28 november 2006 om ett gemensamt system för mervärdesskatt (mervärdesskattedirektivet) beträffande beräkning av beskattningsunderlaget. JP Infonets expert professor Eleonor Kristoffersson analyserar domen. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vanrensburgmelissajansen_2025, title = {European Gonococcal Antimicrobial Surveillance Programme Findings 2023}, author = {van Rensburg, Melissa Jansen and Jacobsson, Susanne and Schroder, Daniel and Alexander, Sarah and Ködmön, Csaba and Unemo, Magnus and Cole, Michelle}, year = {2025}, journal = {Sexual Health}, volume = {22}, number = {4}, pages = {19--19}, url = {2036862}, language = {eng}, publisher = {CSIRO Publishing}, abstract = {Background: Treatment options for gonorrhoea are now limited; therefore, surveillance of antimicrobial resistance (AMR) is critical. The European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) monitors AMR trends across the European Economic Area EEA). Here we present key Euro-GASP findings from 2023.Methods: Participating countries collected Neisseria gonorrhoeae isolates from consecutive patients, predominantly between September and November 2023. Susceptibility to ceftriaxone, cefixime, azithromycin, ciprofloxacin, and tetracycline was determined with minimum inhibitory concentration (MIC) gradient strip tests or agar dilution using EUCAST clinical breakpoints. Linked epidemiological data were also provided. The statistical significance of differences in resistance relative to 2022 Euro-GASP results was determined using the Z-test.Results: In 2023, 3184 N. gonorrhoeae isolates were collected from 24 EEA countries. One isolate was resistant to ceftriaxone (compared to two in 2022), which also displayed high-level azithromycin resistance (HL-AziR, MIC >256 mg/L). Cefixime resistance was observed in 0.2% of isolates, which was comparable to 2022 (0.3%, P = 0.212). Azithromycin resistance decreased to 23.1% (25.6% in 2022, P = 0.013); however, 39 isolates from 15 countries exhibited HL-AziR compared to 13 isolates from five countries in 2022. HL-AziR isolates were not restricted to a particular demographic group, although they were more common among men who have sex with men (61.9%). Ciprofloxacin resistance also decreased to 62.7% (65.9%, P = 0.003). Tetracycline susceptibility testing was added to Euro-GASP in 2023, and resistance was at 58.4%.Conclusions: Resistance to ceftriaxone and cefixime remained rare in the EEA in 2023. Azithromycin and ciprofloxacin resistance decreased slightly; however, azithromycin resistance continues to threaten the effectiveness of dual therapy, and the increased number and geographic distribution of HL-AziR isolates is also worrying. The inclusion of tetracycline susceptibility testing in 2023 confirmed that resistance is high in the EEA, providing an important baseline for monitoring the impact of doxycycline post-exposure prophylaxis.}, issn = {1448-5028} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_berglezpeter_2025, title = {European Media Systems in Dynamic Transition : Comparative Results from Five Countries}, author = {Berglez, Peter and Eberwein, Tobias and Krakovsky, Christina and Jansová, Iveta and Miteva, Nadezhda and Nord, Lars and Ots, Mart and Rapado, Irene and Raycheva, Lilia and Rožukalne, Anda and Skulte, Ilva and Waschková Císařová, Lenka}, year = {2025}, journal = {European Journal of Communication}, volume = {40}, number = {5}, pages = {450--470}, doi = {10.1177/02673231251334521}, url = {1957244}, language = {eng}, publisher = {Sage Publications}, keywords = {media change; media systems; europe; media transformation; cross-national comparison}, abstract = {Media in Europe have undergone profound transformations. These changes involve structural transformation (global trends, the role of politics, EU, etc.); sectoral transformation (e.g., deriving from within the media domain), and the role of particular individuals (such as media moguls). In this respect, there is a lack of comparative studies which systematically explore the relations between these three dimensions in European transformative processes. To add new insights to existing knowledge about media systems across parts of Northern, Eastern and Central Europe, the purpose is to compare understandings of media transformation during the last two decades from a structural, sectoral, and individual perspective. 80 interviews were conducted with media experts from Austria, Bulgaria, Czechia, Latvia, and Sweden. The results demonstrate detailed examples of an emerging commonality, with similar changes across Europe, but also consistent differences concerning areas such as the role of history, the pandemic, and geopolitical tensions.}, issn = {0267-3231} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_volgstenulrik_2025_1, title = {European Perspectives on the New Objectivity Movement : Entanglements of Music, Poetics, and Ideas in the Interwar Years}, author = {Volgsten, Ulrik and Zucconi, Benedetta}, year = {2025}, doi = {10.1007/978-3-031-98261-3}, url = {2004999}, language = {eng}, publisher = {Palgrave Macmillan}, abstract = {This edited volume offers a new perspective on the new objectivity movement in music during the interwar period, challenging the view of it as a solely German or Berlin-based movement. Unlike architecture or visual arts, musicology has rarely applied the term beyond Germany. Yet, new objectivity in music—spanning composition, performance, and listening—had significant European expressions. Key features included a rejection of expressionism, interest in mechanical reproduction (radio, gramophone), and objective performance styles. Through historiographical analysis and diverse case studies from several European countries, the book presents the movement as a broader, locally rooted phenomenon reflecting a shared Zeitgeist. It explores how these ideas emerged independently across national contexts, offering new insights into the cultural and political dynamics of the period. By examining aesthetic, institutional, political, and performative dimensions, the book invites a rethinking of new objectivity as a transnational and multifaceted phenomenon, and proposes its relevance as a tool for historiographical inquiry in music studies.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gliksonmichael_2025, title = {European Society of Cardiology (ESC) clinical consensus statement on indications for conduction system pacing, with special contribution of the European Heart Rhythm Association of the ESC and endorsed by the Asia Pacific Heart Rhythm Society, the Canadian Heart Rhythm Society, the Heart Rhythm Society, and the Latin American Heart Rhythm Society}, author = {Glikson, Michael and Burri, Haran and Abdin, Amr and Cano, Oscar and Curila, Karol and De Pooter, Jan and Diaz, Juan C. and Drossart, Inga and Huang, Weijian and Israel, Carsten W. and Jastrzębski, Marek and Joza, Jacqueline and Karvonen, Jarkko and Keene, Daniel and Leclercq, Christophe and Mullens, Wilfried and Pujol-Lopez, Margarida and Rao, Archana and Vernooy, Kevin and Vijayaraman, Pugazhendhi and Zanon, Francesco and Michowitz, Yoav and Nielsen, Jens Cosedis and Boersma, Lucas and Blomström-Lundqvist, Carina and Kronborg, Mads Brix and Chung, Mina K. and Tse, Hung Fat and Khan, Habib Rehman and Leyva, Francisco and Rojel-Martinez, Ulises and Ruciński, Marcin and Varma, Niraj}, year = {2025}, journal = {Europace}, volume = {27}, number = {4}, doi = {10.1093/europace/euaf050}, url = {1949995}, language = {eng}, publisher = {Oxford University Press}, keywords = {biventricular pacing; cardiac resynchronization therapy; conduction system pacing; his bundle pacing; indications; left bundle branch area pacing}, abstract = {Conduction system pacing (CSP) is being increasingly adopted as a more physiological alternative to right ventricular and biventricular pacing. Since the 2021 European Society of Cardiology pacing guidelines, there has been growing evidence that this therapy is safe and effective. Furthermore, left bundle branch area pacing was not covered in these guidelines due to limited evidence at that time. This Clinical Consensus Statement provides advice on indications for CSP, taking into account the significant evolution in this domain.}, issn = {1099-5129} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_garciaargibaymiguel_2025, title = {Evaluating ADHD medication trial representativeness : a Swedish population-based study comparing hypothetically trial-eligible and trial-ineligible individuals}, author = {Garcia-Argibay, Miguel and Chang, Zheng and Brikell, Isabell and Kuja-Halkola, Ralf and D'Onofrio, Brian M. and Lichtenstein, Paul and Newcorn, Jeffrey H. and Faraone, Stephen V. and Larsson, Henrik and Cortese, Samuele}, year = {2025}, journal = {Lancet psychiatry}, volume = {12}, number = {2}, pages = {131--139}, doi = {10.1016/S2215-0366(24)00396-1}, url = {1924543}, language = {eng}, publisher = {Elsevier}, abstract = {Background: Randomised controlled trials (RCTs) evaluating ADHD medications often use strict eligibility criteria, potentially limiting generalisability to patients in real-world clinical settings. We aimed to identify the proportion of individuals with ADHD who would be ineligible for medication RCTs and evaluate differences in treatment patterns and clinical and functional outcomes between RCT-eligible and RCT-ineligible individuals.Methods: We used multiple Swedish national registries to identify individuals with ADHD, aged at least 4 years at the age of diagnosis, initiating pharmacological treatment between Jan 1, 2007, and Dec 31, 2019, with follow-up up to Dec 31, 2020. Hypothetical RCT ineligibility was established using exclusion criteria from the international MED-ADHD dataset, including 164 RCTs of ADHD medications. Cox models evaluated differences in medication switching and discontinuation within 1 year between eligible and ineligible individuals. Quasi-Poisson models compared eligible and ineligible individuals on rates of psychiatric hospitalisations, injuries or accidents, and substance use disorder within 1 year of initiating ADHD medications. People with lived experience of ADHD were not involved in the research and writing process.Findings: Of 189 699 individuals included in the study cohort (112 153 men and boys [59%] and 77 546 women and girls [41%]; mean age 21·52 years [SD 12·83; range 4–68]) initiating ADHD medication, 53% (76 477 [74%] of 103 023 adults [aged >17 years], 12 658 [35%] of 35 681 adolescents [aged 13–17 years], and 10 643 [21%] of 50 995 children [aged <13 years]) would have been ineligible for RCT participation. Ethnicity data were not available. Ineligible individuals had a higher likelihood of treatment switching (hazard ratio 1·14, 95% CI 1·12–1·16) and a decreased likelihood of medication discontinuation (0·96, 0·94–0·98) compared with eligible individuals. Individuals ineligible for RCTs had significantly higher rates of psychiatric hospitalisations (ncidence rate ratio 9·68, 95% CI 9·57–9·78) and specialist care visits related to substance use disorder (14·78, 14·64–14·91), depression (6·00, 5·94–6·06), and anxiety (11·63, 11·56–11·69).Interpretation: Individuals ineligible for ADHD medication trials face higher risks of adverse outcomes. This study provides the first empirical evidence for the limited generalisability of ADHD RCTs to real-world clinical populations, by applying eligibility criteria extracted from a comprehensive dataset of RCTs to a large real-world cohort. Triangulating evidence from RCTs and real-world studies is crucial to inform rigorous evidence-based treatment guidelines.}, issn = {2215-0374} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_holmsebastian_2025_1, title = {Evaluating Artificial Intelligence's Role in Developing Research Questions in Head and Neck Reconstruction}, author = {Holm, Sebastian and Zambrana, Mario and Berner, Juan E. and Tabrisi, Reza and Landström, Fredrik and Hanoon, Dhafir and Zdolsek, Johann}, year = {2025}, journal = {Plastic and Reconstructive Surgery - Global Open}, volume = {13}, number = {8}, doi = {10.1097/GOX.0000000000007057}, url = {1990104}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, abstract = {Generative artificial intelligence (AI) large language models are an emerging technology, with ChatGPT and Gemini being 2 well-known examples. The current literature discusses clinical applications and limitations of AI, but its role in research has not yet been extensively evaluated. This study aimed to assess the role of ChatGPT and Gemini in developing novel and clinically relevant research ideas (RIs) for systematic reviews (SRs) in head and neck reconstruction. ChatGPT and Gemini were prompted to provide 10 novel and clinically relevant RIs for SRs in the following domains: head and neck reconstruction in general, microsurgery, and complications in reconstructive head and neck procedures. A comprehensive search was then performed for SRs in MEDLINE, Cochrane Library, and Embase to determine the novelty of the RIs generated. A total of 60 RIs were generated, with half created by ChatGPT and the other half by Gemini. Overall, 3613 entries were found through the literature search. After deduplication and screening, a total of 50 studies that partially addressed the AI-generated RIs were identified and were included in the present review. Out of the 60 AI-generated RIs, 42 had not been previously studied and were therefore considered novel. No statistically significant differences were found between the outputs generated by Gemini and ChatGPT. Both ChatGPT and Gemini were able to effectively generate novel and clinically relevant RIs for SRs, although their suggestions were generally broad. This study demonstrated that AI could potentially aid in the process of conducting novel SRs.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_schreitertim_2025, title = {Evaluating Efficiency and Engagement in Scripted and LLM-Enhanced Human-Robot Interactions}, author = {Schreiter, Tim and Rüppel, Jens V. and Hazra, Rishi and Rudenko, Andrey and Magnusson, Martin and Lilienthal, Achim J.}, year = {2025}, pages = {1608--1612}, doi = {10.1109/HRI61500.2025.10974124}, url = {2013097}, language = {eng}, publisher = {IEEE}, keywords = {human-robot interaction; ai-enabled robotics}, abstract = {To achieve natural and intuitive interaction with people, HRI frameworks combine a wide array of methods for human perception, intention communication, human-aware navigation and collaborative action. In practice, when encountering unpredictable behavior of people or unexpected states of the environment, these frameworks may lack the ability to dynamically recognize such states, adapt and recover to resume the interaction. Large Language Models (LLMs), owing to their advanced reasoning capabilities and context retention, present a promising solution for enhancing robot adaptability. This potential, however, may not directly translate to improved interaction metrics. This paper considers a representative interaction with an industrial robot involving approach, instruction, and object manipulation, implemented in two conditions: (1) fully scripted and (2) including LLM-enhanced responses. We use gaze tracking and questionnaires to measure the participants' task efficiency, engagement, and robot perception. The results indicate higher SUbjective ratings for the LLM condition, but objective metrics show that the scripted condition performs comparably, particularly in efficiency and focus during simple tasks. We also note that the scripted condition may have an edge over LLM-enhanced responses in terms of response latency and energy consumption, especially for trivial and repetitive interactions.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_khanlubna_2025, title = {Evaluating Gulf Cooperation Council Trauma Care Infrastructure : A Scoping Review of Key Components and Gaps}, author = {Khan, Lubna and Karim, Abbas and Bey, Hachem and Alzaid, Saud Naji and Al-Qadhi, Hani Ahmed and Alabboudi, Yousif Habib and Peralta, Ruben and Bakry, Husham and Nouh, Thamer and Mohseni, Shahin and Mashbari, Hassan}, year = {2025}, journal = {World Journal of Surgery}, volume = {49}, number = {10}, pages = {2921--2932}, doi = {10.1002/wjs.70019}, url = {1988973}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {injury; prehospital care; rehabilitation; trauma care delivery; trauma systems}, abstract = {Background: Trauma systems are multifaceted frameworks that optimize patient care and outcomes. The development of trauma systems has been a regional priority in the Gulf Cooperation Council (GCC), yet implementation varies across countries. These variations contribute to measurable differences in system performance and patient outcomes. A systematic mapping of these disparities can guide efforts to harmonize standards and enhance trauma-care delivery throughout the region.Methods: A scoping review was conducted per PRISMA-ScR guidelines. PubMed, Scopus, and the Cochrane Library databases were searched for English-language publications (2000-2024) on prehospital emergency care, hospital-based trauma management, or post-hospital rehabilitation in GCC countries. Two reviewers independently screened and charted eligible studies; articles addressing only clinical outcomes without system-level discussion were excluded. Gray literature sources included Ministry of Health (MOH) websites, local news reports, and expert opinion.Results: Of 1758 studies, 51 were fully screened, and 43 met the inclusion criteria. All GCC countries, except for UAE, operate a single centralized EMS system via a uniform national emergency number. Fleet sizes range from 36 ambulances in Bahrain to over 1379 in Saudi Arabia, with mean response times ranging from 5.3 min in Qatar to 15 min nationally in Kuwait. Formal trauma centers are limited in the region: Bahrain has no formal trauma centers, Qatar and Kuwait each have one dedicated trauma center (level 1 and 2 equivalent, respectively), Oman has two (level 2 and level 3 equivalent), Saudi Arabia has two (level 1 equivalent), and the UAE has nine (levels 1-3 equivalent). Local trauma registries exist in all countries, with a national trauma registry only in Qatar. Posthospital rehabilitation, although variable in resources, is delivered through MOH networks in all countries and supplemented by private providers.Conclusion: Despite progress, gaps persist in trauma center accreditations, national registry development, and formation of integrated rehabilitation networks. Concerted improvements could further enhance trauma care delivery in the region with a desired improvement in overall outcomes.}, issn = {0364-2313} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_guptahimanshu_2025, title = {Evaluating LiDAR Perception Algorithms for All-Weather Autonomy}, author = {Gupta, Himanshu and Lilienthal, Achim J. and Andreasson, Henrik}, year = {2025}, journal = {Sensors}, volume = {25}, number = {24}, doi = {10.3390/s25247436}, url = {2025984}, language = {eng}, publisher = {MDPI}, keywords = {3d object detection; lidar perception; slam; adverse weather; localization; point cloud filter}, abstract = {LiDAR is used in autonomous driving for navigation, obstacle avoidance, and environment mapping. However, adverse weather conditions introduce noise into sensor data, potentially degrading the performance of perception algorithms and compromising the safety and reliability of autonomous driving systems. Hence, in this paper, we investigate the limitations of LiDAR perception algorithms in adverse weather conditions, explore ways to mitigate the effects of noise, and propose future research directions to achieve all-weather autonomy with LiDAR sensors. Using real-world datasets and synthetically generated dense fog, we characterize the noise in adverse weather such as snow, rain, and fog; their effect on sensor data; and how to effectively mitigate the noise for tasks like object detection, localization, and SLAM. Specifically, we investigate point cloud filtering methods and compare them based on their ability to denoise point clouds, focusing on processing time, accuracy, and limitations. Additionally, we evaluate the impact of adverse weather on state-of-the-art 3D object detection, localization, and SLAM methods, as well as the effect of point cloud filtering on the algorithms' performance. We find that point cloud filtering methods are partially successful at removing noise due to adverse weather, but must be fine-tuned for the specific LiDAR, application scenario, and type of adverse weather. 3D object detection was negatively affected by adverse weather, but performance improved with dynamic filtering algorithms. We found that heavy snowfall does not affect localization when using a map constructed in clear weather, but it fails in dense fog due to a low number of feature points. SLAM also failed in thick fog outdoors, but it performed well in heavy snowfall. Filtering algorithms have varied effects on SLAM performance depending on the type of scan-matching algorithm.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_oreillylaurenm_2025, title = {Evaluating Machine Learning for Predicting Youth Suicidal Behavior up to 1 Year After Contact With Mental-Health Specialty Care}, author = {O'Reilly, Lauren M. and Fazel, Seena and Rickert, Martin E. and Kuja-Halkola, Ralf and Martin, Cederlöf and Hellner, Clara and Larsson, Henrik and Lichtenstein, Paul and D'Onofrio, Brian M.}, year = {2025}, journal = {Clinical Psychological Science}, volume = {13}, number = {3}, pages = {614--631}, doi = {10.1177/21677026241301298}, url = {1928214}, language = {eng}, publisher = {Sage Publications}, keywords = {suicide prevention; adolescent development; open materials}, abstract = {In this article, we assessed the performance of several predictive modeling algorithms of suicide attempt resulting in inpatient hospitalization or suicide among youths ages 9 to 18 (N = 34,528) after contact (6-12 months) with a mental-health specialist in Stockholm, Sweden, from 2006 to 2012. Using 209 predictors across domains (e.g., clinical, demographic, family, neighborhood, social) identified from national registers, we applied standard logistic regression, regularized logistic regression, and machine-learning algorithms (i.e., random forests, gradient boosting, support vector machines). Standard logistic regression (area under the receiver operating characteristic curve [AUC] = 0.77, 95% confidence interval [CI] = [0.72, 0.82]) and random-forest models (AUC = 0.80, 95% CI = [0.74, 0.86]) demonstrated the highest AUCs. Sensitivities ranged from 0.33 (support vector machines) to 0.91 (standard logistic regression). Although the study was underpowered to detect a difference between logistic regression and machine-learning algorithms (outcome prevalence = 0.7%), performance metrics were similar across models. Logistic regression is not clearly worse than machine-learning approaches. Ongoing research is needed to examine how prediction models can augment clinical decision-making.}, issn = {2167-7026} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_engelhardtjosefin_2025, title = {Evaluating the Endocrine-Disrupting and Oxidative Stress Potential of a 50-Component Human-Relevant Complex Chemical Mixture Using In Vitro Tests}, author = {Engelhardt, Josefin and Struwe, Nathalie and Jansson, Annika and Kos, Vesna Munic and Larsson, Maria and Weiss, Jana M.}, year = {2025}, journal = {Journal of Applied Toxicology}, doi = {10.1002/jat.70011}, url = {2017576}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {calux; chemical mixtures; concentration additivity; endocrine‐disrupting chemicals; environmental contaminants; human blood concentrations; in vitro; oxidative stress}, abstract = {Humans are chronically exposed to mixtures of environmental contaminants. Exposure to endocrine-disrupting chemicals (EDCs) contributes to increased health impairment observed globally. This study aimed to evaluate the endocrine-disruptive and oxidative stress potential of a human-relevant, complex chemical mixture in vitro. By testing chemical class subgroup mixtures, the identity of toxicological drivers and mixture additivity could be investigated. A 50-component mixture was compiled based on Swedish human blood concentrations (xHBC), consisting of six subgroup mixtures: polychlorinated biphenyls (PCBs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (PCB mixture), brominated flame retardants (BFR mixture), per- and polyfluoroalkyl substances (PFAS mixture), pesticide mixture, synthetic phenolic contaminants (phenol mixture), and phthalate mixture. These were tested in four chemically activated luciferase gene expression (CALUX) assays: dioxin responsive (DR-), estrogen receptor α (ERα-), androgen receptor. (AR-), and nuclear factor erythroid 2-related factor 2 (Nrf2)-CALUX, along with an adipocyte cell assay. The total mixture caused significant agonistic activity in DR- and ER-, and antagonistic activity in AR-CALUX at 0.1-15 xHBC, depending on the assay. Mixture additivity was assessed in ERα-, DR-, and anti-AR-CALUX using subgroup mixtures and the concentration addition (CA) model. The total mixture followed the CA model in ERα-, anti-AR- and DR-CALUX. The toxicological drivers of these activities were mainly the PCB and phenol mixture. A significant increase in differentiated adipocytes was observed at 100 xHBC. These results raise concerns regarding potential health effects on the endocrine system. The additive effects at human-relevant concentrations observed in this study motivate considering mixtures in regulatory contexts to protect the well-being of future generations.}, issn = {0260-437X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_yuliang_2025, title = {Evaluating the quality of GenAI applications in software engineering : a multi-case study}, author = {Yu, Liang and Alégroth, Emil and Chatzipetrou, Panagiota and Gorschek, Tony}, year = {2025}, journal = {Empirical Software Engineering}, volume = {31}, number = {2}, doi = {10.1007/s10664-025-10759-2}, url = {2028988}, language = {eng}, publisher = {Springer}, keywords = {generative artificial intelligence; genai; large language model; llm; metric; quality evaluation}, abstract = {Context: Generative AI (GenAI) is increasingly adopted in software development for tasks such as document generation, data analysis, and code generation. However, evaluating the quality of GenAI applications becomes challenging, as traditional quality measurements may not be fully applicable.Objective: In this study, we explore how practitioners evaluate the quality of GenAI applications and investigate quality evaluation techniques.Method: We conducted a multi-case study in three industrial projects from software development companies. We examined four GenAI application domains: document generation, data analysis and insight generation, customer service, and code generation. Data were collected through three workshops and 23 semi-structured interviews with industrial practitioners.Results: We identified fourteen GenAI use cases and 28 metrics currently used to evaluate the quality of GenAI applications' outputs. We synthesized the identified metrics' usage patterns and challenges based on the collected data.Conclusions: This study presents practical insights into using metrics to measure GenAI-based system qualities in real industrial settings. Our findings indicate that practitioners use custom-built and context-specific metrics; combining these with academic metrics can strengthen GenAI system quality evaluation.}, issn = {1382-3256} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_holmefurmarie_2025, title = {Evaluation of a home-based parenting support programme-Parenting Young Children-For parents with intellectual and developmental disabilities when there is a risk for neglect : Study protocol for a multi-centre study}, author = {Holmefur, Marie and Forslund, Tommie and Randell, Eva and Wennberg, Birgitta and Ayoub, Maria and Almqvist, Lena and Fängström, Karin and Janeslätt, Gunnel and Strandberg, Thomas}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {2}, doi = {10.1371/journal.pone.0318447}, url = {1936512}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {INTRODUCTION: Parents with intellectual and developmental disabilities (IDDs) often need parenting support, but there are few evidence-based programmes adapted to their cognitive needs. Parenting Young Children (PYC), a home-based programme for parents with IDDs, is perceived as beneficial by parents and practitioners, but it is unclear if PYC improves parenting. The purpose of the proposed mixed-methods study is therefore to evaluate the PYC programme for improved parenting in parents with IDDs.METHODS AND ANALYSIS: The quantitative evaluation will have a multi-centre, pretest-posttest study design and include parents with IDDs (children aged 0-9) in need of adapted parenting support. Goal-attainment in parenting skills, parental self-efficacy and child mental health will be measured outcomes. Interviews will be used to explore the perspectives of parents and children on PYC.ETHICS AND DISSEMINATION: Particpation is based on informed consent from parents and guardians of the participating children. Ethical approval was granted by the Swedish Ethical Review Authority.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_zeinermichaela_2025_3, title = {Evaluation of Cadmium and Lead Contamination in Wild Dandelion (Taraxacum officinale) from Croatia : Implications for Food Safety and Public Health}, author = {Zeiner, Michaela and Ilić, Nikolina and Juranović Cindrić, Iva and Nemet, Ivan and Fiedler, Heidelore}, year = {2025}, url = {1940006}, language = {eng}, abstract = {Dandelion (Taraxacum officinale) often considered a weed is a highly versatile and beneficial plant that has been used in food, medicine, and as a natural remedy for centuries.Soil pollution by potentially toxic elements is of concern since they may transfer to the edible parts of the food, especially when collecting wild plants from not cultivated, and thus not controlled soil. As examples, cadmium and lead are heavy metals that can accumulate in the body over time, leading to a range of adverse health outcomes.The European Food Safety Authority (EFSA) stipulated maximum mass fractions of certain metals in food stuff, e.g. 0.05 mg/kg and 0.1 mg/kg for cadmium (Cd) and lead (Pb), respectively. Cadmium is primarily absorbed in the gastrointestinal tract when ingested through food. It is then distributed throughout the body, where it binds to proteins and accumulates in various tissues, particularly the kidneys, liver, and bones. Lead is absorbed into the body through the gastrointestinal tract and is distributed to the bloodstream, where it can accumulate in various tissues, including the bones, brain, and kidneys.Dandelion and soil samples were collected at 19 different places in Croatia, divided into different parts (root, stem, leaf, flower); thus, generating a total of 95 samples. The plant parts were washed with diluted nitric acid, dried at 105 °C, and ground for homogenisation prior to acidic microwave assisted digestion. The quantification of selected potentially toxic elements in the clear digest solutions was carried out using inductively coupled plasma mass spectrometry (ICP-MS). Soil samples were air-dried and pulverized using an agate mortar prior to digestion and analysis. All plant samples had Pb mass fractions above the maximum value, the results ranging from 0.116 mg/kg to 2.39 mg/kg for the flowers, 0.272 mg/kg to 13.9 mg/kg for the leaves, 0.217 mg/kg to 3.56 mg/kg for the stem, and from 0.745 mg/kg to 40.4 mg/kg for the roots. Regarding Cd, all values except for flower and stem in two plants and four flowers exceeded the maximum mass fraction. On the contrast only five soils samples exceeded the World Health Organization (WHO) permissible limit of heavy metals in soil for Cd and only one for Pb.The elevated levels of Cd and Pb in wild edible plants may pose a public health concern due to the exceedance of recommended limit values. In conclusion of this study, the present dandelion samples cannot be recommended for human consumption.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_galavazimarije_2025, title = {Evaluation of clinical benefits and economic value of weight loss in a Swedish population using a simulation model}, author = {Galavazi, Marije and Wallenius, Ville and Schnecke, Volker and Ericsson, Åsa and Björklund, Helena and Jendle, Johan}, year = {2025}, journal = {Obesity}, volume = {33}, number = {4}, pages = {777--787}, doi = {10.1002/oby.24232}, url = {1944281}, language = {eng}, publisher = {John Wiley & Sons}, abstract = {OBJECTIVE: The objective of this study was to estimate the 10-year clinical benefits and economic value of weight loss in a Swedish population with obesity using a value of weight-loss simulation model.METHODS: Data on the prevalence of and costs associated with obesity and obesity-related complications (ORCs) were applied within an adapted simulation model to evaluate weight-loss benefits for a 2023 Swedish population over 10 years. The 10-year incidence of 10 ORCs and treatment costs in a random cohort of 10,000 individuals were estimated for a stable weight scenario and four weight-loss (5%-20%) scenarios.RESULTS: The model included 887,272 individuals with obesity aged 20 to 60 years. Hypertension (24.1%), asthma (20.9%), dyslipidemia (18.3%), and type 2 diabetes (10.6%) were highly prevalent. For 10,000 individuals, a 5% to 20% weight loss was estimated to prevent ORCs over 10 years, leading to annual savings between 9.0 million Swedish krona (SEK)/€0.8 million (5% weight loss) and 30.0 million SEK/€2.6 million (20%) by 2033.CONCLUSIONS: Annual treatment costs of ORCs in Sweden will double over 10 years, and weight loss would be associated with significant savings because of the reductions in the incidence of ORCs. Therefore, there is an urgent need to effectively treat obesity to prevent morbidity.}, issn = {1930-7381} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_mironenkoolga_2025, title = {Evaluation of Coordination Strategies for Underground Automated Vehicle Fleets in Mixed Traffic}, author = {Mironenko, Olga and Banaee, Hadi and Loutfi, Amy}, year = {2025}, pages = {1020--1026}, doi = {10.1109/IV64158.2025.11097685}, url = {1987729}, language = {eng}, publisher = {IEEE}, keywords = {mixed traffic with fleets of automated vehicles; path overlap density (pod); human behavior in driving; centralized coordination; coordination strategies; underground mining}, abstract = {This study investigates the efficiency and safety outcomes of implementing different adaptive coordination models for automated vehicle (AV) fleets, managed by a centralized coordinator that dynamically responds to human-controlled vehicle behavior. The simulated scenarios replicate an underground mining environment characterized by narrow tunnels with limited connectivity. To address the unique challenges of such settings, we propose a novel metric — Path Overlap Density (POD) — to predict efficiency and potentially the safety performance of AV fleets. The study also explores the impact of map features on AV fleets performance. The results demonstrate that both AV fleet coordination strategies and underground tunnel network characteristics significantly influence overall system performance. While map features are critical for optimizing efficiency, adaptive coordination strategies are essential for ensuring safe operations. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hallbckerikatng_2025, title = {Evaluation of nationwide analysis surveillance for methicillin-resistant Staphylococcus aureus within Genomic Medicine Sweden}, author = {Hallbäck, Erika Tång and Björkman, Jonas T. and Dyrkell, Fredrik and Welander, Jenny and Fang, Hong and Sylvin, Isak and Kaden, René and Eilers, Hinnerk and Strand, Anna Söderlund and Mernelius, Sara and Berglind, Linda and Campillay Lagos, Amaya and Engstrand, Lars and Sikora, Per and Mölling, Paula}, year = {2025}, journal = {Microbial Genomics}, volume = {11}, number = {1}, doi = {10.1099/mgen.0.001331}, url = {1942040}, language = {eng}, publisher = {Microbiology Society}, keywords = {cgmlst; genomic medicine sweden; mrsa; snp; whole- genome sequencing}, abstract = {Background: National epidemiological investigations of microbial infections greatly benefit from the increased information gained by whole- genome sequencing (WGS) in combination with standardized approaches for data sharing and analysis.Aim: To evaluate the quality and accuracy of WGS data generated by different laboratories but analysed by joint pipelines to reach a national surveillance approach.Methods: A national methicillin- resistant Staphylococcus aureus (MRSA) collection of 20 strains was distributed to nine participating laboratories that performed in- house procedures for WGS. Raw data were shared and analysed by three pipelines: 1928 Diagnostics, JASEN (GMS pipeline) and CLC- Genomics Workbench. The outcomes were compared according to quality, correct strain identification and genetic distances.Results: One isolate contained intraspecies contamination and was excluded from further analysis. The mean sequencing depth varied between sites and technologies. However, all analysis methods identified 12 strains that belonged to one of five outbreak clusters. The cut- off definition was set to <10 allele differences for core genome multilocus sequence typing (cgMLST) and <20 genetic differences for SNP analysis in a pairwise comparison.Conclusions: MRSA isolates, which are whole genome sequenced by different laboratories and analysed using the same bioinformatic pipelines, yielded comparable results for outbreak clustering for both cgMLST and SNP, using the 1928 analysis pipeline. In this study, JASEN was best suited to analyse Illumina data and CLC to analyse within respective technology. In the future, real- time sharing of data and harmonized analysis within the Genomic Medicine Sweden consortium will further facilitate investigations of outbreaks and transmission routes.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_wingrenmaria_2025, title = {Evaluation of the time management intervention Let's Get Organized : Effectiveness, sustainability over time, and parenting perspectives}, author = {Wingren, Maria}, year = {2025}, url = {1967012}, language = {eng}, publisher = {Örebro University}, keywords = {time management skills; organization and planning; intervention; parenting; parental self-efficacy}, abstract = {Introduction: Time management skills are crucial in daily life—at home, to maintain employment, and in parenting—posing a challenge for people with impaired executive functioning. To improve time management skills, individual occupational therapy is commonly offered. The occupational therapy group intervention Let’s Get Organized (LGO) includes ten weekly sessions with a focus on time management skills; it has shown promising results but needs to be further evaluated. Aim: The overall aim of this thesis was to evaluate the time management group intervention LGO for people with ADHD, autism, or mental disorders regarding effectiveness, sustainability over time, and parenting perspectives. Method: LGO was evaluated in four studies with different designs: a multi-center, two-armed, randomized controlled trial including 75 participants who were randomized to LGO or individual occupational therapy (Study I); a single-group one-year follow-up study including 38 participants (Study II); a study including data from the participants in Study I who were parents (n = 28, Study III); and a qualitative interview study with parents after intervention (n = 15, Study IV). To analyze the data, non-parametric tests, a mixed-effects model, correlation testing, and inductive qualitative content analysis were used. Results: Time management skills improved in both groups (LGO and individual occupational therapy) with no difference between them (Study I). Additionally, organization and planning skills and emotional regulation improved after intervention in both groups (Study I). The improved time management skills achieved after LGO were sustained one year after intervention (Study II). Parents improved significantly in parental self-efficacy after time management interventions with no difference betweenthe type of intervention (Study III). Parents experienced more active parenting and better predictability in the whole family after participating in LGO (Study IV). Conclusion: Time management interventions improve time management skills; the improvement is sustained over the long term and moreover has a positive impact on parenting.}, file = {https://oru.diva-portal.org/smash/get/diva2:1967012/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vigfssonhannesbjarki_2025, title = {Evaluation of three commercial rapid immunoassays for the diagnosis of Clostridioides difficile infection}, author = {Vigfússon, Hannes Bjarki and Ennefors, Theresa and Norén, Torbjörn and Sundqvist, Martin}, year = {2025}, journal = {Microbiology Spectrum}, volume = {13}, number = {8}, doi = {10.1128/spectrum.03405-24}, url = {1986223}, language = {eng}, publisher = {American Society for Microbiology}, keywords = {clostridioides difficile; diagnosis; rapid immunoassays; clostridioides difficile infection}, abstract = {Current guidelines recommend the use of a two-step algorithm for the laboratory diagnosis of Clostridioides difficile infection (CDI). Several commercial rapid immunoassays that detect both GDH and toxin A/B in stool samples are available and could be used for both steps of the diagnostic algorithm. We aimed to evaluate the performance of three of these rapid immunoassays and study pathogen characteristics that might affect the sensitivity of toxin A/B detection. Leftover material from routinely collected stool samples from patients suspected of CDI was analyzed with the three immunoassays, nucleic acid amplification test (NAAT), and culture. Whole-genome sequencing was then used to evaluate C. difficile isolates recovered from the samples. The positive percent agreement between GDH detection and detection of tcdA by NAAT was 100% with all three immunoassays. The positive percent agreement for the detection of toxin A/B, however, was considerably lower (50.0%, 51.7%, and 71.4%), and freezing stool samples seemed to negatively affect the detection of both GDH and toxins. The isolates included in the study belonged to 23 different sequence types (ST) and all carried the tcdA and tcdB genes. The C. diff Quik Chek Complete performed the best of the three immunoassays, and when used in combination with NAAT, is a viable option for the laboratory diagnosis of CDI.IMPORTANCE: Laboratory diagnosis of Clostridioides difficile infection is complex, and current guidelines recommend a two-step diagnostic algorithm with a sensitive screening test and a more specific confirmatory test. The study aimed to evaluate three commercial rapid immunoassays that detect both glutamate dehydrogenase (GDH) and toxins A and B. These tests could be used for both steps of the two-step diagnostic algorithm and facilitate rapid laboratory confirmation of CDI, which is important for clinical decision-making and infection control measures.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hllebergnymanmaria_2025, title = {Evidence-based and person-centred bladder care for patients in hip surgery – are fundamentals met in orthopaedic nursing?}, author = {Hälleberg Nyman, Maria and Sköld, Patricia and Winberg, Madeleine and Fjordkvist, Erika and Bendtsen, Markus and Joelsson-Alm, Eva and Eldh, Ann Catrine}, year = {2025}, url = {1950044}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_elhajjvictorgabriel_2025_1, title = {Evolution of Patient-Reported Outcome Measures After Surgery for Degenerative Cervical Spine Disease : Do 1-year PROMs Reflect Longer Term Outcomes?}, author = {El-Hajj, Victor Gabriel and Kjaerbeck, Cecilia and Staartjes, Victor E. and Edström, Erik and Elmi-Terander, Adrian}, year = {2025}, journal = {Neurosurgery}, doi = {10.1227/neu.0000000000003886}, url = {2023926}, language = {eng}, publisher = {Wolters Kluwer}, keywords = {cervical spondylosis; proms; patient-reported outcome measures; spine surgery}, abstract = {BACKGROUND AND OBJECTIVES: Patient-reported outcome measures (PROMs) are today's gold standard outcomes in surgery for degenerative cervical spine disorders. Long-term outcome research may be limited by missing data at later follow-up time-points. Previous studies on lumbar disorders suggest that no significant changes to PROMS occur after 1-year postsurgery. However, no previous study has examined the evolution of PROMS after surgery for degenerative cervical spine disease. We hence aimed to study the evolution of PROMs at 1, 2, and 5 years of postoperative follow-up in patients with cervical spondylosis treated for degenerative radiculopathy or myelopathy.METHODS: A total of 6467 patients (4785 radiculopathy and 1682 myelopathy) undergoing surgery for cervical spondylosis between 2006 and 2018 in Sweden were included. Prerequisites for inclusion were PROMs at 1 and 2 or 5 years. The evolution of PROMs over time, the correlation between 1-year PROMs and 2- or 5-year PROMs and the predictive capability of 1-year PROMs were assessed.RESULTS: No significant changes in PROMs beyond 1-year postoperatively could be observed among both degenerative radiculopathy and myelopathy cohorts (P ≥ .05). Significant (P < .0001) moderately strong to strong correlations were found between 1-year and 2- or 5-year PROMs (Pearson's R ranging from 0.56 to 0.85). On univariable analysis, 1-year PROMs were found to be strong predictors of long-term outcomes (P < .0001).CONCLUSIONS: After surgery for cervical spondylosis with either degenerative radiculopathy or myelopathy, PROMs remained stable beyond 1 year, with minimal changes occurring thereafter. 1-year PROMs correlated with and served as a good proxy for predicting 2- and 5-year PROMs. This suggests that on a population level, 1-year PROMs are sufficient to assess longer term outcomes.}, issn = {0148-396X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_chuateckphui_2025, title = {Evolving patterns of macrolide and fluoroquinolone resistance in Mycoplasma genitalium : an updated systematic review and meta-analysis}, author = {Chua, Teck-Phui and Vodstrcil, Lenka A. and Murray, Gerald L. and Plummer, Erica L. and Jensen, Jørgen S. and Unemo, Magnus and Chow, Eric P. F. and Low, Nicola and Whiley, David M. and Sweeney, Emma L. and Hocking, Jane S. and Danielewski, Jennifer A. and Garland, Suzanne M. and Fairley, Christopher K. and Zhang, Lei and Bradshaw, Catriona S. and Machalek, Dorothy A.}, year = {2025}, journal = {The Lancet Microbe}, volume = {6}, number = {7}, doi = {10.1016/j.lanmic.2024.101047}, url = {1948222}, language = {eng}, publisher = {Elsevier}, abstract = {BACKGROUND: Over the past 5 years, since publication of the initial review, studies have provided additional data on macrolide and fluoroquinolone resistance in Mycoplasma genitalium, including data from regions previously lacking this information. We aimed to provide contemporary estimates of macrolide and fluoroquinolone resistance in M genitalium to inform national, regional, and global treatment guidelines.METHODS: This is an update of a previous systematic review and meta-analysis, which was performed up to Jan 7, 2019. In this update, we searched PubMed, Embase, and MEDLINE from Jan 1, 2018, to April 18, 2023, for published studies reporting macrolide, fluoroquinolone, or dual-class (macrolide and fluoroquinolone) resistance in M genitalium. Data were combined with the previous meta-analysis to examine resistance prevalence in M genitalium samples collected up to and including 2021. Random-effects meta-analyses were used to calculate summary estimates of prevalence. Subgroup analyses by WHO region and four time periods (before 2012 to 2018-21) were performed. This study was registered with PROSPERO, number CRD42021273340.FINDINGS: 166 studies (59 from the previous search period reporting data from M genitalium samples collected between 2003 and 2017, and 107 from the updated search period reporting data from M genitalium samples collected between 2005 and 2021) were included: 157 reporting macrolide resistance (41 countries; 22 974 samples), 89 reporting fluoroquinolone resistance (35 countries; 14 165 samples), and 74 reporting dual-class resistance (34 countries; 11 070 samples). In 2018-21, the overall prevalence of macrolide, fluoroquinolone, and dual-class resistance were 33·3% (95% CI 27·2-39·7), 13·3% (10·0-17·0), and 6·5% (4·0-9·4), respectively. Over time, there was a slight, although not statistically significant, decline in macrolide resistance in the Western Pacific and the Americas, but there was an increase in macrolide resistance in the European region. Fluoroquinolone resistance was highest in the Western Pacific and increased in the European non-Nordic region. ParC S83I was the most common variant associated with fluoroquinolone resistance, increasing from 0% (95% CI <0·0001-0·30) before 2012 to 7·3% (4·7-10·3) in 2018-21; ptrend=0·055.INTERPRETATION: Macrolide and fluoroquinolone resistance in M genitalium requires ongoing international surveillance, use of resistance assays for optimal antibiotic stewardship, and novel treatment options.}, issn = {2666-5247} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lizanocheryl_2025, title = {Examining preservice teachers’ bar model representations for solving word problems involving fractions}, author = {Lizano, Cheryl and Sevinc, Serife}, year = {2025}, journal = {Journal of Mathematics Teacher Education}, doi = {10.1007/s10857-025-09731-0}, url = {2006028}, language = {eng}, publisher = {Springer}, keywords = {bar model; preservice teacher education; fractions; problem-solving heuristic}, abstract = {The purpose of this mixed methods study is to explore elementary preservice teachers’ (PSTs’) use of bar models for solving problems involving fractions. As part of a larger pro-ject, a sample of 17 PSTs’ written work for 10 word problems was analyzed. A mediation analysis showed that bar model correctness had a direct effect on overall solution correct-ness, and bar model completeness had a direct effect on bar model correctness. However, bar model completeness had only an indirect effect on overall solution correctness. A qual-itative analysis of the types of completeness and correctness errors that PSTs made when creating bar models yielded three categories of completeness errors and five categories of correctness errors. Most of these error types were general errors related to creating bar models for problems from any content domain, and the distribution of correct and incorrect overall solutions within these categories was approximately uniform. However, one error category, incorrectly representing a fractional relationship, was specific to the domain of fractions and impeded PSTs’ ability to generate a correct overall solution. This error reflects a key fraction concept, a misunderstanding of the unit whole, which has been well-documented in the literature as a conceptual difficulty for PSTs. Implications for research and teacher preparation are discussed.}, issn = {1386-4416} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_schrderdaniel_2025, title = {Exceedingly high levels of tetracycline resistance in Neisseria gonorrhoeae in eight WHO Enhanced Gonococcal Antimicrobial Surveillance Programme countries in three WHO regions, 2021-2024-doxycycline post-exposure prophylaxis will unlikely impact gonorrhoea burdens}, author = {Schröder, Daniel and Cherdtrakulkiat, Thitima and Doanh, Le Huu and Golparian, Daniel and Heng, Lon Say and Hoffman, Irving and Jacobsson, Susanne and Jamoralin, Manuel C. and Kakooza, Francis and Kittiyaowamarn, Rossaphorn and Kyambadde, Peter and Maseko, Venessa and Matoga, Mitch and Müller, Etienne and Nguyen, Thuy Thi Phan and Ouk, Vichea and Setiawaty, Vivi and Sia, Sonia B. and Sulaiman, Verawati and Virak, Mot and Thuy Van, Nguyen Thi and Wi, Teodora and Maatouk, Ismael and Unemo, Magnus}, year = {2025}, journal = {Journal of Antimicrobial Chemotherapy}, volume = {80}, number = {5}, pages = {1291--1295}, doi = {10.1093/jac/dkaf066}, url = {1946429}, language = {eng}, publisher = {Oxford University Press}, abstract = {OBJECTIVES: Doxycycline post-exposure prophylaxis (doxycycline-PEP) can reduce incident cases of syphilis, chlamydia and possibly gonorrhoea especially among men who have sex with men with recent bacterial sexually transmitted infections (STIs). Owing to potential implementation of doxycycline-PEP internationally, global tetracycline/doxycycline resistance data for contemporary Neisseria gonorrhoeae isolates has become imperative. We report tetracycline resistance data for gonococcal isolates (n = 2993) from eight WHO Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP) countries in three WHO regions in 2021-2024, i.e. to estimate potential impact of doxycycline-PEP on the incident gonorrhoea cases in these WHO EGASP countries.METHODS: WHO EGASP isolates cultured from men with urethral discharge in Cambodia (n = 482), Indonesia (n = 101), Malawi (n = 121), The Philippines (n = 843), South Africa (n = 597), Thailand (n = 250), Uganda (n = 350) and Vietnam (n = 249) in 2021-2024 were examined. MICs (mg/L) of tetracycline were determined using Etest.RESULTS: The tetracycline resistance (range) using the current EUCAST (MIC > 0.5 mg/L) and CLSI (MIC > 1 mg/L) clinical resistance breakpoints in the eight WHO EGASP countries was 92.2% (83.5%-99.6%) and 80.6% (66.3%-98.6%), respectively. Using a previous minocycline-PEP resistance breakpoint (MIC > 2 mg/L) and breakpoint for high-level plasmid (tetM)-mediated tetracycline resistance (MIC > 8 mg/L), the tetracycline resistance (range) was 77.3% (47.4%-98.6%) and 74.3% (31.3%-98.6%), respectively.CONCLUSIONS: The exceedingly high levels of gonococcal tetracycline resistance (independent of resistance breakpoint used) in the eight WHO EGASP countries elucidate that doxycycline-PEP will unlikely significantly reduce the gonorrhoea cases in these countries. Furthermore, doxycycline-PEP might rapidly select for additional gonococcal strains with tetracycline resistance (low- and high-level) and MDR/XDR strains, i.e. because these strains are mostly resistant to tetracycline.}, issn = {0305-7453} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tynikristiina_2025_1, title = {Existential dimensions of the lived experiences of transgender youths 13-16 years in a cisnormative Swedish context}, author = {Tyni, Kristiina and Wurm, Matilda and Bratt, Anna Sofia}, year = {2025}, journal = {International Journal of Transgender Health}, pages = {1--16}, doi = {10.1080/26895269.2024.2440864}, url = {1925438}, language = {eng}, publisher = {Taylor & Francis}, keywords = {existential; gender identity; lgbtq; qualitative research; teen}, abstract = {Background: Transgender and gender diverse (TGD) youth face existential challenges in navigating their genders in a cisnormative world that often misrecognizes or denies them.Aim: This qualitative study aimed to deepen the understanding of existential dimensions of the participants’ lived experiences related to gender, within a cisnormative context.Methods: A reflexive thematic analysis was conducted on the lived experiences of nine Swedish binary transgender youths, aged 13-16.Results: Two main themes were developed: 1) “Disorientation and existential challenges: navigating self-recognition in a non-inclusive world,” with subthemes Can I exist in the world’ and Can I exist in my body?; and 2) “Relational responsibility: emotional work to be recognized,”with subthemes Taking responsibility for my safety; Responsibility for others—facilitating recognition; and Reorientation and the power of recognition.Discussion: Drawing on Ahmed’s Queer Phenomenology and Honneth’s Theory of Recognition, the study highlighted how limited awareness or denial of gender diversity shaped participants’ struggles to orient themselves in a cisnormative society. Living authentically required significant emotional labor in navigating relationships, reflecting an ongoing process of coping and a deep need for emotional, communal, and legal recognition.Conclusion: By exploring the existential dimensions of participants’ lived experiences within cisnormativity, this study underscored the power of (mis-)recognition and the emotional laborTGD youth undertake to create livable spaces for authentic lives. A holistic understanding of their experiences can guide professionals, parents, and others in providing better support.}, issn = {2689-5269} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_tryggvasonsgeir_2025_1, title = {Existentiella miljö- och hållbarhetsfrågor i en instrumentaliserad skola}, author = {Tryggvason, Ásgeir and Mårdh, Andreas and Sund, Louise and Öhman, Johan}, year = {2025}, url = {2019782}, language = {swe}, keywords = {hållbar utveckling; miljöundervisning; miljö- och hållbarhetsutbildning; existentiella frågor; undervisning} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_chaillouthomas_2025, title = {Exogenous heating induces a more pronounced rise in prolactin concentration than exertional heating in young men, despite a closely matched body core temperature increase}, author = {Chaillou, Thomas and Hogg, Cameron and Treigyte, Viktorija and Juškevičiūtė, Ema and Eimantas, Nerijus and Brazaitis, Marius}, year = {2025}, journal = {Journal of Thermal Biology}, volume = {133}, doi = {10.1016/j.jtherbio.2025.104290}, url = {2005960}, language = {eng}, publisher = {Elsevier}, keywords = {exercise; heat stress; hot-water immersion; passive heating; skin temperature; thermoregulation}, abstract = {This study aimed to compare blood prolactin concentrations and thermal perceptions between exertional heating (Exer-H) and exogenous heating (Exo-H) eliciting a closely matched elevation of rectal temperature (Trec) but different changes in skin temperature (Tsk) in young active males. Fourteen participants were randomly exposed to Exer-H (ergocycle at 60 % VO2max at 30 °C) and Exo-H (hot-water immersion up to the waist, 43-44 °C). The heating phase ended when Trec (Peak) reached 39 °C, or was <39 °C but reached the volunteers' limit point of tolerance. The post-heating phase (passive sitting) ended when Trec decreased to 37.5 °C. Blood prolactin concentration and Tsk were assessed during the heating and post-heating phases, and thermal perceptions were determined during the heating phase. Peak Trec was slightly higher in Exo-H than Exer-H (39.00 ± 0.00 °C vs. 38.82 ± 0.27 °C; P = 0.028). The Δ changes in prolactin concentration and Tsk (especially Calf and Thigh) were larger in Exo-H during the heating and post-heating phases (P < 0.05). Sweating/shivering, thermal comfort, and thermal sensation scores did not differ between Exer-H and Exo-H during heating. Positive relationships were found between Δ changes in prolactin concentration and Δ changes in Tsk, with the best associations observed for Tsk Calf and Tsk Thigh in both phases. Thermal comfort/sensation correlated positively with Δ changes in prolactin concentration, while sweating/shivering correlated negatively with body mass loss (%). In conclusion, prolactin concentrations show a more pronounced increase during Exo-H compared to Exer-H, despite a closely matched elevation of Trec. This result may be explained by the large differences in Tsk of the lower limbs between the two heating conditions. Moreover, thermal perceptions are not differently affected during Exer-H and Exo-H. Our findings suggest that sweating sensation could partially reflect the hydration status, while thermal comfort and sensation may be partly connected to changes in prolactin concentrations.}, issn = {0306-4565} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_knudsenpeter_2025, title = {Expanding horizons – Reimagining 20th century Western classical music via improvisation}, author = {Knudsen, Peter}, year = {2025}, pages = {2--3}, url = {2010195}, language = {eng}, abstract = {This presentation is based on the PhD project “Expanding Horizons”, an artistic research project that looks at how musical works from 20th-century Western classical music can be reimagined for the purpose of integrating improvisation into the musical performance. Examples presented include music by Lili Boulanger and Toru Takemitsu reimagined for improvising musicians, based on two album releases:  All in Twilight (David Härenstam & Peter Knudsen, 2023) and Reimaginations (Peter Knudsen, 2024). Given that the works in question are conveyed through musical scores with a high degree of specificity, the role of the score is also examined, and how it can be reconfigured for the purpose of opening up the music via improvisation.  The presentation also addresses the interconnection between artistic work processes and a qualitative research methodology based on autoethnography and participant-observation. Throughout the project, various qualitative methods were used: - Audio journaling in combination with automatic speech-to-text transcription, particularly during the preparatory phases of the work. - Participant-observation during musical sessions with participating musicians, often followed by semi-structured interviews. - Focus group interviews in the form of listening sessions and panel discussions, sometimes carried out in the presence of an audience. - Semi-structured interviews with key respondents, particularly with musicians with experience in improvising over Western art music. The vast amount of data produced from these sessions was then analyzed using reflexive thematic analysis, following an approach by Braun and Clarke (2022) where patterns and themes are created through systematically engaging with the dataset. Challenges and possibilities with this methodological approach are also considered. } } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_knudsenpeter_2025_1, title = {Expanding horizons : ett improvisationsbaserat utforskande av 1900-talets konstmusik (lecture recital)}, author = {Knudsen, Peter}, year = {2025}, pages = {40--40}, url = {2010188}, language = {swe}, publisher = {Örebro universitet} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_carlbckmats_2025, title = {Experience accounting to improve strategic decision-making in a rural resort : application case report}, author = {Carlbäck, Mats and Demydyuk, Ganna V.}, year = {2025}, journal = {Journal of Global Hospitality and Tourism}, volume = {4}, number = {1}, pages = {89--95}, url = {1955042}, language = {eng}, publisher = {USF M3 Publishing}, keywords = {customer-perceived value; resource allocation; hospitality management; strategic decision making; customer satisfaction; customer-centric accountin}, abstract = {This report explores the application of Experience Accounting (EA) to enhance strategic decision making in a rural resort, focusing on improving profitability through customer-centric financial management. This study addresses the challenges faced by small- and medium-sized enterprises (SMEs) in the hospitality industry, particularly the lack of tailored information systems for effective decision-making. By integrating the Resource-Based View (RBV) and the stimulus-organism-response (S-O-R) paradigm, EA aligns cost accounting with customer-perceived value, optimizing resource allocation to enhance customer experience and willingness to pay. The case study of a rural upmarket resort demonstrates the practical implementation of EA, revealing insights into resource consumption and customer value across various service components. The findings highlight the inefficiencies in the current service provision and suggest strategic reallocations to improve customer satisfaction and profitability. The results indicate that reallocating resources to enhance service quality rather than infrastructure can lead to greater customer satisfaction and profitability. The adaptability of the EA framework across different hospitality segments underscores its potential for widespread application, offering a valuable tool for the continuous optimization of expenditures and prices based on real-time customer feedback.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jaenssonmaria_2025, title = {Experience of student nurse anesthetists´ learning in the operating room during the COVID-19 pandemic : a qualitative interview study}, author = {Jaensson, Maria and Hedlund, Jakob and Blomberg, Karin}, year = {2025}, journal = {Journal of Perianesthesia Nursing}, volume = {40}, number = {2}, pages = {294--299}, doi = {10.1016/j.jopan.2024.04.010}, url = {1854586}, language = {eng}, publisher = {Elsevier}, keywords = {clinical clerkship; covid-19; nurse anesthetist program; operating room; qualitative methods; interviews}, abstract = {Purpose: This study explores student nurse anesthetists' (SNAs) learning in the operating room during the coronavirus 2019 pandemic.Design: An explorative design with semistructured interviews was used.Methods: Thirteen former SNAs and 12 clinical supervisors (8 of whom were included in the final analysis) were recruited from 6 counties in Sweden. Participants were purposively recruited. Inclusion criterion for former SNAs was having completed the nurse anesthesia program in the fall of 2020 to spring 2022; and for nurse anesthetists, those who have experience in supervising SNAs. The interviews were analyzed with thematic analysis.Findings: The analysis identified one theme and five subthemes. The theme was that student learning was in focus despite an ongoing pandemic. Every learning situation contributed, and learning was triggered by the challenges. Both the SNAs and the supervisors exhibited resilience by accepting the situation and striving to do their absolute best in a nonoptimal learning environment. Over time, learning and supervision returned to normal.Conclusions: During the pandemic, learning was ongoing despite stress, fear, and other challenging factors. Students' learning appears to have been prioritized. The study highlights that nurse anesthetists and SNAs were resilient, resourceful, and able to find new ways to keep learning going. }, issn = {1089-9472} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_randelleva_2025, title = {Experienced parental support for parents with intellectual and developmental difficulties}, author = {Randell, Eva and Wennberg, Birgitta and Strandberg, Thomas and Holmefur, Marie and Forslund, Tommie}, year = {2025}, url = {1988313}, language = {eng}, abstract = {Parents with intellectual and developmental disabilities (IDDs) often need parenting support, but there are few evidence-based support programs adapted to these parents’ cognitive needs. Parenting Young Children (PYC) is a home-based parenting support program developed for parents with IDDs in Australia and has then been implemented in Sweden. PYC emphasizes individualized goals, breaking down complex skills into smaller steps, and collaborating with the parents. To investigate the usefulness and acceptability of PYC, it is of vital importance to explore how the intervention is perceived by the parents.The aim of the present study was to explore how PYC is perceived by Swedish parents with IDD, in need of adapted parenting support when there is a risk for neglect.Parents' experiences of PYC were explored shortly after completing PYC, using individual, semi-structured interviews that are audio-recorded and transcribed. Data were analysed using reflexive thematic analysis. In total, 15 parents (8 mothers, 7 fathers) have been interviewed. Participating parents have mild ID or other cognitive difficulties (e.g., ASD) and have children between 0-9 years of age.The parents experienced increased security in parenting, improvements in parenting skills, and strengthened self-confidence. PYC influenced parent-child relationships so that the child's needs were put in focus. The parents also emphasized that their parental competence developed in a trusting, participatory process in which it was important to feel included and treated positively. A prerequisite was that the PYC-social worker cooperates with the parent and is sensitive to the parent’s specific needs and wishes. According to the parents, the PYC-social worker should focus on the relationship between the parent and the PYC-social worker, and parents' knowledge and skills to increase the parent's competence. It was also of vital importance to include the needs of both the child and the parent.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_imhagenannika_2025, title = {Experiences of an internet-delivered treatment of obesity : A qualitative study}, author = {Imhagen, Annika and Jansson, Stefan P. O. and Söderqvist, Fredrik and Karlsson, Jan and Galavazi, Marije and Anderzen-Carlsson, Agneta}, year = {2025}, journal = {Internet Interventions}, volume = {42}, doi = {10.1016/j.invent.2025.100876}, url = {2009850}, language = {eng}, publisher = {Elsevier}, abstract = {Highlights•  Internet-delivered obesity treatment can help change lifestyle habits•  Expectations for weight loss were not met•  Life circumstances made it difficult to commit to treatment•  Internet-delivered treatment is not for everyone.}, issn = {2214-7829} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nilssonmariabirgitta_2025, title = {Experiences of Home-Based Participation in a Digitally Distributed Yoga Intervention in Breast Cancer Rehabilitation : Qualitative Content Analysis}, author = {Nilsson, Maria Birgitta and Arvidsson Lindvall, Mialinn and Fessé, Per Wilhelm Tage and Hellerstedt-Börjesson, Susanne and Ohlsson-Nevo, Emma and Duberg, Anna}, year = {2025}, journal = {Journal of Medical Internet Research}, volume = {27}, doi = {10.2196/75975}, url = {2015878}, language = {eng}, publisher = {JMIR Publications}, keywords = {breast cancer; cancer rehabilitation; cancer-related fatigue; ehealth; empowerment; mental health; self-care; telerehabilitation; yoga}, abstract = {BACKGROUND: Breast cancer is the most diagnosed cancer among women, with survivors often experiencing long-term symptoms such as cancer-related fatigue, which significantly impacts quality of life. Yoga has demonstrated potential in alleviating cancer-related fatigue and enhancing overall health and quality of life. Digital interventions are increasingly recognized as a feasible approach to cancer rehabilitation. However, digitally distributed home-based yoga interventions in breast cancer rehabilitation remain underexplored. More research in this area is essential to achieve a deeper understanding of participants' experiences.OBJECTIVE: This study aims to explore women's experiences of participating in a digitally distributed, home-based yoga intervention in breast cancer rehabilitation.METHODS: This qualitative study used an inductive content analysis approach. Semistructured interviews were conducted with 20 women who had undergone breast cancer surgery and participated in a 12-week digitally distributed, home-based yoga intervention as part of the randomized controlled multicenter trial Digital Yoga Intervention in Cancer Rehabilitation (DigiYoga CaRe). The intervention consisted of 2 home-based yoga sessions each week: 1 live-streamed group class led by an experienced yoga instructor and 1 prerecorded self-paced practice video. Interviews were conducted within 1 month of completing the intervention, using a semistructured guide with 12 open-ended questions covering physical and mental experiences, daily life impacts, and reflections on the digital format (live-streamed and prerecorded video). The interview transcripts were analyzed using conventional content analysis to identify subcategories and categories, providing insights into participants' experiences.RESULTS: The interviewees reported that the home-based yoga intervention helped them to actively manage their illness and treatment-related side effects, promoting mental recovery and relaxation, physical function and activity, and self-care practice and routines. They commented that it fostered resilience and empowerment through increased body awareness and by regaining trust in their bodies, self-confidence, and hope for recovery. It was described as a shift in focus toward progress and well-being, equipping them with new coping strategies for their daily lives. They perceived the telerehabilitation format as a safe and user-friendly rehabilitation option, providing support through manageable digital tools, and with minor technical issues that were subsequently resolved. They described feeling safe and supported in the digital environment, fostering a sense of community and individual focus. The accessibility of home-based participation facilitated adherence, making the intervention a valuable and inclusive rehabilitation option for breast cancer survivors, particularly for those experiencing fatigue, time constraints, or challenges related to traveling.CONCLUSIONS: The digitally distributed home-based yoga intervention was experienced as an effective and accessible tool for breast cancer rehabilitation, promoting overall well-being. For these participants, it fostered resilience, empowerment, and a sense of community; this highlights its potential as a user-friendly rehabilitation option that could be integrated into cancer care to support recovery and address various patient needs.TRIAL REGISTRATION: ClinicalTrials.gov NCT04812652; https://clinicaltrials.gov/study/NCT04812652. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.1136/bmjopen-2022-065939.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_svedjebrantmaria_2025, title = {Experiences of participation in cardiorespiratory training among people with post-stroke fatigue : a qualitative study}, author = {Svedjebrant, Maria and Bråndal, Anna and Nilsagård, Ylva}, year = {2025}, journal = {Journal of Rehabilitation Medicine}, volume = {57}, doi = {10.2340/jrm.v57.42282}, url = {1953124}, language = {eng}, publisher = {Foundation of Rehabilitation Medicine}, keywords = {cerebrovascular disorders; post-stroke fatigue; cardiorespiratory training; qualitative study}, abstract = {OBJECTIVE: To explore the experiences of 8-week thrice-weekly supervised intense cardiorespiratory interval training at home in people with post-stroke fatigue. DESIGN: Qualitative, using semi-structured individual interviews. METHODS: Eleven people with post-stroke fatigue were recruited from a study investigating the effects of supervised intense cardiorespiratory interval training. The interviews were conducted 1-2 weeks after the intervention period and analysed inductively with qualitative content analysis.RESULTS: The theme "Supervised cardiorespiratory interval training at home was perceived as feasible and safe, reducing fatigue and contributing to enhanced self-efficacy in both exercise and everyday life" was based on 4 main categories: "Experiences of performing the intervention and testing, "Perceived impact of the intervention on fatigue", "Perceived impact of the intervention on self-efficacy", and "The reinforcing experiences of exercise transfer to everyday life". The informants reported that participating in the intervention made them feel physically and mentally stronger and no longer restricted by a lack of confidence in performing activities that increased their heart rate. CONCLUSIONS: Participating in supervised intense cardiorespiratory interval training provided a model on how to train, which was transferable to other contexts in everyday life. The training improved exercise self-efficacy and gave the informants the confidence to challenge themselves in everyday life.}, issn = {1650-1977} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lidskogrolf_2025, title = {Expert Advice and Global Environmental Governance : Institutional and Epistemic Challenges for Assessment Bodies}, author = {Lidskog, Rolf}, year = {2025}, journal = {Sustainability}, volume = {17}, number = {17}, pages = {1--16}, doi = {10.3390/su17177876}, url = {1994460}, language = {eng}, publisher = {MDPI}, keywords = {climate change; expertise; global environmental assessment (gea); global environmental challenges; ipcc; interview study; science-policy relations; science-policy interface}, abstract = {The global community remains significantly off track in achieving the United Nations Sustainable Development Goals (SDGs), prompting calls for not only stronger political commitments but also more effective and credible expert guidance. This paper contributes to this discourse by examining a critical form of global environmental expertise: the conductof global environmental assessments. Such expertise has become a foundational component of the institutional architecture underpinning global sustainability governance. Focusing on the Intergovernmental Panel on Climate Change (IPCC), one of the most prominent and widely recognized international expert bodies, this study examines the challenges that researchers face when synthesizing research findings and making them policyrelevant within the IPCC’s assessment work. The empirical material consists of an interview study (N = 18) conducted with experts involved in the IPCC, from its first assessment (1990) to the most recent one (2023). The data were analyzed thematically using NVivo.The analysis reveals four key internal challenges that the IPCC must address to enhanceits advisory capacity: epistemic hierarchies, leadership and management dynamics, the complexities of formulating recommendations, and inequities in recognition and reward systems. By identifying and analyzing these challenges, the paper contributes to ongoing discussions about the IPCC’s future development and offers broader insights into the evolving role of scientific expertise in global environmental governance.}, file = {https://oru.diva-portal.org/smash/get/diva2:1994460/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johnstoneleanne_2025, title = {Explaining knowledge use and development beyond business renewal nets}, author = {Johnstone, Leanne and Lagin, Madelen and Öberg, Christina}, year = {2025}, journal = {European Journal of Marketing}, volume = {59}, number = {13}, pages = {272--302}, doi = {10.1108/EJM-05-2023-0404}, url = {1992119}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {business renewal net; knowledge perspective; regional development; strategic net; sustainability}, abstract = {PurposeIn times that challenge businesses, requiring them to make strategic and operational changes due to downturns in the economy or environmental requirements, governments may initiate business renewal nets (BRNs) to foster development among firms. Knowledge is central to such initiatives. Drawing on a knowledge perspective, this paper aims to explain how the knowledge created and exchanged in BRNs is used and developed by the involved firms beyond the nets' temporal and spatial boundaries.Design/methodology/approachA multiple case study approach of two BRNs in Sweden was adopted, drawing on interviews, observations, documents and informal meetings with net participants and governmental bodies.FindingsThe paper finds that knowledge use and development beyond the net are conditional on the (1) within-net knowledge arrangement; (2) relative knowledge distance between the nets' participating parties; (3) parties' engagement in the cause; and (4) involvement of these parties in within-net knowledge exchange and creation.Research limitations/implicationsThe paper helps explain the characteristics of knowledge exchange and creation that contribute to knowledge use and development beyond nets. It theorises four dimensions to explain whether knowledge is used or developed beyond the net. These are knowledge arrangement, knowledge distance, knowledge engagement and knowledge contingency.Practical implicationsThe paper provides strategic advice for those establishing BRNs to ensure that aims are met.Originality/valueAdopting a knowledge perspective in the interorganisational context, the paper contributes to past research on net initiatives by linking beyond-net knowledge use and development with the within-net circumstances, offering propositions for BRN success.}, issn = {0309-0566} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_granathannika_2025_1, title = {Exploration of health-related quality of life, anxiety, and depression in antineutrophil cytoplasmic antibody-associated vasculitis}, author = {Granath, Annika and Brolin, Sara and Dahlberg, Karuna and Gunnarsson, Iva and Welin, Elisabet and Pettersson, Susanne}, year = {2025}, journal = {Rheumatology}, volume = {64}, number = {12}, pages = {6233--6240}, doi = {10.1093/rheumatology/keaf417}, url = {1990087}, language = {eng}, publisher = {Oxford University Press}, keywords = {anca associated vasculitis; anxiety; cluster analysis; depression; fatigue; health-related quality of life; patient perspective}, abstract = {OBJECTIVES: To explore health-related quality of life (HRQoL), anxiety, depression and fatigue among persons with ANCA-associated vasculitis (AAV).METHODS: In this cross-sectional study, patients were assessed with the EuroQoL five-dimension three-level questionnaire (EQ-5D-3L) and visual analogue scale (EQ-VAS), the Hospital Anxiety and Depression Score (HADS), and the Multidimensional Assessment of Fatigue questionnaire (MAF).RESULTS: HRQoL measured with EQ-VAS was higher in younger patients, those with inactive disease (BVAS = 0), and those with long disease duration (≥3 years), while EQ-5D-3L only varied with disease activity. Women, patients with active disease, and patients with shorter disease duration reported more anxiety, and younger persons with active disease and short disease duration reported more fatigue. In the total group, disease activity and disease duration were both associated with HRQoL, anxiety, depression and fatigue. Four clusters based on EQ-5D, EQ-5D index, and HADS were identified, containing patients with various levels of HRQoL and psychological distress across the disease course.CONCLUSION: In patients with AAV, HRQoL, anxiety, depression, and fatigue, is persistent but varies depending on disease activity, disease duration, gender, and age. Associations between disease activity and duration and HRQOL, anxiety, depression, and fatigue were present in all patients. Four clusters revealed the ongoing influence of AAV, emphasizing the continuous need for multiprofessional support during the disease course. In this study, EQ-VAS was better able than EQ-5D-index to effectively distinguish subgroups with different levels of HRQoL.}, issn = {1462-0324}, file = {https://oru.diva-portal.org/smash/get/diva2:1990087/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssonfredrik_2025, title = {Exploring Classification Consistency of Natural Language Requirements Using GPT-4o}, author = {Karlsson, Fredrik and Chatzipetrou, Panagiota and Gao, Shang and Havstorm, Tanja Elina}, year = {2025}, volume = {539}, pages = {44--50}, doi = {10.1007/978-3-031-85849-9_4}, url = {1959807}, language = {eng}, publisher = {Springer}, keywords = {requirements; classification; large language model; zero-shot learning}, abstract = {Classifying natural language requirements (NLRs) is challenging, especially with large volumes. Research shows that Large Language Models can assist by categorizing NLRs into functional requirements (FR) and non-functional requirements (NFRs). However, Generative Pretrained Transformer (GPT) models are not typically favored for this task due to concerns about consistency. This paper investigates the consistency when a GPT model classifies NLRs into FRs and NFRs using a zero-shot learning approach. Results show that ChatGPT-4o performs better for FRs, a temperature parameter set to 1 yields the highest consistency, while NFR classification improves with higher temperatures.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_brozovicdanilo_2025, title = {Exploring futures through science fiction : A scenario-based PESTLE analysis of award-winning SF novels}, author = {Brozovic, Danilo and Carlborg, Per and Hasche, Nina}, year = {2025}, journal = {Futures: The journal of policy, planning and futures studies}, volume = {172}, doi = {10.1016/j.futures.2025.103647}, url = {1986220}, language = {eng}, publisher = {Elsevier}, keywords = {science fiction; sf; future scenarios; scenario building; pestle}, abstract = {This article extends the exploration of potential futures as envisioned in science fiction (SF) literature by analyzing how emerging trends are portrayed through a structured analytical framework. Specifically, it examines award-winning SF novels, focusing on political, economic, social, technological, legal, and environmental (PESTLE) dimensions as imagined by prominent authors within the genre. Thus, the purpose of the article is to provide an overview of emerging trends and tendencies within imagined futures as depicted in acclaimed SF literature, framed through the lens of PESTLE analysis. To this end, four future scenarios were extrapolated from a selection of 42 novels that have either won or been nominated for major SF awards-the Nebula and the Hugo. These scenarios are: Solar System Expansion, Cyber High-Tech Future, Post-Contraction Society, and Dystopian Future. Each scenario is assessed according to its political, economic, social, technological, legal, and environmental characteristics.}, issn = {0016-3287} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_herringmatthew_2025, title = {Exploring NLRP3-related phenotypic fingerprints in human macrophages using Cell Painting assay}, author = {Herring, Matthew and Särndahl, Eva and Kotlyar, Oleksandr and Scherbak, Nikolai and Engwall, Magnus and Karlsson, Roger and Ejdebäck, Mikael and Persson, Alexander and Alijagic, Andi}, year = {2025}, journal = {iScience}, volume = {28}, number = {3}, doi = {10.1016/j.isci.2025.111961}, url = {1936375}, language = {eng}, publisher = {Cell Press}, keywords = {inflammasome; high-throughput imaging; cytokine profiling; thp-1 cells; morphological features}, abstract = {Existing research has proven difficult to understand the interplay between upstream signalinge vents during NLRP3 inflammasome activation. Additionally, events downstream of inflammasome complex formation such as cytokine release and pyroptosis can exhibit variation, further complicating matters. Cell Painting has emerged as a prominent tool for unbiased evaluation of the effect of perturbations on cell morphological phenotypes. Using this technique, phenotypic fingerprints can be generated that reveal connections between phenotypes and possible modes of action. To the best of our knowledge, this was the first study that utilized Cell Painting on human THP-1 macrophages to generate phenotypic fingerprints in response to different endogenous and exogenous NLRP3 inflammasome triggers, and to identify phenotypic features specific to NLRP3 inflammasome complex formation. Our results demonstrated that not only can Cell Painting generate morphological fingerprints that are NLRP3 trigger-specific, but it can identify cellular fingerprints associated with NLRP3 inflammasome activation.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindalexandra_2025, title = {Exploring ocular fundus morphology in relation to growth in adolescents born moderate-to-late preterm}, author = {Lind, Alexandra and Ali, Sara and Ovik, Titus and Popovic, Zoran and Aring, Eva and Dahlgren, Jovanna and Andersson Grönlund, Marita}, year = {2025}, journal = {Acta Ophthalmologica}, doi = {10.1111/aos.70011}, url = {2003810}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {adolescence; insulin‐like growth factor‐i; macular retinal thickness; moderate‐to‐late preterm; optical coherence tomography and retinal nerve fibre layer}, abstract = {PURPOSE: To study ocular fundus morphology and its relation to growth in adolescents born moderate-to-late preterm (MLP) and full term.METHODS: This prospective and population-based cohort study included 50 MLP adolescents (26 girls, mean age 16.5 years) and 50 full-term controls (30 girls, mean age 16.7 years). Optical coherence tomography measurements were studied in relation to gestational age, auxological data, insulin-like growth factor-I (IGF-I) and IGF-binding protein 3 (IGFBP-3).RESULTS: The MLP group showed an increased central macular retinal thickness (MRT) compared with controls in right eye (RE) (249.7 ± 21.0 vs. 239.9 ± 16.4 μm, p = 0.019). Moreover, the MLP group showed a thinner total peripapillary retinal nerve fibre layer (ppRNFL) thickness in RE (104.3 ± 8.5 vs. 109.1 ± 8.3, p = 0.0011). Nasal ppRNFL thickness was thinner in both RE (79.4 ± 13.2 vs. 85.0 ± 10.8, p = 0.0012) and left eye (LE) (77.0 ± 13.8 vs. 81.7 ± 13.4, p = 0.025) compared with controls. A weak association between total ppRNFL thickness and IGF-I levels was found (RE, r = 0.28, p = 0.032; LE, r = 0.27, p = 0.048), as well as between central MRT and a ratio between IGF-I and IGFBP-3 levels (RE, r = 0.30, p = 0.022). Additionally, there was a correlation between optic cup/disc area ratio and birth weight (RE: r = -0.44, p = 0.0006; LE: r = -0.30, p = 0.026).CONCLUSION: The present study suggests that growth and MLP birth may impact ocular fundus morphology. The MLP adolescents were shown to have thinner ppRNFL thickness and greater MRT, compared with full-term controls. Furthermore, a weak association between these structures and growth factors was found. In addition, the current study proposes that birth weight may impact optic disc parameters.}, issn = {1755-375X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bsjsara_2025, title = {Exploring sense of coherence (SOC) in relation to working conditions for employees with hearing loss}, author = {Båsjö, Sara and Gustafsson, Johanna and Granberg, Sarah}, year = {2025}, journal = {Work: A journal of Prevention, Assessment and rehabilitation}, volume = {82}, number = {3}, pages = {784--797}, doi = {10.1177/10519815251349523}, url = {1975345}, language = {eng}, publisher = {Sage Publications}, keywords = {hearing loss; occupational health; salutogenesis; sense of coherence; working conditions; workplace}, abstract = {Background People with hearing loss (HL) report several challenging situations in working life (WL). HL can negatively affect, e.g., the ability to communicate, creating barriers and difficulties in WL. However, there is a lack of studies that investigates salutary aspects in relation to working conditions for the target group. Sense of Coherence (SOC) is a salutary concept widely used when investigating aspects in WL but is less explored in relation to HL.Objective To explore the concept of Sense of Coherence (SOC) in relation to working conditions for employees with HL.Methods An observational study with a cross-sectional design including people with HL in working age using hearing aids (HAs) or cochlear implants (CIs). Comparisons were made between participants "in work" and participants on "HL-related sick leave".Results The "in work" group reported a higher SOC compared to the "HL-related sick leave" group. The analysis showed significant differences between the two groups in all three dimensions of SOC with the "in work" group being better off in almost all investigated variables.Conclusion SOC is a valuable concept for investigating working conditions for employees with HL. The results indicate that to increase the possibility of salutary working conditions, it is necessary to focus on consequences of HL, such as the need for recovery, autonomy and support. Addressing these aspects increases employees' comprehension of and ability to manage the work situation and their sense of meaningfulness, which may act as a buffer against work-related stress and reduce the risk of sick leave.}, issn = {1051-9815} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sandvollragnhild_2025, title = {Exploring the complexity in academic development through the lens of signature pedagogy}, author = {Sandvoll, Ragnhild and Bergh, Andreas and Solbrekke, Tone Dyrdal}, year = {2025}, journal = {Scandinavian Journal of Educational Research}, doi = {10.1080/00313831.2025.2558724}, url = {2001517}, language = {eng}, publisher = {Routledge}, keywords = {academic development; signature pedagogy; teaching quality; epistemology; collaborating across disciplines}, abstract = {In recent decades, improving teaching quality has been a priority on the political agenda, and the role and responsibilities of academic developers (ADs) has expanded from running courses for individual teachers to engaging in strategic work. Utilising Shulman's concept of signature pedagogy, this article contributes to the literature by scrutinising the practice of an AD's collaboration with dental educators to improve their practice of suitability assessment. This case study employs qualitative, multi-method data analysed abductively and theory driven. It explores the AD's efforts to challenge entrenched teaching practices, enrich teachers' pedagogical vocabulary, and make tacit knowledge explicit. The results highlight the benefits of academic development, emphasising sensitivity and curiosity towards the discipline. However, the study identifies missed opportunities to explore epistemological assumptions in teaching. The findings suggest that deeper engagement with signature pedagogy structures could foster critical examination and adaptation of teaching practices, ultimately enhancing both societal and individual development.}, issn = {0031-3831}, file = {https://oru.diva-portal.org/smash/get/diva2:2001517/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_engstrmingemar_2025, title = {Explosive Increase in Diagnosis and Treatment of ADHD in Sweden May Be Related to Private Health Providers Offering Fast-Track, Guaranteed Diagnoses}, author = {Engström, Ingemar}, year = {2025}, journal = {Acta Paediatrica}, volume = {114}, number = {9}, pages = {2095--2097}, doi = {10.1111/apa.70129}, url = {1957650}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, issn = {0803-5253} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ulvskoge_2025, title = {Expression of PD-L1, TIGIT, and CD155, and Human Papillomavirus Status in Patients with Advanced Penile Cancer}, author = {Ulvskog, E. and Kirrander, Peter and Persson, Erik K. and Lillsunde-Larsson, Gabriella and Dorofte, Luiza and Franceschini, Tania and Fiorentino, Michelangelo and Davidsson, Sabina}, year = {2025}, journal = {European Urology Open Science}, volume = {79}, pages = {102--110}, doi = {10.1016/j.euros.2025.07.012}, url = {1991583}, language = {eng}, publisher = {Elsevier}, keywords = {cd155; chemotherapy; human papillomavirus; pd-l1; penile cancer; radiotherapy; tigit; tumor microenvironment}, abstract = {BACKGROUND AND OBJECTIVE: To improve treatment for patients with penile cancer, there is a need for prognostic and treatment predictive biomarkers. The objective of this study was to examine the expression of checkpoint proteins (programmed cell death ligand 1 [PD-L1], T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain [TIGIT], and cluster of differentiation 155 [CD155]) and human papillomavirus (HPV) status in primary tumors of penile cancer patients with indication for perioperative oncological treatment. As a secondary aim, we evaluated the associations between these biomarkers and penile cancer-specific survival.METHODS: Fifty-two patients who underwent surgical treatment during 2009-2018 were included. HPV status was determined by polymerase chain reaction, and tissue microarray sections from primary tumors were subjected to immunohistochemistry to evaluate the expression of PD-L1, TIGIT, and CD155.KEY FINDINGS AND LIMITATIONS: PD-L1, TIGIT, and CD155 were expressed widely. Specifically, 75% of patients had PD-L1-positive tumors, 80% had TIGIT-positive tumors, and 98% had CD155-positive tumors. Additionally, 47% of patients had HPV-positive tumors. Patients with HPV-positive tumors had better survival than those with HPV-negative tumors. Patients with indication for perioperative oncological therapy who received such treatment and whose tumors exhibited low PD-L1 expression demonstrated better survival than those with higher PD-L1 expression levels. The main limitations of this study include the small number of patients, retrospective design, and use of tissue microarrays rather than whole tissue sections.CONCLUSIONS AND CLINICAL IMPLICATIONS: We found high expressions of the investigated checkpoint proteins, suggesting an immunosuppressed tumor microenvironment in patients with advanced penile cancer. These findings imply that checkpoint proteins could serve as prognostic and treatment predictive biomarkers. Patients with HPV-positive tumors had better prognosis.PATIENT SUMMARY: In this report, we investigated tumor tissue from patients with penile cancer and identified a high prevalence of proteins that play an important role in the immune system's defense against cancer. The findings suggest that these proteins can be important in understanding and developing treatments for patients with lymph node metastasized penile cancer.}, issn = {2666-1691} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lendaroeva_2025, title = {Extended reality used in the treatment of phantom limb pain : a multicenter, double-blind, randomized controlled trial}, author = {Lendaro, Eva and Van der Sluis, Corry K. and Hermansson, Liselotte and Bunketorp-Käll, Lina and Burger, Helena and Keesom, Els and Widehammar, Cathrine and Munoz-Novoa, Maria and McGuire, Brian E. and Reilly, Paul O ' and Earley, Eric J. and Iqbal, Sonam and Kristoffersen, Morten B. and Stockselius, Anita and Gudmundson, Lena and Hill, Wendy and Diers, Martin and Turner, Kristi L. and Weiss, Thomas and Ortiz-Catalan, Max}, year = {2025}, journal = {Pain}, volume = {166}, number = {3}, pages = {571--586}, doi = {10.1097/j.pain.0000000000003384}, url = {1896381}, language = {eng}, publisher = {Wolters Kluwer}, keywords = {pain; phantom limb; amputation; virtual reality exposure therapy; augmented reality; rehabilitation; pain management}, abstract = {Phantom limb pain (PLP) represents a significant challenge after amputation. This study investigated the use of phantom motor execution (PME) and phantom motor imagery (PMI) facilitated by extended reality (XR) for the treatment of PLP. Both treatments used XR, but PME involved overt execution of phantom movements, relying on the decoding of motor intent using machine learning to enable real-time control in XR. In contrast, PMI involved mental rehearsal of phantom movements guided by XR. The study hypothesized that PME would be superior to PMI. A multicenter, double-blind, randomized controlled trial was conducted in 9 outpatient clinics across 7 countries. Eighty-one participants with PLP were randomly assigned to PME or PMI training. The primary outcome was the change in PLP, measured by the Pain Rating Index, from baseline to treatment cessation. Secondary outcomes included various aspects related to PLP, such as the rate of clinically meaningful reduction in pain (CMRP; >50% pain decrease). No evidence was found for superiority of overt execution (PME) over imagery (PMI) using XR. PLP decreased by 64.5% and 68.2% in PME and PMI groups, respectively. Thirty-seven PME participants (71%) and 19 PMI participants (68%) experienced CMRP. Positive changes were recorded in all other outcomes, without group differences. Pain reduction for PME was larger than previously reported. Despite our initial hypothesis not being confirmed, PME and PMI, aided by XR, are likely to offer meaningful PLP relief to most patients. These findings merit consideration of these therapies as viable treatment options and alternatives to pharmacological treatments.}, issn = {0304-3959} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrkjonas_2025, title = {Extending the Lund-Malmö creatinine-based GFR equation to cystatin C - validation results from the European Kidney Function Consortium (EKFC) cohort of children and adults}, author = {Björk, Jonas and Nyman, Ulf and Berg, Ulla and Bökenkamp, Arend and Cavalier, Etienne and Ebert, Natalie and Eriksen, Björn O. and Derain Dubourg, Laurence and Goffin, Karolien and Grubb, Anders and Hansson, Magnus and Larsson, Anders and Lemoine, Sandrine and Littmann, Karin and Mariat, Christophe and Melsom, Toralf and Schaeffner, Elke and Sundin, Per-Ola and Åsling-Monemi, Kajsa and Delanaye, Pierre and Pottel, Hans}, year = {2025}, journal = {Scandinavian Journal of Clinical and Laboratory Investigation}, volume = {84}, number = {7-8}, pages = {577--583}, doi = {10.1080/00365513.2024.2441280}, url = {1926038}, language = {eng}, publisher = {Taylor & Francis}, keywords = {glomerular filtration rate; chronic kidney disease; creatinine; cystatin c; kidney function tests}, abstract = {The aim of the present study was to extend the creatinine-based Lund-Malmö GFR equation for use with rescaled cystatin C (r-LMRCys) and validate it against measured GFR (mGFR) in the EKFC cystatin C cohort of children (n = 2,293) and adults (n = 7,727). Rescaling was obtained by dividing each biomarker by a Q-value, representing the population-specific median biomarker level among healthy individuals. Validation included median bias/precision/accuracy (percent estimates within ±30% of mGFR, P30). Performance was compared with the EKFC-equation (EKFCCys), the CAPA cystatin C equation, the corresponding equations based on rescaled creatinine (r-LMRCr and EKFCCr) and the arithmetic mean of r-LMRCr and CAPA (r-LMRCr+CAPA), r-LMRCr and r-LMRCys (r-LMRMean), and EKFCCr and EKFCCys (EKFCMean). The overall P30 of r-LMRCys in adults was 86.2% (95% CI 85.4%-86.9%), which was 6.6 percentage points (pp; 95% CI 5.8-7.4 pp) higher than for CAPA and similar to r-LMRCr (P30 87.4%, 95% CI 86.6%-88.1%). r-LMRCys and EKFCCys exhibited similar performance both overall and across subgroups of age, sex, GFR and BMI and in children. All three arithmetic mean equations had similar P30-accuracy and generally performed better than the corresponding single-marker equations. Our results show that the Lund-Malmö GFR equation can be adapted for use with rescaled cystatin C with performance that is similar to the best-performing equations based on rescaled creatinine. The generality of the applied biomarker rescaling principle implies that the future demand for population- and biomarker-specific GFR estimating equations can be expected to decrease substantially.}, issn = {0036-5513} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_brjessonmaria_2025, title = {External marginal costs for road accidents}, author = {Börjesson, Maria and Isacsson, Gunnar and Liss, Viktoria}, year = {2025}, journal = {Applied Economics}, doi = {10.1080/00036846.2025.2564463}, url = {2006800}, language = {eng}, publisher = {Routledge}, keywords = {marginal external costs; road accidents; risk elasticities; accident externalities; degree of risk internalization; r41; r42; r12}, abstract = {This article estimates the external marginal costs of traffic accidents for light and heavy vehicles. We use microdata covering the Swedish national road network from 2004 to 2012. We estimate the risk elasticities for heavy and light vehicles by applying a set of count data models that explain how the number of fatalities, and of severely and slightly injured individuals, changes in response to changes in traffic flows. We analyse the impact of observed and unobserved heterogeneity by applying a range of different model specifications. The weighted average of the external marginal costs for light and heavy vehicles is computed for the full road network, taking into account the degree of risk internalization by vehicle type. The preferred model yields an external marginal cost of 0.28 <euro> cents per vehicle-kilometre (vkm) for light vehicles, and this result is robust across specifications. The estimates for heavy vehicles are more sensitive to the model specification; including or excluding traffic flows of light vehicles has a substantial effect. Our preferred estimate for the external marginal cost of heavy vehicles is 2.36 <euro> cents per vkm. We find negative risk elasticities for both light and heavy vehicles.}, issn = {0003-6846} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wangqi_2025, title = {Extractable Organofluorine Mass Balance Analysis of Aqueous Film-Forming Foam-Impacted Soils : Sample Pretreatment and a Combination of Target Analysis and Suspect Screening}, author = {Wang, Qi and van Hees, Patrick and Karlsson, Patrik and Jiao, Enmiao and Filipovic, Marko and Lam, Paul K. S. and Yeung, Leo W. Y.}, year = {2025}, journal = {Environmental Science and Technology}, volume = {59}, number = {15}, pages = {7624--7633}, doi = {10.1021/acs.est.4c11909}, url = {1950590}, language = {eng}, publisher = {American Chemical Society (ACS)}, keywords = {ftab; pfhxs; pfos; enhanced extraction; source zones; suspect screening; unknown organofluorine; zwitterionic and anionic pfas}, abstract = {The application of aqueous film-forming foams (AFFFs) has caused considerable per- and polyfluoroalkyl substances (PFAS) pollution in the environment. Soil serves as a long-term source of PFAS for the adjacent groundwater and surface water, but the lack of extractable organofluorine (EOF) mass balance data in the AFFF-impacted soils may lead to an underestimation of PFAS contamination. This study analyzed ten surface soil samples from three AFFF-impacted sites in Sweden, using alkaline extraction followed by acidic extraction. The alkaline and acidic fractions were subjected to further cleanup and analyzed separately for target, suspect screening, and EOF analysis to evaluate the extraction efficiencies of different PFAS in the soil samples and reveal PFAS remaining unknown in the AFFF-impacted soils. Total target PFAS concentrations ranged from 33.0 to 2.40 × 104 ng/g dry weight. Thirty-six PFAS were identified using suspect screening. Considerable amounts of zwitterionic and cationic PFAS (up to 58%) were identified in the acidic extraction fraction, while >95% of anionic PFAS were found in the alkaline extraction fraction. EOF mass balance analysis was conducted on AFFF-impacted soils for the first time. The high proportion of unexplained organofluorine (up to 65%) indicated the necessity for future investigation of the unknown PFAS in AFFF-impacted soils to comprehensively understand their fate and risk.}, issn = {0013-936X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ballesterdolzpablo_2025, title = {Eye diseases in chronic kidney disease : A nationwide longitudinal case-control study in Sweden}, author = {Ballester Dolz, Pablo and Ålander, Karin and Smedberg, Petra and Vihlborg, Per and Bryngelsson, Ing-Liss and Westerlund, Jessica and Makdoumi, Karim}, year = {2025}, journal = {Clinical and Experimental Ophthalmology}, volume = {53}, number = {2}, pages = {209--217}, doi = {10.1111/ceo.14464}, url = {1914064}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {cataract; chronic kidney disease; eye disease; glaucoma; macular degeneration}, abstract = {BACKGROUND: Chronic kidney disease (CKD) is a growing health issue that is becoming more prevalent globally, increasing financial cost on healthcare systems. The purpose of this study is to investigate the incidence of eye diseases in patients diagnosed with CKD in Sweden and to evaluate which eye diseases are most likely to develop.METHODS: A longitudinal population-based retrospective case-control study was conducted including all individuals diagnosed with chronic kidney disease during the time period 2001-2019. A total of 19 455 cases and 38 890 controls were included. For each case, two controls were matched with the same sex, age, and county of residence.RESULTS: CKD patients had a significantly higher risk of contracting any eye disease compared to individuals without kidney disease HR 1.73 (CI 1.67-1.79), with an elevated risk for all blocks of diagnoses except for glaucoma HR 0.95 (CI 0.85-1.06). However, this condition developed earlier in cases than in controls. Subanalyses showed an increased risk for chronic eye disease patients to develop cataract HR 1.70 (CI 1.63-1.78), other retinal disorders HR 1.86 (CI 1.72-2.02), and retinal vascular occlusions HR 2.08 (CI 1.73-2.51). In general, diagnosis of an eye disease occurred earlier in cases than controls.CONCLUSIONS: The results from this study suggest that CKD patients have an increased risk to develop eye disease. Ocular disease seems to develop considerably earlier in CKD, even without staging the severity of the disease, with particularly high risk of developing retinal diseases and cataracts. Screening for eye disease in CKD should be considered.}, issn = {1442-6404} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ballesterdolzpablo_2025_1, title = {Eye Diseases in Chronic Kidney Disease : A Nationwide Longitudinal Case-Control Study in Sweden: Response}, author = {Ballester Dolz, Pablo and Vihlborg, Per and Bryngelsson, Ing-Liss and Makdoumi, Karim}, year = {2025}, journal = {Clinical and Experimental Ophthalmology}, volume = {53}, number = {5}, pages = {572--573}, doi = {10.1111/ceo.14505}, url = {1936028}, language = {eng}, publisher = {John Wiley & Sons}, issn = {1442-6404} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_schindlermaike_2025, title = {Eye-tracking research in mathematics and statistics education : recent developments and future trends. A systematic literature review}, author = {Schindler, Maike and Simon, Anna L. and Baumanns, Lukas and Lilienthal, Achim J.}, year = {2025}, journal = {ZDM - the International Journal on Mathematics Education}, volume = {57}, pages = {727--743}, doi = {10.1007/s11858-025-01699-8}, url = {1965730}, language = {eng}, publisher = {Springer}, abstract = {Eye tracking is gaining significance in mathematics education research at a tremendous speed. For the discipline to grow, it is essential to monitor, structure, and synthesize the research in this rapidly evolving field, which calls for a systematic literature review. However, a comprehensive and systematic review does not exist for the research for the past five years. This is a profound gap considering the dynamics of the field, which is fueled by technological advancements in hard- and software and the increasing usability and availability of eye-tracking systems. The aim of this paper is to provide a comprehensive and systematic literature review on eye-tracking research in mathematics and statistics education published in the past five years. Using a systematic database search, we identified and reviewed 116 eye-tracking studies published between 2019 and the first quarter of 2024. We found that the studies addressed a wide range of topics in all relevant curriculum content areas as well as a multitude of phenomena, including teacher-student interaction and digital learning. Interestingly, the studies increasingly involved school students, partially in authentic classroom settings. We also found that the majority of the papers referred to a theoretical framework or made assumptions about the (domain-specific) interpretation of eye movements explicit. As a further important trend, probably still in its infancy, we observed the use of AI techniques for data analysis purposes, which allows for qualitative insights despite bigger numbers of participants. Our paper provides an overview and detailed insights into trends, of which many have not been visible in earlier review studies.}, issn = {1863-9690} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_amourilayan_2025_1, title = {Facilitating belonging and integration : Exploring the PIA Youth Program’s role in social and emotional development among newly arrived youth}, author = {Amouri, Layan and Amouri, Hasnaa and Altebo Nyathi, Sandra and Özdemir, Metin}, year = {2025}, url = {2002353}, language = {eng}, abstract = {Background: Adolescence is a period of identity development and relational growth. For newly arrived youth, this process is complicated by the overlapping challenges of migration, language learning, and psychosocial adjustment. While many interventions for this group focus on clinical or academic outcomes, fewer address everyday experiences that shape social belonging and emotional wellbeing. The PIA Youth Program responds to this gap as a universal, school-based, dialogue-driven intervention designed to support integration through experience sharing,reflection, and positive reinforcement.Method: This presentation examines 19 semi-structured qualitative interviews with newly arrived adolescents (aged 14–16) who participated in the PIA Program, exploring their experiences of its impact on their social, emotional, and communicative development.Results: Using thematic analysis of in-depth interviews, key themes were identified as Language and communication skill development, Development of behavior, Emotional and social skills and Importance of leadership. Youth described sessions as safe and enjoyable spaces where they could speak without fear of judgment, reflect on identity and social norms, and enhance confidence. Participants emphasized that relatable texts, meaningful discussions, and a supportive facilitator helped them build emotional resilience, social courage, and communicative skills. They described increased perspective-taking, better understanding of cultural differences, and stronger abilities to handle social uncertainty. Expressed challenges included fear of mistakes, unfamiliar group settings, and linguistic barriers, especially among those less confident in Swedish or their mother tongue. Youth suggested improvements such as simplified language, visual materials, and more interactive and flexible session formats.Discussion: Findings underscore the importance of culturally sensitive dialogical spaces in schools to support integration beyond academic achievements. Findings highlight the value of incorporating culturally representative role models who serve as facilitators, using culturally responsive practices, and providing flexible interventions. These facilitators help foster reflection and connection, making the PIA Youth Program a meaningful contributor to participants’ integration journey.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_justesenlise_2025, title = {Facilitating involvement of nursing home residents in food-related activities in breakfast clubs : A qualitative inquiry}, author = {Justesen, Lise and Kristensen, Søren Tange and Walter, Ute and Kristensen, Niels Heine}, year = {2025}, journal = {Clinical Rehabilitation}, volume = {39}, number = {3}, pages = {399--409}, doi = {10.1177/02692155241310121}, url = {1946749}, language = {eng}, publisher = {Sage Publications}, keywords = {meals; hospitality; multi-method field intervention; rehabilitation; reminiscent}, abstract = {Objective: To explore how healthcare professionals facilitate nursing home residents' involvement in food-related activities in two breakfast clubs based on a hospitality and reminiscences approach.Design: Qualitative one-year intervention studyParticipantsNineteen residents and twelve healthcare professionals.Method: The data were based on observation and debriefing notes from 29 breakfast club events, including 20 ladies' club events and 9 men's club events. Additionally, 13 interviews were conducted with residents, while 10 interviews were carried out with health care professionals. Data were subjected to thematic analysis and categorized into themes about how healthcare professionals can facilitate involvement in food-related activities.Results: Five ways of facilitating involvement were identified. Recognizable meal routines and structure, combined with facilitating shifting host and guest roles, created a secure space for residents and formed the basis for involvement in food-related activities. Facilitating dialogues based on a reminiscence approach helped residents become authors of their own identities and facilitating co-creation supported mutual learning processes both for residents and healthcare professionals and allowed residents to negotiate their value as a club participant. Improvisation created opportunities for co-creating new social practices and new ways for residents to represent themselves.Conclusion: Involving nursing home residents in food-related activities is a potential rehabilitation arena, but new competencies for healthcare professionals are needed. They include meal-preparation and hospitality competencies and the ability to support residents in transferring valuable past experiences into present and future intentions. In addition, rehabilitation can be considered as mutual learning processes with shared, negotiated goals.}, issn = {0269-2155} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rtenwallchristoffer_2025, title = {Failure to rescue in patients with anastomotic leakage after anterior resection for rectal cancer : predictive factors}, author = {Örtenwall, Christoffer and Häggström, Jenny and Matthiessen, Peter and Nordenvall, Caroline and Rutegård, Martin}, year = {2025}, journal = {British Journal of Surgery}, volume = {112}, number = {Suppl. 11}, pages = {xi17--xi18}, doi = {10.1093/bjs/znaf149.062}, url = {1992680}, language = {eng}, publisher = {Oxford University Press}, abstract = {Introduction: Anastomotic leakage after anterior resection for rectal cancer is a common and potentially dangerous complication, resulting in morbidity and sometimes mortality. The rate of failure to rescue (FTR), or death after leakage, has previously been reported at 6-7% within 90 days. The aim of this study was to investigate the incidence of and predictive factors for FTR in a modern population-based cohort.Method: This retrospective, nationwide registry-based study included patients from the Colorectal Cancer Database Sweden (CRCBaSe) who had undergone anterior resection for rectal cancer between 2007 to 2021. Patients without a registered leakage were excluded. Predictive factors were investigated in a multiple logistic regression model and included age, American Society of Anaesthesiologists’ classification, sex, obesity, cardiovascular disease, diabetes, education, hospital volume and defunctioning stoma use. The primary endpoint was FTR within 90 days of surgery.Result: A total of 637 patients with leakage were identified, of whom 19 (2.8%) died within 90 days. High age was predictive of FTR (odds ratio (OR): 1.14; 95% CI: 1.06–1.23). Male sex (OR: 1.76; 95% CI: 0.52–5.90) and cardiovascular disease (OR 2.59; 95% CI: 0.90–7.47) were also related to FTR, but not statistically significantly.Discussion: The FTR within 90 days after anterior resection for rectal cancer is low in routine Swedish healthcare. The only strong predictor for FTR was high age, while ASA classification unexpectedly did not confer any predictive value in presence of other covariates.}, issn = {0007-1323} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_calatravanicolsfrancisco_2025_1, title = {FAME : Feature-Augmented Multi-View Ensemble Framework for Human Activity Recognition using Inertial Sensors}, author = {Calatrava Nicolás, Francisco and Shakti Swarup Ray, Lala and Fortes Rey, Vitor and Lukowicz, Paul and Martínez Mozos, Oscar}, year = {2025}, pages = {964--969}, doi = {10.1145/3714394.3756194}, url = {2015898}, language = {eng}, keywords = {ensemble; muti-view; deep learning; human activity recognition}, abstract = {This technical report presents the approach and insights of team “Whatever” for the 2nd Edition of the WEAR Challenge. This challenge proposes an inertia-based Human Activity Recognition (HAR) problem focused on identifying sports activities using data collected by wearable sensors. To address this, we propose a multi-view ensemble model considering each view as the set of symmetrically worn sensors (i.e., right/left arm). The model is composed of an early encoder that shares weights across the views, followed by two view-specific branches (wrist and legs). We further encourage similarity between symmetric sensor positions by adding a similarity component to the loss function. We enrich inputs with frequency-domain and PCA features plus data augmentation. Our evaluation revealed that frequency-domain features and channel-wise random sign-flipping data augmentation were the main drivers of generalization, mirroring patterns seen on the challenge test set. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vosmelissa_2025, title = {Familial co-aggregation and shared familiality among neurodevelopmental problems and with aggressive behavior, depression, anxiety, and substance use}, author = {Vos, Melissa and Wang, Rujia and Rommelse, Nanda N. J. and Snieder, Harold and Larsson, Henrik and Hartman, Catharina A.}, year = {2025}, journal = {Psychological Medicine}, volume = {54}, number = {16}, pages = {4820--4832}, doi = {10.1017/S003329172400309X}, url = {1921830}, language = {eng}, publisher = {Cambridge University Press}, keywords = {adhd; asd; familial co-aggregation; multigenerational family study; shared familiality}, abstract = {OBJECTIVE: To refine the knowledge on familial transmission, we examined the (shared) familial components among neurodevelopmental problems (i.e. two attention-deficit/hyperactivity-impulsivity disorder [ADHD] and six autism spectrum disorder [ASD] subdomains) and with aggressive behavior, depression, anxiety, and substance use.METHODS: Data were obtained from a cross-sectional study encompassing 37 688 participants across three generations from the general population. ADHD subdomains, ASD subdomains, aggressive behavior, depression, anxiety, and substance use were assessed. To evaluate familial (co-)aggregation, recurrence risk ratios (λR) were estimated using Cox proportional hazards models. The (shared) familiality (f2), which is closely related to (shared) heritability, was assessed using residual maximum likelihood-based variance decomposition methods. All analyses were adjusted for sex, age, and age2.RESULTS: The familial aggregation and familiality of neurodevelopmental problems were moderate (λR = 2.40-4.04; f2 = 0.22-0.39). The familial co-aggregation and shared familiality among neurodevelopmental problems (λR = 1.39-2.56; rF = 0.52-0.94), and with aggressive behavior (λR = 1.79-2.56; rF = 0.60-0.78), depression (λR = 1.45-2.29; rF = 0.43-0.76), and anxiety (λR = 1.44-2.31; rF = 0.62-0.84) were substantial. The familial co-aggregation and shared familiality between all neurodevelopmental problems and all types of substance use were weak (λR = 0.53-1.57; rF = -0.06-0.35).CONCLUSIONS: Neurodevelopmental problems belonging to the same disorder were more akin than cross-disorder problems. That said, there is a clear (shared) familial component to neurodevelopmental problems, in part shared with other psychiatric problems (except for substance use). This suggests that neurodevelopmental disorders, disruptive behavior disorders, and internalizing disorders share genetic and environmental risk factors.}, issn = {0033-2917} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_adolfssonemma_2025_1, title = {Familial hypercholesterolemia : Targeted whole gene sequencing as a diagnostic approach}, author = {Adolfsson, Emma and Fredriksson, Nils Johan and Jonasson, Jon and Nordenskjöld, Anna M. and Green, Anna}, year = {2025}, journal = {Atherosclerosis plus}, volume = {59}, pages = {9}, doi = {10.1016/j.athplu.2024.12.001}, url = {1927543}, language = {eng}, publisher = {Elsevier}, keywords = {copy number variation; familial hypercholesterolemia; genetic testing; low density lipoprotein receptor; sequence analysis}, abstract = {BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) and other disorders with similar features are common genetic disorders that remain underdiagnosed and undertreated, due in part to the cost of screening. The aim of this study was to design and implement a whole gene targeted NGS panel for the molecular diagnosis of FH and statin intolerance with an emphasis on high quality variant calling, including copy number analysis.METHODS: A whole gene panel for hybridisation-based short read NGS was designed for the dominant FH-genes low density lipoprotein receptor (LDLR), apolipoprotein B (APOB), proproteinconvertas subtilisin/kexin type 9 (PCSK9), apolipoprotein E (APOE) and the recessive FH-genes low density lipoprotein receptor adaptor protein 1 (LDLRAP1), ATP binding cassette subfamily member 5/8 (ABCG5/8) and lipase A, lysosomal acid type (LIPA), as well as solute carrier organic anion transporter family member 1B1 (SLCO1B1), not an FH gene but linked to statin intolerance. Polygenetic risk score markers were also included. The panel was used for screening of a Swedish FH-study population (n = 133).RESULTS: The panel sequencing resulted in high coverage and confident variant calling of included genes. Known causal variants were found in common dominant FH-genes in 43 % of the cohort. Copy number variants were found in LDLR in 10 individuals and a whole gene deletion of SLCO1B1 in one individual. In addition, coding variants in recessive genes and rare non-coding intronic and untranslated region variants were found in a large proportion of the study individuals highlighting the need for extended gene panels.CONCLUSIONS: This new tool can be used for a comprehensive high-quality molecular genetic analysis according to guidelines for the diagnosis and treatment of FH.}, issn = {2667-0909} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hakanssonfeliciahk_2025, title = {Familial risk of myocardial infarction with non-obstructive and obstructive coronary arteries : A nation-wide cohort study}, author = {Hakansson, Felicia H. K. and Svensson, Per and Pettersson, Hans J. and Ehrenborg, Ewa and Spaak, Jonas and Nordenskjöld, Anna M. and Eggers, Kai M. and Tornvall, Per}, year = {2025}, journal = {European Journal of Preventive Cardiology}, volume = {32}, number = {8}, pages = {671--679}, doi = {10.1093/eurjpc/zwae313}, url = {1903976}, language = {eng}, publisher = {Oxford University Press}, keywords = {mi-cad; minoca; coronary angiography; familial risk}, abstract = {BACKGROUND AND AIMS: The familial risk among patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) is unknown. Previous studies of family history in myocardial infarction (MI), have not made a distinction between MINOCA and MI due to coronary artery disease (MI-CAD), based on angiographic findings. We therefore sought to investigate familial risk of MI without and with obstructive coronary arteries.METHODS: Register-based cohort study with a total of 15,462 MINOCA cases, 204,424 MI-CAD cases, 38,220 control subjects without MI and with non-obstructive coronary arteries. First-degree relatives were identified 1995-2020. Cox proportional hazard regression models were used to compare familial risk in MINOCA and MI-CAD with control subjects.RESULTS: During a mean follow-up of 8.1 ± 4.2 years, MINOCA occurred in 1.0% of first-degree relatives with MINOCA whereas MI-CAD occurred in 9.7% of first-degree relatives of MINOCA. The age- and sex-adjusted hazard ratio (HR) for a MINOCA-relative experiencing MINOCA and MI-CAD, compared to control subjects, was 0.99 (95% confidence interval [CI] 0.80-1.23) and 1.10 (95% CI 1.03-1.18), respectively. During a mean follow-up of 8.5 ±4.8 years, MI-CAD occurred in 12.2% of first- degree relatives with MI-CAD with age- and sex-adjusted HR 1.43 (95% CI 1.37-1.49).CONCLUSIONS: No increased familial risk of MINOCA was observed for MINOCA-patients whereas there was an increased familial risk for MI-CAD when compared to control subjects. These results may indicate that genetic factors and shared environmental factors within a family leading to CAD are important also for MINOCA, thus MI-CAD and MINOCA could share underlying mechanisms.}, issn = {2047-4873} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_4, title = {Families Aren’t the Problem — Insecurity Is}, author = {Johansson Wilén, Evelina}, year = {2025}, journal = {Jacobin}, number = {27 September}, url = {2001824}, language = {eng}, publisher = {Jacobin Press}, issn = {2470-6930} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_5, title = {Family abolitionism. A Critique : Capitalist kids and kids as capital}, author = {Johansson Wilén, Evelina}, year = {2025}, url = {2011428}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_deutschmannmats_2025_1, title = {Family Engagement in Reading for Pleasure with Young Children in the Seychellois Home : What Does it Look Like?}, author = {Deutschmann, Mats and Pardiwalla, Mahrookh and de Comarmond, Odile}, year = {2025}, journal = {Seychelles Research Journal (SRJ)}, volume = {7}, number = {special issue}, pages = {80--102}, doi = {10.5281/zenodo.16919396}, url = {1998028}, language = {eng}, publisher = {University of Seychelles}, keywords = {literacy support; reading to young children; seychelles; seselwa; sesel lir avek mwan}, abstract = {Extensive research demonstrates that early exposure to reading significantly enhances a child’s academic and life outcomes. Moreover, reading for pleasure can help bridge socio-economic disparities. In response to this, the Seychelles Association of Retired Education Professionals (SAREP) launched Sesel Lir Avek Mwan (SLAM), a community-based literacy support programme. As part of this initiative, a baseline study was conducted to explore the extent to which a culture of reading for pleasure is embedded in Seychellois households. Between June 2023 and September 2024, seventeen introductory SLAM workshops were held across Mahé, targeting parents and caregivers. Participants were invited to complete a Home Literacy Survey (HLS); 167 out of 224 attendees responded. While the non-random sample and limited size constrain generalizability, the findings offer valuable insight into home literacy practices in Seychelles. Results revealed that daily shared reading with young children is uncommon. Less than 20% of respondents read to their children daily, and over 70% reported reading for less than 30 minutes per week. Older and more educated parents were somewhat more likely to engage in reading yet, across the board, reading was often perceived as a school-preparation task rather than a pleasurable activity. This utilitarian view may deter both parents and children from enjoying reading, especially when it becomes another duty in an already demanding routine – often one disproportionately shouldered by mothers. The study highlights the need to shift perceptions of reading from obligation to enjoyment, encourage broader household involvement (including fathers), and improve access to culturally-relevant books, particularly in Kreol Seselwa. Furthermore, while printed books remain limited, digital resources offer potential – provided they are of high quality and used with adult interaction. Promoting reading for pleasure through media, daycare facilities, and community institutions is essential to fostering a more active reading culture in Seychelles.}, file = {https://oru.diva-portal.org/smash/get/diva2:1998028/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_drakenberganna_2025, title = {Family Involvement in Relation to Elective Open-Heart Surgery : A Critical Incident Technique Study From a Family Member Perspective}, author = {Drakenberg, Anna and Sundqvist, Ann-Sofie and Fridlund, Bengt and Ericsson, Elisabeth}, year = {2025}, journal = {Scandinavian Journal of Caring Sciences}, volume = {39}, number = {1}, doi = {10.1111/scs.70003}, url = {1940305}, language = {eng}, publisher = {Blackwell Publishing}, keywords = {critical incident technique; family involvement; family‐centered care; open‐heart surgery; qualitative research; social support}, abstract = {BACKGROUND: As open-heart surgery can be stressful for the patient and their family, the objective of this study was to generate knowledge on how to support families in relation to open-heart surgery based on important situations.AIM: The aim was to explore and describe the experiences and actions of important situations of family involvement as expressed by family members of patients who underwent elective open-heart surgery in Sweden. METHODOLOGICAL DESIGN AND JUSTIFICATION: The critical incident technique used is a qualitative method appropriate for identifying issues relating to clinical problems.ETHICAL ISSUES AND APPROVAL: Ethical approval was obtained from the Swedish Ethical Review Authority. Allowance was made for the unexpected presence of the patient.RESEARCH METHODS: Individual interviews with 29 family members of patients who underwent open-heart surgery in Sweden in 2023 were analysed using the critical incidence technique, as applied in nursing and healthcare sciences. RESULTS: The family members experienced being-or not being-seen as significant and were fearing the loss of normal life in relation to open-heart surgery. Actions taken during important situations were building confidence to relinquish control and relieving burdens to improve well-being.CONCLUSIONS: Family involvement, in terms of being informed and welcomed, led to an improved ability to care for their loved ones. Emotionally supportive interventions targeting families should be considered in relation to a loved one's open-heart surgery.}, issn = {0283-9318} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_merkifeldgabrieles_2025, title = {Family planning and contraception in people with multiple sclerosis : perspectives for obstetricians, gynaecologists, and other health care professionals involved in reproductive planning}, author = {Merki-Feld, Gabriele S. and Bove, Riley and Haddad, Lisa B. and Hellwig, Kerstin and Hillert, Jan and Houtchens, Maria and Magyari, Melinda and Montgomery, Scott and Simoni, Manuela and Stenager, Egon and Thompson, Heidi and Tulek, Zeliha and Marhardt, Kurt and Nappi, Rossella E.}, year = {2025}, journal = {European journal of contraception & reproductive health care}, volume = {30}, number = {2}, pages = {59--73}, doi = {10.1080/13625187.2024.2434843}, url = {1921986}, language = {eng}, publisher = {Taylor & Francis}, keywords = {multiple sclerosis; contraception; disease-modifying therapy; expert opinion; gynaecologist; neurologist; obstetrician}, abstract = {PURPOSE: Multiple sclerosis (MS) is often diagnosed in people of reproductive age. However, family planning counselling is not always integrated within MS care. Decisions on family planning can be further complicated by potential side effects associated with several disease-modifying therapies. While neurologists may lack training in contraceptive use and family planning counselling, obstetricians and gynaecologists (OB-GYNs) and other health care professionals involved in reproductive life planning (RHCPs) may lack detailed knowledge and experience around the use of contemporary MS treatments.MATERIAL AND METHODS: Through a modified Delphi consensus programme, a multidisciplinary steering committee of 13 international experts developed practical clinical recommendations on contraceptive use and family planning for people with MS (PwMS). This article offers insights to help OB-GYNs and RHCPs implement these recommendations, focusing on contraceptive decision-making and MS medications.RESULTS: The perspectives discussed emphasise providing education on MS to OB-GYNs and other RHCPs, enabling informed counselling for PwMS and their partners regarding contraception and family planning. Close collaboration among the multidisciplinary team, including neurologists, is crucial in providing reproductive care for PwMS.CONCLUSIONS: The detailed perspectives provided aim to enable OB-GYNs and other RHCPs to provide informed counselling for PwMS and their partners regarding contraception and family planning.}, issn = {1362-5187} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_petersnanna_2025, title = {Family social workers’ experiences of using the Swedish model after the child forensic interview : [Familjebehandlares erfarenheter av att använda den svenska modellen Efter barnförhöret]}, author = {Petersén, Anna and Sandelin, Lisa and Thunberg, Sara and Källström, Åsa}, year = {2025}, journal = {European Journal of Social Work}, volume = {28}, number = {3}, pages = {565--576}, doi = {10.1080/13691457.2025.2479096}, url = {1947861}, language = {eng}, publisher = {Routledge}, keywords = {child abuse; after the child forensic interview; efter barnförhöret; social services; forensic interview; barnmisshandel; socialtjänst; barnförhör}, abstract = {Children interviewed by the police in cases of suspected child abuse may experience emotional distress. Simultaneously, parents face the dual challenge of being suspects in the investigation while also striving to support their child’s well-being. To offer children and their parents information and support in such cases, social workers in Sweden developed the model After the Child Forensic Interview (ACFI, sw. Efter barnförhöret). This study aims to explore the model from the perspective of family social workers to understand its relevance for supporting children and parents. Twenty family social workers from eleven Swedish municipalities were interviewed about their experiences of working with ACFI. The analysis revealed that working with ACFI (a) requires preconditions such as resources and cooperation, individual/professional knowledge and experience, and the parents’ receptivity, (b) demands adaptations such as changes and additions, and (c) entails side effects. Overall, family social workers describe the model as beneficial as it can improve client-worker relationships and facilitate further interventions. However, it is required that the municipalities have a plan for implementation and allocation of resources.;Barn som förhörs av polisen vid misstanke om barnmisshandel kan uppleva känslomässig påfrestning. Samtidigt möter föräldrar den dubbla utmaningen att både vara misstänkta i utredningen och att försöka stödja sitt barns välbefinnande. För att ge barn och deras föräldrar information och stöd i sådana situationer utvecklade socialarbetare i Sverige modellen Efter barnförhöret (EBF). Denna studie syftar till att utforska modellen utifrån familjebehandlares perspektiv för att förstå dess relevans i arbetet med att stödja barn och föräldrar. Tjugo familjebehandlare från elva svenska kommuner intervjuades om sina erfarenheter av att arbeta med EBF. Analysen visade att arbetet med EBF: (a) kräver förutsättningar, såsom resurser och samverkan, individuell/professionell kunskap och erfarenhet samt föräldrarnas mottaglighet, (b) kräver anpassningar, såsom förändringar och tillägg, och (c) medför bieffekter. Familjebehandlarna beskriver EBF som gynnsam, då de uppfattar att den kan förbättra klientrelationer samt underlätta vidare insatser. För gynnsamhet krävs dock att kommunerna har en plan för implementering och resursfördelning.}, issn = {1369-1457}, file = {https://oru.diva-portal.org/smash/get/diva2:1947861/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_darwishmaria_2025, title = {Fascism, nature and communication : a Discursive-affective analysis of cuteness in ecofascist propaganda}, author = {Darwish, Maria}, year = {2025}, journal = {Feminist Media Studies}, volume = {25}, number = {2}, pages = {443--463}, doi = {10.1080/14680777.2024.2313006}, url = {1844959}, language = {eng}, publisher = {Routledge}, keywords = {ecofascism; cuteness; masculinities; nordic; far-right propaganda}, abstract = {Ecofascism-the union of fascist ideas and ecological notions-is a rising global issue. Ecofascism in the online sphere often encompasses imaginaries of utopia, love and nostalgia in concert with militarism and violence. This article examines cuteness as a strategic tool used to arouse culturally deemed "positive" emotions like joy, love and pleasure. The study draws on findings from an affective-discursive analysis of visual propaganda in the form of ecofascist memes. The analysis shows that cuteness softens fascist ideology and remasculinises and humanises fascism. Cuteness as a rhetorical tool lessens the needs for ideological defence, since cute signifiers condense structures of meaning into binaries of good and evil. Hence, the article argues that cuteness is a powerful affective political communication strategy that serves to reproduce masculine dominance by mobilising gendered and racialised imaginaries of nature, protection, empathy and belonging.}, issn = {1468-0777} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_zhuyufei_2025, title = {Fast Online Learning of CLiFF-Maps in Changing Environments}, author = {Zhu, Yufei and Rudenko, A. and Palmieri, L. and Heuer, Lukas and Lilienthal, Achim and Magnusson, Martin}, year = {2025}, pages = {10424--10431}, doi = {10.1109/ICRA55743.2025.11127602}, url = {2028812}, language = {eng}, publisher = {Institute of Electrical and Electronics Engineers Inc.}, abstract = {Maps of dynamics are effective representations of motion patterns learned from prior observations, with recent research demonstrating their ability to enhance various downstream tasks such as human-aware robot navigation, long-term human motion prediction, and robot localization. Current advancements have primarily concentrated on methods for learning maps of human flow in environments where the flow is static, i.e., not assumed to change over time. In this paper we propose an online update method of the CLiFF-map (an advanced map of dynamics type that models motion patterns as velocity and orientation mixtures) to actively detect and adapt to human flow changes. As new observations are collected, our goal is to update a CLiFF-map to effectively and accurately integrate them, while retaining relevant historic motion patterns. The proposed online update method maintains a probabilistic representation in each observed location, updating parameters by continuously tracking sufficient statistics. In experiments using both synthetic and real-world datasets, we show that our method is able to maintain accurate representations of human motion dynamics, contributing to high performance flow-compliant planning downstream tasks, while being orders of magnitude faster than the comparable baselines. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_whisspera_2025, title = {Fasting plasma C-peptide correlates with body mass index, hsCRP, apolipoprotein B, and other atherogenic lipids in healthy individuals}, author = {Whiss, Per A. and Baldimtsi, Evangelia and Wahlberg, Jeanette}, year = {2025}, journal = {Physiological Reports}, volume = {13}, number = {6}, doi = {10.14814/phy2.70282}, url = {1947487}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {c‐peptide; apolipoprotein b; body mass index; healthy volunteers; lipoproteins}, abstract = {C-peptide has a complex role in human physiology, but its effects are not fully understood. Studies have shown a protective impact against diabetic complications, but also that C-peptide levels associate with cardiovascular events. Among the many applications to assess cardiovascular risk, circulating lipids are widely used, and one of the strongest biomarkers is apolipoprotein B. The aim of this investigation was to study the association of C-peptide with markers of metabolic, inflammatory, or cardiovascular alterations in a limited group of healthy individuals. Body mass index (BMI), lipids, and other plasma markers were studied in 28 consecutive healthy individuals within the age of 30-50 years. The results showed significant positive correlations between C-peptide and BMI (r = 0.498; p = 0.007); hsCRP (r = 0.530; p = 0.004); triglycerides (r = 0.530; p = 0.005); cholesterol (r = 0.507; p = 0.006), LDL-cholesterol (r = 0.550; p = 0.002), LDL/HDL ratio (r = 0.460; p = 0.014); apoB (r = 0.622; p < 0.001), apoB/apoA1 ratio (r = 0.563; p = 0.002); and non-HDL cholesterol (r = 0.566; p = 0.002). According to BMI values, 16 of the 28 individuals were overweight (BMI >25.0 kg/m2). If overweight individuals were excluded, C-peptide did only correlate with apoB (r = 0.636; p = 0.026). To conclude, C-peptide within normal levels associate with BMI and atherogenic lipids in healthy individuals, and apoB associate with C-peptide even at normal weight. These results suggest that C-peptide can be an early additional cardiovascular risk marker.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_arnelllinda_2025_2, title = {Fear and loss : Violent fathers’ impact on children’s and mothers’ lives after fleeing from home}, author = {Arnell, Linda and Thunberg, Sara}, year = {2025}, journal = {Children and youth services review}, volume = {175}, doi = {10.1016/j.childyouth.2025.108375}, url = {1962589}, language = {eng}, publisher = {Elsevier}, keywords = {children; domestic violence shelters; leaving process; violence; visitation rights}, abstract = {The aim of this study was to investigate violent fathers’ impact on children’s and mothers’ lives after fleeing violence in their homes. The study is based on interviews with children aged 7–17 (n=13) and mothers (n=14) of young children (age 0–6 years) in Sweden. Eight children and five mothers in the sample were still living in domestic violence shelters at the time of the interview. The thematic analysis resulted in two major themes, Fear and Loss, revealing the fear of violence, abduction, and the consequences of visitation, and the loss of home, social relations, and identity. The results are discussed with the help of the UN Convention on the Rights of the Child. The conclusion shows that the impact of fathers’ violence has far-reaching consequences, both directly and indirectly, and that children’s and mothers’ lives continue to be affected long after they leave their home to seek protection.}, issn = {0190-7409} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gustafssonm_2025, title = {Fear of receiving compassion from others moderates the association between self-compassion and depressive symptoms in women with breast cancer}, author = {Gustafsson, M. and Ismail, A. and Störe, Siri Jakobsson and Blomqvist-Storm, M. and Trindade, Ines}, year = {2025}, journal = {Journal of Psychosocial Oncology Research and Practice}, volume = {7}, number = {4}, doi = {10.1097/OR9.0000000000000185}, url = {2028210}, language = {eng}, publisher = {Wolters Kluwer}, keywords = {anxiety; breast cancer; depression; fear of compassion; self-compassion; stress}, abstract = {Background: Breast cancer, the most prevalent cancer among women in Portugal, significantly affects both physical and psychological well-being. Recent research has emphasized the beneficial effects of self-compassion and the consequences that fear of receiving compassion has on mental health. This study examined fear of receiving compassion from others as a moderator of the relationships of self-compassion with symptoms of depression, anxiety, and stress.Methods: Portuguese women (N = 78) with nonmetastatic breast cancer completed self-report measures of interest (depression, anxiety, stress, and self-compassion). Data were analyzed using the PROCESS macro for moderation analysis.Results: The relationship between self-compassion and depressive symptoms was influenced by fear of receiving compassion from others. This relationship was statistically significant when the fear was moderate or high, but it was not statistically significant when the fear was low. The relationships between self-compassion and both anxiety and stress were not affected by fear of receiving compassion from others.Conclusions: This is the first study to explore fear of receiving compassion from others as a moderating factor of the relationship between self-compassion and psychological distress in women with breast cancer. More longitudinal, compassion-based intervention studies targeting fear of receiving compassion, as well as qualitative studies of patients' experiences of self-compassion, fear of compassion, and compassion-based interventions, should be conducted. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hansensimenhyll_2025, title = {Fecal Microbiome Reflects Disease State and Prognosis in Inflammatory Bowel Disease in an Adult Population-Based Inception Cohort}, author = {Hansen, Simen Hyll and Maseng, Maria Gjerstad and Grännö, Olle and Vestergaard, Marie V. and Bang, Corinna and Olsen, Bjørn C. and Lund, Charlotte and Olbjørn, Christine and Løvlund, Emma E. and Vikskjold, Florin B. and Huppertz-Hauss, Gert and Perminow, Gøri and Yassin, Hussain and Valeur, Jørgen and Aass Holten, Kristina I. and Henriksen, Magne and Bengtson, May-Bente and Ricanek, Petr and Opheim, Randi and Boyar, Raziye and Torp, Roald and Frigstad, Svein O. and Aabrekk, Tone Bergene and Detlie, Trond Espen and Kristensen, Vendel A. and Strande, Vibeke and Hovde, Øistein and Asak, Øyvind and Jess, Tine and Franke, Andre and Halfvarson, Jonas and Høivik, Marte L. and Hov, Johannes R.}, year = {2025}, journal = {Inflammatory Bowel Diseases}, volume = {31}, number = {8}, pages = {2066--2080}, doi = {10.1093/ibd/izaf060}, url = {1954817}, language = {eng}, publisher = {Oxford University Press}, keywords = {crohn’s disease; ibsen; machine learning; ulcerative colitis}, abstract = {INTRODUCTION: We aimed to determine the diagnostic and prognostic potential of baseline microbiome profiling in inflammatory bowel disease (IBD).METHODS: Participants with ulcerative colitis (UC), Crohn's disease (CD), suspected IBD, and non-IBD symptomatic controls were included in the prospective population-based cohort Inflammatory Bowel Disease in South-Eastern Norway III (third iteration) based on suspicion of IBD. The participants donated fecal samples that were analyzed with 16S rRNA sequencing. Disease course severity was evaluated at the 1-year follow-up. A stringent statistical consensus approach for differential abundance analysis with 3 different tools was applied, together with machine learning modeling.RESULTS: A total of 1404 individuals were included, where n = 1229 samples from adults were used in the main analyses (n = 658 UC, n = 324 CD, n = 36 IBD-U, n = 67 suspected IBD, and n = 144 non-IBD symptomatic controls). Microbiome profiles were compared with biochemical markers in machine learning models to differentiate IBD from non-IBD symptomatic controls (area under the receiver operating curve [AUC] 0.75-0.79). For UC vs controls, integrating microbiome data with biochemical markers like fecal calprotectin mildly improved classification (AUC 0.83 to 0.86, P < .0001). Extensive differences in microbiome composition between UC and CD were identified, which could be quantified as an index of differentially abundant genera. This index was validated across published datasets from 3 continents. The UC-CD index discriminated between ileal and colonic CD (linear regression, P = .008) and between colonic CD and UC (P = .005), suggesting a location-dependent gradient. Microbiome profiles outperformed biochemical markers in predicting a severe disease course in UC (AUC 0.72 vs 0.65, P < .0001), even in those with a mild disease at baseline (AUC 0.66 vs 0.59, P < .0001).CONCLUSIONS: Fecal microbiome profiling at baseline held limited potential to diagnose IBD from non-IBD compared with standard-of-care. However, microbiome shows promise for predicting future disease courses in UC.}, issn = {1078-0998} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_websternatashaa_2025, title = {Feelings at work : A retrospective discussion of emotional geographies of work}, author = {Webster, Natasha A. and Lin, Chih-Chen Trista}, year = {2025}, journal = {Emotion, Space and Society}, volume = {56}, doi = {10.1016/j.emospa.2025.101071}, url = {1941221}, language = {eng}, publisher = {Elsevier}, keywords = {emotion; work}, issn = {1755-4586} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_landstrmcatharina_2025, title = {Feministiska teknik- och vetenskapsstudier}, author = {Landström, Catharina and Soneryd, Linda}, year = {2025}, pages = {215--230}, url = {2023218}, language = {swe}, publisher = {Studentlitteratur AB} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_slettmyranna_2025, title = {Fight or flight-intensive care nurses' decisions to resign following the COVID-19 pandemic : a phenomenological hermeneutical study}, author = {Slettmyr, Anna and Schandl, Anna and Arman, Maria and Hugelius, Karin}, year = {2025}, journal = {BMC Nursing}, volume = {24}, number = {1}, doi = {10.1186/s12912-025-02956-7}, url = {1949309}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {covid-19; icu; intensive care nurses; nursing management; phenomenological hermeneutical}, abstract = {Background: Many intensive care unit (ICU) nurses who were crucial to the frontline response during the COVID-19 pandemic left their employment during or after the pandemic. Studies exploring the experiences of these nurses are lacking. The aim of this study was to explore ICU nurses' course towards making the decision to resign from work in the ICU following the COVID-19 pandemic.Method: Advertisements on social media and a snowball sampling-inspired method were used to recruit 11 nurses from hospitals around Sweden who worked in an ICU during the pandemic and who then left employment. The participants were interviewed individually via telephone, online or in-person. An interview guide with a few open-ended questions was used to capture the nurses' narratives. The data were analysed using a phenomenological hermeneutical method.Results: The nurses were tangled in paradoxes, described as three themes: 'To give it all and yet feel insufficient', 'To experience togetherness and yet feel lonely' and 'To prioritise others and yet need to eventually prioritise oneself'. The decision to end their employment was ambivalent but necessary, made with relief and no regrets, but with sorrow. During this decision-making process, there may have been a window of opportunity during which nursing management or the health care service might have influenced the outcome.Conclusion: The ICU nurses' decision to resign was influenced by a tangle of challenging paradoxes that entailed ambivalence. The course to the decision to resign was marked by hesitancy. While it is important to understand and support nurses' willingness to care for patients during a crisis and to acknowledge their suffering as it relates to their professional efforts, it is also essential to address their individual struggles and needs.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_segrottjeremy_2025, title = {Finding the public in prevention science : A review of public involvement in family-based prevention intervention studies}, author = {Segrott, Jeremy and Kaur, Harshdeep and Amouri, Layan and Koning, Ina M.}, year = {2025}, url = {2002092}, language = {eng}, abstract = {Background: Involving members of the public in the development and evaluation of interventions is now widely recognised as important. Such involvement helps ensure that interventions meet the needs of target populations, optimise research processes (e.g. recruitment, data collection), and shape how findings are shared. A range of terms are used to describe this work, including public involvement, public engagement, community involvement, and coproduction. In this presentation we share findings from a literature review examining the extent to which studies of the development and evaluation of family-based prevention intervention have included public involvement. The review explored: 1) the scope and aims of public involvement within published studies; 2) the nomenclature used to describe public involvement; 3) use of frameworks or guidance; and 4) reported outcomes of involvement.Methods: A protocol and search strategy were devised to guide a systematic search of relevant published articles, covering the period from 2019 onwards. Multiple databases were searched for relevant articles, including Scopus and MEDLINE. A data extraction tool was used to summarise data on public involvement in each included paper, as well as the proportion of studies which included any form of public involvement. Findings were synthesised to examine how public involvement was used, its aims, and its reported outcomes.Results: The presentation summarises final results from this study. Emerging findings indicate that public involvement in the development and evaluation of family-based prevention interventions is often limited, and that there is significant variation in the extent to which it is reported by researchers.Discussion: We highlight key opportunities for strengthening public involvement in Prevention Science, including methodological guidance, reporting practices in publications, and building researcher capacity.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sernboelisabet_2025, title = {Finish line or starting shot? - analyzing the introduction of a professional license and Master's in Healthcare Counseling programs in Sweden}, author = {Sernbo, Elisabet and Hjortgren, Katarina}, year = {2025}, journal = {Social Work Education}, doi = {10.1080/02615479.2025.2488471}, url = {1953851}, language = {eng}, publisher = {Routledge}, keywords = {health social work; license; further education; professionalization; knowledge}, abstract = {This article focuses on the current professionalization process of health social work in Sweden, where the professional group-the first among social workers-has been granted a license requiring a specialist master's degree. The aim of this article is to analyze the experienced and expected effects of these changes. The empirical material consists of focus groups of health social workers who act as supervisors for students, as well as individual interviews with key persons at the first three universities offering the master's degree. The material has been thematically analyzed. Among the effects analyzed are jurisdictional clarity, strengthened professional self-esteem, and a strengthened knowledge base. These benefits are mirrored by potential drawbacks that include a lack of change in status or knowledge base, depending on how employers value the license, which students will apply and how the master's degree will be evaluated. The analysis shows that health social workers primarily expect validating effects on the profession. By contrast, the key persons expect to see changes: enhancing the use of research in practice and paving the way for further specializations in social work. These different standpoints highlight a potential conflict regarding the value of different types of knowledge in the process of professionalization.}, issn = {0261-5479} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rauschphilipp_2025, title = {First insights into microbial changes within an Inflammatory Bowel Disease Family Cohort study}, author = {Rausch, Philipp and Ratjen, Ilka and Tittmann, Lukas and Enderle, Janna and Wacker, Eike Matthias and Jaeger, Kathrin and Rühlemann, Malte Christoph and Franzpötter, Katrin and Ellul, Pierre and Kruse, Robert and Halfvarson, Jonas and Roggenbuck, Dirk and Ellinghaus, David and Jacobs, Gunnar and Krawczak, Michael and Schreiber, Stefan and Bang, Corinna and Lieb, Wolfgang and Franke, Andre}, year = {2025}, journal = {Gut microbes}, volume = {17}, number = {1}, doi = {10.1080/19490976.2025.2559119}, url = {2004032}, language = {eng}, publisher = {Taylor & Francis}, keywords = {16s; family cohort; ibd; dysbiosis; inflammatory bowel disease; microbiota; oralization}, abstract = {The prospective Kiel Inflammatory Bowel Disease (IBD) Family Cohort Study (KINDRED cohort) was initiated in 2013 to systematically and extensively collect data and biosamples from index IBD patients and their relatives, a population at high risk for IBD development. Regular follow-ups were conducted to collect updated health and lifestyle information, to obtain new biosamples, and to capture the incidence of IBD during development. By combining microbial data collected at successive time points with extensive anthropometric, medical, nutritional, and social information, this study aimed to characterize the factors influencing the microbiota in health and disease via detailed ecological analyses. Using a microbial dysbiosis metric based on the German KINDRED cohort, we identified strong and generalizable gradients within and across different external IBD cohorts for validation. These community gradients correspond strongly with IBD pathologies, physiological manifestations of inflammation (e.g. Bristol stool score, ASCA IgA, ASCA IgG), and genetic risk for IBD. Anthropometric and medical factors influencing fecal transit time strongly modify bacterial communities. Various Enterobacteriaceae (e.g. Klebsiella sp.) and opportunistic Clostridia pathogens (e.g. C. XIVa clostridioforme), characterize in combination with ectopically colonizing oral taxa (e.g. Veillonella sp. Cand. Saccharibacteria sp. Fusobacterium nucleatum) the distinct and chaotic IBD-specific communities. Weak community and physiological changes are further traceable in a small number of individuals, who developed IBD in the study's runtime. Our findings demonstrate broad-scale ecological patterns which indicate drastic state transitions of communities in IBD patients. These patterns appear to be universal across cohorts and influence physiological signs of inflammation, display increased resilience, but show only limited heritability/intrafamily transmission.}, issn = {1949-0976} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_sabukiranm_2025, title = {First the action has to be perceived for communication to take place}, author = {Sabu, Kiran M. and Renoux, Jennifer and Grosinger, Hermine J. and Saffiotti, Alessandro}, year = {2025}, pages = {84--90}, url = {2023172}, language = {eng}, publisher = {Technical University of Aachen}, keywords = {deliberative communication; human-robot interaction; human-agent communication; human-agent collaboration}, abstract = {In this short paper, we consider scenarios in human-robot collaboration where the robot relies on deliberation to activate communicative actions. We claim that reasoning about the perception of these actions is a key, but often disregarded ingredient for successful communication, and propose a pre-theoretical model that accounts for this. We also discuss the problems that may arise if perception is neglected when reasoning about communication.}, file = {https://oru.diva-portal.org/smash/get/diva2:2023172/FULLTEXT02.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fjordkvisterika_2025, title = {First-line managers' experience of guideline implementation during the COVID-19 pandemic}, author = {Fjordkvist, Erika and Eldh, Ann Catrine and Winberg, Madeleine and Joelsson-Alm, Eva and Hälleberg Nyman, Maria}, year = {2025}, journal = {Journal of Advanced Nursing}, volume = {81}, number = {11}, pages = {7181--7191}, doi = {10.1111/jan.16204}, url = {1853584}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {covid‐19 pandemic; clinical practice; first‐line manager; guidelines; implementation leadership; knowledge implementation}, abstract = {AIM(S): To explore first-line managers' experience of guideline implementation in orthopaedic care during the COVID-19 pandemic.DESIGN: A descriptive, qualitative study.METHODS: Semi-structured interviews with 30 first-line nursing and rehabilitation managers in orthopaedic healthcare at university, regional and local hospitals. The interviews were analysed by thematic analysis.RESULTS: First-line managers described the implementation of guidelines related to the pandemic as different from everyday knowledge translation, with a swifter uptake and time freed from routine meetings in order to support staff in adoption and adherence. The urgent need to address the crisis facilitated guideline implementation, even though there were specific pandemic-related barriers such as staffing and communication issues. An overarching theme, Hanging on to guidelines for dear life, is substantiated by three themes: Adapting to facilitate change, Anchoring safety through guidelines and Embracing COVID guidelines.CONCLUSION: A health crisis such as the COVID-19 pandemic can generate enabling elements for guideline implementation in healthcare, despite prevailing or new hindering components. The experience of guideline implementation during the COVID-19 pandemic can improve understanding of context aspects that can benefit organizations in everyday translation of evidence into practice.IMPLICATIONS FOR THE PROFESSION AND/OR PATIENT CARE: Recognizing what enabled guideline implementation in a health crisis can help first-line managers to identify local enabling context elements and processes. This can facilitate future guideline implementation.IMPACT: During the COVID-19 pandemic, the healthcare context and staff's motivation for guideline recognition and adoption changed. Resources and ways to bridge barriers in guideline implementation emerged, although specific challenges arose. Nursing managers can draw on experiences from the COVID-19 pandemic to support implementation of new evidence-based practices in the future.REPORTING METHOD: This study adheres to the EQUATOR guidelines by using Standards for Reporting Qualitative Research (SRQR). No Patient or Public Contribution.}, issn = {0309-2402} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_asgharnaveed_2025_2, title = {Flavivirus Replicon-Based Novel Vaccine Candidates Against Hepatitis C Virus}, author = {Asghar, Naveed and Maravelia, Panagiota and Ahlen, Gustaf and Jaafar, Rita and Frelin, Lars and Larsson, Olivia and Johansson, Christer and Sällberg, Matti and Johansson, Magnus}, year = {2025}, url = {2008424}, language = {eng}, abstract = {BackgroundChronic liver disease caused by Hepatitis C virus (HCV), contributes to a major health burden worldwide. Although chronic infections with the HCV can be effectively cured by antivirals, but the cured patients can be re-infected as they lack protective immune responses. In addition, the relatively high cost of the HCV treatment brings concerns about the accessibility, especially in the developing countries. Hence, there exists a need for cost effect vaccines with high efficiency to control and possibly eradicate HCV globally.MethodsWe have developed and utilized flavivirus replicons as delivery system to prime hepatitis-specific immune responses. We generated subgenomic replicons of Tick-borne encephalitis virus, Langat virus, West-Nile virus (WNV), and Kunjin virus (KUNV) expressing a fusion protein between the HCV NS3/4A and core protein of stork hepatitis B virus. Antigen expression and immunogenicity of these flavivirus replicons was evaluated in vitro and in vitro, respectively.ResultsTransfection experiments showed that the antigen expression by KUNV and WNV replicons was several folds higher than the antigen expression of control DNA plasmid with CMV promoter. In a murine model, KUNV replicon triggered a potent cellular immune response with respect to priming of HCV NS3/4A-specific T cells as determined by ELISpot, and polyfunctionality assays. In addition, vaccination with KUNV replicon also induced HCV NS3/4A-specific humoral immune response.ConclusionThese findings indicate that the KUNV replicon-based HCV vaccine can induce both the neutralizing antibodies and protective T cell responses. Thus, the newly developed KUNV replicon-based vaccine is an attractive candidate to provide protection against HCV.}, file = {https://oru.diva-portal.org/smash/get/diva2:2008424/FULLTEXT01.pdf} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_ohaganlaurenalex_2025_1, title = {Food Marketing and Selling Healthy Lifestyles with Science : Transhistorical Perspectives}, author = {O’Hagan, Lauren Alex and Eriksson, Göran}, year = {2025}, pages = {1--310}, doi = {10.4324/9781003450276}, url = {1927507}, language = {eng}, publisher = {Routledge}, abstract = {This book sets out to historicise our understanding of contemporary trends by studying the long relationship between science, food and drink marketing and the promotion of healthy lifestyles. It aims to bring together contemporary and historical research from a multimodal perspective, considering how scientific discourse and ideas about health and nutrition are channelled through visual and material culture.Using examples of advertisements, commercials and posters, the 16 chapters in this book will foster a cross-disciplinary and cross-temporal dialogue, uncovering links between past and present ways that manufacturers have capitalised upon scientific innovations to create new products or rebrand existing products and employed science to make claims about health and nutrition. They will, thus, demonstrate the continuity of science in food and drink marketing—even if fundamental ideas of nutrition have evolved over time. The book provides crucial new insights into the significance of the late nineteenth and early twentieth centuries as a period of innovation in food and drink marketing and showcasing how many of the marketing strategies employed today, in fact, have a far broader historical trajectory.It will be of great interest to students and scholars of Critical Food Studies, Media and Communication Studies, History of Science and Medicine and Cultural Studies, as well as nutritionists, dieticians, sportspeople, in addition to policymakers and practitioners working in the area of food and drink marketing.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hlmanchristoffer_2025, title = {“For Teaching Them to Read” : The Village Teacher in Eighteenth-Century Popular Education}, author = {Åhlman, Christoffer}, year = {2025}, journal = {History of Education}, volume = {54}, number = {2}, pages = {156--174}, doi = {10.1080/0046760X.2024.2422932}, url = {1919485}, language = {eng}, publisher = {Taylor & Francis}, keywords = {village teacher; popular education; eighteenth century; sweden}, abstract = {This article studies the role of the village teacher in three rural parishes in eighteenth-century western Sweden. Earlier research has shown that the clergy and parents were important in reaching high literacy rates in early modern Sweden. However, many parishes were sparsely populated, and many villages were far from the church, affecting teaching access. The Church of Sweden also had to use other educational strategies in these parishes. By studying traces in church accounts, visitation protocols and other handwritten sources, this article helps us better understand the village teacher’s role and the different sources of income this role could provide. It becomes clear that popular education had different strategies and was much more developed than existing research has shown. The role of the village teacher is part of the explanation of why Sweden successfully spread literacy.}, issn = {0046-760X} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hlmanchristoffer_2025_1, title = {Forestry actors and Nordic educational narratives on forests 1970s-2020s}, author = {Åhlman, Christoffer and Kortekangas, Otso}, year = {2025}, url = {1960659}, language = {eng}, keywords = {forestry; school textbooks; educational narratives; national narratives; agency}, abstract = {In our joint project, we investigate what different interpretations and meanings (e.g., economic, ecological, cultural, recreational) school textbooks have presented about forests in Sweden and Finland (1972–today). Our paper for Nordic Educational History is inspired by the conference themes “The role of the state and/or private companies”. We will especially look at which actors in Swedish and Finnish forests and forestry are singled out in the textbooks studied. Given that the Swedish and Finnish states are large owners of forests and state-owned companies are large actors in forest economy, is the role of the state explicated in the books in terms of forestry, economy but also forest destruction, climate change and nature loss? What about the big non-state-owned forest companies? Moreover, the curricula in both countries emphasize that pupils should get knowledge and skills about how our way of life affect nature and biodiversity locally and globally. We pose the critical question whether our educational systems are up to this task.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_pigamatteo_2025, title = {Framework for implementing treat-to-target in systemic lupus erythematosus routine clinical care : Consensus statements from an international task force}, author = {Piga, Matteo and Parodis, Ioannis and Touma, Zahi and Legge, Alexandra and Ugarte-Gil, Manuel F. and Hmamouchi, Ihsane and Gómez Puerta, José A. and Devilliers, Hervé and Zen, Margherita and Cho, Jiacai and Ziade, Nelly and Mucke, Johanna and Toro-Gutierrez, Carlos Enrique and Izuka, Shinji and Korsten, Peter and Kane, Baïdy S. Y. and Golder, Vera and Chong, Benjamin F. and Pons-Estel, Guillermo and Chasset, François and Arnaud, Laurent}, year = {2025}, journal = {Autoimmunity Reviews}, volume = {24}, number = {5}, doi = {10.1016/j.autrev.2025.103773}, url = {1938325}, language = {eng}, publisher = {Elsevier}, keywords = {consensus; lldas; remission; systemic lupus erythematosus; treat-to-target}, abstract = {Implementation of Treat-to-Target (T2T) in routine clinical practice remains low in systemic lupus erythematosus (SLE). Real-world data reveal excessive use of glucocorticoids (GCs) and frequently inadequate disease control. Here, an international task force convened to develop a consensus framework for implementing T2T in routine clinical care of adult patients with SLE. This T2T task force comprised an international panel of 22 physicians involved in the care of SLE and 3 lupus patient research partners. Following a scoping review and online discussions, during which definitions and instruments available for T2T in SLE were examined, the panel developed potential framework statements for implementing T2T in SLE, which were extensively discussed before being agreed upon by Delphi consensus. Additionally, the current challenges of implementing T2T in SLE and how future research may address these issues were analyzed. The framework comprises 5 overarching principles and 11 statements. Despite the absence of formal evidence that T2T offers superiority to conventional SLE management, T2T in SLE has been recommended for over a decade. This task force offers a framework for effectively implementing T2T in SLE from a real-life perspective, informing a wide range of physicians, including those outside the limited circle of lupus specialists.}, issn = {1568-9972} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sjholmmaria_2025_1, title = {Framing Obstetric Violence and Associated Rights to Respectful Care in Childbirth Through International Human Rights Law}, author = {Sjöholm, Maria}, year = {2025}, journal = {Melbourne Journal of International Law}, volume = {25}, number = {2}, pages = {286--315}, url = {1959263}, language = {eng}, publisher = {University of Melbourne}, keywords = {childbirth; autonomy; pathologisation; human rights law; gender; consent; förlossning; autonomi; patologisering; mänskliga rättigheter; samtycke}, issn = {1444-8602} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_reiserdaniel_2025_1, title = {Free vascularized fibula transfer for total wrist arthrodesis : A solution for failed wrist arthrodesis after wrist hemiarthroplasty extraction}, author = {Reiser, Daniel and Hedspång, Mattias and Sagerfors, Marcus}, year = {2025}, journal = {JPRAS Open}, volume = {46}, pages = {54--60}, doi = {10.1016/j.jpra.2025.08.016}, url = {1999009}, language = {eng}, publisher = {Elsevier}, keywords = {arthrodesis; arthroplasty; free fibula transfer; wrist}, abstract = {Salvage radiocarpal arthrodesis is an option in the treatment of failed wrist arthroplasty. If bony union is achieved the results can be comparable to primary wrist arthrodesis. Substantial bone loss and decreased vascularity of the bone may be an issue in some cases. The present case report describes the case of a 58-yearold man with posttraumatic wrist arthritis after an intraarticular distal radius fracture. He was treated with a wrist hemiarthroplasty which ultimately failed and was converted to a radiocarpal arthrodesis. After two failed arthrodeses with bone grafting and a dorsal locking plate, we performed a free vascularized fibula transfer which resulted in bony union and a pain-free wrist. Free vascularized fibula transfer may be a salvage option in select cases of failed radiocarpal arthrodesis.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_paganinianna_2025, title = {Frequency, demographics, and comorbidity of women with post-bariatric breast implants : A Swedish population-based controlled study}, author = {Paganini, Anna and Ottosson, Johan and Halle, Martin and Mirzaei, Nushin and Gudbjornsdottir, Soffia and Grimby-Ekman, Anna and Hansson, Emma}, year = {2025}, journal = {Journal of Plastic, Reconstructive & Aesthetic Surgery}, volume = {111}, pages = {145--155}, doi = {10.1016/j.bjps.2025.10.004}, url = {2009869}, language = {eng}, publisher = {Churchill Livingstone}, keywords = {breast augmentation; breast implant; plastic surgery; post-bariatric reconstruction}, abstract = {BACKGROUND: Obesity is a growing global health problem, and bariatric surgery is an effective treatment for severe obesity. However, massive weight loss frequently results in excess skin and altered breast morphology, resulting in some women seeking implant-based breast surgery. Evidence on the frequency and characteristics of post-bariatric women undergoing breast implant surgery is scarce, with only small case series published. We investigated the prevalence and demographics of such women compared with non-post-bariatric controls.METHODS: This national population-based case-control study used and linked data from Swedish registries. Women who underwent bariatric surgery (2008-2022) and subsequent benign implant surgery (after 2014) were identified and matched with non-bariatric controls who underwent breast augmentation by age and body mass index. Demographics, comorbidities, and drug data were analyzed and compared between the groups.RESULTS: Between 2014 and 2024, 817 post-bariatric women underwent breast implant surgery and were compared with 3512 matched controls. The frequency of implant surgery among women with previous bariatric surgery (2008-2013) was 2.8%. Post-bariatric women were more often divorced/separated, had lower education levels, and were more likely to have undergone previous breast or plastic surgery than the controls. They also had higher rates of psychiatric, endocrine, and gastrointestinal comorbidities, reflected in specialist care and prescription data.CONCLUSION: Post-bariatric women undergoing breast implant surgery constitute a distinct, medically more complex subgroup compared to non-post-bariatric implant patients. Their higher psychosocial vulnerability and comorbidity burden highlight the need for tailored clinical assessment, long-term support, and broader discussion on healthcare access for post-bariatric reconstruction.PRE-REGISTRATION: Clinicaltrials.gov NCT07059104.}, issn = {1748-6815} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonbjrn_2025, title = {Friendsrapporten 2025. Trygghet, tillit och tillhörighet : En rapport om våldet i skolan. Och lösningarna som faktiskt fungerar}, author = {Johansson, Björn and Bergquist, Lisen and Christiansson, Ylva and Forsbeck, Björn and Loftsson, Magnus and Warg, Frida}, year = {2025}, url = {2011925}, language = {swe}, publisher = {Stiftelsen Friends}, abstract = {Friendsrapporten 2025 bygger på en nationellt representativ undersökning som genomfördesav Novus under våren 2025. Totalt deltog 1 026 elever i åldern 9–16 år (årskurs 4–9). Deltagarna rekryterades via Novus föräldrapanel. Vårdnadshavare informerades och gav samtycke och barnet gav därefter sitt eget samtycke till att delta.Eftersom urvalet görs via föräldrar snarare änskolor ingår elever från många olika skolor. Baserat på postnummeruppgifter i materialet uppskattar vi att svaren representerar ungefär 300–500 unika skolor i landet. Det är för få elever per skola för att kunna uttala sig om enskilda skolor, men tillräckligt många för att identifiera nationella mönster och samband i barns skolmiljöer.Undersökningen genomfördes som en webbenkät. Eleverna besvarade frågor om bakgrund (bl.a. kön/könsidentitet, ålder och årskurs) och om tre typer av utsatthet i skolan: kränkningar och mobbning, trakasserier samt grovt våld. Frågorna om mobbning och trakasserier avser de senaste två månaderna, medan frågorna om grovt våld avser de senaste tolv månaderna.Vidare besvarade eleverna frågor om skolklimat, om hur elever och vuxna reagerar när någon blir illa behandlad, samt om tillgång till stöd från vänner och vuxna i skolan. Svaren har viktats för kön och ålder så att resultaten bättre speglar elevpopulationen i Sverige. Små avvikelser mellan totalsummor i tabeller och diagram kan förekomma på grund av viktning och avrundning.Detta är en tvärsnittsstudie (genomförd vid ett tillfälle). Resultaten kan därför inte tolkas som orsakssamband. För tolkning lutar vi oss mot tidigare forskning och en forskningssammanställning via Scopus om skolklimat (Bullying and school climat), elevers och vuxnas reaktioner (Bystander and teacher interventions in bullying), samt socialt stöd (Social support for bullying prevention). När denna forskning visar samma mönster som våra resultat bedömer vi att slutsatserna är giltiga för Sverige 2025. Svaren har hanterats konfidentiellt och analyserats i avidentifierad form.}, file = {https://oru.diva-portal.org/smash/get/diva2:2011925/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lidskogrolf_2025_1, title = {From climate facts to climate risks : How the IPCC treats risk and uncertainty}, author = {Lidskog, Rolf}, year = {2025}, journal = {Journal of Risk Research}, volume = {28}, number = {1}, pages = {1--16}, doi = {10.1080/13669877.2025.2488392}, url = {1951676}, language = {eng}, publisher = {Routledge}, keywords = {boundary object; climate change; ipcc; risk; uncertainty}, abstract = {This paper analyzes how the IPCC understands and addresses with risk and uncertainty. First, it discusses the IPCC’s formal and explicit view on how it understands, manages, and communicates risk and uncertainty in its knowledge assessments. This is done through an analysis of the documents that the IPCC has produced on the subject. The analysis reveals that the IPCC has an ambitious yet complicated system for identifying, assessing, and managing risk and uncertainty. The paper then explores how IPCC experts – researchers appointed by the IPCC to conduct its knowledge assessments – view this system and use it to determine risk and uncertainty. This is done through an interview study with IPCC experts. The analysis indicates that there are tensions in the way knowledge, uncertainty, and risk are viewed. Interviewees made limited reference to the IPCC’s formalized view of risk and uncertainty, but based on the little they did say, it appears to help them manage not only risk and uncertainty, but also internal disagreements and divergent research traditions. Finally, the paper draws conclusions about the challenges that the IPCC will face and need to address regarding risk and uncertainty.}, issn = {1366-9877}, file = {https://oru.diva-portal.org/smash/get/diva2:1951676/FULLTEXT02.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sagerforssusanna_2025, title = {From colonizer to culprit : genomic and clinical insights into S. epidermidis from post-surgical endophthalmitis}, author = {Sagerfors, Susanna and Escobar-Herrera, Leandro Andrés and Johannesen, Thor Bech and Stegger, Marc and Söderquist, Bo}, year = {2025}, journal = {European Journal of Clinical Microbiology and Infectious Diseases}, volume = {44}, number = {10}, pages = {2409--2420}, doi = {10.1007/s10096-025-05206-5}, url = {1982384}, language = {eng}, publisher = {Springer}, keywords = {staphylococcus epidermidis; antibiotic resistance; endophthalmitis}, abstract = {PURPOSE: To describe the clinical characteristics of exogenous episodes of endophthalmitis from which Staphylococcus epidermidis was isolated by vitreous cultures. We also explored the genomic traits of these S. epidermidis isolates and their relatedness to S. epidermidis originating from carriers and from prosthetic joint infections in the same geographical region.METHODS: S. epidermidis isolated from cases of exogenous endophthalmitis (n = 33) were genome sequenced. Clinical features were retrospectively collected from medical records. The isolates were compared with previously sequenced S. epidermidis isolates from the nares of healthy individuals (n = 151) and from prosthetic joint infections (n = 138).RESULTS: The most common ophthalmological procedure preceding the endophthalmitis was a posterior segment surgery (76%; 25/33), mainly intravitreal injection (70%; 23/33). These patients displayed a significantly shorter time to symptoms compared to those with an anterior segment surgery (median 3 vs. 9 days; p < 0.001), and significantly less phenotypic methicillin resistance (8%, n = 2/25 vs. 50%, n = 4/8; p = 0.02). Most isolates of S. epidermidis originating from endophthalmitis cases did not belong to known healthcare-associated lineages and did not cluster with isolates from prosthetic joint infections. Rather, they were more similar to isolates from the nares of healthy individuals.CONCLUSIONS: Genomic data suggest that the S. epidermidis isolated from the vitreous of Swedish cases of postsurgical endophthalmitis may originate from the commensal flora of the individual, and not from the healthcare facilities. The type of preceding surgical procedure (anterior vs. posterior segment) may influence both symptom delay and the presence or absence of methicillin resistance.}, issn = {0934-9723} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_amourilayan_2025_2, title = {From Conditional Integration to Collective Transformation : Youth and Future of Belonging in Sweden}, author = {Amouri, Layan}, year = {2025}, pages = {33--54}, doi = {10.4324/9781003628354-4}, url = {2019481}, language = {eng}, publisher = {Routledge} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_ohaganlaurenalex_2025_2, title = {From Foods to Nutrients : 150 Years of Modern Nutrition Science}, author = {O’Hagan, Lauren Alex and Eriksson, Göran}, year = {2025}, pages = {19--37}, doi = {10.4324/9781003450276-2}, url = {1927410}, language = {eng}, publisher = {Routledge}, abstract = {In this chapter, we present a brief overview of major developments in the field of nutrition science over the past 150 years as a means of contextualising the 13 core chapters that make up Food Marketing and Selling Healthy Lifestyles with Science. Demonstrating how understandings around what we eat and how it affects our bodies have evolved from the late nineteenth century to modern day provides a framework for much of the discussion that follows in terms of how scientific claims are used in food marketing. Across the volume, we see how food advertisements are reflective not only of the social and cultural zeitgeist but are also strongly linked to nutritional and dietetic understanding. We begin this chapter by briefly exploring the concept of nutrition in the Ancient World and throughout the centuries that followed until the Chemical Revolution of the late 1700s when the foundations were laid for modern nutrition science. Our focus then shifts to key nutritional research conducted throughout the nineteenth and early twentieth centuries, which ultimately led to the identification of individual micronutrients. Finally, we outline how the now well-established field of nutrition science has continued to develop over the past century and the state of the research area today. } } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_gugliermosimona_2025, title = {From Logs to Logic : Learning and Evaluating Interpretable Representations of Behavior for Autonomous Systems}, author = {Gugliermo, Simona}, year = {2025}, url = {2002914}, language = {eng}, publisher = {Örebro University}, abstract = {Autonomous systems are increasingly being deployed across various real-world domains, such as fleets of self-driving vehicles, robotic warehouses, and delivery services using unmanned aerial vehicles. These systems are required to operate with high reliability and predictability, to adapt continuously to changing conditions, and to remain accountable to human supervisors. To achieve these objectives, autonomous systems need explicit, formal representations of their behavior that facilitate task planning, system verification, and human oversight.In current industrial practice, such representations, whether for task-level control or action planning, are typically engineered manually. While handcrafted representations can be precise, their development is labor-intensive and difficult to scale. Learning-based approaches offer a promising alternative by extracting behavioral representations from execution data. However, they often make unrealistic assumptions, such as access to simulated environments or large volumes of high-quality training data. Moreover, they fail to simultaneously achieve all the three critical objectives, that is reliability, adaptability, and interpretability. Therefore, there is a clear need for methods capable of efficiently learning accurate, interpretable representations under realistic conditions.In this thesis, we address the problem of learning interpretable representations of system behavior from execution traces - sequences of observed actions and state transitions generated during the operation of autonomous systems. Learning from such traces is appealing because they are readily available from system logs and provide direct evidence of how a system behaves in realistic, often complex environments. The overarching goal is to derive representations that not only support automated planning but also enhance human understanding and oversight.Two distinct types of behavior representation are explored: Behavior Trees (BTs) and STRIPS-style planning domains. For each, a novel method to automatically construct representations from execution traces is proposed. Specifically, for BTs, we introduce a method that combines Boolean logic, leveraging algorithms originally developed in circuit theory, with decision tree learning to induce structured, interpretable behavior representations. To assess the interpretability of BTs, a user study is conducted to examine how such representation sare perceived by human users. The study identifies key features that influence user comprehension, contributing empirical evidence to a space that has traditionally lacked systematic analysis. Furthermore, a structured evaluation method for BTs along with quality metrics and design principles is presented, addressing the current lack of guidance for assessing BT quality beyond functional performance.For STRIPS-style domains, we introduce a novel learning framework to construct symbolic action representations directly from execution traces, even in the presence of noise. In addition to the learning algorithm, a systematic methodology is proposed for evaluating learned planning domains through structural and task-based analysis, thereby addressing a critical gap in current practice and thus responding to the growing need for rigorous assessment methods.The results demonstrate that it is possible to extract interpretable representations of autonomous behavior from noisy data. The proposed methods enable the transition from raw execution traces to structured representations that can support planning, validation, and human-in-the-loop systems. By advancing methods for learning, interpreting, and evaluating learned behavior representations, this work contributes to the development of autonomous systems that are both operationally effective and intelligible to human stakeholders.}, file = {https://oru.diva-portal.org/smash/get/diva2:2002914/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_elvnmaria_2025, title = {From passenger to driver : an interview study on person-centeredness in clinical reasoning during stroke rehabilitation}, author = {Elvén, Maria and Holmström, Inger K. and Edelbring, Samuel}, year = {2025}, journal = {European Journal of Physiotherapy}, volume = {27}, number = {5}, pages = {284--292}, doi = {10.1080/21679169.2024.2415576}, url = {1908639}, language = {eng}, publisher = {Taylor & Francis}, keywords = {clinical reasoning; decision-making; participation; person-centered care; stroke care; stroke rehabilitation}, abstract = {Purpose: To explore how stroke survivors experience and prefer to participate in clinical reasoning processes in the subacute phase of stroke rehabilitation.Methods: An explorative qualitative design was used. Individual interviews were conducted with 10 stroke survivors (4 women and 6 men, mean age 68 years) 4 weeks after their stroke, and follow-up interviews were conducted with 6 of them after 10 weeks. The interview settings were the patient's home during their home rehabilitation, an inpatient and an outpatient rehabilitation unit. A reflexive thematic analysis was performed.Results: Four themes were identified: discharge as a critical point for participation, describing a stressful time with varying involvement; supportive actions and context as crucial for participation, describing collaboration with the stroke team, the team's consideration of the stroke survivor's resources and needs, and a supportive home environment; the importance of goals and follow-up, describing goals as motivational and an unstructured use of goals; and difficulties in participation, describing a lack of dialogue with the stroke team and undetected resources and needs.Conclusions: The stroke survivors experienced changes in their participation in the clinical reasoning process as their rehabilitation progressed. They moved from perceiving themselves as passengers at the time of their hospital discharge to gradually seeing themselves as the driver of their rehabilitation process. Some person-centered attributes, such as respectful relationships and a health focus, were incorporated into the clinical reasoning, while others, such as a holistic view and shared goal-setting, required further emphasis for improved person-centeredness in stroke rehabilitation.}, issn = {2167-9169} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_lidskogrolf_2025_2, title = {From product to process : Science and the making of international environmental governance}, author = {Lidskog, Rolf and Sundqvist, Göran}, year = {2025}, pages = {268--283}, url = {2027956}, language = {eng}, publisher = {Oxford University Press}, keywords = {science-policy relations; expertise; ipcc; sts (science and technology studies); stage management; climate change; linear model of knowledge; policy relevance}, abstract = {Despite the enormous growth of scientific data on the environmental impact of human activities and ambitious efforts to synthesise and communicate this knowledge to policymakers, expert advice has not resulted in sufficient societal action. This raises the issue of science-policy relations and there are reasons to ask if and how science matters in international negotiations and political decision-making. This chapter responds to this question and explores how science works in practice when trying to influence policymaking, and also suggests how science can become more policy-relevant. Drawing on the academic fields of Science and Technology Studies (STS) and International Relations (IR), it shows how scientific knowledge can be made more relevant for policy and practice by a shift from focusing on scientific results (products) to the processes of making these results reliable and also useable. The chapter explicates this practice-oriented view by analysing the IPCC’s work and finds that it does not take the opportunity to utilize its manifold of connections to political actors in order to support and better influence the  political work to achieve the targets of the Paris Agreement. Instead these political processes and connections are hidden backstage while presenting at frontstage a seemingly autonomous and policy neutral  science in the form of assessment reports (products). } } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_demydyukganna_2025_4, title = {From Satisfaction to Loyalty : Using Machine Learning to Guide Strategic Experiencescape Investments in Upscale Hotels}, author = {Demydyuk, Ganna and Singh Kaurav, Rahul Pratap and Hilding, Anton and Mell, Joel and Carlbäck, Mats}, year = {2025}, url = {1989575}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_aretzj_2025, title = {From Strong to Weak Correlations in Breathing-Mode Kagome van der Waals Materials : Nb3(F, Cl, Br, I)8 as a Robust and Versatile Platform for Many-Body Engineering}, author = {Aretz, J. and Grytsiuk, S. and Liu, X. and Feraco, G. and Knekna, C. and Waseem, M. and Dan, Z. and Bianchi, M. and Hofmann, P. and Ali, M.N. and Katsnelson, M.I. and Grubišić-Čabo, A. and Strand, Hugo and Van, Loon E.G.C.P. and Rösner, M.}, year = {2025}, journal = {Physical Review X}, volume = {15}, number = {4}, doi = {10.1103/wr7w-nfhg}, url = {2028222}, language = {eng}, publisher = {American Physical Society}, abstract = {By combining ab initio downfolding with cluster dynamical mean-field theory, we study the degree of correlations in monolayer, bilayer, and bulk breathing-mode kagome van der Waals materials Nb3(F, Cl, Br, I)8. Our new material-specific many-body model library shows that in low-temperature bulk structures the Coulomb correlation strength steadily increases from I to Br, Cl, and F, allowing us to identify Nb3I8 as a weakly correlated insulator whose gap is only mildly affected by the local Coulomb interaction. Nb3Br8 and Nb3Cl8 are strongly correlated insulators, whose gaps are significantly influenced by Coulomb-induced vertex corrections. Nb3F8 is a prototypical bulk Mott insulator whose gap is initially opened by strong correlation effects. Angle-resolved photoemission spectroscopy measurements comparing Nb3Br8 and Nb3I8 allow us to experimentally confirm these findings by revealing spectroscopic footprints of the degree of correlation. Our calculations further uncover how the thickness and the stacking affect the degree of correlations and predict that the entire material family can be tuned into correlated charge transfer or Mott-insulating phases upon electron or hole doping. Our magnetic property analysis based on our model parameter library additionally confirms that interlayer magnetic interactions likely drive the lattice phase transition to the low-temperature structures. The accompanying bilayer hybridization through interlayer dimerization yields magnetic singlet-like ground states in the Cl, Br, and I compounds. We further prove that all low-temperature compounds are dynamically stable and that electron-phonon coupling to the low-energy subspace is suppressed. Our findings establish Nb3X8 as a robust, versatile, and tunable class for van der Waals-based Coulomb and Mott engineering with a rich phase diagram and allow us to speculate on the symmetry-breaking effects necessary for the recently observed Josephson diode effect in NbSe2/Nb3Br8/NbSe2 heterostructures. } } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_bageriushenric_2025_1, title = {Från skicklig till excellent – lärarkvaliteter i en pedagogisk meriteringsmodell}, author = {Bagerius, Henric and Borgström, Eric and Ewins, Kristin}, year = {2025}, pages = {43--55}, url = {2026856}, language = {swe}, publisher = {Mälardalens universitet}, abstract = {Det här kapitlet tar sin utgångspunkt i Örebro universitets pedagogiska meriterings-modell och undersöker hur lärares uppfattningar om pedagogisk skicklighet förhåller sig till universitetets fyra kriterier för excellent lärarskap: undervisningsskicklighet, pedagogisk reflektionsförmåga, pedagogiskt ledarskap och vetenskapligt förhållningssätt. Drygt sjuttio lärare, två från varje huvudområde vid Örebro universitet, har i en enkät fått besvara frågor om vad pedagogisk skicklighet betyder för dem. När svaren sätts i relation till kriterierna för excellent lärarskap blir det tydligt att den pedagogiska meriteringsmodellen innehåller lärarkvaliteter som det stora flertalet lärare som besvarat enkäten inte uppfattar som viktiga delar av pedagogisk skicklighet. Att gå från skicklig till excellent kan på så vis bli en utmaning för en del lärare, och i kapitlet diskuteras avslutningsvis vad pedagogiska utvecklare kan göra för att vägen ska uppfattas som framkomlig av så många lärare som möjligt.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_garcacampalara_2025, title = {Functional analyses revealed Pinus radiata CHLOROPLAST SENSOR KINASE as a key component in UV-B stress and development}, author = {García Campa, Lara and Pascual, Jesús and Meijón, Mónica and Guerrero, Sara and Morales, David and Álvarez, José M. and Valledor, Luis}, year = {2025}, journal = {Plant Stress}, volume = {15}, doi = {10.1016/j.stress.2025.100796}, url = {1947905}, language = {eng}, publisher = {Elsevier}, keywords = {uv-b stress tolerance; chloroplast signaling; plant growth; forest productivity; chloroplast sensor kinase}, abstract = {Deciphering pine response mechanisms to UV-B stress enhanced by climate change is crucial to establish damage- reducing strategies and avoid losses for forestry sector. In this study, CHLOROPLAST SENSOR KINASE from Pinus radiata (PrCSK), previously identified as a potentially relevant component in UV-B stress response using a systems biology approach, was sequenced and used to generate overexpression and RNAi Arabidopsis thaliana lines to carry out functional validation studies employing phenotypical, physiological, and metabolomic analyses. Results demonstrated CSK evolutionary conservation between A. thaliana and P. radiata and its involvement in growth, development, and UV-B response and tolerance. Notably, overexpression lines showed enhanced growth, photosynthetic performance, and stress resilience linked to efficient water and carbon use, as well as resilient and efficient carbohydrate metabolism. Conversely, amino acid metabolism was essential for plant recovery when cellular damage increased due to CSK down-regulation, which also resulted in severe growth retardation. Moreover, secondary metabolism, represented by the accumulation of phenolic compounds, was also modified according to CSK expression levels. Overall, these results propose PrCSK as a valuable biomarker to select tolerant trees to adverse UV-B environmental conditions expected in the coming years, and to increase pine biomass and production to meet current and future global demand of timber products.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bezabheyared_2025, title = {Functional transposition of renal functions to the posterior intestine during maturation in male three-spined stickleback}, author = {Bezabhe, Yared and Paylar, Berkay and Seyoum, Asmerom and Borg, Bertil and Olsson, Per-Erik}, year = {2025}, journal = {Scientific Reports}, volume = {15}, number = {1}, doi = {10.1038/s41598-025-05513-z}, url = {1975346}, language = {eng}, publisher = {Nature Publishing Group}, keywords = {11-ketoandrostenedione; androgen; glucose; kidney; solute transporters}, abstract = {During the breeding season, the male stickleback proximal tubule of the kidney undergoes hypertrophy. This is due to the synthesis of the nest building protein spiggin, in response to increased levels of 11-ketotestosterone. The increased protein synthesis that is initiated during breeding alters the kidney function and the ability to secrete excess water, to osmoregulate, in fresh water. It has earlier been shown that there exist organ specific differences in transport proteins between mature and non-mature three-spined stickleback. To understand the molecular mechanisms compensating for kidney functions, this study examined transport genes responsible for functional changes between the kidney and intestine. RNA sequencing was performed on castrated and 11-ketoandrostenedione (11KA)-treated male stickleback. Results showed organ-specific responses: 2,549 differentially expressed genes (DEGs) in the kidney and 885 in the posterior intestine, with 210 shared between the organs. Solute transporters, aquaporin 10a and cadherin-17, were upregulated in the posterior intestine but downregulated in the kidney in 11KA treated males. Enrichment analysis revealed distinct biological processes, primarily involving solute transporters, indicating functional adaptation. While amino acid and ion transport were downregulated in the kidney, compensatory transport was observed in the posterior intestine. However, cellular hexose transporters were downregulated in both organs, suggesting a reduction in glucose absorption and passive water diffusion. The present study shows that androgens alter the expression of cellular transporters and redirect functions of the kidney to the posterior intestine. The results also indicate reduced glucose absorption in breeding, male three-spined stickleback.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mielkelouisa_2025, title = {Fungal guild interactions slow decomposition of boreal forest pine litter and humus}, author = {Mielke, Louis A. and Klein, Julian and Ekblad, Alf and Finlay, Roger D. and Lindahl, Björn D. and Clemmensen, Karina E.}, year = {2025}, journal = {New Phytologist}, volume = {247}, number = {5}, pages = {2367--2380}, doi = {10.1111/nph.70316}, url = {1976544}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {bayesian modeling; boreal forests; gadgil effect; decomposition; ectomycorrhiza; ericoid mycorrhiza; saprotrophic fungi; soil}, abstract = {Ericaceous understory shrubs and ericoid mycorrhizal fungal communities are ubiquitous in boreal forests, and their interactions with ectomycorrhizal and saprotrophic fungi may determine organic matter dynamics in forest soils. We followed decomposition of pine needle litter and mor-layer humus over 3 yr in a factorial shrub removal- and pine root exclusion experiment in an old-growth Scots pine (Pinus sylvestris) forest, to evaluate effects of fungal guilds on mass loss. Litter mass loss was 23% greater when ectomycorrhizal fungi were excluded suggesting increased saprotrophic activity, independently of ericoid shrub presence. However, this 'Gadgil effect' was only found after 17 months following a summer drought. By contrast, humus mass loss was overall stimulated by ectomycorrhizal fungi, while ericoid mycorrhizal shrubs appeared to counteract this effect, potentially caused by simultaneous addition of recalcitrant organic matter and inhibition of ectomycorrhizal decomposers. We conclude that competitive saprotrophic-ectomycorrhizal fungal interactions may slow early-stage litter decomposition, but this effect was small and inconsistent. Furthermore, interactions between ecto- and ericoid mycorrhizal guild members appear to determine the late-stage organic matter balance of boreal forest humus.}, issn = {0028-646X} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_hlnmats_2025, title = {Future EU enlargements : Opportunities and dilemmas}, author = {Öhlén, Mats}, year = {2025}, pages = {23--48}, doi = {10.1007/978-3-031-83441-7_2}, url = {1953975}, language = {eng}, publisher = {Palgrave Macmillan}, keywords = {european union; eu; enlargement; western balkans; eastern partnership}, abstract = {This chapter focuses on the EU’s future enlargement plans. In a time of war and instability, the enlargement plans have gained new momentum, and the chapter addresses the question of how the EU can (and should) manage the risks and opportunities associated with a new wave of enlargement. It first presents various incentives for an EU enlargement: economic, geopolitical and normative. It then examines the formal and informal procedures of the enlargement process, which has become increasingly lengthy and evaluative. Against this background, it provides an overview of the current enlargement processes in two distinct regions: the Western Balkans and the Eastern Partnership, followed by a discussion of the EU’s capacity to enlarge and various proposals for institutional reforms to manage a new enlargement. The chapter concludes with a comparison of the Western Balkans and the Eastern Partnership in terms of the challenges and opportunities of enlargement. It also examines the broader dilemmas that the EU is facing in this process. It concludes that the EU should first prioritise internal unity on the core issue of whether it wants to enlarge, and then show endurance and patience throughout the process.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hiyoshiayako_2025, title = {Future sick leave, disability pension, and unemployment among patients with cancer after returning to work : Swedish register-based matched prospective cohort study}, author = {Hiyoshi, Ayako and Alexanderson, Kristina and Tinghög, Petter and Cao, Yang and Fall, Katja and Montgomery, Scott}, year = {2025}, journal = {Cancer}, volume = {131}, number = {1}, doi = {10.1002/cncr.35580}, url = {1904396}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {cancer; disability pension; return to work; sick leave; trajectory; unemployment}, abstract = {INTRODUCTION: Despite increasing numbers of working-age cancer survivors, evidence on their future work-related circumstances is limited. This study examined their future sick leave, disability pension, and unemployment benefits compared to matched cancer-free individuals.METHODS: A matched cohort study was conducted using nationwide Swedish registers. In total, 94,411 individuals aged 25 to 59 years when diagnosed with incident cancer in 2001-2012 and who returned to work after cancer were compared with their matched cancer-free individuals (N = 354,814). Follow-up started from the year before cancer diagnosis and continued up to 14 years. Generalized estimating equations were used to calculate incidence rate ratios (IRR) and odds ratios for the difference between cancer survivors and matched cancer-free individuals.RESULTS: Compared with cancer-free individuals, cancer survivors had six times higher sick-leave days per year after cancer (IRR 6.25 [95% CI, 5.97-6.54] for men; IRR, 5.51 [5.39-5.64] for women). This higher number of sick-leave days declined over time but a two-fold difference persisted. An approximate 1.5 times higher risk of receiving disability pension remained during follow-up. The unemployment days tended to be lower for cancer survivors (IRR, 0.84 [0.75-0.94] for men; IRR, 0.91 [0.86-0.96] for women). Risk of sick leave and disability pension was higher among those with leukemia, colorectal, and breast cancer than skin and genitourinary cancers.CONCLUSIONS: Cancer survivors who returned to work experienced a high and persisting sick leave and disability pension for over a decade. Prolonged receipt of a high amount of benefits may have long-term adverse impacts on financial circumstances; more knowledge to promote the environment that encourages returning to and remaining in work is needed.}, issn = {0008-543X} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_goncalvesricardo_2025, title = {Fysisk beröring som en omsorgsfull pedagogisk handling i förskolan}, author = {Goncalves, Ricardo}, year = {2025}, pages = {199--216}, url = {1988155}, language = {swe}, publisher = {Natur och kultur} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_9, title = {Förenligt med EU-rätten att neka skattskyldig rätt att återfå felaktigt inbetald mervärdesskatt från säljaren – analys}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031839}, language = {swe}, publisher = {JP Infonet}, keywords = {mervärdesskatt; moms}, abstract = {Den 13 mars 2025 meddelade EU-domstolen en dom som avser situationen när det har blivit materiellt omöjligt att erhålla återbetalning av den mervärdesskatt som bolaget felaktigt fakturerades av säljaren och som säljaren därefter betalade in till statskassan. Frågan avser bland annat effektivitetsprincipens genomslag. JP Infonets expert professor Eleonor Kristoffersson analyserar domen. } } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_10, title = {Förhandsbesked i mål om mervärdesskatt undanröjt av HFD}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031707}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 4 april 2025 meddelade Högsta förvaltningsdomstolen ett beslut om att avvisa en talan om överklagande av ett förhandsbesked från Skatterättsnämnden avseende frivillig beskattning för mervärdesskatt samt att undanröja förhandsbeskedet (mål nr 6151–24). Eleonor Kristoffersson, professor i skatterätt, analyserar beslutet.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_11, title = {Förhandsbesked om anställdas förvärv av optioner}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031697}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 23 januari 2025 meddelade Skatterättsnämnden ett förhandsbesked om beskattningstidpunkten för anställdas förvärv av optioner (diarienummer 52-24/D) Eleonor Kristoffersson, professor i skatterätt, analyserar förhandsbeskedet.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_12, title = {Förhandsbesked om expertskatt}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031692}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 19 maj 2025 kom Skatterättsnämdens förhandbesked i ärdende 96/24-D om expertskatt. Eleonor Kristoffersson, professor i skatterätt, analyserar förhandsbeskedet.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_13, title = {Förhandsbesked om överlåtelse av tillgångar}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031695}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 28 januari 2025 meddelade Skatterättsnämnden förhandsbesked om verksamhetsöverlåtelse enligt 5 kap. 38 § mervärdesskattelagen (2023:200), ML (diarienummer 76-24/I). Eleonor Kristoffersson, professor i skatterätt, analyserar förhandsbeskedet.} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_dahlizabelaa_2025_1, title = {Förintelsen & Sverige : tiden före, under, efter}, author = {Dahl, Izabela A. and Kvist Geverts, Karin}, year = {2025}, url = {1953741}, language = {swe}, publisher = {Natur och kultur}, keywords = {förintelsen; sverige; lärobok}, abstract = {I en tid när Förintelsens överlevande som tidsvittnen försvinner spelar minnet av Förintelsen en central roll för vår kunskap om det förflutna. Med tiden blir den en del av vårt kollektiva minne, och det som de överlevande som kom till Sverige lämnade efter sig blir en del av svensk historia.Förintelsen & Sverige är en antologi som belyser tiden före, under och efter Förintelsen. De olika kunskaper och perspektiv som lyfts fram ger inblick i den rika kultur som raderades, hur majoritetssamhällena agerade, vad förövarna strävade efter samt vad hjälpinsatser och motstånd åstadkom. Genom nedslag bland alla aktörer – från offer, åskådare och förövare till dagens efterlevande och förnekare – får historien nyanser och kan studeras bättre. Med ett fokus på tiden efter ges verktyg för att förstå hur trauman bärs vidare i generationer och hur minnen kan representeras.Boken riktar sig till lärarstudenter, yrkesverksamma lärare och en intresserad allmänhet som vill öka sina kunskaper om Förintelsen generellt men också specifikt i relation till Sverige.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_jonssonjessica_2025_2, title = {Förord}, author = {Jonsson, Jessica}, year = {2025}, pages = {7--11}, url = {1993576}, language = {swe}, publisher = {Iustus förlag}, abstract = {Juristprogrammet vid Örebro universitet firar 20 år och detta uppmärksammas med en jubileumsantologi!Under dessa två decennier har programmet utvecklats till en dynamisk och betydelsefull utbildningsmiljö, präglad av engagerade lärare, nyfikna och kritiskt tänkande studenter samt ett omgivande samhälle i ständig förändring. Antologin speglar programmets resa, från de ursprungliga idéerna och visionerna till dagens framstående utbildning, med rötterna djupt förankrade i rättsvetenskapen och blicken riktad mot framtidens utmaningar.Titeln Lagar och vägar symboliserar både de stabila fundament som juridiken vilar på och de nya stigar som ständigt öppnas när samhället förändras. Rättsvetenskapen är en hörnsten i universitetets verksamhet och spelar en avgörande roll i samhällsutvecklingen genom att analysera, problematisera och kritiskt granska rättsregler, rättspraxis och rättsliga principer. Som akademisk disciplin står den för kunskap, analys och reflektion – egenskaper som är centrala för såväl forskning som utbildning.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_wistrandsten_2025, title = {Förord}, author = {Wistrand, Sten}, year = {2025}, pages = {9--28}, url = {2022702}, language = {swe}, publisher = {Hastur förlag}, keywords = {nathaniel hawthorne; fantastik; amerikansk 1800-talslitteratur} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_6, title = {Försvara demokratin där du står! : En recension av Angreppet. Så urholkar Tidöregeringen vår demokrati}, author = {Johansson Wilén, Evelina}, year = {2025}, journal = {Röda rummet}, number = {1}, pages = {48--49}, url = {1978731}, language = {swe}, publisher = {Socialistiska partiet}, issn = {1403-3844} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_strandbergthomas_2025, title = {Förvärvad hjärnskada - omställning, psykisk ohälsa och vardagsliv}, author = {Strandberg, Thomas}, year = {2025}, journal = {Hjärnkraft}, number = {2}, pages = {16--18}, url = {2026171}, language = {swe}, publisher = {Hjärnskadeförbundet Hjärnkraft}, abstract = {Vad säger forskningen om förvärvad hjärnskada och psykisk ohälsa? Här redogör professor Thomas Strandberg för forskningsläget utifrån svensk och internationell forskning. Han poängterar vikten av att vårdpersonal är uppmärksam på tecken på psykisk ohälsa och erbjuder adekvat stöd.}, issn = {1654-7446} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_magnussonsporrececilia_2025, title = {Gastronomic Variables : A Framework for Design and Quality Assurance of Food Dishes, Meals, and Menus}, author = {Magnusson Sporre, Cecilia and Wennström, Stefan and Wellton, Lotte}, year = {2025}, journal = {Journal of Culinary Science & Technology}, doi = {10.1080/15428052.2025.2550432}, url = {1992782}, language = {eng}, publisher = {Taylor & Francis}, keywords = {culinary arts education; menu planning; cooking craft; taste; food design}, abstract = {The serving of meals in professional contexts is a complex task. To succeed, the critical elements of planning and service should be carefully considered. Few, useful tools exist for designing and assessing dishes, meals, and menus. This article introduces the framework of gastronomic variables, developed over 20 years of pedagogical and didactical practices, as a qualitative tool in designing meals. The framework comprises seven gastronomic variables: taste and flavour, aroma, temperature, texture, colour, shape, quantity/volume. The framework helps students and professionals to focus on critical components in the design of dishes and is also useful for assessment in education.}, issn = {1542-8052} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_rppeljensvolker_2025, title = {Gaze-supported Large Language Model Framework for Bi-directional Human-Robot Interaction}, author = {Rüppel, Jens Volker and Rudenko, Andrey and Schreiter, Tim and Magnusson, Martin and Lilienthal, Achim}, year = {2025}, pages = {677--684}, doi = {10.1109/RO-MAN63969.2025.11217612}, url = {2026858}, language = {eng}, keywords = {multimodal interaction and conversational skills; cooperation and collaboration in human-robot teams; non-verbal cues and expressiveness}, abstract = {The rapid development of Large Language Models (LLMs) creates an exciting potential for flexible, general knowledge-driven Human-Robot Interaction (HRI) systems for assistive robots. Existing HRI systems demonstrate great progress in interpreting and following user instructions, action generation, and robot task solving. On the other hand, bi-directional, multimodal, and context-aware support of the user in collaborative tasks still remains an open challenge. In this paper, we present a gaze- and speech-informed interface to the assistive robot, which is able to perceive the working environment from multiple vision inputs and support the dynamic user in their tasks. Our system is designed to be modular and transferable to adapt to diverse tasks and robots, and it is real-time capable due to the language-based interaction state representation and fast on-board perception modules. Its development was supported by multiple public dissemination events, contributing important considerations for improved robustness and user experience. Furthermore, in a lab study, we compare the performance and user ratings of our system with those of a traditional scripted HRI pipeline. Our findings indicate that an LLM-based approach enhances adaptability and marginally improves user engagement and task execution metrics but may produce redundant output, while a scripted pipeline is well suited for more straightforward tasks. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_deboisesam_2025, title = {Gender disparities in music education and music-making amongst the Swedish adult population}, author = {de Boise, Sam}, year = {2025}, journal = {Nordic Research in Music Education}, volume = {6}, pages = {1--27}, doi = {10.23865/nrme.v6.6709}, url = {1933012}, language = {eng}, keywords = {equality; inequity; music-making; music-participation; cultural democracy}, abstract = {This article explores the extent of gender disparities in: (a) formal non-compulsory music education (FNCME), (b) instrument uptake, choice and continuation, and (c) music composition and production within the Swedish adult population. A nationally representative online survey of 1096 respondents aged 18–79 years old was conducted in 2023 and analysed using chi-squared tests and binary logistic regression. Data indicated that gender was the main factor impacting on all three aspects, intersecting significantly with age. This was even when accounting for highest level of educational attainment, employment type, personal income, region and whether respondents were born in Sweden.}, file = {https://oru.diva-portal.org/smash/get/diva2:1933012/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_janssonmaria_2025, title = {Gender equality and diversity discourses intertwined with the implementation of the EU audiovisual media services directive in Lithuania, Spain, and Sweden}, author = {Jansson, Maria and Calderón-Sandoval, Orianna and Oral, Taisija}, year = {2025}, journal = {The International Journal of Cultural Policy}, pages = {1--23}, doi = {10.1080/10286632.2025.2593352}, url = {2016519}, language = {eng}, publisher = {Taylor & Francis}, keywords = {diversity; streaming services; comparative; eu media policy; gender equality}, abstract = {In the face of recent challenges to gender equality and diversity, most European countries feature such policies in their support schemes for film production and in regulation of public service television. Moreover, global streaming platforms such as Netflix have made inclusion policies part of their brand. In an effort to unpack how EU-policies are intertwined with inclusion efforts, this article investigates gender equality and diversity discourses in the implementation of the 2018 EU Audiovisual Media Services Directive in Lithuania, Spain, and Sweden. The article uses a discourse policy analysis to compare problem representations and to understand how the articulation of the implementation of the Directive have continued, challenged or been intertwined with different discourses. The article finds that in Spain the Directive continued a discourse on gender equality and diversity, while in Lithuania and Sweden, the implementation of the Directive was intertwined with discourses seeking to limit or roll back gender equality and diversity.}, issn = {1028-6632} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_7, title = {Gender knowledge production and epistemology in the incelosphere}, author = {Johansson Wilén, Evelina and Wemrell, Maria and Gunnarsson, Lena}, year = {2025}, pages = {18--18}, url = {1978726}, language = {eng}, abstract = {There is a growing field of research dedicated to online incel communities, gathering men identifying as involuntary celibates or ‘incels’. A distinctive aspect of the incelosphere is the elaborate ‘theoretical framework’ communicated in the forums, portraying incel men as voiceless losers at a (hetero)sexual market ruled by women and biologically superior men. While the content of this incel worldview is relatively well-studied, a notable gap exists in the examination of the way knowledge production taking place within these communities is epistemologically legitimized. This article aims to fill this void by scrutinizing the epistemic logics and practices used by members at incel forums to validate their knowledge production on gender relations. By shedding light on how incels mobilize science as well as counter-hegemonic forms of knowledge production to legitimize their knowledge claims, the article offers a nuanced understanding of the intricate relation between the knowledge production of movements and counter-movements. This exploration can, we believe, form a basis for challenging and contesting claims made by incels.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_matrnemarie_2025, title = {Gender matters : factors important for quality of life in midlife after stroke}, author = {Matérne, Marie and Jarl, Gustav and Simpson, Grahame and Appelros, Peter and Thermaenius, Ingrid and Arvidsson Lindvall, Mialinn}, year = {2025}, journal = {Frontiers in Neurology}, volume = {16}, doi = {10.3389/fneur.2025.1590900}, url = {2000193}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {gender; lifespan development; mid-life; quality of life; stroke}, abstract = {BACKGROUND: Coping with disabilities after stroke in midlife can be challenging, with potential gender differences that may have implications for quality of life (QoL) and support. This study aimed to explore QoL and resilience among midlife stroke survivors from a gender perspective.METHODS: Quantitative questionnaire data related to demographics, function, service, resilience and QoL were gathered from a stroke register including 51 individuals (of whom 29 were men) aged 40-64 years. Results of gender were compared using two-sided t-tests and chi-square tests. Additionally, eight semi-structured telephone interviews were conducted, with equal representation of men and women. Qualitative content analysis was used to explore deeper and capture nuanced insights.RESULTS: The quantitative analysis revealed no statistically significant gender differences. However, the qualitative data revealed three central themes: (1) "A Forced Lifestyle Change," (2) "Lack of Understanding and Support," and (3) "Importance of Independence and Coping Strategies." Men talked about feelings of being restricted in their post-stroke lives and expressed a greater need for support from healthcare providers, family, and friends. In contrast, women described having more well-developed coping strategies and reported a higher perceived QoL.CONCLUSION: Qualitative findings suggest men may face greater challenges in adapting to post stroke life. The result suggests that men struggle with accepting limitations that prevent them from participating in social contexts and require more support from healthcare services. These difficulties, potentially due to less effective coping mechanisms, may result in a lower QoL. Gender-sensitive interventions addressing these needs could improve QoL and adaptation.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_birhanubetelbekele_2025, title = {Gender Parity Reform as Autocratic Genderwashing? Analyzing Ethiopia's Post-Protest Experiment}, author = {Birhanu, Betel Bekele and Lemma, Hanna and Strid, Sofia}, year = {2025}, journal = {Social Politics: International Studies in Gender, State and Society}, volume = {32}, number = {4}, pages = {1232--1255}, doi = {10.1093/sp/jxaf041}, url = {2002881}, language = {eng}, publisher = {Oxford University Press}, keywords = {autocratic genderwashing; ethiopia; gender parity reform; women's cabinet representation in africa; unintended outcomes}, abstract = {One of the reform initiatives following the 2018 protest-induced political change in Ethiopia was the introduction of a gender parity cabinet and the appointment of women to some of the highest offices, including the presidency. This article asks: does this reform reflect an "autocratic genderwashing"? How has its implementation evolved, especially amid conflict, and what are its broader implications for gender equality? Based on interviews with key informants and an online public survey, our results caution against viewing autocratic genderwashing solely as pejorative, highlight the importance of legal requirements for gender parity in appointed positions, and underscore the need for democratic dispensation, particularly considering the significant challenges women in politics face in non-democratic settings.}, issn = {1072-4745} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_husuliisa_2025, title = {Gender Research and Gender Studies in the Nordic Region of Europe}, author = {Husu, Liisa and Grönroos, Maria}, year = {2025}, doi = {10.1007/978-3-658-12500-4_150-2}, url = {2029570}, language = {eng}, publisher = {Springer}, keywords = {nordic countries; gender research; gender equality; universities; feminism; norden; genusvetenskap; genusforskning; jämställdhet; universitet}, abstract = {The five Nordic countries are rated as the most gender equal societies worldwide. Given this context, this article discusses the advances and challenges of addressing or integrating gender as a dimension in mainstream disciplines, and the development of a discipline of its own, from the 1970s to present.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_axelssontobiask_2025, title = {Gender theory approaches to fathers' parental leave experiences of primary childcare : a review of Nordic publications 1992–2020}, author = {Axelsson, Tobias K.}, year = {2025}, journal = {Norma}, volume = {20}, number = {2}, pages = {158--175}, doi = {10.1080/18902138.2025.2455890}, url = {1931747}, language = {eng}, publisher = {Routledge}, keywords = {parental leave; fathers; primary caregivers; childcare; nordic; critical studies on men and masculinities}, abstract = {Since the 1990s, fathers’ use of parental leave has become commonplace, normalised, and expected, especially in the Nordic countries, which were the first to introduce earmarked periods of paid leave for fathers. This development has given rise to a research field that is explored and conceptualised in this systematic literature review as gender research on fathers’ parental leave experiences of primary childcare. The aim is to identify and critically discuss salient gender theory approaches within this research field. The materials comprise 26 publications analysed using a thematic and retroductive method. Three salient gender theory approaches are identified and discussed: ‘the empirically situated gender theory approach,’ ‘the multilevel gender theory approach,’ and ‘the masculinity theory approach.’ To avoid theoretical homogenisation and a reified understanding of the notion of masculinities, I suggest that emerging gender theory approaches in the field of gender research on fathers’ parental leave experiences need to be developed – in dialogue with feminist fatherhood research, CSMM, and childhood studies. Firstly, there is a need to theorise themes positioned as empirical ‘findings’. Secondly, a deliberate child perspective is needed. Finally, gender theory approaches need to overcome the ‘either/or’ situation, in which the analyses are either empirically grounded or theoretically informed.}, issn = {1890-2138} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stridsofia_2025, title = {Gender-based violence in academic and research workplaces : Pervasiveness in higher education and research performing organisations}, author = {Strid, Sofia and Hearn, Jeff}, year = {2025}, journal = {Socialmedicinsk Tidskrift}, volume = {102}, number = {1}, pages = {112--123}, doi = {10.62607/smt.v102i1.24856}, url = {1958420}, language = {eng}, publisher = {Stiftelsen Socialmedicinsk tidskrift}, keywords = {violence; harassment; universities; research; higher education; akademin; genusbaserat våld; prevalens; universitet; våld}, abstract = {Gender-based violence (GBV) at work or study place often falls outside of the mainstream violence research interests. However, it is now well established that violence is far from rare in work and workplaces, in organisations, and for certain occupations. This is all the more so when violence is understood in a broad sense to include harassment, bullying, psychological violence, and further violations, as in feminist conceptualisations of GBV. In this paper, we address GBV in a particular arena which, it would be hoped, would be designed to enhance well-being, safety, knowledge and education: namely, higher education (HE) and research performing organisations (RPOs). Importantly, from our perspective, HE and RPOs are not only educational and research sites, but also need to be understood as work, workplace, employment, occupational, organisational, professional and managerial sites. We draw on recent research within the EU funded UniSAFE, a large multi-country research and innovation project on GBV in HE and RPOs. UniSAFE has aimed to provide reliable, comparable data on different forms of gender-based violence in HE and RPOs in order to understand the extent of the problem among staff and students, assess institutional responses, and develop tools to address that problem. The materials include a survey of prevalence and consequences of GBV in HEI and RPOs (n=42 000), in-depth case studies, a strategic mapping of GBV policy and measures in 46 HEI and RPOs , and a mapping of national policy on GBV in HE.;Artikeln diskuterar könsbaserat våld vid lärosäten och forskningsorganisationer (RPO) i betydelsen arbetsplatser, sysselsättning, yrkes-, organisations-, och ledningsplatser. Datan baseras på det EU-finansierade UniSAFE och inkluderar en onlineenkät om förekomst och konsekvenser av könsbaserat våld (n=42 000), en kartläggning av nationell policy om könsbaserat våld inom högre utbildning och forskningsorganisationer, samt institutionella policyer och åtgärder för att motverka könsbaserat våld i 46 forskningsorganisationer i femton länder. Resultaten visar att prevalensen är mycket hög, ojämlik mellan olika grupper, men ändå relativt enhetlig mellan länder och institutioner, vilket tyder på att prevalensen av könsbaserat våld i stort sett inte är relaterad till de forskningsorganisationer där respondenterna arbetar eller studerar, och/eller till det land där de bor. Könsbaserat våld inom lärosäten och forskningsorganisationer verkar därmed ha ett eget system och en egen logik.}, issn = {0037-833X}, file = {https://oru.diva-portal.org/smash/get/diva2:1958420/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hearnjeff_2025_2, title = {Gender-based violence in higher education and research performing organisations : three steps in critique and reconceptualisation}, author = {Hearn, Jeff and Strid, Sofia and Humbert, Anne Laure and Bondestam, Fredrik and Husu, Liisa}, year = {2025}, journal = {Journal of Gender-Based Violence}, volume = {9}, number = {4}, pages = {513--535}, doi = {10.1332/23986808y2025d000000093}, url = {1998258}, language = {eng}, publisher = {Bristol University Press}, keywords = {universities; research organisations; higher education; organisational violence}, abstract = {The critique and conceptualisation of current policy and research on gender-based violence in higher education institutions (HEIs) and research performing organisations (RPOs) are matters of central importance. Building critically on recent European research and policy experience, and conceptual reflections arising from a large European multi-country research and innovation project, three key steps in critique and reconceptualising of gender-based violence in HEIs and RPOs are explicated. These are: first, clarification of differential definitions of and inclusions in gender-based violence in HEIs and RPOs; second, drawing on the recent European UniSAFE project survey and analysis of 42,000 university staff and student respondents in 46 institutions within 15 countries, differential contextualisations of prevalence and consequences, especially the need for multi-level and intersectional analysis of prevalence and consequences; and, third, engagement with ongoing theoretical and practical contestations in conceptualisation. The article concludes with discussion of further key issues for research and policy. These include how gender and gender-based violence are understood across national, organisational contexts, and the need for more focus on perpetrators, and the organisational relations between perpetrators and victims. In working towards violence-free and safe HEIs and RPOs, the connections between violence and organisational structures, processes and dynamics must be confronted proactively.}, issn = {2398-6808}, file = {https://oru.diva-portal.org/smash/get/diva2:1998258/FULLTEXT01.pdf} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_breivikmeyermarit_2025, title = {Gendering Entrepreneurial Ecosystems : Levelling the Field}, author = {Breivik-Meyer, Marit and Lindvert, Marta and Callerstig, Anne-Charlott and Balkmar, Dag and Alsos, Gry Agnete}, year = {2025}, doi = {10.4324/9781003431060}, url = {1933958}, language = {eng}, publisher = {Routledge}, keywords = {entrepreneurial ecosystems; gender; entrepreneurship; inclusion}, abstract = {The increased interest in entrepreneurial ecosystems often builds on the underlying assumption that entrepreneurs have equal access to resources, participation, and support. However, women are underrepresented in successful entrepreneurial ecosystems and a persistent gender bias continues to exist. This bias is reflected in assumptions about the typical entrepreneur. It is white American men that spring to mind, portrayed as entrepreneurial superheroes, associated with risk- taking and big money. That they are men is often taken for granted; with successful female entrepreneurs seldom elevated in the same way. This illustrates how entrepreneurship is gendered, with implications for resource access and chances of success. The entrepreneurial ecosystem is not a level playing field.This book gives insights on how to remedy gendered challenges that pose problems not only for individuals but also for the entrepreneurial ecosystem. By analysing ways of making entrepreneurial ecosystems more gender- inclusive, the chapters collectively highlight the impact of gender dynamics on entrepreneurial ecosystems and introduce innovative methods for fostering inclusivity. With examples from around the globe, they emphasise the actors and factors that matter for gender- inclusive entrepreneurial ecosystems.The book is interdisciplinary and will appeal to scholars, upper- level students and policymakers interested in entrepreneurship and gender inclusivity.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_garciaargibaymiguel_2025_1, title = {General disease factor : evidence of a unifying dimension across mental and physical illness in children and adolescents.}, author = {Garcia-Argibay, Miguel and Brandt, Valerie and Sun, Hongyi and Solmi, Marco and Lichtenstein, Paul and Larsson, Henrik and Cortese, Samuele}, year = {2025}, journal = {BMJ Mental Health}, volume = {28}, number = {1}, doi = {10.1136/bmjment-2025-301592}, url = {1965059}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {child & adolescent psychiatry}, abstract = {BACKGROUND: Understanding the relationship between mental and physical health conditions is crucial for developing comprehensive healthcare strategies. The putative existence of a general disease factor (d-factor) that underlies the vulnerability to both physical and mental conditions could have important implications for our approach to health assessment and treatment.OBJECTIVE: To investigate the presence and characteristics of a general d-factor in children and adolescents.METHODS: This Swedish registry-based cross-sectional study included children and adolescents born between 1996 and 2003 with follow-up until 2013. We extracted data on 25 mental and physical health conditions according to the ICD-10 system. To determine the optimal dimensional structure of these conditions, several competing measurement models were tested, including correlated factors, one factor, various bifactor specifications and bifactor exploratory structural equation modelling (ESEM).FINDINGS: The study cohort included 776 667 individuals (mean age 13.96 years, IQR=11.96-16.04; 51% male). The bifactor ESEM model, including a general d-factor and specific mental and physical health factors, provided the best fit to the data compared to alternative models (Comparative Fit Index=0.971, Tucker-Lewis Index=0.962, root mean square error of approximation=0.007 (0.007-0.007)). The d-factor accounted for substantial variance (ωh=0.582, explained common variance (ECV)=0.498), while specific mental (ωhs=0.377, ECV=0.373) and physical (ωhs=0.423; ECV=0.130) factors also indicated additional significant unique contributions.CONCLUSIONS: This study provided evidence for a multidimensional structure of health in children and adolescents, characterised by a general d-factor underlying both mental and physical conditions, alongside distinct domain-specific factors. These findings have important implications for clinical practice, providing evidence that suggests the need for more integrated approaches to health assessment and treatment that consider the interconnectedness of mental and physical health.}, file = {https://oru.diva-portal.org/smash/get/diva2:1965059/FULLTEXT01.pdf} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_14, title = {Generaladvokatens yttrande i Högkullen-målet}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031699}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 6 mars 2025 kom generaladvokatens yttrande i C-808/23 Högkullen. Målet avser omvärdering av beskattningsunderlaget i mervärdesskattesammanhang. Eleonor Kristoffersson, professor i skatterätt, diskuterar yttrandet.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_aregbedevictor_2025, title = {Generative to Discriminative Knowledge Distillation for Object Affordance}, author = {Aregbede, Victor and Sygkounas, Alkis and Persson, Andreas and Längkvist, Martin and Loutfi, Amy}, year = {2025}, doi = {10.1109/ICDL63968.2025.11204436}, url = {2028723}, language = {eng}, publisher = {IEEE}, abstract = {In this paper, we present a novel approach to relational object affordance learning by leveraging the knowledge distillation paradigm, where large language models (LLMs) serve as generative teacher models. Distinct from traditional affordance learning approaches, which heavily depend on manual annotations, our approach leverages LLMs to automatically generate binary affordance labels and functional rationale explanations, grounded in object semantics and physical plausibility. This reduces the need for labor-intensive labeling while harnessing the rich semantic knowledge embedded in LLMs. To transfer this knowledge, we train a discriminative student model on the generated outputs, ensuring both predictive accuracy and semantic alignment with the teacher model. The student benefits from dual supervision; affordance labels guide classification, while rationales enhance functional understanding. Experimental results demonstrate that our generative-to-discriminative distillation method improves computational efficiency while maintaining a generalizable understanding of affordances across diverse object-object-action scenarios. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_neufeldjanina_2025, title = {Genetic and environmental contributions to the link between synaesthesia and neurodevelopmental and psychiatric features : a twin study}, author = {Neufeld, Janina and van Leeuwen, Tessa M. and Kuja-Halkola, Ralf and Lundström, Sebastian and Larsson, Henrik and Lichtenstein, Paul and Bölte, Sven and Mataix-Cols, David and Taylor, Mark J.}, year = {2025}, journal = {Translational Psychiatry}, volume = {15}, number = {1}, doi = {10.1038/s41398-025-03444-x}, url = {1986137}, language = {eng}, publisher = {Springer Nature}, abstract = {Synaesthesia is a sensory phenomenon where specific inputs such as written letters or tastes automatically trigger additional sensations (for instance colours). The phenomenon is more common in people on the autism spectrum compared to the general population and seems also to be associated with other neurodevelopmental and psychiatric conditions and features. We assessed the associations between self-reported synaesthesia and eight psychiatric / neurodevelopment features in 18-year-old twins and estimated the genetic and environmental contributions to these associations using classical twin modelling. All of the neurodevelopmental / psychiatric features (related to autism, ADHD, obsessive-compulsive disorder, anxiety, depression, psychotic-like experiences, eating disorders, and (hypo-)mania) correlated positively with self-reported synaesthesia. The strongest association was found with obsessive-compulsive features (r = 0.28). Genetic factors explained more than 50% of most these associations. Environmental factors that are not shared by twins (non-shared environment) influenced the associations to different degrees, while the influence of environmental factors that are shared by twins was estimated to be negligible. Rather than being specifically linked to autism, synaesthesia seems to be associated with a wider range of neurodevelopmental / psychiatric features, and especially obsessive-compulsive features. Genetic factors play a predominant role in most of these associations, suggesting that synaesthesia might share part of its genetic causes with several neurodevelopmental / psychiatric conditions.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nguyenthuydung_2025, title = {Genetic insights into psychotic major depressive disorder : bridging the mood-psychotic disorder spectrum}, author = {Nguyen, Thuy-Dung and Meijsen, Joeri J. and Sigström, Robert and Kuja-Halkola, Ralf and Xiong, Ying and Harder, Arvid and Kowalec, Kaarina and Pasman, Joëlle A. and Scarpa, Carolina and Hörbeck, Elin and Jonsson, Lina and Hägg, Sara and Mullins, Niamh and O'Connell, Kevin S. and Dalman, Christina and Helenius, Dorte and Zetterberg, Richard and Larsson, Henrik and Lichtenstein, Paul and Andreassen, Ole A. and Werge, Thomas and Buil, Alfonso and Landén, Mikael and Sullivan, Patrick F. and Lu, Yi}, year = {2025}, journal = {EBioMedicine}, volume = {112}, doi = {10.1016/j.ebiom.2025.105576}, url = {1935529}, language = {eng}, publisher = {Elsevier}, keywords = {genetic; psychotic disorders; psychotic major depressive disorder}, abstract = {BACKGROUND: Psychotic major depressive disorder (MDD), a subtype of MDD characterised by psychotic symptoms that occur exclusively during mood episode, is clinically significant yet underexplored genetically due to its rarity. This study comprehensively examines the genetic basis of psychotic MDD and elucidates its position within the mood-psychotic spectrum.METHODS: This population-based cohort study used Swedish and Danish registry data for over 5.1 M individuals born between 1958 and 1993/1996. Specialist-diagnosed psychotic MDD was defined using ICD-10 sub-codes of MDD, F32.2/F32.3. We estimated familial aggregation/coaggregation using generalised estimating equations, heritability and genetic correlations using structural equation modelling. We also analysed ∼30,000 genotyped MDD cases from the UK Biobank and a Swedish cohort to explore which polygenic risk score (PRS) may predispose individuals to psychotic MDD.FINDINGS: With over 10,000 psychotic MDD identified from the two nationwide patient registers, this study highlights the familial aggregation of psychotic MDD, co-aggregation with mood and psychotic disorders, and its stronger genetic correlation with schizophrenia compared to non-psychotic MDD. The familial risks increased with closer biological relatedness, suggesting genetic influence. Pedigree-heritability of psychotic MDD was 30.17% (95% CI 23.53-36.80%). While the genetic correlation between psychotic and non-psychotic MDD was high (0.82, 95% CI 0.73-0.92), the psychotic subgroup showed a higher genetic correlation with schizophrenia than non-psychotic MDD (0.67 vs 0.46, p-value 7.55∗10-4). Within 30,000 genotyped MDD cases, individuals with psychotic MDD had higher mean PRS for schizophrenia and BD but a lower MDD PRS than non-psychotic MDD. PRS for BD type-I was associated with increased odds of psychotic MDD, while BD type-II PRS showed no significant association with psychotic MDD.INTERPRETATION: This study provides evidence for the genetic basis of psychotic MDD, underscoring its unique position bridging the spectrum of mood and psychotic disorders. These findings advance our understanding of the aetiology of psychotic MDD and contribute to the limited body of evidence on this phenotype by utilising large-scale population-based data.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_musaoglumiracnur_2025, title = {Genetic plasticity of the estrogen receptor and its association with depression and anxiety symptoms in young females}, author = {Musaoglu, Mirac Nur and Olofsdotter, Susanne and Vadlin, Sofia and Åslund, Cecilia and Kimmig, Ann-Christin S and Tuvblad, Catherine and Nilsson, Kent W. and Nieratschker, Vanessa and Comasco, Erika}, year = {2025}, journal = {Progress in Neuro-psychopharmacology and Biological Psychiatry}, volume = {142}, doi = {10.1016/j.pnpbp.2025.111485}, url = {1995791}, language = {eng}, publisher = {Elsevier}, keywords = {anxiety; depression; environment; estrogen receptor; gene; stress}, abstract = {Estrogens are suggested to affect mood by binding to widespread estrogen receptors in the brain and therewith modulating a variety of neurosignaling pathways. Single nucleotide polymorphisms (SNPs) in the genes encoding estrogen receptors might influence these actions and thereby play a role in the genetic foundation of mood disorders. Several SNPs in the estrogen receptor 1 (ESR1) gene have been studied in relation to anxiety and depression, while confounders and interaction with psychosocial factors have largely been overlooked. The present study investigated the effect of the functional polymorphisms rs2234693 (PvuII) and rs9340799 (XbaI) in the ESR1 gene on depression and anxiety symptoms as well as their interaction with early life adversities and parenting in two independent female cohorts, considering relevant confounding factors. In adolescent females (n = 1036), the rs9340799 minor allele (G) was found to protect against increasing anxiety symptoms from age 14 to 17, whereas, in young adult females (n = 1314, mean age: 22.2 years), it was associated with a greater risk of experiencing above-threshold anxiety symptoms. No genetic effect was found for rs2234693 and depressive symptoms in either cohort. A significant three-way gene-environment interaction was observed between rs9340799, stressful early life events, and supportive parenting on anxiety symptoms in female adolescents. These findings suggest a potential differential plasticity of the G allele in relation to anxiety symptoms in female youth. By incorporating longitudinal assessments and gene-environment analyses, this study contributes to the literature on internalizing symptoms in females in the context of estrogen-related constitutive vulnerability.}, issn = {0278-5846} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_qandeelmais_2025_2, title = {Genocidal Surveillant Assemblage in Palestine : A Socio-Legal Analysis}, author = {Qandeel, Mais and Topak, Ozgun Erdener}, year = {2025}, journal = {Journal of Genocide Research}, doi = {10.1080/14623528.2025.2567372}, url = {2007950}, language = {eng}, publisher = {Routledge}, issn = {1462-3528} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_leesangmi_2025, title = {Genome-Wide Analysis of Cadmium Resistance Genes Harbored by Cadmium-Resistant Listeria monocytogenes Strains from Sweden}, author = {Lee, Sangmi and Tham, Wilhelm and Danielsson Tham, Marie-Louise and Lopez-Valladares, Gloria and Chen, Yi and Brown, Phillip and Kathariou, Sophia}, year = {2025}, url = {1955995}, language = {eng}, abstract = {Introduction: Listeria monocytogenes causes listeriosis and often exhibits resistance to cadmium. While multiple cadmium resistance genes have been identified, our understanding of the full landscape of cadmium resistance determinants is far from complete.Purpose: This study aims to investigate cadmium resistance genes via genome-wide screening of cadmium-resistant L. monocytogenes from human listeriosis in Sweden.Methods: Thirty-two cadmium-resistant isolates were subjected to the whole genome sequencing. Plasmid-borne contigs were identified in silico and cadmium resistance genes were found by BLAST2 with known cadmium resistance genes and pan-genome analysis. These genes were compared and the deduced proteins were aligned with the prototype proteins, bootstrapped, and visualized. To determine the location of the genes, the DNA sequences including flanking regions were compared with each other and, for chromosomal cadmium resistance genes, with the complete genome of strain F2365.Results: We identified three known cadmium resistance operons (cadA1C1, cadA2C2, and cadA4C4) and two that were novel (cadD8A8 and cadA9C9). cadA1C1 was found most frequently and was plasmid borne, except for one CC101 strain that harbored a cadA1C1-harboring chromosomal island. Chromosomal islands with cadmium resistance genes also included the previously characterized LGI2 (cadA4C4 and arsenic resistance genes) and a novel island harboring cadA9C9 and an arsenic resistance gene. All cadA9C9-positive strains lacked plasmids and other cadmium resistance operons. Our analysis also identified cadA10, which was chromosomally harbored by all strains in our panel and the cadmium-susceptible strain F2365, suggesting that it mediates innate baseline resistance of L. monocytogenes to cadmium.Significance: Our findings highlight the complex distribution of cadmium resistance genes within L. monocytogenes, which will help us understand the genes that facilitate ecological adaptations, potentially leading to persistence in the environment and increased risk of L. monocytogenes-contaminated foods and foodborne infections.}, file = {https://oru.diva-portal.org/smash/get/diva2:1955995/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vanderlaancamielm_2025, title = {Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes}, author = {van der Laan, Camiel M. and Larsson, Henrik and Llonga, Natalia}, year = {2025}, journal = {Nature Genetics}, volume = {57}, number = {10}, pages = {2427--2435}, doi = {10.1038/s41588-025-02295-y}, url = {1998850}, language = {eng}, publisher = {Nature Publishing Group}, abstract = {We performed a genome-wide association meta-analysis (GWAMA) of 290,134 attention-deficit/hyperactivity disorder (ADHD) symptom measures of 70,953 unique individuals from multiple raters, ages and instruments (ADHDSYMP). Next, we meta-analyzed the results with a study of ADHD diagnosis (ADHDOVERALL). ADHDSYMP returned no genome-wide significant variants. We show that the combined ADHDOVERALL GWAMA identified 39 independent loci, of which 17 were new. Using a recently developed gene-mapping method, Fine-mapped Locus Assessment Model of Effector genes, we identified 22 potential ADHD effector genes implicating several new biological processes and pathways. Moderate negative genetic correlations (rg < -0.40) were observed with multiple cognitive traits. In three cohorts, polygenic scores (PGSs) based on ADHDOVERALL outperformed PGSs based on ADHD symptoms and diagnosis alone. Our findings support the notion that clinical ADHD is at the extreme end of a continuous liability that is indexed by ADHD symptoms. We show that including ADHD symptom counts helps to identify new genes implicated in ADHD.}, issn = {1061-4036} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_golpariandaniel_2025, title = {Genomic surveillance of Neisseria gonorrhoeae : a crucial tool in the global fight against antimicrobial resistance}, author = {Golparian, Daniel and Maatouk, Ismael and Unemo, Magnus}, year = {2025}, journal = {Expert Review of Anti-Infective Therapy}, volume = {23}, number = {10}, pages = {855--858}, doi = {10.1080/14787210.2025.2569049}, url = {2003106}, language = {eng}, publisher = {Expert Reviews Ltd.}, keywords = {neisseria gonorrhoeae; antimicrobial resistance; global; surveillance; whole-genome sequencing}, issn = {1478-7210} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bettachekarim_2025, title = {Geopolitical Psychology : An Emerging Perspective}, author = {Bettache, Karim and Chiu, Chi‐Yue and Khan, Sammyh}, year = {2025}, journal = {Journal of Social Issues}, volume = {81}, number = {4}, doi = {10.1111/josi.70049}, url = {2027587}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {geoculture; geoeconomics; geopolitical psychology; geopolitics; political psychology}, abstract = {This article aims to introduce geopolitical psychology as an emerging interdisciplinary perspective in psychological science. Broadly defined, this perspective (a) synergizes insights from geography, political economy, and psychology, and (b) broadens and deepens the understanding of the society-psychology nexus and its transformations vis-& agrave;-vis the transactions of the person and the historical, current, and imagined geopolitical contexts. We propose eight propositions to organize currently disparate research on geopolitical psychology and guide future investigations in this field. We also elaborate on the methodology of geopolitical psychology. We believe that geopolitical psychology can deepen the understanding of key social and psychological phenomena, offer new theoretical insights, lead to critical interrogations of received social representations, and inspire collective actions to change the status quo. We also expect geopolitical psychology to be able to address past critiques of intrapersonal psychology as a socially indifferent science, and conceptually and methodologically connect psychological science with its cognate disciplines in humanities and social sciences.}, issn = {0022-4537} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_unemomagnus_2025, title = {Gepotidacin shows promise for the treatment of uncomplicated gonorrhoea}, author = {Unemo, Magnus and Wi, Teodora}, year = {2025}, journal = {The Lancet}, volume = {405}, number = {10489}, pages = {1560--1562}, doi = {10.1016/S0140-6736(25)00680-4}, url = {1954506}, language = {eng}, publisher = {Elsevier}, issn = {0140-6736} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrkvallanders_2025_2, title = {Getting Rid of ‘Either Or’ in Processes of Digitalization and De-Digitalization of Schools? The Digital Pencil as Boundary Object}, author = {Björkvall, Anders and Melander, Ida}, year = {2025}, journal = {Seychelles Research Journal (SRJ)}, volume = {7}, number = {Special Conference Issue}, pages = {7--29}, url = {1993768}, language = {eng}, publisher = {The University of Seychelles}, keywords = {sub-saharan africa; ict (information and communication technology); digitalization; de-digtialization; digital pencil; boundary object; digital literacies; analogue literacies; sweden; seychelles}, abstract = {Globally, the degree to which educational practices have been digitalized varies significantly. Many countries in sub-Saharan Africa, including Seychelles, are beginning to integrate digital tools into their educational systems and developing ICT (Information and Communication Technology) policies. Sweden, on the other hand, has experienced extensive digitalization of education for many years, and is already in a state of politically driven de-digitalization. This article argues that there are conclusions to be drawn from the massive digitalization and subsequent de-digitalization of education in Sweden that may be relevant for digitalization policies in sub-Saharan African contexts where such policies can still be adjusted in order to avoid sharp dichotomies between digital and analogue tools. Drawing on two studies in Swedish classrooms – Grades Four and Eight – this paper examines how digital pencils can function as boundary objects that mitigate digital-analogue dichotomies. The analysis shows how digital pencils can function as boundary objects that connect digital classrooms – as are most Swedish classrooms – to (previous) analogue literacy practices, such as writing and drawing by hand. Importantly, the paper also argues that digital pencils can probably function as boundary objects that facilitate the transition of analogue literacies into more digital ones in African contexts, without disconnecting from the use of pencils and paper.}, file = {https://oru.diva-portal.org/smash/get/diva2:1993768/FULLTEXT02.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_xusaiqin_2025, title = {Ghost of the Navigator : Spoofing Attack Against Direction-of-Arrival Estimation}, author = {Xu, Saiqin and Brighente, Alessandro and Chen, Baixiao and Conti, Mauro and Peng, Shuai}, year = {2025}, journal = {IEEE Internet of Things Journal}, volume = {12}, number = {23}, pages = {49932--49941}, doi = {10.1109/JIOT.2025.3608829}, url = {2022727}, language = {eng}, publisher = {IEEE}, keywords = {direction-of-arrival estimation; receivers; radar; estimation; radar antennas; security; physical layer; pedestrians; signal processing algorithms; sensors; direction-of-arrival (doa) estimation; physical layer attacks; sensor security; spoofing}, abstract = {Direction-of-arrival (DOA) estimation has been widely studied and applied in real-life systems. However, little attention has been given to the risk posed by attackers trying to hide real targets or create fake ones. This poses a serious security and safety concern, as such attacks could lead to system failures or accidents. In this article, we propose DOA spoofing, the first physical layer attack that exploits the semantic gap between DOA estimation outputs and the existing physical location of targets to spoof the perceived sources' location. We consider two scenarios: 1) the attacker wants to create ghost targets at desired locations while being undetected and 2) the attacker wants to change the DOA estimated at the receiver for a target victim. To evaluate the effectiveness of DOA spoofing, we test it against several widely used and well-established DOA estimation algorithms. Via extensive numerical simulations, we demonstrate that in both scenarios, the attacker can spoof DOA estimates at the receiver while not being detected among the targets. To the best of our knowledge, this article presents the first study to examine the impact of DOA attacks on the behavior of radar perception models. Therefore, although not providing a real-life testbed due to the challenges of implementing a noncommercial multiantenna system, our contribution exposes novel threats thanks to the use of algorithms and models commonly used in real-life DOA estimation.}, issn = {2327-4662} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_isacssonalexander_2025_2, title = {Gifts as Media in the Construction of Princes : A Case Study of Duke Johan of Östergötland}, author = {Isacsson, Alexander}, year = {2025}, journal = {The Sixteenth Century Journal}, volume = {56}, number = {2}, pages = {373--393}, doi = {10.1086/735051}, url = {1963233}, language = {eng}, publisher = {Sixteenth Century Journal Publishers, Inc.}, abstract = {This article examines the media construction of Duke Johan of Östergötland (1589–1618), a Swedish prince, through the lens of his recorded gift giving practices. It posits that gifts should be conceptualized as media, shaping the construction of Duke Johan as a ruler and virtuous prince, both in the early seventeenth century and for posterity. By analyzing the remediation of Duke Johan’s gift giving practices in primary sources such as account books, letters, testaments, and funeral sermons, this study proposes a novel approach to gift analysis. It emphasizes that all archives are media archives, suggesting implications for understanding princes not only as producers and content of media but also as media entities themselves.}, issn = {0361-0160} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_sultanulrika_2025, title = {Girls, STEM, and Coding}, author = {Sultan, Ulrika}, year = {2025}, url = {1946343}, language = {eng}, publisher = {Sage Publications}, keywords = {gender disparities in stem; women in technology; coding for girls; gender stereotypes in education; inclusive stem education}, abstract = {Gender disparities in science, technology, engineering, and mathematics (STEM) remain a persistent issue, particularly in fields like coding and computer science, where girls and women are significantly underrepresented. Despite ongoing efforts to increase participation, the gender gap persists due to historical, cultural, and societal factors. Coding, a crucial skill in today’s digital world, has become a central focus for many educational initiatives aimed at addressing these imbalances. This entry explores the barriers girls face in accessing STEM, the stereotypes that discourage their participation, and the lack of early encouragement. It also highlights coding as a tool for empowerment and self-efficacy. It highlights how to foster greater inclusivity and opportunities for girls in STEM.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_2025_1, title = {Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950–2023 : a demographic analysis for the Global Burden of Disease Study 2023}, year = {2025}, journal = {The Lancet}, volume = {406}, number = {10513}, pages = {1731--1810}, doi = {10.1016/S0140-6736(25)01330-3}, url = {2006092}, language = {eng}, publisher = {Elsevier}, abstract = {BackgroundComprehensive, comparable, and timely estimates of demographic metrics—including life expectancy and age-specific mortality—are essential for evaluating, understanding, and addressing trends in population health. The COVID-19 pandemic highlighted the importance of timely and all-cause mortality estimates for being able to respond to changing trends in health outcomes, showing a strong need for demographic analysis tools that can produce all-cause mortality estimates more rapidly with more readily available all-age vital registration (VR) data. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) is an ongoing research effort that quantifies human health by estimating a range of epidemiological quantities of interest across time, age, sex, location, cause, and risk. This study—part of the latest GBD release, GBD 2023—aims to provide new and updated estimates of all-cause mortality and life expectancy for 1950 to 2023 using a novel statistical model that accounts for complex correlation structures in demographic data across age and time.MethodsWe used 24 025 data sources from VR, sample registration, surveys, censuses, and other sources to estimate all-cause mortality for males, females, and all sexes combined across 25 age groups in 204 countries and territories as well as 660 subnational units in 20 countries and territories, for the years 1950–2023. For the first time, we used complete birth history data for ages 5–14 years, age-specific sibling history data for ages 15–49 years, and age-specific mortality data from Health and Demographic Surveillance Systems. We developed a single statistical model that incorporates both parametric and non-parametric methods, referred to as OneMod, to produce estimates of all-cause mortality for each age-sex-location group. OneMod includes two main steps: a detailed regression analysis with a generalised linear modelling tool that accounts for age-specific covariate effects such as the Socio-demographic Index (SDI) and a population attributable fraction (PAF) for all risk factors combined; and a non-parametric analysis of residuals using a multivariate kernel regression model that smooths across age and time to adaptably follow trends in the data without overfitting. We calibrated asymptotic uncertainty estimates using Pearson residuals to produce 95% uncertainty intervals (UIs) and corresponding 1000 draws. Life expectancy was calculated from age-specific mortality rates with standard demographic methods. For each measure, 95% UIs were calculated with the 25th and 975th ordered values from a 1000-draw posterior distribution.FindingsIn 2023, 60·1 million (95% UI 59·0–61·1) deaths occurred globally, of which 4·67 million (4·59–4·75) were in children younger than 5 years. Due to considerable population growth and ageing since 1950, the number of annual deaths globally increased by 35·2% (32·2–38·4) over the 1950–2023 study period, during which the global age-standardised all-cause mortality rate declined by 66·6% (65·8–67·3). Trends in age-specific mortality rates between 2011 and 2023 varied by age group and location, with the largest decline in under-5 mortality occurring in east Asia (67·7% decrease); the largest increases in mortality for those aged 5–14 years, 25–29 years, and 30–39 years occurring in high-income North America (11·5%, 31·7%, and 49·9%, respectively); and the largest increases in mortality for those aged 15–19 years and 20–24 years occurring in Eastern Europe (53·9% and 40·1%, respectively). We also identified higher than previously estimated mortality rates in sub-Saharan Africa for all sexes combined aged 5–14 years (87·3% higher in GBD 2023 than GBD 2021 on average across countries and territories over the 1950–2021 period) and for females aged 15–29 years (61·2% higher), as well as lower than previously estimated mortality rates in sub-Saharan Africa for all sexes combined aged 50 years and older (13·2% lower), reflecting advances in our modelling approach. Global life expectancy followed three distinct trends over the study period. First, between 1950 and 2019, there were considerable improvements, from 51·2 (50·6–51·7) years for females and 47·9 (47·4–48·4) years for males in 1950 to 76·3 (76·2–76·4) years for females and 71·4 (71·3–71·5) years for males in 2019. Second, this period was followed by a decrease in life expectancy during the COVID-19 pandemic, to 74·7 (74·6–74·8) years for females and 69·3 (69·2–69·4) years for males in 2021. Finally, the world experienced a period of post-pandemic recovery in 2022 and 2023, wherein life expectancy generally returned to pre-pandemic (2019) levels in 2023 (76·3 [76·0–76·6] years for females and 71·5 [71·2–71·8] years for males). 194 (95·1%) of 204 countries and territories experienced at least partial post-pandemic recovery in age-standardised mortality rates by 2023, with 61·8% (126 of 204) recovering to or falling below pre-pandemic levels. There were several mortality trajectories during and following the pandemic across countries and territories. Long-term mortality trends also varied considerably between age groups and locations, demonstrating the diverse landscape of health outcomes globally.InterpretationThis analysis identified several key differences in mortality trends from previous estimates, including higher rates of adolescent mortality, higher rates of young adult mortality in females, and lower rates of mortality in older age groups in much of sub-Saharan Africa. The findings also highlight stark differences across countries and territories in the timing and scale of changes in all-cause mortality trends during and following the COVID-19 pandemic (2020–23). Our estimates of evolving trends in mortality and life expectancy across locations, ages, sexes, and SDI levels in recent years as well as over the entire 1950–2023 study period provide crucial information for governments, policy makers, and the public to ensure that health-care systems, economies, and societies are prepared to address the world's health needs, particularly in populations with higher rates of mortality than previously known. The estimates from this study provide a robust framework for GBD and a valuable foundation for policy development, implementation, and evaluation around the world.}, issn = {0140-6736} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_2025_2, title = {Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023 : a systematic analysis for the Global Burden of Disease Study 2023}, year = {2025}, journal = {The Lancet}, volume = {406}, number = {10513}, pages = {1811--1872}, doi = {10.1016/S0140-6736(25)01917-8}, url = {2006091}, language = {eng}, publisher = {Elsevier}, abstract = {BackgroundTimely and comprehensive analyses of causes of death stratified by age, sex, and location are essential for shaping effective health policies aimed at reducing global mortality. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 provides cause-specific mortality estimates measured in counts, rates, and years of life lost (YLLs). GBD 2023 aimed to enhance our understanding of the relationship between age and cause of death by quantifying the probability of dying before age 70 years (70q0) and the mean age at death by cause and sex. This study enables comparisons of the impact of causes of death over time, offering a deeper understanding of how these causes affect global populations.MethodsGBD 2023 produced estimates for 292 causes of death disaggregated by age-sex-location-year in 204 countries and territories and 660 subnational locations for each year from 1990 until 2023. We used a modelling tool developed for GBD, the Cause of Death Ensemble model (CODEm), to estimate cause-specific death rates for most causes. We computed YLLs as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. Probability of death was calculated as the chance of dying from a given cause in a specific age period, for a specific population. Mean age at death was calculated by first assigning the midpoint age of each age group for every death, followed by computing the mean of all midpoint ages across all deaths attributed to a given cause. We used GBD death estimates to calculate the observed mean age at death and to model the expected mean age across causes, sexes, years, and locations. The expected mean age reflects the expected mean age at death for individuals within a population, based on global mortality rates and the population's age structure. Comparatively, the observed mean age represents the actual mean age at death, influenced by all factors unique to a location-specific population, including its age structure. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 250-draw distribution for each metric. Findings are reported as counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2023 include a correction for the misclassification of deaths due to COVID-19, updates to the method used to estimate COVID-19, and updates to the CODEm modelling framework. This analysis used 55 761 data sources, including vital registration and verbal autopsy data as well as data from surveys, censuses, surveillance systems, and cancer registries, among others. For GBD 2023, there were 312 new country-years of vital registration cause-of-death data, 3 country-years of surveillance data, 51 country-years of verbal autopsy data, and 144 country-years of other data types that were added to those used in previous GBD rounds.FindingsThe initial years of the COVID-19 pandemic caused shifts in long-standing rankings of the leading causes of global deaths: it ranked as the number one age-standardised cause of death at Level 3 of the GBD cause classification hierarchy in 2021. By 2023, COVID-19 dropped to the 20th place among the leading global causes, returning the rankings of the leading two causes to those typical across the time series (ie, ischaemic heart disease and stroke). While ischaemic heart disease and stroke persist as leading causes of death, there has been progress in reducing their age-standardised mortality rates globally. Four other leading causes have also shown large declines in global age-standardised mortality rates across the study period: diarrhoeal diseases, tuberculosis, stomach cancer, and measles. Other causes of death showed disparate patterns between sexes, notably for deaths from conflict and terrorism in some locations. A large reduction in age-standardised rates of YLLs occurred for neonatal disorders. Despite this, neonatal disorders remained the leading cause of global YLLs over the period studied, except in 2021, when COVID-19 was temporarily the leading cause. Compared to 1990, there has been a considerable reduction in total YLLs in many vaccine-preventable diseases, most notably diphtheria, pertussis, tetanus, and measles. In addition, this study quantified the mean age at death for all-cause mortality and cause-specific mortality and found noticeable variation by sex and location. The global all-cause mean age at death increased from 46·8 years (95% UI 46·6–47·0) in 1990 to 63·4 years (63·1–63·7) in 2023. For males, mean age increased from 45·4 years (45·1–45·7) to 61·2 years (60·7–61·6), and for females it increased from 48·5 years (48·1–48·8) to 65·9 years (65·5–66·3), from 1990 to 2023. The highest all-cause mean age at death in 2023 was found in the high-income super-region, where the mean age for females reached 80·9 years (80·9–81·0) and for males 74·8 years (74·8–74·9). By comparison, the lowest all-cause mean age at death occurred in sub-Saharan Africa, where it was 38·0 years (37·5–38·4) for females and 35·6 years (35·2–35·9) for males in 2023. Lastly, our study found that all-cause 70q0 decreased across each GBD super-region and region from 2000 to 2023, although with large variability between them. For females, we found that 70q0 notably increased from drug use disorders and conflict and terrorism. Leading causes that increased 70q0 for males also included drug use disorders, as well as diabetes. In sub-Saharan Africa, there was an increase in 70q0 for many non-communicable diseases (NCDs). Additionally, the mean age at death from NCDs was lower than the expected mean age at death for this super-region. By comparison, there was an increase in 70q0 for drug use disorders in the high-income super-region, which also had an observed mean age at death lower than the expected value.InterpretationWe examined global mortality patterns over the past three decades, highlighting—with enhanced estimation methods—the impacts of major events such as the COVID-19 pandemic, in addition to broader trends such as increasing NCDs in low-income regions that reflect ongoing shifts in the global epidemiological transition. This study also delves into premature mortality patterns, exploring the interplay between age and causes of death and deepening our understanding of where targeted resources could be applied to further reduce preventable sources of mortality. We provide essential insights into global and regional health disparities, identifying locations in need of targeted interventions to address both communicable and non-communicable diseases. There is an ever-present need for strengthened health-care systems that are resilient to future pandemics and the shifting burden of disease, particularly among ageing populations in regions with high mortality rates. Robust estimates of causes of death are increasingly essential to inform health priorities and guide efforts toward achieving global health equity. The need for global collaboration to reduce preventable mortality is more important than ever, as shifting burdens of disease are affecting all nations, albeit at different paces and scales.}, issn = {0140-6736} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_pashbykaren_2025, title = {Global citizenship as taken-for-grantedness : reflecting on Swedish students’ trip to Tanzania}, author = {Pashby, Karen and Sund, Louise and Tryggvason, Ásgeir}, year = {2025}, journal = {Globalisation, Societies and Education}, volume = {23}, number = {4}, pages = {1029--1046}, doi = {10.1080/14767724.2023.2243836}, url = {1787764}, language = {eng}, publisher = {Taylor & Francis}, keywords = {global citizenship education; school partnerships; decolonial pedagogy; education for sustainable development; reflexive global learning}, abstract = {Swedish students regularly take part in school partnership trips to Tanzania. Yet, little research looks at the extent to which these trips support global learning. This paper is interested in the discourses that enable and constrain ethical relationality in these educative encounters. It considers existing research on global citizenship education and school partnerships in relation to decolonial engagements then analyses interview data with four students who participated in an entrepreneurship themed trip to identify discourses available to them. Students articulated an overarching discourse of taken-for-grantedness. Several sub-discourses could enable but tend to constrain an ethical relationality in these educative encounters.}, issn = {1476-7724}, file = {https://oru.diva-portal.org/smash/get/diva2:1787764/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_golpariandaniel_2025_1, title = {Global distribution of Xpert CT/NG assay Neisseria gonorrhoeae escape variants indicates sporadic emergence with limited clonality between 2016 and 2025}, author = {Golparian, Daniel and Bazzo, Maria Luiza and Gaspar, Pamela Cristina and Unemo, Magnus}, year = {2025}, journal = {Eurosurveillance}, volume = {30}, number = {46}, doi = {10.2807/1560-7917.ES.2025.30.46.2500817}, url = {2016746}, language = {eng}, publisher = {European Centre for Disease Prevention and Control}, keywords = {genexpert; neisseria gonorrhoeae; xpert ct/ng; antimicrobial resistance; diagnostic-escape variant; gonorrhoea; multidrug-resistant n. gonorrhoeae (mdr-gc); travel}, abstract = {Screening of 54,837 gonococcal genomes identified 12 new variants lacking one (n = 9) or both (n = 3) of the Xpert CT/NG assay's gonococcal targets. In total, 17 diagnostic-escape variants occurred across five countries and multiple genomic lineages; phylogenomic analysis revealed both ancestral and strain-specific recombination events. Xpert CT/NG diagnostic escape remains rare (0.026%) but illustrates recurrent recombination in gonococci. This emphasises the necessity of continuous external quality assessments, supplementary testing of gonococcal-positive molecular screening samples, and appropriate genomic and epidemiologic surveillance.}, issn = {1025-496X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_suciunicolae_2025, title = {Global random walk for one-dimensional one-phase Stefan-type moving-boundary problems : simulation results}, author = {Suciu, Nicolae and Nepal, Surendra and Wondmagegne, Yosief and Ögren, Magnus and Muntean, Adrian}, year = {2025}, journal = {Computational and Applied Mathematics}, volume = {44}, number = {7}, doi = {10.1007/s40314-025-03334-4}, url = {1986061}, language = {eng}, publisher = {Springer}, keywords = {global random walk approximation; stefan-type moving-boundary problems; finite element approximation; order of convergence; diffusion in rubber}, abstract = {This work presents global random walk approximations of solutions to one-dimensional Stefan-type moving-boundary problems. We are particularly interested in the case when the moving boundary is driven by an explicit representation of its speed. This situation is usually referred to in the literature as moving-boundary problem with kinetic condition. As a direct application, we propose a numerical scheme to forecast the penetration of small diffusants into a rubber-based material. To check the quality of our results, we compare the numerical results obtained by global random walks either using the analytical solution to selected benchmark cases or relying on finite element approximations with a priori known convergence rates. It turns out that the global random walk concept can be used to produce good quality approximations of the weak solutions to the target class of problems.}, issn = {2238-3603} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_clydedanielle_2025, title = {Global Variations in Practices after Bariatric and Metabolic Surgery; the PARTNER Study}, author = {Clyde, Danielle and Stenberg, Erik and Yang, Wah}, year = {2025}, journal = {Obesity Surgery}, volume = {35}, number = {12}, pages = {5357--5378}, doi = {10.1007/s11695-025-08356-9}, url = {2013551}, language = {eng}, publisher = {Springer}, keywords = {bariatric and metabolic surgery; follow-up; postoperative care}, abstract = {BACKGROUND: With over 1 billion individuals affected globally, obesity and obesity related diseases is now a leading cause of death. Metabolic and bariatric surgery (MBS) has emerged as a cornerstone intervention for severe obesity and its associated comorbidities. Despite its efficacy, postoperative care and follow-up after MBS remains highly variable worldwide.OBJECTIVE: The PARTNER study aimed to evaluate global clinical practices in the postoperative management following MBS by surveying multidisciplinary healthcare professionals.METHODS: This study was an international online survey conducted between October 2024 and January 2025. A multidisciplinary team developed the questionnaire based on existing literature and international guidelines. The survey assessed five domains: follow-up care, postoperative treatment, dietary management, patient support, and measurement of surgical outcomes. Responses were analysed descriptively.RESULTS: A total of 262 responses were received from 62 countries. Most respondents were bariatric surgeons (72.1%) working in public healthcare systems (73.3%). While 78.7% reported conducting three-month postoperative reviews, only 23.7% offered indefinite follow-up. Hybrid models of care (virtual and in-person) were common (56.9%). VTE prophylaxis and postoperative PPI use were recommended by 64.1% and 84.3% respectively. Nearly all respondents (98.1%) provided dietary advice, with protein and micronutrient supplementation widely endorsed. Only 56.1% routinely referred patients for psychological follow-up. Definitions of surgical success and failure varied widely, with inconsistent objective outcome measures.CONCLUSION: The PARTNER study reveals significant international variation in postoperative management practices following MBS. These findings underscore the need for more standardized, evidence-based guidelines to improve long-term outcomes and equity of care worldwide.}, issn = {0960-8923} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_dahlizabelaa_2025_2, title = {Globalization : Challenges and Effects on Europe Post-WWII}, author = {Dahl, Izabela A.}, year = {2025}, pages = {1--18}, doi = {10.5772/intechopen.1010818}, url = {1965324}, language = {eng}, publisher = {IntechOpen}, keywords = {globalization; european integration; cold war; east-west relations; development trajectories}, abstract = {Globalization is often used in research as an empirical lens to examine ongoing developments over time, a process that integrates people and nations into larger structures and communities while dissolving traditional barriers. Historians argue that innovations in technology, transportation, and communication have driven globalization over the long term. However, a significant shift occurred with the end of the Cold War, which notably accelerated European political and economic integration. This study examines Europe’s integration processes from a historical perspective and explores the differing development trajectories in Western and Eastern Europe before the collapse of the Soviet Union in terms of their political and economic progress toward the neoliberal democratic framework of the twentieth century. The central hypothesis of this contribution is that the divergent development paths of Eastern and Western Europe are primarily attributable to the Soviet Union’s influence on international relations during the Cold War. However, some common development paths that extend beyond the political and ideological division of Europe can be recognized with respect to the shared need for welfare. This chapter explores the causes, challenges, and effects of European globalization, focusing on the key economic, political, and social factors that have influenced this process.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_jansanders_2025, title = {Glycemic effects after bariatric surgery}, author = {Jans, Anders}, year = {2025}, url = {1904155}, language = {eng}, publisher = {Örebro University}, keywords = {obesity; gastric bypass; sleeve gastrectomy; bariatric surgery; metabolic surgery; diabetes mellitus type 2; hypoglycemia}, abstract = {Bariatric surgery, these days commonly implemented with Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG), is an effective way for patients with obesityto lose weight. In patients with obesity and concomitant type 2 diabetes mellitus (T2D), it has been observed that a significant proportion achieve remission of their diabetes after bariatric surgery. Bariatric surgery usually causes food to reach the intestine more quickly, which can cause unpleasant symptoms (dumping) and in some cases causes post-bariatric hypoglycemia (PBH).Study I aimed to analyze how the duration of diabetes before surgery affects the chance of diabetes remission. There was a clear association, in which short diabetes duration and less severe diabetes before surgery entailed an improved chance of remission.The primary goal of Study II was to study the factors that can predict late relapse of diabetes in patients who initially achieve diabetes remission after obesity surgery. It was concluded that longer diabetes duration, higher preoperative HbA1c value, less postoperative weight loss, female sex, and insulin treatment before surgery increase the risk of relapse of diabetes after initial remission.In Study III, the English-language Dumping Severity Scale (DSS) questionnaire was translated into Swedish (DSS-Swe). The DSS-Swe questionnaire was then reliability tested for Swedish conditions. The questionnaire rates eight symptoms associated with dumping and six symptoms associated with hypoglycemia. The DSS-Swe was considered to have good reliability regarding both internal consistency and test-retest performance for use in Swedish populations.The aim of Study IV was to study the prevalence of dumping and PBH symptoms at different time points before and after bariatric surgery using the DSS-Swe questionnaire. The conclusion was that symptoms of dumping and PBH were common after RYGB, while no significant increase was observed after SG.}, file = {https://oru.diva-portal.org/smash/get/diva2:1904155/FULLTEXT06.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nikolopoulosd_2025, title = {GLYCOSYLATION CHANGES OF IgG, C3 AND ALPHA-1-ACID GLYCOPROTEIN (AGP) OVER ONE YEAR OF TREATMENT FOR INCIDENT LUPUS NEPHRITIS ARE ASSOCIATED WITH RENAL OUTCOME}, author = {Nikolopoulos, D. and Pučić-Baković, M. and Šimunović, J. and Patenaude, A. M. and Vučković, F. and Pribić, T. and Tamirou, F. and Lauc, G. and Houssiau, F. and Parodis, Ioannis}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {84}, number = {Suppl. 1}, pages = {1267--1268}, doi = {10.1016/j.ard.2025.06.553}, url = {1986313}, language = {eng}, publisher = {Elsevier}, keywords = {biomarkers; renal system; -omics}, abstract = {Background: Lupus nephritis (LN) represents a severe manifestation of systemic lupus erythematosus (SLE) that is characterised by unpredictable short- and long-term outcomes due to the absence of reliable biomarkers. Distinct roles for immunoglobulin G (IgG), complement component 3 (C3), and alpha-1-acid glycoprotein (AGP; acute phase glycoprotein) in inflammation are recognised, and the importance of their N-glycosylation has been postulated in studies where biomarker potentiality has been documented within several autoimmune diseases.Objectives: To investigate whether changes in the N-glycosylation of IgG, C3, and AGP over one year of treatment for LN are associated with short-term outcomes, including histological and clinical parameters, and long-term kidney outcomes, including renal flares and impairment of renal function.Methods: Serum samples from 19 treatment-naïve patients with incident LN were collected before and one year after commencement of treatment. From those, we isolated IgG (Fc, Fab, total), C3, AGP, and total serum glycoproteins, which were analyses either as released N-glycans or N-glycopeptides using high-throughput glycoanalytical approaches. All patients underwent per-protocol repeat kidney biopsy. Paired t-test was used to identify significantly altered levels of N-glycosylation traits following treatment. Spearman's rank correlation was applied to assess the relationship between changes in N-glycosylation trait levels (delta, Δ) and changes in short-term outcomes (delta, Δ), including renal pathology National Institutes of Health (NIH) activity and chronicity index scores, urinary protein-to-creatinine ratio (UPCR), serum creatinine (sCr), and estimated glomerular filtration rate (eGFR). Logistic regression was applied to examine whether changes in N-glycosylation trait levels are associated with treatment responses at one year, as well as with long-term outcomes, including renal flares and renal impairment (eGFR <60 mL/min/1.73m², sustained for at least two measurements, at least three months apart).Results: In total, we identified 44/243 increased N-glycosylation traits(7 total IgG, 8 IgG Fc, 8 IgG Fab, 11 serum glycoproteins, 9 AGP, and 1 C3) and 41/243 decreased N-glycosylation traits (10 total IgG, 4 IgG Fc, 3 IgG Fab, 7 serum proteins, 11 AGP, and 2 C3) following treatment. We observed a significant negative correlation between changes of NIH activity index scores and the changes of the increased total IgG A2[6]G1 N-glycan (GP16; r=-0.64; p=0.005), total IgG asialylated N-glycans (S0; r=-0.53; p=0.03), serum high-mannose N-glycans (HM; r=-0.56; p=0.02), and a significant positive correlation between changes of NIH activity index scores and changes of the decreased C3 N2H5 N-glycopeptide (CIIIKTVLT1N2H5; r=0.51; p=0.04) and total IgG A2G2[6]S1 N-glycan (GP9; r=0.51; p=0.04). However, Nglycosylation changes were not associated with changes in NIH chronicity index score changes. Of the increased N-glycosylation traits, changes of serum M6 and FA2[3]BG1 N-glycans (GP7; r=-0.65; p=0.002), serum A2G2 N-glycan (GP8, r=-0.56; p=0.01), serum M9 N-glycan (GP19; r=-0.49; p=0.03), and serum high-mannose N-glycans (HM; r=-0.57; p=0.01) negatively correlated with ΔsCr, while changes of the decreased C3 N2H5 N-glycopeptide (CIIIKTVLT1N2H5; r=0.56; p=0.01) positively correlated with ΔsCr. As expected, the same correlations were seen with the ΔeGFR, yet in the opposite direction. Changes in UPCR levels positively correlated with the changes of the increased IgG Fab A2BG2S2 N-glycan (GP2; r=0.53; p=0.02) and serum A3F1G3S2 and A3G3S3 N-glycans (GP27; r=0.59; p=0.007), and the decreased AGP N6H7S3 N-glycopeptide (IIORM1N6H7S3; r=0.47; p=0.04) and AGP N5H6S3F1 N-glycopeptide (VORMI1N5H6S3F1; r=0.56; p=0.01). Eleven increased N-glycosylation traits positively correlated with changes in serum albumin and eleven decreased glycans negatively correlated with changes in levels of serum albumin. The change in the decreased total IgG GP4 (OR=27.1; 95% CI=1.1–678.5; p=0.04) was significantly associated with clinical and histological response at month 12, while changes in glycan levels were not associated with renal impairment or subsequent renal flares during follow-up.Conclusion: This study provides a comprehensive characterisation of the glycosylation profile of proteins involved in the inflammatory response in a unique cohort of incident cases of LN, with available data from per-protocol repeat kidney biopsies and long-term follow-up. Our findings suggest that glycosylation changes over one year of treatment are associated with certain features of clinical and histological renal outcome, warranting further exploration of the potential role of glycans as biomarkers in LN.}, issn = {0003-4967} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jiemywilliamf_2025, title = {GM-CSF drives IL-6 production by macrophages in polymyalgia rheumatica}, author = {Jiemy, William F. and Zhang, Anqi and Abdulahad, Wayel H. and Reitsema, Rosanne and van Sleen, Yannick and Sandovici, Maria and Alegria, Guillermo Carvajal and Cornec, Divi and Devauchelle-Pensec, Valérie and Hemon, Patrice and Quéré, Baptiste and Boukhlal, Sara and Roozendaal, Caroline and Kwee, Thomas Christian and Dasgupta, Bhaskar and Diepstra, Arjan and Heeringa, Peter and Brouwer, Elisabeth and van der Geest, Kornelis S. M.}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {84}, number = {5}, pages = {833--843}, doi = {10.1016/j.ard.2025.01.004}, url = {1935518}, language = {eng}, publisher = {Highwire Press}, abstract = {OBJECTIVES: Insight into the immunopathology of polymyalgia rheumatica (PMR) is scarce and mainly derived from peripheral blood studies. The limited data available point towards macrophages as potential key players in PMR. This study aimed to identify the factors driving proinflammatory macrophage development and their functions in the immunopathology of PMR.METHODS: Monocyte phenotypes were investigated by flow cytometry in peripheral blood (PMR, n = 22; healthy controls, n = 20) and paired subacromial-subdeltoid (SASD) bursal fluid (PMR, n = 9). Macrophages in SASD bursa were characterised by immunohistochemistry and immunofluorescence (PMR, n = 12; controls undergoing shoulder replacement surgery, n = 10). The functions of cytokines expressed in PMR-affected tissue were examined using macrophage differentiation cultures (PMR, n = 7; healthy controls, n = 7).RESULTS: Monocytes (CD14highCD16- and CD14highCD16+) were increased in blood of PMR patients and activated in bursal fluid. Macrophages dominated immune infiltrates in PMR-affected tissue, expressing various proinflammatory cytokines. While interleukin (IL)-6 and interferon-gamma (IFN-γ) expression was abundant in both PMR and control tissue, granulocyte-macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) were significantly increased in PMR tissue. Macrophages in PMR-affected tissue showed an elevated CD206/folate receptor β ratio, reflecting a GM-CSF skewed signature. A combination of GM-CSF/M-CSF/IFN-γ significantly boosted IL-6 production in vitro, while limited IL-6 production was observed without GM-CSF.CONCLUSIONS: The monocyte compartment is expanded and activated in PMR. Macrophages in PMR-affected tissue produce abundant proinflammatory cytokines such as IL-6. A network of locally expressed cytokines, including GM-CSF, M-CSF, and IFN-γ, may drive the proinflammatory functions of these macrophages. Overall, macrophages may constitute key therapeutic targets for PMR.}, issn = {0003-4967} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_winklernicolasp_2025, title = {GNN-DM : A Graph Neural Network Framework for Real-World Gas Distribution Mapping}, author = {Winkler, Nicolas P. and Neumann, Patrick P. and Albizu, Natalia and Schaffernicht, Erik and Lilienthal, Achim}, year = {2025}, journal = {IEEE Sensors Journal}, volume = {25}, number = {22}, pages = {42171--42179}, doi = {10.1109/jsen.2025.3617158}, url = {2025850}, language = {eng}, publisher = {IEEE}, keywords = {sensors; sensor phenomena and characterization; training; layout; gas detectors; mathematical models; data models; automobiles; training data; synthetic data; environmental monitoring; gas distribution mapping (gdm); graph neural networks (gnns); sensor networks; transfer learning}, abstract = {Gas distribution mapping (GDM) is essential for industrial safety and environmental monitoring, as it enables real-time hazard detection and air quality assessment. Traditional GDM methods, such as kernel-based techniques, struggle to reconstruct complex gas plume dynamics accurately. While deep learning has shown promise for GDM, two critical challenges hinder its practical use: the scarcity of available training data and the incompatibility of conventional architectures with irregular sensor layouts. To address these limitations, we propose GNN-DM, a graph neural network-based model for GDM that incorporates the relational structure of sensor networks to infer high-resolution maps from minimal, irregular inputs. The model is pretrained on synthetic gas dispersion data generated from measured wind data and fine-tuned on two industrial datasets collected on a ferry car deck and in a hot rolling mill. Compared with established GDM techniques, GNN-DM achieves higher accuracy on synthetic and real-world data, highlighting the potential of graph-based learning for practical gas mapping applications.}, issn = {1530-437X}, file = {https://oru.diva-portal.org/smash/get/diva2:2025850/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ohaganlaurenalex_2025_3, title = {Going bananas! The scientific marketing of a 'new' fruit in early 20th-Century Sweden}, author = {O’Hagan, Lauren Alex}, year = {2025}, journal = {Food, Culture, and Society: an international journal of multidisciplinary research}, volume = {28}, number = {3}, pages = {685--710}, doi = {10.1080/15528014.2024.2338982}, url = {1860576}, language = {eng}, publisher = {Taylor & Francis}, keywords = {bananas; fyffes; marketing; advertisements; scientific discourse; nutrition; health; eating knowledge}, abstract = {This paper investigates the introduction of the banana to Sweden in the early twentieth century and how "eating knowledge" of this new and exotic fruit was transferred to consumers through marketing that drew heavily upon scientific discourse. Using a case study of advertisements from Fyffes - the most dominant banana brand of the period - it employs multimodal social semiotics to identify a range of verbal and visual strategies that were adopted to turn the product into a core part of the Swedish diet. It argues that these strategies were critical in educating Swedish people about the link between food and health and shaped their (positive) attitudes toward bananas. The banana, thus, stands as a strong example of how marketing can transport, shape and transform knowledge about food, particularly at a critical time when it is first being introduced into a country.}, issn = {1552-8014} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_gerdinmarcus_2025_1, title = {Good Variable Practice : Addressing inconsistencies in non-/compliance research using a sequential multi-method approach}, author = {Gerdin, Marcus}, year = {2025}, url = {1992303}, language = {eng}, publisher = {Örebro University}, keywords = {information security; behavioral information security; compliance; non-compliance; information security policies; pmt; tpb; umispc; good variable practice}, abstract = {This thesis examines research on employees’ behavior toward information security policies (ISPs), commonly studied under the concept of non-/compliance. While extensive research has expanded knowledge in this field, recent reviews highlight inconsistent and contradictory research findings. These inconsistencies are often attributed to contextual moderators, but this explanation is only partial. This thesis offers a complementary perspective by focusing on definitions and measurements of variables commonly used in research.Using a sequential multi-method approach, including a traditional survey, a literature review, interviews, and a survey experiments, this thesis demonstrates that non-/compliance research suffers from widespread inconsistencies/unclarities in defining and measuring key variables, both within and across studies. The thesis also finds that these inconsistencies/unclarities may contribute to differences in research results.These identified inconsistencies in variable definitions and measurements are not only of theoretical concern (in terms of theoretical specificity) but may also have significant empirical consequences insofar as they may influence research findings. Based on this, this thesis contributes to the extant literature by suggesting a research agenda specifying 12 considerations for research design that future researchers should consider in order to improve theoretical development in the field, minimize the impact of inconsistent variable definitions and measurements on research results, and, most importantly, enhance our understanding of ISP non-/compliance phenomena.}, file = {https://oru.diva-portal.org/smash/get/diva2:1992303/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kisstams_2025, title = {Good volatility, bad volatility and the cross section of commodity returns}, author = {Kiss, Tamás and Ferreira Batista Martins, Igor}, year = {2025}, journal = {Finance Research Letters}, volume = {86}, number = {Part: D}, doi = {10.1016/j.frl.2025.108656}, url = {2013183}, language = {eng}, publisher = {Elsevier}, keywords = {commodity returns; semivariance; signed jumps}, abstract = {This article studies whether asymmetries in volatility help explain the cross section of commodity returns. We decompose realized variance into upside and downside components and construct a normalized difference measure, the relative signed jump (RSJ), following Bollerslev et al. (2020). A trading strategy that goes long the top tercile of commodities with the highest RSJ and shorts the bottom tercile delivers a statistically and economically significant annualized excess return of-6.29%. We also find that our tradable RSJ factor explains the cross section of commodity returns beyond well-established factors in a multivariate price setting context. Our results also show that the pricing ability of volatility asymmetries is distinct from other higher order moments such as realized skewness.}, issn = {1544-6123}, file = {https://oru.diva-portal.org/smash/get/diva2:2013183/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_faberstinethidemann_2025, title = {Green fathering in the (m)Anthropocene}, author = {Faber, Stine Thidemann and Leer, Jonatan}, year = {2025}, journal = {Norma}, doi = {10.1080/18902138.2025.2590269}, url = {2022831}, language = {eng}, publisher = {Routledge}, keywords = {green fathering; eco-fathering; eco-villages; alternative hedonism; ecological masculinities}, abstract = {This paper examines the concept of green fathering, addressing a gap in research on how the climate crisis influences men's views on fatherhood and fathering practices. Based on a qualitative study of fathers who live in Danish eco-villages, we explore their concerns, aspirations and commitments to raising children 'the green way'. Drawing on theories of alternative hedonism and ecological masculinity, we analyse how green fathering is constituted, motivated and practiced across five interrelated dimensions. First, it is shaped through a redefinition of 'the good life' grounded in alternative hedonism; second, through a future-oriented ethic of care that emphasises the cultivation of ecological virtues in children; third, through linking visions of 'the good, green childhood' to nature, freedom, and autonomy; fourth, through a deep commitment to care and community; and fifth, through challenging dominant masculinity scripts and advocating for men's emotional and ecological accountability. We discuss how green fathering represents a critical, transformative approach, that is distinctive in these father's concern to give priority to new modes of thinking about personal as well as paternal fulfilment in order to promote positive social change for both current and future generations.}, issn = {1890-2138} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_lintongabriel_2025, title = {Grit and Effectuation in Business Model Innovation among Farmers}, author = {Linton, Gabriel and Hasche, Nina and Samuelsson, Peter}, year = {2025}, url = {1995860}, language = {eng} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_15, title = {Gränsdragningen mellan hyra och köp vid leasingtransaktioner – mervärdesskatt}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031789}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 26 november 2024 kom Skatteverkets ställningstagande ”Sale and lease back och lease and lease back, mervärdesskatt” (Dnr: 8-3161557). Professor Eleonor Kristoffersson diskuterar ställningstagandets betydelse för avdragsförbudet för förvärv av personbilar.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ohaganlaurenalex_2025_4, title = {Guest editorial : Introduction to special issue on "selling beauty"}, author = {O’Hagan, Lauren Alex and Santos, Lucy Jane}, year = {2025}, journal = {Journal of Historical Research in Marketing}, volume = {17}, number = {3-4}, pages = {121--138}, doi = {10.1108/JHRM-09-2025-0072}, url = {2014443}, language = {eng}, publisher = {Emerald Group Publishing Limited}, issn = {1755-750X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssonfredrik_2025_1, title = {Guest editorial : New frontiers in information security management}, author = {Karlsson, Fredrik and Gao, Shang}, year = {2025}, journal = {Information and Computer Security}, volume = {33}, number = {1}, pages = {1--4}, doi = {10.1108/ICS-03-2025-265}, url = {1932117}, language = {eng}, publisher = {Emerald Group Publishing Limited} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zarejeddimaryam_2025, title = {Guidance on minimum information requirements (MIR) from designing to reporting human biomonitoring (HBM)}, author = {Zare Jeddi, Maryam and Yeung, Leo W. Y. and Hopf, Nancy B.}, year = {2025}, journal = {Environment International}, volume = {202}, doi = {10.1016/j.envint.2025.109601}, url = {1981424}, language = {eng}, publisher = {Elsevier}, keywords = {chemical monitoring; contextual information; exposome; fair; harmonization; metadata requirements}, abstract = {Human biomonitoring (HBM) provides an integrated chemical exposures assessment considering all routes and sources of exposure. The accurate interpretation and comparability of biomarkers of exposure and effect depend on harmonized, quality-assured sampling, processing, and analysis. Currently, the lack of broadly accepted guidance on minimum information required for collecting and reporting HBM data, hinders comparability between studies. Furthermore, it prevents HBM from reaching its full potential as a reliable approach for assessing and managing the risks of human exposure to chemicals.The European Chapter of the International Society of Exposure Science HBM Working Group (ISES Europe HBM working group) has established a global human biomonitoring community network (HBM Global Network) to develop a guidance to define the minimum information to be collected and reported in HBM, called the "Minimum Information Requirements for Human Biomonitoring (MIR-HBM)". This work builds on previous efforts to harmonize HBM worldwide.The MIR-HBM guidance covers all phases of HBM from the design phase to the effective communication of results. By carefully defining MIR for all phases, researchers and health professionals can make their HBM studies and programs are robust, reproducible, and meaningful. Acceptance and implementation of MIR-HBM Guidelines in both the general population and occupational fields would improve the interpretability and regulatory utility of HBM data. While implementation challenges remain-such as varying local capacities, and ethical and legal differences at the national levels, this initiative represents an important step toward harmonizing HBM practice and supports an ongoing dialogue among policymakers, legal experts, and scientists to effectively address these challenges. Leveraging the data and insights from HBM, policymakers can develop more effective strategies to protect public health and ensure safer working environments.}, issn = {0160-4120} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hardcastletimothyc_2025, title = {Guidelines for Enhanced Recovery After Trauma and Intensive Care (ERATIC) : Enhanced Recovery After Surgery (ERAS) and International Association for Trauma Surgery and Intensive Care (IATSIC) Society Recommendations: Paper 2: Postoperative and Intensive Care Recommendations}, author = {Hardcastle, Timothy C. and Gaarder, Christine and Balogh, Zsolt and D'amours, Scott and Davis, Kimberly A. and Gupta, Amit and Mohseni, Shahin and Naess, Paal A. and Naidoo, Shanisa and Razek, Tarek and Robertson, Simon and Uchino, Hayaki and Zonies, David and Whing, Jade and Scott, Michael J.}, year = {2025}, journal = {World Journal of Surgery}, volume = {49}, number = {8}, pages = {2029--2054}, doi = {10.1002/wjs.70004}, url = {1988485}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {enhanced recovery after surgery; eras; major trauma; perioperative care; polytrauma}, abstract = {Background: Enhanced recovery after surgery (ERAS) protocols reduce length of stay, complications, and costs for elective surgical procedures. It remains challenging to implement ERAS concepts in the acute trauma patient due to deranged physiological reserve from the penetrating or blunt trauma producing altered physiology. However, systems of care improve access to early intervention and potentially reduce mortality. These consensus guidelines examine optimal prehospital, resuscitation-room, intraoperative and postoperative treatment, systems of ethical management, and overall care for trauma patients in the postresuscitation phase of care. The guideline is presented in three parts, this being Part 2.Methods: Experts in aspects of management of trauma surgical patients and intensive care were invited to contribute by the International ERAS Society and IATSIC. PubMed, Cochrane, Embase, and MEDLINE database searches on English language publications were performed for ERAS elements using the patient, intervention, comparator outcome (PICO) consensus questions created by the expert group. Studies were selected with particular attention to randomized clinical trials, systematic reviews, meta-analyses, and large cohort studies; reviewed and summarized recommendations were graded using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. These recommendations based on current best evidence, with extrapolation from elective patient studies, where appropriate, were followed by a modified two-round Delphi method to validate final recommendations. Several ERAS components are already standard of care within national and society guidelines and are endorsed. The bulk of the text focuses on key areas pertaining specifically to trauma care of major trauma and polytrauma in the ICU-requiring group.Results: Overall, 37 aspects of trauma care were considered, with multiple PICO questions and subpoints. Consensus was reached after two rounds of a modified Delphi process involving all authors, with minor adjustments to some phrasing required, but with 87% overall agreement on all statements (100% agreement on 31 of the main statement sets, prior to minor edits to address the points of difference for the rest, with 100% total agreement thereafter). None were rejected outright. The recommendations and level of evidence for each aspect of trauma care that may impact on improved recovery and reduced length of hospital stay are presented with grade of recommendation.Conclusions: This paper presents the results of the postoperative care and ICU aspects. The guidelines are based on current best evidence for an ERAS approach to patients who have had major injuries and polytrauma. These guidelines are not exhaustive but collate the best available evidence on important components of care for this patient population. As some of the evidence is extrapolated from elective surgery and nontrauma emergency surgery, some of the components need further evaluation in future studies.}, issn = {0364-2313} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hardcastletimothyc_2025_1, title = {Guidelines for Enhanced Recovery After Trauma and Intensive Care (ERATIC) : Enhanced Recovery After Surgery (ERAS) and International Association for Trauma Surgery and Intensive Care (IATSIC) Society Recommendations: Part 3: Trauma Ethics and Systems Aspects}, author = {Hardcastle, Timothy C. and Gaarder, Christine and Balogh, Zsolt and D'amours, Scott and Davis, Kimberly A. and Gupta, Amit and Mohseni, Shahin and Naess, Paal A. and Naidoo, Shanisa and Razek, Tarek and Robertson, Simon and Uchino, Hayaki and Zonies, David and Whing, Jade and Scott, Michael J.}, year = {2025}, journal = {World Journal of Surgery}, volume = {49}, number = {8}, pages = {2055--2065}, doi = {10.1002/wjs.70003}, url = {1988493}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {enhanced recovery after surgery; eras; major trauma; perioperative care; polytrauma}, abstract = {Background: Enhanced recovery after surgery (ERAS) protocols reduce length of stay, complications, and costs for elective surgical procedures. It remains challenging to implement ERAS concepts in the acute trauma patient due to deranged physiological reserve from the penetrating or blunt trauma producing altered physiology. However, systems of care improve access to early intervention and potentially reduce mortality. These consensus guidelines examine optimal pre-hospital, resuscitation-room, intra- and post-operative treatment, systems of ethical management, and overall care for trauma patients in the post-resuscitation phase of care. The guideline is presented in three parts, this being part 3.Methods: Experts in aspects of management of trauma surgical patients and intensive care were invited to contribute by the International ERAS Society and IATSIC. Pubmed, Cochrane, Embase, and MEDLINE database searches on English language publications were performed for ERAS elements using the patient intervention comparator outcome (PICO) consensus questions created by the expert group. Studies were selected with particular attention to randomized clinical trials, systematic reviews, meta-analyses, and large cohort studies; reviewed; and summarized recommendations were graded using the grading of recommendations, assessment, development and evaluation (GRADE) system. These recommendations based on current best evidence, with extrapolation from elective patient studies where appropriate, were followed by a modified two-round Delphi method to validate final recommendations. Several ERAS components are already standard of care within national and society guidelines and are endorsed. The bulk of the text focuses on key areas pertaining specifically to trauma care of major trauma and polytrauma in the ICU-requiring group.Results: Overall 37 aspects of trauma care were considered with multiple PICO questions and sub-points. Consensus was reached after two rounds of a modified Delphi process involving all authors, with minor adjustments to some phrasing required but with 87% overall agreement on all statements (100% agreement on 31 of the main statement sets, prior to minor edits to address the points of difference for the rest with 100% total agreement thereafter). None were rejected outright. The recommendations and level of evidence for each aspect of trauma care that may impact on improved recovery and reduced length of hospital stay are presented with grade of recommendation.Conclusions: Four main areas of relevance to ethics and systems are presented as part 3. The guidelines are based on current best evidence for an ERAS approach to patients who have had major injuries and polytrauma. These guidelines are not exhaustive but collate the best available evidence on important components of care for this patient population. As some of the evidence is extrapolated from elective surgery and non-trauma emergency surgery, some of the components need further evaluation in future studies.}, issn = {0364-2313} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hardcastletimothyc_2025_2, title = {Guidelines for Enhanced Recovery After Trauma and Intensive Care (ERATIC) : Enhanced Recovery After Surgery (ERAS) Society and International Association of Trauma Surgery and Intensive Care (IATSIC) Recommendations: Paper 1: Initial Care-Pre and Intraoperative Care Until ICU, Including Non-Operative Management}, author = {Hardcastle, Timothy C. and Gaarder, Christine and Balogh, Zsolt and D'amours, Scott and Davis, Kimberly A. and Gupta, Amit and Mohseni, Shahin and Naess, Paal A. and Naidoo, Shanisa and Razek, Tarek and Robertson, Simon and Uchino, Hayaki and Zonies, David and Whing, Jade and Scott, Michael J.}, year = {2025}, journal = {World Journal of Surgery}, volume = {49}, number = {8}, pages = {1997--2028}, doi = {10.1002/wjs.70002}, url = {1988498}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {enhanced recovery after surgery; eras; major trauma; perioperative care; polytrauma}, abstract = {Background: Enhanced recovery after surgery (ERAS) protocols reduce length of stay, complications, and costs for elective surgical procedures. It remains challenging to implement ERAS concepts in the acute trauma patient due to deranged physiological reserve from the penetrating or blunt trauma producing altered physiology. However, systems of care improve access to early intervention and potentially reduce mortality. These consensus guidelines examine optimal pre-hospital, resuscitation-room, intra-, and post-operative treatment, systems of ethical management, and overall care for trauma patients in the post-resuscitation phase of care. The guideline is presented in three parts, this being part 1.Methods: Experts in aspects of management of trauma surgical patients and intensive care were invited to contribute by the International ERAS Society and IATSIC. PubMed, Cochrane, Embase, and MEDLINE database searches on English language publications were performed for ERAS elements using the patient intervention comparator outcome (PICO) consensus questions created by the expert group. Studies were selected with particular attention to randomized clinical trials, systematic reviews, meta-analyses, and large cohort studies, reviewed, and summarized recommendations were graded using the grading of recommendations, assessment, development and evaluation (GRADE) system. These recommendations based on current best evidence, with extrapolation from elective patient studies, where appropriate, were followed by a modified two-round Delphi method to validate final recommendations. Several ERAS components are already standard of care within national and society guidelines and are endorsed. The bulk of the text focuses on key areas pertaining specifically to trauma care of major trauma and polytrauma in the ICU-requiring group.Results: Overall 37 aspects of trauma care were considered with multiple PICO questions and sub-points. Consensus was reached after two rounds of a modified Delphi process involving all authors, with minor adjustments to some phrasing required, but with 87% overall agreement on all statements (100% agreement on 31 of the main statement sets, prior to minor edits to address the points of difference for the rest with 100% total agreement thereafter). None were rejected outright. The recommendations and level of evidence for each aspect of trauma care that may impact on improved recovery and reduced length of hospital stay are presented with grade of recommendation.Conclusions: The guidelines relating to initial care and decision-making are presented in part 1 of the Guidelines. These guidelines are based on current best evidence for an ERAS approach to patients who have had major injuries and polytrauma. The guidelines are not exhaustive but collate the best available evidence on important components of care for this patient population. As some of the evidence is extrapolated from elective surgery and non-trauma emergency surgery, some of the components need further evaluation in future studies.}, issn = {0364-2313} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssonfredrik_2025_2, title = {Guidelines for Longitudinal Information Security Policy Compliance Research}, author = {Karlsson, Fredrik and Gao, Shang}, year = {2025}, url = {2007041}, language = {eng}, publisher = {Association for Information Systems}, abstract = {Over the years, numerous studies on employee compliance with information security policies (ISPs) have been conducted, contributing valuable insights to enhance information security in organisations. However, our literature review reveals that few ISP compliance studies adopt a longitudinal approach. It is well known that cross-sectional research often provides limited insight into how constructs such as ISP compliance evolve over time. While researchers have called for more longitudinal ISP compliance studies, there is little guidance on how to conduct them. To address this gap, we propose a set of seven guidelines to support both quantitative and qualitative longitudinal ISP compliance research.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_schoultzida_2025, title = {Gut microbiota development across the lifespan : Disease links and health-promoting interventions}, author = {Schoultz, Ida and Claesson, Marcus J. and Dominguez-Bello, Maria Gloria and Fåk Hållenius, Frida and Konturek, Peter and Korpela, Katri and Laursen, Martin Frederik and Penders, John and Roager, H. and Vatanen, Tommi and Öhman, Lena and Jenmalm, Maria C.}, year = {2025}, journal = {Journal of Internal Medicine}, volume = {297}, number = {6}, pages = {560--583}, doi = {10.1111/joim.20089}, url = {1954847}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {adulthood; aging; gut microbiota; infancy; inflammatory diseases; intervention}, abstract = {The gut microbiota plays a pivotal role in human life and undergoes dynamic changes throughout the human lifespan, from infancy to old age. During our life, the gut microbiota influences health and disease across life stages. This review summarizes the discussions and presentations from the symposium "Gut microbiota development from infancy to old age" held in collaboration with the Journal of Internal Medicine. In early infancy, microbial colonization is shaped by factors such as mode of delivery, antibiotic exposure, and milk-feeding practices, laying the foundation for subsequent increased microbial diversity and maturation. Throughout childhood and adolescence, microbial maturation continues, influencing immune development and metabolic health. In adulthood, the gut microbiota reaches a relatively stable state, influenced by genetics, diet, and lifestyle. Notably, disruptions in gut microbiota composition have been implicated in various inflammatory diseases-including inflammatory bowel disease, Type 1 diabetes, and allergies. Furthermore, emerging evidence suggests a connection between gut dysbiosis and neurodegenerative disorders such as Alzheimer's disease. Understanding the role of the gut microbiota in disease pathogenesis across life stages provides insights into potential therapeutic interventions. Probiotics, prebiotics, and dietary modifications, as well as fecal microbiota transplantation, are being explored as promising strategies to promote a healthy gut microbiota and mitigate disease risks. This review focuses on the gut microbiota's role in infancy, adulthood, and aging, addressing its development, stability, and alterations linked to health and disease across these critical life stages. It outlines future research directions aimed at optimizing the gut microbiota composition to improve health.}, issn = {0954-6820} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fchtbauerjohannesd_2025, title = {Gut Mycobiome in Inflammatory Bowel Disease : A Systematic Review of Case-Control Studies}, author = {Füchtbauer, Johannes D. and Brovkina, Olga and Sivickis, Kostas and Aalykke, Claus and Høivik, Marte L. and Andersen, Vibeke and Halfvarson, Jonas and Bang, Corinna and Franke, Andre and Kjeldsen, Jens}, year = {2025}, journal = {Inflammatory Bowel Diseases}, volume = {31}, number = {11}, pages = {3213--3224}, doi = {10.1093/ibd/izaf217}, url = {2002269}, language = {eng}, publisher = {Oxford University Press}, keywords = {crohn’s disease; case-control studies; mycobiome; systematic review; ulcerative colitis}, abstract = {BACKGROUND: The bacterial composition of the microbiome in inflammatory bowel disease (IBD) has been the focus of substantial interest. In contrast, the fungal part of the microbiome, the mycobiome, has only rarely been investigated-although anti-Saccharomyces cerevisiae antibodies, an antibody against fungal mannan, have been known for years as a biomarker for Crohn's disease (CD), but not for ulcerative colitis (UC).METHODS: A systematic review of case-control studies on the human gut mycobiome in IBD was conducted using searches in EMBASE and MEDLINE.RESULTS: Twenty-seven studies, with a total of 1406 IBD patients and 1060 controls were identified. The differences in alpha diversity varied across studies and were related to geography, whereas differences in beta diversity between cases and controls were found in a large majority of the studies. Overall, the results were inconsistent at different taxonomic levels, and the studied populations were heterogeneous, as were the methodological approaches. The most consistent finding was an increase of Candida for both CD and UC and of Malassezia in CD, where it was often linked to a decrease of Saccharomyces.CONCLUSIONS: The mycobiome is altered in IBD, as differences in beta diversity were found between cases and controls consistently. Future studies should carefully standardize every step from sample collection through analysis and data processing, allowing external validation of findings. Inclusion of treatment naïve patients and symptomatic controls could further advance this field.}, issn = {1078-0998} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fchtbauerjd_2025, title = {Gut mycobiome in the NORDTREAT cohort of new onset inflammatory bowel disease}, author = {Füchtbauer, J. D. and Brovkina, O. and Bang, C. and Fejrskov, A. and Aalykke, C. and Davíðsdóttir, L. and Rejler, Martin and Repsilber, Dirk and Söderholm, J. D. and Andersen, V and Høivik, M. L. and Halfvarson, Jonas and Franke, A. and Kjeldsen, J.}, year = {2025}, journal = {Journal of Crohn's & Colitis}, volume = {19}, number = {Suppl. 1}, pages = {i2404--i2405}, doi = {10.1093/ecco-jcc/jjae190.1510}, url = {1936127}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background: Inflammatory bowel disease (IBD) is a chronic disease where the aetiology is suggested to involve genetic, microbial, and environmental factors as well as their interactions. Though the bacterial component of the gut microbiome has been of substantial interest in recent years, the mycobiome (fungal community) is less studied. Recent studies have, however, shown that the efficacy of faecal microbiota transplantation in ulcerative colitis (UC) is dependent on the pre-transplantation of host mycobiome. Furthermore, there is an association between anti-Saccharomyces cerevisiae antibodies (ASCA) for Crohn’s disease (CD), but not UC. We aimed to characterize the gut mycobiome of incident IBD patients.Methods: In this study, we analysed samples from 216 adult treatment-naïve patients in the NORDTREAT cohort, who were referred on suspicion of IBD. Patients were recruited in 4 Nordic countries from 2022 to 20231. The diagnosis of IBD was based on internationally accepted criteria (UC n=72, CD n=48 and IBD-unclassified [IBD-U] n=8) or, if IBD was ruled out, categorized as symptomatic controls (SC, n=88). Stool samples and colonic biopsies were collected at inclusion. From these, DNA was extracted, and ITS2 amplicon sequencing was performed as previously described2. The primary end-point of subsequent bioinformatic analysis was relative abundance at the genus level. The secondary end-points were alpha and beta diversity, as well as a correlation analysis between faecal samples and biopsies.Results: The relative abundance at genus level was dominated by Saccharomyces in stool samples whereas this genus was markedly reduced in biopsies and Malassezia was found to be increased (see figure 1, data not shown for IBD-U). We did not observe statistically significant differences in relative abundance between patient groups. Alpha diversity and beta diversity did not significantly differ for fungi across patient groups, neither in stool nor in biopsies. However, canonical correspondence analysis of the dominant genera between biopsies and faecal samples demonstrated a low constrained proportion in SC (0,2), increasing from UC (0,25) through CD (0,5) indicating that in CD, the mycobiome of stool and mucosa is more similar than in the UC and SC.Conclusion: This study of the gut mycobiome in new onset and treatment naïve IBD patients is the largest so far and does not find evidence of disease specific differences. Previous reports with inconsistent findings regarding alterations of the mycobiome in IBD patients might rather reflect treatment effects than a role of the mycobiome in disease aetiology.References:1.Fejrskov A, Füchtbauer JD, Davíðsdóttir LG, et al. Novel biomarker profiles to improve individual diagnosis and prognosis in patients with suspected inflammatory bowel disease: protocol for the Nordic inception cohort study (NORDTREAT). BMJ Open. 2024;14(5):e083144. doi:10.1136/bmjopen-2023-0831442.Rühlemann MC, Solovjeva MEL, Zenouzi R, et al. Gut mycobiome of primary sclerosing cholangitis patients is characterised by an increase of Trichocladium griseum and Candida species. Gut. Published online October 25, 2019. doi:10.1136/gutjnl-2019-320008}, issn = {1873-9946} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssonmagnus_2025_1, title = {Gårdsförsäljning av alkohol - en milstolpe i svensk alkoholpolitik}, author = {Kristoffersson, Magnus and Kristoffersson, Eleonor}, year = {2025}, pages = {171--181}, url = {2003093}, language = {swe}, publisher = {Iustus förlag}, keywords = {vin; vinrätt; systembolaget; gårdsförsäljning} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_braccinim_2025, title = {HAIC 2025 - Preface to the First Workshop on Human-AI Collaborative Systems}, author = {Braccini, M. and De Filippo, A. and Milano, M. and Saffiotti, Alessandro and Vallati, M.}, year = {2025}, volume = {4072}, url = {2028998}, language = {eng}, publisher = {Technical University of Aachen}, abstract = {In recent years, Human-AI Collaborative Systems (HAIC) has emerged as a key research frontier, with the aim of leveraging the complementary strengths of humans and artificial intelligence. Research in this area has demonstrated the potential of HAIC systems in a variety of fields, including healthcare, creative arts, finance, manufacturing, and education. These systems not only improve problem-solving and performance, but also enable novel forms of human–machine co-creation and decision-making. The HAIC workshop provides an interdisciplinary forum to explore these challenges and opportunities, fostering dialogue between communities towards a general framework for the design, evaluation and implementation of next-generation human-AI collaborative systems.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sukakulthanisorn_2025, title = {Hand Eczema and Facial Skin Problems - Association with Occupational Exposures among Community Care Personnel in Sweden : A Cross-sectional Study}, author = {Sukakul, Thanisorn and Hamnerius, Nils and Lejding, Tina and Davidson Källberg, Kajsa and Josefson, Anna and Detlofssen, Ebba and Svedman, Cecilia}, year = {2025}, journal = {Acta Dermato-Venereologica}, volume = {105}, doi = {10.2340/actadv.v105.43771}, url = {1990210}, language = {eng}, publisher = {MJS Publishing}, keywords = {hand eczema; face; healthcare personnel; handwashing; contact dermatitis}, abstract = {Hand eczema and facial skin problems are common occupational-related skin diseases. However, the data regarding care workers in community care settings are limited. To assess the prevalence and factors associated with hand eczema and facial skin problems among community care personnel, an online questionnaire link was sent to 10,194 personnel in Sweden, with questions regarding hygiene routines, skin problems, and demographics of the participants. Respondents were categorized into groups regarding their skin symptoms. In all, 1,923 (18.9%) responded (89.8% females; 75.9% assistant nurses and care assistants). The 1-year prevalence of hand eczema and facial skin problems was 34.7% and 45.5%, respectively. Dose-dependent associations were found between occupational exposure to soap and water and hand eczema, and duration of face mask use and facial problems. Also, a higher perceived level of stress, female sex, atopic dermatitis, and lower age group were associated with both hand eczema and facial skin problems. In conclusion, healthcare workers in community care have an increased risk of occupationally related skin symptoms, foremost hand eczema, but also facial symptoms related to the use of face masks. Thus, efforts to reduce the harmful effects from the risk factors should be the main concern.}, issn = {0001-5555} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_shaneimahdi_2025, title = {Harnessing Photon Recoil for Enhanced Torque on Light-Driven Metarotors}, author = {Shanei, Mahdi and Wang, Gan and Johansson, Peter and Volpe, Giovanni and Käll, Mikael}, year = {2025}, journal = {Nano Letters}, volume = {25}, number = {12}, pages = {4832--4837}, doi = {10.1021/acs.nanolett.4c06410}, url = {1942045}, language = {eng}, publisher = {American Chemical Society (ACS)}, keywords = {metasurfaces; microrobots; microrotors; optical force; optical torque}, abstract = {Contact-free rotation of microscopic objects in aqueous environments based on optical forces is a powerful concept in the development of light-driven microrobots, micromachines, torque transducers, and rheological sensors. Here, we demonstrate freely movable quasi-two-dimensional metasurface rotors with lateral dimensions up to 100 μm while still exhibiting controllable and steady rotation when submerged in water. The metarotors utilize photon recoil to produce strong optical torque by deflecting low-intensity laser light toward high angles via long lever arms, which amplify the creation of orbital angular momentum. We find that the torque generated by a single metarotor can be used to rotate hundreds of passive microparticles present in solution, suggesting potential applications as particle mixers in microfluidics and microbiology. Further development might involve utilizing metarotors as components in future microrobots for biomedicine and beyond.}, issn = {1530-6984} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hazrarishi_2025_1, title = {Have Large Language Models Learned to Reason? A Characterization via 3-SAT}, author = {Hazra, Rishi and Venturato, Gabriele and Zuidberg dos Martires, Pedro and De Raedt, Luc}, year = {2025}, url = {2020922}, language = {eng}, keywords = {large language models; reasoning; computational complexity; logic; satisfiability; phase transitions}, abstract = {Large Language Models (LLMs) have been touted as AI models possessing advanced reasoning abilities. In theory, autoregressive LLMs with Chain-of-Thought (CoT) can perform more serial computations to solve complex reasoning tasks. However, recent studies suggest that, despite this capacity, LLMs do not truly learn to reason but instead fit on statistical features. To study the reasoning capabilities in a principled fashion, we adopt a computational theory perspective and propose an experimental protocol centered on 3-SAT -- the prototypical NP-complete problem lying at the core of logical reasoning and constraint satisfaction tasks. Specifically, we examine the phase transitions in random 3-SAT and characterize the reasoning abilities of state-of-the-art LLMs by varying the inherent hardness of the problem instances. By comparing DeepSeek R1 with other LLMs, our findings reveal two key insights (1) LLM accuracy drops significantly on harder instances, suggesting all current models struggle when statistical shortcuts are unavailable (2) Unlike other LLMs, R1 shows signs of having learned the underlying reasoning. Following a principled experimental protocol, our study moves beyond the benchmark-driven evidence often found in LLM reasoning research. Our findings highlight important gaps and suggest clear directions for future research. }, file = {https://oru.diva-portal.org/smash/get/diva2:2020922/FULLTEXT01.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_goncalvesricardo_2025_1, title = {“He plays, and she teaches” : Perspectives of Brazilian children on their teachers in ECEC}, author = {Goncalves, Ricardo and Sales dos Santos, Sandro Vinicius}, year = {2025}, pages = {71--90}, doi = {10.4324/9781003401049-7}, url = {1988164}, language = {eng}, publisher = {Routledge}, abstract = {Our case study presents a Brazilian perspective on children's views of their teachers in early childhood education and care (ECEC), shaped by macro, meso, and micro contexts. On a macro-level, Brazil has made some achievements in educational policies towards gender equality. However, Brazilian society still bears marks from colonialism, where notions of gender are based on heteronormative ideals and binary assumptions, reinforced by the growth of conservative groups. These stereotypical ideas persist in social and political structures, which can be reflected in children's perspectives when interacting with other children and adults in ECEC. On meso and micro-levels, it is evident that children bring stereotyped beliefs from home and can also construct ideas about gender roles in the ECEC. The findings indicate that children notice a slightly gendered division of work when expressing that their male and female teachers have different roles in the group. By recognizing children's agency, the ECEC is configured as a social arena where children can counteract gender stereotypes deeply rooted in Brazilian society. The absence of goal-oriented and systematic pedagogical work becomes apparent when gender is not on the agenda in the ECEC setting. We argue that further discussions about educational policies related to gender in teacher training programs and continuous training for teachers are required to work more systematically and goal-oriented in order to offer children diverse ways of constructing gender in ECEC in Brazil.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_mellinpelle_2025, title = {Health- and environmental aspects of additive manufacturing and challenges for a sustainable production (HÄMAT)}, author = {Mellin, Pelle}, year = {2025}, url = {1980948}, language = {eng}, abstract = {This popular science report presents a short summary of the most important findings and suggestions regarding environment, health and safety (EHS) issues for users of Additive Manufacturing (AM), also known as industrial 3D-printing. The report is based on three different parts of a project (HÄMAT 1-3) that was carried out over the years 2017 - 2024, involving an interdisciplinary network consisting of universities, companies, research institutes as well as non-governmental organizations (HÄMAT websites). The project has been funded by Vinnova and was coordinated by Swerim. The main aim of HÄMAT was to study EHS issues and thereby provide guidance for a well-designed and safe work environment upon establishing this new promising technology. }, file = {https://oru.diva-portal.org/smash/get/diva2:1980948/FULLTEXT01.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_anderzencarlssonagneta_2025, title = {Health and Family Life in Families Where a Parent is Deafblind}, author = {Anderzen-Carlsson, Agneta and Björk, Maria and Huus, Karina and Wahlqvist, Moa}, year = {2025}, pages = {219--227}, doi = {10.1093/oso/9780192887221.003.0020}, url = {2029310}, language = {eng}, publisher = {Oxford University Press}, keywords = {children; deafblindness; family life; parent; partner}, abstract = {Until recently the area of family life when a parent is deafblind has rarely been studied. In this chapter, we discuss findings from the sparse literature on this topic. We will focus on self-rated health, sense of coherence, family climate, and experiences of everyday life of various family members in families where a parent is deafblind, as well as on support needs. The literature shows that all family members are affected by the deafblindness to varying degrees. Thus, all family members should be asked about their individual needs, as well as the needs of the entire family, for professionals to tailor supportive interventions aiming at a healthy life. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lundebergstefan_2025, title = {Health benefits in a cohort of children 6 months after tonsil surgery in relation to the perioperative period : An observational prospective cohort study}, author = {Lundeberg, Stefan and Ericsson, Elisabeth}, year = {2025}, journal = {Health Science Reports}, volume = {8}, number = {1}, doi = {10.1002/hsr2.70364}, url = {1929052}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {glasgow children’s benefit inventory; pain; tonsillectomy; tonsillotomy; health related quality of life}, abstract = {Background and aim: Tonsil-surgery is a common treatment for tonsillitis and upper-airway obstruction. Health benefits are a key point of clinical concern. Aim: To evaluate health benefits 6-months after pediatric tonsil-surgery and to examine the influence of the perioperative period on health related quality of life (HRQoL).Method: Participants, 198 children (4–17 years) who underwent tonsillectomy ± adenoidectomy on infection-related indications (TE±Ainfec, n=46), tonsillectomy ± adenoidectomy due to upper-airway-obstruction (TE±Aobstr, n=44), or tonsillotomy ± adenoidectomy due to upper-airway-obstruction (TT±Aobstr, n=108). Data were collected via a postoperative pain-diary, and 6-month-questionnaires. The Glasgow Children’s Benefit Inventory (GCBI) evaluated HRQoL. An additional questionnaire assessed disease-specific benefits, including open-ended-questions to capture what the children wanted to convey to other children scheduled for surgery. Results: QoL-score after surgery was positive in all  indication/surgical-method groups. The highest GCBI-scores were seen in the subscale-scores for physical health and vitality.  Comparing TE±Aobstr and TT±Aobstr, no significant differences were noted in the total-score or in the subscores. No differences in GCBI-scores were seen between subgroups of patients divided by postoperative pain intensity and duration. No differences in frequency and loudness of snoring or ENT-infections were seen between the groups, and satisfaction rates were high. The information that the children considered essential to share with others covered details of the day of surgery including the anesthesia, nutrition, pain and pain relief, and wellbeing after surgery.Conclusions: All indication/surgical-method groups reported improvements regarding the health benefits of surgery, with the most pronounced effect being seen for physical health and vitality. TE±A and TT±A showed similar benefits in cases of obstructive and infection problems. Postoperative pain had no impact on QoL at the 6-month follow-up. Children’s memories of the surgery can provide direction for management and improvements in children’s care. The pain management needs to be optimized to improve recovery. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_muliirene_2025, title = {Health Care Professionals' Perspectives on Implementing Patient-Accessible Electronic Health Records in Primary Care : Qualitative Study}, author = {Muli, Irene and Cajander, Åsa and Scandurra, Isabella and Hägglund, Maria}, year = {2025}, journal = {JMIR Medical Informatics}, volume = {13}, doi = {10.2196/64982}, url = {1970256}, language = {eng}, publisher = {JMIR Publications}, keywords = {consolidated framework for implementation research; implementation; patient accessible electronic health record; primary care}, abstract = {BACKGROUND: Patients are increasingly being offered online record access (ORA) through patient-accessible electronic health records (PAEHRs), but implementation is often met with resistance from health care professionals (HCPs). Experiences from previous implementations may provide important insights into potential barriers and facilitators. OBJECTIVE: This study aimed to investigate the factors influencing the implementation of the Swedish PAEHR system in primary care from the perspectives of HCPs.METHODS: We conducted 14 semistructured interviews with a diverse group of HCPs shortly after the implementation of the Swedish PAEHR system. The interviews were analyzed using the Consolidated Framework for Implementation Research (CFIR) and content analysis, identifying key themes related to PAEHR implementation.RESULTS: The analysis identified several potential factors influencing the implementation of the Swedish PAEHR system. According to the HCPs, the PAEHR system was flawed but also flexible. The HCPs described working in a complex and imperfect organization, which nonetheless had an existing structure, support, and established communication with patients. They also described nondocumentation-related use of the electronic health record system. Moreover, they reported dealing with a complicated patient group with varying needs and high expectations. The HCPs expressed that they worked in a patient-centered way and with patient engagement. The HCPs could see both the advantages and disadvantages of the PAEHR system and had some concerns. There were mixed views of the extent of the change, where some felt patient ORA would not affect their work at all and others expected a substantial impact. Some HCPs had experience using the PAEHR system themselves, while some lacked knowledge and interest. Furthermore, the implementation process was perceived as long and uneventful, with fragmented communication, where existing communication activities were used. The HCPs also reported receiving some information and education about PAEHRs outside the organization. The HCPs had limited awareness of how patients were introduced to the PAEHR system.CONCLUSIONS: This study underscores the importance of having a usable electronic health record system and addressing organizational issues, such as issues with the work environment, for optimal implementation of eHealth services such as the PAEHR system. It also highlights the importance of HCPs' views and experiences with their patients, and their perceptions and attitudes toward the intervention. Additionally, this study stresses the importance of effective implementation processes and communication strategies for both HCPs and patients.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vareav_2025, title = {Health education in Swedish schools - what's on offer?}, author = {Varea, V. and Caldeborg, Annica and Barker, Dean and Quennerstedt, M.}, year = {2025}, journal = {Scandinavian Journal of Educational Research}, volume = {69}, number = {4}, pages = {871--883}, doi = {10.1080/00313831.2024.2360905}, url = {1868098}, language = {eng}, publisher = {Routledge}, keywords = {health education; sweden; pragmatic discourse analysis; offer}, abstract = {The aim of this paper is to identify the dominant discourses of health and wellbeing that are offered in health education in Swedish schools. Issues of health and wellbeing are covered mainly in four school subjects in Sweden: physical education and health, home and consumer studies, biology, and social studies, and therefore, we interviewed teachers from those subjects to generate data. Six interrelated health discourses were identified from the data. All discourses were, however, also embedded within a health discourse with a comprehensive description of health as physical, psychological and social wellbeing. Results suggest that schools offer a Western and White discourse of health and that some content is overemphasised, and some is missing in relation to other non-dominant discourses of health and wellbeing.}, issn = {0031-3831} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_geidnesusanna_2025, title = {Health Promotion and Sports}, author = {Geidne, Susanna and Ericson, Helena and Quennerstedt, Mikael and Van Hoye, Aurélie}, year = {2025}, doi = {10.1007/978-981-97-0821-5_84-1}, url = {1941311}, language = {eng}, publisher = {Springer Nature}, keywords = {settings-based; organized sports; silos; health promotion; sports}, abstract = {Concepts like public health, health, and health promotion have been used in relation to sports in different ways in practice, research, and policy. That sport is important and closely associated with public health is quite clear. Many research papers claim that there are obvious connections between the value of physical activity and sport for the health of individuals, as well as for health in society. At the same time, promoting public health is one of the main reasons for large governmental funding for sports in many countries. But how can the relation, or rather the relations, between health promotion and sport be understood? This chapter will theorize the relation between health promotion and sports through five categories: (i) health promotion as an outcome of sports, (ii) health promotion through sports, (iii) health promotion in sports, (iv) health promotion and sports in collaboration, and (v) health-promoting sports. In these categories, the authors discuss and illustrate how research in different ways defines health promotion on one hand and sports on the other and, thus, what research takes for granted in relation to what sports can do. The chapter concludes that understanding the relation between health promotion and sports cannot be achieved by focusing exclusively on only one of the identified relations. Instead of maintaining barriers between different disciplines and relations, researchers and practitioners should work with health promotion and sports as the plaster that stabilizes the whole picture in a changing society. This approach can better utilize the potential of sports in promoting health.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karlanderrasmus_2025, title = {Health promotion meets sustainable movement-based education in school - a "walking school" initiative in Sweden}, author = {Karlander, Rasmus and Geidne, Susanna}, year = {2025}, journal = {Health Promotion International}, volume = {40}, number = {1}, doi = {10.1093/heapro/daaf006}, url = {1937965}, language = {eng}, publisher = {Oxford University Press}, keywords = {intervention; outdoor education; participatory; physical activity; settings approach; whole school approach}, abstract = {The World Health Organization states that physical activity has the potential to influence physical, mental, and social dimensions of health in a powerful way. However, in modern society, physical activity is increasingly becoming an active choice, rather than a part of everyday life. Schools have been identified as key settings for health promotion, but physical activity initiatives in schools have rarely had a sustained impact. Interventions have been criticized for seeking to increase levels of physical activity by focusing on individual behaviors rather than considering the contexts and social structures in which individuals live their lives. With a theoretical foundation in settings-based health promotion, this article proposes an alternative initiative for sustainable movement-based education called Walking School. Walking School defines sustainable movement as the movement that is an integral part of the school day and school culture. Walking School, or outdoor teaching while walking, has the potential to (i) be inclusive of both teachers and students, (ii) extend the classroom and make physical activity a collective responsibility of all teachers, not just physical education teachers, (iii) reduce sedentary time and increase physical activity without losing instructional time, (iv) stimulate physical activity and create conditions conducive to the development of new habits by using the outdoor environment as a teaching space, and (5) become part of the school's core business of education, and ultimately a part of the school culture.}, issn = {0957-4824} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_palmandreas_2025, title = {Health Status Instruments Add Prognostic Value in Predicting COPD Exacerbations : Insights from the TIE Cohort Study}, author = {Palm, Andreas and Ellingsen, Jens and Bröms, Kristina and Farkhooy, Amir and Högman, Marieann and Lisspers, Karin and Stallberg, Bjorn and Janson, Christer and Malinovschi, Andrei and Hårdstedt, Maria}, year = {2025}, journal = {COPD: Journal of Chronic Obstructive Pulmonary Disease}, volume = {22}, number = {1}, doi = {10.1080/15412555.2025.2589129}, url = {2022720}, language = {eng}, publisher = {Informa Healthcare}, keywords = {copd exacerbations; health status instruments; mmrc; cat; ccq}, abstract = {Aim: Identifying patients at risk for acute exacerbations of COPD (AECOPDs) is crucial to improve outcomes. We aimed to evaluate the ability of three health status instruments to predict AECOPDs in subjects with and without previous AECOPDs.Methods: A prospective cohort study of COPD patients from primary and outpatient care in three Swedish regions. AECOPDs were retrieved from medical records. The modified Medical Research Council Dyspnoea scale (mMRC), the COPD Assessment Test (CAT), and the Clinical COPD Questionnaire (CCQ) were evaluated. Thresholds for AECOPD prediction were estimated using receiver operator characteristic (ROC) curves. Predictive values were assessed using crude and multivariable Cox regression models.Results: We included 572 patients (59% women, age 69 +/- 8 years, FEV1 57 +/- 18% of predicted) in 2014-2016. All three instruments independently predicted future AECOPDs within three years (adjusted hazard ratio [aHR] 1.5-1.8) using thresholds mMRC >= 2, CAT >= 13, and CCQ >= 1.6. Patients without prior-year AECOPDs but high scores on all instruments had a similar AECOPD risk as those with prior AECOPDs but scores below threshold (aHR 2.4-2.5). Among patients with >= 1 AECOPD the year before inclusion and at least one of the three health status instruments above threshold, the aHR for future AECOPD during the study period ranged from 4.6 to 5.7.Conclusions: mMRC, CAT, and CCQ were independently associated with AECOPDs over the following three-year period. The health status instruments provided additional predictive value for future AECOPDS in patients both with and without previous AECOPDs.Abbreviations: aHR: Adjusted Hazard Ratio; AECOPD: Acute Exacerbations of Chronic Obstructive Pulmonary Disease; AUC: Area Under Curve; BMI: Body Mass Index; CAT: COPD Assessment Test; CCQ: Clinical COPD Questionnaire; COPD: Chronic Obstructive Pulmonary Disease; DAG: Directed Acyclic Graphs; FEV1: Forced Expiratory Volume in 1 Second; FVC: Forced Vital Capacity; GOLD: Global Initiative for Obstructive Lung Disease; HR: Hazard Ratio; IHD: Ischaemic Heart Disease; ICS: Inhaled Corticosteroids; IQR: Interquartile Range; mMRC: Modified Medical Research Council Dyspnoea Scale; ROC: Receiver Operator Characteristic; SD: Standard Deviation; TIE: Tools for Identifying Exacerbations}, issn = {1541-2555} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hommelami_2025, title = {Healthcare professional's management of the risk for postoperative urinary retention in hip surgery patients - a qualitative interview study}, author = {Hommel, Ami and Hummerdal, Nina and Strålöga, Lovisa and Ostaszkiewicz, Joan and Hälleberg Nyman, Maria}, year = {2025}, journal = {International Journal of Orthopaedic and Trauma Nursing}, volume = {57}, doi = {10.1016/j.ijotn.2025.101180}, url = {1954426}, language = {eng}, publisher = {Elsevier}, keywords = {bladder monitoring; guidelines. healthcare professionals; hip surgery; urinary retention}, abstract = {BACKGROUND: Postoperative urine retention can lead to permanent bladder dysfunction. This occurs even though healthcare personnel can access evidence-based guidelines on avoiding urine bladder injuries related to care. AIM: This study aimed to describe healthcare professionals' experiences with, and strategies to avoid post-operative urinary retention among hip surgery patients.METHOD: A descriptive qualitative study using telephone interviews, were conducted in April to June 2021, with 22 healthcare professionals (13 nurses, 7 nursing assistants and 2 occupational therapists) in 17 orthopaedic wards in Sweden. Qualitative content analysis of interview data was performed.RESULTS: Five categories were identified: "Knowledge about guidelines regarding bladder monitoring", "Understanding of patients' prehospital bladder function influences healthcare professionals' reasoning and actions", "Strategies are applied to make it easier for the patients to empty their bladder", "Indwelling catheter is used routinely" and "Short length of stay creates stress".CONCLUSION: To optimise safe patient bladder monitoring after hip surgery, health care professionals need to be more aware of the availability of guidelines about bladder monitoring to adopt consistent monitoring practices, and to have enough time to care for patients.}, issn = {1878-1241} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ryenlinda_2025, title = {Healthcare resource utilization and production loss in vedolizumab-treated inflammatory bowel disease patients : results from the Swedish prospective multicentre SVEAH study}, author = {Ryen, Linda and Visuri, Isabella and Karlqvist, Sara and Malmgren, Carolina and Bergemalm, Daniel and Eriksson, Carl}, year = {2025}, journal = {Therapeutic Advances in Gastroenterology}, volume = {18}, doi = {10.1177/17562848251352023}, url = {1986545}, language = {eng}, publisher = {Sage Publications}, keywords = {crohn's disease; healthcare resource utilization; inflammatory bowel disease; ulcerative colitis; vedolizumab}, abstract = {Background: Data on direct and indirect annual costs for inflammatory bowel disease (IBD) patients treated with vedolizumab are limited.Objectives: To evaluate the total annual direct healthcare costs and indirect costs among IBD patients treated with vedolizumab.Design: A prospective observational multicentre study involving 286 patients with Crohn's disease (CD; n = 169) or ulcerative colitis (UC; n = 117) who started vedolizumab therapy during 2015-2017 at 21 hospitals across Sweden.Methods: Data on direct and indirect costs were collected during a 3-year follow-up period. Direct costs were measured as healthcare resource utilization including medication, hospital admissions and hospital-based outpatient visits. Indirect societal costs were measured as production losses from sick leave and disability pension. Data were obtained from the Swedish Quality Register for IBD and through linkage with national registers. Data are presented both for patients who continued treatment throughout the follow-up period and for patients who discontinued treatment (CD: n = 83; UC: n = 48).Results: The mean annual direct follow-up cost was <euro>24,305 for all IBD patients, <euro>24,873 for CD patients and <euro>23,484 for UC patients (p = 0.24). No difference was observed between men and women (<euro>24,506 vs <euro>24,080; p = 0.87). Direct costs were similar in patients who continued vedolizumab for the entire study period (<euro>24,401) and those who discontinued treatment (<euro>24,192; p = 0.12). Medication was the primary driver of direct costs (64%), followed by hospital admissions (19%) and outpatient care (17%). Mean indirect costs were lower among patients who continued vedolizumab (<euro>3044) than among those who stopped the treatment (<euro>8927; p < 0.01). Increased direct costs were associated with perianal disease and high baseline disease activity in CD, and concurrent use of immunomodulators in UC.Conclusion: Patients treated with vedolizumab in Swedish clinical practice represent a group with high direct costs, primarily due to medication expenses. However, indirect costs were significantly lower than in previous reports.}, issn = {1756-283X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_chirehevin_2025, title = {Healthcare, school and daily life experiences of patients with microphthalmia or anophthalmia and their parents}, author = {Chireh, Evin and Nordquist, Jonas and Andersson Grönlund, Marita and Fahnehjelm, Kristina Teär}, year = {2025}, journal = {Acta Paediatrica}, volume = {114}, number = {3}, pages = {619--627}, doi = {10.1111/apa.17484}, url = {1910403}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {anophthalmia; microphthalmia; qualitative study; thematic analysis}, abstract = {AIM: This qualitative study explored the lived experiences of the patients with microphthalmia and anophthalmia and their parents, focusing on the healthcare, school settings and daily life challenges to improve patient management.METHODS: In-depth interviews were conducted in Stockholm, Sweden, from October 2022 to June 2023. Participants were recruited through the St Erik Eye Hospital database (2008-2022), and the data was analysed using reflexive thematic analysis.RESULTS: The study included 15 patients (9 female and 6 male), with a median age of 21 years (range 15-31), and 1 parent per patient. Five key themes were identified from the parental interviews and three from the patient interviews. Both groups emphasised the need for improvements in healthcare, including better physician continuity, emotional support, information provision and prosthesis functionality. Families of those with severe bilateral visual impairment highlighted the need for additional school and daily life support. While some parents had future concerns, most patients viewed their condition as a natural part of life.CONCLUSION: Patients and parents shared insights on the psychosocial impact and suggested improvements in the healthcare and school settings, providing valuable guidance for enhancing care and management for this patient group.}, issn = {0803-5253} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_swahnjohan_2025, title = {Healthier if vegan in a bowl : Label and tableware of a vegetarian meal are associated with healthiness in a restaurant}, author = {Swahn, Johan and Pettersson, Nicklas and Andrén, Daniela and Baptista, Iuri and Öström, Åsa}, year = {2025}, journal = {International Journal of Gastronomy and Food Science}, volume = {41}, doi = {10.1016/j.ijgfs.2025.101264}, url = {1995001}, language = {eng}, publisher = {Elsevier}, keywords = {consumer science; sensory analysis; foodservice; labels; tableware; plant-based}, abstract = {In the pursuit of more sustainable and healthier diets, it is important to understand how the presentation and description of vegetarian meals can affect consumers' preferences and perceptions. This study investigated the influence of two tablewares (bowl and plate) and two labels ("vegan" and "plant-based") on liking, willingness to pay, and perceptions of healthiness and sustainability of a vegetarian meal in a restaurant located in the headquarters of a retail company in Stockholm, Sweden. It was found that participants perceived the meal as healthier when it was served in a bowl or labeled "vegan" than when it was served on a plate or labeled "plantbased", and no other significant association between tableware or label and other measured variables was found. These results can help researchers, restaurants, cafeterias, pastry shops, and industries understand and communicate better with consumers about healthier and more sustainable vegetarian meals. Further studies should include other food products and participants from other cultural backgrounds, as well as measure choice and intake.}, issn = {1878-450X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hearnjeff_2025_3, title = {Hegemonic digitalisation in policy on older people : The Finnish case and wider social implications}, author = {Hearn, Jeff and Niemistö, Charlotta and Sjögren, Hanna}, year = {2025}, journal = {Sociological Review}, doi = {10.1177/00380261251397300}, url = {2028214}, language = {eng}, publisher = {Sage Publications}, keywords = {ageing; digitalisation; hegemonic digitalisation; older people; policy}, abstract = {This article brings together societal debates on digitalisation and analysis of governmental policy on older people, through the theoretical frame of hegemonic digitalisation, and the empirical case of Finnish policy. With changing demographics in many countries, old age has gained high-profile focus in governmental policy in recent years, which has in turn become increasingly constructed in relation to digitalisation, often via an interventionist logic that positions new technologies as solutions to problems of ageing. In this analysis, material-discursive power relations are highlighted, with policy understood as material-discursive in its formation, form and effects. Specifically, the article critically examines: the conceptualisation of hegemonic digitalisation, often assumed, even across political differences, as an efficient solution to declining resources within neoliberal governance, with reference to policy on/and older people; how digitalisation and older people are constructed in governmental policy documents in Finland; and the applicability of hegemonic digitalisation to Finnish policy on older people. The article concludes with discussion of the implications that follow for everyday life, policy, social analysis and social theory. Regarding theoretical implications, with hegemonic digitalisation, the hegemony of digitalisation is emphasised, as in national policy contexts, rather than whole-society or global hegemony seen as digital. Additionally, tensions persist between foregrounding hegemonic digitalisation, and the co-constitution of older people and digitalisation policy. Specificities of ageing and older age impinge on and present challenges for both analysis of digitalisation and social theory. Theorising materiality-discursivity is a fertile perspective for studies on age, policy and digitalisation, including how future-orientation figures in policy and research.}, issn = {0038-0261}, file = {https://oru.diva-portal.org/smash/get/diva2:2028214/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hofmannrobin_2025, title = {Helicobacter pylori Screening After Acute Myocardial Infarction : The Cluster Randomized Crossover HELP-MI SWEDEHEART Trial}, author = {Hofmann, Robin and James, Stefan and Sundqvist, Martin O. and Wärme, Jonatan and Angerås, Oskar and Alfredsson, Joakim and Erlinge, David and Arefalk, Gabriel and Arstad, Göran and Blomberg, Simon and Fröbert, Ole and Hambraeus, Kristina and Hellström, Per M. and Lauermann, Jörg and Lidin, Matthias and Lindhagen, Lars and Mourtzinis, Georgios and Schoede, Carolina and Thunström, Erik and Voldberg, Birgitta and Wagner, Henrik and Östlund, Ollie and Jernberg, Tomas and Bäck, Magnus}, year = {2025}, journal = {Journal of the American Medical Association (JAMA)}, volume = {334}, number = {13}, doi = {10.1001/jama.2025.15047}, url = {1994558}, language = {eng}, publisher = {American Medical Association (AMA)}, abstract = {IMPORTANCE: Upper gastrointestinal bleeding is common after myocardial infarction.OBJECTIVE: To determine whether routine screening for Helicobacter pylori infection during hospitalization for myocardial infarction reduces bleeding events and improves clinical outcomes.DESIGN, SETTING, AND PARTICIPANTS: A nationwide, open-label, 2-period, 2-sequence, cluster randomized, crossover clinical trial using a clinical registry for study population definition and data collection merged with national Swedish health data registries. From November 17, 2021, through January 17, 2024, thirty-five Swedish hospitals grouped into 18 clusters were randomized to a sequence of 1 year with routine H pylori screening of all patients with acute myocardial infarction followed by a washout period of 2 months before crossing over to 1 year with usual care or vice versa. Patients were followed up until January 17, 2025.INTERVENTION: Routine addition of H pylori screening by urea breath test to standard care in all patients hospitalized for myocardial infarction during the screening periods.MAIN OUTCOME AND MEASURE: Upper gastrointestinal bleeding, analyzed by a negative binomial model in the intention-to-treat population.RESULTS: A total of 18 466 patients (median age, 71 years [IQR, 61-79], 13 138 males [71%]) with myocardial infarction were followed up: 9245 during the screening periods and 9221 during the nonscreening periods. At admission, 2284 during the screening periods and 2275 during the nonscreening periods (both 24.7%) reported proton pump inhibitor use. During screening periods, 6480 patients (70%) had undergone testing, of those 1532 (23.6%) tested positive for H pylori. After a median follow-up of 1.9 years, 299 patients in the screening group (incidence rate, 16.8 events per 1000 person-years; cumulative hazard at 3 years, 4.1%) and 336 in the usual care group (incidence rate, 19.2 events per 1000 person-years; cumulative hazard at 3 years, 4.6%) experienced the primary end point of upper gastrointestinal bleeding (rate ratio [RR], 0.90; 95% CI, 0.77-1.05; P = .18). Predefined nonmultiplicity adjusted subgroup analyses showed a heterogeneous intervention effect; for no anemia (RR, 0.98; 95% CI, 0.80-1.21), mild anemia (RR, 0.64; 95% CI, 0.42-0.98), and moderate to severe anemia (RR, 0.44; 95% CI, 0.23-0.87; P for interaction = .03).CONCLUSIONS AND RELEVANCE: Among unselected patients with acute myocardial infarction, routine H pylori screening did not significantly reduce the risk of upper gastrointestinal bleeding.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05024864.}, issn = {0098-7484} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hofmannrobin_2025_1, title = {HELicobacter Pylori screening to prevent gastrointestinal bleeding in patients with acute Myocardial Infarction(HELP-MI SWEDEHEART) - Design and rationale of a cluster randomized, crossover, registry-based clinical trial}, author = {Hofmann, Robin and James, Stefan and Sundqvist, Martin O. and Wärme, Jonatan and Fröbert, Ole and Angerås, Oskar and Hellström, Per M. and Hambraeus, Kristina and Alfredsson, Joakim and Erlinge, David and Lauermann, Jörg and Lindhagen, Lars and Östlund, Ollie and Jernberg, Tomas and Bäck, Magnus}, year = {2025}, journal = {American Heart Journal}, volume = {26}, pages = {66--74}, doi = {10.1016/j.ahj.2025.03.014}, url = {1948524}, language = {eng}, publisher = {Elsevier}, keywords = {cluster randomized crossover trial; helicobacter pylori; myocardial infarction; randomized registry-based clinical trial; upper gastrointestinal bleeding}, abstract = {BACKGROUND: The role of Helicobacter pylori (H. pylori) screening and eradication on reducing upper gastrointestinal bleeding (UGIB) complications after acute myocardial infarction (MI) is uncertain. The HELicobacter Pylori screening to prevent gastrointestinal bleeding in patients with acute MI (HELP-MI SWEDEHEART) trial aims to determine whether systematic H. pylori screening compared to usual care reduces UGIB, mortality, and cardiovascular outcomes after MI.METHODS: A cluster randomized, crossover, registry-based clinical trial using SWEDEHEART as trial platform for study population definition and source for data collection in combination with nationwide Swedish health data registries. Thirty-five Swedish hospitals, organized into 18 clusters based on percutaneous coronary intervention networks, were randomized to either routine H. pylori screening for adults with acute type-1 MI or usual care. After one year, a 2-month blanking period was followed by a crossover to the alternate allocation for one year. The trial enrolment was concluded after one additional year of registry-based follow-up. The primary endpoint is UGIB. Secondary endpoints include all-cause death, cardiovascular death, readmission for MI, stroke, or heart failure. Endpoints will be reported combined (Net Adverse Clinical Events; Major Adverse Cardiac or Cerebrovascular Events) and separately. The primary analysis will include all available follow-up time corresponding to a maximum follow-up time of 3 years and 2 months.CONCLUSION: HELP-MI SWEDEHEART aims to determine the utility of routine H. pylori screening to reduce UGIB and improve cardiovascular outcomes after MI. By integrating national registry follow-up data with a pragmatic trial design, it has the potential to provide evidence for the effect of the implementation of routine H. pylori screening as part of acute MI care.TRIAL REGISTRATION: ClinicalTrials.gov, NCT05024864.}, issn = {0002-8703} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_claessonlingehallhelena_2025, title = {Hemodynamic control during cardiopulmonary bypass and the incidence of postoperative delirium- a post hoc analysis}, author = {Claesson Lingehall, Helena and Olofsson, Birgitta and Gustafson, Yngve and Wahba, Alexander and Appelblad, Micael and Svenmarker, Staffan}, year = {2025}, journal = {BMC Anesthesiology}, volume = {25}, number = {1}, doi = {10.1186/s12871-025-03141-8}, url = {1965684}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {delirium; postoperative delirium; neurological complication; postoperative cognitive complications; cardiac surgery; cardiopulmonary bypass}, abstract = {Background: Delirium is a common neurological complication after cardiac surgery. The purpose of the present study was to analyze the association between hemodynamic fluctuations during cardiopulmonary bypass (CPB) and the incidence of postoperative delirium (POD) in patients undergoing cardiac surgery with CPB.Methods: This post hoc analysis included one-hundred-ninety-five (n = 195) patients aged >= 65 years of whom seventy (n = 70) patients developed POD. Intraoperative hemodynamic variables specifically related to the conduct of CPB were digitally recorded at 1-minute intervals. Variables outside the presumed safe boundaries for mean arterial pressure (MAP), systemic perfusion flow index- L/min/BSA (QBSA(I)), systemic venous oxygen saturation (SVO2) and arterial oxygen delivery- ml/min/BSA (DO2) were defined and analyzed with reference to indices of area under the curve (AUC) and the relative proportion of registrations related to POD. POD was diagnosed according to DSM-5 criteria based on a test battery performed preoperatively and repeated twice postoperatively. Statistical tests used to verify observations outside the predefined norm included the Mann-Whitney U test and the chi-squared test.Results: Markers of hemodynamic control during CPB showed significant associations with POD. Both DO2 (P = 0.02) and QBSA(I) (P < 0.001) identified POD patients outside the predefined upper and lower safety limits. SVO2 values > 84% (P < 0.001) werealso associated with the development of POD. The number of SVO2 registrations below the lower safety limit was negligible, why statistical analysis seemed not useful. No association between MAP and POD registrations was identified.Conclusions: This study revealed a clear association between markers of hemodynamic control and POD. These associations were most pronounced for DO2 and QBSA(I). The detected association between high SVO2 and POD warrants further insight.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_aregbedevictor_2025_1, title = {Here's your PDDL Problem File! On Using VLMs for Generating Symbolic PDDL Problem Files}, author = {Aregbede, Victor and Forte, Paolo and Gupta, Himanshu and Andreasson, Henrik and Köckemann, Uwe and Lilienthal, Achim J.}, year = {2025}, pages = {4455--4461}, doi = {10.1109/ICRA55743.2025.11127832}, url = {2023120}, language = {eng}, publisher = {IEEE}, abstract = {Large Language Models (LLMs) excel at generating contextually relevant text but lack logical reasoning abilities. They rely on statistical patterns rather than logical inference, making them unreliable for structured decision-making. Integrating LLMs with task planning can address this limitation by combining their natural language understanding with the precise, goal-oriented reasoning of planners. This paper introduces ViPlan, a hybrid system that leverages Vision Language Models (VLMs) to extract high-level semantic information from visual and textual inputs while integrating classical planners for logical reasoning. ViPlan utilizes VLMs to generate syntactically correct and semantically meaningful PDDL problem files from images and natural language instructions, which are then processed by a task planner to generate an executable plan. The entire process is embedded within a behavior tree framework, enhancing efficiency, reactivity, replanning, modularity, and flexibility. The generation and planning capabilities of ViPlan are empirically evaluated with simulated and real-world experiments.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tabrizifara_2025, title = {Heritability and polygenic load for comorbid anxiety and depression}, author = {Tabrizi, Fara and Rosén, Jörgen and Grönvall, Hampus and William-Olsson, Victor Rahimzadeh and Arner, Erik and Magnusson, Patrik Ke and Palm, Camilla and Larsson, Henrik and Viktorin, Alexander and Bernhardsson, Jens and Björkdahl, Johanna and Jansson, Billy and Sundin, Örjan and Zhou, Xuan and Speed, Doug and Åhs, Fredrik}, year = {2025}, journal = {Translational Psychiatry}, volume = {15}, number = {1}, doi = {10.1038/s41398-025-03325-3}, url = {1948192}, language = {eng}, publisher = {Springer Nature}, abstract = {Anxiety and depression commonly occur together resulting in worse health outcomes than when they occur in isolation. We aimed to determine whether the genetic liability for comorbid anxiety and depression was greater than when anxiety or depression occurred alone. Data from 12,792 genotyped twins (ages 38-85) were analysed, including 1,986 complete monozygotic and 1,594 complete dizygotic pairs. Outcomes were prescription of antidepressant and anxiolytic drugs, as defined by the World Health Organization Anatomical Therapeutic Chemical Classification System (ATC) convention, for comorbid anxiety and depression (n = 1028), anxiety only (n = 718), and depression only (n = 484). Heritability of each outcome was estimated using twin modelling, and the influence of common genetic variation was assessed from polygenic scores (PGS) for depressive symptoms, anxiety, and 40 other traits. Heritability of comorbid anxiety and depression was 79% compared with 41% for anxiety and 50% for depression alone. The PGS for depressive symptoms likewise predicted more variation in comorbid anxiety and depression (adjusted odds ratio per SD PGS = 1.53, 95% CI = 1.43-1.63; ΔR2 = 0.031, ΔAUC = 0.044) than the other outcomes, with nearly identical results when comorbid anxiety and depression was defined by International Classification of Diseases (ICD) diagnoses (adjusted odds ratio per SD PGS = 1.70, 95% CI = 1.53-1.90; ΔR2 = 0.036, ΔAUC = 0.051). Individuals in the highest decile of PGS for depressive symptoms had over 5 times higher odds of being prescribed medication for comorbid anxiety and depression compared to those in the lowest decile. While results on a predominant role of depressive symptoms may have been biased by the size and heterogeneity of available data bases, they are consistent with the conclusion that genetic factors explain substantially more variation in comorbid anxiety and depression than anxiety or depression alone.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bageriushenric_2025_2, title = {Heterosexualiteten – en modern uppfinning}, author = {Bagerius, Henric}, year = {2025}, journal = {Nerikes Allehanda}, number = {16 december}, pages = {6--7}, url = {2026848}, language = {swe}, publisher = {Nerikes allehanda AB}, issn = {1103-971X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindkvistgustav_2025, title = {HFD 2024 ref. 52 - vilken betydelse har påstådd skatteplanering för ombudsersättningsreglerna?}, author = {Lindkvist, Gustav}, year = {2025}, journal = {Svensk skattetidning}, volume = {2}, pages = {153--159}, url = {2022345}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatteprocess}, issn = {0346-2218} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindkvistgustav_2025_1, title = {HFD 2025 ref. 13 - fåmansföretagarpresumtion på utgiftssidan}, author = {Lindkvist, Gustav}, year = {2025}, journal = {Svensk skattetidning}, volume = {4}, pages = {334--347}, url = {2022355}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatteprocess}, issn = {0346-2218} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_16, title = {HFD : kupongbeskattning av utdelning till KEVA stred mot EU-rätten}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031715}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 10 december meddelades Högsta förvaltningsdomstolens dom HFD 2024 ref 63. I domen konstaterades uttag av kupongskatt från den finska pensionsanstalten KEVA strida mot den fria rörligheten för kapital. Professor Eleonor Kristoffersson kommenterar domen.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_17, title = {HFD : träningsplattform var inte tillhandahållande av idrottstjänst}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031691}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 24 april 2025 kom Högsta förvaltningsdomstolens dom i mål nr 6553-24 om mervärdesbeskattning av tillhandahållande av en abonnemangstjänst i form av en internetbaserad träningsplattform. Eleonor Kristoffersson, professor i skatterätt, analyserar domen.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_18, title = {HFD undanröjer förhandsbesked om beskattning av stiftelses värdepappershandel}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031781}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Skatterättsnämnden har i ett förhandsbesked kommit fram till att en stiftelse inte skulle bedriva värdepappersrörelse, och således inte skulle beskattas i inkomstslaget näringsverksamhet när den bedrev faktorinvestering. Högsta förvaltningsdomstolen har den 20 december 2024 i HFD 2024 not. 76 undanröjt förhandsbeskedet. Professor Eleonor Kristoffersson kommenterar Högsta förvaltningsdomstolens avgörande.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_rudenkoandrey_2025, title = {Hierarchical System to Predict Human Motion and Intentions for Efficient and Safe Human-Robot Interaction in Industrial Environments}, author = {Rudenko, Andrey and Zhu, Yufei and Almeida, Tiago Rodrigues de and Schreiter, Tim and Castri, Luca and Belotto, Nicola and Linder, Timm and Vaskevicius, Narunas and Palmieri, Luigi and Magnusson, Martin and Lilienthal, Achim J.}, year = {2025}, url = {1941552}, language = {eng}, abstract = {In this paper we present a hierarchical motion and intent prediction system prototype, designed to efficiently operate in complex environments while safely handling risks arising from diverse and uncertain human motion and activities. Our system uses an array of advanced cues to describe human motion and activities, including generalized motion patterns, full-body poses, heterogeneous agent types and causal contextual factors that influence human behavior.}, file = {https://oru.diva-portal.org/smash/get/diva2:1941552/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_yuanjuan_2025, title = {HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma}, author = {Yuan, Juan and Maitra, Subhamita and Antoniou, Eirini and Zhu, Jiacheng and Li, Wenyu and Demirel, Ilknur Safak and Toskas, Kostantinos and Martinez, Iria Laura and Ozcimen, Lacin and Lindehell, Henrik and Muhr, Jonas and Stenman, Jakob and Kogner, Per and Bedoya Reina, Oscar and Schlisio, Susanne and Holmberg, Johan}, year = {2025}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, volume = {122}, number = {43}, doi = {10.1073/pnas.2516922122}, url = {2008098}, language = {eng}, publisher = {Proceedings of the National Academy of Sciences (PNAS)}, keywords = {hif2α; mycn; neuroblastoma; noradrenergic differentiation; tumor suppression}, abstract = {The role of HIF2α, encoded by EPAS1, in neuroblastoma remains controversial. Here, we demonstrate that induction of high levels of HIF2α in MYCN-amplified neuroblastoma cells results in a rapid and profound reduction of the oncoprotein MYCN. This is followed by an upregulation of genes characteristic of noradrenergic cells in the adrenal medulla. Additionally, upon induction of HIF2α, the proliferation rate drops substantially, and cells develop elongated neurite-like protrusions, indicative of differentiation. In vivo HIF2α induction in established xenografts significantly attenuates tumor growth. Notably, analysis of sequenced neuroblastoma patient samples, revealed a negative correlation between EPAS1 and MYCN expression and a strong positive correlation between EPAS1 expression, high expression levels of noradrenergic markers, and improved patient outcome. This was paralleled by analysis of human developing adrenal medulla datasets wherein EPAS1 expression was prominent in populations with high expression levels of genes characteristic of noradrenergic chromaffin cells. Our findings show that high levels of HIF2α in neuroblastoma, leads to drastically reduced MYCN protein levels, cell cycle exit, and noradrenergic cell differentiation. Taken together, our results challenge the dogma that HIF2α acts as an oncogene in neuroblastoma.}, issn = {0027-8424} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_matogamitchm_2025, title = {High prevalence of Haemophilus ducreyi among patients with suspected primary syphilis in Malawi, 2019-2022}, author = {Matoga, Mitch M. and Chen, Jane S. and Seña, Arlene C. and Ndalama, Beatrice and Nyirenda, Naomi and Bonongwe, Naomi and Mathiya, Esther and Kamtambe, Blessings and Jere, Edward and Banda, Gabriel and Thengolose, Isaac and Coelho, Jenny and Hennelly, Christopher M. and Schröder, Daniel and Unemo, Magnus and Salazar, Juan and Radolf, Justin D. and Parr, Jonathan and Hoffman, Irving F.}, year = {2025}, journal = {Clinical Infectious Diseases}, doi = {10.1093/cid/ciaf114}, url = {1946276}, language = {eng}, publisher = {University of Chicago Press}, keywords = {haemophilus ducreyi; genital ulcer disease; malawi; chancroid; darkfield microscopy; syphilis}, abstract = {BACKGROUND: As syphilis rates have increased globally, chancroid has dramatically declined as a cause of genital ulcer disease (GUD).METHODS: We recruited patients ≥18 years presenting to an STI clinic with GUD from Lilongwe, Malawi from November 2019 - April 2022. Lesion exudates were tested by darkfield microscopy (DFM) and polymerase chain reaction (PCR) for Treponema pallidum (TP), and by PCR for Haemophilus ducreyi (HD), herpes simplex virus (HSV) and Chlamydia trachomatis (CT). We evaluated the sensitivity and specificity of DFM relative to TP PCR, the distribution of GUD etiologies by PCR, and the performance of our HD PCR relative to Allplex Genital Ulcer assay (Seegene Inc) using the Cohen's kappa statistic.RESULTS: We enrolled 568 participants; the median age was 27 years (interquartile range: 23, 34), 61% (345/564) were men, and 13% (60/464) were living with HIV or newly diagnosed with HIV. DFM identified TP in 55 (10%) of participants, with a sensitivity and specificity of 12% and 94%, respectively. PCR identified TP in 367 (65%), HD in 128 (23%), HSV in 98 (17%), and CT in 36 (6%) of participants with only 1/36 (2.8%) with serovar L1, L2 or L3 consistent with lymphogranuloma venereum; no etiology was identified in 48 (8%). External validation confirmed the high HD prevalence (Cohen's kappa 0.78, 89% agreement).CONCLUSION: Syphilis and chancroid are common etiologies of GUD in Malawi. Our findings underscore the value of highly sensitive molecular diagnostic methods to periodically assess GUD causes among STI patients in countries using syndromic management.}, issn = {1058-4838} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fverholmtherese_2025, title = {High proportion of depression and anxiety in younger patients with COPD : a cross-sectional study in primary care in Sweden}, author = {Öfverholm, Therese and Hasselgren, Mikael and Lisspers, Karin and Nager, Anna and Eliason, Gabriella and Giezeman, Maaike and Janson, Christer and Kisiel, Marta A. and Montgomery, Scott and Ställberg, Björn and Sundh, Josefin and Sandelowsky, Hanna}, year = {2025}, journal = {Scandinavian Journal of Primary Health Care}, doi = {10.1080/02813432.2025.2526667}, url = {1982359}, language = {eng}, publisher = {Taylor & Francis}, keywords = {copd; anxiety; depression; early copd; observational studies; primary health care}, abstract = {BACKGROUND AND AIM: Patients with COPD and concurrent depression and/or anxiety are known to have an increased risk of exacerbations, morbidity, mortality, and deteriorated quality of life. Early detection of depression/anxiety may enable early interventions. The aims of this study were to describe the occurrence of depression and anxiety in primary care patients with COPD in Sweden, and to investigate age and gender differences together with other clinical factors associated with this comorbidity.METHODS: A cross-sectional study was performed on a cohort of patients with doctor's diagnoses of COPD. Patients were randomly selected based on the patients' contact with 98 primary healthcare centers and 13 hospitals in Sweden in 2014. Information about self-reported depression/anxiety, patient characteristics, symptoms, and comorbidity, were collected using patient self-completion questionnaires. Lung function data were extracted from medical records.RESULTS: Of the 2245 patients recruited, 23% (n = 524) reported depression/anxiety, 29% in women and 16% in men (p <0.001). Factors associated with depression/anxiety were being a woman (OR = 2.06 [95% CI 1.56-2.72]), current smoking (1.83 [1.37-2.43]), comorbid asthma (1.77 [1.32-2.37]), dyspnea (the modified Medical Research Council dyspnea scale ≥2 points) (1.58 [1.17-2.13]) and age <65 years (1.57 [1.17-2.10]). The youngest age groups had the highest proportions of patients with depression/anxiety.CONCLUSIONS: Healthcare professionals need to be particularly aware of depression/anxiety in patients with COPD who are younger, women, current smokers, have comorbid asthma, or dyspnea.}, issn = {0281-3432} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jacobssonsusanne_2025_1, title = {High susceptibility to the novel antimicrobial zoliflodacin among Neisseria gonorrhoeae isolates in eight WHO Enhanced Gonococcal Antimicrobial Surveillance Programme countries in three WHO regions, 2021-2024}, author = {Jacobsson, Susanne and Cherdtrakulkiat, Thitima and Golparian, Daniel and Heng, Lon Say and Hoffman, Irving and Jamoralin, Manuel C. and Kakooza, Francis and Kittiyaowamarn, Rossaphorn and Kyambadde, Peter and Lan, Pham Thi and Maseko, Venessa and Matoga, Mitch and Müller, Etienne and Nguyen, Thuy Thi Phan and Ouk, Vichea and Schröder, Daniel and Setiawaty, Vivi and Sia, Sonia B. and Sulaiman, Verawati and Virak, Mot and Van, Nguyen Thi Thuy and Maatouk, Ismael and Wi, Teodora and Unemo, Magnus}, year = {2025}, journal = {IJID Regions}, volume = {15}, doi = {10.1016/j.ijregi.2025.100624}, url = {1954884}, language = {eng}, publisher = {Elsevier}, keywords = {gonorrhea; in vitro susceptibility; neisseria gonorrhoeae; treatment; who egasp; zoliflodacin}, abstract = {OBJECTIVES: Zoliflodacin, a novel spiropyrimidinetrione, showed non-inferiority compared with recommended ceftriaxone plus azithromycin treatment in a recent global phase III randomized controlled trial for gonorrhea treatment. We evaluated the susceptibility of zoliflodacin among 2993 contemporary gonococcal isolates collected in 2021-2024 in eight World Health Organization (WHO) Enhanced Gonococcal Antimicrobial Surveillance Programme countries in the WHO Southeast Asian Region (Indonesia, Thailand), WHO Western Pacific Region (Cambodia, the Philippines, Viet Nam), and WHO African Region (Malawi, South Africa, Uganda).METHODS: Minimum inhibitory concentrations (MICs) of zoliflodacin were determined using the agar dilution technique, and the zoliflodacin target gene (gyrB) was examined with Illumina sequencing.RESULTS: Zoliflodacin exhibited high activity: MICs ranging from 0.001 to 1 mg/l and a modal MIC of 0.032 mg/l. The zoliflodacin MIC distribution showed mostly a wild-type profile; however, two isolates from Cambodia had MICs of 0.5 mg/l and 1 mg/l. These isolates also harbored the GyrB D429N mutation, associated with increased zoliflodacin MICs.CONCLUSIONS: We show a high susceptibility to zoliflodacin internationally, including against ceftriaxone- and azithromycin-resistant gonococcal strains. Our findings support the continued clinical development of zoliflodacin as a treatment for gonorrhea, although cautious and monitored introduction and continuous international resistance surveillance are imperative.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wennerstentherese_2025, title = {Higher socioeconomic status is associated with dispensation of monoclonal antibodies against calcitonin gene-related peptide in migraine : A nested case-control study}, author = {Wennersten, Therese and Lindh, Jonatan D. and Nilsson Remahl, A Ingela M and Andersson, Marine L. and von Euler, Mia and Wirdefeldt, Karin and Ekheden, Isabella}, year = {2025}, journal = {Cephalalgia}, volume = {45}, number = {6}, doi = {10.1177/03331024251348648}, url = {1972229}, language = {eng}, publisher = {Sage Publications}, keywords = {cgrp monoclonal antibodies; migraine; socioeconomic status}, abstract = {Background: Higher socioeconomic status (SES) among people with migraine has been associated with an increased use of triptans, but it is undetermined whether high SES is also associated with dispensation of monoclonal antibodies against calcitonin gene-related peptide (CGRPi), a prophylactic treatment against migraine episodes. Our hypothesis was that higher SES is associated with CGRPi dispensation, although the association is expected to be attenuated in a country that generally allows for reimbursement of CGRPi costs.Methods: In this register-based nested case-control study, the association between SES, categorized into three levels (low, middle and high) and the outcome of a first dispensation of a CGRPi was assessed among people with a migraine diagnosis in Region Stockholm, using univariable and multivariable logistic regression models.Results: Of 52,996 individuals in the study population, 3.2% (n = 1674) were dispensed CGRPi. Individuals with high or middle SES had an increased probability of being dispensed CGRPi, compared to individuals with low SES (adjusted odds ratio = 1.68; 95% confidence interval = 1.46-1.92 and adjusted odds ratio = 1.41; 95% confidence interval = 1.24-1.61, respectively).Conclusions: Higher SES was associated with dispensation of CGRPi, which suggests unequal access to CGRPi.}, issn = {0333-1024} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_anderssonpernilla_2025_1, title = {Hippocampal and prefrontal GABA and glutamate concentration contribute to component processes of working memory in aging}, author = {Andersson, Pernilla and Li, Xin and Persson, Jonas}, year = {2025}, journal = {Cerebral Cortex}, volume = {35}, number = {5}, doi = {10.1093/cercor/bhaf105}, url = {1957695}, language = {eng}, publisher = {Oxford University Press}, keywords = {gaba; aging; glutamate; spectroscopy; working memory}, abstract = {Both animal and human studies indicate that individual variation in the neurometabolites gamma-aminobutyric acid and glutamate is linked to cognitive function. Age-related differences in these neurometabolites could potentially explain lower cognitive ability in older age. Working memory-the capacity to hold a limited amount of information online for a short period-has a central role in cognition, and this ability is also impaired in older individuals. Here, we investigated the relationship between gamma-aminobutyric acid (GABA+) levels and a composite measure of glutamate/glutamine (Glx) in the hippocampus and inferior frontal gyrus (IFG) and how these neurochemical markers relate to working memory in younger and older adults. Across age groups, we found a significant positive association between working memory accuracy and Glx in the IFG, as well as a significant negative association between GABA+ in this region and proactive interference. Age-stratified analyses demonstrated significant positive associations between components of working memory and hippocampal/IFG Glx, as well as a significant negative association between IFG GABA+ and proactive interference in older adults only. These results provide novel evidence for a specific involvement of excitatory Glx and working memory accuracy as well as inhibitory GABA+ for control of proactive interference in working memory, and how these effects are differentially affected by age.}, issn = {1047-3211} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hultkajsa_2025, title = {Hipster Hospitality : The Paradox of Accessibility and Exclusivity in Contemporary Food Culture}, author = {Hult, Kajsa}, year = {2025}, url = {1998111}, language = {eng}, abstract = {Elite status in the gastronomic sector has traditionally been associated with fine dining. However, in recent years, a new form of elite food discourse has emerged within hipster restaurants. Host-guest interactions in these spaces embody a paradox, simultaneously embracing ideals of accessibility and exclusivity. Research shows that while these venues position themselves as inclusive and community-driven, they subtly maintain elite status through aesthetic values, symbolic meanings, and service practices. This phenomenon reveals how exclusivity operates within seemingly accessible food spaces, catering to individuals who share similar cultural understandings of food. Drawing on ethnographic research and cultural analysis, this study examines how hipster restaurant venues both challenge and reinforce social hierarchies, offering an ambivalent form of democratization. On one hand, they reject traditional fine dining markers such as rigid service scripts and perfectionist craftsmanship. On the other, they cultivate new forms of distinction based on social taste and aesthetic sensibilities. Despite their casual and welcoming appearance, hipster food spaces, such as artisanal coffee shops, natural wine bars, and neo-bistros, maintain elite status through leisure service and particular taste regimes. Paradoxically, professionals in these settings frame their work as inclusive and democratic, contrasting with broader discourses on food democracy, where inclusivity and accessibility are emphasized. This study contributes to discussions on hipster hospitality as both a democratic and elite phenomenon. By interrogating the intersection of elite and contemporary food cultures within hospitality, it explores how the amplification of certain voices shapes the legitimacy and desirability of food spaces while marginalizing others. Situating hipster hospitality within broader debates on media and food democracy, this research highlights the tensions between inclusion and exclusion in contemporary food discourse.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sunj_2025, title = {Histologic remission and major adverse cardiovascular events in patients with inflammatory bowel disease : a nationwide cohort study}, author = {Sun, J. and Marild, K. and Sundström, J. and Bergman, D. and Ebrahimi, F. and Halfvarson, Jonas and Olen, O. and Ludvigsson, J.}, year = {2025}, journal = {European Heart Journal}, volume = {46}, number = {Suppl. 1}, doi = {10.1093/eurheartj/ehaf784.1075}, url = {2037877}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background: Inflammatory bowel disease (IBD) is associated with cardiovascular diseases (CVDs). However, the impact of histologic and clinical activity on this association remains unclear.Methods: We conducted a nationwide cohort study in Sweden involving 59,168 IBD patients diagnosed in 1969-2017 with histologic evaluation (i.e., histologic inflammation vs. remission) and 91,800 patients diagnosed in 1969-2020 with assessment of clinical activity (i.e., clinically active vs. quiescent IBD) in 2006-2021, followed until 31 December 2021. The primary outcome was incident major adverse cardiovascular events (MACE), a composite outcome encompassing ischemic heart disease (myocardial infarction), stroke (hemorrhagic or ischemic stroke), and heart failure. Cox proportional hazards model was applied to estimate adjusted hazard ratios (aHRs) of MACE and its subcomponents within 2 years after documented histologic inflammation (vs. remission) or clinically active IBD (vs. quiescent IBD).Results: An increased 2-year risk of MACE was observed after histologic inflammation (n=868, incidence rate [IR]: 86.3/10,000 person-years) than after remission (n=558, IR=71.3), corresponding to one extra MACE per 331 IBD patients over 2 years after histologic inflammation (aHR=1.16 [95%CI: 1.04 to 1.30]). This excess risk was similar in CD (aHR=1.30 [1.03 to 1.64]) and UC (aHR=1.13 [1.01 to 1.27]). Histological inflammation was associated with an increased risk of ischemic heart disease (aHR=1.16 [1.00 to 1.34]), myocardial infarction (aHR=1.36 [1.12 to 1.64]), ischemic stroke (aHR=1.31 [1.06 to 1.62]), and heart failure (aHR=1.35 [1.15 to 1.60]), but not significantly so for hemorrhagic stroke (aHR=1.22 [0.80 to 1.85]). Compared to quiescent IBD, clinically active IBD was also significantly related to increased risks of MACE (IR: 131.4 vs. 93.7 per 10,000 person-years; aHR=1.54 [1.46 to 1.63]) as well as its subcomponents. Even in patients with clinically quiescent IBD, histologic inflammation was associated with an increased risk of myocardial infarction (aHR=1.29 [1.06 to 1.58]) and heart failure (aHR=1.19 [1.00 to 1.43]).Conclusion: Histologic and clinical activity of IBD were associated with an increased MACE, including myocardial infarction, ischemic stroke, and heart failure. These findings suggest that improved disease control could provide opportunities to reduce MACE risk in IBD.}, issn = {0195-668X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sunjiangwei_2025_1, title = {Histologic remission and mortality in patients with inflammatory bowel disease : a nationwide cohort study}, author = {Sun, Jiangwei and Mårild, Karl and Bergman, David and Ebrahimi, Fahim and Halfvarson, Jonas and Olén, Ola and Ludvigsson, Jonas F.}, year = {2025}, journal = {Clinical Gastroenterology and Hepatology}, doi = {10.1016/j.cgh.2025.10.030}, url = {2014082}, language = {eng}, publisher = {Elsevier}, keywords = {inflammatory bowel disease; clinical activity; cohort; histologic inflammation; mortality}, abstract = {BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) is associated with increased mortality risk. However, whether this risk is influenced by histologic and clinical activity remains uncertain.METHODS: A nationwide cohort study in Sweden. We compared mortality rates linked to histologic inflammation in 63,358 patients diagnosed with IBD 1969-2017 and to clinical activity in 102,352 patients diagnosed 1969-2020. The adjusted hazard ratio (aHR) of mortality within 2 years after index date (i.e., date of histologic/clinical activity) was estimated using cause-specific hazard model, with 95% confidence intervals (CIs).RESULTS: A higher 2-year all-cause mortality was observed after histologic inflammation than after histologic remission (incidence rates [IRs]: 121.0 vs. 64.8 per 10,000 person-years; aHR=1.45; 95%CI: 1.30 to 1.61). This excess risk was observed in all IBD subtypes: Crohn's disease (aHR=1.42 [1.16 to 1.73]), ulcerative colitis (aHR=1.44 [1.26 to 1.65]), and IBD-unclassified (aHR=1.56 [1.01 to 2.41]). Clinically active IBD was also associated with an increased 2-year all-cause mortality compared to quiescent IBD (IR: 352.6 vs. 106.3 per 10,000 person-years; aHR=3.35 [3.21 to 3.49]). Even in patients with clinically quiescent IBD, histologic inflammation was associated with an increased 2-year all-cause mortality (aHR=1.42 [1.08 to 1.87]).CONCLUSIONS: Both histologic inflammation and clinical activity of IBD were associated with increased all-cause mortality, suggesting that improved disease control may reduce mortality risk in IBD.}, issn = {1542-3565} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ohaganlaurenalex_2025_5, title = {Historicizing the marketing of plant-based meat substitutes : a multimodal analysis of Sanitas Nut Food Company advertisements, 1896-1901}, author = {O’Hagan, Lauren Alex and Eriksson, Göran}, year = {2025}, journal = {Food and Foodways}, volume = {33}, number = {2}, pages = {103--130}, doi = {10.1080/07409710.2025.2482483}, url = {1951157}, language = {eng}, publisher = {Routledge}, keywords = {advertisements; john harvey kellogg; meat myths; meat substitutes; social semiotics}, abstract = {This paper historicizes the contemporary meat substitutes trend by analyzing advertisements from the Sanitas Nut Food Company, founded by Dr John Harvey Kellogg, during its first five years of operation (1896-1901). Using visual social semiotics, it explores the rhetorical and multimodal strategies used in the advertisements, finding that Sanitas marketed its meat substitute products by drawing upon four meat myths-normal, natural, necessary, and nice-often using shockvertising to promote dietary change. However, by focusing on meat's taste, flavor, appearance, and nutritional benefits, Sanitas unintentionally perpetuated meat's superiority, undermining the significance of meat substitutes in their own right. Today, the persistence of similar strategies, though adapted to reflect contemporary societal values, highlights the need for marketing that prioritizes consumer education and animal agriculture issues. These findings emphasize the enduring influence of certain ways of shaping "eating knowledge" around meat and our material interactions with food.}, issn = {0740-9710} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wistrandsten_2025_1, title = {Hjalmar Bergmans kluvenhet}, author = {Wistrand, Sten}, year = {2025}, journal = {Axess}, number = {7}, pages = {58--61}, url = {2007882}, language = {swe}, publisher = {Axess publishing}, keywords = {hjalmar bergman; modernitet; funktionalismen; radioteater}, issn = {1651-0941} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_iannottamarco_2025, title = {Holding Form in a Shifting World : Flexible and Reliable Robot Manipulation through Behavior Trees}, author = {Iannotta, Marco}, year = {2025}, url = {2002317}, language = {eng}, publisher = {Örebro University}, abstract = {The increasing complexity and unpredictability of manipulation tasks in modern industrial and service robotics have highlighted the limitations of pre-programmed robot solutions. Robots operating under changing object positions, variable obstacles, and unforeseen perturbations must adjust their actions online to reliably satisfy the high-performance requirements of real-world deployment scenarios.A promising direction for enabling such flexible and reliable manipulation lies in the use of Behavior Trees (BTs), a formalism for transparent decision-making that structures robot behavior hierarchically through modular, reusable components. BTs are a well-suited solution because their inherent reactivity allows the system to respond effectively to high-level disturbances, such as perception or grasping failures. At the same time, their modular design facilitates the reuse of sub-behaviors across different scenarios, enabling automation systems to be easily reconfigured to meet varying operational demands. However, existing BT-based approaches fall short in scenarios in which more advanced forms of robustness to local perturbations and task variations are required. This thesis contributes novel solutions to address these limitations and enhance the applicability of BTs as control policies in real-world manipulation settings.To rigorously assess the solutions proposed in this thesis, we first need to formalize the terminology and evaluation criteria associated with BT-based robot control. We begin by identifying a subset of properties that are most relevant to our scope, such as reactivity, modularity, and robustness, and clarifying their definitions by resolving ambiguities found in prior work. For each of these properties, we examine how they have been evaluated in the literature and propose additional metrics to address identified gaps in existing evaluation practices.The first technical contribution addresses the reactivity of BT policies and their way of handling simultaneous control objectives. While BTs effectivel ymanage global, high-level disturbances, flexible manipulation also requires rapid response to local, low-level perturbations that do not warrant changes to the high-level plan. Furthermore, when BTs are coupled with convention allow-level controllers for redundant manipulators, they often struggle to satisfy multiple, potentially competing objectives in a coherent and reliable manner. To address these limitations, we integrate BTs with a prioritized control strategy that decomposes each manipulation skill, such as grasping, into multiple control objectives with defined priorities, distributed across the BT nodes and executed concurrently. This integration introduces an additional layer of low-level reactivity, ensures the reliable satisfaction of multiple objectives, and reinforces the modularity of the BT policy by assigning distinct goals to separate leaf nodes.Although the proposed framework provides robustness to both high- and low-level disturbances during execution, it still relies on manually specified parameters, which often need adjustment to specific task variations, such as minor changes of object positions or obstacle configurations. The second technical contribution is a data-driven approach based on Reinforcement Learning that augments the BT with a context-based adaptation policy. This module observes task-relevant features, referred to as a context, and selects appropriate BT parameters at execution time. The result is a policy that adapts its behavior on the fly to previously unseen variations, without manual intervention.Despite its benefits, the proposed framework remains limited to adapting only to directly observable task variations and requires training procedures that, when performed on a physical robot, are often unsafe and timeconsuming. The last technical contribution addresses both limitations by introducing a context estimator that infers latent dynamics parameters — such as friction coefficients or object mass — from recent interaction data. Conditioning the context-based adaptation policy on this latent estimate enables the BT-based policy to operate robustly even under partial observability. Moreover, because these latent parameters often underlie the discrepancies between simulation and reality, the very same mechanism also provides a principled way to bridge the sim-to-real gap: policies are trained in simulation with domain randomization, while the estimated context compensates for the mismatched dynamics, improving robustness at deployment.}, file = {https://oru.diva-portal.org/smash/get/diva2:2002317/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisioannis_2025_1, title = {Holistic approaches in systemic lupus erythematosus : do physicians avoid addressing difficult-to-treat but highly relevant symptoms?}, author = {Parodis, Ioannis and Wincup, Chris and Touma, Zahi and Andersen, Jeanette and Strand, Vibeke and Sjöwall, Christopher}, year = {2025}, journal = {RMD Open}, volume = {11}, number = {1}, doi = {10.1136/rmdopen-2024-005400}, url = {1943179}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {health-related quality of life; lupus erythematosus; systemic; patient reported outcome measures; treatment}, abstract = {Despite advancements in the management of systemic lupus erythematosus (SLE), patients experience poor health-related quality of life (hrQoL) and premature death due to disease severity and treatment side effects. Achieving remission offers substantial benefits, including improved hrQoL and reduced mortality, yet the complexity of SLE, with its diverse underlying immune mechanisms and clinical manifestations, hampers progress. Involvement of the central nervous system with symptoms like fatigue, pain and brain fog often goes unaddressed due to limited evidence-based guidance and measurement tools. This neglect reflects gaps in training, discomfort in addressing untreatable symptoms and an overemphasis on evidence-based medicine, compromising holistic care. Recognising patient-reported outcomes has shifted SLE care towards a more patient-centred model, addressing hrQoL and aligning treatment goals. Embracing this approach and prioritising symptom management, even when a definitive cure is lacking, ensures compassionate, comprehensive care that improves adherence, satisfaction and the overall lived experience of patients with SLE.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tolgforsbjrn_2025_2, title = {Holistic assessment in school physical education : ‘Seeing the whole picture with our trained eye’}, author = {Tolgfors, Björn and Caldeborg, Annica and Jansson, Karl and Mustell, Jan and Sjödin, Karin and Barker, Dean}, year = {2025}, journal = {European Physical Education Review}, doi = {10.1177/1356336x251380095}, url = {2002047}, language = {eng}, publisher = {Sage Publications}, keywords = {policy enactment; educational reform; summative assessment; grading; performativity; autonomy}, abstract = {This article focuses on teachers’ responsiveness to changes in assessment policy and how new guidelines affect assessment and grading practices in school physical education (PE). The previous national curriculum in Sweden directed many teachers towards an atomistic approach to assessment.The reformed guidelines, in contrast, mandate that teachers should strive for holistic assessment.Thus, the purpose of this study was to generate an understanding of how teachers interpret and translate the policy for holistic PE assessment and discuss potential consequences of their policyenactments. Data were generated through six focus group interviews with 22 PE teachers working at different secondary and upper secondary schools. The theoretical framework usedin the analysis is based on Ball et al.’s (2012a) work on policy enactment. The findings show that teachers view the policy for holistic assessment in PE positively. They claim that it enables them to concentrate on the bigger picture, weigh factors in terms of significance during assessment, and connect to students’ lives outside of PE. We discuss the potential consequences ofthe teachers’ policy enactments in terms of the backwash of the reform. On the one hand, the reform results in reduced transparency and a risk that certain areas of knowledge may be marginalised. On the other hand, the study suggests that teachers’ autonomy with respect to assessment increases. This autonomy, which ideally leads to valid holistic assessments and fair grades, is tailored to the students’ conditions and what they see as meaningful knowledge in life outside ofschool.}, issn = {1356-336X}, file = {https://oru.diva-portal.org/smash/get/diva2:2002047/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gemzelldanielssonkristina_2025, title = {Home use of mifepristone for medical abortion : a systematic review}, author = {Gemzell-Danielsson, Kristina and Lindh, Ingela and Brynhildsen, Jan and Christensson, Anna and Moberg, Klas and Wernersson, Emma and Johansson, Susanne}, year = {2025}, journal = {BMJ Sexual & Reproductive Health}, volume = {51}, number = {3}, pages = {221--231}, doi = {10.1136/bmjsrh-2024-202302}, url = {1904722}, language = {eng}, publisher = {BMJ Books}, keywords = {abortifacient agents; mifepristone; abortion}, abstract = {BACKGROUND: In many countries, persons seeking medical abortion with mifepristone followed by misoprostol can self-administer the second drug, misoprostol, at home, but self-administration of the first drug, mifepristone, is not allowed to the same extent.OBJECTIVES: This systematic review aims to evaluate whether the efficacy, safety and women's satisfaction with abortion treatment are affected when mifepristone is self-administered at home instead of in a clinic.SEARCH STRATEGY: A literature search covered CINAHL, Cochrane Library, Embase, Ovid MEDLINE and APA PsycInfo in October 2022.SELECTION CRITERIA: Eligible studies focused on persons undergoing medical abortion comparing home and in-clinic mifepristone intake. Outcomes included abortion effectiveness, compliance, acceptability, and practical consequences for women.DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed eligibility and risk of bias. Meta-analysis included similar studies while those differing in design were synthesised without meta-analysis.RESULTS: Six studies (54 233 women) of medical abortions up to 10 weeks were included. One randomised controlled trial and one retrospective register study had moderate risk of bias, and four non-randomised clinical trials where women could choose the place for intake of mifepristone had serious risk of bias. There was no difference in abortion effectiveness (high confidence) or compliance (moderate confidence) between mifepristone administered at home or in-clinic. No differences in complications were detected between groups and most women who chose home administration of mifepristone expressed a preference for this approach.CONCLUSIONS: Our systematic review demonstrates that the effectiveness of medical abortion is comparable regardless of mifepristone administration and intake, at home or in the clinic.}, issn = {2515-1991} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_oeserclarissa_2025, title = {Home-based self-collection of biological samples, including vaginal swabs : a mixed methods study for Britain's fourth National Survey of Sexual Attitudes and Lifestyles (Natsal-4)}, author = {Oeser, Clarissa and Sonnenberg, Pam and Unemo, Magnus and Sadler, Katharine and Clifton, Soazig and Gibbs, Jo and Beddows, Simon and Hamilton, Rebecca and Roodt, Abraham and Migchelsen, Stephanie and Dema, Emily and David, Alexandra and Mercer, Catherine H. and Field, Nigel}, year = {2025}, journal = {Sexually Transmitted Infections}, volume = {101}, number = {4}, pages = {252--255}, doi = {10.1136/sextrans-2024-056386}, url = {1926493}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {communicable diseases; diagnostic techniques and procedures; infection; population surveillance; sexual health}, abstract = {OBJECTIVES: The decennial National Surveys of Sexual Attitudes and Lifestyles (Natsal) provide general population prevalence estimates in Britain for key sexually transmitted infections (STIs) through biosampling. Since methodological choices can impact acceptability and response rates, we evaluated processes for Natsal-4, including face-to-face and remote interview arrangements, non-return of test results and vaginal swab collection in two pilot studies.METHODS: The pilots were conducted during June to August 2021 and February to March 2022. Participants aged 16-59 years were invited to provide urine samples (cisgender men and trans/gender diverse) or three vaginal swabs (cisgender women; urine was requested if vaginal swabs were declined) following interview. Samples were self-collected at home and posted to the laboratory by the interviewer if the interview was face to face, or by the participant if they preferred to collect the sample later or the interview was remote. Process feedback was collected after the first pilot via qualitative interviews with participants and after both pilots through informal interviewer debriefing.RESULTS: Of 261 participants interviewed (pilot 1=130; pilot 2=131), 161 (62%) consented to biosampling, of which 129 (49%) provided samples. A sample was received from 78/153 (51%) of women, of whom 60 (77%) provided vaginal swabs and 18 (23%) provided a urine sample. A urine sample was received from 51/108 (47%) cisgender men or trans/gender diverse participants. All samples collected immediately after face-to-face interviews were received (n=77), while 64% of samples from participants consenting to post samples after face-to-face interviews and 60% after remote interviews were received. Process feedback confirmed our methods were broadly acceptable.CONCLUSIONS: We demonstrated that our approach to biosampling and STI testing for a national sexual health survey was reasonably acceptable and feasible in the period coming out the COVID-19 pandemic. Self-collection of vaginal swabs for research, which provide higher testing sensitivity than urine, was feasible and acceptable in a home setting.}, issn = {1368-4973} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_babrimaira_2025, title = {Homo Academicus as Becoming Nomad : Reflections Through a Journey of Pregnancy and Motherhood}, author = {Babri, Maira}, year = {2025}, pages = {137--160}, doi = {10.1007/978-3-031-58195-3_7}, url = {1947961}, language = {eng}, publisher = {Palgrave Macmillan}, keywords = {interpersonal ethics; motherhood; nomadism; braidotti; neoliberal; other}, abstract = {This chapter builds on personal experiences and reflections of a transition from a static scholarly position toward a freer, self-acceptingly different, academic positionality of the Nomad. I share how my experiences during pregnancy and early motherhood catalyzed a transition in my academic identity. Exploring my journey as a reflection over my past and my becoming self, I start from a positionality as embedded but on the margins of the dominant and rational ideal academic, accepting a marginalized space for myself as a woman academic. Drawing inspiration from Braidotti’s Nomadic Subject and Nomadic Ethics, I work through awkward encounters which occurred because I so blatantly no longer fit the mold. Through reflection of these encounters between the dominant logic and that which did not fit, I share the story of how I construct an identity as Academic Nomad, both rooted and on the move, and in becoming.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_schellcarlotto_2025, title = {Hospital burden of critical illness across global settings : a point prevalence and cohort study in Malawi, Sri Lanka and Sweden}, author = {Schell, Carl Otto and Kayambankadzanja, Raphael Kazidule and Beane, Abi and Wellhagen, Andreas and Kodippily, Chamira and Hvarfner, Anna and Banda, Grace and Jegathesan, Nalayini and Hintze, Christoffer and Wijesiriwardana, Wageesha and Gerdin Wärnberg, Martin and Sujeewa, Jayasingha Arachchilage and Kachingwe, Mtisunge and Bjurling-Sjöberg, Petronella and Mbingwani, Isaac and Kalibwe Mkandawire, Annie and Sjöstedt, Hampus and Kumwenda-Mwafulirwa, Wezzie and Rajendra, Surenthirakumaran and Dzinjalamala, Odala Kamandani and Lundborg, Cecilia Stalsby and Mndolo, Kwazizira Samson and Lipcsey, Miklós and Haniffa, Rashan and Kurland, Lisa and Castegren, Markus and Baker, Tim}, year = {2025}, journal = {BMJ Global Health}, volume = {10}, number = {3}, doi = {10.1136/bmjgh-2024-017119}, url = {1947962}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {health policies and all other topics; health services research; infections; diseases; disorders; injuries}, abstract = {INTRODUCTION: The burden of critical illness may have been underestimated. Previous analyses have used data from intensive care units (ICUs) only, and there is a lack of evidence about where in hospitals critically ill patients receive care. This study aims to determine the burden of critical illness among adult inpatients across hospitals in different global settings.METHODS: We performed a prospective, observational, hospital-based, point prevalence and cohort study in countries of different socioeconomic levels: Malawi, Sri Lanka and Sweden. On specific days, all adult in-patients in the eight study hospitals were examined by the study team for the presence of critical illness and followed up for hospital mortality. Patients with at least one severely deranged vital sign were classified as critically ill. The primary outcomes were the presence of critical illness and 30-day hospital mortality. In addition, we determined where the critically ill patients were being cared for and the association between critical illness and 30-day hospital mortality.RESULTS: Among 3652 hospitalised patients, we found a point prevalence of critical illness of 12.0% (95% CI 11.0 to 13.1), with a hospital mortality of 18.7% (95% CI 15.3 to 22.6). The crude OR of death of critically ill patients compared with non-critically ill patients was 7.5 (95% CI 5.4 to 10.2). Of the critically ill patients, 96.1% (95% CI 93.9 to 97.6) were cared for in the general wards outside ICUs.CONCLUSIONS: The study has revealed a substantial burden of critical illness in hospitals from different global settings. One in eight hospital in-patients was critically ill, 19% of the critically ill died in hospital, and 96% of the critically ill patients were cared for outside of ICUs. Implementing the most feasible and low-cost critical care in general wards throughout hospitals would impact a large number of high-risk patients and has the potential to improve outcomes across all acute care specialties.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_almqvistroland_2025, title = {How accounting continues : 25 years of building a management control infrastructure in a Swedish municipality}, author = {Almqvist, Roland and Wällstedt, Niklas}, year = {2025}, journal = {Journal of Public Budgeting, Accounting and Financial Management}, volume = {37}, number = {6}, pages = {103--128}, doi = {10.1108/jpbafm-09-2023-0162}, url = {1954418}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {control infrastructure; how accounting continues; practices of strategizing; longitudinal study}, abstract = {Purpose: This paper follows how a Swedish municipality builds their management control infrastructure over 25 years – from the early 1990s to the middle of the 2010s; complemented by a revisit in 2023. The analysis builds on Power’s (2015) framework on “how accounting begins.” As such, it will show the process in which objects such as quality, competence, fairness and economy (1) start their journey as abstract policy objects – promises or dreams, but also as problems – that should be achieved by the municipal organization; (2) begin to take on more concrete forms as they become elaborated, activities are orchestrated and an increasingly stable infrastructure is built around them and (3) achieve multiplicity in ways that make the daily work of practitioners highly complex, leading them to engage in strategizing. This makes accounting continue: once this long and arduous process is worked through, when the infrastructure has stabilized, and the strategizing behavior is learned, this three-step process moves much faster.Design/methodology/approach: This study is a longitudinal case study over 25 years in one municipal organization: the city of Stockholm – capital of Sweden. We begin in 1991, which is the approximate start of a shift in Stockholm from an old public administration model (Hood, 1991) toward NPM, and we end in 2016, with a post script 2023, when this shift has proceeded into something slightly new and different. Our research engagement with the city of Stockholm has been long-standing: since the early 1990s, we have been conducting five larger research projects on different aspects of management control (for example, the introduction of competition or the decentralization reform) and we have had continuous exchange with city officials and co-workers through workshops and participative observations. For the purpose of this study, we focus on the data from the five research projects and the reading of all budget documents and annual reports from 1991 to 2016.Findings: The findings extend the framework by Power (2015) in a way that helps us understand how accounting continues. Accounting continues for three interrelated reasons: (1) because of the foundational work that is done over a long time, and according to Power’s (2015) model, where objects such as quality, competence and economy go from existing in abstract programmatic forms to more concrete technological ones around which activities can be orchestrated and where exercises involving learning and collaboration are key. (2) Because such learning and collaboration allow practitioners – professionals and accountants – to engage in strategizing the system in different ways that make it functional. Such strategizing can be argued to be part of the broader infrastructure – not only the “highways” but also the shortcuts and scenic detours are part of it. (3) Because such strategizing makes top managers and politicians think that the system works in rather unproblematic ways – they never see the struggles that go on “the lower levels” of organization. The argument of this paper is that the focus on the outside world and the interest to extend the system by incorporating more and more objects in programmatic forms that we see on the political level in the third period is a sign of further diffusion by accounting: because the system seems to work so well, it can be extended to new parts of the world. And this is how accounting continues.Research limitations/implications: From the empirical data, we have derived three periods, which can be seen as three phases of building the infrastructure. We see these periods as struggles to gain knowledge about what the organization should provide and an ongoing engagement to build an infrastructure that would support the delivery of the identified objects quality, economy, fairness and competence. These periods could, of course, be divided in different ways. However, as we interpreted the patterns in our data, this dividing of the data seemed reasonable.Practical implications: In the first chapter of their book, Lapsley and Miller (2024, p. 4) provide a quote from 1983 by an NPM proponent. This proponent depicted the old public administration model, which institutions like, e.g. the NHS, were built upon, as “‘a mobile’: designed to move with every breath of air, but which infact never changes its position and gives no clear indication of direction.” Exactly the same thing can be said about the NPM-related infrastructure we have analyzed. Funck and Karlsson (2023) are obviously right when they argue that proponents of post-NPM movements echo the concerns of NPM proponents “back in the days.” We add to this by arguing that NPM has become what it was supposed to replace: a directionless mobile, maintaining status quo while allowing for strategic behavior (Caffrey et al., 2019). What we learn from NPM’s early days is that no “radical rethinking” (Parker et al., 2023) or “imaginaries” (Funck and Karlsson, 2023) can change this: what is needed, for a real paradigm shift, is the introduction of new problems and new experimentation on the practical level. What remains, both from a practical and academic point of view, would be to discuss what constitutes “enough experimentation”? What can be introduced today that is as disruptive as the introduction of, e.g. tender documents, purchaser/provider models, profit units, etc. during the implementation of NPM? These questions might have to be answered – otherwise accounting will continue to perform as is.Originality/value: We believe a relevant contribution with the paper is the longitudinal character of the method.}, issn = {1096-3367}, file = {https://oru.diva-portal.org/smash/get/diva2:1954418/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_baptistaiuri_2025, title = {How can consumer science help the foodservice industry replace meat? A critical review}, author = {Baptista, Iuri and Garnett, Emma and Öström, Åsa}, year = {2025}, journal = {Appetite}, volume = {207}, doi = {10.1016/j.appet.2025.107861}, url = {1927815}, language = {eng}, publisher = {Elsevier}, keywords = {consumer behavior; habit-changing; interventions; protein transition; vegetarianism}, abstract = {In the pursuit of more sustainable diets, researchers have been studying ways to promote a transition from animal- to plant-based meals in foodservice contexts by influencing participants' conscious choices through names, labels, claims, and information. This critical review found that these interventions usually mobilize only those already engaged in reducing the consumption of animal products and often only during the intervention period, failing to influence those who eat most meat or to create long-lasting effects. Analyzing the choice for vegetarian meals against meals with meat in recently published studies conducted in foodservice contexts, we argue that the transition to more sustainable diets should rely less on consumers' willpower and more on public policies and institutional measures that change the availability, price, and visibility of plant-based meals. Inspired by behavioral sciences, this paper discusses interventions that challenge meals with meat as the default option and suggests hybrids as a path to increase the availability, convenience, and sensory familiarity of vegetarian meals. The paper ends with proposals for questions, interventions, metrics, and issues to be researched by consumer science, including questions on the degree of freedom of consumers' choice and what would be the ethical limits to telling half the truth about hybrids.}, issn = {0195-6663}, file = {https://oru.diva-portal.org/smash/get/diva2:1927815/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rezvanizeinab_2025, title = {How consumers’ emotions about transport policies shape their adoption of sustainable transport}, author = {Rezvani, Zeinab and Sohn, Stefanie and Jansson, Johan and Schnittka, Oliver}, year = {2025}, journal = {International Journal of Sustainable Transportation}, volume = {19}, number = {7}, pages = {587--596}, doi = {10.1080/15568318.2025.2510414}, url = {1959600}, language = {eng}, publisher = {Taylor & Francis}, keywords = {sustainable transport; transport policy; emotional acceptance; alternative fuel vehicles; policy support; consumer}, abstract = {Policymakers are increasingly implementing transport policies to encourage sustainable transport behaviors. However, research on how these policies influence the adoption of sustainable transport remains limited, particularly from the individual consumer’s perspective. This study examines how consumers’ emotional acceptance of transport policies—specifically, the anticipated pride and guilt-relief associated with the policies shape their intention to adopt sustainable transport. Using the case of Sweden’s environmental transport policy aimed at achieving fossil fuel independence by 2030, we surveyed 342 adults and analyzed the data using structural equation modeling. Our findings reveal that emotional acceptance of the policy significantly increases the likelihood of adopting sustainable trans-port (i.e. willingness to adopt an alternative fuel vehicle). Policy-related emotions enhance individuals’ perceptions of the policy’s effectiveness and foster greater support, which in turn promotes the adoption of sustainable transport options. These insights offer valuable guidance for policymakers: by complementing structural measures (such as subsidies and infrastructure investments) with communication strategies that evoke positive emotional responses, it is possible to strengthen public support for environmental transport policies and accelerate the uptake of sustainable transport.}, issn = {1556-8318} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bckstrmdenise_2025, title = {How do I implement a whole blood program with low blood wastage?}, author = {Bäckström, Denise and Fagerlund, Malin Jonsson and Larsson, Stella and Alshamari, Aseel and Henningsson, Ragnar and Holst, Karin and Harstad, Anna-Maria and Lubenow, Norbert and Folatre, José-Gabriel Sato and Carlbom, Pia Remneberg and Wikman, Agneta}, year = {2025}, journal = {Transfusion}, volume = {65}, number = {11}, pages = {2014--2020}, doi = {10.1111/trf.18402}, url = {1996313}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {blood center operations; blood component preparations; blood management}, abstract = {BACKGROUND: The use of low-titer O whole blood (LTOWB) is requested in the treatment of major bleeding, initially used in military medicine but now increasingly utilized in civilian prehospital care. The advantage is the administration of a balanced transfusion, red blood cells, coagulation factors, and platelets, in one bag. The challenges are the availability of LTOWB and difficulties in predicting the need in major bleeding, leading to the risk of wastage.METHODS: This study describes different logistical strategies when implementing whole blood in the Swedish civilian healthcare. The five transfusion centers producing whole blood in Sweden participated, providing experience of the production line, usage, and wastage.RESULTS: In Sweden, LTOWB is used prehospital in helicopter emergency medical service (HEMS), in one physician-manned rapid response vehicle, and inhospital in three University Hospitals. The logistical strategies to reduce wastage vary but involve the rotation of LTOWB not used prehospital to inhospital use in two centers and the preparation of red blood cell (RBC) units from 1 to 2 weeks old LTOWB in three centers. The number of transfused LTOWB units varies between the centers, and wastage was 0%-13% in 4/5 centers and higher in one center, 34%.CONCLUSION: It is difficult to predict the need of LTOWB, requested in prehospital emergencies. Aiming for low wastage requires different logistical chains, depending on the local prerequisites. In Sweden, LTOWB is either rotated for use in major bleeding in hospital or prepared to RBC units after 1 week prehospital.}, issn = {0041-1132} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindstedtkatarina_2025, title = {How do your genes feel? A qualitative investigation of subjective experience of anorexia nervosa in patients with high vs. low polygenic risk}, author = {Lindstedt, Katarina and Monell, Elin and Birgegård, Andreas and Bulik, Cynthia M. and Termorshuizen, Jet D. and Clinton, David}, year = {2025}, journal = {Psychiatric Genetics}, volume = {35}, number = {4}, pages = {96--106}, doi = {10.1097/YPG.0000000000000395}, url = {1959271}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, keywords = {anorexia nervosa; experiential genetics; polygenic risk; qualitative research; subjective experiences}, abstract = {OBJECTIVE: Genome-wide association studies (GWAS) implicate psychiatric, metabolic, and anthropometric factors in anorexia nervosa. We developed an 'experiential genetics' design, layering qualitative methodology atop GWAS to capture the subjective experience of anorexia nervosa.METHOD: We randomly selected GWAS participants with anorexia nervosa from the highest (n = 10) and lowest (n = 10) anorexia nervosa polygenic risk scores (PRS). Clinicians blind to PRS group conducted semi-structured interviews exploring the perception of symptoms, onset, course, and physical and psychological experience of negative energy balance (NEB) (i.e. the pathognomonic anorexia nervosa symptom of expending more energy than one consumes). Blind raters rated transcripts; experiential themes and subthemes were identified through thematic analysis.RESULTS: Themes indicated that the high-PRS group reported more lifetime psychiatric problems, described the descent into anorexia nervosa as a purposeful progression of preexisting preoccupations, experienced NEB as more positive and energizing, and were more often symptomatic at interview; for them anorexia nervosa seemed to represent the apex of a life trajectory centered on eating disorder traits and symptoms. The low-PRS group reported fewer lifetime psychiatric problems, a more environmentally determined illness onset, fewer extreme symptoms, and were less symptomatic at interview; for them anorexia nervosa seemed to constitute a transient interruption of their life trajectory. Interviewers correctly guessed group membership less frequently than chance (43%), questioning whether the dimensions commonly associated with anorexia nervosa capture the genetic essence of anorexia nervosa.CONCLUSION: Qualitative research can capture the phenotypic expression of genetic risk, enrich GWAS, characterize heterogeneity, and inform development of genetically informed interventions.}, issn = {0955-8829} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rusawdavidf_2025, title = {How does the content of the 20th I.S.P.O. World Congress align with the United Nations Sustainable Development Goals?}, author = {Rusaw, David F. and Chadwell, Alix and Hermansson, Liselotte and Houdijk, Han and Johannesson, Anton G. and Kyberd, Peter and Nilsen, Rune and Nolstedt, Pia and Plettenburg, Dick and Prinsen, Erik and Seccombe, Stephen and Zahedi, Saeed}, year = {2025}, journal = {Prosthetics and Orthotics International}, volume = {49}, number = {3}, pages = {257--259}, doi = {10.1097/PXR.0000000000000468}, url = {1967357}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, issn = {0309-3646} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lihansen_2025, title = {How Long Should We Sleep? Exploring the Relationship Between Sleep Duration and the Prevalence of Depression}, author = {Li, Hansen and Zhang, Guodong and Cao, Yang and Tian, Haodong and Liu, Haowei and Yin, Mingyue and Zhang, Xing}, year = {2025}, journal = {International Journal of Behavioral Medicine}, doi = {10.1007/s12529-025-10427-1}, url = {2023953}, language = {eng}, publisher = {Springer}, keywords = {mental; patient health questionnaire-9; public health}, abstract = {BACKGROUND: The relationship between sleep duration and depression represents a critical public health concern. This study examined how weekday and weekend sleep durations are associated with depression prevalence among US adults. The primary research question was: What is the nature of this association across weekdays and weekends?METHOD: Data were drawn from the most recent pre-pandemic cycle of the National Health and Nutrition Examination Survey (NHANES; 2017-March 2020), including 4089 adults aged 20 years and older. Correlational and non-linear regression analyses were conducted to explore the associations between sleep duration and depression indicators. Analyses were also stratified by gender to investigate potential gender differences.RESULTS: Spearman correlation and restricted cubic spline analysis indicated that weekend sleep duration was correlated with depression prevalence, but not with the total depression score or the annoyance of depression. Restricted cubic spline further analysis revealed a U-shaped association of sleep duration with the prevalence, total score, and annoyance of depression. The inflection points for depression prevalence were approximately 7.7 h for weekdays and 8.3 h for weekends. Better sleep durations were identified as 7.5-7.8 h on weekdays and 8.0-8.7 h on weekends, based on the expected odds ratios (ORs) with median sleep durations as the reference. Meanwhile, some gender differences were also observed.CONCLUSION: This study supports and extends previous findings, confirming that both insufficient and excessive sleep are associated with higher depression prevalence. Sleep duration in the identified beneficial ranges (using median sleep duration as a reference) may help reduce the risk of depression, with slight variations by gender. Our findings further underscore the complex relationship between sleep and mental health and suggest the need to attend to intra-week variations in sleep behavior. These insights may inform the development of more refined and personalized mental health promotion strategies in the future.}, issn = {1070-5503} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sundbergbodil_2025, title = {How primary school students use their disciplinary drawings to navigate between everyday and scientific discourses of water}, author = {Sundberg, Bodil and Andersson, Johanna and Areljung, Sofie and Hermansson, Carina and Skoog, Marianne}, year = {2025}, journal = {Chemistry Education Research and Practice}, volume = {26}, number = {3}, pages = {631--646}, doi = {10.1039/d4rp00080c}, url = {1943138}, language = {eng}, publisher = {Royal Society of Chemistry}, keywords = {biology education; social semiotics; species knowledge; teaching strategies; visual representations}, abstract = {In this study, we investigate how young students can make use of their own disciplinary drawings to support transitions between everyday and scientific discourses of water. The empirical data consists of video-recorded stimulated recall interviews with six student pairs (age 8 years), conducted six months after they had been introduced to a water theme that included disciplinary drawing techniques. During the interviews, we provided students with their drawings as recall material. To stimulate a stalled discussion further or to support a new line of thought, we also asked supporting questions and provided the students with plastic models of water molecules, and a bottle of water. To trace their reasoning over time during the interview, the empirical material was used to construct semantic profiles for all student pairs underpinned by Legitimation Code Theory (LCT). Our findings show that most students used their drawings to bridge everyday experiences and scientific explanations of phenomena involving water. The plastic models and the water bottle however had varying effects, sometimes leading to adding a scientific discourse, and sometimes leading to off-topic reasoning. The students generally needed adult guidance to use their own drawings for navigating between everyday and scientific reasoning. However, our findings also show that some students were able to independently use their drawings to move between everyday and scientific discourse, in a way that suggests a gradual deepening of their understanding of the chemical properties of water. Based on these findings, we advocate for emergent disciplinary drawing, in combination with guided discussions, as an age-appropriate method for supporting primary students to navigate between everyday and scientific discourses in chemistry class. This approach could ensure that the educational value of students’ creative efforts when drawing extends beyond the moment of creation, to also foster a richer language that can open for new ways of understanding and making sense of the world.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssonfredrik_2025_3, title = {How Reliable Are GPT-4o and LLAMA3.3-70B in Classifying Natural Language Requirements? The Impact of the Temperature Setting}, author = {Karlsson, Fredrik and Chatzipetrou, Panagiota and Gao, Shang and Havstorm, Tanja Elina}, year = {2025}, journal = {IEEE Software}, volume = {42}, number = {6}, pages = {97--104}, doi = {10.1109/MS.2025.3572561}, url = {1981195}, language = {eng}, publisher = {Institute of Electrical and Electronics Engineers (IEEE)}, keywords = {predictive models; accuracy; transformers; training; natural languages; temperature measurement; software reliability}, abstract = {Classifying natural language requirements (NLRs) plays a crucial role in software engineering, helping us distinguish between functional and non-functional requirements. While large language models offer automation potential, we should address concerns about their consistency, meaning their ability to produce the same results over time. In this work, we share experiences from experimenting with how well GPT-4o and LLAMA3.3-70B classify NLRs using a zero-shot learning approach. Moreover, we explore how the temperature parameter influences classification performance and consistency for these models. Our results show that large language models like GPT-4o and LLAMA3.3- 70B can support automated NLRs classification. GPT-4o performs well in identifying functional requirements, with the highest consistency occurring at a temperature setting of one. Additionally, non-functional requirements classification improves at higher temperatures, indicating a trade-off between determinism and adaptability. LLAMA3.3-70B is more consistent than GPT-4o, and its classification accuracy varies less depending on temperature adjustments.}, issn = {0740-7459} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kronqvisthrdmalin_2025, title = {How school leaders navigate neoliberal education reform : A scoping review}, author = {Kronqvist Håård, Malin}, year = {2025}, journal = {Education Policy Analysis Archives}, volume = {33}, doi = {10.14507/epaa.33.8807}, url = {2010642}, language = {eng}, publisher = {Arizona State University}, keywords = {school leader; neoliberal education reform; resistance; scoping review}, abstract = {The aim with this scoping review is to provide an overview of research on school leaders’ responses to neoliberal education reform. The review offers insights into how macro-level policies translate into micro-level experiences. By mapping existing studies on school leaders’ lived experiences under neoliberal reforms, it provides valuable knowledge for policymakers, educational leaders, and researchers seeking to navigate and influence these ongoing transformations. This article employs a resistance theory perspective. I identified 21 articles that met all the inclusion criteria through the search. I undertook both a descriptive and a content analysis. The latter considers how school leaders navigate the reforms, and how they resisted them. The results show that resistance was manifested in terms such as speaking one’s mind, irony, simulation and compliance. These studies exemplify some of the problems associated with the ‘new professionalism’ fashioned by educational policy seeking to steer the work of schools in a competitive school marketplace. Overall, the review underscores the transformative nature of neoliberal reforms on education and the imperative for using resistance and power theories to both help shed light on the sometimes soul- altering changes these initiatives can achieve and point to possible counter-discourse and counter-conduct.}, file = {https://oru.diva-portal.org/smash/get/diva2:2010642/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_garciarosanna_2025, title = {How Should We Study Heterogeneity in Entrepreneurship? Moving the Field to an Inclusive Approach}, author = {Garcia, Rosanna and Atkins, Rachel M. B. and Bonillas, Ezekiel and Brush, Candida and Gartner, William B. and Welter, Friederike and Al-Dajani, Haya and Amoros, Jose Ernesto and Berglund, Karin and de Bruin, Anne and Dey, Pascal and Dodd, Sarah and Galloway, Laura and Hechavarria, Diana M. and Jackson, Debora and Keim, Jan and Lewis, Alexander and Lindbergh, Jessica and Liu, Cathy Yang and Lubinski, Christina and Nair, Anil and Newman, Arielle and O'Toole, Jay and Price, Gregory and Radu-Lefebvre, Miruna and Ram Obe, Monder and Randolph, Angela and Ro, Eunki and Schwartz, Birgitta and Sindani, Tabitha and Villeseche, Florence and Wadhwani, R. Daniel and Wettermark, Anna and Xheneti, Mirela}, year = {2025}, journal = {Entrepreneurship: Theory & Practice}, doi = {10.1177/10422587251347048}, url = {2011749}, language = {eng}, publisher = {Sage Publications}, keywords = {optimal distinctiveness theory; inclusive entrepreneurship; marginalized entrepreneurs; heterogeneity in research; epistemological considerations}, abstract = {Entrepreneurship scholarship faces challenges related to diverse populations, striving to balance inclusivity with the recognition of unique entrepreneurial identities. Applying optimal distinctiveness theory, we explore the relationship between belongingness and uniqueness in entrepreneurship research. Catalyzed by Bakker and McMullen's 2023 article on inclusivity in entrepreneurship, we utilized natural language processing to examine responses about inclusive entrepreneurship from 29 scholars dedicated to marginalized populations. Findings suggest that employing varied research methods and integrating structural and epistemological considerations can enhance our understanding of entrepreneurial heterogeneity. We advocate for entrepreneurship research that values individual experiences while promoting inclusive practices, highlighting the need for evolving scholarly paradigms to reflect entrepreneurial differences.}, issn = {1042-2587} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sjbergcarina_2025, title = {How to Achieve Highly Professional Care in the Postoperative Ward : The Care of Infants and Toddlers}, author = {Sjöberg, Carina and Ringdal, Mona and Lundqvist, Pia and Jildenstål, Pether}, year = {2025}, journal = {Journal of Perianesthesia Nursing}, volume = {40}, number = {1}, pages = {95--99}, doi = {10.1016/j.jopan.2024.03.019}, url = {1881864}, language = {eng}, publisher = {Elsevier}, keywords = {general anesthesia; infant; postanesthesia care unit; postoperative care; toddler}, abstract = {PURPOSE: The purpose of this study was to describe the experiences of critical care nurses (CCNs) and registered nurse anesthetists (RNAs) when monitoring and observing infants and toddlers recovering from anesthesia. DESIGN: A qualitative design with a critical incident approach.METHODS: Semistructured individual interviews were conducted with a purposeful sample of CCNs and RNAs (n = 17) from postanesthesia care units at two hospitals. The critical incident technique approach was used to guide the interviews, and data were analyzed inductively using thematic analysis.FINDINGS: The main finding was the CCNs' and RNAs' description of how they "watch over the children and stay close" to provide emotional and physical safety. CCNs' and RNAs' experiences of observing and managing the children's small, immature airways were reflected in the theme "using situation awareness of the small, immature airways." The theme "understanding emergence agitation" describes the challenge that arises when children are anxious, feel insecure, and have pain, and the theme "having parents nearby" shows the necessity and value of involving parents in their children's care.CONCLUSIONS: Findings from this study suggest that caring for infants and toddlers recovering from anesthesia requires experience and both technical and nontechnical skills. These are prerequisites for achieving readiness for planning, setting priorities, and adapting one's behavior if an adverse event occurs. Alertness and the ability to solve acute problems and make quick decisions are essential because of the risks associated with children's small, immature airways, as is the ability to understand and respond to emergence agitation. Having parents nearby is equally important for creating the conditions for compassionate child- and family-centered care.}, issn = {1089-9472} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssonmartin_2025_1, title = {How You Sample Determines What You Find : Investigating Bias in Parliamentary Data Sampling Methods}, author = {Karlsson, Martin and Borgström, Eric and Lundahl, Christian}, year = {2025}, journal = {Digital Humanities in the Nordic and Baltic Countries Publications}, volume = {7}, number = {1}, pages = {79--89}, doi = {10.5617/dhnbpub.12237}, url = {1941619}, language = {eng}, publisher = {University of Oslo}, keywords = {parliamentary data; sampling error; school marketisation}, abstract = {This study addresses the issue of sampling error within research on subsets of parliamentary text corpora. Two samples of parliamentary speeches relating to the marketisation of the Swedish education system, drawn thr ough different sampling techniques, are analysed and compared. The analyses find that diverging sampling methodologies can be complementary as each method adds substantial quantities of unique documents to the dataset. Further, the diverging sampling methodologies employed produce documents with similar semantic content. However, analyses of the distributi on of speeches between party affiliations and speakers indicate va st differences between the two samples. These results indicate that sampling frames can substantially influence the findings of parliamentary text analyses. We conclude that combining different sampling techniques can be a way to reduce the ris k of sampling error, which in turn can have a strong influence on the conclusions drawn from analyses of parliamentary texts. }, file = {https://oru.diva-portal.org/smash/get/diva2:1941619/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_barkerdean_2025, title = {How young migrants perceive school health education in Sweden}, author = {Barker, Dean and Caldeborg, Annica and Quennerstedt, M. and Varea, V.}, year = {2025}, journal = {Health Education Research}, volume = {40}, number = {3}, doi = {10.1093/her/cyaf012}, url = {1954425}, language = {eng}, publisher = {Oxford University Press}, abstract = {The aim of this paper is to provide insights into how young people who have been forced to migrate perceive school health education. Eighteen individuals aged 15-19 years (10 females, 8 males, average age 16.9 years) took part in either focus group interviews (n = 7) or individual interviews (n = 1). Participants were first presented with short scenarios concerning health education and were invited to use these scenarios as starting points to discuss their own experiences of health education. Participants were then presented with a collection of photographs that portrayed people displaying broad dimensions of health. Participants were asked to discuss the significance of the health dimensions in their lives, and describe how these dimensions were covered in school health education. Our findings suggest three broad perceptions of health education content: a moderately enthusiastic perception, a disengaged perception, and a marginalized perception. These findings: raise questions about whether the provision of health education matches the needs of young migrants, point to cultural differences in the way health topics are understood, and suggest that school health education might influence how migrants interact with health service providers.}, issn = {0268-1153} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hstademma_2025, title = {HPV testing alone as a test of cure after treatment with cervical loop excision : a retrospective register-based cohort study}, author = {Håstad, Emma and Aarnio, Riina and Bergengren, Lovisa and Olovsson, Matts}, year = {2025}, journal = {Infectious Agents and Cancer}, volume = {20}, number = {1}, doi = {10.1186/s13027-025-00690-y}, url = {1992616}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {adenocarcinoma in situ; conization; follow-up studies; papillomavirus infections; retrospective studies; squamous intraepithelial lesions; uterine cervical neoplasms}, abstract = {BACKGROUND: Women treated with cervical loop electrosurgical excision procedure require follow-up to detect residual or recurrent HSIL+, defined as high-grade squamous intraepithelial lesions, adenocarcinoma in situ or cervical cancer. Currently, co-testing with cytology and human papillomavirus (HPV) analysis is usually recommended. This study investigates whether HPV testing alone is comparable to co-testing in detecting HSIL + up to three years after treatment. Recurrence rates of HSIL + are also presented, with follow-up extending up to 18 years.METHODS: This retrospective cohort study included all 3,540 women treated with a cervical excision in Uppsala County between 1 January 2005 and 31 December 2019. Women with cancer identified in the cone biopsy were excluded. The main outcome was HSIL + detected within three years of follow-up. Sensitivity, specificity and negative predictive value were calculated for the 1,938 women who had a co-testing result as part of their test of cure. Thus, the analysis for the main outcome could finally be performed on 1,938 out of the total number of 3,540 women. Additionally, long-term data on recurrence and time to HSIL+, along with a separate analysis of results prior to cervical cancer diagnosis, were collected for the whole cohort of 3,399 women.RESULTS: The sensitivity and negative predictive value for detecting HSIL + were 69% and 97% for HPV alone, and 74% and 98% for co-testing, respectively. These differences were not statistically significant. Specificity was higher for HPV alone than for co-testing. The negative predictive value of HPV testing for excluding cervical cancer (n = 5) within three years was 100%. Recurrence rate of HSIL + in the three-year follow up was 8%, and the total recurrence rate of HSIL + with a mean follow-up of nine years was 10%. Mean time to recurrence was 28 months. None of 19 cervical cancer cases identified in the long-term follow-up had a co-testing result showing negative HPV but positive cytology.CONCLUSIONS: HPV testing alone, as a single test, is comparable to co-testing in detecting HSIL + up to three years after treatment independently of margin status, and demonstrates a higher specificity. Cytology plays a very limited role in the test of cure analysis and could therefore be omitted.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_qadrisamif_2025, title = {HSD17B13 loss-of-function protects against steatosis-induced hepatic phosphatidylcholine depletion by promoting polyunsaturated fatty acid retention in humans in vivo and in experimental models}, author = {Qadri, Sami F. and Hodson, Leanne and Porthan, Kimmo and Juuti, Anne and Penttilä, Anne K. and Hyötyläinen, Tuulia and Oresic, Matej and Johnson, Elspeth and Srnic, Nikola and Boyd, Sonja and Arola, Johanna and Carleton, Michael and McReynolds, Cindy and Hsu, Heather and Yki-Järvinen, Hannele}, year = {2025}, journal = {Journal of Hepatology}, volume = {82}, number = {Suppl. 1}, url = {1973079}, language = {eng}, publisher = {Elsevier}, abstract = {Background and aims: Phosphatidylcholines (PCs) are a major hepatic reservoir of polyunsaturated fatty acids (PUFAs). In murine models of metabolic dysfunction-associated steatotic liver disease (MASLD), liver injury is induced by PUFA-PC depletion. The lipid droplet enzyme HSD17B13 metabolizes PUFA derivatives, and its loss-of-function variant rs72613567:TA protects against steatohepatitis (MASH) and fibrosis, although the mechanism underlying this protection remains unknown. We investigated whether hepatic PUFA-PC metabolism is influenced by MASLD or the protective HSD17B13 variant.Method: Obese patients with a liver biopsy (n = 135) underwent genotyping for HSD17B13 rs72613567:TA and analysis of the hepatic lipidome by UPLC-MS. A state-of-the-art deep learning image analysis method (Aiforia Technologies) quantified steatosis via the hepatic parenchymal fat fraction. Using a recruit-by-genotype approach, we studied homozygous rs72613567:TA carriers (n = 13) and non-carriers (n = 13) to determine whether the variant affects incorporation of 13C-labeled PUFAs linoleic acid (LA) and alphalinolenic acid (ALA) into triglycerides (TGs) and phospholipids (PLs) secreted by the liver in very-low-density lipoprotein (VLDL). We tested whether targeting HSD17B13 with a small molecule inhibitor, INI-822, affects PC metabolism using two models: in vitro, a primary human liver-on-a-chip system challenged with high-fat media for 20 days; and in vivo, Zucker obese rats fed either an atherogenic diet or a choline-deficient, L-amino acid-defined high-fat diet for 21 days.Results: Human MASLD livers were characterized by a marked depletion of hepatic PUFA-PCs containing 5–8 double bonds. Steatosis had a particularly accentuated effect to lower PUFA-PCs in individuals without the HSD17B13 rs72613567:TA variant. However, this effect was abolished in variant carriers due to markedly increased concentrations of hepatic PUFA-PCs compared to non-carriers. Homozygous carriers had significantly decreased incorporation of [U-13 C]LA into VLDL-TG (P < 0.001) and of [U-13 C] LA and[U-13 C]ALA into VLDL-PL (P = 0.01 and 0.05), consistent with retention of these PUFAs in the liver. In vitro, inhibition of HSD17B13 by INI-822 in the human liver-on-a-chip system lowered fibrotic markers while stabilizing choline utilization and increasing PC concentrations. In vivo, inhibition of HSD17B13 in Zucker obese rats fed MASH-inducing diets reduced liver enzymes and dose-dependently increased hepatic PC concentrations.Conclusion: In humans, HSD17B13 rs72613567:TA prevents MASLD-induced hepatic PUFA-PC depletion by retaining PUFAs within the liver. Pharmacological inhibition of HSD17B13 recapitulates the human phenotype in vitro and in vivo. These findings suggest tha thepatic PC enrichment is central to the protective effects associated with HSD17B13 loss-of-function.}, issn = {0168-8278} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_harrisondebbie_2025, title = {Human and natural actor equivalence? It depends…}, author = {Harrison, Debbie and Prenkert, Frans}, year = {2025}, url = {2038833}, language = {eng}, keywords = {actors; identity; natural actors; natural resources; sustainability}, abstract = {Recent work within industrial marketing (e.g., Helkkula & Arnould, 2022; Arnould & Helkkula, 2024) debates how awarding natural resources the status of actors enables human actors to better protect these, rather than operating with an agenda of exploitation. In IMP, we can problematise the interplay between natural resources and natural actors (Harrison & Prenkert, 2023). In other words, the dynamics between being a natural resource now and potentially an actor of the future, or resource-actor transitions. The potentiality of natural actors becoming equivalent to human actors within IMP can hence be debated. In this short paper, we propose four forms of natural actors. The four natural actor forms represent different ways in which a natural resource can change status. The four natural actor forms are (i) a natural resource is re-classified as a natural actor when it has some property rights awarded to it, (ii) a natural actor without human-awarded property rights but demonstrates self-awarded agency, (iii) a natural actor that has property rights and self-awarded agency, and (iv) when natural actors are working together with humans, such as farm animals. The paper ends with a short conclusion about the potential dynamics involved within and across the four forms of natural actor.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_boulouiscaroline_2025, title = {Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu}, author = {Boulouis, Caroline and Mouchtaridi, Elli and Müller, Thomas R. and Mak, Jeffrey Y. W. and Fairlie, David P. and Bergman, Peter and Michaëlsson, Jakob and Halfvarson, Jonas and Mjösberg, Jenny and Buggert, Marcus and Sandberg, Johan K.}, year = {2025}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, volume = {122}, number = {6}, doi = {10.1073/pnas.2414230122}, url = {1935291}, language = {eng}, publisher = {Proceedings of the National Academy of Sciences (PNAS)}, keywords = {il-10; mait cells; mr1; t cells; human}, abstract = {Mucosal-associated invariant T (MAIT) cells are unconventional T cells that mediate rapid antimicrobial immune responses to antigens derived from microbial riboflavin pathway metabolites presented by the evolutionarily conserved MR1 molecules. MAIT cells represent a large pre-expanded T cell subset in humans and are involved in both protective immunity and inflammatory immunopathology. However, what controls the functional heterogeneity of human MAIT cell responses is still largely unclear. Here, combining functional and transcriptomic analyses, we investigate how MAIT cell response programs are influenced by the cytokine milieu at the time of antigen recognition. Activation by MR1-presented antigen together with IL-12 induces intermediate levels of IFNγ and TNF, as well as a regulatory profile with substantial IL-10 production and elevated expression of TIM-3, LAG-3, and PD-1. Activation by the combination of antigen and IL-12 induces a c-MAF-dependent program required for IL-10 production. The MAIT cell-derived IL-10 mediates both autocrine and paracrine immune regulation. In contrast, coactivation of MAIT cells with IL-18 induces IL-17, GM-CSF, IFNγ, and TNF, without IL-10. Notably, IL-18 dominantly counteracts IL-10 expression. The activation states biased toward IL-10 or IL-17 production are reversible and do not represent stable subsets. Finally, MR1-restricted TCR-mediated activation without cytokine coactivation drives primarily granzyme B cytolytic arming. Altogether, these findings demonstrate that human MAIT cells adapt their functional effector response during antigen recognition to cytokine cues in the microenvironment, and identify programs biased toward either regulatory c-MAF-dependent IL-10 expression, or an inflammatory IL-17 and GM-CSF profile.}, issn = {0027-8424} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jacobssonmattias_2025, title = {Hur man kan skapa meningsfulla rutiner för en hållbar primärvård}, author = {Jacobsson, Mattias and Näsholm, Malin and Rosales, Virginia}, year = {2025}, journal = {AllmänMedicin}, volume = {46}, number = {2}, pages = {48--49}, url = {1959315}, language = {swe}, publisher = {Svensk förening för allmänmedicin - SFAM}, issn = {0281-3513} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_lindstrmanton_2025, title = {Hur ska elever lära sig att föra resonemang om samband mellan litterära verk och de historiska sammanhang de tillkommit i?}, author = {Lindström, Anton}, year = {2025}, pages = {41--42}, url = {2006416}, language = {swe}, keywords = {litteraturhistoria; läromedel; litterär kompetens; litteraturhistoriedidaktik}, abstract = {I Gy25 specificeras varken vilken litteratur som ska läsas i litteraturhistorieundervisningen, eller varför litteraturen ska läsas. Nytt är dock betoningen på elevens förmåga att föra resonemang om sambanden mellan litterära verk och de sammanhang de tillkommit i, vilket aktualiserar frågan om vad sådana resonemang egentligen innebär och vilken typ av sammanhang som avses. Läroböcker fyller en normerande funktion för litteraturundervisningen (Johansson 2022, Ullström 2009) och idag görs stora satsningar på analoga läromedel (regeringen.se, 2024-09-17). Det framstår därmed som angeläget att undersöka hur litteraturhistoriska läroböcker stimulerar eleven att föra resonemang om äldre litterära texter. I mitt pågående avhandlingsprojekt undersöker jag utifrån ett material bestående av litteraturhistoriska översiktsverk för Gy25, hur litteraturhistoria framställs, motiveras och problematiseras, samt vilka förväntningar översiktsverken har på mottagaren vad gäller läsning och bearbetning av äldre litterära texter. I projektet operationaliseras de didaktiska grundfrågorna. Vad-frågan knyts till beräkningar av läroböckernas texturval, vilket utgör en grund för den kvalitativa textanalysen. I varför-frågan inbegrips inte bara hur litteraturhistoriestudiet och texturvalet motiveras, utan också läroböckernas självreflexiva inslag kring framställningarna. Hur-frågan riktas till läroböckernas uppgifter för att synliggöra vilken litterär kompetens de stimulerar till (Torell 2002, Rosenblatt 2002, Langer 2017). Här diskuteras även hur historisk kontextualisering (Kjellgren 2022), historiserande läsningar (Skarstein 2022) och (litteratur)historisk resonemangsförmåga (Persson & Berg 2021) yttrar sig. Uppgifterna analyseras enligt modellen explore, categorise, select och interpret (Morrisson 2019). I analysen inbegrips vem-frågan, vilken knyts till lärobokens modelläsare (Eco 2008/1979).I föredraget presenteras delar av de preliminära forskningsresultaten från analysen av Punkt Litteraturhistoria. I fokus står frågan om hur det specifikt litteraturhistoriska lärandet kommer till uttryck i läroboken. Tentativa resultat visar att läroboken i hög grad präglas av samtidsorienterade och icke-historiserande frågor, vilka nyttiggör litteraturen som stimuli för reflektioner kring dagsaktuella samhällsfrågor, snarare än att träna eleverna i ett kontextuellt tänkande.    } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_plssonsara_2025, title = {Hydrophobic and Hydrophilic IOLs in Patients with Uveitis - A Randomised Clinical Trial}, author = {Pålsson, Sara and Schuborg, Claes and Sterner, Bertil and Andersson Grönlund, Marita and Zetterberg, Madeleine}, year = {2025}, journal = {Clinical Ophthalmology}, volume = {19}, pages = {373--383}, doi = {10.2147/OPTH.S493398}, url = {1936500}, language = {eng}, publisher = {Dove Medical Press}, keywords = {biocompatibility; cataract; complications; implant; inflammation}, abstract = {PURPOSE: To compare inflammatory response, visual acuity, and complications of two intraocular lenses (IOLs) in patients with and without uveitis. SETTING: Tertiary referral centre at Sahlgrenska University Hospital/Mölndal, Sweden.DESIGN: Prospective randomised controlled trial.PATIENTS AND METHODS: Patients with and without uveitis eligible for cataract surgery were randomised to receive a hydrophobic or a hydrophilic square-edged intraocular lens (IOL). Patients undergoing bilateral surgery received a hydrophobic IOL in one eye and a hydrophilic in the other. Visual acuity, flare, and central foveal thickness were used as outcome measures.RESULTS: In total, 34 (61%) patients (52 eyes) with uveitis and 22 (39%) non-uveitic patients (38 eyes) were included in the study. Comparable corrected distance visual acuity (CDVA) was seen, regardless of IOL material. Flare, six months postoperatively, for those undergoing bilateral surgery, showed no significant difference between eyes receiving a hydrophilic IOL or a hydrophobic IOL; mean difference was -3.2 (SD ± 20.7) ph/ms between eyes with uveitis (p = 0.53) and -0.6 SD ± 7.5 ph/ms between eyes without uveitis (p = 0.77). No significant difference in cystoid macular edema (CME) was seen for uveitic patients receiving a hydrophobic IOL (n = 2; 8.0%) and those receiving a hydrophilic IOL (n = 6; 22.2%; p = 0.25).CONCLUSION: No significant differences in postoperative inflammatory reaction or rate of CME were seen regardless of using a hydrophobic or a hydrophilic IOL. In general, an improvement in CDVA was seen after cataract surgery with both types of IOLs. Thus, the present study did not support either of the IOL materials as advantageous in patients with uveitis.}, issn = {1177-5467} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sofidana_2025_1, title = {Hyperreality, Polarization and Prejudice : Social Media Descriptions of Swedish Child Welfare Services}, author = {Sofi, Dana and Stier, Jonas and Wahlström, Emmie}, year = {2025}, journal = {Child & Family Social Work}, pages = {1--10}, doi = {10.1111/cfs.70075}, url = {2011903}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {disinformation; hyperreality; migrants; polarization; social media; swedish child welfare services}, abstract = {This article examines how the Swedish child welfare services (CWSs) are described in Arabic-speaking social media, with a focus on the ‘LVU campaign.’ The material consists of Facebook and YouTube posts and comments about the Swedish CWSs' actions in child mistreatment cases involving migrant families. These posts and comments were written in Arabic, had a substantial number of interactions (likes, shares etc.), were openly accessible and were published between January 2021 and December 2023. Through thematic analysis of posts and comments, four themes emerge: ‘The heartless CWS bandits,’ ‘Sweden in moral decline (the land of haram),’ ‘The infidel West at war with Islam and God’ and ‘Faithful, just and loving families.’ These themes are further examined through three conceptual dichotomies: particularism–universalism, reality–hyperreality and the construction of‘ us’–‘them.’ The analysis shows that social media accounts shape perceptions of ‘the other’ and fuel mistrust in the commentary fields of posts of ‘real’ events. The accounts illustrate the challenge of balancing universal rights with respect for cultural differences and the minority rights of migrant families. The study highlights how such dynamics can accentuate in-group preferences and fuel inter-group polarization by amplifying certain versions of reality to explain the CWSs' actions towards migrant families.}, issn = {1356-7500}, file = {https://oru.diva-portal.org/smash/get/diva2:2011903/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hellquistfelicia_2025, title = {Hypoglossal Nerve Palsy Following Cervical Spine Surgery-Two Case Reports and a Systematic Review of the Literature}, author = {Hellquist, Felicia and El-Hajj, Victor Gabriel and Buwaider, Ali and Edström, Erik and Elmi-Terander, Adrian}, year = {2025}, journal = {Brain Sciences}, volume = {15}, number = {3}, doi = {10.3390/brainsci15030256}, url = {1948519}, language = {eng}, publisher = {MDPI}, keywords = {hnp; anterior approach; cervical spine; complications; hypoglossal nerve palsy; posterior approach; spine surgery}, abstract = {BACKGROUND/OBJECTIVES: Hypoglossal nerve palsy (HNP) is a rare complication after cervical spine surgery and is reported after both anterior and posterior approaches. It often presents with dysarthria, dysphagia, and hoarseness. We present a systematic review of the literature and two cases of patients presenting with confirmed HNP after anterior cervical spine surgery.METHODS: Two retrospective case reports and a systematic review of the literature were presented. The electronic databases PubMed and Web of Science were systematically searched from inception.RESULTS: In total, 17 cases of HNP were reported in the literature, including the two hereby presented. Ten cases involved the anterior approach and seven the posterior approach. The reported risk of HNP following cervical spine surgery varied between 0.01% and 2.5% depending on the procedure. The main etiology was mechanical compression of the nerve. Most of the cases recovered within a few months with conservative treatment. In some cases, permanent hypoglossal injury with persistent symptoms was reported. In both of the current cases, the symptoms gradually improved and completely resolved after a few months.CONCLUSIONS: HNP is a rare complication after cervical spine surgery. The causes of hypoglossal palsy are multifactorial, but mechanical injury is the most common. A thorough understanding of the nerve's anatomy is essential to minimize the risk of injury during anesthesia, patient positioning, and surgery. Understanding the underlying mechanisms contributing to HNP post-cervical spine surgery enables the implementation of preventive measures to mitigate its occurrence.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_berglezpeter_2025_1, title = {Hållbarhetsmålen har alltmer urvattnats och politiserats}, author = {Berglez, Peter}, year = {2025}, journal = {Respons : recensionstidskrift för humaniora & samhällsvetenskap}, pages = {1--11}, url = {1951840}, language = {swe}, publisher = {Tidskriften Respons}, keywords = {hållbar utveckling}, abstract = {Peter Berglez undrar vad som händer med hållbarhetsmålen i det rådande politiska landskapet och argumenterar för de bakomliggande idéernas potential.}, issn = {2001-2292} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_19, title = {Högsta förvaltningsdomstolen medger avdragsrätt för ränta på förvärvslån}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031775}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 8 maj 2025 medgav Högsta förvaltningsdomstolen ränteavdrag för ett lån från ett irländskt koncernbolag för att förvärva samtliga andelar i ett externt bolag. Skuldförhållandet ansågs inte uteslutande eller så gott som uteslutande har uppkommit för att intressegemenskapen ska få en väsentlig skatteförmån. Professor Eleonor Kristoffersson analyserar domen.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_20, title = {Högsta förvaltningsdomstolen : Personlig utveckling och självledarskap omfattas inte av den reducerade skattesatsen för kultur – analys}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031832}, language = {swe}, publisher = {JP Infonet}, keywords = {mervärdesskatt; moms}, abstract = {Högsta förvaltningsdomstolen har slagit fast att föreställningarna ”Självledarskap – konsten att leda sig själv” och ”Livet ska levas och inte bara överlevas” inte omfattas av den reducerade mervärdesskattesatsen sex procent. I stället omfattas de av standarsskattesatsen 25 procent. JP Infonets expert professor Eleonor Kristoffersson analyserar avgörandet.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_isacssonalexander_2025_3, title = {I floden av källpublikationer : Mediehistoriska perspektiv på svensk urkundsutgivning, 1834–1847}, author = {Isacsson, Alexander}, year = {2025}, journal = {Historisk Tidskrift}, volume = {145}, number = {2}, pages = {216--249}, url = {1961048}, language = {swe}, publisher = {Svenska Historiska Föreningen}, issn = {0345-469X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_thunbergsara_2025_2, title = {“I Put Her in the Baby Stroller and Left” : The Escape Route From Violence to a Domestic Violence Shelter for Mothers and Children}, author = {Thunberg, Sara and Arnell, Linda}, year = {2025}, journal = {Violence against Women}, volume = {31}, number = {9}, pages = {2288--2307}, doi = {10.1177/10778012241251971}, url = {1855633}, language = {eng}, publisher = {Sage Publications}, keywords = {children; domestic violence shelter; escape; intimate partner violence; leaving process}, abstract = {Little is known about mothers’ and children's escape from violence and its aftermath when living in secure accommodation, especially with regard to children. The aim is to investigate mothers’ experiences of their escape, and their considerations regarding the well-being of their young children before or during their escape, based on 14 interviews. Using a narrative thematic analysis, the results show that the escape was often planned, but that the planning horizon varies. In many cases, the mothers’ social network served as a stepping-stone during the escape, before they continued by moving to a domestic violence shelter (DVS). Implications for policy and practice are offered.}, issn = {1077-8012}, file = {https://oru.diva-portal.org/smash/get/diva2:1855633/FULLTEXT01.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_barkerruchtinatalie_2025_1, title = {I wanted to make a complaint, but no one told me what I had signed up to do : Navigating the abuse complaint reporting process}, author = {Barker-Ruchti, Natalie and Purdy, Laura G.}, year = {2025}, pages = {119--139}, doi = {10.1108/S1476-285420250000025007}, url = {1935809}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {abuse and maltreatment; complaint reporting process; narrative; the ‘pixie’ ideal; women’s artistic gymnastics}, abstract = {Gymnasts worldwide have turned to media to speak out about their experiences of abuse in sport. More formally, services to report abuse have been recognised as important; however, we know little about athletes' experiences of the process. Therefore, we consider in this chapter how (former) athletes experience the process of reporting abuse and maltreatment. This chapter begins with a narrative poem that was created using direct quotes from an interview with a former gymnast, Lisa (pseudonym), who described her involvement with her national gymnastics federation's reporting process. We then examine reporting services and discuss the reasons why (former) athletes may not report abuse and maltreatment. As a conceptual framework, we present the pixie model of women's artistic gymnastics (WAG) as the root of the culture of fear, control and silence that prevents gymnasts from reporting their experiences, and discuss factors that enable the reporting of abuse and maltreatment. To illustrate the ways the WAG pixie model shaped Lisa's reporting experience, the poem presented at the outset of this chapter is extended to a narrative about her engagement with reporting processes. The chapter concludes with a call to put abuse and maltreatment on the sports governance agenda, the development of trauma-informed processes and further research on reporting abuse in sport.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_vanbellejono_2025_1, title = {"I wouldn’t want to live there!" Imagining the Nordics through Ingmar Bergman’s films}, author = {Van Belle, Jono}, year = {2025}, pages = {176--186}, doi = {10.1002/9781119886709.ch11}, url = {1924982}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_turpinwilliams_2025, title = {IBD Prediction Is Possible, but How Far Are We from Implementing It?}, author = {Turpin, Williams and Kalili, Hamed and Halfvarson, Jonas and Croitoru, Kenneth}, year = {2025}, journal = {Inflammatory Bowel Diseases}, volume = {31}, number = {Supplement_2}, pages = {S41--S50}, doi = {10.1093/ibd/izaf197}, url = {2006248}, language = {eng}, publisher = {Oxford University Press}, keywords = {crohn’s disease; metabolomic; microbiome; predictive model; proteomics}, abstract = {Crohn's disease and ulcerative colitis, collectively known as inflammatory bowel diseases (IBDs), are chronic gastrointestinal diseases with poorly characterized pathophysiology. Recent advancements in the identification of preclinical biomarkers of IBD have shed some insight into our ability to predict or prevent these conditions. This review discusses the growing body of research on biomarkers ranging from genetics, measures of gut permeability, and microbiome signatures to circulating proteomics and metabolomics. In addition, the review will highlight the potential application of these biomarkers for early detection and risk stratification of IBD. Notably, proteomic markers such as CXCL9 and MMP-10, along with metabolic perturbations detectable prior to clinical diagnosis, provide promising avenues for understanding IBD pathogenesis and guiding prevention strategies. Furthermore, the development of integrative risk scores, combining multiomic data with demographic and lifestyle factors, could offer a personalized approach to disease prediction and prevention. While these advances present significant opportunities, challenges remain in data complexity and variability of biomarkers. This review emphasizes the importance of continued longitudinal studies and clinical trials to validate predictive models. Ultimately, the integration of early risk prediction holds the potential to reduce IBD incidence through targeted, proactive strategies.}, issn = {1078-0998} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_jonssonjessica_2025_3, title = {ICC Trust Fund: for Victims : but how?}, author = {Jonsson, Jessica}, year = {2025}, url = {1998584}, language = {eng}, abstract = {The International Criminal Court (ICC) has been a cornerstone of international justice since its establishment in 2002, with the Rome Statute providing a framework for prosecuting genocide, war crimes, and crimes against humanity. A crucial aspect of the ICC's mandate is providing reparations and support to victims of these atrocities, primarily through the ICC Victims Trust Fund. However, the effectiveness of this mechanism depends heavily on the participation, support, and legislative frameworks of ICC member states. This article provides an overview of the current state of research on ICC member states' engagement with the ICC Victims Trust Fund, examining the legislative and policy frameworks that facilitate or hinder support for victims. By synthesizing existing literature, this article aims to identify best practices, challenges, and areas for improvement in member states' participation and support for the ICC Victims Trust Fund, ultimately contributing to a more robust and victim-centered international justice system.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jiyuyan_2025, title = {Identification of Novel Iodinated Polyfluoroalkyl Ether Acids and Other Emerging PFAS in Soils Using a Nontargeted Molecular Network Approach}, author = {Ji, Yuyan and Pan, Yitao and Miao, Xinchen and Wang, Congcong and Sheng, Nan and Su, Zhaoben and Yeung, Leo W. Y. and Dai, Jiayin}, year = {2025}, journal = {Environmental Science and Technology}, volume = {59}, number = {1}, pages = {869--879}, doi = {10.1021/acs.est.4c11961}, url = {1927517}, language = {eng}, publisher = {American Chemical Society (ACS)}, keywords = {environmental transformation; iodinated polyfluoroalkyl ester sulfonic acids; molecular network; nontarget analysis; per- and polyfluoroalkyl substances}, abstract = {Despite advancements in high-resolution screening techniques, the identification of novel perfluoroalkyl and polyfluoroalkyl substances (PFAS) remains challenging without prior structural information. In view of this, we proposed and implemented a new data-driven algorithm to calculate spectral similarity among PFAS, facilitating the generation of molecular networks to screen for unknown compounds. Using this approach, 81 PFAS across 12 distinct classes were identified in soil samples collected near an industrial park in Shandong Province, China, including the first reported occurrence of 12 iodine-substituted PFAS. Among them, the standards of four iodine-substituted polyfluorinated ether sulfonates (I-PFESA) were successfully synthesized, enabling structural confirmation and subsequent quantitative analysis. Although the median concentration of ∑I-PFESA (0.74 ng/g dw) in soil samples was lower than that of ∑H-PFESA (hydrogen-substituted, 61.96 ng/g dw) and ∑Cl-PFESA (chlorine-substituted, 2.98 ng/g dw), embryotoxicity assays in zebrafish revealed that 6:2 I-PFESA exhibited greater toxicity compared to 6:2 Cl-PFESA of the same chain length. This highlights the need for a closer examination of the toxic effects of I-PFESA. Notably, the proposed algorithm, based on novel PFAS spectral similarity, provides new perspectives on the environmental behavior and transformation of I-PFESA, although further investigation is required to elucidate the underlying mechanisms of their toxicity.}, issn = {0013-936X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tranphamtuehung_2025, title = {Identification of TRIM21 and TRIM14 as Antiviral Factors Against Langat and Zika Viruses}, author = {Tran, Pham-Tue-Hung and Kabir, Mir Himayet and Asghar, Naveed and Hathaway, Matthew R. and Hayderi, Assim and Karlsson, Roger and Karlsson, Anders and Taylor, Travis and Melik, Wessam and Johansson, Magnus}, year = {2025}, journal = {Viruses}, volume = {17}, number = {5}, doi = {10.3390/v17050644}, url = {1965485}, language = {eng}, publisher = {MDPI}, keywords = {flavivirus; antiviral host factor; trim14; trim21; trim38; zikv; lgtv; wnv; ns3; ns5}, abstract = {Flaviviruses are usually transmitted to humans via mosquito or tick bites, whose infections may lead to severe diseases and fatality. During intracellular infection, they remodel the endoplasmic reticulum (ER) membrane to generate compartments scaffolding the replication complex (RC) where replication of the viral genome takes place. In this study, we purified the ER membrane fraction of virus infected cells to identify the proteins that were enriched during flavivirus infection. We found that tripartite motif-containing proteins (TRIMs) including TRIM38, TRIM21, and TRIM14 were significantly enriched during infection with mosquito-borne (West Nile virus strain Kunjin and Zika virus (ZIKV)) and tick-borne (Langat virus (LGTV)) flaviviruses. Further characterizations showed that TRIM21 and TRIM14 act as restriction factors against ZIKV and LGTV, while TRIM38 hinders ZIKV infection. These TRIMs worked as interferon-stimulated genes to mediate IFN-I response against LGTV and ZIKV infections. Restriction of ZIKV by TRIM14 and TRIM38 coincides with their colocalization with ZIKV NS3. TRIM14-mediated LGTV restriction coincides with its colocalization with LGTV NS3 and NS5 proteins. However, TRIM21 did not colocalize with ZIKV and LGTV NS3 or NS5 protein suggesting its antiviral activity is not dependent on direct targeting the viral enzyme. Finally, we demonstrated that overexpression of TRIM21 and TRIM14 restricted LGTV replication.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_peterssonjoakim_2025, title = {Identifying and assessing risks for intimate partner violence : Social workers’ experiences in rural and remote areas}, author = {Petersson, Joakim and Larsson, Anna-Karin}, year = {2025}, journal = {Nordic Journal of Criminology}, volume = {26}, number = {2}, pages = {1--17}, doi = {10.18261/njc.26.2.1}, url = {1935025}, language = {eng}, publisher = {Universitetsforlaget}, keywords = {intimate partner violence; risk identification; risk assessment; social workers; rural; remote}, abstract = {This study aimed to explore social workers’ shared experiences and perceptions of identifying intimate partner violence (IPV) and assessing the risk for re-victimization of such violence in a Swedish rural and remote context. Thirteen focus group interviews were conducted with social workers (N = 38) from 17 rural and remote municipalities and analyzed using thematic analysis. Three themes were identified: Challenges with identifying IPV, Varying risk assessment expertise, and Lack of practical utility of available risk assessment tools. Identifying IPV was challenging for many reasons, primarily due to a lack of routines and knowledge of IPV. These challenges were also perceived to extend to the assessment of risk for re-victimization. For example, the required knowledge of risk assessment practices was scarce, unevenly distributed, and difficult to maintain as IPV cases were rarely identified. The results are generally in line with previous studies. However, given that this study was conducted with professionals working in rural and remote areas, we also identified challenges unique to a sparsely populated context that are discussed.}, issn = {2578-983X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_deutschmannmats_2025_2, title = {Identifying and Defining Language Support Needs in Second Language of Instruction Examination Contexts}, author = {Deutschmann, Mats and Zelime, Justin}, year = {2025}, journal = {NORRAG special issue}, volume = {11}, pages = {85--88}, url = {1998150}, language = {eng}, publisher = {Geneva Graduate Institute}, keywords = {multilingual education; assessment; language support; high-stakes exams; language policy}, abstract = {The Seychelles’ education system does not provide for language support during exams, disadvantaging students with limited English proficiency. We argue that more inclusive language-in-assessment policies are needed to ensure that high-stakes exams assess subject knowledge rather than language proficiency. Suggested improvements include the implementation of language accessibility principles, multilingual options, and marking practices that focus on knowledge rather than language.}, issn = {2571-8010}, file = {https://oru.diva-portal.org/smash/get/diva2:1998150/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_bojanamii_2025_1, title = {Identifying Lipidomic Signatures and Microbial Metabolites in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease from Serbia : A Metabolomics-Based Approach to Liver Dysfunction}, author = {Bojana, Mićić and Ignjatović, Sofija and Gašić, Uroš and Božić-Antić, Ivana and Bjekić-Macut, Jelica and Barbosa, Joao and Nguyen, Anh Hoang and Duberg, Daniel and Castro Alves, Victor and Orešič, Matej and Hyötyläinen, Tuulia and Djordjevic, Ana and Milutinović, Danijela Vojnović and Veličković, Nataša}, year = {2025}, pages = {275--275}, url = {2030707}, language = {eng}, publisher = {Metabolomcis Society}, keywords = {metabolic dysfunction-associated steatotic liver disease (masld); liver dysfunction; lipidomics; metabolomics; biomarker discovery}, abstract = {Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease in the Western world, and is rapidly increasing worldwide. Serbia, along with other Balkan countries, faces particularly high rates of MASLD, yet remaining underrepresented in large-scale European research initiatives, including the MASLD registry. The absence of structured clinical and molecular datasets from this region emphasize the need for locally conducted, population-specific studies. This work presents preliminary results from the first comprehensive multi-omics study of MASLD in the population from Serbia, aiming to identify a lipidomic signature of liver dysfunction and to explore microbial metabolites potentially involved in disease pathophysiology, using both untargeted and targeted metabolomics approaches. Plasma and fecal samples were collected from 122 participants, including MASLD patients and sex-, age-, and BMI-matched healthy controls. Lipids from plasma, as well as semi-polar and polar metabolites, were extracted using a monophasic extraction solution (MeOH:MTBE:IPA (20:15:15)) containing internal standards. The samples were analyzed using ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS, Agilent Technologies, Santa Clara, CA, USA). The analysis was performed on an ACQUITY UPLC BEH C18 column (2.1 mm × 100 mm, particle size 1.7 µm; Waters, Milford, USA). Data were processed and analyzed using MZmine 3 software, with lipid and metabolite identification based on an in-house library. A total of 1751 lipids and 1315 semi-polar/polar metabolites were detected in plasma samples, with 214 lipids and 132 semi-polar/polar metabolites identified. Principal component analysis did not reveal significant separation between MASLD patients and healthy controls. At the lipid class level, however, distinct clustering patterns emerged, pinpointing alterations in lipid metabolism. Ongoing analyses aim to further refine these observations and investigate associations with clinical parameters, with the goal of uncovering meaningful patterns that could contribute to the discovery of disease biomarkers and the elucidation of pathophysiological mechanisms.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssonsune_2025, title = {Identifying Useful Indicators for Nowcasting GDP in Sweden}, author = {Karlsson, Sune and Mazur, Stepan and Raftab, Mariya}, year = {2025}, url = {1938734}, language = {eng}, publisher = {Örebro University School of Business}, keywords = {nowcasting; swedish gdp; midas; mixed-frequency var}, abstract = {This paper focuses on identifying useful indicators for nowcasting GDP in Sweden. We analyze 35 monthly indicators spanning the period from 1993 to 2023. Additionally, we evaluate the group-wise performance of these indicators. The analysis is conducted using mixed-data sampling (MIDAS) and mixed-frequency VAR models in both individual and pooled setups forn owcasting. While the primary focus is on nowcasting, we also assess the performance of the indicators for backcasting and forecasting. For nowcasting, we identify 16 indicators in the individual setup and 23 indicators in the pooled setup that outperform the benchmark. Group-wise, indicators belonging to the survey, interest & exchange rates, and public finance groups exhibit strong performance in the individual setup. Notably, in the pooled setup, the output, survey, price, interest & exchange rates, and public finance groups demonstrate strong performance.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_allardkarin_2025, title = {Identity formation in bimodal-bilingual children of Deaf adults (Codas)}, author = {Allard, Karin and Roos, Carin}, year = {2025}, journal = {The Journal of Deaf Studies and Deaf Education}, volume = {30}, number = {4}, pages = {481--495}, doi = {10.1093/jdsade/enaf040}, url = {1977666}, language = {eng}, publisher = {Oxford University Press}, abstract = {This study concerns adult Codas, or hearing children of deaf1, signing parents. They are of significant interest to language researchers as bimodal bilinguals who grew up in a multifaceted bicultural environment. The study is based on interviews with 12 Coda adults in Sweden (aged 18–50 years). The interviews were translated, transcribed, and coded for thematic analysis. The analysis draws on the theoretical concepts of social identity and investment proposed by Norton (Norton Peirce, B. (1995). Social identity, investment, and language learning. TESOL Quarterly, 1(29), 9–31 https://faculty.educ.ubc.ca/norton/Norton%201995%20p.pdf.). The main findings indicate that for these Codas, the everyday experience of bimodal bilingualism acts as a driving force in the formation of social identities, fostering linguistic, cultural, and social awareness, which, in turn, influences how individuals invest in their languages and cultures.}, issn = {1081-4159}, file = {https://oru.diva-portal.org/smash/get/diva2:1977666/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vazquezdelmercadomonica_2025, title = {IFN-γ+874 T/A Is Associated with High Levels of Sera CPK in Patients with Inflammatory Myopathies}, author = {Vazquez-Del Mercado, Monica and Martin-Marquez, Beatriz Teresita and Martinez-Garcia, Erika Aurora and Petri, Marcelo Heron}, year = {2025}, journal = {Current Issues in Molecular Biology}, volume = {47}, number = {7}, doi = {10.3390/cimb47070492}, url = {1989214}, language = {eng}, publisher = {MDPI}, keywords = {dermatomyositis; polymyositis; idiopathic inflammatory myopathies; polymorphism}, abstract = {Aim of the study: Idiopathic inflammatory myopathies (IIM) are autoimmune diseases with a low prevalence and incidence worldwide. The levels of IFN-gamma production by T-lymphocytes are related to disease activity. IFN-gamma +874 T/A (rs2430561) has been shown to alter the serum levels of IFN-gamma in different pathologies. The aim of this work is to explore the role of IFN-gamma +874 T/A polymorphism in IIM.Methods: Using a specific sequence primer-polymerase chain reaction (SSP-PCR), the genotype was defined for normal healthy controls (HC) and patients with IIM. Markers of muscle damage, clinical features and treatment were collected from chart at the time of diagnosis and at recruitment point. All the data were analyzed by demographic characteristics, genotype, type of IIM, treatment, clinical features, and enzymatic levels.Results: No association was found comparing the genotypes or alleles of the IIM patients vs. HC. On the other hand, the TT genotype, previously described as a high producer of INF gamma, showed higher levels of CPK at diagnosis in IIM patients, whereas females at diagnosis and males in remission presented higher levels.Conclusions: Even with a limited number of patients due to the rarity of this disease, no association was found between the disease development. Further, the TT genotype promoted muscle damage due to CPK elevation in the sera compared to the TA/AA genotype in patients with IIM. This could be genetic evidence of the impact of IFN-gamma in the disease activity of IIM patients. A larger cohort is needed to confirm these results.}, issn = {1467-3037} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rehnbergjohanna_2025, title = {IgA Nephropathy and the Risk of Primary Infections : A Swedish Population-Based Cohort Study}, author = {Rehnberg, Johanna and Ludvigsson, Jonas F. and Emilsson, Louise}, year = {2025}, journal = {American Journal of Nephrology}, volume = {56}, number = {4}, pages = {445--456}, doi = {10.1159/000544753}, url = {1948849}, language = {eng}, publisher = {S. Karger}, keywords = {cohort study; iga nephropathy; infections; sepsis}, abstract = {INTRODUCTION: IgA nephropathy is the most common primary kidney disease in the world and has a highly variable clinical presentation. While studies have indicated a link between glomerular disease and infections, large-scale studies on IgA nephropathy are missing.METHODS: In our study, IgA nephropathy was defined as having a kidney biopsy record 1997-2011 in Sweden. Each IgA nephropathy patient was matched with five reference individuals based on age, sex, calendar year, and county of residence. We excluded individuals with earlier organ transplants, HIV, immunodeficiency, or end-stage kidney disease. Linear and Cox regressions, adjusted for age, sex, education, and diabetes, were performed to analyze total infections and antimicrobial treatments in both patients and reference individuals. Sibling analyses were also performed.RESULTS: The linear regression analysis revealed a significant association between IgA nephropathy and the overall frequency of infections compared to the general population (β = 0.44; 95% CI: 0.35-0.53) and siblings (β = 0.36; 95% CI: 0.23-0.49). Similarly, antimicrobial prescriptions, especially antibiotics, were more common in IgA nephropathy compared to the general population and to siblings. Cox regression showed an elevated risk of any infection (adjusted hazard ratio [aHR] = 2.00; 95% CI: 1.84-2.18) and sepsis (aHR = 3.18; 95% CI: 2.17-4.65) corresponding to one extra case of sepsis per 63 patients followed for 10 years. The strongest associations were seen for urinary tract infections; ear, nose, and throat infections; and musculoskeletal and gastrointestinal infections.CONCLUSION: Conclusively, our study demonstrates an increased prevalence of infections and antibiotic prescriptions in IgA nephropathy patients. The increased risk of sepsis warrants clinical awareness and prevention.}, issn = {0250-8095} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_rehnbergjohanna_2025_1, title = {IgA Nephropathy : Comorbidities and Prognosis - Registry-based Studies}, author = {Rehnberg, Johanna}, year = {2025}, url = {1952594}, language = {eng}, publisher = {Örebro University}, keywords = {iga nephropathy; comorbidities}, abstract = {This thesis investigates the associations between IgA nephropathy (IgAN), a common form of primary glomerulonephritis, and several health outcomes including inflammatory bowel disease (IBD), cancer, infections, and the reliability of biopsy data from the Swedish Renal Registry (SRR).In a population-based cohort study of 3,963 IgAN patients and 19,978 controls, IgAN was linked to a significantly higher risk of both future and preceding IBD diagnoses. IBD also increased the risk of developing end-stage renal disease (ESRD) in IgAN patients, underscoring the importance of monitoring gastrointestinal comorbidities in this population.Another cohort study of 3,882 IgAN patients examined the association between IgAN and cancer. An elevated cancer risk was identified, but only in patients who progressed to ESRD, suggesting that the increased cancer incidence is related to advanced kidney disease rather than IgAN itself.A third study explored the frequency of infections in IgAN patients, revealing a higher incidence of infections and increased antimicrobial use compared to both the general population and sibling controls. The study highlighted a marked risk of sepsis, emphasizing the need for proactive infection prevention in IgAN management.Finally, validation of biopsy data from the SRR demonstrated a high positive predictive value (95%) for IgAN diagnosis. This reinforces the reliability of the SRR as a valuable tool for future research on IgAN.Together, these findings contribute to a deeper understanding of IgAN’s broader clinical implications, and the potential risks associated with its progression.}, file = {https://oru.diva-portal.org/smash/get/diva2:1952594/FULLTEXT01.pdf;https://oru.diva-portal.org/smash/get/diva2:1952594/FULLTEXT04.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_crucianic_2025, title = {IgG AND IgA ANTI-LIN28A AUTOANTIBODIES ARE ASSOCIATED WITH HISTOLOGICAL ACTIVITY ANDTREATMENT RESPONSE LUPUS NEPHRITIS}, author = {Cruciani, C. and Gatto, M. and Nikopoulos, D. and Lindblom, J. and Lagutkin, D. and Beretta, L. and Iagnocco, A. and Franco, C. and Fedrigo, M. and Idborg, H. and Peyper, J. and Barturen, G. and Doria, A. and Sherina, N. and Tamirou, F. and Alarcon-Riquelme, M. and Houssiau, F. and Parodis, Ioannis}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {84}, number = {Suppl. 1}, pages = {948--949}, doi = {10.1136/annrheumdis-2025-eular.A894}, url = {1986034}, language = {eng}, publisher = {Elsevier}, keywords = {autoantibodies; renal system; real-world evidence; biomarkers}, abstract = {Background: Currently known autoantibodies in Systemic Lupus Erythematosus (SLE) either lack specificity or present low sensitivity (e.g., anti-dsDNA and anti-Sm autoantibodies). At the same time, the antigen specificity for several autoantibodies that are present in SLE patients has yet to be determined. In a study involving patients with different autoimmune diseases and healthy controls, IgG and IgA anti-LIN28A antibodies were identified and validated as autoantibodies with a high specificity and sensitivity for SLE.Objectives: To assess the presence, prevalence, and clinical correlates of IgG and IgA anti-LIN28A in active lupus nephritis (LN).Methods: Adult patients with a biopsy-proven LN were enrolled between 2017 and 2023 from Cliniques universitaires San-Luc in Brussels, Belgium, and Padua University Hospital in Padua, Italy. Patients were regularly followed up; clinical and laboratory features were collected in a longitudinal fashion. A diagnostic kidney biopsy was performed at baseline. A subgroup of patients underwent a per-protocol repeat kidney biopsy at 12 months together with a second blood withdrawal. Patients' serum samples were analysed using KREX technology-based microarrays (i-Ome Discovery; Sengenics) and screened for circulating IgG and IgA autoantibodies against 1609 proteins. Log2-transformed mean net signal intensities of IgG and IgA anti-LIN28A were median-normalised and batch-corrected together with measurements from 39 serum samples from healthy controls (HC) from the PRECISESADS clinical consortium. A positivity cut-off for IgG and IgA anti-LIN28A was defined as median plus two interquartile ranges (IQRs) of the distribution levels of the antibodies in HC. Associations between anti-LIN28A levels and clinical and histological features were assessed at different time points. Data were analysed and compared using one-way ANOVA and t-test for continuous normally-distributed variables or chi-squared and Mann-Whitney U tests for non-parametric variables. Spearman's rank correlation (r) was used to assess correlations between non-normally distributed variables.Results: Thirty-six patients with active, biopsy-proven, LN were enrolled (Table 1). At baseline, levels of IgG and IgA anti-LIN28A were significantly elevated in LN patients compared to HC (p<0.0005). Among LN patients, 87.0% and 77.8% were positive for IgG and IgA anti-LIN28A, respectively. Patients negative for the IgG isotype had significantly lower NIH Activity Index (AI) scores at the diagnostic kidney biopsy (p<0.005). There was a correlation between IgG anti-LIN28A levels and total NIH AI scores (r=0.47, p=0.011), mainly driven by endocapillary proliferation (r=0.46, p0.0219) and tubulointerstitial mononuclear cell infiltration (r=0.45, p=0.022) (Figure 1). Patients displaying cellular crescents at the diagnostic biopsy showed significantly higher levels of IgG (p=0.0145) and IgA (p=0.04) anti-LIN28A. After 12 months of treatment, autoantibody levels were significantly reduced (p<0.001 for both isotypes). Among 18 patients who underwent a per-protocol repeat kidney biopsy, 2 patients with persistent histological inflammation (NIH AI scores >0) displayed a milder decrease in IgG anti-LIN28A levels (p<0.05). Moreover, patients showing EULAR renal response (proteinuria <0.5 g/day and stable/improved eGFR) showed a tendency towards a more prominent decline in IgG anti-LIN28A compared to that seen in non-responders, but this difference did not reach statistical significance (p=0.07). No correlation was seen between changes in IgA anti-LIN28A levels and histological or clinical response to treatment for LN.Conclusion: IgG and IgA anti-LIN28A antibodies are markedly elevated in active LN patients. IgG anti-LIN28A showed a significant association with inflammation at the histological level, especially with endocapillary proliferation and tubulointerstitial inflammatory infiltrates. Moreover, patients achieving histological remission in per-protocol repeat kidney biopsy (NIH AI=0) displayed a more prominent decrease in IgG anti-LIN28A levels compared with LN patients with persistent histological inflammation in the repeat biopsy (NIH AI>0). Our data point to a potential role for IgG anti-LIN28A antibodies as diagnostic and prognostic markers of LN.}, issn = {0003-4967} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisi_2025, title = {IGG AND IGA AUTOANTIBODIES AGAINST NOVEL ANTIGEN SPECIFICITIES IN SYSTEMIC LUPUS ERYTHEMATOSUS WITH DIFFERENTIAL UNDERLYING MECHANISMS HERALDING PROMISE FOR EARLY DIAGNOSIS}, author = {Parodis, I. and Nikolopoulos, D. and Lindblom, J. and Beretta, L. and Cetrez, N. and Peyper, J. and Barturen, G. and Jakobsson, P. J. and Alarcon-Riquelme, M. and Idborg, H.}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {83}, number = {Suppl. 1}, doi = {10.1136/annrheumdis-2024-eular.6003}, url = {1953973}, language = {eng}, publisher = {Elsevier}, keywords = {autoantibodies; '-omics; biomarkers}, abstract = {Background: Systemic lupus erythematosus (SLE) is characterised by the production of a multitude of autoantibodies (Abs), yet the antigen specificities remain elusive for most of these Abs. The diagnosis of SLE is supported by the presence of certain Abs; however, SLE-specific Abs currently used for diagnosis or surveillance, e.g., anti-dsDNA and anti-Smith, lack sensitivity.Objectives: To perform a broad explorative screen of IgG and IgA antibodies against autoantigen specificities in patients with SLE vs healthy controls (HC) to gain insight into disease pathogenesis and identify novel Abs that could potentially serve as diagnostic biomarkers.Methods: We analysed plasma samples from 289 patients with SLE and 196 age- and sex-matched HC from the European PRECISESADS project (NTC02890121). Samples were screened for IgG and IgA seroreactivity against a panel of >1,600 protein autoantigens using KREX-based i-Ome arrays (Sengenics). Differential expression analysis was performed with the limma R package adjusting for e.g., polyspecific antibody reactivity. The level of significance for differentially expressed Abs (DEAbs) was set at p<0.05 and |fold change (FC)| >1.5. Machine learning (ML) was applied to identify the ten most discriminative Abs. ROC analysis was carried out for each individual DEAb and for the combined top ten ML-selected DEAb model, producing discriminative performance metrics including sensitivity, specificity, area under the curve (AUC), and accuracy. Functional analysis was performed with gene ontology (GO) enrichment and signalling pathway impact analysis using the corresponding antigens of the DEAbs (p<0.1; |FC| >1.1).Results: DEAb analysis revealed 14 IgG and 2 IgA upregulated DEAbs in patients with SLE vs HC. Of IgG DEAbs, anti-LIN28A (sen=0.77, spe=0.69, AUC=0.80), anti-HBGB2 (sen=0.65, spe=0.81, AUC=0.79), anti-HMG20B (sen=0.75, spe=0.71, AUC=0.70), and anti-NRF1 (sen=0.63, spe=0.80, AUC=0.77) demonstrated the best discriminative capacity. ML identified the top ten IgG Abs distinguishing SLE from HC (SSB, TROVE2, LIN28A, TFCP2, HNRNPA2B1, KLF12, RAD51, CCNB1, EEF1D, PSMD4) with a good whole-panel performance (sen=0.84, spe=0.72, AUC=0.78). Functional analysis of IgG DEAbs revealed 2 GO-term enrichments at the cellular component level: extracellular region and cell surface, suggesting that autoantigens eliciting IgG in SLE are accessible at the cell surface or released by cell lysis and may be altered in an immunogenic manner by SLE-associated pathophysiological processes. Of IgA DEAbs, anti-LIN28A (sen=0.65, spe=0.83, AUC=0.80) and anti-SSB (sen=0.64, spe=0.82, AUC=0.78) demonstrated the best discriminative capacity. ML identified the top ten IgA Abs discriminating SLE from HC (APOBEC3G, SUB1, LIN28A, SSB, TROVE2, PCBP2, TFCP2, PRKRA, ZMAT3, UBE2I) with reasonable whole-panel performance (sen=0.84, spe=0.69, AUC=0.76). Functional analysis of IgA DEAbs revealed 17 GO-term enrichments related to DNA-binding transcription repressor activity, chromatin binding, transcription factor binding, and regulation of transcription by RNA polymerase II, suggesting that autoantigens eliciting IgA in SLE are enriched for nucleic acid binding.Conclusion: This study corroborated both classical IgG Ab specificities (e.g., anti-SSB, anti-TROVE2) and previously reported specificities (anti-LIN28A, anti-HBGB2, anti-HMG20B, anti-HNRNPA2B1)1 and identified novel IgG (anti-NRF1, anti-PCBP2, anti-TGIF2, HMGN5, anti-SUB1, anti-PSIP1, anti-CCNB1) and novel IgA (anti-LIN28A) Abs described for the first time in SLE, with robust accuracy in distinguishing SLE from HC. Importantly, these novel Abs outperformed the accuracy of currently used Abs, e.g., anti-dsDNA (sen=0.36, spe=0.95, AUC=0.61)1. ML further enhanced the diagnostic accuracy, heralding promise for the early diagnosis of SLE. Functional analysis revealed distinct mechanisms with suggested differential roles in the production of IgG and IgA Abs in SLE.}, issn = {0003-4967} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindkvistmadelene_2025, title = {IL1RAP Expression in Human Atherosclerosis : A Target of Novel Antibodies to Reduce Vascular Inflammation and Adhesion}, author = {Lindkvist, Madelene and Göthlin Eremo, Anna and Paramel Varghese, Geena and Anisul Haque, Sheikh and Rydberg Millrud, Camilla and Rattik, Sara and Grönberg, Caitríona and Liberg, David and Sirsjö, Allan and Fransén, Karin}, year = {2025}, journal = {Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease}, volume = {14}, number = {10}, doi = {10.1161/JAHA.124.039557}, url = {1958679}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {huvecs; il‐1; il‐33; il‐36; endothelial cells}, abstract = {BACKGROUND: Blockade of IL1RAP (interleukin 1 receptor associated protein) was recently shown to reduce atherosclerosis in mice, but the effect on human vascular cells is largely unknown. Targeting the IL1RAP coreceptor represents a novel strategy to block the IL1RAP-dependent cytokines IL (interleukin)-1, IL-33, and IL-36. In the present study, we aimed to evaluate the role of novel antibodies targeting IL1RAP to reduce the effects of IL-1β, IL-33, or IL-36γ in human vascular cells.METHODS: Expression of IL1RAP was observed in human atherosclerotic plaques by immunohistochemistry and microarray and in endothelial cells by flow cytometry. Endothelial cells were cultured with IL-1β, IL-33, or IL-36γ cytokines with or without IL1RAP antibodies and analyzed with Olink proteomics, ELISA, Western blot, and real-time quantitative polymerase chain reaction. The functional effect of IL1RAP antibodies on endothelial cells were analyzed with adhesion and permeability assays.RESULTS: Olink proteomics showed inhibition of the inflammatory proteins LIF (leukemia inhibitory factor), OPG (osteoprotegerin), CCL4 (C-C motif chemokine ligand 4), and MCP-3 (monocyte chemoattractant protein 3) by IL1RAP-blockade in endothelial cells after IL-1β stimulation. In addition, the IL1RAP antibodies inhibited IL-1β, and IL-33 induced IL-6 and IL-8 secretion. Secretion of MCP-1 (monocyte chemoattractant protein 1) was induced by IL-1β, IL-33, and IL-36γ, and subsequently was inhibited by IL1RAP antibodies. Similar effects were found on mRNA expression level. Endothelial expression of the adhesion markers ICAM1, VCAM1, and SELE were significantly reduced by IL1RAP antibodies, and neutrophil adhesion to endothelial cells induced by IL-1β and IL-33 was reduced by IL1RAP blockade. In human atherosclerotic lesions, IL1RAP expression correlated with markers of inflammation like IL6, IL8, and MCP1.CONCLUSIONS: IL1RAP-targeting antibodies can reduce the expression of inflammatory cytokines and markers of adhesion in endothelial cells, which may be of importance for future putative targeted treatments against cardiovascular disease.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kalaycyksekfatma_2025, title = {IL-1β alters the virulence of uropathogenic Escherichia coli}, author = {Kalaycı-Yüksek, Fatma and Wu, Rongrong and Rangel, Ignacio and Demirel, Isak}, year = {2025}, journal = {Scientific Reports}, volume = {15}, number = {1}, doi = {10.1038/s41598-025-26055-4}, url = {2010446}, language = {eng}, publisher = {Nature Publishing Group}, keywords = {c. elegans; colonization; cross-kingdom interaction; il-1β; uropathogenic e. coli}, abstract = {Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infection (UTI). While the role of UPEC in triggering host immune responses is well studied, less is known about how host-derived cytokines influence UPEC virulence. The aim of this study was to investigate how the pro-inflammatory cytokine IL-1β affects UPEC virulence, metabolism, and host-pathogen interactions. Using the CFT073 strain, we found that IL-1β exposure induced a rapid metabolic shift characterized by decreased oxygen consumption rate (OCR) and increased extracellular acidification rate (ECAR), indicating a transition from respiration to fermentative metabolism. Microarray analysis confirmed the upregulation of fermentative (hyc) and antioxidant (katG, ahpF, grxA) genes, along with increased purine biosynthesis, supporting a metabolic state favouring stress resistance and proliferation. IL-1β also increased fimH and papC gene expression, leading to increased adhesion and invasion of bladder epithelial cells. Furthermore, IL-1β-stimulated CFT073 suppressed the gene expression of several innate immune related genes in a C. elegans infection model. Taken together, our findings suggest that IL-1β induces a virulence-enhancing metabolic change in UPEC, which could enhance its persistence and colonization of the urinary tract. This cross-kingdom signaling may have implications for infection dynamics during a UTI.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_cewepaulina_2025_1, title = {Image quality assessment in spine surgery : a comparison of intraoperative CBCT and postoperative MDCT}, author = {Cewe, Paulina and Skorpil, Mikael and Fletcher-Sandersjöö, Alexander and El-Hajj, Victor Gabriel and Grane, Per and Fagerlund, Michael and Kaijser, Magnus and Elmi-Terander, Adrian and Edström, Erik}, year = {2025}, journal = {Acta Neurochirurgica}, volume = {167}, number = {1}, doi = {10.1007/s00701-025-06503-w}, url = {1948857}, language = {eng}, publisher = {Springer}, keywords = {cone beam computed tomography; image quality; neuroradiology; neurosurgery; spine}, abstract = {OBJECTIVE: To evaluate if intraoperative cone-beam CT (CBCT) provides equivalent image quality to postoperative multidetector CT (MDCT) in spine surgery, potentially eliminating unnecessary imaging and cumulative radiation exposure.METHODS: Twenty-seven patients (16 men, 11 women; median age 39 years) treated with spinal fixation surgery were evaluated using intraoperative CBCT and postoperative MDCT. The images were independently evaluated by four neuroradiologists, utilizing a five-step Likert scale and visual grading characteristics (VGC) analysis. The area under the VGC curve (AUCVGC) quantified preferences between modalities. Intra- and inter-observer variability was evaluated using intraclass correlation coefficients (ICC). Image quality was objectively evaluated by contrast and signal-to-noise measurements (CNR, SNR).RESULTS: In image quality, CBCT was the preferred modality in thoracolumbar spine (AUCVGC = 0.58, p < 0.001). Conversely, MDCT was preferred in cervical spine (AUCVGC = 0.38, p < 0.004). The agreement was good for inter-observer and moderate in intra-observer (ICC 0.76-0.77 vs 0.60-0.71), p < 0.001. SNR and CNR were comparable in thoracolumbar imaging, while MDCT provided superior and more consistent image quality in the cervical spine, p < 0.001.CONCLUSION: In spine surgery, CBCT provides superior image quality for thoracolumbar imaging, while MDCT performs better for cervical imaging. Intraoperative CBCT could potentially replace postoperative MDCT in thoracolumbar spine procedures, while postoperative MDCT remains essential for cervical spine assessment.KEY POINTS: Subjective assessment demonstrated that CBCT was the preferred modality for thoracolumbar spine imaging, while MDCT was favored for cervical spine imaging. Agreement between readers was good, while individual readings showed moderate consistency in repeated assessments. Objective assessment of image clarity and detail showed both modalities performed equally well in the thoracolumbar spine, while MDCT performed better in the cervical spine. Intraoperative CBCT proves superior to postoperative MDCT for thoracolumbar spine imaging, potentially eliminating redundant scans, and improving workflow. Postoperative MDCT remains essential for cervical spine procedures.}, issn = {0001-6268} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wilnerzonthrnrosemarie_2025, title = {Immediate Mobilisation After Elective Colorectal Surgery-Patients' and Healthcare Professionals' Experiences : A Qualitative Study}, author = {Wilnerzon Thörn, Rose-Marie and Forsberg, Anette and Ahlstrand, Rebecca and Anderzen-Carlsson, Agneta}, year = {2025}, journal = {Scandinavian Journal of Caring Sciences}, volume = {39}, number = {3}, doi = {10.1111/scs.70072}, url = {1981273}, language = {eng}, publisher = {Blackwell Publishing}, keywords = {colorectal surgery; enhanced recovery after surgery; immediate mobilisation; postoperative care; qualitative study}, abstract = {BACKGROUND: Early mobilisation is advocated after colorectal surgery. Mobilising patients 30 min after arrival to the post-anaesthesia care unit has been shown to be feasible; however, before implementation in clinical care, the experiences of patients and healthcare professionals must be investigated. Thus, this study aims to explore patients' and healthcare professionals' experiences of immediate mobilisation.METHODS: A total of 41 patients from the intervention group of a randomised control trial investigating the effects of immediate mobilisation were included and interviewed individually between October 2017 and June 2019. Five healthcare professionals working with the intervention were also interviewed individually during fall 2018 to spring 2019. The data analyses of the two samples were conducted separately, using inductive qualitative content analysis.RESULTS: Three themes were identified from the patients' interviews: 'The body cannot keep up', describing challenges, such as burdensome symptoms, reluctance and fear that mobilisation could be harmful; 'Being in good hands', referring to receiving individual support from healthcare professionals when being mobilised and thus feeling safe; and 'A first step towards recovery', describing patients' readiness for immediate mobilisation with fewer postoperative symptoms, while recognising the benefits and feeling satisfied. An overarching theme was identified from the healthcare professionals' interviews - 'Balancing gains and challenges', which describes likely benefits to patients but also notes that mobilisation immediately after surgery is resource intensive. The professionals described their initial concerns about patients' wellbeing and safety and the adapted facilities needed for immediate mobilisation to be smooth.CONCLUSION: Immediate mobilisation after elective colorectal surgery was found to be both beneficial and challenging by patients and healthcare professionals; it requires skilled staff, sufficient resources, adapted facilities, and clear mobilisation procedures and efforts tailored to the patients' individual abilities.}, issn = {0283-9318} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_engrenjimmy_2025_1, title = {Immigrants into Loyal Citizens : The Work to Americanize the Scandinavian Immigrant Working Class in Two Harbors, Minnesota, 1915–1919}, author = {Engren, Jimmy}, year = {2025}, journal = {Swedish-American Studies}, volume = {76}, number = {1}, pages = {58--84}, doi = {10.1353/swe.2025.a975746}, url = {2019296}, language = {eng}, publisher = {University of Minnesota Press}, keywords = {swedish american; americanisation; world war 1; migration; labor studies}, abstract = {The aim of this article is to explore the dynamics of and connection between local Americanization work and antisocialist campaigning during the period before and during the First World War through the example of Two Harbors, Minnesota, a town with a significant Swedish population. The work of Americanization and the molding of loyal citizens in Minnesota was spearheaded by the Minnesota Commission of Public Safety (MCPS), which primarily targeted the immigrant working class, including the large migrant groups of Swedes, Finns, and Norwegians. The MCPS cooperated with a wide range of local constituencies in Two Harbors but the Duluth & Iron Range Railroad, a US Steel subsidiary, proved a formidable partner for the MCPS as it offered a platform for information campaigns, loyalty parades, patriotic meetings, and a range of other activities to instill loyalty in the immigrant workers. Local preachers supported the company campaign and local newspapers willingly spread the propaganda material from the MCPS. The use of the workplace and familiar local institutions is highly significant in understanding the process of top-down Americanization of immigrant workers and its success during the period around the First World War. This was a process that took place on terms decided by the local business community and its class allies in the MCPS.}, issn = {2997-4038} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_andrndaniela_2025_4, title = {Immigration, Partnership Dynamics and Welfare Persistence}, author = {Andrén, Daniela and Andrén, Thomas and Kahanec, Martin}, year = {2025}, url = {2003690}, language = {eng}, publisher = {Örebro University, School of Business}, keywords = {welfare persistence; social assistance; structural state dependence; unobserved heterogeneity; dynamic discrete choice model; ghk simulator}, abstract = {When economic crises destabilize labor markets, they offer unique opportunities to explore welfare dynamics and the interplay between partnership formation and social assistance. Using data from Sweden’s 1990s economic crisis, characterized by high unemployment, expanding budget deficit, and a large inflow of war refugees from the former Yugoslavia, we examine state dependence in social assistance, which refers to the increased likelihood that households will receive benefits in the future if they have previously received them. Because Swedish social assistance eligibility depends on household-level resources and that partnership formation may correlate with unobserved factors, we focus on individuals who were single in 1990, prior to the recession, tracking their social assistance receipt and household composition over the subsequent decade. This approach allows us to compare individuals who remain single throughout the decade with those who form partnerships, assessing how gender, country of birth, and partnership choices affect state dependence in social assistance. Using a dynamic discrete choice model that addresses both unobserved heterogeneity and initial conditions, we found differences in structural state dependence both between and within the samples of Swedish-born (SB) and foreign-born (FB) individuals. Among singles, SB women exhibit lower structural state dependence than SB men, whereas FB women display slightly higher structural state dependence than FB men but lower than SB men. For FB individuals, the structural state dependence decreases when they partner with a SB individual but increases when they partner with another FB individual, suggesting that partnering with an SB individual may reduce the structural impact of prior welfare dependency, while partnering with an FB individual may reinforce it.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_kttstrmmagdalena_2025, title = {Immune response to pneumococcal vaccination in chronic lymphocytic leukemia}, author = {Kättström, Magdalena}, year = {2025}, url = {1940288}, language = {eng}, publisher = {Örebro University}, keywords = {chronic lymphocytic leukemia; secondary immunodefi-ciency; vaccine response; pneumococcal polysaccharide vaccine; pneumococcal conjugate vaccine; pneumococcal revaccination}, abstract = {Patients with chronic lymphocytic leukemia (CLL) are at increased risk of Streptococcus pneumoniae infections due to disease- and treatment-related immune dysfunction. Vaccine responses are often impaired. This thesis evaluates the immune response to primary immunization with pneumococcal conjugate vaccine (PCV) versus pneumococcal polysaccharide vaccine (PPSV), long-term antibody persistence and the effect of revaccination in CLL patients.Study I was a randomized trial in treatment-naïve CLL patients comparing PCV and PPSV, demonstrating that PCV elicits an enhanced immune response.Study II was a prospective study evaluating B-cell subsets and plasmablast dynamics before and after revaccination. It showed that repeated revaccinations with PCV in CLL patients improves early humoral response.Study III assessed antibody persistence 5 years after primary immunization and response to revaccination, showing that CLL patients have poor long-term antibody persistence, but that revaccination with PCV enhances immunity.Study IV examined the impact of two analytical methods, multiplex immunoassay (MIA) and enzyme immunoassay (EIA), on serotypespecific IgG measurements and demonstrated their influence on vac-cine response interpretation in CLL patients. The findings in this thesis emphasize the importance of pneumococcal conjugate vaccines in CLL patients and suggest a need for revaccination to maintain protection against severe pneumococcal disease.}, file = {https://oru.diva-portal.org/smash/get/diva2:1940288/FULLTEXT01.pdf;https://oru.diva-portal.org/smash/get/diva2:1940288/FULLTEXT04.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_langeniclas_2025, title = {Immunoglobulin-G dynamics and relation to antibiotic prescriptions in MS-patients treated with rituximab : a real-world cohort}, author = {Lange, Niclas and Svenningsson, Anders and Tina, Elisabet and Hultgren, Olof and Gunnarsson, Martin}, year = {2025}, journal = {Multiple Sclerosis Journal}, volume = {31}, number = {Suppl. 3}, pages = {1186--1186}, url = {2038175}, language = {eng}, publisher = {Sage Publications}, abstract = {Introduction: Rituximab, a B-cell-depleting therapy, is widely used for multiple sclerosis (MS). While effective, long-term treatment may reduce immunoglobulin G (IgG) levels, potentially increasing infection risk.Objectives/Aims: This study evaluates IgG dynamics and antibiotic use in MS patients receiving Rituximab in Örebro County, Sweden.Methods: A retrospective cohort study was conducted on MS patients treated with Rituximab over a 10-year period. Patients included had at least two infusions and a follow-up of ⩾6 months after the last infusion. IgG levels and antibiotic prescriptions were registered longitudinally.Results: A total of 213 patients (72% female, mean age 40.1 ± 10.6 years) were included, with a mean follow-up time of 44.8 ± 10.6 months. The mean IgG level at treatment initiation was 11.5 ± 2.4 g/L, declining to 10.4 ± 2.3 g/L after the last infusion, with a mean decrease of 1.1 ± 1.4 g/L. Hypogammaglobulinemia (IgG < 6.7 g/L) occurred in 4% of patients. Serum IgG levels demonstrated a significant decline over the course of Rituximab treatment (p < 0.001). However, linear mixed modeling did not detect a statistically significant acceleration over time.Antibiotic prescriptions were recorded in 63% of patients, with a mean of 2.5 ± 3.3 prescriptions per patient. The most common indications were urinary tract infections (29%) and respiratory tract infections (19%). No significant correlation was found between lower IgG levels and higher antibiotic use.Conclusion: Rituximab treatment in MS was associated with a significant decline in IgG levels over time. However, the incidence of infections requiring antibiotics did not correlate with IgG decline, suggesting that most patients maintain sufficient immune function. These findings support the continued use of Rituximab in MS while highlighting the need for monitoring IgG levels during long-term treatment.}, issn = {1352-4585} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mattssonstig_2025, title = {Impact of carbohydrate timing on glucose metabolism and substrate oxidation following high-intensity evening aerobic exercise in athletes : a randomized controlled study}, author = {Mattsson, Stig and Edin, Fredrik and Trinh, Jonny and Adolfsson, Peter and Jendle, Johan and Pettersson, Stefan}, year = {2025}, journal = {Journal of the International Society of Sports Nutrition}, volume = {22}, number = {1}, doi = {10.1080/15502783.2025.2494839}, url = {1954442}, language = {eng}, publisher = {Taylor & Francis}, keywords = {carbohydrate metabolism; continuous glucose monitoring; exercise; fat metabolism; glucose tolerance test; nutrition}, abstract = {OBJECTIVE: The study aimed to investigate the impact of nutrient timing in relation to evening exercise. Specifically, it examined the effects of pre- or post-exercise carbohydrate (CHO) ingestion on glucose metabolism, glucose regulation, and overall substrate oxidation in well-trained athletes during and after physical exercise (PE), spanning the nocturnal period and the subsequent morning.METHODS: Ten male endurance cyclists participated in the study. The initial assessments included body composition measurements and an incremental cycle test to determine maximal oxygen uptake (V˙O2 max) and maximum power output (Wmax). Following this, participants underwent a control (rest previous day) oral glucose tolerance test (OGTT) and a familiarization exercise trial that had two objectives: (1) to establish the appropriate amount of CHO to use in the pre- or post-exercise drink during the experimental trials, and (2) to familiarize participants with the equipment and study protocol. In the three days prior to both the control and experimental trials, participants followed a standardized, individualized diet designed to meet their energy needs. During the experimental trials, participants completed two separate evening exercise sessions (50 min@70%Wmax +  ~24 min time-trial (TT)) with either pre- or post-exercise CHO ingestion (253 ± 52 g), matching the CHO oxidized during exercise. The CHO drink and a volume-matched placebo (PLA) drink (containing no energy) were randomly assigned to be consumed two hours before and directly after the experimental exercise sessions. Post-exercise nocturnal interstitial glucose levels (24:00-06:00) were continuously monitored, and a 120-min OGTT was conducted the following morning to assess substrate oxidation rates and glucose control.RESULTS: Pre-exercise CHO intake significantly lowered capillary glucose levels during steady-state exercise (mean difference 0.41 ± 0.27 mmol/L, p = 0.001) without affecting perceived exertion and TT-performance. No difference was observed in nocturnal glucose regulation (00:00-06:00) regardless of whether CHO was consumed before or after exercise. Post-exercise CHO ingestion reduced glucose tolerance during the OGTT compared to the iso-caloric pre-exercise CHO intake (mean difference 0.76 ± 0.21 mmol/L, p = 0.017). However, a post-exercise CHO intake improved respiratory exchange ratio/metabolic flexibility (MetF) significantly. Enhanced MetF during the first OGTT hour after post-exercise CHO ingestion resulted in 70% and 91% higher CHO oxidation compared to pre-exercise CHO and control, respectively (p ≤ 0.029). Average 120-min OGTT fat oxidation rates were higher with both pre- and post-exercise CHO ingestion compared to control (p ≤ 0.008), with no difference between pre- and post-exercise CHO intake.CONCLUSION: Morning glucose tolerance was markedly reduced in healthy athletes when CHO was ingested after evening exercise. However, the observed improvements in MetF during the OGTT compared to placebo post-exercise suggest a potential for enhanced athletic performance in subsequent exercise sessions. This opens exciting possibilities for future research to explore whether enhanced MetF induced by CHO-timing can translate to improved athletic performance, offering new avenues for optimizing training and performance.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_schreiberkaren_2025, title = {Impact of conflicting information on the use of antirheumatic drugs in pregnancy and breastfeeding : perspectives of healthcare providers from the global PRAISE survey}, author = {Schreiber, Karen and Graversgaard, Christine and Parodis, Ioannis and Agmon-Levin, Nancy and Aguilera, Silvia and Antovic, Aleksandra and Bertsias, George K. and Bini, Ilaria and Bobirca, Anca and Capela, Susana and Cervera, Ricard and Costedoat-Chalumeau, Nathalie and Dolhain, Radboud and Etomi, Oseme and Flint, Julia and Fonseca, Joao Eurico and Fritsch-Stork, Ruth and Förger, Frauke and Giles, Ian and Goulden, Bethan and Skorpen, Carina Götestam and Gunnarsson, Iva and Gupta, Latika and Koksvik, Hege Svean and Linde, Louise and Lykke, Jacob and Meissner, Yvette and Molto, Anna and Moore, Louise and Mosca, Marta and Nelson-Piercy, Catherine and Perez-Garcia, Luis Fernando and Raio, Luigi and Rom, Ane Lilleoere and Rottenstreich, Amihai and Saleh, Muna and Sciascia, Savino and Strangfeld, Anja and Svenungsson, Elisabet and Tektonidou, Maria G. and Tincani, Angela and Troldborg, Anne and Vojinovic, Jelena and Voss, Anne and Wallenius, Marianne and Zuniga-Serrano, Nuria and Andreoli, Laura}, year = {2025}, journal = {Therapeutic Advances in Musculoskeletal Disease}, volume = {17}, doi = {10.1177/1759720X251350087}, url = {1988287}, language = {eng}, publisher = {Sage Publications}, keywords = {antirheumatic medications; breastfeeding; lactation; patient information leaflet; pregnancy; summary of product characteristics}, abstract = {Background: Treating rheumatic musculoskeletal diseases (RMDs) during pregnancy and breastfeeding presents significant complexities, mainly due to inconsistencies between the clinical guidance documents and the reference safety information, including the summary of product characteristics (SmPC) and the patient information leaflets (PIL).Objectives: To assess healthcare professionals' (HCPs) prescribing behaviors, comfort levels, and challenges when advising patients, focusing on discrepancies between clinical guidance documents and SmPC/PIL.Design: Online survey entitled PRAISE (Perception of healthcare providers Regarding Antirheumatics in pregnancy and breastfeeding: advice, Information and patient perSpEctives) and disseminated through HCPs groups and social media.Methods: A cross-sectional survey was conducted among 414 HCPs globally. Respondents were divided into prescribers (n = 336) and non-prescribers (n = 78) based on their self-reported role in prescribing antirheumatic medications to pregnant or breastfeeding patients with RMDs. The survey covered demographics, clinical experience, confidence in prescribing, use of clinical guidelines, and experiences managing conflicting information between guidelines and SmPC/PIL.Results: Prescribers were more likely than non-prescribers to feel comfortable discussing medication safety during pregnancy. Most prescribers found clinical guidance documents useful, with 48% rating them as "very useful" and 38% as "extremely useful." In case of conflicting information between clinical guidance documents and SmPC/PIL, 58% of HCPs reported that it caused confusion and tension in patient-doctor relationships, and almost 20% of them are "likely" or "very likely" to discontinue ongoing treatment. Clear communication and shared decision-making were the most common strategies used to address patient concerns.Conclusion: HCPs often face significant challenges when advising patients with RMDs on the use of medications during pregnancy and breastfeeding. Conflicting information between clinical guidance documents and SmPC/PIL can disrupt patient-doctor relationship and lead to treatment discontinuation, with potential consequences on maternal disease control. Improved alignment between clinical guidance documents and the SmPC/PIL could enhance patient care and prevent confusion among HCPs and patients.}, issn = {1759-7218} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zhouxiaowen_2025, title = {Impact of COVID-19 pandemic on cognitive decline in community-dwelling older adults in Shanghai : a longitudinal study from 2010 to 2024}, author = {Zhou, Xiaowen and Deng, Hanzhi and Shao, Hanyu and Yang, Tao and Chen, Yuntao and Cao, Yang and Zhao, Qianhua and Ding, Ding}, year = {2025}, journal = {The Lancet Regional Health: Western Pacific}, volume = {63}, doi = {10.1016/j.lanwpc.2025.101697}, url = {2006247}, language = {eng}, publisher = {Elsevier}, keywords = {brain structure changes; covid-19 pandemic; chinese population; cognitive decline; community-based}, abstract = {BACKGROUND: In 2022, the rapid spread of the highly transmissible Omicron variant precipitated a dramatic surge in infections and a subsequent societal shutdown in Shanghai. It offers the opportunity to examine the impact of COVID-19 pandemic on cognitive decline among community-dwelling older adults.METHODS: The Shanghai Aging Study enrolled 3792 community residents aged ≥ 50 from 2010 to 2012 in central Shanghai. Demographics, medical history, ApoE genotyping, and plasma phosphorylated tau 217 (p-tau217), phosphorylated tau 181 (p-tau181), and neurofilament light chain (NfL) were collected at baseline. Cognitive function assessment and MRI scans were conducted at baseline and follow-up visits from 2014 to 2024. Study periods were defined as Wave 1 (Jan.2010-Dec.2012, baseline, pre-pandemic), Wave 2 (Jan.2014-Mar.2022, pre-pandemic), and Wave 3 (Jun.2022-Dec.2024, post-pandemic). Event study, difference-in-differences (DID), and linear mixed-effects models were employed to evaluate the pandemic's impact on cognitive trajectories and brain structural changes.FINDINGS: We observed steeper age-related declines of the Mini-Mental State Examination (MMSE) during Wave 3. The event study model adjusting for age, sex, and education, showed significant MMSE decline in Wave 3, but not in Wave 2. Declines were more pronounced in individuals with high baseline plasma p-tau217, p-tau181, and NfL, ApoE-ε4 carriers, those with multi-comorbidities, or long-term medication use. The DID and linear mixed-effects models with individual-specific follow-up data revealed accelerated declines in global cognition, executive and language function, and structural brain atrophy from Wave 2-3, compared with Wave 1-2.INTERPRETATION: The COVID-19 pandemic significantly accelerated cognitive and brain structural changes in community-dwelling older adults, particularly among those with pre-existing AD pathology or health vulnerabilities. These findings provide evidence of COVID-19 pandemic-related cognitive decline and highlight the need for mechanistic research into how direct and indirect stressors converge to drive cognitive impairment.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_uttermaria_2025, title = {Impact of emergency computed tomography on treatment and time to treatment for renal colic}, author = {Utter, Maria and Altmark, Fredrik and Popiolek, Marcin and Forsvall, Andreas and Lundström, Karl-Johan and Thiel, Tomas and Wagenius, Magnus}, year = {2025}, journal = {Scandinavian journal of urology}, volume = {60}, pages = {29--35}, doi = {10.2340/sju.v60.42593}, url = {1935298}, language = {eng}, publisher = {Taylor & Francis}, keywords = {urolithiasis; acute renal colic; emergency medicine; computed tomography; urs; eswl; pcnlintroduction}, abstract = {OBJECTIVE: The aim of this study was to evaluate the utilization and impact of emergency computed tomography (CT) on the management of renal colic, focusing on treatment decisions, time to treatment and the subsequent need for additional emergency department (ED) visits.MATERIALS AND METHODS: Retrospective analysis of patient visits to the ED in Helsingborg with a diagnosis of urolithiasis (ICD codes N20-23) between July 1, 2019 and June 30, 2020. Results: Out of 64,263 visits, 1.4% (880) visits were related to urolithiasis, involving 612 patients. Emergency CT (within 24 h) was performed in 43% of the cases, with an additional 9% undergoing CT at a subsequent emergency visit. Radiological confirmation of kidney or ureteral stone was found in 324 patients, of which 63% (204) required no treatment. Comparison between patients who underwent emergency CT and those who did not, revealed a significantly shorter time to treatment and closure in the emergency CT group. The median time to treatment was 28 days for those with an emergency CT and 59 days for those without (P < 0.001), acute surgery excluded. The median time to closure was 31 days for emergency CT compared to 37 days without emergency CT (P < 0.010), acute surgery excluded.CONCLUSION: In this study, the use of emergency CT shortened the time to treatment and rendered the patient stone free earlier compared to deferred diagnostics, with a note of caution that emergency CT may have led to increased surgical treatments for stones that might otherwise have passed spontaneously.CLINICALTRIALS: gov Identifier: NCT06535711.}, issn = {2168-1805} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jaenssonmaria_2025_1, title = {Impact of health literacy and general self-efficacy on surgical outcomes 2 years after bariatric surgery}, author = {Jaensson, Maria and Dahlberg, Karuna and Cao, Yang and Thorell, Anders and Österberg, Johanna and Nilsson, Ulrica and Stenberg, Erik}, year = {2025}, journal = {Clinical Obesity}, volume = {15}, number = {4}, doi = {10.1111/cob.70009}, url = {1943745}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {bariatric surgery; health literacy; self‐efficacy}, abstract = {After bariatric surgery, adherence to lifestyle recommendations is crucial. Health literacy and self-efficacy may impact recovery after surgery. In this multicentre study performed in three hospitals in Sweden, we evaluated any relation between preoperative health literacy and general self-efficacy on the one side and weight loss, health-related quality of life, length of stay, and complications up to 2 years after bariatric surgery on the other. Of 686 included patients, 56% (n = 382) had limited functional health literacy, 42% (n = 278) had limited communicative and critical health literacy, and 40% (n = 266) reported low general self-efficacy. Preoperative functional, communicative and critical health literacy, and general self-efficacy were not associated with the degree of weight loss at 1 or 2 years after surgery. However, limited health literacy and low general self-efficacy scores were associated with both reduced quality of life and obesity-related problems postoperatively. Further, a higher proportion of those with inadequate health literacy had a prolonged length of stay. Although patients with limited health literacy and self-efficacy may experience similar maximum weight loss after bariatric surgery as other patients, they still might have reduced health-related quality of life in terms of obesity-related problems. Increased awareness of this association as well as patient-centered support before and after bariatric surgery may be of benefit.}, issn = {1758-8103} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_katawazaiasmatullah_2025_2, title = {Impact of minimal incision repair of Rectus Abdominis Diastasis (MIRRAD) on quality of life and stress incontinence : a prospective study}, author = {Katawazai, Asmatullah and Wallin, Göran and Sandblom, Gabriel}, year = {2025}, journal = {British Journal of Surgery}, volume = {112}, number = {Suppl. 11}, pages = {xi31--xi31}, doi = {10.1093/bjs/znaf149.112}, url = {1992641}, language = {eng}, publisher = {Oxford University Press}, abstract = {Introduction: Rectus Abdominis Diastasis (RAD) is a common condition where separation of the rectus abdominis muscles results in a widening of the linea alba. This separation is often due to increased intra-abdominal pressure most notably during pregnancy. This study evaluates the impact of the minimal incision repair of rectus abdominis diastasis (MIRRAD) procedure on physical activity, muscle strength, quality of life, and overall satisfaction in women with postpartum rectus abdominis diastasis (PP-RAD).Method: A cohort of 31 female patients, aged 20-50 years, diagnosed with PP-RAD unresponsive to conservative treatment, underwent the MIRRAD procedure. Assessments were conducted preoperatively and one year postoperatively, these included the Modified Abdominal Trunk Function Protocol (MATFP), Disability Rating Index (DRI), and Urinary Disability Index (UDI) questionnaires. Physical activity intensity was monitored using accelerometers.Result: Significant improvements were observed in vigorous physical activities (Z = -2.352, p = .019), vector magnitude counts per minute (Z = -2.163, p = .031), and steps per minute (Z = -3.131, p = .002). DRI showed significant improvements in physical tasks like dressing, walking, and strenuous work (Z ranging from -2.705 to -4.603, p < .001). UDI indicated significant improvements in urinary symptoms, including reduced frequency (Z = -2.984, p = .003) and less urinary leakage (Z = -2.357, p = .018). MATFP demonstrated gains in back and abdominal muscle strength (Z = -4.321, p < .001) and trunk stability (Z = -3.991, p < .001).Discussion: The MIRRAD procedure significantly improves physical strength, trunk stability, and urinary function, enhancing daily activities and overall physical health in women with PP-RAD. Further research is recommended to evaluate long-term outcomes.}, issn = {0007-1323} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nordenskjldannam_2025_1, title = {Impact of persistence to secondary preventive medication on prognosis for patients with myocardial infarction with and without obstructive coronary arteries}, author = {Nordenskjöld, Anna M. and Lindhagen, Lars and Wettermark, Björn and Lindahl, Bertil}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {5}, doi = {10.1371/journal.pone.0324533}, url = {1968180}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {BACKGROUND: Poor adherence to secondary preventive medication after myocardial infarction (MI) negatively affects long-term prognosis, but knowledge is lacking regarding the impact of poor adherence on prognosis for patients with myocardial infarction with non-obstructive coronary arteries (MINOCA). We therefore investigated the effect of persistence to secondary preventive medication on prognosis in patients with MINOCA compared with patients with myocardial infarction with obstructive coronary arteries (MI-CAD).METHODS: In this nationwide observational study of 116,143 patients with MI recorded in the SWEDEHEART registry between 2006─2017, MINOCA were identified in 9,124 patients and MI-CAD in 107,019 patients. Persistence to treatment with aspirin, statins, beta blockers and angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin-receptor blockers (ARBs) was investigated for 5 years post discharge and patients were followed for a composite endpoint of major adverse cardiovascular events (MACE), including all-cause death, MI, ischemic stroke and heart failure.RESULTS: Persistent use of secondary preventive medications was associated with a decrease in the risk of MACE during follow-up in both MINOCA and MI-CAD patients; aspirin HR 0.70 (CI 0.60-0.82) vs. HR 0.60 (CI 0.57-0.64), statins HR 0.80 (CI 0.68-0.95) vs. HR 0.66 (CI 0.63-0.69), beta blockers HR 0.77 (CI 0.65-0.92) vs. HR 0.76 (CI 0.73-0.80) and ACEIs/ARBs HR 0.62 (CI 0.50-0.77) vs. 0.67 (CI 0.63-0.71).CONCLUSION: Persistence to secondary preventive medications after MI is associated with a reduction in the risk for MACE in both patients with MINOCA and MI-CAD. Continuous efforts to improve adherence to evidence-based medications in general to all patients with MI should be a priority.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_altaisaif_2025, title = {Impact of surgical technique on gastroesophageal reflux disease after laparoscopic sleeve gastrectomy : a nationwide observational study}, author = {Al-Tai, Saif and Axer, Stephan and Szabo, Eva and Ottosson, Johan and Stenberg, Erik}, year = {2025}, journal = {Surgery for Obesity and Related Diseases}, volume = {21}, number = {4}, pages = {465--470}, doi = {10.1016/j.soard.2024.10.033}, url = {1919303}, language = {eng}, publisher = {Elsevier}, keywords = {bougie size; distance from the pylorus; gerd; ppi; proton pump inhibitor; sleeve gastrectomy}, abstract = {BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has gained increasing popularity worldwide, yet concerns persist regarding the development of gastroesophageal reflux disease (GERD) postoperatively.OBJECTIVES: This study aimed to evaluate the influence of technical aspects of LSG, specifically bougie size and distance from the pylorus to resection line edge, on the risk of developing symptomatic GERD within 2years following surgery.SETTING: Data from the Scandinavian Obesity Surgery Registry (SOReg) and the National Prescribed Drug Register were utilized for this analysis.METHODS: A retrospective observational study was conducted encompassing all LSG patients in Sweden between 2012 and 2020 who did not receive preoperative proton pump inhibitor (PPI) prescriptions. Patients were categorized based on bougie size and pyloric distance. Regular PPI use, defined as a dispensed prescription of more than 300 tablets per year, was employed as a proxy measure of symptomatic GERD and was compared between the groups.RESULTS: The study included 7,435 patients with complete data on dispensed PPI prescription both preoperatively and throughout the 2-year follow-up period. Information on bougie size and pyloric distance was available for 97.4% and 84.9%, respectively. Narrower bougie size and greater pyloric distance were associated with increased risk of regular PPI use postsurgery. Advanced age and female sex were independent risk factors for post-LSG regular PPI use, while initial body mass index (BMI), total weight loss (%TWL), and comorbidities showed no significant associations.CONCLUSIONS: Using a narrow bougie and initiating resection at a greater distance from the pylorus were associated with higher risk of symptomatic de novo GERD following LSG.}, issn = {1550-7289} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zitvogellaurence_2025, title = {Impact of the ONCOBIOME network in cancer microbiome research}, author = {Zitvogel, Laurence and Derosa, Lisa and Routy, Bertrand and Loibl, Sibylle and Heinzerling, Lucie and de Vries, I. Jolanda M. and Engstrand, Lars and Segata, Nicola and Kroemer, Guido}, year = {2025}, journal = {Nature Medicine}, volume = {31}, number = {4}, pages = {1085--1098}, doi = {10.1038/s41591-025-03608-8}, url = {1993406}, language = {eng}, publisher = {Nature Publishing Group}, abstract = {The European Union-sponsored ONCOBIOME network has spurred an international effort to identify and validate relevant gut microbiota-related biomarkers in oncology, generating a unique and publicly available microbiome resource. ONCOBIOME explores the effects of the microbiota on gut permeability and metabolism as well as on antimicrobial and antitumor immune responses. Methods for the diagnosis of gut dysbiosis have been developed based on oncomicrobiome signatures associated with the diagnosis, prognosis and treatment responses in patients with cancer. The mechanisms explaining how dysbiosis compromises natural or therapy-induced immunosurveillance have been explored. Through its integrative approach of leveraging multiple cohorts across populations, cancer types and stages, ONCOBIOME has laid the theoretical and practical foundations for the recognition of microbiota alterations as a hallmark of cancer. ONCOBIOME has launched microbiota-centered interventions and lobbies in favor of official guidelines for avoiding diet-induced or iatrogenic (for example, antibiotic- or proton pump inhibitor-induced) dysbiosis. Here, we review the key advances of the ONCOBIOME network and discuss the progress toward translating these into oncology clinical practice.}, issn = {1078-8956} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wedinmaria_2025, title = {Impact on symptoms and survival of bone metastases in patients with small-intestinal neuroendocrine tumours}, author = {Wedin, Maria and Janson, Eva Tiensuu and Wallin, Göran and Sundin, Anders and Daskalakis, Kosmas}, year = {2025}, journal = {Journal of neuroendocrinology}, volume = {37}, number = {10}, doi = {10.1111/jne.70073}, url = {1991214}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {bone metastases; overall survival; small intestinal neuroendocrine tumours}, abstract = {We aimed to assess the symptoms and impact on overall survival (OS) from bone metastases (BM) diagnosed on Gallium-68-labelled DOTA tyrosine octreotide positron emission tomography with computed tomography (68Ga-DOTATOC-PET/CT) in patients with well-differentiated small intestinal neuroendocrine tumours (Si-NETs). Patients with well-differentiated Si-NETs, who underwent 68Ga-DOTATOC-PET/CT between 2010 and 2023 at two tertiary referral centres in Sweden, were included. Their number of BM, ≤5 BM versus >5 BM, symptoms and need for analgesics were recorded. To further assess the impact of BM on OS, we used a control group of age- and sex-matched Si-NET patients with liver metastases (Stage IV disease) but without BM. The prevalence of BM in Si-NET patients was 23% (175/753); among these, complete clinical data were available in 138 patients. Synchronous BM were found in 33% (46/138). Sixty-one patients (44%) showed >5 BM at the time of BM detection. Fractures were diagnosed in 4% (n = 6) and 14% (n = 20) needed analgesics for BM-associated pain. In univariable analysis, patients with >5 BM experienced shorter OS from the time of BM detection compared to those with ≤5 BM (18 months vs. 75 months, p < .001). Among patients with Stage IV disease with and without BM, OS was shorter in patients with BM compared to patients with no BM (72 months vs. 288 months, p = .002). In multivariable analysis of patients with BM, higher Ki-67% (hazard ratio [HR] = 1.06, p = .007), older age (HR = 1.07, p < .01), presence of >5 BM (HR = 1.93, p = .021) and synchronous BM (HR = 2.14, p = .016) were identified as independent prognostic factors for shorter OS. In the matched cohort of patients with Stage IV disease with and without BM, presence of BM (HR = 1.94, p = .009), age at diagnosis of Stage IV (HR = 1.08, p < .001) and locoregional surgical resection (HR = 0.47, p = .015) were independent prognostic factors for survival. BM are detected in approximately 25% of Si-NET patients subjected to 68Ga-DOTATOC-PET/CT. Pain occurs in approximately 14% and fractures in 4%. The presence of BM among Stage IV patients, the extent of bone disease (>5 BM) and synchronous BM are independent prognostic factors for shorter OS.}, issn = {0953-8194} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_brachmanncoleg_2025, title = {Impacts of large herbivores on mycorrhizal fungal communities across the Arctic}, author = {Brachmann, Cole G. and Ryberg, Martin and Furneaux, Brendan R. and Rosling, Anna and Ou, Tinghai and Ekblad, Alf and Abdulmanova, Svetlana and Barrio, Isabel C. and Bret-harte, M. Syndonia and Fritze, Hannu and Gough, Laura and Hollister, Robert D. and Jónsdóttir, Ingibjörg S. and Kalttopää, Oula and Lindén, Elin and Mäkiranta, Päivi and Olofsson, Johan and Partanen, Rauni and Reid, Kirsten A. and Sokolov, Aleksandr and Sujala, Maija S. and Sundqvist, Maja K. and Suominen, Otso and Tweedie, Craig E. and Young, Amanda and Björk, Robert G.}, year = {2025}, journal = {Ecography}, doi = {10.1002/ecog.08045}, url = {2025449}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {amplicon sequencing; arbuscular mycorrhiza; arctic; ectomycorrhiza; ericoid mycorrhiza; herbivory}, abstract = {Mycorrhizal fungi play an integral role in nutrient and carbon cycling in soils, which may be especially important in the Arctic, one of the world's most soil carbon-rich regions. Large mammalian herbivores can influence these fungi through their impacts on vegetation and soil conditions, however the strength and prevalence of these interactions in the Arctic is still uncertain. We collected soils from 15 large mammal exclusion experiments across the Arctic. We sequenced both ITS regions and partial SSU regions using two sets of amplicons to determine the composition of soil mycorrhizal fungal communities. This allowed us to assess how these communities are impacted by exclusion of large mammalian herbivores, plant communities, and climate and soil properties. Large mammalian herbivore exclusion had a significant impact on the arbuscular mycorrhizal (AM) community dissimilarity between sites. The AM community was also influenced by growing season temperature and pH, which may indicate that conditions are becoming more favourable for these species in some Arctic communities. Large herbivore exclusion did not have a coherent impact on ectomycorrhizal and ericoid mycorrhizal fungal community dissimilarity, which were primarily correlated with delta 15N signature in the soil, rather than herbivory, climate, or plant functional types. The consistent detection of arbuscular mycorrhizal fungi identified highlights the need for more thorough evaluations of these communities and their role in Arctic carbon and nutrient dynamics, as these fungi are currently understudied in the Arctic.}, issn = {0906-7590} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_granberganette_2025, title = {Implementation within disability healthcare : Exploring context and organizational readiness}, author = {Granberg, Anette}, year = {2025}, url = {1991755}, language = {eng}, publisher = {Örebro University}, keywords = {barriers; context; disability; facilitators; implementation; intervention; manager; organizational readiness; professionals; staff}, abstract = {People with disabilities have unequal access to healthcare services and greater unmet healthcare needs compared with the general population; moreover, a so-called ‘implementation gap’ exists between recommended practices and the care that is actually provided. This gap is partly due to a lack of context-specific evidence and partly due to challenges in translating existing evidence into practice. Thus, addressing this gap requires a deeper understanding of the contextual and organizational factors that influence implementation. The aim of this dissertation is to explore the roles of context and organizational readiness from the perspective of managers and staff for the implementation of interventions within disability healthcare. The methods comprise qualitative individual interviews (Study 1), focusgroup interviews (Study 2), a mixed-methods systematic literature review (Study 3), and a survey with an embedded mixed-methods design (Study 4).The overall findings showed that workplace culture, staff attitudes, and openness to change facilitated implementation at the micro (local) level, while balancing managerial tasks and managing resistance among staff posed challenges at the meso (organizational) level. Appropriate organizational structure and support systems increased the feasibility and acceptability of new interventions, but barriers such as complex processes, lack of support and time, and insufficient resources were common at the meso level and macro (system) level. Managers’ beliefs about their organization’s readiness for implementation varied depending on management level, organizational type, and experience. To conclude, for successful implementation within disability healthcare, it is necessary to recognize and address contextual and organizational factors at the micro, meso, and macro levels. The findings suggest that effective implementation of interventions depends on supportive leadership, adequate resources, and a culture open to change. When these conditions are met, health outcomes and the quality of care for people with disabilities can be improved.}, file = {https://oru.diva-portal.org/smash/get/diva2:1991755/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_debrunmaryam_2025, title = {Implications of Changing the Diagnostic Criteria for Gestational Diabetes Mellitus (CDC4G) : A Healthcare Cost Analysis Alongside a Stepped Wedge Cluster Randomised Trial}, author = {de Brun, Maryam and Johansson, Naimi and Simmons, David and Montgomery, Scott and Berntorp, Kerstin and Jansson, Stefan P. O. and Wennerholm, Ulla-Britt and Wikström, Anna-Karin and Strevens, Helena and Ahlsson, Fredrik and Sengpiel, Verena and Storck-Lindholm, Elisabeth and Persson, Martina and Petersson, Kerstin and Ursing, Carina and Ryen, Linda and Backman, Helena}, year = {2025}, journal = {British Journal of Obstetrics and Gynecology}, doi = {10.1111/1471-0528.18364}, url = {1997401}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {cost analysis; diagnostic criteria; gestational diabetes mellitus; healthcare resource use}, abstract = {OBJECTIVE: To estimate the effect on healthcare resource use after introducing the World Health Organization diagnostic criteria (WHO-2013) for gestational diabetes mellitus (GDM) compared to former criteria in Sweden (SWE-GDM). DESIGN: A cost-analysis alongside the Changing Diagnostic Criteria for Gestational Diabetes (CDC4G) randomised controlled trial.SETTING: Sweden, with risk-factor based screening for GDM. POPULATION: 47 080 pregnant women and their infants. METHODS: A register-based cost-analysis from a healthcare perspective alongside a stepped-wedge cluster RCT of switching from SWE-GDM to WHO-2013 criteria in 2018. Analyses were made on the population level and repeated in the subgroup affected by the intervention, that is, those with plasma glucose values between SWE-GDM and WHO-2013 criteria. Sensitivity analysis by bootstrapping was performed.MAIN OUTCOME MEASURES: Estimated costs for obstetric surveillance (including GDM-management), delivery and neonatal healthcare until 28 days postpartum. RESULTS: On a population level, the WHO-2013 criteria were associated with increased costs of obstetric surveillance (adjusted mean [bootstrap confidence interval]) €94.0 [24.5-169.1], delivery care €20.4 [-33.5 to 75.4] and neonatal care €331.0 [75.1-589.0] per pregnancy, and in the affected subgroup €606.9 [377.7-872.4], €348.5 [126.0-542.0] and €129.3 [-559.0 to 980.9] respectively.CONCLUSIONS: Implementation of the WHO-2013 criteria in Sweden was associated with increased costs for obstetric surveillance and delivery on a population level, driven by the affected subgroup. The increased costs for neonatal care were associated with large uncertainty. A detailed understanding of the changes in resource use can guide decisions to mitigate cost increases.}, issn = {1470-0328} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisioannis_2025_2, title = {IMPROVEMENT OF FATIGUE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS TREATED WITH DAPIROLIZUMAB PEGOL : 48-WEEK RESULTS FROM A PHASE 3TRIAL}, author = {Parodis, Ioannis and Gordon, C. and Merrill, J. and Schneider, M. and Touma, Z. and Jimenez, T. and Morel, T. and Nejati, M. and Stach, C. and de la Loge, C. and Arnaud, L.}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {84}, number = {Suppl. 1}, pages = {1227--1229}, doi = {10.1016/j.ard.2025.06.505}, url = {1986300}, language = {eng}, publisher = {Elsevier}, keywords = {patient reported outcome measures; randomised controlled trial; clinical trial; quality of life; fatigue}, abstract = {Background: Fatigue is a common manifestation of systemic lupus erythematosus (SLE). It is associated with severe impairments to patients' quality of life, diminishes their function, and can be particularly difficult to treat. Dapirolizumab pegol (DZP) is a novel, polyethylene glycol (PEG)-conjugated antigen-binding fragment (Fab'), lacking an Fc domain. DZP binds CD40L, blocking CD40-CD40L interactions and CD40 activation, and has broad modulatory effects on SLE immunopathology. In the phase 3 PHOENYCS GO trial (NCT04294667) in patients with SLE, DZP resulted in significant improvement in disease activity at Week 48 versus placebo (PBO) and was generally well tolerated [6].Objectives: To report the impact of DZP on patient-reported fatigue in patients with SLE participating in the phase 3 PHOENYCS GO trial.Methods: PHOENYCS GO was a 48-week, global, randomised, double-blind, PBO-controlled trial. Patients aged ≥16 years with moderate-to-severe, active SLE characterised by persistently active or frequently flaring/relapsing-remitting disease activity despite stable standard of care (SOC) medication (antimalarials, glucocorticoids and/or immunosuppressants) were included. Patients were randomised 2:1 to intravenous DZP 24 mg/kg plus SOC medication (DZP+SOC) or PBO+SOC every 4 weeks. Fatigue was assessed using Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue and FATIGUE-PRO, a measure recently developed to capture the patient experience of fatigue in SLE. FACIT-Fatigue assesses levels of fatigue during usual daily activities over the past seven days, based on responses to 13 questions using a five-point Likert scale [8, 9]. The FACIT-Fatigue score ranges from 0 to 52, with lower scores indicating more fatigue and an increase in score over time reflecting improvement. FATIGUE-PRO captures the patient experience of fatigue and consists of 31 items across three scales: Physical Fatigue, Mental Fatigue and Susceptibility to Fatigue. A score ranging from 0 to 100 is calculated for each scale based on patients' responses about how frequently they experienced fatigue in the past seven days, with higher scores indicating more fatigue and a decrease in score over time reflecting improvement. The least squares (LS) mean change from baseline is reported for FACIT-Fatigue at Weeks 12, 24, 36 and 48, and for the three FATIGUE-PRO scales at Weeks 4, 8, 12, 24, 36 and 48. The LS mean, difference between DZP+SOC and PBO+SOC, 95% CIs and p-values were computed using a mixed model for repeated measurements (MMRM). For FACIT-Fatigue, the proportion of patients with an improvement of ≥4 (minimal clinically important difference [MCID]) [10] at Week 48 is also reported. The difference in proportion of responders between DZP+SOC and PBO+SOC, 95% CIs and p-values were estimated and tested using the Cochran-Mantel-Haenszel (CMH) risk difference estimate controlling for stratification factors. All p-values are nominal and were not controlled for multiplicity. Analyses were performed on the full analysis set.Results: Overall, 85.4% of randomised patients receiving DZP+SOC and 79.6% receiving PBO+SOC completed the study to Week 48 on treatment. Baseline fatigue scores were comparable between patients receiving DZP+SOC (n=208) and PBO+SOC (n=107; Table 1). Mean baseline FACIT-Fatigue scores were <30 for both groups (median: DZP+SOC: 28.0; PBO+SOC: 27.0), indicating substantial fatigue. Patients receiving DZP+SOC demonstrated consistently larger LS mean change from baseline in FACIT-Fatigue score, reflecting greater improvement, compared with PBO+SOC at all assessed visits (nominal p<0.05 for all; Figure 1). At Week 48, the LS mean change from baseline in FACIT-Fatigue was 8.9 versus 5.2 for patients receiving DZP+SOC versus PBO+SOC (difference: 3.7; nominal p=0.0024; Figure 1). A greater proportion of patients receiving DZP+SOC (50.5%) achieved an improvement of ≥4 (MCID) in FACIT-Fatigue at Week 48 compared with PBO+SOC (35.5%; difference: 14.5% [95% CI: 3.0, 25.9]; nominal p=0.0131). Similarly, the LS mean change from baseline in scores for all three FATIGUE-PRO scales was greater for patients receiving DZP+SOC compared with PBO+SOC at Week 48 (nominal p<0.05; Figure 1). Greater differences (nominal p<0.05) in patients receiving DZP+SOC compared with PBO+SOC were observed in the Physical Fatigue scale as early as Week 4 and at all visits from Week 12 onwards, in the Mental Fatigue scale at Weeks 36 and 48, and in the Susceptibility to Fatigue scale at all visits from Week 8 onwards.Conclusion: Improvements in FACIT-Fatigue and all FATIGUE-PRO scales were greater in patients treated with DZP+SOC versus PBO+SOC. Alongside the previously reported significant improvements in overall SLE disease activity, these data support the potential of DZP as a valuable treatment option for improving fatigue in SLE.}, issn = {0003-4967} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_garkemaria_2025, title = {Improvements in emotion regulation during cognitive behavior therapy predict subsequent social anxiety reductions}, author = {Garke, Maria Å. and Hentati Isacsson, Nils and Kolbeinsson, Örn and Hesser, Hugo and Månsson, Kristoffer N. T.}, year = {2025}, journal = {Cognitive Behaviour Therapy}, volume = {54}, number = {1}, pages = {78--95}, doi = {10.1080/16506073.2024.2373784}, url = {1883743}, language = {eng}, publisher = {Routledge}, keywords = {emotion regulation; cognitive behavior therapy; social anxiety disorder; therapeutic processes}, abstract = {Individuals with social anxiety disorder (SAD) experience overall emotion regulation difficulties, but less is known about the long-term role of such difficulties in cognitive behavior therapy (CBT) for SAD. Forty-six patients with SAD receiving internet-delivered CBT, and matched healthy controls (HCs; n = 39), self-reported the Difficulties in Emotion Regulation Scale (DERS), Liebowitz Social Anxiety Scale (LSAS-SR), and participated in anticipatory speech anxiety behavioral experiments. Patients were measured at seven time points before, during and after CBT over a total period of 28 months, and HCs at two timepoints. Disaggregated growth curve models with a total of 263 observations were used, as well as intra-class correlation coefficients and regression models. Patients' LSAS-SR and DERS ratings were reliable (ICC = .83 and .75 respectively), and patients, relative to controls, showed larger difficulties in emotion regulation at pre-treatment (p < .001). During CBT, within-individual improvements in emotion regulation significantly predicted later LSAS-SR reductions (p = .041, pseudo-R2 = 43%). Changes in emotion regulation may thus be important to monitor on an individual level and may be used to improve outcomes in future developments of internet-delivered CBT.}, issn = {1650-6073} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kgstrmmari_2025, title = {In pursuit of an actor-centric understanding of policy integration : Theorizing on the sustainability coordinators in local governance}, author = {Kågström, Mari and Hysing, Erik and Svensson, Petra}, year = {2025}, journal = {Journal of Environmental Planning and Management}, doi = {10.1080/09640568.2025.2538186}, url = {1989226}, language = {eng}, publisher = {Routledge}, keywords = {policy integration; change agents; sustainability coordinators; local environmental governance; cross-sector strategists}, abstract = {Policy integration is a key strategy for promoting sustainability, yet recent research calls for more actor-centric approaches to understand it in practice. This article addresses this gap by theorizing on systemic, organizational and individual-level factors that influence how Swedish Sustainability Coordinators engage with critical tasks to integrate sustainability in local governance. Our framework demonstrates how sustainability and governance ideas and norms, organizational positioning, and individual role perceptions influence their use of five key action strategies to integrate sustainability: connecting, problem-solving, protesting, leading and subversive actions. By better understanding what conditions these actors' courses of action, we add important pieces of the theoretical puzzle for understanding processes of policy integration, bring broader insights on local environmental governance, and promote critical reflection among practitioners.}, issn = {0964-0568} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lpezromerolaura_2025, title = {In Search of Conceptual Clarity About the Structure of Psychopathic Traits in Children : A Network-Based Proposal}, author = {López-Romero, Laura and Andershed, Henrik and Romero, Estrella and Cervin, Matti}, year = {2025}, journal = {Child Psychiatry and Human Development}, volume = {56}, pages = {1521--1534}, doi = {10.1007/s10578-023-01649-z}, url = {1832709}, language = {eng}, publisher = {Springer}, keywords = {children; conduct problems; network structure; prediction; psychopathic traits}, abstract = {Psychopathic traits in childhood have been revealed as potential identifiers of risk, being predictive of later forms of behavioral maladjustment. Yet, it is still under debate how psychopathic traits in children should be best conceptualized and which are the core dimensions for construct definition and prediction. The present study aims to examine the structure of psychopathic traits in childhood, and its predictive value, by using a combination of traditional factor analysis and more recent network-based methods. Data on psychopathic traits, as measured by the Child Problematic Traits Inventory (CPTI), were collected in a large sample of children (n = 2454; 48.2% girls), aged 3 to 6 at the onset of the study (Mage = 4.26; SD = 0.91), who were followed-up one and two years later using parent- and teacher-reports. Results showed that psychopathic traits measured via CPTI are best conceptualized as five latent factors encompassing grandiosity, deceitfulness, callousness, impulsivity and need of stimulation, a result that converged across informants and time. Callousness and grandiosity emerged as central traits using network analysis of parent-reports, while deceitfulness was most central using teacher-reports. Finally, callousness, impulsivity and deceitfulness emerged as the best predictors of concurrent, prospective and stable conduct problems. These results provide a refined structure of psychopathic traits in children that better accounts for the core elements of the construct. Additional theoretical and practical implications will be discussed in terms of assessment, diagnostic classification and tailored prevention/intervention.}, issn = {0009-398X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bangmadsenkathrine_2025, title = {In utero exposure to methylphenidate, amphetamines and atomoxetine and offspring neurodevelopmental disorders : a population-based cohort study and meta-analysis}, author = {Bang Madsen, Kathrine and Larsson, Henrik and Skoglund, Charlotte and Liu, Xiaoqin and Munk-Olsen, Trine and Bergink, Veerle and Newcorn, Jeffrey H. and Cortese, Samuele and Lichtenstein, Paul and Kuja-Halkola, Ralf and Chang, Zheng and D'Onofrio, Brian and Hove Thomsen, Per and Klungsøyr, Kari and Brikell, Isabell and Garcia-Argibay, Miguel}, year = {2025}, journal = {Molecular Psychiatry}, volume = {30}, number = {9}, pages = {3885--3894}, doi = {10.1038/s41380-025-02968-4}, url = {1948533}, language = {eng}, publisher = {Springer Nature}, abstract = {The use of Attention-Deficit/Hyperactivity Disorder (ADHD) medications during pregnancy is increasing, raising concerns about potential long-term effects on offspring. This study investigates in utero exposure to methylphenidate, amphetamines and atomoxetine and risk of offspring neurodevelopmental disorders (NDDs). The population-based cohort study identified from Swedish registers included 861,650 children born by 572,731 mothers from 2008-2017. We categorized exposure based on redeemed medication during pregnancy and compared exposed children to those whose mothers discontinued medication before conception. Main outcomes were any NDD, including ADHD and autism spectrum disorder (ASD). Cox proportional hazards regression estimated hazard ratios (HRs), adjusting for maternal psychiatric and sociodemographic factors. Sensitivity analyses included stratifications by medication type, timing, and duration of exposure, and sibling comparisons. We also performed a meta-analysis combining data from the present study with those from a previous Danish study. Results showed no increased risk for any NDD (HRadjusted 0.95, 95% CI 0.82-1.11), ADHD (HRadjusted 0.92, 95% CI 0.78-1.08), or ASD (HRadjusted 0.86, 95% CI 0.63-1.18). Sensitivity analyses showed consistent patterns of no increased risks across different exposure durations, medication types and between siblings. Meta-analyses further supported the findings (pooled HR for any NDD 1.00, 95% CI 0.83;1.20). Our study provides evidence that in utero exposure to ADHD medications does not increase the risk of long-term NDDs in offspring. This study replicates safety data for methylphenidate and extends it with new safety data on amphetamines and atomoxetine. These findings are crucial for informing clinical guidelines and helping healthcare providers and expectant mothers make informed decisions.}, issn = {1359-4184} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kerezoudievangelian_2025_2, title = {In vitro fermentation of whole matrix, digested products and β-glucan enriched extract of Pleurotus eryngii mushrooms distinctively impact the fecal microbiota of healthy older adults}, author = {Kerezoudi, Evangelia N. and Vlassopoulou, Marigoula and Mitsou, Evdokia K. and Saxami, Georgia and Koutrotsios, Georgios and Taflampa, Ioanna and Mountzouris, Konstantinos C. and Rangel, Ignacio and Brummer, Robert J. and Zervakis, Georgios I. and Pletsa, Vasiliki and Georgiadis, Panagiotis and Kyriacou, Adamantini}, year = {2025}, journal = {Human nutrition & metabolism}, volume = {40}, doi = {10.1016/j.hnm.2025.200314}, url = {1958688}, language = {eng}, publisher = {Elsevier}, keywords = {pleurotus eryngii mushrooms; faecal microbiota; metabolites; beta-glucans; elderly; prebiotic}, abstract = {Pleurotus eryngii (PE), an edible mushroom rich in bioactive compounds, has been shown to exert immunomodulatory, anti-inflammatory, antioxidant, anti-carcinogenic, anti-microbial, antihepatotoxic and hypolipidemic activities, all important for the well-being of the ageing population. This study assessed in vitro the prebiotic-like effects of multiple forms of this mushroom. An in vitro static batch fermentation was performed for 24 h with faecal inocula from five apparently healthy older adults in the presence of the following PE forms: whole food matrix (PEWS), in vitro digested (PEWSD) and rich in beta-glucans extract (PEWSE). The changes in bacterial communities upon fermentation at family, genera and species level were detected via 16S rRNA Next Generation Sequencing and Quantitative real-time PCR. Short-chain fatty acids (SCFAs) were quantified using gas chromatography (GC), whereas other metabolites were analysed through ultra-high pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). DEseq2 analysis indicated that PEWS presence exhibited the largest impact on faecal microbial families' and genera's abundance compared to negative (noncarbon source) and positive (inulin) controls. Only PEWS significantly increased Bifidobacterium spp. and F. prausnitzii populations, while all three forms robustly increased Bacteroides spp. levels and levels of butyrate, acetate and propionate acids. Statistical significance was set at p < 0.05. Overall, the findings highlight the beneficial effect of PE on intestinal health of older adults supporting its potential incorporation into innovative functional foods. However, additional in vivo studies are required to substantiate these findings before translating them into dietary guidelines or clinical applications.}, issn = {2666-1497} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_klangercecilia_2025, title = {Inactivation of the porB gene reduces the virulence of Neisseria meningitidis in transgenic mice}, author = {Klanger, Cecilia and Deghmane, Ala-Eddine and Eriksson, Lorraine and Säll, Olof and Thulin Hedberg, Sara and Mölling, Paula and Taha, Muhamed-Kheir}, year = {2025}, journal = {BMC Microbiology}, volume = {25}, number = {1}, doi = {10.1186/s12866-025-04246-3}, url = {1990434}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {neisseria meningitidis; porb; carriage; experimental infection; inflammatory cytokines; invasive meningococcal disease; transgenic mice}, abstract = {BACKGROUND: Neisseria meningitidis is a human pathogen, carried asymptomatically in the nasopharynx, that can also cause invasive meningococcal disease. Understanding the carriage/invasiveness balance is crucial, and bacterial genetic factors may impact this balance. A previous genome-wide association study reported that the gene porB class 3 was significantly associated with carriage isolates. This study aimed to examine the impact of porB variants on virulence in carriage and invasive meningococcal isolates.RESULTS: For this, 24 isolates were used (13 invasive and 11 carriage) belonging to different genogroups (B, C, W, Y, and cnl) and selected based on the presence of the genetic variant porB class 2 or class 3. Transgenic BALB/c mice expressing human transferrin were infected intraperitoneally with these isolates. After 3 and 24 h of infection, clinical scores (fur quality, strength, and temperature) and bacterial load in blood were used to evaluate bacterial virulence. The concentrations of inflammatory cytokines were determined from blood. PorB- mutants were created from a carriage and an invasive isolate, and were tested in transgenic mice. The invasive isolates provoked significantly more severe infections compared to the carriage isolates, and the carriage isolates of porB class 3 were significantly less virulent than the invasive isolates of porB class 2 or 3. The invasive PorB- isolate caused milder infections than the parental isolate.CONCLUSIONS: This study confirms the ability of invasive isolates of N. meningitidis to cause more severe infections than carriage isolates in transgenic mice. The porB expressed in invasive isolates seems to contribute to their higher virulence compared to carriage isolates, although this effect may depend on the genomic context. Notably, differences in virulence were mainly observed among serogroup C and W isolates.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_8, title = {Incel Epistemology : On Marginality, Experience and Legitimization of Knowledge}, author = {Johansson Wilén, Evelina}, year = {2025}, journal = {Young - Nordic Journal of Youth Research}, volume = {33}, number = {5}, pages = {459--475}, doi = {10.1177/11033088241295873}, url = {1915652}, language = {eng}, publisher = {Sage Publications}, keywords = {consciousness-raising; experience; feminism; feminist standpoint theory; incels; marginality; movements and counter-movements; privileged knowledge; vulnerability}, abstract = {This article contributes to the growing corpus of knowledge concerning the incel movement by scrutinizing how claims of marginalization are mobilized in online incel communities to present incels as privileged subjects of knowledge. The study elucidates how incel marginalization is wielded as a legitimizing experience, conferring epistemic privilege upon self-identifying incels by distinguishing between an ‘us’ of marginalized and enlightened incels, and a ‘them’ consisting of duped and privileged ‘others’. It also examines the role of partaking in incel discussions and incel ideology to achieve an incel standpoint, where lived experience is transformed into counter-hegemonic knowledge. Inspired by social movement theory, the article points to similarities between the incel movement’s political mobilization of marginalized experience and feminist standpoint theory and feminist practices in consciousness-raising groups. It argues that this affinity can be understood from the perspective of the dynamic between movements and counter-movements and their tendency to mimic and copy each other’s tactics.}, issn = {1103-3088} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_9, title = {Incel-mannen är hatisk – och ensam}, author = {Johansson Wilén, Evelina}, year = {2025}, journal = {Nerikes Allehanda}, number = {28 januari}, url = {1996194}, language = {swe}, publisher = {Nerikes allehanda AB}, issn = {1103-971X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kalnelin_2025, title = {Incidence and risk factors for postoperative vaginal events following radical cystectomy for bladder cancer : a nationwide population-based study}, author = {Kalén, Elin and Ginstman, Charlotte and Liedberg, Fredrik and Hagberg, Oskar and Holmbom, Martin and Jerlström, Tomas and Jahnson, Staffan and Gårdmark, Truls and Ströck, Viveka and Holmberg, Lars and Häggström, Christel and Aljabery, Firas}, year = {2025}, journal = {BJU International}, volume = {136}, number = {6}, pages = {1128--1136}, doi = {10.1111/bju.70004}, url = {1999637}, language = {eng}, publisher = {Wiley-Blackwell}, keywords = {bladder cancer; cumulative incidence; radical cystectomy; risk factor; vaginal events}, abstract = {OBJECTIVE: To estimate the probability of vaginal events (diagnosis and/or surgery) following radical cystectomy (RC) and explore possible risk factors in a nationwide population-based observational registry based study.PATIENTS AND METHODS: Women undergoing RC for urinary bladder cancer in Sweden, from 1 January 1997 to 31 December 2019, were identified within national registries. Women with any postoperative vaginal event (PVE), either a diagnosis or surgical repair related to a vaginal complication, were identified using diagnostic and treatment codes. The probability of developing a PVE was estimated based on the cumulative incidence proportion using a competing risk model. Additionally, a multivariable Cox proportional hazards model was used to explore the risk factors for PVEs. Subgroup analysis was performed in patients operated from 2011 to 2019, where additional perioperative variables were registered.RESULTS: The study encompassed 1914 women with a median age of 69 years at the time of bladder cancer diagnosis. The 5-year cumulative risk of PVEs in the entire cohort was 11% (95% confidence interval [CI] 9.5-12.5%). Subgroup analysis showed that robot-assisted RC and a body mass index (BMI) >30 kg/m2 were more often associated with PVEs after RC (hazard ratio [HR] 2.82, 95% CI 1.81-4.40; and HR 1.71, 95% CI 1.05-2.79, respectively).CONCLUSIONS: A clinically relevant cumulative incidence of PVEs following RC was identified. An association between robot-assisted RC or high BMI with increased risk of a PVE indicate the need for further studies on risk assessment of vaginal complications.}, issn = {1464-4096} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wickbomanders_2025_1, title = {Incidence of atrial fibrillation after coronary artery bypass graft surgery and percutaneous coronary intervention : a prospective 2-year follow-up observational study}, author = {Wickbom, Anders and Fengsrud, Espen and Alfredsson, Joakim and Engdahl, Johan and Kalm, Torbjörn and Ahlsson, Anders}, year = {2025}, journal = {BMJ Open}, volume = {15}, number = {11}, doi = {10.1136/bmjopen-2025-106364}, url = {2017577}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {adult cardiology; cardiac surgery; coronary heart disease; coronary intervention; ischaemic heart disease}, abstract = {BACKGROUND: Atrial fibrillation is a common arrhythmia in patients with ischaemic heart disease. New-onset atrial fibrillation after coronary revascularisation is associated with adverse cardiovascular outcomes. This study aimed to determine the long-term cumulative incidence of new-onset atrial fibrillation after percutaneous coronary intervention or coronary artery bypass grafting surgery.METHODS: A prospective observational cohort study in a real-world population setting, conducted at three tertiary centres, on new-onset atrial fibrillation incidence after percutaneous coronary intervention (N=123) or coronary artery bypass grafting (N=123). Heart rhythm was monitored the first 30 days in hospital by telemetry and on discharge using a handheld thumb ECG device three times a day, and thereafter for 2-week periods at 3, 12 and 24 months. The primary endpoint was the cumulative incidence of new-onset atrial fibrillation 24 months after the index procedure. Secondary objectives were to describe the incidence of cerebral ischaemic stroke and bleeding, myocardial infarction and major bleeding events during 24 months follow-up.RESULTS: Mean age was 67 years, and male sex was more prevalent. At 30 days, the cumulative incidence of atrial fibrillation was 56% (69/123) in the coronary artery bypass graft group and 2% (3/123) in the percutaneous coronary intervention group. At 24 months, the cumulative incidence of atrial fibrillation was 58% (71/123) in the coronary artery bypass graft group and 6% (7/123) in the percutaneous coronary intervention group. Stroke, myocardial infarction and major bleeding were infrequent during follow-up.CONCLUSION: Over 24 months of follow-up, incident new-onset atrial fibrillation mainly occurred during the first 30 days after coronary artery bypass grafting but was more evenly distributed during 24 months after percutaneous coronary intervention.TRIAL REGISTRATION NUMBER: NCT04307225.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_janslina_2025, title = {Incidence of de novo HPV infections in a previous HPV-negative group, related to use of different contraceptive methods : a retrospective cohort study}, author = {Jans, Lina and Brynhildsen, Jan and Hofgaard, Joar and Ansari, Safia and Eklöf, Lovisa and Bergengren, Lovisa}, year = {2025}, journal = {Infectious Agents and Cancer}, volume = {20}, number = {1}, doi = {10.1186/s13027-025-00688-6}, url = {1990503}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {contraception; human papillomavirus; intrauterine device; uterine cervical dysplasia}, abstract = {BACKGROUND: Users of intrauterine devices (IUDs) have been found to have a lower incidence of cervical cancer in meta-analyses, but these studies have not been able to examine the influence of IUD type. The aim of this study is to investigate the incidence of de novo high-risk human papillomavirus (HPV) infections in relation to the reported use of contraceptive methods, with special regard to different types of IUDs.METHODS: A sample of participants in the national screening program for cervical cancer (n = 11,702) with a negative HPV test in 2017-2018 were included. Their subsequent HPV test results in 2020-2023 were analyzed in relation to their reported contraceptive method.RESULTS: Participants who reported use of hormonal contraception had higher incidence of a positive HPV screening test (5.6%) compared with women with no reported contraception (4.2%) (OR 1.29; 95% CI 1.01-1.64). There was no significant difference in HPV incidence among women who reported use of hormonal IUD (HIUD) or copper-containing IUD (CU-IUD). Women who reported use of the same contraceptive method in both screening rounds showed no significant differences in HPV incidence, regardless of the contraceptive method they had used.CONCLUSION: The incidence of de novo HPV infections is not significantly different in users of different types of IUD.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_yavropouloumariap_2025, title = {Incidence of fractures in patients with solid cancers treated with immune checkpoint inhibitors : a systematic review and meta-analysis of randomised controlled trials}, author = {Yavropoulou, Maria P. and Anastasilakis, Dimitrios A. and Kasdagli, Maria-Iosifina and Gialouri, Chrysoula G. and Palaiopanos, Konstantinos and Fountas, Athanasios and Anastasilakis, Athanasios D. and Daskalakis, Kosmas and Dekkers, Olaf M. and Lems, Willem F. and Papapoulos, Socrates E. and Makras, Polyzois}, year = {2025}, journal = {BMJ oncology}, volume = {4}, number = {1}, doi = {10.1136/bmjonc-2025-000868}, url = {2018132}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {chemotherapy; immunotherapy}, abstract = {OBJECTIVE: Immune checkpoint inhibitors (ICIs) have revolutionised cancer treatment but can cause several immune-related adverse events. Case reports and population-based studies have reported that ICI treatment may also be associated with higher incidence of fractures, but this has not been systematically studied. The aim of the study is to examine whether treatment with ICIs increases the incidence of fractures compared with chemotherapy or placebo.METHODS AND ANALYSIS: Electronic databases (PubMed, Embase and Cochrane Library) were systematically searched for randomised controlled trials (RCTs), including an ICI monotherapy arm and a placebo/chemotherapy arm, published from database inception to December 2024. Only patients with solid tumours were included. The review protocol was registered in the PROSPERO database (CRD42023448831). Aggregated data were pooled for meta-analysis. The primary outcome was the incidence of clinical, non-pathological fractures in patients with solid cancer treated with ICIs compared with those treated with chemotherapy, placebo or no treatment. Risk of bias was evaluated with the Cochrane Risk of Bias V.2.0 tool.RESULTS: A total of 30 RCTs were identified involving 19 407 patients, of whom 10 076 were ICI users and 9331 non-ICI controls. Among 121 patients with fractures, 68 were ICI users and 53 non-ICI controls. compared with controls, ICI users had a non-significant 18% higher fracture incidence (OR 1.18, 95% CI 0.82 to 1.70). In the subgroup analysis, fracture incidence was 47% higher in ICI users compared with chemotherapy users (OR 1.47, 95% CI 0.93 to 2.32, n=19 studies) but 20% lower compared with placebo users (OR 0.80, 95% CI 0.44 to 1.48, n=10 studies).CONCLUSION: Our analysis suggests an 18% increase in the incidence of clinical non-pathological fractures in ICI users compared with non-ICI controls, although with considerable uncertainty due to wide CIs. Given the small number of reported fractures in RCTs, continued research is warranted to monitor fracture incidence in this patient population.PROSPERO REGISTRATION NUMBER: CRD42023448831.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_akhtarzubair_2025, title = {Incidence of Recurrent Adverse Cardiovascular Events Among Patients With Acute Myocardial Infarction During the First Wave of the COVID-19 Pandemic in Bangladesh : A Prospective Observational Study}, author = {Akhtar, Zubair and Chowdhury, Fahmida and Aleem, Mohammad Abdul and Rahman, Mahmudur and Rahman, Mustafizur and Rahman, Mohammed Ziaur and Hossain, Mohammad Enayet and Islam, A. K. M. Monwarul and Uddin, Mir Jamal and Moa, Aye and Kabir, Alamgir and Tan, Timothy C. and MacIntyre, C. Raina and Fröbert, Ole}, year = {2025}, journal = {Health Science Reports}, volume = {8}, number = {9}, doi = {10.1002/hsr2.71254}, url = {2001339}, language = {eng}, publisher = {John Wiley & Sons}, abstract = {BACKGROUND AND AIMS: COVID-19 is an independent risk factor for cardiovascular disease. We investigated undiagnosed COVID-19 and its effect on recurrent adverse cardiovascular events among patients with acute myocardial infarction (AMI).METHODS: We enrolled patients with either ST-segment elevation (STEMI) or non ST-segment elevation myocardial infarction (NSTEMI) presenting at the National Institute of Cardiovascular Disease, Dhaka, from June 28 to August 11, 2020. Nasopharyngeal swabs were collected for SARS-CoV-2 testing by rRT-PCR at enrolment. We followed all patients from admission until February 7, 2021, before the COVID-19 vaccination in Bangladesh, to register clinical endpoints (all-cause death, new AMI, heart failure, or new revascularization). Demographic information, cardiovascular risk factors, and clinical data were registered. Incidence rate (IR) per 100 person-years follow-up was calculated for clinical endpoints. Poisson regression was employed to estimate the incidence rate ratio (IRR) for SARS-COV-2 infection, adjusting for age.RESULTS: We enrolled 280 patients with a mean age of 54.5 ( ± SD,11.8) years, and 78.6% were males. Of them, 12.9% had undiagnosed SARS-CoV-2 infection and were diagnosed with STEMI (n = 140, 50.0%) and NSTEMI (n = 140, 50.0%). We found that the IR per 100 person-years of all cause death was 35.2, 95% CI: 25.6 to 48.5; recurrent AMI was 18.5, 95% CI: 12.1 to 28.2; heart failure was 6.7, 95% CI: 3.3 to 13.5; and revascularization was 23.5, 95% CI: 16.1 to 34.3. Patients with COVID-19 had numerically higher IRRs for heart failure (2.40, 95% CI: 0.47 to 12.09, p = 0.290) and revascularization (1.11, 95% CI: 0.37 to 3.3, p = 0.853) compared to those without COVID-19, though these differences were not statistically significant.CONCLUSION: This study provides updated data on undiagnosed cases among AMI patients during the first wave of the COVID-19 pandemic. Our findings emphasize the need for further research to explore the impact of COVID-19 on AMI patients in resource-limited settings like Bangladesh.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ahlqvistsandra_2025, title = {Incidence of ventral hernia surgery after laparoscopic bariatric surgery in Sweden : a registry-based study 2009-2019}, author = {Ahlqvist, Sandra and Walldén, Jakob and Blixt Dackhammar, Johan and Nordin, Pär and Wadsten, Charlotta and Ottosson, Johan and Cengiz, Yücel}, year = {2025}, journal = {Hernia}, volume = {30}, number = {1}, doi = {10.1007/s10029-025-03547-w}, url = {2023922}, language = {eng}, publisher = {Springer}, keywords = {bariatric surgery; complications; incisional hernia; laparoscopy; port site hernia; trocar site hernia}, abstract = {PURPOSE: The incidence of trocar site hernia (TSH) after bariatric surgery is unclear. This study aims to describe the cumulative incidence of ventral hernia surgery after laparoscopic bariatric surgery in total and by laparoscopic method (LRYGB; Roux-en-Y Gastric Bypass and LSG; Sleeve Gastrectomy).METHODS: This was a register based observational study on patients subjected to laparoscopic bariatric surgery (LRYGB or LSG) in Sweden 2009-2019. The Scandinavian Obesity Surgery Registry (SOReg) was linked to the Swedish National Patient Register (NPR) to obtain instances of ventral hernia surgery. Nearby codes were used as proxies for TSH surgery, since a specific procedure code for TSH surgery is lacking.RESULTS: In 64 124 patients, mean follow-up was 67 ± 36 months, LRYGB (n = 52 020) 74 ± 34 months and LSG (n = 12 104) 34 ± 22 months. Mean time between bariatric- and ventral hernia surgery was 36 ± 28 months (range 0-129). The five-year cumulative incidence of surgery for ventral hernia was 2.9% (CI 2.8-3.1). The probability of having hernia surgery was significantly higher for LRYGB compared to LSG (Breslow test, p < 0.001), still significant with differences in follow-up time accounted for (p < 0.001).CONCLUSION: The incidence of surgery for ventral hernia after laparoscopic bariatric surgery is not negligible in this material covering over a decade of bariatric procedures. Ventral hernia surgery was more common after gastric bypass than after sleeve gastrectomy.}, issn = {1265-4906} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wangxinchen_2025, title = {Incident benzodiazepine and Z-drug use and subsequent risk of alcohol- and drug-related problems : A nationwide matched cohort study with co-twin comparison}, author = {Wang, Xinchen and Chang, Zheng and Molero, Yasmina and Isomura, Kayoko and Fernández de la Cruz, Lorena and Lichtenstein, Paul and Kuja-Halkola, Ralf and D'Onofrio, Brian M. and Quinn, Patrick D. and Larsson, Henrik and Brikell, Isabell and Hellner, Clara and Hasselström, Jan and Jayaram-Lindström, Nitya and Mataix-Cols, David and Sidorchuk, Anna}, year = {2025}, journal = {Journal of Psychopharmacology}, doi = {10.1177/02698811251373069}, url = {2003103}, language = {eng}, publisher = {Sage Publications}, keywords = {z-drugs; alcohol use disorders; benzodiazepines; drug use disorders}, abstract = {BACKGROUND: Despite considerable interest in the consequences of benzodiazepine and benzodiazepine-related Z-drug (BZDR) use, little is known about whether and how initiation of BZDR treatment relates to the development of alcohol- and drug-related problems. AIMS: This study aimed to examine the association of incident BZDR dispensing with subsequent alcohol- and drug-related problems.METHODS: This nationwide register-based study included demographically matched and co-twin control cohorts. Among all Swedish residents aged older than 10 years and BZDR-naïve by 2007, 960,430 BZDR-recipients with incident dispensation in 2007-2019 and without any recorded pre-existing substance-related conditions were identified and matched (1:1) to non-recipients from the general population. Twin BZDR-recipients (n = 12,048) were linked to 12,579 unexposed co-twins. Outcomes included alcohol and drug use disorders, poisoning, deaths, and related suspected criminal offences. Flexible parametric survival models estimated outcome risks across up to 14 years of follow-up.RESULTS: In the demographically matched cohort (60% women, median age at BZDR initiation 51 years), incidence rates in BZDR-recipients and non-recipients (per 1000 person-years) were 5.60 versus 2.79 for alcohol-related and 4.15 versus 1.23 for drug-related problems, respectively. In fully adjusted models, relative risks were increased for alcohol- and drug-related problems (adjusted hazard ratio (95% confidence interval): 1.56 (1.53-1.59) and 2.11 (2.05-2.17), respectively). The risks persisted within the co-twin comparison, different follow-ups, and all additional sensitivity analyses.CONCLUSIONS: BZDR initiation was associated with a small but robust increase in absolute and relative risks of developing alcohol- and drug-related problems. The findings contribute to evidence base for making decisions on BZDR treatment initiation.}, issn = {0269-8811} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stergianosstavros_2025, title = {Income and work loss in patients with Addison's disease : a nationwide population-based study}, author = {Stergianos, Stavros and Everhov, Åsa H. and Söderling, Jonas and Bergthorsdottir, Ragnhildur and Wahlberg, Jeanette and Skov, Jakob and Bensing, Sophie}, year = {2025}, journal = {European Journal of Endocrinology}, volume = {192}, number = {3}, pages = {170--179}, doi = {10.1093/ejendo/lvaf022}, url = {1947099}, language = {eng}, publisher = {Oxford University Press}, keywords = {addison's disease; work loss; sick leave; disability pension; taxable earnings; disposable income; socioeconomic outcomes}, abstract = {Objective: Autoimmune Addison's disease (AAD) is associated with reduced health-related quality of life and possibly reduced employability. The aim of this study was to assess differences in income and work loss between patients with AAD and matched comparators.Design: Nationwide, cross-sectional register-based study.Methods: By linking the Swedish Addison Register and national health registers, we identified working age (18-64 years) individuals with AAD and general population comparators (matched 1:5 by sex, age, and county of residence). We assessed differences in taxable earnings and disposable income through quantile regression and differences in work loss through linear regression during 2019.Results: We identified 1140 cases with AAD and 5700 comparators (mean age 46.1 years, 48.4% men). Type 1 diabetes was prevalent in 15.7% and 1.1%, respectively. Work loss was higher in AAD; adjusted mean difference 14.4 days; 95% CI, 8.6-20. The adjusted median differences in taxable earnings and disposable income were non-significant overall at -617 (95% CI; -2317 to 1083) and -405 (95% CI; -1417 to 607) . However, significantly lower taxable earnings and disposable income were found among patients with short education: -5303 (95% CI; -9603 to -992) and -3754 (95% CI; -6486 to -1022) , or concomitant type 1 diabetes: -5808 (95% CI; -9937 to -1690) and -3349 (95% CI; -6203 to -506) .Conclusion: Patients with AAD had more work loss, yet overall similar taxable earnings and disposable incomes versus comparators. Patients with AAD with shorter education or type 1 diabetes were most socioeconomically vulnerable.}, issn = {0804-4643} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bodnarolha_2025_2, title = {Incorporating Different Sources of Information for Bayesian Optimal Portfolio Selection}, author = {Bodnar, Olha and Bodnar, Taras and Niklasson, Vilhelm}, year = {2025}, journal = {Journal of business & economic statistics}, volume = {43}, number = {2}, pages = {365--377}, doi = {10.1080/07350015.2024.2379361}, url = {1904414}, language = {eng}, publisher = {Taylor & Francis}, keywords = {conjugate prior; epu; high-frequency data; jeffreys' prior; value-weighted portfolio; vix}, abstract = {This article introduces Bayesian inference procedures for tangency portfolios, with a primary focus on deriving a new conjugate prior for portfolio weights. This approach not only enables direct inference about the weights but also seamlessly integrates additional information into the prior specification. Specifically, it automatically incorporates high-frequency returns and a market condition metric (MCM), exemplified by the CBOE Volatility Index (VIX) and Economic Policy Uncertainty Index (EPU), significantly enhancing the decision-making process for optimal portfolio construction. While the Jeffreys' prior is also acknowledged, emphasis is placed on the advantages and practical applications of the conjugate prior. An extensive empirical study reveals that our method, leveraging this conjugate prior, consistently outperforms existing trading strategies in the majority of examined cases.}, issn = {0735-0015} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lushnikovaalexandra_2025, title = {Increased Colonic Levels of CD8+ Cytotoxic T lymphocyte-Associated Mediators in Patients With Microscopic Colitis}, author = {Lushnikova, Alexandra and Wickbom, Anna and Bohr, Johan and Kruse, Robert and Wirén, Anders and Hultgren Hörnquist, Elisabeth}, year = {2025}, journal = {Inflammatory Bowel Diseases}, volume = {31}, number = {8}, pages = {2231--2243}, doi = {10.1093/ibd/izaf064}, url = {1951465}, language = {eng}, publisher = {Oxford University Press}, keywords = {cd8+ t lymphocytes; colonic biopsies; colorectal cancer; microscopic colitis; ulcerative colitis}, abstract = {BACKGROUND: For unidentified reasons, possibly due to increased immune surveillance, patients with collagenous colitis (CC) and lymphocytic colitis (LC), both forms of microscopic colitis (MC), have lower risk of colorectal cancer than controls and ulcerative colitis (UC) patients. Levels of secreted and cell-bound mediators in MC patients with active disease and in histological remission (HR) compared to UC patients and controls were investigated.METHODS: Median fluorescence intensity of 54 analytes in colonic biopsies from patients with active CC (n = 21), LC (n = 11), and UC (n = 19); CC-HR (n = 6), LC-HR (n = 9), UC in remission (n = 19), non-diarrhea controls (n = 48), and diarrhea controls (n = 25) was measured using Luminex.RESULTS: Granzyme B and CCL5 levels were higher in active CC than in UC, whereas CCL4 and CD163 levels were similar in CC and UC, and both groups had higher levels of matrix metalloproteinase (MMP)-1, MMP-3, and tumor necrosis factor receptor II than both control groups. APRIL, BAFF, BCMA, CCL20, CXCL8, chitinase 3-like 1, pentraxin-3, Fas, and IL-33 were higher in UC than MC. Increases in 4-1BB and perforin in MC compared to controls were lower than in UC. Levels of gp130 and IL-6Rα were decreased in MC but increased in UC compared to controls.CONCLUSIONS: Microscopic colitis patients exhibit increased levels of several analytes, including some associated with CD8+ T lymphocytes, suggesting a different pathogenesis of MC compared to UC. Higher levels of MMP-1 and MMP-3 in CC than LC indicate separate disease entities.}, issn = {1078-0998} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kessonellen_2025, title = {INCREASED FREQUENCY OF HYPOGLYCEMIC EVENTS MAY CONTRIBUTE TO ELEVATED FRACTURE INCIDENCE IN YOUNG INDIVIDUALS WITH TYPE 1 DIABETES}, author = {Åkesson, Ellen and Lyckå, Auste Pundziute and Michno, Piotr and Thorén, Alexander and Särnblad, Stefan and Hanås, Ragnar and Åkesson, Karin}, year = {2025}, journal = {Diabetes Technology & Therapeutics}, volume = {27}, number = {Suppl. 2}, pages = {E64--E65}, url = {2038348}, language = {eng}, publisher = {Mary Ann Liebert}, abstract = {Background and Aims: This study aims to compare the incidence of fractures in young T1D individuals vs controls and to explore the association between the frequency of hypoglycemic events and fracture incidence. Previous research has indicated an elevated fracture incidence among individuals with T1D. The predominant hypothesis attributes this increased risk to a higher prevalence of osteoporosis.Methods: Data on 22,077 (55% males) individuals diagnosed with T1D before the age of 18 years were retrieved from the Swedish National Diabetes Register (NDR) and compared with 110,390 age- and sex-matched controls.Results: There is a significantly increased risk of fractures in T1D individuals compared to controls (Figure1). This elevated risk isńt seen before T1D diagnosis but is apparent already within the first few years after diagnosis. It is observed in both sexes, with females’ relative risk (RR) 1.4 (95%CI 1.35-1.47) and males’ RR 1.27 (95%CI 1.23-1.30) during the follow up period. In the National Patient Register 0.56 hypoglycemic events/T1D individual with at least one fracture vs 0.3/T1D individual without any fracture were reported. Mean age in the fracture group was 27 years, compared to 22 years in the non-fracture group. A logistic regression model, adjusted for age and duration of T1D, still showed a significantly higher frequency of hypoglycemic events throughout the follow-up period (p < 0.03).Image (.png) is missing or otherwise invalid.Conclusions: The increased incidence of fractures in individuals with T1D may, to some extent, be attributed to a higher risk of accidents resulting from hypoglycemic events. Continuous glucose monitoring systems with alarms could be crucial tools to reduce this risk.}, issn = {1520-9156} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_horwathoscar_2025, title = {Increased muscle satellite cell content and preserved telomere length in response to combined exercise training in patients with FSHD}, author = {Horwath, Oscar and Montiel Rojas, Diego and Ponsot, Elodie and Féasson, Léonard and Kadi, Fawzi}, year = {2025}, journal = {Journal of Physiology}, volume = {603}, number = {5}, pages = {1057--1069}, doi = {10.1113/JP287033}, url = {1935129}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {pax7; facioscapulohumeral muscular dystrophy; muscle fibre; muscle regeneration; myogenesis}, abstract = {Facioscapulohumeral muscular dystrophy (FSHD) is an inherited muscle disease characterized by weakness and muscle wasting. In the absence of available treatments, exercise training has emerged as a potential strategy to attenuate muscle tissue deterioration. However, little is known about the impact of chronic exercise on degenerative events and regenerative capacity in FSHD muscle. Muscle biopsies were obtained from 16 FSHD patients before and after a 24 week training program combining aerobic-, strength- and high-intensity exercise (Control; n = 8, Training; n = 8). Histochemical and immunohistochemical approaches were applied to assess histopathological signs, markers of regeneration, inflammatory infiltrates and satellite cell content. Muscle telomere length was measured as an indicator of the remaining regenerative capacity. The proportion of muscle fibres expressing developmental myosins and centralized myonuclei was not exacerbated after the intervention. Similarly, no alterations were observed in the number of inflammatory infiltrates (CD68+ cells). Alongside muscle hypertrophy in slow (P = 0.022) and fast fibres (P = 0.022 and P = 0.008), satellite cell content increased specifically in fast fibres (+75 %, P = 0.015), indicating a functional satellite cell pool in FSHD muscle. Importantly, exercise training was not associated with a shortening of muscle telomere length, suggesting that muscle cell turnover was not accelerated despite an expansion of the satellite cell pool. Our findings suggest that combined exercise training elicits beneficial muscular adaptations without impairing important indicators of skeletal muscle regenerative capacity in patients with FSHD. KEY POINTS: A 24 week combined exercise training program is a safe and well-tolerated strategy to attenuate skeletal muscle deterioration in facioscapulohumeral muscular dystrophy (FSHD) patients. Markers of histopathology, muscle fibre regeneration and inflammatory infiltrates were not exacerbated following exercise training in FSHD muscle. Here, we show novel data that exercise training in FSHD patients induced muscle fibre hypertrophy and triggered an expansion of the satellite cell pool specifically in fast fibres. Exercise training in these patients is not associated with a shortening of muscle telomere length thereby indicating a preserved capacity for muscle regeneration.}, issn = {0022-3751} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lilin_2025, title = {Increased Prescribing of Attention-Deficit/Hyperactivity Disorder Medication and Real-World Outcomes Over Time}, author = {Li, Lin and Coghill, David and Sjölander, Arvid and Yao, Honghui and Zhang, Le and Kuja-Halkola, Ralf and Brikell, Isabell and Lichtenstein, Paul and D'Onofrio, Brian M. and Larsson, Henrik and Chang, Zheng}, year = {2025}, journal = {JAMA psychiatry}, volume = {82}, number = {8}, pages = {830--837}, doi = {10.1001/jamapsychiatry.2025.1281}, url = {1977426}, language = {eng}, publisher = {American Medical Association (AMA)}, abstract = {IMPORTANCE: The prescription of attention-deficit/hyperactivity disorder (ADHD) medications has risen substantially in many countries over the last 20 years. However, whether the real-world benefits of ADHD medications change with increased prescription rates within a society remains unknown. OBJECTIVE: To examine whether the associations between ADHD medications and real-world outcomes (self-harm, unintentional injury, traffic crashes, and crime) change as prescription rates rise.DESIGN, SETTING, AND PARTICIPANTS: This study used a self-controlled case series design. It was a population-based study using Swedish National Registers that included individuals who used ADHD medications in Sweden between 2006 and 2020. Data were analyzed from October 2023 to November 2024. EXPOSURE: ADHD medication use.MAIN OUTCOMES AND MEASURES: Rates of self-harm, unintentional injury, traffic crashes, and crime during medicated vs nonmedicated periods. The associations between ADHD medication and these real-world outcomes were examined across 3 time periods, 2006 to 2010, 2011 to 2015, and 2016 to 2020, during which ADHD medication prevalence increased from 0.6% to 2.8%. RESULTS: There were 247 420 individuals identified (99 361 females [40.2%] and 148 059 males [59.8%]) aged 4 to 64 years in Sweden who used ADHD medications between 2006 and 2020. ADHD medication was consistently associated with lower risks for self-harm (incidence rate ratio [IRR] ranged from 0.77; 95% CI, 0.73-0.81 to 0.85; 95% CI, 0.82-0.88), unintentional injury (IRR ranged from 0.87; 95% CI, 0.84-0.89 to 0.93, 95% CI, 0.91-0.95), traffic crashes (IRR ranged from 0.71; 95% CI, 0.67-0.77 to 0.87; 95% CI, 0.83-0.91), and crime (IRR ranged from 0.73; 95% CI, 0.71-0.75 to 0.84; 95% CI, 0.82-0.85) across different age groups, sexes, and over time. However, the associations between ADHD medication use and lower risks of unintentional injury (P value for trend < .01), traffic crashes (P value for trend < .01), and crime (P value for trend < .01) appear to weaken over time as prescription rates increased. Changes in age and sex distribution of individuals receiving ADHD medication did not fully explain the weakening trend for unintentional injury and traffic crashes.CONCLUSIONS AND RELEVANCE: In this study, ADHD medication remained associated with reduced risks of several serious real-world outcomes. However, the magnitude of these associations appears to have decreased alongside rising prescription rates over time. Thus, it is important to regularly evaluate medication use in different patient populations.}, issn = {2168-6238} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_munshieihab_2025, title = {Increased risk of postoperative complications after delayed stoma reversal : a multicenter retrospective cohort study on patients undergoing anterior resection for rectal cancer}, author = {Munshi, Eihab and Segelman, Josefin and Matthiessen, Peter and Park, Jennifer and Rutegård, Martin and Sjöström, Olle and Jutesten, Henrik and Lydrup, Marie-Louise and Buchwald, Pamela}, year = {2025}, journal = {International Journal of Colorectal Disease}, volume = {40}, number = {1}, doi = {10.1007/s00384-025-04831-y}, url = {1937339}, language = {eng}, publisher = {Springer}, keywords = {anastomotic leak; anterior resection; defunctioning stoma; postoperative complications; stoma reversal complications; stoma reversal time}, abstract = {PURPOSE: Defunctioning stoma (DS) has been suggested to mitigate the consequences of anastomotic leak (AL) after low anterior resection. Stoma reversal (SR) is commonly delayed for nonmedical reasons in many healthcare systems. This study investigated the impact of the elapsed time from AR to SR on postoperative 90-day complications. The secondary aim was to explore the independent factors associated with a delayed SR. M&M: This multicenter retrospective cohort study included rectal cancer patients who underwent anterior resection (AR) and DS between 2014 and 2018. Multivariable logistic regression was used to evaluate the influence of the elapsed time from AR to SR on postoperative complications within 90 days.RESULTS: Out of 905 patients subjected to AR with DS, 116 (18%) patients experienced at least one postoperative 90-day complication after SR. Multivariable analysis revealed an association between the elapsed time to SR and complications within 90 days from SR (OR 1.02; 95% CI, 1.00-1.04). The association with SR complications was further highlighted in patients who experienced delayed SR > 6 months after AR (OR 1.73; 95% CI, 1.04-2.86). AL after AR and nodal disease were both related to delayed SR.CONCLUSION: This study demonstrated that postoperative 90-day complications are associated with the time elapsed to SR. These findings emphasize the importance of early SR, preferably within 6 months, to prevent complications.}, issn = {0179-1958} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_carlssonsofia_2025, title = {Increasing incidence of early-onset type 2 diabetes in Sweden 2006-2021}, author = {Carlsson, Sofia and Andersson, Tomas and Jansson, Stefan P. O. and Nyström, Thomas and Rolandsson, Olov and Wei, Yuxia}, year = {2025}, journal = {European Journal of Public Health}, volume = {35}, number = {6}, pages = {1258--1263}, doi = {10.1093/eurpub/ckaf114}, url = {1983214}, language = {eng}, publisher = {Oxford University Press}, abstract = {Our aim was to provide new data on the incidence, prevalence, and secular trend of type 2 diabetes (T2D) in Sweden, specifically early-onset T2D. We followed the Swedish population 2006 to 2021 and calculated age-standardized incidence (per 100 000) and prevalence (%) of T2D (overall) and early-onset T2D (age 23-39 years) stratified by sex, region of birth, and educational level. We projected the future prevalence of early-onset T2D by combining observed trends with population projections. From 2006 to 2021, the prevalence of T2D rose from 4.87% to 7.50%, and incidence from 477 [95% confidence interval (CI) 471-482] to 574 (CI 568-579). Early-onset T2D incidence increased from 54 to 107 (4.7% annual rise; CI 3.7%-5.7%) during this period. Incidence of early-onset T2D was higher in individuals born outside Europe (211, CI 195-226 vs 89, CI 84-93 in 2021) or low education (204, CI 185-223 vs 71, CI 65-77 in 2021), but a rise in incidence was seen irrespective of educational level, region of origin, and sex. If the incidence of early-onset T2D continues to increase at the same pace, its prevalence is projected to increase from 0.64% in 2021 to 3.2% in 2050. While T2D incidence rose marginally in Sweden 2006 to 2021, there was a significant rise in early-onset T2D, seen across different socioeconomic characteristics, with prevalence more than doubling and incidence nearly doubling. This development calls for targeted preventive efforts.}, issn = {1101-1262} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vigrenpatrick_2025, title = {Indirect cognitive mapping in glioma surgery in patients not eligible for awake craniotomy : how I do it}, author = {Vigren, Patrick and Lindehammar, Hans}, year = {2025}, journal = {Acta Neurochirurgica}, volume = {167}, number = {1}, doi = {10.1007/s00701-025-06706-1}, url = {2012562}, language = {eng}, publisher = {Springer}, keywords = {cognition; glioblastoma; glioma; intraoperative mapping}, abstract = {This paper illustrates a method to map cognitive subcortical white matter pathways in brain tumour surgery, in patients not eligible for awake intraoperative mapping. The latter being the gold standard, it is not feasible in all patients. Illustrated by three cases, the presented method includes a preoperative mapping of both motor and subcortical eloquent structures - such as arcuate fasciculus and basal ganglia - subsequentially using subcortical motor mapping as a landmark to indirectly identify the cognitive structures.}, issn = {0001-6268} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_olssonemma_2025, title = {Individualized developmental care interventions for promoting development and preventing morbidity in preterm infants}, author = {Olsson, Emma and Prescott, Marcus G. and Titlestad, Kristine B. and Fiander, Michelle and Soll, Roger F. and Bruschettini, Matteo}, year = {2025}, journal = {Cochrane Database of Systematic Reviews}, volume = {1}, doi = {10.1002/14651858.CD016026}, url = {1932178}, language = {eng}, publisher = {John Wiley & Sons}, abstract = {Study protocol} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alsharaahaya_2025, title = {Individual-Level Effects of a Digital Behavioural Treatment for Chronic Pain : Proof-of-Concept of a Single-Case Experimental Design Study}, author = {Al Sharaa, Haya and Bartels, Sara Laureen and Taygar, Afra S. and Engman, Linnea and Petersson, Suzanne and Flink, Ida and Boersma, Katja and McCracken, Lance M. and Simons, Laura and Vlaeyen, Johan W. S. and Onghena, Patrick and Wicksell, Rikard K.}, year = {2025}, journal = {European Journal of Pain}, volume = {29}, number = {10}, doi = {10.1002/ejp.70128}, url = {1999238}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {n‐of‐1; chronic pain; cognitive behavioural therapy; digital; self‐management; single‐case experimental design}, abstract = {BACKGROUND: Chronic pain affects 20%-30% of the population worldwide, leading to significant distress, disability and financial burden. Pain management strategies focusing on pain reduction have shown limited effects on functioning; however, behavioural treatments aimed at enhancing resilience have demonstrated strong empirical support. Digital solutions offer new opportunities for delivering evidence-based treatments, but evaluation at the individual level is needed. The aim of this study is to examine individual-level treatment effects of a digital behavioural treatment for chronic pain in a heterogeneous sample.METHODS: A study with a single-case experimental design (SCED) was conducted with participants (N = 11) experiencing chronic pain (> 3 months) recruited through healthcare. Participants were randomised at baseline (5-10-day A-phase) and completed a 6-module digital treatment based on learning theory and well-established theories applied to chronic pain (6-8-week B-phase), with weekly therapist contact. Digital diaries, prompted twice daily, tracked psychological flexibility and acceptance, pain-related functioning, pain intensity and well-being. Data were analysed using visual analysis and effect size calculations.RESULTS: N = 11 enrolled and data from n = 10 were analysed (n = 1 refused digital diary, n = 2 partial completers, n = 8 full completers). Pain profiles varied (e.g., chronic migraine, fibromyalgia, lower back pain, etc.). Several participants benefited from the treatment, though results varied across individuals and across outcomes.CONCLUSION: The digital behavioural treatment showed promise in addressing diverse pain profiles and associated functioning. The variability in responses highlights the benefit of using SCED to explore individual-level effects, thus offering a methodological proof-of-concept. Findings support further development, including tailoring to match individual needs. SIGNIFICANCE STATEMENT: This proof-of-concept study provides support for the utility of digital behavioural interventions and individual-level evaluation of treatment effects, highlighting the potential of personalised pain treatments. The findings contribute to the growing body of support for digital solutions as effective and accessible approaches to improve functioning and resilience for people with diverse pain experiences.}, issn = {1090-3801} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kallenbornroland_2025, title = {Industrial and public infrastructure as local sources of organic contaminants in the Arctic}, author = {Kallenborn, Roland and Gabrielsen, Geir Wing and Vorkamp, Katrin and Reiersen, Lars-Otto and Evenset, Anita and Pedersen, Kristin B. and Corsolini, Simonetta and Ademollo, Nicoletta and Li, Yifan and Zhang, Zi-Feng and Langberg, Håkon Austad and Hartz, William F. and von Hippel, Frank and Muir, Derek and de Wit, Cynthia A. and Gunnarsdottir, Maria J. and Jensen, Pernille Erland and Kirkelund, Gunvor Marie and Breedveld, Gijsbert and Bengtson Nash, Susan and Lyche, Jan Ludvig and Barbaro, Elena}, year = {2025}, journal = {Environmental Science: Advances}, doi = {10.1039/d5va00261c}, url = {2021220}, language = {eng}, publisher = {Royal Society of Chemistry}, abstract = {Arctic pollution has been a focal point in environmental research over the past five decades. Recently, the number of pollutants identified as relevant to the Arctic has significantly increased. Consequently, the expert group on Persistent Organic Pollutants (POPs) and Chemicals of Emerging Arctic Concern (CEACs) of the Arctic Monitoring and Assessment Programme (AMAP) has prepared a series of assessments of contaminants in the Arctic, including influences of climate change. This review addresses local sources of Arctic organic pollutants associated with infrastructure in the Arctic. Industrial, military, and public infrastructures, including domestic installations, sewage treatment, solid waste management, and airports, were identified as significant local pollution sources. Additionally, operational emissions (e.g., from shipping, transportation, heating, and power production) contribute to the overall local pollution profile. Based on currently available scientific information, elevated POP and CEAC levels are mostly found in close proximity to identified local pollution sources. To date, hazardous effects have only been confirmed for a few selected chemicals, such as polycyclic aromatic compounds (PAC) and certain pharmaceutical residues. However, studies are biased in the sense that they often focus on well-known contaminants, at a risk of overlooking CEAC and their effects. The review identifies several measures to reduce human impacts on local Arctic environments, including (i) using local indicator pollutants in ongoing national monitoring schemes, (ii) harmonizing emission reduction policies and licensing of industrial activities in the region to minimize exposure risks and environmental pollution, (iii) encouraging local municipalities, industries, and related stakeholders to coordinate their activities to minimize pollutant emissions.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_vinayakpatilrajesh_2025_2, title = {Industry V.0: The Significance of Manufacturing Technologies : Industrial Internet of Things, Cloud Computing and Synthetic Intelligence}, author = {Vinayak Patil, Rajesh}, year = {2025}, url = {1993491}, language = {eng}, publisher = {Bentham Science Publishers} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_janssonmaria_2025_1, title = {Inequalities and critical citizenship learning in Swedish upper secondary schools}, author = {Jansson, Maria}, year = {2025}, journal = {Education, Citizenship and Social Justice}, volume = {20}, number = {3}, pages = {417--430}, doi = {10.1177/17461979241281701}, url = {1901700}, language = {eng}, publisher = {Sage Publications}, keywords = {critical citizenship; upper secondary schools; sweden; ethnicity; gender}, abstract = {This article analyses how students in two Swedish upper secondary schools with different demographics articulate inequalities, and how their positions in society give rise to different learning patterns. Using material from focus group interviews undertaken during a teaching module about trust, the article departs from the proposition that learning about trust in school also means negotiating trust and experiences from outside the school context. The article concludes that students who identify as non-ethnic Swedes must bridge the gap between the learning content and their own experiences. Such negotiations allow for a critical view on democratic institutions. However, this critical potential stems from a position that also necessitates more work to ‘learn’ the content provided, compared to the ethnic Swedes who encounter the teaching materials from a position where it can be inserted and combined with an already existing and matching worldview. The article argues that challenging the views and the normative position held by the latter group is a remaining task for citizenship teaching.}, issn = {1746-1979} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hawthornealexis_2025, title = {Inequality, Trust and Fear : Migrant Healthcare During the COVID‐19 Pandemic and Beyond}, author = {Hawthorne, Alexis and Bobek, Alicja and Sandström, Lina}, year = {2025}, journal = {Sociology of Health and Illness}, volume = {47}, number = {7}, doi = {10.1111/1467-9566.70077}, url = {1988650}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {covid‐19; discrimination; europe; health; inequality; migrant; pandemic; trust}, abstract = {Many migrants are considered to be disadvantaged regarding their social, economic and health outcomes. During the COVID-19 pandemic these inequalities grew starker, especially in healthcare, as migrants were at increased risk of exposure and had a reduced ability to seek care or access support. This paper will explore these issues through the analysis of narrative interviews gathered during a large-scale, cross-European project which explored the experiences of 740 marginalised individuals, including migrants, during the COVID-19 pandemic. We build upon Beck's concept of the ‘risk society’ by exploring the ways in which neoliberal states have created exposure to risk; however, we also adopt a critical approach in examining how risk is not distributed equally. The following themes were revealed: first, migrants were often more exposed to the virus due to their occupational status. Second, migration status had an impact on access to healthcare, with undocumented migrants especially vulnerable. Third, the intersection between health crises and trust was identified: on the one hand, migrants lack of trust in host country institutions affected their engagement with services; on the other, they also experienced a lack of trust in them, as they were often perceived as a ‘risk’ in relation to the virus.}, issn = {0141-9889} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_calatravanicolsfranciscom_2025, title = {Inertial Sensor-Based Hierarchical Contrastive Multi-View Learning for Human Activity Recognition}, author = {Calatrava Nicolás, Francisco M. and Fortes Rey, Vitor and Lukowicz, Paul and Martínez Mozos, Oscar}, year = {2025}, pages = {106--112}, doi = {10.1145/3715071.3750416}, url = {2015883}, language = {eng}, publisher = {Association for Computing Machinery (ACM)}, keywords = {human activity recognition; multi-view; ensemble; contrastive learning; inter-subject variability; self-placement variability}, abstract = {This paper addresses Human Activity Recognition (HAR) using wearable inertial sensors, where model generalization to unseen individuals remains challenging owing to multiple sources of data heterogeneity. To mitigate this, we introduce a sensor-based hierarchical multi-view framework that defines each view as the set of sensors positioned symmetrically on the body. This framework uses a shared encoder across all views to learn view-invariant representations, while view-specific heads are used to capture view-dependent nuances. We reinforce cross-view consistency and view sensitivity through supervised contrastive learning at two hierarchy levels: the shared encoder and the view-specific heads. Our method yields macro F1 gains of 0.7-12.4 percentage points (pp) over state-of-the-art baselines in multi-sensor classification across four of the five public HAR benchmarks, and ranks second on the remaining benchmark. For single-sensor classification, it improves macro F1 by 1.3-8.5 pp on average over all the evaluated sensors. Further experiments confirm robustness to both sensor displacement and data scarcity. Github code available . https://github.com/FranciscoCalatrava/MultiView-Supervised-Contrastive-HAR.git.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bltekymalin_2025, title = {Infections and antibiotic use in early childhood have limited importance in developing manifest type 1 diabetes : The ABIS cohort study}, author = {Bélteky, Malin and Wahlberg, Jeanette and Ludvigsson, Johnny}, year = {2025}, journal = {Frontiers in Endocrinology}, volume = {16}, doi = {10.3389/fendo.2025.1529447}, url = {1943833}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {childhood environmental factors; gastroenteritis; infections; sex differences; type 1 diabetes}, abstract = {AIMS: To investigate the effect of early childhood infections and antibiotic use on the risk of type 1 diabetes in a general population cohort.RESEARCH DESIGN AND METHODS: The All Babies In Southeast Sweden (ABIS) cohort followed 16 428 children from birth. Questionnaires collected at 1 year (n=11 093), 3 years (n=8 890) and 5 years of age (n=7 445) included data on infections and antibiotic use and were validated against national registers. After a mean follow-up of 25 years, 168 individuals have been diagnosed with type 1 diabetes (1.0% of the original cohort, aged 1-24.5 years).RESULTS: There were few significant differences in type or frequency of early childhood infections or antibiotic use between cases with type 1 diabetes and the reference group (remaining individuals who did not develop type 1 diabetes) after adjusting for sex, heredity and socioeconomic status. A small number of type 1 diabetes children (4.8% compared to 0.8% of the reference group) reported six or more episodes of gastroenteritis in the 1-3-year age group, resulting in an adjusted odds ratio (aOR) of 8.21; 95% CI 2.70-25.01, p<0.001. Cases of type 1 diabetes with an increased genetic risk (n=91) reported fewer episodes of the common cold between 1 and 3 years of age compared to the reference group (aOR 0.27; 0.13-0.58, p<0.001). Individuals with type 1 diabetes without risk-associated HLA alleles (n=14) reported a higher frequency of pneumonia in the 1-3- and 3-5-year age group (aOR 26.08; 6.29-108.17, p<0.001 and aOR 35.63; 4.10-309.96, p=0.001 respectively), and had more viral and total infections registered in the National Patient Register from 0-5 years (aOR 5.72; 1.59-20.57, p=0.008 and aOR 18.71; 1.95-179.55, p=0.01).CONCLUSIONS: Childhood infections could increase the risk of developing type 1 diabetes in a small group of individuals without risk-associated HLA alleles, but this was not seen in the majority with HLA-risk. More research is required for this overlooked population, including screening and prevention trials. The association to frequent gastrointestinal infections in the first years of life needs to be reproduced in other studies to be confirmed.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_vingelienesnieguole_2025, title = {Infections, inflammation and neurodegenerative diseases from a life-course perspective}, author = {Vingeliene, Snieguole}, year = {2025}, url = {1934347}, language = {eng}, publisher = {Örebro University}, keywords = {atopic dermatitis; infections; sars-cov-2; parkinson’s disease; dementia; demyelinating diseases; multiple sclerosis; infectious mononucleosis}, abstract = {As disease risk for many conditions can start earlier in life, an essential aspect of these studies was to take a life-course approach using Swedish national register data to identify whether infectious or other inflammatory exposures are associated with a raised risk of subsequently diagnosed neurological diseases, and infectious mononucleosis whichis a risk factor for subsequent neurological sequelae.Study I investigated the risk of dementia at older ages associated with an atopic dermatitis diagnosis at around 18 years of age or at any point in life, using data from national Swedish registers. No association was found between atopic dermatitis and the risk of dementia among men or women.Study II examined a potentially causal association between hospital-treated infections and the subsequent risk of Parkinson’s disease (PD). Hospital-treated gastrointestinal and respiratory infections at ages 21-30, but not at ages 31-40 years, were associated withan elevated risk of PD.Study III examined whether a positive SARS-CoV-2 test only (less severe exposure) or hospital admission with COVID-19 (more severe exposure) could be a risk factor for demyelinating diseases of the central nervous system. Only the more severe exposure was associated with a raised risk of both multiple sclerosis (MS) and non-MS demyelinating diseases.Study IV explored whether SARS-CoV-2 infection is associated with a heightened risk of subsequent infectious mononucleosis due to Epstein-Barr virus (EBV-IM). National registers in Sweden were used for this research, covering the entire population betweenthe ages of 3 and 100. Both a positive SARS-CoV-2 test only and hospital admission with COVID-19 were associated with a raised risk of subsequent EBV-IM. This suggests that the immune perturbation caused by COVID-19 increases the risk of a more substantial immune response against EBV, resulting in IM.These studies indicate that infections occurring many years earlier in life may be aetiologically important in Parkinson’s disease and that the SARS-CoV-2 pandemic may be associated with conditions such as demyelinating diseases of the central nervous system and an increased risk of EBV-IM. Atopic dermatitis does not appear to be a risk factor for dementia.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kocharbharati_2025, title = {Inflammatory bowel disease patients are at increased risk for interstitial lung diseases}, author = {Kochar, Bharati and Sun, Jiangwei and Olén, Ola and Halfvarson, Jonas and Thuresson, Marcus and Hallowell, Robert and Ludvigsson, Jonas F.}, year = {2025}, journal = {American Journal of Gastroenterology}, doi = {10.14309/ajg.0000000000003699}, url = {1990396}, language = {eng}, publisher = {Blackwell Publishing}, keywords = {crohn’s disease; ulcerative colitis; pulmonology}, abstract = {OBJECTIVES: Pulmonary manifestations have been postulated in inflammatory bowel disease (IBD), but supporting data are scarce. We examined the risk of interstitial lung diseases (ILD) in IBD and its subtypes (ulcerative colitis, Crohn's disease, and IBD-unclassified).METHODS: We conducted a nationwide cohort study of individuals diagnosed with IBD in Sweden between 1969-2019 and followed until 2021. For each patient, we identified up to 5 matched general-population comparators. Through Cox regression, we examined adjusted hazard ratios (aHR) for ILD as defined by diagnostic codes in the National Patient Register. In a secondary analysis, patients with IBD were compared with their siblings free of IBD.RESULTS: We identified 85,705 patients with IBD and 412,677 general-population comparators. Over a median follow-up of 14 years, 438 (0.51%) patients with IBD and 1,253 (0.30%) comparators were diagnosed with ILD, corresponding to incidence rates of 34 and 20 per 100,000 person-years, respectively. Patients with IBD had a 48% greater relative risk of ILD (95% confidence interval (CI): 1.30-1.69). Stratified analyses showed increased risk in both ulcerative colitis and Crohn's disease. Patients with IBD also had a significantly greater risk of developing ILD compared with their siblings (aHR: 1.81, 95% CI: 1.43-2.27).CONCLUSION: In this nationwide cohort study of >85,000 patients with incident IBD, we found an increased risk of ILD.}, issn = {0002-9270} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mrildkarl_2025, title = {Inflammatory Bowel Disease, Periconceptional Disease Activity, and Risk of Major Congenital Anomalies : A Nationwide Cohort Study}, author = {Mårild, Karl and Söderling, Jonas and Stephansson, Olof and Axelrad, Jordan and Halfvarson, Jonas and Bröms, Gabriella and Marsal, Jan and Neovius, Martin and Pasternak, Björn and Olén, Ola and Ludvigsson, Jonas F.}, year = {2025}, journal = {American Journal of Gastroenterology}, volume = {120}, number = {10}, pages = {2350--2360}, doi = {10.14309/ajg.0000000000003306}, url = {1937962}, language = {eng}, publisher = {Blackwell Publishing}, keywords = {fertility; histology; prognosis}, abstract = {INTRODUCTION: It is uncertain whether the risk of major congenital anomalies (mCAs) is increased in children of women with inflammatory bowel disease (IBD).METHODS: We aimed to determine the risk of mCAs in a Swedish nationwide cohort of 13,131 singleton live births from 1997 to 2020 to women with IBD and 61,909 matched children to women without IBD from the general population. We additionally examined mCAs according to periconceptional histological inflammation (vs remission: 1,124 and 646 births, respectively) or clinically active IBD (vs quiescent: 3,380 and 6,603 births, respectively). Adjusted risk ratios (aRRs) for overall and organ-specific mCAs were estimated using generalized linear models. These models adjusted for maternal sociodemographics, comorbidities, body mass index, and smoking.RESULTS: There were 38.0 (n = 499) mCAs per 1,000 births to women with IBD vs 33.9 (n = 2,101) in matched comparators and a risk difference of 1 extra mCA per 246 births to women with IBD (aRR 1.11; 95% confidence interval [CI] 1.01-1.23). Risks of heart defects and mCAs of the urinary system partly drove estimates. The risk of mCAs was similar in children of women with ulcerative colitis and Crohn's disease. Periconceptional histological inflammation (vs remission) or clinically active (vs quiescent) IBD did not further influence the risk of mCA in the child (aRR 0.87 [95% CI 0.55-1.40] and aRR 1.04 [95% CI 0.85-1.27], respectively).DISCUSSION: Children of women with IBD had a heightened susceptibility to mCAs, although absolute and relative risks were lower than previously reported. IBD activity was not linked to mCA risks, but those analyses included relatively few events.}, issn = {0002-9270} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrnryter_2025, title = {Inflammatory response after stroke : A clinical observation study}, author = {Björn, Röyter and Andreasson, Nellie and Forgo, Bianka and Källman, Jan and Ström, Jakob O.}, year = {2025}, journal = {BMC Neurology}, volume = {25}, number = {1}, doi = {10.1186/s12883-025-04244-y}, url = {1967326}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {stroke; infection; wbc; crp; temperature}, abstract = {Background: Body temperature and peripheral blood inflammatory markers are often elevated in acute stroke. Whether the increase in inflammatory markers is caused by the stroke itself or is attributable to a complication, is incompletely understood. This uncertainty may hamper the diagnosis and treatment of infections. We aimed to describe the dynamics of inflammatory parameters in a cohort of stroke patients free from complications.Methods: Acute stroke patients were prospectively included within 48 h of symptom onset and monitored through daily questions of symptoms and clinical examinations to detect complications. Inflammatory parameters in blood and body temperature were measured daily for up to ten days and the 97.5th percentile calculated. Values were compared with paired t-test to measurements at a 90-day follow up.Results: 70 stroke patients were included. 51 of them were considered complication-free and sampled for a total of 282 days. Body temperature, CRP and WBC were all significantly elevated the first days after stroke, compared to 90-days post stroke. Mean body temperature was highest at 24-48h at 37.1 degrees C, mean WBC was highest at 0-24h at 8.1 x 10<^>9/L, compared to 36.7 degrees C and 6.0 x 10<^>9/L at the 90-day follow-up (p-values < 0.01). Median CRP peaked at 7.0 mg/L 120-144 h after stroke, compared to 0.9 mg/L at follow-up (p-value < 0.01).Conclusions: Acute stroke may cause mildly elevated levels of CRP, WBC and body temperature. Except for WBC during the first 24h, higher levels (such as CRP > 50mg/L, WBC > 11 x 10<^>9/L or body temp > 38 degrees C) are very uncommon (< 2.5%) and are likely to reflect a complication.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rasmussenbengt_2025_1, title = {Influence of Cytogenetics on the Outcome of Patients With High-Risk Myelodysplastic Syndrome Including Deletion 5q Treated With Azacitidine With or Without Lenalidomide}, author = {Rasmussen, Bengt and Nilsson, Lars and Tobiasson, Magnus and Jädersten, Martin and Garelius, Hege and Dybedal, Ingunn and Grønbaek, Kirsten and Ejerblad, Elisabeth and Lorenz, Fryderyk and Flogegård, Max and Marcher, Claus Werenberg and Cavalier, Lucia and Ebeling, Freja and Olsnes, Astrid Marta and Nørgaard, Jan Maxwell and Saft, Leonie and Möllgård, Lars and Hellström-Lindberg, Eva and Schlegelberger, Brigitte and Göhring, Gudrun}, year = {2025}, journal = {Genes, Chromosomes and Cancer}, volume = {64}, number = {2}, doi = {10.1002/gcc.70029}, url = {1936024}, language = {eng}, publisher = {Wiley-Liss Inc.}, keywords = {tp53; azacitidine; deletion 5q; high‐risk myelodysplastic syndrome; lenalidomide; outcome}, abstract = {In myelodysplastic syndromes (MDS), cytogenetic characteristics of the malignant bone marrow cells influence the clinical course. The aim of this study was to evaluate whether cytogenetics is useful to predict outcome and response in patients with del(5q) under azacitidine (AZA) ± lenalidomide (LEN) therapy. We therefore performed comprehensive cytogenetic analyses in MDS patients with del(5q) treated within the randomized phase II trial NMDSG10B. Seventy-two patients were enrolled in the study and 46 patients (64%) had sufficient cytogenetics at inclusion and response evaluation. Karyotyping was significantly more sensitive during follow-up to detect del(5q) compared to FISH, 34 patients (97%) versus 27 patients (77%) (p = 0.027). The overall response rate (ORR) did not differ between the 11 patients with < 3 aberrations (median 1 aberration) and the 59 patients with ≥ 3 aberrations (median 7 aberrations, range 3-16), while ≥ 3 aberrations were associated with shorter overall survival (OS), 9.9 months versus 25.2 months (p = 0.004). OS was significantly shorter in patients with unbalanced translocation of 5q than patients with del (5)(q14q34), 8.4 months versus 21.1 months (p = 0.004). Both complex karyotype and multi-hit TP53 alterations were more frequent in patients with unbalanced translocations of 5q versus del (5)(q14q34), 98% and 88% versus 67% and 47% (each p = < 0.001). Most patients with cytogenetic progression had multi-hit TP53 alterations at inclusion. Cytogenetic progression occurred at a similar frequency in the AZA arm and in the AZA + LEN arm. In summary, this study in homogenously treated MDS patients with different abnormalities of 5q demonstrates the influence of cytogenetics on treatment results. Trial Registration: EudraCT number: 2011-001639-21; ClinicalTrials.gov identifier: NCT01556477.}, issn = {1045-2257} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_lfstrandmagnus_2025, title = {Information and process modelling for mining enterprises}, author = {Löfstrand, Magnus and Eklund, Patrik}, year = {2025}, url = {2013663}, language = {eng} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_vanbellejono_2025_2, title = {Ingmar Bergman Out of Focus : Film Cultures and International Reception}, author = {Van Belle, Jono and Ramos Arenas, Fernando and Peirano Olate, María Paz}, year = {2025}, doi = {10.3167/9781805398790}, url = {1942685}, language = {eng}, publisher = {Berghahn Books}, abstract = {Director Ingmar Bergman occupies a central place in the history of modern cinema. Credited with igniting a cinematic revolution, his ability to produce work which resonated with audiences globally has brought scholarly attention to the impact of Bergman’s Swedish background on his oeuvre. Ingmar Bergman Out of Focus revises this question of Bergman’s “familiarity” to produce a more expansive understanding of Bergman’s cultural heritage. Considering the impact of Bergman’s films on film festival organizers, critics, academics, and audiences all over the world, this volume illuminates how Bergman’s film aesthetics simultaneously shaped modern culture and were themselves reshaped by the debates and concerns that preoccupied his viewers.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mclaughlinchristopher_2025, title = {Initial Adhesive Small Bowel Obstruction Management Pathway Drives Infectious Complication Occurrence}, author = {McLaughlin, Christopher and Kaplan, Lewis J. and Martinez-Casas, Isidro and Mohseni, Shahin and Cimino, Matteo and Kurihara, Hayato and Lee, Matthew J. and Bass, Gary Alan}, year = {2025}, journal = {Surgical Infections}, doi = {10.1177/10962964251380382}, url = {1998851}, language = {eng}, publisher = {Mary Ann Liebert}, keywords = {non-operative management; operation; outcomes; small bowel obstruction; surgical site infection}, abstract = {Introduction: The Bologna guideline outlines three small bowel obstruction (SBO) management pathways. It remains unclear how pathway selection influences post-operative infections.Methods: A multi-national, prospective, observational, audit of SBO management (November 1, 2023-May 31, 2024) captured demographics, care, and outcomes. Patients were grouped by pathway (successful non-operative management [NOM], NOM followed by surgery [NOM-T], direct to surgery [DTS]). Intergroup comparisons by chi-square or Fisher exact test, significance for p < 0.05.Results: A total of 1,737 patients were assessed across 21 countries (850 NOM, 379 NOM-T, 508 DTS). Operative cohorts demonstrated similar age (NOM-T 65.2 ± 17.3 vs. DTS 65.5 ± 18.4 y; p = 0.834) and gender (NOM-T 53.6% vs. DTS, 52% female; p = 0.688). Comorbidities were more frequent in patients undergoing NOM-T (77.8%) versus DTS (69.7%; p < 0.001). DTS demonstrated more intestinal ischemia (NOM-T 22.8% vs. DTS 33%; p = 0.002). Time to OR was longer in NOM-T (43.8 ± 30.6 vs. DTS 12.4 ± 15.2 h; p < 0.001). Hospital length of stay (LOS) (NOM-T 12.4 ± 15.2 vs. DTS 7.7 ± 8.0 d; p < 0.001) and LOS (NOM-T 10.1 ± 10.4 vs. DTS 6.6 ± 9.1 d; p < 0.001) were longer in NOM-T. Superficial wound dehiscence (3.9%) and fascial dehiscence (2.6%) were uncommon. Overall surgical site infection (SSI) incidence was similar (NOM-T 8.7% vs. DTS 7.7%; p = 0.578). Deep SSI overall frequency was low (3.9%) but increased in NOM-T (5.5%) versus DTS (2.8%, p = 0.035). Conclusions: An NOM trial before operation for adhesive SBO seems to increase deep SSI risk and likely reflects time to OR as well as hospital and surgeon factors-elements that merit specific evaluation.}, issn = {1096-2964} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_10, title = {Inledning : I krisernas tid - Kapitalism, nyliberalism och den samtida marxistiska teorin}, author = {Johansson Wilén, Evelina and Schack, Lotte and Wilén, Carl and Örestig Kling, Johan}, year = {2025}, url = {2000849}, language = {swe}, publisher = {Daidalos} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_dahlizabelaa_2025_3, title = {Inledning : Vad är Förintelsen?}, author = {Dahl, Izabela A. and Kvist Geverts, Karin}, year = {2025}, pages = {8--20}, url = {1953984}, language = {swe}, publisher = {Natur och kultur}, keywords = {förintelsen; sverige; lärobok} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_deutschmannmats_2025_3, title = {Innovation for Inclusion : True inclusion requires rethinking who education is for, how it is delivered, and whose knowledge counts}, author = {Deutschmann, Mats and Pejakovic, Christine}, year = {2025}, journal = {Seychelles Research Journal}, volume = {7}, number = {special issue}, pages = {1--6}, url = {1998135}, language = {eng}, publisher = {University of Seychelles}, keywords = {innovation; inclusive education; multilingual classroom; sub-saharan africa}, abstract = {Special issue Innnovation for Inclusion overview.}, file = {https://oru.diva-portal.org/smash/get/diva2:1998135/FULLTEXT01.pdf} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_harveyfrida_2025, title = {Inquiry-based Collaborations for Mathematics Teaching Improvement : Reframing Division of Labor, Rules, and Mediating Artifacts}, author = {Harvey, Frida}, year = {2025}, url = {2007686}, language = {eng}, publisher = {Örebro University}, keywords = {inquiry; collaborations; mediating artifacts; boundary objects; cultural historical activity theory; mathematics education}, abstract = {This dissertation examines professionals’ Inquiry-based Collaborations for Mathematics Teaching Improvement (ICMTI) through a Cultural Historical Activity Theory (CHAT) framework. While teacher collaboration has a long history, recent research highlights the importance of systematic, inquiry-driven practices that foster critical reflection and the use of data to improve teaching. However, establishing such collaborations poses challenges for professionals, both in terms of organization and the methods and artifacts used for inquiry.The study aims to advance understanding of ICMTI and its processes by investigating how such collaborations may be organized, the challenges encountered, how these challenges may be navigated, as well as the artifacts that mediate collaborative processes and their consequences.To achieve this, the dissertation is grounded in three studies: a systematic literature review, an interview study, and an observational case study, all of which are analyzed using different CHAT-based frameworks. The dissertation deepens the understanding of ICMTI as a complex process, highlighting and nuancing the importance of reflecting on the division of labor, prevailing norms, and the use of artifacts, both in planning and throughout the implementation of ICMTI.This dissertation offers practical insights for designing and implementing future ICMTI and contributes theoretically to the concepts of ICMTI, multi-mediating, and boundary-negotiating artifacts.}, file = {https://oru.diva-portal.org/smash/get/diva2:2007686/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_laijianwen_2025_1, title = {Insight into the performance of VOx-WOx/TiO2 catalysts modified by various cerium precursors : A combined study on synergistic NOx and chlorobenzene removal}, author = {Lai, Jianwen and Qi, Hongbo and Ma, Yunfeng and Lin, Xiaoqing and Wang, Xiaoying and Han, Zhongkang and Fiedler, Heidelore and Li, Xiaodong}, year = {2025}, journal = {Journal of Colloid and Interface Science}, volume = {687}, pages = {143--157}, doi = {10.1016/j.jcis.2025.02.060}, url = {1937977}, language = {eng}, publisher = {Elsevier}, keywords = {acidity regulation; cvoc; cerium modification; denitrification; reaction mechanism}, abstract = {Cerium is widely used as a modifier to enhance the catalytic performance of the selective catalytic reduction (SCR) catalysts due to its exceptional low-temperature properties. However, the effects of different cerium precursors on catalytic performance remains unclear. In this study, VOx-WOx/TiO2 catalysts are modified using Ce(NO3)3·6H2O (cata-N), CeO2 (cata-O), and Ce(OH)4 (cata-OH), and their synergistic removal of NOx and chlorobenzene (CB), as well as their resistance to water and sulfur poisoning, were systematically investigated. Among the tested catalysts, cata-N demonstrated superior CB (45.0-93.3 %) and NOx (31.9-90.37 %) removal efficiencies under synergistic conditions, along with excellent water resistance (T90 = 193 °C with 5 % H2O). In contrast, cata-OH exhibited the highest sulfur resistance, maintaining a denitrification efficiency of 20 % after 10 h of sulfur exposure, compared to 9 % for cata-N and 8 % for cata-O. Characterization revealed that Ce(NO3) 3·6H2O improved cerium dispersion, leading to enhanced the redox properties and acidity (especially Brønsted acid sites (BAS)) in cata-N. Density functional theory (DFT) calculations and In-situ Diffuse Reflectance Infrared Fourier Transform Spectroscopy (In-situ DRIFTS) results revealed that the well-dispersed cerium atoms contributed additional BAS in the form of Ce-OH, while also forming Ti-O-Ce bonds. These Ti-O-Ce bonds facilitated the formation of Ti-OH on the TiO2 surface. Ti-OH significantly enhanced the adsorption of NH3 and CB, thereby promoting both the NH3-SCR and CB oxidation processes. This study offers new insights into the role of cerium precursors and provides a practical strategy for tuning BAS of catalysts in multiple pollutants removal.}, issn = {0021-9797} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vtinenlaura_2025, title = {Instruments for Short-Term (24 h) Violence Risk Assessment and Strategies for Managing Violence Risk Among Adolescents With Risk for Violent Behaviour : A Systematic Review}, author = {Väätäinen, Laura and Björkqvist, Maiju and Li, Yan and Pelto-Piri, Veikko and Ferreira, António and Lantta, Tella}, year = {2025}, journal = {International Journal of Mental Health Nursing}, volume = {34}, number = {4}, doi = {10.1111/inm.70110}, url = {1990160}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {adolescent; mental health; outcomes; risk assessment; risk management; violence}, abstract = {Short-term (24 h) violence risk assessment and management can reduce violence in institutional settings, yet they remain understudied in adolescent populations. This systematic review aimed to identify instruments used for short-term violence risk assessment and strategies for managing violence risk among adolescents in institutional settings, as well as to evaluate related outcomes. PRISMA was used as an evidence-based minimum set of items for reporting systematic reviews. The literature search (March 2024 and March 2025) was conducted in PubMed, PsycINFO, Web of Science, CINAHL, The Cochrane Library and Scopus, and references from selected studies were reviewed. Data extraction and analysis were performed in Covidence. Nine studies met inclusion criteria describing six assessment instruments: DASA, DASA-YV, V-RISK-Y, Kennedy Axis V, Pedi-BEWS and BVC. No studies regarding strategies for short-term violence risk management were identified. DASA-YV, BVC and V-RISK-Y predicted violence among adolescents within 24 h (AUC = 0.70-0.95); DASA predicted violence moderately (AUC = 0.50-0.69). Pedi-BEWS (ICC = 0.83) and Kennedy Axis V (ICC = 0.79) demonstrated similar inter-rater reliability. Due to the lack of studies, firm conclusions on the best instrument for clinical practice in institutional settings remained elusive. Further research is necessary to ascertain if youth-specific instruments (e.g., DASA-YV, V-RISK-Y) predict violence more effectively than non-age-specific instruments (e.g., DASA). The lack of youth engagement in violence risk assessment stands out clearly. Scoring was done by the staff, mostly by nurses. Future studies should involve adolescents in the scoring or evaluation of assessment and management. There is a need for evidence-based recommendations for youth engagement.}, issn = {1445-8330} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_volgstenulrik_2025_2, title = {Instudering av Beethovens Sonat för piano och violin op. 30.2 : Gadamerskt spel, från dialog till affektintoning}, author = {Volgsten, Ulrik and Johnson, Lena}, year = {2025}, url = {2012589}, language = {swe}, keywords = {gadamer; instudering; tolkning; förståelse}, abstract = { Vad innebär det att gestalta ett stycke musik? I den här presentationen försöker vi besvara frågan – åtminstone vad det kaninnebära att gestalta ett stycke musik – mot bakgrund av Hans-Georg Gadamers fenomenologiska hermeneutik. Framför allt är det Gadamers idé om spel som en utgångspunkt för tolkning och förståelse som hjälper oss att åskådliggöra ett antal skeenden under den specifika gestaltningsprocess vi valt att studera. Dessutom visar sig musiken belysa och konkretisera Gadamers spelmetafor på nya sätt. Utgångspunkten för undersökningen är de loggboksanteckningar som fördes av en av oss vid en tidigare instudering av Ludwig van Beethovens Sonat för piano och violin i c-moll op. 30 nr 2. Instuderingen skedde vid tolv repetitionstillfällen, genomförda i tre skilda omgångar, under en tidsperiod av sex månader, varav de flesta tillfällena varade i 2 till 3 timmar. Det sista tillfället innefattade dessutom en inspelning av sonaten (vilket hade en särskild påverkan på gestaltningen). Medan Gadamers begrepp visade sig särskilt belysande i de inledande faserna av gestaltningsarbetet, så fann vi hans begrepp om horisontsammansmältning otillräckligt för att beskriva de tillfällen av upplevd samstämmighet som succesivt uppstod mellan musiker och verk ju längre gestaltningsarbetet fortskred. Som en substantiell vidareutveckling av Gadamers idéer föreslår vi därför – på grundval av de erfarenheter som det musikaliska gestaltningsarbetet inneburit och svarande på vår inledande frågeställning – det Daniel Stern beskrivit som vitalitetsaffekt och affektintoning. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bergemalmdaniel_2025_2, title = {Insulin sensitivity in moderately severe to acute severe ulcerative colitis}, author = {Bergemalm, Daniel and Baban, Bayar and Ljungqvist, Olle and Halfvarson, Jonas}, year = {2025}, journal = {Scandinavian Journal of Gastroenterology}, volume = {60}, number = {3}, pages = {243--247}, doi = {10.1080/00365521.2025.2459870}, url = {1933282}, language = {eng}, publisher = {Taylor & Francis}, keywords = {ulcerative colitis; hyperinsulinemic euglycemic clamp; insulin resistance}, abstract = {BACKGROUND: Patients hospitalized with moderately severe or acute severe ulcerative colitis (UC) may experience metabolic disturbances, including alterations in insulin resistance due to inflammation and the administration of glucocorticoids (GCs). This pilot study aimed to evaluate insulin sensitivity in patients hospitalized for moderately severe to severe UC.METHOD: Patients hospitalized for moderately-severely active UC at Örebro University Hospital, Sweden, were eligible for inclusion. Quantification of insulin sensitivity was performed using the hyperinsulinemic euglycemic clamp (HEC) methodology. Assessment of insulin sensitivity was performed during both the index flare and while patients were in steroid-free clinical, biochemical and endoscopic remission during follow-up. Additionally, healthy controls were evaluated using HEC for comparison.RESULTS: Five patients with moderately-severely active UC, treated with intravenous GCs for ≥2 days, were included and underwent HEC assessment. During the index flare, four patients received second-line treatment with infliximab due to non-response to GC, and one patient was subsequently referred for acute subtotal colectomy. At inclusion, all five patients exhibited significantly reduced insulin sensitivity, and levels appeared similar regardless of the outcome of the index flare. At remission during follow-up, the insulin sensitivity was restored to levels comparable to healthy controls (n = 5).CONCLUSION: The study demonstrates that patients with moderately severe to severe UC experience significant insulin resistance, irrespective of the outcome of the flare. The reduced insulin sensitivity is likely driven by a combination of active inflammation and GC treatment, as insulin sensitivity returned to normal levels when patients achieved remission during follow-up.}, issn = {0036-5521} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_larssonmia_2025, title = {Intangible cultural heritage}, author = {Larsson, Mia and Öberg, Christina and Scander, Henrik}, year = {2025}, pages = {201--204}, url = {1992065}, language = {eng}, publisher = {Edward Elgar Publishing} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johnstoneleanne_2025_1, title = {Integrating sustainability - an institutional perspective on change}, author = {Johnstone, Leanne and Skoog, Matti}, year = {2025}, journal = {Journal of Accouting & Organizational Change}, volume = {21}, number = {7}, pages = {386--415}, doi = {10.1108/JAOC-03-2025-0061}, url = {2007960}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {sustainability integration; management accounting change; institutional framework; sustainability control systems}, abstract = {Purpose: This study aims to better understand the role of institutions for sustainability integration within organisations and the broader debate on whether the integration of sustainability with existing systems of management accounting and control should be pursued.Design/methodology/approach: A longitudinal case study (2017-2023) of a large European logistics company, based on 23 interviews, site visits and other secondary data sources, was conducted. An institutional framework was used to frame two analytical levels of integration (i.e. strategic and tactical/operational) and institutions (i.e. external and internal) over time.Findings: There is resistance to integration along organisational, technical and cognitive dimensions. Sustainability roles and functions remain decoupled from financial ones, and cognitive integration remains limited to tactical levels and sustainability personnel. Meanwhile, the rules of existing accounting systems have not changed, while the informal routines associated with them have, in response to broader institutional demands, particularly for environmental information.Research limitations/implications: Beyond contributing to the sustainability integration concept, the study adds to institutional research on management accounting change by suggesting that changes in system use, rather than system design, are important for sustainability issues.Practical implications: Managers in large organisations should focus on the technical and cognitive aspects of integration to develop common calculation infrastructures and shared mindsets around sustainability. Meanwhile, specialised personnel still appear necessary to coordinate and control sustainability efforts.Originality/value: The study provides a nuanced understanding of the integration concept and the role of institutions in the integration process - particularly the degree of integration across different levels and dimensions, as well as the various, parallel integration pathways.}, issn = {1832-5912} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rombokarl_2025, title = {Integration of Basic Science into Virtual Patient Cases to Enhance Clinical Reasoning Skills}, author = {Rombo, Karl and Borg, Alexander and Georg, Carina and Parodis, Ioannis}, year = {2025}, journal = {Information}, volume = {16}, number = {11}, doi = {10.3390/info16110950}, url = {2019948}, language = {eng}, publisher = {MDPI}, keywords = {virtual patients; clinical reasoning; basic science}, abstract = {Objective: To explore medical students' perceptions towards the integration of basic science into virtual patient (VP) cases and to evaluate the impact on self-perceived clinical reasoning (CR) ability.Methods: We conducted a qualitative and explorative study involving 14 medical students during their clinical placement within rheumatology. Basic science elements were integrated into five VP scenarios using the virtual interactive case simulator. Students' perceptions were explored through the analysis of semi-structured interviews with seven students, followed by Malterud's systematic text condensation.Results: The analysis yielded five themes: (i) appreciation of basic science knowledge, (ii) ambiguity towards basic science as an obstacle for integration, (iii) the effect of integration on self-perceived clinical reasoning, (iv) engaging design of the basic science integration, and (v) low knowledge of clinical reasoning concepts. Despite positive perceptions, students demonstrated low motivation for independent engagement in practice. The students who completed the intervention reported enhanced self-perceived CR abilities, as evidenced by more comprehensive thinking processes.Conclusions: Basic science integration into VP cases was positively perceived and appeared to enhance self-perceived CR abilities. However, students' reluctance to independently engage posed implementation challenges. Early introduction of CR learning objectives and CR as a conceptual framework may improve motivation and provide coherence for the integration of basic science in the clinical components of medical education.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_orzikhyurii_2025_1, title = {Integration of Legaltech and AI In the Ukrainian Notariat : Ensuring Sustainable Turnover}, author = {Orzikh, Yurii}, year = {2025}, pages = {241--251}, url = {1976669}, language = {eng}, publisher = {SciFormat Publishing}, keywords = {electronic notariat; remote notarisation; non-contentious justice; legaltech and ai in notary; sustainable turnover.}, abstract = {The chapter examines the process of integrating LegalTech and AI into the activities of the Ukrainian notariat in the context of digital transformation, war and post-war reconstruction. The author proves that the integration of LegalTech and AI into the activities of the Ukrainian notariat does not pose a threat to the traditional role of the notary, but, on the contrary, strengthens its function as a guarantor of legal certainty, authenticity and non-contentious justice. Based on a comparative analysis of the experience of Brazil, Mexico, Canada and Estonia, the author identifies models of electronic notaries that may be relevant to Ukrainian realities. The author also examines legislative initiatives in Ukraine, in particular the draft Law of Ukraine "On Amendments to Certain Legislative Acts of Ukraine on Improving the Regulation of Notarial Activities". The author emphasises the importance of ensuring cybersecurity, preserving notarial secrecy, regulatory definition of the boundaries of responsibility of notaries and technology providers, and the need to improve the digital literacy of notaries. The article emphasises that the Ukrainian experience is unique, since the digitalisation of the notariat sphere is taking place in the context of war, which requires a cautious and adaptive approach to the introduction of innovations to ensure sustainable economic circulation.}, file = {https://oru.diva-portal.org/smash/get/diva2:1976669/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_patilrajeshv_2025, title = {Integration of Vision-Based Inspection and Edge Computing for High Throughput Lithium-Ion Battery Production}, author = {Patil, Rajesh V. and Löfstrand, Magnus}, year = {2025}, doi = {10.1109/ICCMA67641.2025.11369567}, url = {2005254}, language = {eng}, publisher = {IEEE}, keywords = {automated inspection; lithium-ion battery; machine vision; digital traceability; robotic handling}, abstract = {Automated inspection in lithium-ion battery manufacturing has emerged as a significant enabler of quality assurance, process optimization, and operational efficiency. Defect detection at several stages from electrode manufacturing to cell packaging has a direct impact on battery safety, performance, and durability. Traditional machine vision approaches were early solutions for detecting electrode flaws, but recent improvements in deep learning, hybrid image processing, and AI assisted inspection have considerably improved accuracy, resilience, and real-time capabilities. This study proposes a comprehensive automated inspection framework that incorporates 3D structured-light profiling, high-speed 2D line-scan imaging, and edge-computing-enabled analytics throughout the production process. The system controls coating uniformity, calendering integrity, geometric precision, electrode alignment, and weld quality, all while ensuring comprehensive digital traceability via MES integration. Vision-guided robotic handling improves assembly accuracy, throughput, and process reliability. By merging multidimensional sensing modalities with AI-driven analysis, the proposed framework assures high-throughput, defect-free battery manufacture while lowering waste, boosting sustainability, and promoting Industry 5.0 digitalization.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stenbergerik_2025, title = {Intentional weight reduction before surgery : A systematic review}, author = {Stenberg, Erik and Laurenius, Anna and Thorell, Anders}, year = {2025}, journal = {Clinical Nutrition}, volume = {45}, pages = {156--164}, doi = {10.1016/j.clnu.2025.01.008}, url = {1929684}, language = {eng}, publisher = {Churchill Livingstone}, keywords = {meta-analysis; obesity; operation time; postoperative complication; systematic review; weight loss}, abstract = {INTRODUCTION: Obesity may increase complexity of surgical procedures and increase the risk of perioperative complications. Weight reduction by the use of low energy diet (LED, ≤1200 kcal/day) or very low energy diet (VLED, ≤800 kcal/day) can reduce postoperative complications after bariatric surgery, but for most other types of surgery the evidence for its use remains uncertain. The aim of this systematic review was therefore to evaluate the scientific evidence in general for this routine.METHODS: The Medline, Embase, Web of Science and Cochrane databases were searched up until November 20, 2024 using the Cochrane risk of bias assessment tool for observational studies and the NIH quality assessment of controlled intervention studies for randomized trials. Operation time, surgeon's perceived difficulty, intraoperative complications, postoperative complications and relevant efficacy measures for specific procedures were considered as endpoints. A random-effects model was used to pool effect sizes for the main analyses.RESULTS: A total of 7053 studies were identified. After screening by title and abstract, followed by full text, 18 studies (9 RCTs and 9 observational studies) remained for the analyses including 854 patients who received the intervention and 979 controls. Preoperative LED/VLED resulted in an overall shorter operation time (standard mean difference 0.36, 95 % CI 0.14-0.59, p = 0.002), and reduced risk of postoperative complications after bariatric surgery, cholecystectomy, colorectal surgery and hernia repair (pooled RR 0.63, 95%CI 0.51-0.79, p < 0.001). Heterogeneity between studies was high for operation time but very low for complications. No difference was seen for intraoperative complications, while the data did not allow further analyses on perceived difficulty of surgery or efficacy outcomes.CONCLUSION: The results support the use of LED/VLED for short-term preoperative weight reduction in patients with obesity planned for bariatric surgery and for those undergoing cholecystectomy, colorectal surgery and hernia repair. Further studies including a comparable control group are needed to evaluate its routine use for other surgical procedures.REGISTRATION: The protocol of this study was preregistered at the International Prospective Register of Systematic Reviews, PROSPERO.}, issn = {0261-5614} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_sygkounasalkis_2025, title = {Interactive Double Deep Q-network : Integrating Human Interventions and Evaluative Predictions in Reinforcement Learning of Autonomous Driving}, author = {Sygkounas, Alkis and Athanasiadis, Ioannis and Persson, Andreas and Felsberg, Michael and Loutfi, Amy}, year = {2025}, pages = {2325--2332}, doi = {10.1109/IV64158.2025.11097638}, url = {2002843}, language = {eng}, publisher = {IEEE}, abstract = {Integrating human expertise with machine learning is crucial for applications demanding high accuracy and safety, such as autonomous driving. This study introduces Interactive Double Deep Q-network (iDDQN), a Human-in-the-Loop (HITL) approach that enhances Reinforcement Learning (RL) by merging human insights directly into the RL training process, improving model performance. Our proposed iDDQN method modifies the Q-value update equation to integrate human and agent actions, establishing a collaborative approach for policy development. Additionally, we present an offline evaluative framework that simulates the agent's trajectory as if no human intervention to assess the effectiveness of human interventions. Empirical results in simulated autonomous driving scenarios demonstrate that iDDQN outperforms established approaches, including Behavioral Cloning (BC), HG-DAgger, Deep Q-Learning from Demonstrations (DQfD), and vanilla DRL in leveraging human expertise for improving performance and adaptability.} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_seymourkate_2025, title = {Interconnecting the Violences of Men : Continuities and Intersections in Research, Policy and Activism}, author = {Seymour, Kate and Pease, Bob and Strid, Sofia and Hearn, Jeff}, year = {2025}, doi = {10.4324/9781003415077}, url = {1919314}, language = {eng}, publisher = {Routledge}, keywords = {violence; violences; men; masculinities; policy; activism; research; interconnections}, abstract = {This book aims to expand and enrich understandings of violences by focusing on gendered continuities, interconnections and intersections across multiple forms and manifestations of men’s violence. In actively countering, both, the compartmentalisation of studies of violence by ‘type’ and form, and the tendency to conceptualise violence narrowly, it aims to flesh out – not delimit – understandings of violence.Bringing together cross-disciplinary, indeed transdisciplinary, perspectives, this book addresses how –what are often seen as – specific and separate violences connect closely and intricately with wider understandings of violence, how there are gendered continuities between violences and how gendered violences take many forms and manifestations and are themselves intersectional. Grounded by the recognition that violence is, itself, a form of inequality, the contributors to this volume traverse the intersectional complexities across, both, experiences of violent inequality, and what is seen to ‘count’ as violence.The international scope of this book will be of interest to students and academics across many fields, including sociology, criminology, psychology, social work, politics, gender studies, child and youth studies, military and peace studies, environmental studies and colonial studies, as well as practitioners, activists and policymakers engaged in violence prevention.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_hearnjeff_2025_4, title = {Interconnecting violences for research, policy and activism : Concluding reflections}, author = {Hearn, Jeff and Strid, Sofia and Pease, Bob and Seymour, Kate}, year = {2025}, pages = {265--274}, url = {1919827}, language = {eng}, publisher = {Routledge}, keywords = {violence; gender; men; masculinities; interconnections}, abstract = {This chapter brings together multidisciplinary and intersectional perspectives on the interconnections  and continuities across multiple forms and manifestations of violence. Grounded in an understanding of violence as gendered and “itself a form of social inequality, an unequal and unequalizing social structural division and relation of its own” (Hearn, 2012, p. 164), the contributors to this volume have sought to engage with violences as enactments of domination. The chapter reviews how this book has sought to focus on three, closely related themes: first, violences in the plural; second, men, masculinities, men’s violences and violent masculinities; and third, their intersectional gendered relations and interconnections. In the light of that, three issues arew reflected on: the kinds of violences examined by our contributors; the main interconnections stressed by them in their analyses; and the nature of these interconnections recognized; before comments and suggestions for future work for research, policy and activism.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisioannis_2025_3, title = {INTERFERON AND B LYMPHOCYTE DYSREGULATION PATTERNS DETERMINE DISTINCT LUPUS NEPHRITIS SUBGROUPS WITH DIFFERENTIAL ANTICIPATED RESPONSE TO TARGETED THERAPIES}, author = {Parodis, Ioannis and Lindblom, J. and Toro-Dominguez, D. and Beretta, L. and Borghi, M. O. and Castillo, J. and Carnero-Montoro, E. and Enman, Y. and Mohan, C. and Alarcon-Riquelme, M. and Barturen, G. and Nikolopoulos, D.}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {83}, number = {Suppl. 1}, pages = {264--265}, doi = {10.1136/annrheumdis-2024-eular.4304}, url = {1989041}, language = {eng}, publisher = {Elsevier}, keywords = {'-omics; targeted synthetic drugs; biomarkers; cytokines and chemokines}, abstract = {Background: The aim of this study was to investigate the LN transcriptome in depth to gain insight into underlying mechanisms and identify potential drug targets for LN.Objectives: The aim of this study was to investigate the LN transcriptome in depth to gain insight into underlying mechanisms and identify potential drug targets for LN.Methods: We analysed differentially expressed genes (DEGs) in peripheral blood from active LN (n=41) and active non-renal lupus (n=62) patients versus healthy controls (n=497) from the European PRECISESADS project (NTC02890121) and dysregulated gene modules in a discovery (n=26) and a replication (n=15) set of active LN cases. Replicated gene modules qualified for correlation analyses with serological markers, and regulatory network and druggability analysis.Results: We found 9578 DEGs in active LN vs HC and 8144 DEGs in active non-renal SLE vs HC. Active LN and active non-renal lupus patients shared 6653 DEGs, while 2925 DEGs were exclusively dysregulated in the LN group, denoting an LN-specific signature (Figure 1A). Among the latter, 818 DEGs displayed a |log2 fold change (FC)| >0.58 (Figure 1A). The LN signature comprised DEGs associated with neutrophil degranulation, transcription regulation by TP53, and DNA damage response GO pathways (Figure 1B). Unsupervised co-expression network analysis revealed 20 dysregulated gene modules; seven showed prominent dysregulation in three distinct subgroups of LN patients (Figure 2A). These subgroups were classified based on the “interferon” (IFN) gene module upregulation into low, intermediate, and high IFN subgroups and showed differential dysregulation of the “B cell” and “plasma cells/immunoglobulins” modules. Drugs annotated to the IFN network included CC-motif chemokine receptor 1 (CCR1) inhibitors, programmed death-ligand 1 (PD-L1) inhibitors, and irinotecan, while the anti-CD38 daratumumab and proteasome inhibitor bortezomib showed potential for counteracting the transcriptomic signature associated with the “plasma cells/immunoglobulins” module. In silico analysis demonstrated that the low-IFN subgroup may benefit from calcineurin inhibitors while the intermediate-IFN subgroup may benefit from B cell targeted therapies (Figure 2B). High-IFN patients exhibited greater anticipated response to anifrolumab while the intermediate-IFN and high-IFN subgroups displayed greater anticipated response to daratumumab.Conclusion: Interferon upregulation and B and plasma cell gene dysregulation patterns revealed three distinct LN patient subgroups, each demonstrating unique anticipated responses to existing or novel targeted therapies, paving the way for informed and tailored treatment strategies in LN. Of particular interest were irinotecan, CCR1 inhibitors, and PD-L1 antagonists interfering with IFN-mediated pathways, and bortezomib and daratumumab for their interference with plasma cells. While further studies are warranted to investigate the potential of these drugs, our findings contribute to a conceptual framework of precision medicine in the management of LN.}, issn = {0003-4967} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssonelin_2025_2, title = {International Classification of Functioning, Disability and Health as a Foundation for Instrument Development : Translation and Field Testing of the Swedish Version of the Hearing and Functioning in Everyday Life Questionnaire}, author = {Karlsson, Elin and Granberg, Sarah and Mäki-Torkko, Elina and Widén, Stephen and Gustafsson, Johanna}, year = {2025}, journal = {Journal of Speech, Language and Hearing Research}, volume = {68}, number = {7}, pages = {3369--3384}, doi = {10.1044/2025_JSLHR-24-00620}, url = {1969934}, language = {eng}, publisher = {American Speech-Language-Hearing Association}, abstract = {PURPOSE: The aim of the current study was to translate the English original version of the Hearing and Functioning in Everyday Life Questionnaire (HFEQ) to Swedish, evaluate the translation in terms of comprehensibility and relevance from a patient perspective, and culturally adapt the Swedish version (HFEQ-SWE).METHOD: A six-step methodology including translation into Swedish according to best practice methodology, evaluation, and cultural adaptation of the HFEQ-SWE using qualitative focus group interviews was used in this study. Thirteen adults with hearing loss were recruited from the audiological clinic in Örebro, Sweden. Their mean age was 57 years, and the four-frequency pure-tone average for the best ear ranged from 5 to 115 dB HL.RESULTS: The results demonstrated that most of the items in the HFEQ-SWE were viewed as relevant by the informants. Not all items were considered relevant for all people, which also reflect the individual variability of everyday functioning. Most items were recognized as comprehensible without any changes needed. CONCLUSIONS: Overall, the results indicate that the translation is semantically and culturally valid from the patient's perspective. Some revisions were suggested that need to be addressed in the further validation process of the HFEQ, and one item was removed.}, issn = {1092-4388} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alloccamariangela_2025, title = {International consensus on the use of intestinal ultrasound in inflammatory bowel disease trials}, author = {Allocca, Mariangela and Jairath, Vipul and Sands, Bruce E. and Rubin, David T. and Caron, Bénédicte and Laurent, Valérie and Novak, Kerri and Panaccione, Remo and Bossuyt, Peter and Bruining, David H. and Dignass, Axel and Dotan, Iris and Fletcher, Joel and Fumery, Mathurin and Furfaro, Federica and Halfvarson, Jonas and Hart, Ailsa and Kobayashi, Taku and Krugliak Cleveland, Noa and Kucharzik, Torsten and Laghi, Andrea and Lakatos, Peter L. and Leong, Rupert W. and Loftus, Edward V. and Louis, Edouard and Magro, Fernando and Olivera, Pablo A. and Sebastian, Shaji and Siegmund, Britta and Vavricka, Stephan R. and Wilson, Stephanie R. and Stoker, Jaap and Rimola, Jordi and Peyrin-Biroulet, Laurent and Danese, Silvio}, year = {2025}, journal = {Journal of Crohn's & Colitis}, volume = {19}, number = {9}, doi = {10.1093/ecco-jcc/jjaf170}, url = {1999665}, language = {eng}, publisher = {Oxford University Press}, keywords = {endpoints; inflammatory bowel disease; intestinal ultrasound}, abstract = {BACKGROUND AND AIMS: Intestinal ultrasound (IUS) is increasingly used to monitor treatment efficacy in inflammatory bowel disease (IBD) trials. However, standardized definitions for response, remission, and optimal assessment timing remain undefined.An international expert consensus meeting was held to establish IUS endpoints for clinical trials.METHODS: A panel of 35 international gastroenterologists and radiologists participated in a modified Delphi process, reviewing the literature and developing consensus statements. Agreement was defined as at least 75% consensus.RESULTS: Consensus was reached on 150 statements across four domains: general IBD (30 statements), luminal Crohn's disease (CD) (43), perianal CD (51), and ulcerative colitis (UC) (26). For luminal CD and UC, ultrasound response was defined by: (1) a ≥ 25% reduction in bowel wall thickness (BWT) from baseline, or (2) multifactorial improvement, combining BWT reduction with ≥1 grade decrease in colour Doppler signal (CDS) or another IUS parameter. Assessments were set at weeks 4-8 for the colon and week 12 for the terminal ileum. Ultrasound remission in luminal CD was defined as: (1) BWT normalization (≤3 mm), or (2) normalization of multiple parameters, including BWT, CDS and all other IUS parameters. Similar remission criteria were proposed for UC, but the sigmoid BWT normal range (3-4 mm) remained uncertain. The bowel ultrasound score (BUSS) for CD and the Milan ultrasound criteria (MUC) for UC were supported as standardized scoring system for trials.CONCLUSION: This consensus provides standardized IUS definitions to enhance consistency in IBD trials, supporting the integration of IUS in future research.}, issn = {1873-9946} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_satrinantonin_2025, title = {International development and validation of a multilingual bank of items for the self-assessment of essential knowledge by systemic lupus erythematosus patients : the SLE Knowledge Assessment score (SLAKE)}, author = {Satrin, Antonin and Piga, Matteo and Gatto, Mariele and Fuentes-Silva, Yurilis and Puerta, José A. Gomez and Padjen, Ivan and Pons-Estel, Guillermo and Ugarte-Gil, Manuel F. and Toro-GutiÉrrez, Carlos Enrique and Legge, Alexandra and Duarte-Garcia, Ali and Chasset, François and Parodis, Ioannis and Baumgaertner, Katia and Chiche, Laurent and Monticielo, Odirlei A. and Oyoo, Omondi and Faria, Raquel and Izuka, Shinji and Silva-Ribeiro, Sofia and Togizbayev, Galymzhan and Opris-Belinski, Daniela and El Kibbi, Lina and Aggarwal, Amita and Maheswaranathan, Mithu and Lee, Tai-Ju and Achieng, Sheilla and Shumilova, Anastasiia and Cervera, Ricard and Chehab, Gamal and Parlindungan, Faisal and Van Leuven, Sander and Lerang, Karoline and Andersen, Jeanette and Marchiori, Francesca and Karakikla-Mitsakou, Zoe and Sordet, Christelle and Arnaud, Laurent}, year = {2025}, journal = {Rheumatology}, doi = {10.1093/rheumatology/keaf649}, url = {2024113}, language = {eng}, publisher = {Oxford University Press}, keywords = {patient medication knowledge; patient-centered care; digital health; digital technologies; education; educational status; health literacy; patient education; patients; systemic lupus erythematosus}, abstract = {OBJECTIVES: Patient education is increasingly acknowledged as an important aspect of the management of systemic lupus erythematosus (SLE). The aim of the study was to develop the SLE Knowledge Assessment score (SLAKE), a digital multilingual self-assessment tool designed to quantify essential SLE knowledge.METHODS: International healthcare professionals (HCPs) and patient representatives engaged in a multi-step process to: identify essential SLE knowledge domains, select key domains via rating, and generate an item bank of 394 questions across 11 domains, which was then adapted into 19 languages. For validation, participants completed 44 questions (including 33 randomly selected), with scores calculated for total knowledge and the 11 specific domains. Statistical analyses examined associations between scores and demographic, clinical, and educational variables.RESULTS: SLAKE was used by 1182 SLE participants (1120 [94.8%] women, median age: 45 years [IQR: 35-54 years]), with a median SLE duration of 10 years (IQR: 4-20 years). The median SLAKE score was 37 (IQR: 34-40) of a maximum of 44 points while the median score across the 11 SLAKE domains ranged between 3 and 4 over a maximum of 4 points. There was a significant positive association between SLAKE score and SLE duration (p= 0.006), previous participation to a patient education course or a patient training for lupus (p< 0.0001) and the education level (p< 0.0001) but not with age (p= 0.48) or gender (p= 0.39).CONCLUSION: SLAKE is a valid, multilingual, digital self-assessment tool that effectively measures essential SLE knowledge. Its randomized question bank and domain-specific scoring enable targeted education, ultimately supporting better disease management.}, issn = {1462-0324} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kermansaravimohammad_2025, title = {International expert consensus on surgery for type 2 diabetes mellitus}, author = {Kermansaravi, Mohammad and Omar, Islam and Stenberg, Erik and Mahawar, Kamal}, year = {2025}, journal = {BMC Endocrine Disorders}, volume = {25}, number = {1}, doi = {10.1186/s12902-025-01961-w}, url = {1981395}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {bariatric surgery; metabolic surgery; type 2 diabetes mellitus}, abstract = {INTRODUCTION: Metabolic and bariatric surgery (MBS) has been an established treatment option for patients with Type 2 diabetes mellitus (T2DM), but there is a relative paucity of evidence-based guidelines on preoperative, operative, and postoperative considerations concerning metabolic surgery for T2DM patients. To address this gap, we initiated a Delphi consensus process with a diverse group of international multidisciplinary experts.METHOD: We embarked on a Delphi consensus-building exercise to propose an evidence-based expert consensus covering various aspects of MBS in patients with T2DM. We defined the scope of the exercise and proposed statements and surveyed the literature through electronic databases. The literature summary and voting process were conducted by 52 experts, who evaluated 44 statements. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria.RESULTS: Consensus, defined as > 80% agreement, was reached for 43 out of 44 statements. The experts reached an agreement on the nature, terminology, and mechanisms of action of MBS. The currently available scores for predicting remission of T2DM after surgery are not robust enough for routine clinical use, and there is a need for further research to enable more personalized treatment. Additionally, they agreed that metabolic surgery for T2DM is cost-effective, and MBS procedures for treating T2DM vary in their safety and efficacy.CONCLUSION: This Delphi expert consensus statement guides clinicians on various aspects of metabolic surgery for T2DM and also grades the quality of the available evidence for each of the proposed statements.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kermansaravimohammad_2025_1, title = {International expert consensus on the current status and future prospects of artificial intelligence in metabolic and bariatric surgery}, author = {Kermansaravi, Mohammad and Shahabi Shahmiri, Shahab and Stenberg, Erik and Zundel, Natan}, year = {2025}, journal = {Scientific Reports}, volume = {15}, number = {1}, doi = {10.1038/s41598-025-94335-0}, url = {1946426}, language = {eng}, publisher = {Nature Publishing Group}, keywords = {bariatric surgery; machine learning; metabolic surgery; simulation training; virtual reality}, abstract = {Artificial intelligence (AI) is transforming the landscape of medicine, including surgical science and practice. The evolution of AI from rule-based systems to advanced machine learning and deep learning algorithms has opened new avenues for its application in metabolic and bariatric surgery (MBS). AI has the potential to enhance various aspects of MBS, including education and training, decision-making, procedure planning, cost and time efficiency, optimization of surgical techniques, outcome and complication prediction, patient education, and access to care. However, concerns persist regarding the reliability of AI-generated decisions and associated ethical considerations. This study aims to establish a consensus on the role of AI in MBS using a modified Delphi method. A panel of 68 leading metabolic and bariatric surgeons from 35 countries participated in this consensus-building process, providing expert insights into the integration of AI in MBS. Of the 28 statements evaluated, a consensus of at least 70% was achieved for all, with 25 statements reaching consensus in the first round and the remaining three in the second round. Experts agreed that AI has the potential to enhance the evaluation of surgical skills in MBS by providing objective, detailed assessments, enabling personalized feedback, and accelerating the learning curve. Most experts also recognized AI's role in identifying qualified candidates for MBS referrals, helping patient and procedure selection, and addressing specific clinical questions. However, concerns were raised about the potential overreliance on AI-generated recommendations. The consensus emphasized the need for ethical guidelines governing AI use and the inclusion of AI's role in decision-making within the patient consent process. Furthermore, the results suggest that AI education should become an essential component of future surgical training. Advancements in AI-driven robotics and AI-integrated genomic applications were also identified as promising developments that could significantly shape the future of MBS.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_caronbndicte_2025, title = {International Magnetic Resonance Imaging Consensus for use in Luminal Crohn's Disease Trials and Clinical Practice}, author = {Caron, Bénédicte and Jairath, Vipul and Sands, Bruce E. and Rubin, David T. and Allocca, Mariangela and Laurent, Valérie and Novak, Kerri and Panaccione, Remo and Bossuyt, Peter and Bruining, David H. and Dignass, Axel and Dotan, Iris and Fletcher, Joel and Fumery, Mathurin and Furfaro, Federica and Halfvarson, Jonas and Hart, Ailsa and Kobayashi, Taku and Cleveland, Noa Krugliak and Kucharzik, Torsten and Laghi, Andrea and Lakatos, Peter L. and Leong, Rupert W. and Loftus, Edward V. and Louis, Edouard and Magro, Fernando and Olivera, Pablo A. and Shaji, Sebastien and Siegmund, Britta and Vavricka, Stephan R. and Danese, Silvio and Stoker, Jaap and Peyrin-Biroulet, Laurent}, year = {2025}, journal = {Clinical Gastroenterology and Hepatology}, doi = {10.1016/j.cgh.2025.08.019}, url = {1993816}, language = {eng}, publisher = {Elsevier}, keywords = {crohn’s disease; magnetic resonance imaging; remission; response; transmural healing}, abstract = {BACKGROUND AND AIMS: Cross sectional imaging is an integral part of evaluating disease activity and complications in Crohn's disease. There remains a need to develop guidance that may be for both clinical trials and clinical practice. This initiative aimed to develop consensus statements for definitions of response and remission, transmural healing, optimal timing for assessing, and evaluation of treatment efficacy in patients with Crohn's disease using magnetic resonance enterography (MRE) in clinical trials and clinical practice.METHODS: Thirty-three international experts (gastroenterologists (n=29) and radiologists (n=4) participated in a consensus process. A systematic literature review was conducted to inform initial consensus, statements were discussed and voted using a modified Delphi method. Consensus was defined as at least 75% agreement among voters.RESULTS: The MaRIA score and the simplified MaRIA score should be used to determine response and remission in moderate to severe Crohn's disease. Response was defined as a MaRIA score <11 or an improvement of at least 25%, and a decrease of at least 1 point in the simplified MaRIA score. Remission was defined as a MaRIA score <7 or a simplified MaRIA score <1. Five different definitions were proposed for transmural healing. For the time point of assessment, the group proposed week 24 for response, weeks 24, 52 or 54 for remission, and weeks 52 or 104 for transmural healing.CONCLUSION: A consensus expert panel has developed standardized definitions of MRE response, remission, as well as the optimal timing for response assessment in patients with luminal Crohn's disease. Further research is needed to clarify the method for measuring transmural healing.}, issn = {1542-3565} } @mastersthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_lindlfsamuel_2025, title = {Internationellt utbyte inom musiklärarutbildning : ett utbildningssammanhang i mångfaldens tjänst?}, author = {Lindlöf, Samuel}, year = {2025}, url = {1952870}, language = {swe}, publisher = {Örebro universitet}, keywords = {musiklärarutbildning; musikundervisning; internationellt utbyte; utbyteskurs; utbytesstudier; interkulturellt lärande; kulturell mångfald; mångkultur.}, abstract = {Syftet med studien är att belysa vilka kunskaper och erfarenheter, relevanta för ett kulturellt mångfaldigt undervisningssammanhang, som musiklärarstudenter tillgodogjort sig och bär med sig efter deltagande i internationellt utbyte. Det slag av internationellt utbyte som avses och undersöks i studien har inte tidigare undersökts i nordisk musikpedagogisk forskning; att vistas i ett annat land i syfte att, inom ramen för sin ordinarie musiklärarutbildning, ta del antingen av en annan musiklärarutbildning eller av musikkurser inom högre utbildning.Bakgrunden är fyrfaldig: lärare behöver en utvecklad kompetens i relation till den kulturella mångfald som råder i grundskolan i Sverige; musikundervisning i grundskolan ska vara mångfaldig och utmana elevernas muskaliska erfarenheter; förberedelse inför arbete i ett kulturellt mångfaldigt undervisningssammanhang förefallar vara, eller ha varit, bristfällig inom lärarutbildning och musiklärarutbildning; utbytesprogram kan ha som ambition att förbereda studenter för, samt hjälpa dem uppnå kompetens att, arbeta i ett globalt sammanhang och nå ett globalt perspektiv på sitt studieområde. Kvalitativa intervjuer har genomförts med nio musiklärarstudenter som studerat vid fyra av landets sju musikhögskolor och deltagit i fem olika utbyten i fem olika länder. Det empiriska materialet har analyserats genom tematisk induktiv analys. Med hjälp av studiens teoretiska utgångspunkt interkulturellt lärande fördjupades analysen. Studien visar bland annat följande: att kontrasteras har gett kunskaper i och om musikpedagogisk, musikalisk och musikdidaktisk mångfald; utifrån erfarenhet av att leva med ett annat språk har reciprokt tänkande utvecklats. Det förstnämnda kan tillämpas i en varitationsrik musikundervisning vars musikaliska innehåll är mångfaldigt. Det nästnämda kan tillämpas genom att sätta sig in i exempelvis en nyanländ elevs situation och behov. Genom utbytesstudierna vunnen förståelse för 'den Andre' finns representerad i tillämpning av både kunskaper och erfarenheter.}, file = {https://oru.diva-portal.org/smash/get/diva2:1952870/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wallenhugo_2025, title = {Internet delivered exposure based cognitive behavior therapy for IBS : A clinical effectiveness study}, author = {Wallen, Hugo and Ljótsson, Brjánn and Lindfors, Perjohan and Forsell, Erik and Hesser, Hugo and Svanborg, Cecilia}, year = {2025}, journal = {American Journal of Gastroenterology}, volume = {120}, number = {4}, pages = {856--863}, doi = {10.14309/ajg.0000000000003059}, url = {1893250}, language = {eng}, publisher = {Blackwell Publishing}, keywords = {cbt; internet; irritable bowel syndrome; ibs; effectiveness; treatment mechanism}, abstract = {INTRODUCTION: Irritable bowel syndrome (IBS) is a common and debilitating disorder. When dietary and pharmacological interventions are not satisfactory, psychological treatment may produce good results. However, the access to such treatment is scarce, and therefore, it is of importance to make use of technical solutions. In this study, we wanted to investigate the real-world effectiveness of an Internet-delivered exposure-based cognitive behavior therapy (ECBT) for IBS and to replicate an earlier finding regarding the working mechanism of the treatment.METHODS: A total of 309 consecutively recruited patients from the Internet Psychiatry Clinic in Stockholm received ECBT for 12 weeks. The patients' IBS symptoms, quality of life, avoidance behaviors, and gastrointestinal symptom-specific anxiety were monitored, and we used a bivariate cross-lagged panel model to investigate time-related change in symptoms and avoidance behaviors. RESULTS: IBS symptoms, measured with the Gastrointestinal Symptom Rating Scale for IBS, were reduced from 48.06 (SD = 11.26) before treatment to 33.06 (SD = 10.81) 6 months after treatment (P < 0.001). The effect size (calculated by Cohen d) was 1.30 (1.08-1.51). There was a significant (P < 0.001) cross-lagged effect from reduction in avoidance behavior to reduction in symptoms but not in the reverse direction, indicating that the treatment effect is mediated by behavioral change.DISCUSSION: We conclude that ECBT is effective under real-world conditions, also when delivered through the Internet, and that an important treatment mechanism is the reduction of avoidance behaviors.}, issn = {0002-9270} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_westerbergbritta_2025, title = {Internet-based psychological treatment for adults with autism : exploring effects, participant experiences, communicative behaviors and sense of coherence}, author = {Westerberg, Britta}, year = {2025}, url = {1963983}, language = {eng}, publisher = {Örebro University}, keywords = {autism; internet-based interventions; sense of coherence}, abstract = {Many individuals with autism suffer from psychiatric comorbidity or experience low life quality, followed by a need for psychological healthcare. However, traditional interventions may not be adapted enough to their needs. Internet-based formats have the potential to increase access to necessary healthcare. Within this project, we developed an internet-based intervention targeting a range of life areas often struggled with by individuals with autism. The overall aim of this thesis is to investigate the feasibility, effectiveness and experiences of - as well as the participants’ communicative patterns in - the internet-based intervention, and to explore the concept sense of coherence in autistic adults. Study I is a longitudinal RCT evaluating the effects of the internet-based intervention in the quality of life and psychiatric symptoms of the participants. Study II is a qualitative interview study exploring the participant experiences of the intervention. Study III is a mixed method study exploring the participant’s communicative behavior during the intervention, and their potential relation to clinical outcomes. Study IV is a cross-sectional study investigating the sense of coherence among autistic individuals and its relation to autistic traits and quality of life.The findings of the four studies that constitute this thesis enhance our understanding of how an internet-based intervention can be adapted, implemented, and evaluated for individuals with autism. Furthermore, they provide insight into communicative behaviors that may be beneficial for participants to engage in during such an intervention, as well as clarify the relationship between autistic traits and sense of coherence in adults with autism.}, file = {https://oru.diva-portal.org/smash/get/diva2:1963983/FULLTEXT03.pdf} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_mouazzenannakarin_2025_1, title = {Interprofessional team collaboration and work environment in the occupational health service in Sweden : The professionals’ perspective}, author = {Mouazzen, Anna-Karin}, year = {2025}, url = {1947269}, language = {eng}, publisher = {Örebro University}, keywords = {interdisciplinary research; interprofessional relations; occupational health; occupational healthcare; occupational health services; occupational health and safety; team collaboration}, abstract = {The occupational health service (OHS) constitutes an independent resource with competence to identify and describe connections among work environments, organizations, productivity, and health, and can prevent and eliminate health risks in the workplace, for the best public health of the workforce. To do this, the OHS needs to be interdisciplinary. Therefore, the overall aim of this thesis was to investigate and explore interprofessional team collaboration (ITC) in the OHS in Sweden by measuring, describing, and comparing professionals’ per-ceptions and experiences of ITC and psychological and social factors in their work environment. Three quantitative studies and one qualitative study was conducted. A psychometric study was conducted to adapt and evaluate the Assessment of Interprofessional Team Collaboration Scale (AITCS) (Study I). Data collected with AITCS-SII(OH) and the General Questionnaire for Psychological and Social Factors at Work (QPS-Nordic) were used to compare and describe perceptions and experiences of professionals in the OHS (Studies II–III). Five focus group discussions (FGDs) were conducted to explore the experiences of ITC (Study IV). The findings show that AITCS-SII(OH) is a valid and reliable tool in this context, there are differences and similarities within the professionals’ experience of ITC and their work environment. Specialist education in occupational health and safety and type of OHS may influence perceptions and experiences of ITC and the work environment. Evidence Based Practice needs to be implemented further in the OHS and the OHS need to develop and promote ITC.}, file = {https://oru.diva-portal.org/smash/get/diva2:1947269/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_mobergnadia_2025, title = {Interrogating Power in Music Research : Critical Observations}, author = {Moberg, Nadia and Georgii-Hemming, Eva}, year = {2025}, url = {1996857}, language = {eng}, abstract = {The research program Music, Power and Inequities (MPI) brings together scholars with a shared interest in power in musical practices and institutions at Örebro University. MPI was established on the recognition that music’s celebrated potential for cohesion is paralleled by musical practices and institutions that sustain exclusion and inequity.There is, for instance, a long-established belief that music fosters cooperation and moral standards. The European Commission (2022) argues that music “has the power to bring positive changes in society”, yet research shows that unequal relations and forms of exclusion persist across musical contexts. Music spaces, from conservatories to recording studios, have been sites of sexual harassment and abuse, as demonstrated by the #metoo campaign (Bull et al. 2023); professional opportunities are shaped by prejudice (Ålander & Volgsten 2021); and music-making and consumption are divided by class, gender, and ethnicity (Angelo et al. 2019; Bull & Scharff 2021; Moberg 2019). In addition, music has been used by anti-democratic movements, to promote racist, xenophobic agendas (de Boise 2024).In this paper, we present findings from a scoping review of contemporary research on power in musical practices and institutions, conducted within MPI. Through an examination of peer-reviewed articles addressing inequ(al)ities related to various aspects of music, we show that research on music and power places strong emphasis on gender, race, and social justice. While the concepts of power and inequality are frequently invoked, they are rarely defined. We outline three central lines of critique: (1) power is often addressed implicitly, without attention to the relational dynamics through which it operates; (2) inequality and inequity are commonly framed as issues of representation or attitudes, rather than as outcomes of unequal distribution of resources; and (3) barriers to analysing power are reinforced by epistemic inequalities within academic research itself. Together, these findings point to the need for more explicit, structural, and relational analyses of power in music research.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_piggottlucy_2025, title = {Intersectional Perspectives on Digitized Sports Cultures}, author = {Piggott, Lucy and Lenneis, Verena and Alsarve, Daniel}, year = {2025}, pages = {13--30}, doi = {10.4324/9781003527565-3}, url = {2001450}, language = {eng}, publisher = {Routledge}, abstract = {The emergence of digitized sports cultures has been characterized by complex and non-linear gender relations and power dynamics. For the most part, research on this topic has been conducted and analysed from a one-dimensional perspective that homogenizes the realities and experiences of women and men, and positions gender as the single most significant marker of social inequality. Consequently, this scholarship has been limited in its exploration of how different social conditions lead to diverse experiences of privilege and othering among women, men, and non-binary people operating in digitized sporting spaces. The purpose of this chapter is to advocate for the value of examining digitized sports cultures through an intersectional lens. We first exemplify where intersectional perspectives have been applied and the insights they contribute. We then discuss how intersectional theory could be further applied to extend knowledge and insight into the complex reality of gender inclusion in digitized sports spaces.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_anderssonsusannab_2025, title = {Intimate Publics in and through Swedish Conversational Podcasts}, author = {Andersson, Susanna B.}, year = {2025}, pages = {130--130}, url = {2018723}, language = {eng}, publisher = {NTNU}, abstract = {Podcasting and podcast listening have evolved into activities with significant social impact potential. According to Spotify (2024:4), 42% of Swedes listen to podcasts at least once a week, and more than half of the listeners feel such a strong sense of community with the podcasters that they consider them friends (Acast 2024).This CA-based study of 40 Swedish conversational podcasts aims to identify how Swedish podcasters create interactional intimacy and achieve an intimate public, defined as “a porous, affective scene of identification among strangers” (Berlant 2020:viii). The podcast medium's capacity to foster a ‘hyper-intimacy’ (Berry 2016) between participants and listeners – linked to individual and mobile listening, technological accessibility, and the content and format of the podcasts – has been cited as a reason for its growing popularity (Berry 2016; Swiatek 2018; Spinelli & Dann 2019). This study aligns with Euritt’s (2023) perspective of podcast intimacy as socially constructed discourses rather than an inherent quality of the medium. The analysis builds on two of Adler Berg’s (2023) analytical parameters: intimacy in what is said (e.g. topics’ breadth and sensitivity, subjective or personal information) and in how it is said (e.g. non-lexical vocalisations).Preliminary findings suggest that regardless of the podcast's focus (e.g. sports, humour), podcasters share their experiences of pleasures and pains using similar emotional wording and non-lexical vocalisations. However, differences in emotional intensity seem to be closely related to the participants' perception of their target audience, as expressed through epistemic presuppositions and frames of reference.References:Acast (2024). Podcasting trends in established vs. emerging markets: Acast's global report for international podcast day - September 30th, 2024. Acast.Adler Berg, F. S. (2023). Analysing podcast intimacy: Four parameters. Convergence: The International Journal of Research into New Media Technologies [Advance online publication]. https://doi.org/10.1177/13548565231220547Berlant, L. (2020). The female complaint: The unfinished business of sentimentality in American culture. Duke University Press.Berry, R. (2016). Part of the establishment: Reflecting on 10 years of podcasting as an audio medium. Convergence: The International Journal of Research into New Media Technologies 22(6), pp. 661-671. Euritt, A. (2023). Podcasting as an intimate medium. London: Routledge.Spinelli, M. & Dann, L. (2019). Podcasting: The audio media revolution. London: Bloomsbury Academic.Spotify (2024). Poddrapporten 2024. Spotify.Swiatek, L. (2018). The podcast as an intimate bridging medium. In Llinares, D., Fox, N. & Berry, R. (eds.) Podcasting: New aural cultures and digital media. Cham: Springer International Publishing, pp. 173-187} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nguyenanhhoang_2025, title = {Intra- and inter-individual variation of the human lipidome}, author = {Nguyen, Anh Hoang and Beyene, Habtamu B. and Mocciaro, Gabriele and Hahnefeld, Lisa and Lamichhane, Santosh and Fabritius, Mikael and Avela, Henri and Wang, Yuqin and Dickens, Alex M. and Gurke, Robert and Yang, Baoru and Griffiths, William J. and Hyötyläinen, Tuulia and Meikle, Peter J. and Oresic, Matej}, year = {2025}, journal = {TrAC. Trends in analytical chemistry}, volume = {191}, doi = {10.1016/j.trac.2025.118368}, url = {1995072}, language = {eng}, publisher = {Elsevier}, keywords = {inter-individual variation; intra-individual variation; human lipidome; lipidomics; mass spectrometry}, abstract = {Lipids play essential roles in cellular functions such as membrane structure, signaling, and energy storage. Lipidomics-global study of lipids in cells and tissues-seeks to identify biomarkers and uncover underlying metabolic pathways. Human lipid concentrations in cells and biofluids can fluctuate at multiple temporal scales, reflecting normal biochemical and physiological variation, or responses to various internal and external stimuli. Understanding both intra- and inter-individual lipid variability is crucial for accurate lipidomics study design and interpretation. This knowledge also supports personalized healthcare, moving beyond static reference ranges. Here, we review key drivers of intra-individual variation, including diet, circadian rhythms, sleep, environmental exposures, and physiological states. We also examine inter-individual factors such as genetics, age, sex, microbiome composition, and medications. Finally, we discuss how these variables interact and influence lipidomics outcomes, aiming to enhance reproducibility and guide future research.}, issn = {0165-9936} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_friskhenrik_2025, title = {Intraoperative neurophysiological monitoring in surgery for intramedullary spinal cord lesions - workflow, setup and outcomes}, author = {Frisk, Henrik and Margaryan, Gayane and Buwaider, Ali and Sargsyan, Davit and El-Hajj, Victor Gabriel and Majing, Tomas and Singh, Aman and Fletcher-Sandersjöö, Alexander and Persson, Oscar and Staartjes, Victor E. and Persson, Jonas K. E. and Edström, Erik and Elmi-Terander, Adrian}, year = {2025}, journal = {Acta Neurochirurgica}, volume = {167}, number = {1}, doi = {10.1007/s00701-025-06697-z}, url = {2009125}, language = {eng}, publisher = {Springer}, keywords = {functional outcome; intramedullary spinal cord lesion; intraoperative monitoring; intraoperative neurophysiological monitoring; spine; workflow}, abstract = {OBJECTIVE: Gross total resection is strived for in intramedullary spinal cord lesion surgery. Intraoperative neurophysiological monitoring (IONM) is the gold standard, but there is no consensus on the optimal IONM workflow. This study details our institutional workflow.METHODS: We retrospectively reviewed all adults who underwent intramedullary resection at Karolinska University Hospital, 2007-2021 (n = 70). Continuous multimodal IONM (somatosensory-evoked potentials (SSEP), motor-evoked potentials (MEP) and epidural D-waves) was conducted by an in-room neurophysiologist. Alarm thresholds were preset (≥ 50% SSEP amplitude drop/10% latency rise; ≥ 80% MEP reduction; ≥ 50% D-wave loss) and triggered a standardized four-step rescue protocol (halt manipulation, raise MAP to 80-90 mm Hg, topical papaverine, observation). Motor/sensory function, modified McCormick (mMC) grade, pain, and sphincter control were documented pre-operatively, at 3 months, and ≥ 12 months.RESULTS: Seventy patients were included. Most harboured ependymoma (51%), hemangioblastoma (18%) and cavernoma (8.5%). A neurophysiologist was present during every procedure. A ≥ 50% intra-operative SSEP-amplitude decrease was not followed by a sensory deficit (OR:3.0, 95% CI 0.86-10.6; p = 0.085) or mMC deterioration (OR:1.6, 0.33-7.5; p = 0.57) at either short- or long-term follow-up. In contrast, complete SSEP loss markedly increased the risk of postoperative sensory deficit (3-months-OR:25.2, 4.7-135; p < 0.001; long-term-OR 11.0, 2.8-43.8; p < 0.001) and poorer mMC grade (3-months-OR:7.8, 2.0-31; p = 0.004; long-term-OR:11.0, 2.8-43.8; p < 0.001). Loss of MEPs predicted a decline in mMC at long-term follow-up (OR:4.0, 1.06-15.1; p = 0.041).CONCLUSIONS: Live data from continuous intraoperative neurophysiological monitoring, expertly interpreted in the OR, could potentially be used to make surgical and anesthesiologic adjustments with the goal of minimizing the risk of negative neurological outcomes. Significant associations were found between decreased or lost IONM signals and poorer sensorimotor function and mMC score at short- and long-term follow-up. Implementation of the IONM workflow is suggested in all intramedullary surgery.}, issn = {0001-6268} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_joelssontanja_2025, title = {Introducing care-full everyday bus mobilities : challenges and ways forward for livable and just public mobilities}, author = {Joelsson, Tanja and Balkmar, Dag and Henriksson, Malin}, year = {2025}, journal = {Applied Mobilities}, pages = {1--16}, doi = {10.1080/23800127.2025.2465154}, url = {1939128}, language = {eng}, publisher = {Routledge}, keywords = {public transport; bus mobilities; diversity; affect; care}, abstract = {In this editorial, we will engage with the growing literature on public transport, predominantly in the social sciences, with a particular emphasis on research concerned with the bus and bus mobilities. We aim to provide a review of research on bus mobilities, but also to discuss some ways forward in studying bus mobilities. In our reading of the literature to date, we are particularly interested not only in the ways bus mobilities are conceptualized, but also what different theoretical and analytical framings do with the knowledge produced. First, we turn to address how diversity and difference in the context of the bus as a public space has been investigated. Second, we consider how bus mobilities are related to social inequalities. Third, we highlight scholarly work on the affective and material dimensions of bus mobilities. Following these lines of research and in order to make sense of the bus as a socio-material artifact, and the implications of bus mobilities in contemporary societies, we will center the discussion in relation to recent calls in mobilities research, in urban studies and in human geography at large, on care (Gabauer et al. Citation2021; Lawson Citation2007; Middleton and Samanani Citation2021; Power and Mee Citation2020; Power and Williams Citation2020). Before introducing the contributions to this special issue, we thus return to matters of care: whether or not bus mobilities might benefit from being considered an infrastructure of care; how approaches of social equality and justice can harness care; and what placing care at the center of mobility research and practice entails amid current times of crises.}, issn = {2380-0127} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_anckarcarsten_2025, title = {Introducing Comparative Death Penalty Database (CDPD)}, author = {Anckar, Carsten and Denk, Thomas}, year = {2025}, journal = {European Political Science}, volume = {24}, number = {2}, pages = {261--272}, doi = {10.1057/s41304-024-00491-8}, url = {1885452}, language = {eng}, publisher = {Palgrave Macmillan}, keywords = {death penalty; capital punishment; global historical data; dataset}, abstract = {The death penalty is a unique form of punishment as it is the most consequential penalty with no options for reversibility. Politically, it is a highly controversial form of punishment, the usage of which varies strongly between and within countries over time. Existing databases on death penalty usage generally cover a time period from the 1950s and onwards. In this article, we introduce a new database that covers the period 1800-2022 for all currently independent countries in the world. We provide a yearly categorization of death penalty status as well as changes of the status. In descriptive analyses, we show how the new data provides a more comprehensive picture of the development of death penalty trends worldwide. The database provides researchers with new opportunities to study the death penalty from a variety of perspectives.}, issn = {1680-4333} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bergjenny_2025_1, title = {Introducing the comparative semi-presidential database (CSPD)}, author = {Åberg, Jenny and Denk, Thomas}, year = {2025}, journal = {European Political Science}, volume = {24}, number = {4}, pages = {706--720}, doi = {10.1057/s41304-024-00499-0}, url = {1906644}, language = {eng}, publisher = {Palgrave Macmillan}, keywords = {semi-presidentialism; premier-presidentialism; president-parliamentarism; institutional studies; political regimes}, abstract = {In this article, we introduce a new dataset-the Comparative Semi-Presidential Database (CSPD)-covering classifications of semi-presidential regimes. In contrast to other databases, the CSPD offers several classifications based on different definitions of semi-presidential regimes along with subtypes of semi-presidential regimes. We use definitions developed by Elgie (in: Elgie (ed) Semi-presidentialism in Europe, Oxford University Press, Oxford, 1999), Cheibub et al. (Public Choice 143:67-101, 2010), Shugart (French Politics 3(3):323-351, 2005) and Shugart and Carey (Presidents and assemblies: constitutional design and electoral dynamics, Cambridge University Press, New York, 1992). Additionally, we present a modified definition of semi-presidential regimes based on the conceptual discussion in the field. The database covers all independent states from 1900 to 2021. Using empirical analyses, we compare the classifications, the importance of conceptualisation and presenting our measurement for semi-presidential regimes.}, issn = {1680-4333} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_mazurstepan_2025, title = {Introduction}, author = {Mazur, Stepan and Österholm, Pär}, year = {2025}, pages = {1--6}, doi = {10.1007/978-3-032-00110-8_1}, url = {2012566}, language = {eng}, publisher = {Springer}, abstract = {This chapter gives a brief introduction to the Festschrift. A short overview of Sune Karlsson’s career and research is provided. In addition, the content of each chapter is presented.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_zucconibenedetta_2025, title = {Introduction}, author = {Zucconi, Benedetta and Volgsten, Ulrik}, year = {2025}, pages = {i--xiii}, doi = {10.1007/978-3-031-98261-3}, url = {2002201}, language = {eng}, publisher = {Palgrave Macmillan}, abstract = {This edited volume offers a new perspective on the new objectivity movement in music during the interwar period, challenging the view of it as a solely German or Berlin-based movement. Unlike architecture or visual arts, musicology has rarely applied the term beyond Germany. Yet, new objectivity in music—spanning composition, performance, and listening—had significant European expressions. Key features included a rejection of expressionism, interest in mechanical reproduction (radio, gramophone), and objective performance styles. Through historiographical analysis and diverse case studies from several European countries, the book presents the movement as a broader, locally rooted phenomenon reflecting a shared Zeitgeist. It explores how these ideas emerged independently across national contexts, offering new insights into the cultural and political dynamics of the period. By examining aesthetic, institutional, political, and performative dimensions, the book invites a rethinking of new objectivity as a transnational and multifaceted phenomenon, and proposes its relevance as a tool for historiographical inquiry in music studies.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_arenasfr_2025_1, title = {Introduction}, author = {Arenas, F.R. and Van Belle, Jono and Peirano, M.P.}, year = {2025}, pages = {1--15}, url = {2028596}, language = {eng}, publisher = {Berghahn Books} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_barkerruchtinatalie_2025_2, title = {Introduction}, author = {Barker-Ruchti, Natalie and Purdy, Laura}, year = {2025}, pages = {1--6}, doi = {10.4324/9781003439646-1}, url = {2028586}, language = {eng}, publisher = {Taylor & Francis}, abstract = {The idea for this book stems from our efforts to prepare engaging and challenging teaching materials for sports coaching education in higher education (HE) contexts. We both have a long-standing interest in educating coaches, who become empowered through competences such as critical reflection, creative thinking, learning on the edge and adaptability. In considering how such competences can be instilled, we have over the years separately and collaboratively explored alternative pedagogical means and engaged in developing coach education programmes, university courses and curricular content. In 2013, we got to know Education for Sustainable Development (ESD), UNESCO’s educational framework to tackle global challenges such as climate change, inequality and loss of biodiversity. This approach turned our focus more purposefully on developing quality-of-mind competences (e.g., [self-]reflection, critical thinking and the consideration of multiple knowledges to understand self and others). Since then, our interest in alternative pedagogies in sports coaching education in HE has included efforts to make such curricular materials available to others. } } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_thunbergsara_2025_3, title = {Introduction : Children in Domestic Violence Shelters}, author = {Thunberg, Sara and Arnell, Linda and Källström, Åsa}, year = {2025}, pages = {1--9}, doi = {10.1007/978-3-031-95477-1_1}, url = {2003075}, language = {eng}, publisher = {Palgrave Macmillan}, abstract = {The first chapter in the book Children in Domestic Violence Shelters: International Perspectives introduces the consequences of domestic violence for mothers and their children, and the importance of support and safety. The introduction also presents the UN Convention on the Rights of the Child (UNCRC) and Agenda 2030 as a framework for the book, both stressing that children need to be protected from violence. The introduction ends with a disposition of the book, and the 12 chapters included.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_torresanlia_2025, title = {Introduction: Feminisms and Gender Studies : Convergences, Divergences, and Pluralities}, author = {Torres, Anália and Pinto, Paula Campos and Schefer, Tamara and Hearn, Jeff}, year = {2025}, pages = {1--9}, doi = {10.4324/9781003253068-1}, url = {1922472}, language = {eng}, publisher = {Routledge}, keywords = {feminism; feminisms}, abstract = {This chapter overviews the focus, structure and cross-cutting themes of the handbook. It speaks to the unique nature of the handbook, which brings together essays from renowned feminist and gender studies academics from the ‘global North’ and ‘global South’, as well as emerging and established scholars. Structured in three parts, the volume offers an overview of the state of the art of feminist and gender studies across the globe in the last 40 years; identifies key cross-cutting theoretical debates and controversies and addresses methodological and empirical research questions signalling the need to promote new approaches. Notwithstanding the geopolitical diversity of the volume, the chapter surfaces emergent themes including the significant institutionalisation of gender studies; resurgence of attacks on feminist scholarship and activists; the strong presence of young scholars addressing new agendas; role of international organisation/s and transnational solidarities and challenges of neoliberal market logics and continued geopolitical inequalities in current academic forms of gender studies. The chapter further points to emergent topics, directions and paradoxes in feminist scholarship represented in the handbook.}, file = {https://oru.diva-portal.org/smash/get/diva2:1922472/FULLTEXT01.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_erikssongran_2025, title = {Introduction : Food Marketing and Selling Healthy Lifestyles with Science}, author = {Eriksson, Göran and O’Hagan, Lauren Alex}, year = {2025}, pages = {1--18}, doi = {10.4324/9781003450276-1}, url = {1927194}, language = {eng}, publisher = {Routledge}, abstract = {This chapter sets out the key aims and focus of the edited volume, arguing that the use of scientific discourse in food marketing has a long history dating back to the mid-nineteenth century. Drawing upon key examples from the authors’ many years of research in the area, it outlines why it is necessary to study this topic from both a transhistorical and multimodal perspective and the important insights that this can offer into contemporary food marketing. The chapter also underscores four key themes that run across the 13 chapters that make up the volume—scientific motherhood; the paradoxical blend of science with tradition and/or nature; hygiene and cleanliness in relation to food safety and health values; and healthism and the medicalisation of everyday life—as well as key studies to have been carried out in these important areas of research. It ends by appealing for further dialogue and transhistorical, multimodal studies in order to enrich our understanding of the link between science, food marketing and healthy lifestyles.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_seymourkate_2025_1, title = {Introduction : Interconnecting the violences of men}, author = {Seymour, Kate and Pease, Bob and Strid, Sofia and Hearn, Jeff}, year = {2025}, pages = {1--26}, url = {1919836}, language = {eng}, publisher = {Routledge}, keywords = {violence; gender; men; masculinities; interconnections}, abstract = {The introductory chapter provides a rationale for the book, outlining how the gendering of men’s violence in specific fields have failed to consider the interconnections, intersections, and continuities between these fields. Naming only some violences as gendered enables other violences to go unmarked. We argue that that all violences are gendered, even when they are not perpetrated by men. We review the key issues in specific fields of gendered violences including men’s violence against women, children and young people, other men, gay, trans and non-binary people, disabled people and men’s violence against themselves. We also consider how gendered violence is enacted through colonialism, militarism and war, and in relation to non-human animals and the environment, as well as through epistemic injustice. }, file = {https://oru.diva-portal.org/smash/get/diva2:1919836/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_schindlermaike_2025_1, title = {Introduction to eye tracking in mathematics education : interpretation, potential, and challenges}, author = {Schindler, Maike and Shvarts, Anna and Lilienthal, Achim J.}, year = {2025}, journal = {Educational Studies in Mathematics}, volume = {118}, pages = {309--321}, doi = {10.1007/s10649-025-10393-1}, url = {1945010}, language = {eng}, publisher = {Springer}, issn = {0013-1954} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_denkthomas_2025, title = {Introduktion}, author = {Denk, Thomas and Anckar, Carsten}, year = {2025}, pages = {11--40}, url = {2031940}, language = {swe}, publisher = {Studentlitteratur AB} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hilgermaximilian_2025, title = {Introspective Loop Closure for SLAM with 4D Imaging Radar}, author = {Hilger, Maximilian and Kubelka, Vladimír and Adolfsson, Daniel and Becker, Ralf and Andreasson, Henrik and Lilienthal, Achim}, year = {2025}, pages = {6175--6182}, doi = {10.1109/ICRA55743.2025.11127330}, url = {2026862}, language = {eng}, publisher = {IEEE}, abstract = {Simultaneous Localization and Mapping (SLAM) allows mobile robots to navigate without external positioning systems or pre-existing maps. Radar is emerging as a valuable sensing tool, especially in vision-obstructed environments, as it is less affected by particles than lidars or cameras. Modern 4D imaging radars provide three-dimensional geometric information and relative velocity measurements, but they bring challenges, such as a small field of view and sparse, noisy point clouds. Detecting loop closures in SLAM is critical for reducing trajectory drift and maintaining map accuracy. However, the directional nature of 4D radar data makes identifying loop closures, especially from reverse viewpoints, difficult due to limited scan overlap. This article explores using 4D radar for loop closure in SLAM, focusing on similar and opposing viewpoints. We generate submaps for a denser environment representation and use introspective measures to reject false detections in feature-degenerate environments. Our experiments show accurate loop closure detection in geometrically diverse settings for both similar and opposing viewpoints, improving trajectory estimation with up to 82% improvement in ATE and rejecting false positives in self-similar environments.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_lahoudalan_2025, title = {Inverse Optimization Latent Variable Models for Learning Costs Applied to Route Problems}, author = {Lahoud, Alan and Schaffernicht, Erik and Stork, Johannes Andreas}, year = {2025}, url = {2019669}, language = {eng}, keywords = {inverse optimization; latent space}, abstract = {Learning representations for solutions of constrained optimization problems (COPs) with unknown cost functions is challenging, as models like (Variational) Autoencoders struggle to enforce constraints when decoding structured outputs. We propose an Inverse Optimization Latent Variable Model (IO-LVM) that learns a latent space of COP cost functions from observed solutions and reconstructs feasible outputs by solving a COP with a solver in the loop. Our approach leverages estimated gradients of a Fenchel-Young loss through a non-differentiable deterministic solver to shape the latent space. Unlike standard Inverse Optimization or Inverse Reinforcement Learning methods, which typically recover a single or context-specific cost function, IO-LVM captures a distribution over cost functions, enabling the identification of diverse solution behaviors arising from different agents or conditions not available during the training process. We validate our method on real-world datasets of ship and taxi routes, as well as paths in synthetic graphs, demonstrating its ability to reconstruct paths and cycles, predict their distributions, and yield interpretable latent representations.}, file = {https://oru.diva-portal.org/smash/get/diva2:2019669/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rohkyoungho_2025, title = {In-vitro Activities of Zoliflodacin and Solithromycin Against Neisseria gonorrhoeae Isolates from Korea}, author = {Roh, Kyoung Ho and Luong, Nguyen Dinh and Liu, Changseung and Seo, Young Hee and Lee, Hyukmin and Unemo, Magnus and Lee, Kyungwon}, year = {2025}, journal = {Annals of laboratory medicine}, volume = {45}, number = {6}, pages = {626--629}, doi = {10.3343/alm.2024.0522}, url = {1955123}, language = {eng}, publisher = {Korean Society for Laboratory Medicine}, keywords = {antimicrobial resistance; azithromycin; cefixime; ceftriaxone; gonorrhea; neisseria gonorrhoeae; sexually transmitted infections; solithromycin; spectinomycin; zoliflodacin}, abstract = {Novel antimicrobial agents are continually developed to address the global threat of multidrug-resistant Neisseria gonorrhoeae. Promising candidates include zoliflodacin and, possibly, solithromycin. We evaluated their in-vitro activities against gonococcal isolates collected in Korea. In total, 250 N. gonorrhoeae isolates obtained across Korea between 2016 and 2018 were used to determine the minimum inhibitory concentrations (MICs) of 10 therapeutic agents using the CLSI agar dilution method. Most isolates (94.8%, 237/250) demonstrated non-susceptibility to penicillin G, tetracycline, and ciprofloxacin, and susceptibility to ceftriaxone and spectinomycin was substantially high. The half-maximal IC (MIC50) and 90% IC (MIC90) values for zoliflodacin were 0.03 and 0.06 μg/mL, respectively; 0.06 and 0.12 μg/mL, respectively, for solithromycin; and 0.03 and 0.12 μg/mL, respectively, for ceftriaxone. Notably, no cross-resistance was observed between zoliflodacin and ciprofloxacin, despite both targeting DNA topoisomerase II enzymes. Zoliflodacin and solithromycin demonstrated significant in-vitro activity against multidrug-resistant N. gonorrhoeae isolates, and zoliflodacin has shown non-inferiority to ceftriaxone/azithromycin dual therapy in a clinical phase 3 trial. Collectively, our findings highlight the potential of zoliflodacin as a novel therapeutic agent for gonococcal infections, particularly in the context of rising multidrug resistance, and highlight the need for continued surveillance and development of alternative antimicrobial strategies.}, issn = {2234-3806} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mcgreevydavid_2025, title = {In-Vivo Optical Spectroscopy (INVOS) as a Prognostic Tool for Peripheral Artery Disease During Endovascular Intervention : A Pilot Study}, author = {McGreevy, David and Hörer, Tal M. and Petri, Marcelo}, year = {2025}, journal = {Journal of Endovascular Therapy}, doi = {10.1177/15266028251380182}, url = {2003815}, language = {eng}, publisher = {Sage Publications}, keywords = {acute limb ischemia; endovascular treatment/therapy; intermittent claudication; ischemia; peripheral artery disease; revascularization}, abstract = {INTRODUCTION: Peripheral arterial disease (PAD), including intermittent claudication (IC) or critical limb ischemia (CLI), can be treated with endovascular revascularization; however, tools for intraoperative prognostication are limited. The In-Vivo Optical Spectroscopy (INVOS) system, a non-invasive near-infrared spectroscopy device, measures tissue oxygenation. This pilot study aims to investigate the use of INVOS during endovascular surgery for PAD as a prognostic tool for endovascular PAD treatment. This study is intended as a feasibility and hypothesis-generating pilot, rather than one designed to draw definitive conclusions.METHODS: Thirty patients with PAD undergoing endovascular treatment were prospectively enrolled. In-Vivo Optical Spectroscopy sensors were applied to the treated foot preoperatively. Measurements were recorded preoperatively, postoperatively, and at 1, 2, and 3 hours post-surgery. Raw INVOS values and INVOS/systolic blood pressure (SBP) ratios were calculated and normalized to baseline values to determine fold changes. Clinical outcomes were assessed at 30 days.RESULTS: No significant changes in raw INVOS or SBP values were observed before or after the procedure in both IC and CLI groups. However, the normalized INVOS/SBP ratio was significantly higher in IC patients at 1 and 2 hours postoperatively (p<0.05). A fold change greater than 1.25 was associated with better clinical outcomes, including fewer complications and higher rates of patient- and physician-reported improvement.CONCLUSION: An INVOS/SBP ratio fold change greater than 1.25-fold is associated with improved outcomes following endovascular intervention for PAD. In-Vivo Optical Spectroscopy may serve as a valuable intraoperative prognostic tool, particularly in IC patients. Further studies are needed to validate these findings.Clinical ImpactThe clinical impact of the current work is to improve the knowledge in the application of INVOS measurements peri operative in clinical practices and improve patients care. Post operative surveillance with INVOS could be used to confirm surgical success. INVOS ratio lower than 1.25-fold after first revascularization should be reassessed and improve blood flow towards the limb. Although limited, this pilot study shows that the use of INVOS can be an adjuvanted tool in monitoring surgical outcomes in patients with PAD.}, issn = {1526-6028} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_thunbergsara_2025_4, title = {Inzicht in het hulpzoekgedrag van jongeren  na slachtofferschap en het daarop afstemmen van de indersteuning : [Understanding Youth’s Help-Seeking Behaviors After Criminal Victimization and How to Match Support Services]}, author = {Thunberg, Sara}, year = {2025}, pages = {245--266}, url = {2016611}, language = {dut}, publisher = {Owl Press} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zhengweihua_2025, title = {Is low-volume high intensity interval training a time-efficient strategy for improving body composition and cardiovascular health in children and adolescents? Evidence from a systematic review and three-level meta-analysis}, author = {Zheng, Weihua and Xing, Yue and Yin, Mingyue and Guo, Yan and Piao, Shunzhe and Cao, Yang and Chen, Hongbo and Li, Hansen}, year = {2025}, journal = {Frontiers in Physiology}, volume = {16}, doi = {10.3389/fphys.2025.1736441}, url = {2026024}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {lv-hiit; adolescents; body composition; cardiovascular health; children; time-efficient strategy}, abstract = {OBJECTIVES: This meta-analysis assessed the impact of low-volume high-intensity interval training (LV-HIIT) on body composition and cardiovascular health in children and adolescents, while examining potential moderating factors.METHODS: A systematic search was conducted in PubMed, Web of Science, the Cochrane Library (CENTRAL), and CNKI from inception to April 2025. A three-level random-effects model was used to estimate the overall effects, and subgroup analyses supplemented with meta-regression were performed to explore potential moderators and sources of heterogeneity.RESULTS: A total of 23 studies (996 participants, including 246 females) were included, with 6 studies on normal-weight and 17 on overweight/obese individuals. Compared with controls, low-volume high-intensity interval training (LV-HIIT) significantly reduced BMI (g = -1.24), fat mass (g = -0.99), body fat (g = -0.89), waistline (g = -0.42), weight (g = -0.34), and SBP (g = -0.37), while improving VO2max (g = 1.35). No significant differences were observed versus MICT. Subgroup and dose-response regressions suggested that weight status, age, intervention duration, training frequency, repetitions, and per-repetition time may alter the observed effects. Descriptive findings indicated comparable effects of LV-HIIT with small-sided games and sprint interval training but greater benefits over moderate-intensity interval training.CONCLUSION: LV-HIIT can effectively and time-efficiently improve body composition and cardiovascular health in children and adolescents, with overall effects comparable to MICT. Exercise prescriptions should carefully consider weight status, age, and intervention characteristics; however, given the limited number of studies and potential bias, the conclusions should be interpreted with caution. Limited descriptive comparisons indicate that LV-HIIT produces effects similar to SSG and SIT, and may offer greater benefits than MIIT.SYSTEMATIC REVIEW REGISTRATION: https://osf.io/exhjm/.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gustafssonkarinm_2025, title = {Is science to be trusted? How environmentally active youths relate to science in social media}, author = {Gustafsson, Karin M}, year = {2025}, journal = {Public Understanding of Science}, volume = {34}, number = {1}, pages = {76--91}, doi = {10.1177/09636625241249915}, url = {1862074}, language = {eng}, publisher = {Sage Publications}, keywords = {discourse analysis; fältbiologerna; fridays for future; science; social media; trust}, abstract = {Research has shown a great distrust among youths toward political representatives, who they demand should “listen to the science.” However, less research has been done on youths’ own trust in science. This study explores and explains how youths who are environmentally active in two different environmental youth organizations relate to science in social media, whether they trust science, and how youths’ relation to science creates a discursive context in which they may develop their identity. The study uses the approach of discourse analysis to examine social media content published on Facebook by Fridays for Future Sweden and Fältbiologerna (the Swedish Field Biologists). The study shows (i) how subject positions for scientists and youth are created in relation to one another based on different expressions of youths’ trust in science and(ii) how environmental youth organizations, by identifying with science, make youths important actors in the discourse on climate change.}, issn = {0963-6625} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_thulemarkmaria_2025, title = {It takes a team to participate - Refining working participant observations through multiple researchers}, author = {Thulemark, Maria and Heldt Cassel, Susanna and Duncan, Tara}, year = {2025}, journal = {Area (London 1969)}, volume = {57}, number = {3}, doi = {10.1111/area.70012}, url = {1951184}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {collaborative methodology; embodied labour; hotel housekeeping; sweden; team approach; working participant observation}, abstract = {This paper explores the collaborative methodology of conducting working participant observation in a team setting to study the experiences of hotel housekeepers in Sweden. It aims to refine and extend the method of working participant observation by highlighting the benefits of a team approach to intensive ethnographic fieldwork. Drawing on critiques of 'traditional' geographical methods that rely heavily on interviews, the researchers immersed themselves in the physical labour of housekeeping alongside housekeepers, engaging their own bodies as research instruments. The research team navigated the complexities of embodied labour, reflecting on how their own identities (gender, age, nationality) influenced interactions and observations. The study emphasises the importance of collective reflection and dialogue between researchers, who debriefed each other daily, transforming individual experiences into shared analytical insights. Taking this approach challenges methodological conservatism by integrating feminist and intersectional perspectives and demonstrates how working participant observation can provide deeper understandings of workplace hierarchies, bodily labour, and power dynamics. By focusing on the bodily presence of both researchers and workers, the study highlights the unique insights gained through participatory, team-based ethnographic research in service work.}, issn = {0004-0894} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_drinsvitlana_2025_2, title = {Iterative Demand Optimization Using the Discrete Functional Particle Method}, author = {Drin, Svitlana and Avdieienko, Ivan and Chornei, Ruslan}, year = {2025}, url = {2019884}, language = {eng}, publisher = {Örebro University, School of Business}, keywords = {retail assortment planning; sarimax forecasting; dfpm; inventory efficiency ratio; operational risk optimisation}, abstract = {Modern companies face immense pressure to accelerate and refine decisions related to product assortment due to rapid changes and growing competition in the retail landscape. The volume, velocity, and volatility of business data make intuitive or situational approaches insufficient. Advances in optimization theory and forecasting models enable the design of robust, flexible decision-support systems that bridge the gap between business intuition and data-driven strategy.In retail, risk manifests primarily through operational inefficiencies, such as capital immobilized in unsold inventory and delayed responsiveness to demand changes. This demands a rethinking of risk modeling tailored specifically to the retail domain.At the same time, simplistic forecasting tools often prioritize short-term fluctuations at the expense of strategic seasonal trends, thereby undermining long-term planning. As a result, there is a critical need for integrated models that combine predictive accuracy with optimization under uncertainty. Such models must not only capture patterns in consumer demand but also align with operational constraints to ensure that solutions are implementable in practice.This work proposes a novel, multi-layered framework for assortment optimization that incorporates two key components: SARIMAX-based demand forecasting and the Discrete Functional Particle Method (DFPM) for iterative optimization. Additionally, we introduce a new operational risk measure Inventory Efficiency Ratio (IER) designed to quantify inefficiencies in the retail pipeline.By embedding these techniques into a unified system, we offer a practical solution for improving capital productivity, reducing inventory holding costs, and enhancing responsiveness in assortment planning. The methodology is validated through real-world data and demonstrates substantial performance improvements over standard planning strategies.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_elmazoskairis_2025, title = {"It's about wanting to disappear from the world… " - an interpretative phenomenological analysis on the meaning of music and hearing-related risks}, author = {Elmazoska, Iris and Bengtsson, Staffan and Widén, Stephen}, year = {2025}, journal = {International Journal of Qualitative Studies on Health and Well-being}, volume = {20}, number = {1}, doi = {10.1080/17482631.2025.2480966}, url = {1946348}, language = {eng}, publisher = {Taylor & Francis}, keywords = {adolescent; health promotion; hearing health; meaning; risk awareness; well-being}, abstract = {PURPOSE: To explore the role and meaning of music in adolescents' lives and the adolescents' ways of understanding how music listening can impact hearing-health.METHODS: Open-ended interviews and Interpretative Phenomenological Analysis (IPA). The analysis involves both individual and more generalized investigations based on the contributions from seven participants.FINDINGS: The findings show that music is an integrated and habitual aspect of the adolescents' daily lives, used as a tool for emotion regulation, cognitive enhancement, and creating personal space where one can be free from outside criticisms and distractions. There is a preference for music listening in headphones which creates a more intense and private experience. There are varying levels of awareness of the potential hearing-health risks, but the profound meaning of music for their well-being often overshadows any concerns.CONCLUSIONS: Despite awareness of potential hearing-health risks, the adolescents prioritize the immediate emotional and cognitive benefits of music. Technological advancements and increased social media interactions contribute to a trend towards more personalized music listening. These insights call for more complex intervention strategies and models for health promotion which account for the positive aspects of music listening, instead of merely focusing on the potential risks of loud music.}, issn = {1748-2623} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_larssonhenrik_2025, title = {JCPP Advances in 2025 : A landmark year for growth, quality, and visibility}, author = {Larsson, Henrik}, year = {2025}, journal = {JCPP Advances}, volume = {5}, number = {3}, doi = {10.1002/jcv2.70036}, url = {1992517}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {child and adolescent mental health; impact factor; open science; registered reports}, abstract = {In this editorial, we reflect on a milestone year for JCPP Advances, marked by our first Journal Impact Factor and significant growth in submissions, readership, and citations. We highlight expanded editorial expertise, strengthened commitments to open science, and new initiatives such as Registered Reports. Recent indexing across PsycINFO, PubMed, Scopus, and Web of Science enhances our global visibility. The September 2025 issue exemplifies our dedication to rigorous, impactful research, including evidence syntheses, participatory studies, and methodological innovation. Together, these developments position JCPP Advances as a leading open-access platform advancing child and adolescent mental health research worldwide.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_trbojevifilip_2025, title = {Journalism and Media Freedom in Europe : The fsQCA Approach}, author = {Trbojević, Filip and Berglez, Peter and Vozab, Dina and Ots, Mart and Peruško, Zrinjka}, year = {2025}, journal = {Central European Journal of Communication}, volume = {18}, number = {1(39)}, pages = {29--50}, doi = {10.51480/1899-5101.18.1(39).686}, url = {1928330}, language = {eng}, publisher = {Polish Communication Association}, keywords = {democracy; europe; fsqca; journalism; media freedom}, abstract = {Media freedom is often seen as the main value against which the quality of media systems is judged. While the levels of media freedom in Europe are generally higher than the world average, there are yet significant variations in how certain European countries score on media freedom indices and scales. This paper uses comparative quantitative data and applies the fsQCA method to analyze how macro-, meso-, and micro-levels of journalism as a field relate to different levels of media freedom in Europe. The results suggest that media market structure, journalistic skills, and journalists adhering to the monitorial role of journalism constitute the “core” conditions for the implementation of media freedom.}, issn = {1899-5101}, file = {https://oru.diva-portal.org/smash/get/diva2:1928330/FULLTEXT01.pdf} } @book{ca0f099bbf2a435cee8f97bef5e8cbaa_lunellerika_2025, title = {Juridik - civilrätt, straffrätt, processrätt : Övningsbok}, author = {Lunell, Erika and Lundberg, Konrad and Schüldt, Johan and Rother-Schirren, Theddo and Lagerstedt, Anders and Calleman, Catharina and Persson, Annina H and Radetzki, Marcus and Zila, Josef}, year = {2025}, url = {2023261}, language = {swe}, publisher = {Sanoma Utbildning} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssonmagnus_2025_2, title = {Juristutbildningen i förändring}, author = {Kristoffersson, Magnus}, year = {2025}, pages = {183--199}, url = {2003094}, language = {swe}, publisher = {Iustus förlag}, keywords = {generativ ai; juristutbildning; juristprogrammet; förändring; juristprofessionen} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_korppeter_2025, title = {Justice beyond inclusion : the rightful presence of fat bodies in PE}, author = {Korp, Peter and Quennerstedt, Mikael and Barker, Dean and Johansson, Anna}, year = {2025}, journal = {Sport, Education and Society}, doi = {10.1080/13573322.2025.2515467}, url = {1973123}, language = {eng}, publisher = {Routledge}, keywords = {justice; inclusion; rightful presence; fat bodies; physical education}, abstract = {In this article we problematize equity as inclusion and make a theoretical argument about rightful presence for the 'fat body' in PE. We argue that equity as inclusion is based on a guest/host power dynamic and a 'culture of hospitality' that comes with it. This argument rests on the assumption that inclusion involves a host who represents and safeguards the norms, values, and power structures of the community, welcoming the guest into that community. The host, in this context the institutional (cultural and material) conditions that constitute PE, will control the guests by the rights extended to them, rights that at any moment can be withdrawn. This creates a guest-host power dynamic by which students that do not fit the usual standards of PE will always be 'other', and their rights of presence and participation will always be conditioned.By introducing the concept of rightful presence, we hope to contribute to a debate on the inclusion of the 'fat body' in PE. In developing this argument, we re-analyze Cat Paus & eacute;'s story as described in her article (Paus & eacute;, C. [2019]. (Can we) get together? Fat kids and physical education. Health Education Journal, 78(6), 662-669) and use the situations she describes as a hypothetical example and an illustration to discuss what exclusion, inclusion, and rightful presence, respectively, mean for fat kids in PE.We argue that rightful presence can function as a fruitful and vital concept in research and pedagogical practice in that it encourages scholars and educators to recognize the right of all students to be fully present and to have the same rights as everyone else. It also helps us to ask new questions from a different perspective regarding, in this case, the rightful presence of fat bodies in PE.}, issn = {1357-3322} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lundgrenpia_2025, title = {Juvenile idiopathic arthritis during 20 years in Sweden : Characteristics of children, therapy interventions, occurrence of uveitis and ocular complications}, author = {Lundgren, Pia and Papadopoulou, Maria and Jernkrok, Rebecka and Abedi, Natasha and Karlsson, Eva and Damgaard, Michael and Berg, Stefan and Andersson Grönlund, Marita}, year = {2025}, journal = {Acta Ophthalmologica}, volume = {103}, number = {6}, pages = {652--661}, doi = {10.1111/aos.17466}, url = {1942060}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {ana positivity; immunomodulatory treatment; juvenile idiopathic arthritis; ocular complications; uveitis}, abstract = {PURPOSE: To assess and compare the characteristics, therapy interventions, occurrence of uveitis and ocular complications in children with juvenile idiopathic arthritis (JIA) screened and examined for uveitis in Gothenburg, Sweden, over 20 years. Biological immunomodulatory treatment was increasingly used during the second half of the over 20 years.METHODS: Data were retrospectively collected from children with JIA examined for uveitis at the Queen Silvia Children's Hospital between 2012 and 2021. These data were compared with those from a previously published study of children (the first cohort) screened between 2002 and 2011 in the same setting.RESULTS: The first 10-year cohort (2002-2011) included 299 children, while the second cohort (2012-2021) included 253 children. The median age at JIA diagnosis was 5 years (range: 1-15 years) in both cohorts (p = 0.72), and girls were overrepresented in both groups, 68.9% and 72.7%, respectively (p = 0.32). Oligoarthritis was less frequent in the first cohort than in the second, 57.5% versus 73.9% (p < 0.001). The presence of anti-nuclear antibodies (ANAs) was similar between the cohorts, 57.6% versus 57.9% (p = 0.95). Uveitis occurred less frequently in the first cohort, 10.7% versus 17.0% in the second (p = 0.032). However, uveitis children had (not significantly) more ocular complications in the first cohort, 46.9% versus 34.9% in the second (p = 0.34) and complications were more often affecting both eyes, 73.3% versus 40.0% (p = 0.14). Systemic treatments, particularly biological immunomodulatory therapies, were less commonly used in the first cohort, 24.4% versus 42.7% in the second cohort (p < 0.001).CONCLUSION: Over 20 years, we observed a higher occurrence of uveitis in children with JIA in the second 10-year cohort. However, despite being statistically insignificant, we found fewer ocular complications, and less frequent in both eyes. This may indicate a beneficial effect of the increased use of biological immunomodulatory therapy.}, issn = {1755-375X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_solandertove_2025, title = {Kabukuing Shakespeare : Gender Crossings in Takarazuka's Shakespeare Adaptations}, author = {Solander, Tove}, year = {2025}, journal = {Comparative drama}, volume = {59}, number = {3}, pages = {20--42}, doi = {10.1353/cdr.2025.a969919}, url = {2001363}, language = {eng}, publisher = {Western Michigan University, Department of English}, abstract = {This article discusses gender transformations in the Takarazuka Revue, focusing on two small-theatre Shakespeare adaptations set in kabuki milieus: Epiphany (based on Twelfth Night) and Fuyu monogatari (based on The Winter’s Tale).1 The Takarazuka Revue is a 111-year-old Japanese music-theatre company best known for its all-female casts and otokoyaku (male-role specialists). Shakespeare used boy actors for female roles, including comic cross-dressing roles where heroines appear in male disguise for large portions of the plot. Kabuki, in its current high-cultural manifestation as a traditional Japanese theatre form, employs all-male casts due to a historic ban on female performers. Epiphany and Fuyu monogatari both involve the otokoyaku star crossing back and forth between male and female double roles, and in the case of Epiphany, the “triple drag” role of a female in male disguise. I argue that the Takarazuka Revue queers or rather kabukus Shakespeare by drawing on and meta-theatrically alluding to the Japanese performance tradition of which they are an important part.}, issn = {0010-4078} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_volgstenulrik_2025_3, title = {Kajsa Rootzén and the record review : Solitary listening to die Sache selbst}, author = {Volgsten, Ulrik}, year = {2025}, pages = {257--275}, doi = {10.1007/978-3-031-98261-3_12}, url = {2002194}, language = {eng}, publisher = {Palgrave Macmillan}, keywords = {rootzén; record review; interwar years; new objectivity; phenomenology; dahlhaus; absolute music}, abstract = {This chapter explores the role of record reviews in disseminating the idea of absolute music during the interwar years, focusing on the writings of Swedish critic Kajsa Rootzén. Through her regular reviews in Svenska Dagbladet, Rootzén promoted a mode of solitary listening cantered on the musical work rather than performance or sound quality. The chapter argues that record reviews helped reify the concept of the autonomous musical work, contributing to a new paradigm of listening shaped by repetition, introspection, and conceptual framing. Rootzén’s writing exemplifies a “cordial objectivity” that aligns with broader Neue Sachlichkeit themes while articulating a historically significant shift in musical perception—away from live interpretation and toward the private experience of the recorded work as die Sache selbst.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_norellannika_2025, title = {Kan sömnproblem hos svenska kvinnor i 40-årsåldern förutspå sömnen i 60-årsåldern}, author = {Norell, Annika and Golovchanova, Nadezhda}, year = {2025}, url = {2008463}, language = {swe} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_shihminyang_2025, title = {KEA: Keeping Exploration Alive by Proactively Coordinating Exploration Strategies}, author = {Shih-Min, Yang and Magnusson, Martin and Stork, Johannes Andreas and Stoyanov, Todor}, year = {2025}, volume = {267}, pages = {70927--70942}, url = {2013284}, language = {eng}, keywords = {reinforcement learning; novelty-based exploration; soft actor-critic; sparse reward}, abstract = {Soft Actor-Critic (SAC) has achieved notable success in continuous control tasks but struggles in sparse reward settings, where infrequent rewards make efficient exploration challenging. While novelty-based exploration methods address this issue by encouraging the agent to explore novel states, they are not trivial to apply to SAC. In particular, managing the interaction between novelty-based exploration and SAC’s stochastic policy can lead to inefficient exploration and redundant sample collection. In this paper, we propose KEA (Keeping Exploration Alive) which tackles the inefficiencies in balancing exploration strategies when combining SAC with novelty-based exploration. KEA integrates a novelty-augmented SAC with a standard SAC agent, proactively coordinated via a switching mechanism. This coordination allows the agent to maintain stochasticity in high-novelty regions, enhancing exploration efficiency and reducing repeated sample collection. We first analyze this potential issue in a 2D navigation task, and then evaluate KEA on the DeepSea hard-exploration benchmark as well as sparse reward control tasks from the DeepMind Control Suite. Compared to state-of-the-art novelty-based exploration baselines, our experiments show that KEA significantly improves learning efficiency and robustness in sparse reward setups.}, file = {https://oru.diva-portal.org/smash/get/diva2:2013284/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_boersmakatja_2025, title = {Key aspects concerning the role of emotion in the chronic pain experience}, author = {Boersma, Katja and Flink, Ida Katrina}, year = {2025}, journal = {Current Opinion in Psychology}, volume = {62}, doi = {10.1016/j.copsyc.2025.102000}, url = {1936026}, language = {eng}, publisher = {Elsevier}, keywords = {chronic pain; emotion; fear avoidance; low mood; social emotion}, abstract = {Pain and emotions are inherently connected, and this review presents contemporary findings on the pain-emotion connection. We address in what ways pain and emotions are related as well as how the link may be understood and targeted in treatment. Both pain and negative emotions are essential (and ancient) biological and motivational systems which share protective and regulatory functions. There is a marked co-occurrence between chronic pain and mental health conditions. One way to understand the pain-emotion connection, stressed by recent theoretical models, is that pain and emotions share cognitive and behavioral mechanisms that serve to downregulate these unpleasant inner states. Treatments targeting these shared regulatory mechanisms show promising results, but more research is needed on generalization, implementation and dissemination.}, issn = {2352-250X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_derblomkatharina_2025, title = {Key Aspects of Recovery-Oriented Practice in Caring for People With Mental Ill-Health in General Emergency Departments : A Modified Delphi Study}, author = {Derblom, Katharina and Dahlberg, Karuna and Gabrielsson, Sebastian and Lindgren, Britt-Marie and Molin, Jenny}, year = {2025}, journal = {Journal of Clinical Nursing}, volume = {34}, number = {2}, pages = {565--579}, doi = {10.1111/jocn.17631}, url = {1923372}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {delphi study; delphi technique; emergency department; emergency nursing; mental health recovery; mental illness; mental ill‐health; recovery‐oriented practice}, abstract = {AIM: To identify key aspects of recovery-oriented practice in caring for people with mental ill-health in general emergency departments.DESIGN: A modified Delphi study with three rounds.METHODS: A 24-member expert panel was recruited consisting of people with lived experience of mental ill-health, registered nurses working in emergency care, registered nurses specialised in psychiatric and mental health nursing and mental health recovery researchers. In the initial round, important aspects of recovery-oriented practice were identified through focus group interviews. Thematic analysis generated statements that were then reformulated as a questionnaire for subsequent rounds. The experts rated each statement's perceived importance on a 5-point Likert scale. The consensus level was set at ≥ 80%. Descriptive statistics were used to analyse the data.RESULTS: Consensus was reached on the importance of 39 of 73 statements, with ≥ 80% deemed 'very important' in recovery-oriented practice in general emergency departments.CONCLUSION: The study emphasises the delicate balance between the essential elements of recovery-oriented practice, their practical feasibility and the predominant biomedical perspective in general emergency department care. It proposes strategies to empower nursing staff and managers to adopt recovery-oriented practices that enhance the quality of care for people with mental ill-health. Enabling staff by providing the necessary prerequisites and a care environment that supports reflective practices is crucial. The responsibility for facilitating these changes needs to be a shared commitment between nursing staff and managers.IMPLICATIONS FOR THE PROFESSION AND/OR PATIENT CARE: The identified issues can serve as a framework for interventions, education and training to support the integration of recovery-oriented practice in general emergency care. They can also be used to develop tools for evaluating emergency care environments and promoting alignment with recovery-oriented principles.IMPACT: Problem addressed: People with mental ill-health are at risk of being neglected, judged and dismissed in general emergency department care, creating obstacles to their mental health recovery.MAIN RESULTS: The Delphi study identified 39 key aspects of recovery-oriented practice in general emergency departments, emphasising person-centred, strength-based, collaborative and reflective care.IMPACT: The research seeks to establish a foundation for developing training programmes, education and interventions and for the integration of recovery-oriented practices in general emergency care. It thus has the potential to enhance the quality and equality of care for patients with mental ill-health in emergency care. The impact extends to nursing staff and managers as it seeks to empower them to systematically reflect on and reevaluate established emergency department practices to ensure that every person, irrespective of their health condition, is treated with dignity and respect in emergency department settings.REPORTING METHOD: The CREDES guidance on conducting and reporting Delphi studies.PATIENT OR PUBLIC CONTRIBUTION: The authors have nothing to report.}, issn = {0962-1067} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kuosaannemaria_2025, title = {Kieli ja oikeudenmukaisuus : vertaileva tutkimus Suomessa ja Ruotsissa kirjoitetuista rikostuomioista}, author = {Kuosa, Anne-Maria and Tolvanen, Eveliina and Ervo, Laura and Roos, Linus}, year = {2025}, journal = {Kieli, koulutus ja yhteiskunta}, volume = {16}, number = {7}, url = {2024942}, language = {fin}, publisher = {Kieliverkosto}, abstract = {Svenska kulturfondenin rahoittamassa kaksivuotisessa hankkeessa DOVE: Språket i domar i Sverige och Finland - variation och rättvisa (2025–2027) tarkastellaan käräjäoikeuksissa annettujen ruotsinkielisten rikostuomioiden kielenkäyttöä ja vertaillaan Suomessa ja Ruotsissa ruotsiksi kirjoitettuja tuomioita. Tutkimuksen fokuksessa on, miten tuomioiden kieli eroaa eri maiden välillä ja miten erot voivat vaikuttaa siihen, miten esimerkiksi oikeudenkäynnin osapuolet ja juristit ymmärtävät tuomiot. Hanketta hallinnoi Åbo Akademi ja siihen osallistuu tutkijoita Åbo Akademista, Turun yliopistosta ja Örebron yliopistosta.}, file = {https://oru.diva-portal.org/smash/get/diva2:2024942/FULLTEXT01.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_websternatashaa_2025_1, title = {Kindred}, author = {Webster, Natasha A.}, year = {2025}, pages = {124--124}, url = {1970892}, language = {eng}, publisher = {University of Bristol}, keywords = {cultural geography} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_maenejaron_2025, title = {KLay : Accelerating Arithmetic Circuits for Neurosymbolic AI}, author = {Maene, Jaron and Derkinderen, Vincent and Zuidberg dos Martires, Pedro}, year = {2025}, url = {2021343}, language = {eng}, publisher = {International Conference on Learning Representations, ICLR}, keywords = {neurosymbolic ai; arithmetic circuits; sparse inference}, abstract = {A popular approach to neurosymbolic AI involves mapping logic formulas to arithmetic circuits (computation graphs consisting of sums and products) and passing the outputs of a neural network through these circuits. This approach enforces symbolic constraints onto a neural network in a principled and end-to-end differentiable way. Unfortunately, arithmetic circuits are challenging to run on modern tensor accelerators as they exhibit a high degree of irregular sparsity. To address this limitation, we introduce knowledge layers (KLAY), a new data structure to represent arithmetic circuits that can be efficiently parallelized on GPUs. Moreover, we contribute two algorithms used in the translation of traditional circuit representations to KLAY and a further algorithm that exploits parallelization opportunities during circuit evaluations. We empirically show that KLAY achieves speedups of multiple orders of magnitude over the state of the art, thereby paving the way towards scaling neurosymbolic AI to larger real-world applications.}, file = {https://oru.diva-portal.org/smash/get/diva2:2021343/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tunermerve_2025, title = {Knowing and Finding Your Place : Turkish-Born Women in Sweden Doing and Redoing Gender}, author = {Tunçer, Merve and Alsarve, Jenny and Peterson, Helen}, year = {2025}, journal = {NORA: Nordic Journal of Feminist and Gender Research}, volume = {33}, number = {3}, pages = {263--276}, doi = {10.1080/08038740.2025.2456781}, url = {1933414}, language = {eng}, publisher = {Taylor & Francis}, keywords = {doing gender; negotiation; migrant women; turkey; sweden}, abstract = {This article draws on 20 qualitative interviews with women between 60 and 78 years of age who migrated from Turkey to Sweden some 40 years ago. It focuses on how they understand, reproduce and challenge both pre- and post-migration gender norms. By analysing the narratives of the 20 women, we investigate how they negotiate work, care and housework with their partners over the course of their lives. Furthermore, we examine how the Turkish diaspora in Sweden influences the ways the interviewed women do and redo gender. The findings show that the interviewed women used implicit and explicit negotiations to change, reconstruct and renegotiate gender norms. Doing and redoing gender is a central aspect of these negotiations, since the interviewed women are ambivalent about gender norms. The conclusion is that the women had one foot in traditional gender norms by “knowing their places” but had adapted to more egalitarian norms over the years.}, issn = {0803-8740} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_diwansalwan_2025, title = {Knowledge, attitudes, and practices of transcutaneous electrical nerve stimulation in perioperative care : A Swedish web-based survey}, author = {Diwan, Salwan and Olausson, Alexander and Andréll, Paulin and Wolf, Axel and Jildenstål, Pether}, year = {2025}, journal = {Scandinavian Journal of Pain}, volume = {25}, number = {1}, doi = {10.1515/sjpain-2024-0078}, url = {1941700}, language = {eng}, publisher = {Walter de Gruyter}, keywords = {attitudes; healthcare professionals; knowledge; pain management; practices; transcutaneous electrical nerve stimulation}, abstract = {OBJECTIVES: Transcutaneous electrical nerve stimulation (TENS) is a noninvasive adjunct to multimodal pain management for acute postoperative care across various surgeries. Despite extensive evidence supporting its efficacy, TENS remains underutilized in clinical practice. This study aimed to assess the knowledge, attitudes, and practices of healthcare professionals regarding TENS in perioperative settings to support its integration into routine clinical practice.METHODS: A web-based questionnaire was distributed to anesthesiology department heads at all university hospitals (n = 7) in Sweden and three smaller, randomly selected hospitals across three geographical areas. Department heads forwarded the questionnaire to anesthesiologists, nurse anesthetists, critical care nurses, and registered nurses with basic education working in perioperative settings. The questionnaire included four sections: demographic information, general postoperative phase information, TENS use for postoperative pain relief, and open-ended questions.RESULTS: The survey was sent to 870 respondents, yielding a response rate of 28% (n = 246). Among respondents, 69% reported lacking adequate knowledge to administer TENS, and 79% indicated they did not use TENS in their practice. Furthermore, 45% noted an absence of clinical guidelines supporting the use of TENS in their clinic, while 32% were unsure about the existence of guidelines. However, 60% expressed interest in developing theoretical knowledge and practical skills for TENS application.CONCLUSIONS: This study highlights that substantial knowledge gaps and the lack of clear clinical guidelines limit the use of TENS for acute postoperative pain management. These deficiencies may lead to inadequate pain control, increased opioid use, and opioid-related adverse effects. We recommend that hospital leadership and professional bodies develop and implement comprehensive educational programs and establish clear, evidence-based clinical guidelines for TENS use in postoperative pain management. Addressing these gaps is essential for improving clinical practice and empowering patients through greater involvement and autonomy in pain management strategies.}, issn = {1877-8860} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_svrdveronica_2025, title = {Knowledge production in health social work : an analysis of doctoral dissertations in Sweden}, author = {Svärd, Veronica and Sernbo, Elisabet and Matérne, Marie}, year = {2025}, journal = {Social Work Education}, volume = {44}, number = {6}, pages = {1662--1682}, doi = {10.1080/02615479.2024.2417732}, url = {1913974}, language = {eng}, publisher = {Routledge}, keywords = {healthcare counseling; research method; theory; professionalization; phd student}, abstract = {Health social work is often described as a blurred profession, as a work area based on an interdisciplinary field of science with an unclear knowledge foundation of its own. This study describes and analyses the knowledge production in Swedish doctoral dissertations in health social work, authored by social workers, from 2008 to 2019, and focuses on the differences between dissertations published by faculties of health and those in the social sciences. Descriptive statistical and content analysis was carried out on the 52 dissertations identified. Dissertations in the health sciences were often about specific patient groups within adult somatic care. They predominantly used mixed methods and psychological and psychosocial theories and models. Dissertations in the social sciences more often concerned adults in psychiatric or addiction care and the organization of social work. A majority used qualitative research methods, organization and profession theories, as well as interactionist and critical theories. The differences are discussed as being associated with different research ideals and traditions in the scientific disciplines. The findings raise questions about the core components of health social work and how a knowledge foundation and its development can enhance the professional development of social workers and their contribution to healthcare and patients.}, issn = {0261-5479} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_westerholtmarc_2025, title = {Kokoppor i Sverige – sannolikt en underdiagnostiserad sjukdom : [Cowpox - an underdiagnosed disease in Sweden?]}, author = {Westerholt, Marc and Ocias, Lukas and von Horn, Ellen and Santos-Martin, Dolores and Bläckberg, Jonas and Wilhelmsson, Christina and Lilja, Bamse and Windahl, Ulrika and Sondén, Klara}, year = {2025}, journal = {Läkartidningen}, volume = {122}, number = {32-33}, url = {1990428}, language = {eng}, publisher = {Läkartidningen förlag}, abstract = {Cowpox is an infection caused by the cowpox virus, a zoonotic DNA virus belonging to the genus Orthopoxvirus. The infection presents as a febrile illness with a characteristic eschar-like lesion. Humans are typically infected through contact with rodents or cats who have been in contact with rodents. The diagnosis is made using PCR. In this case series, we present eight cases of cowpox contracted in Sweden.}, issn = {0023-7205} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_sataenhognel_2025, title = {Kommunal riskkommunikation : Professionella utmaningar ochmöjligheter: DURCOM-insikter}, author = {Sataøen, Hogne L.}, year = {2025}, url = {2016800}, language = {swe}, publisher = {Örebro universitet}, keywords = {risk communication; communication professionals; municipalities}, abstract = {Hur kan kommuner, genom sina kommunikatörer, stärka invånarnas förmåga att förstå, förebygga och hantera lokala risker? Detta är kärnfrågan i denna rapport, som sammanfattar ett flertal undersökningar av kommunikatörsprofessionens arbete med riskkommunikation för krisberedskap. Rapporten har tagits fram inom forskningsprojektet DURCOM, finansierat av Myndigheten för samhällsskydd och beredskap (MSB). Författaren, Hogne Lerøy Sataøen, är lektor och docent i medie- och kommunikationsvetenskap vid Örebro universitet.}, file = {https://oru.diva-portal.org/smash/get/diva2:2016800/FULLTEXT01.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_denkthomas_2025_1, title = {Komparativ metod}, author = {Denk, Thomas and Anckar, Carsten}, year = {2025}, pages = {432--452}, url = {2031941}, language = {swe}, publisher = {Studentlitteratur AB} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_denkthomas_2025_2, title = {Komparativ politik : Elva politiska system}, author = {Denk, Thomas and Anckar, Carsten}, year = {2025}, url = {2031948}, language = {swe}, publisher = {Studentlitteratur AB} } @book{ca0f099bbf2a435cee8f97bef5e8cbaa_nergeliusjoakim_2025_2, title = {Komparativ statsrätt}, author = {Nergelius, Joakim}, year = {2025}, url = {2032200}, language = {swe}, publisher = {Juristförlaget, Lund}, keywords = {constitutions; comparisons; electoral system; legislation; fundamental rights; judicial systems}, abstract = {A well-established and quite popular textbook that describes the basic features of the constitutional systems of USA, Germany, France, United Kingdom and the Nordic countries, with some aims of comparison towards the end.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_landqvistmats_2025, title = {Kriskommunikation}, author = {Landqvist, Mats}, year = {2025}, url = {2019795}, language = {swe}, publisher = {Nordisk Retorikkforening}, abstract = {Forskningen om kriskommunikation har traditionellt intresserat sig för hur myndigheter, organisationsledningar och andra i en maktposition har tillämpat strategier för att föra ut budskap om kris och krishantering. Deras strategier syftar till att forma publikens krisuppfattning så att den kan användas som medel för förändring – eller för att undvika förändring. Vilka strategier som används beror på vilken typ av kris som uppstått, allt från en situation som riskerar att drabba ett samhälle på bred front till händelser som hotar att äventyra ryktet hos en organisation eller ett företag. Oavsett vilka avsändarens mål är tycks det finnas en medvetenhet om värdet av att ta fasta på det emotionella engagemang som en kris innebär. Här har särskilt multimodala resurser visat sig viktiga för att skapa ett känslomässigt engagemang, något som är väsentligt för att de önskade effekterna av kommunikationen ska kunna uppnås, som att skapa gemensamma förhållningssätt, lokal beredskap eller en mer fördelaktig syn på en organisation. Allt större insatser krävs dock för att nå ut i det brus som den digitala utvecklingen med sociala medier skapar. Det krävs inte minst stor kännedom om kanalerna hos den som kommunicerar i kris, särskilt om globala klimat-, miljö- och beredskapskriser. Den digitala utvecklingen har samtidigt skapat nya möjligheter för både avsändare och mottagare att vara mer aktiva i den interaktion som kriskommunikation alltmer kommit att bli. På senare tid har forskningen därför kommit att alltmer omfatta mottagarna och deras reaktioner, behov och aktiva roll samt det ledarskap som kan kopplas till det.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_berglezpeter_2025_2, title = {Kritisk diskursanalys}, author = {Berglez, Peter}, year = {2025}, pages = {243--273}, url = {1995803}, language = {swe}, publisher = {Studentlitteratur AB}, keywords = {kritisk diskursanalys} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_jonssonjessica_2025_4, title = {Lagar och vägar : Juristprogrammets 20-årsjubileum vid Örebro universitet}, author = {Jonsson, Jessica and Kristoffersson, Magnus}, year = {2025}, url = {1993571}, language = {swe}, publisher = {Iustus förlag}, abstract = {Juristprogrammet vid Örebro universitet firar 20 år och detta uppmärksammas med en jubileumsantologi!Under dessa två decennier har programmet utvecklats till en dynamisk och betydelsefull utbildningsmiljö, präglad av engagerade lärare, nyfikna och kritiskt tänkande studenter samt ett omgivande samhälle i ständig förändring. Antologin speglar programmets resa, från de ursprungliga idéerna och visionerna till dagens framstående utbildning, med rötterna djupt förankrade i rättsvetenskapen och blicken riktad mot framtidens utmaningar.Titeln Lagar och vägar symboliserar både de stabila fundament som juridiken vilar på och de nya stigar som ständigt öppnas när samhället förändras. Rättsvetenskapen är en hörnsten i universitetets verksamhet och spelar en avgörande roll i samhällsutvecklingen genom att analysera, problematisera och kritiskt granska rättsregler, rättspraxis och rättsliga principer. Som akademisk disciplin står den för kunskap, analys och reflektion – egenskaper som är centrala för såväl forskning som utbildning.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stjohnoliver_2025, title = {Language at the Intersection of Internationalization Policy and Practice in Higher Education}, author = {St John, Oliver and Ålander, Jonas}, year = {2025}, journal = {Bulletin suisse de linguistique appliquée}, volume = {121}, url = {2032326}, language = {eng}, publisher = {Swiss Academy of Humanities and Social Sciences}, keywords = {internationalization; policy; language; higher education; teaching and learning; internationalisation; politique; langue; enseignement supérieur; enseignement et apprentissage}, abstract = {Cet article examine l’interaction complexe entre les politiques d’internationalisation et leur mise en œuvre dans l’enseignement supérieur en mettant en lumière le rôle souvent négligé de la langue. Il soutient que les politiques d’internationalisation ne constituent pas des cadres neutres, mais qu’elles sont façonnées par des dynamiques de pouvoir et les intérêts des parties prenantes, pouvant entraîner la marginalisation de certains groupes. L’étude identifie les défis et les opportunités rencontrés par les étudiants internationaux et doctorants dans le cadre de ces politiques et souligne la nécessité de placer la langue au cœur des démarches pour favoriser l’inclusivité et des expériences éducatives significatives. En adoptant une perspective dynamique de la politique comme processus évolutif influencé par divers acteurs, l’article remet en question les conceptions linéaires traditionnelles de sa mise en œuvre. Il avance que l’engagement réfléchi envers la langue peut combler le fossé entre les directives politiques et les pratiques locales, enrichissant ainsi le paysage éducatif. En s’appuyant sur des données qualitatives recueillies auprès d’enseignants et d’étudiants, cette recherche contribue à une compréhension approfondie de la manière dont la langue façonne les interactions et les identités dans le contexte de l’internationalisation. En définitive, elle appelle à une réévaluation des dimensions linguistiques des politiques d’internationalisation afin de mieux refléter la complexité des pratiques dans l’enseignement supérieur.;This paper examines the complex interplay between internationalization policy and practice in higher education, emphasizing the often-overlooked role of language. It argues that internationalization policies are not neutral frameworks but are influenced by power dynamics and stakeholder interests, which can marginalize certain groups. The study identifies the challenges and opportunities faced by international and PhD students within these policies and highlights the necessity of centering language to promote inclusivity and meaningful educational experiences. By adopting a dynamic perspective towards policy as an evolving process influenced by various actors, the paper critiques traditional linear understandings of policy implementation. It posits that meaningful engagement with language can bridge the gap between policy directives and local practices, thereby enhancing the educational landscape. Drawing on qualitative data from teachers and students, this research contributes to a deeper understanding of how language shapes interactions and identities within the context of internationalization. Ultimately, it calls for a reevaluation of language dimensions in internationalization policies to better reflect the complexities of practice in higher education.}, issn = {1023-2044} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ismailmaryamjaffar_2025, title = {Language Barriers in STEM Education : Comparative insights from Zanzibar and Seychelleson multilingual pedagogies}, author = {Ismail, Maryam Jaffar and Sane, Eliakimu and Deutschmann, Mats and Mwinyi, Maryam Amour and Barrett, Angeline M. and Zelime, Justin}, year = {2025}, journal = {Seychelles Research Journal (SRJ)}, volume = {7}, number = {special issue}, pages = {128--150}, doi = {10.5281/zenodo.16919689}, url = {1998125}, language = {eng}, publisher = {University of Seychelles}, keywords = {language supportive pedagogy; stem subjects; zanzibar; seychelles; language policy; english medium of instruction}, abstract = {Effective teaching and learning, particularly in science, technology, engineering, and mathematics (STEM), require the use of a familiar language to promote student comprehension and engagement. However, in Zanzibar and Seychelles, where English serves as the primary medium of instruction despite being a second language (L2) for most learners, language barriers often hinder student performance. Under the STEM4SUCCESS Zanzibar (S4SZ) Project, launched in 2019, several schools in Zanzibar piloted the Language Supportive Pedagogy (LSP) approach, which acknowledges the role of L2 in the classroom while strategically leveraging students’ first language (L1) to support content acquisition and conceptual understanding. Under the project, 75 STEM educators from 15 schools across Unguja and Pemba were introduced to LSP strategies such as informal L1 discussions, structured L2 transitions, alongside training on digital learning tools (Kio Kits, drones, and projectors). Data was collected in 2024 through an online survey of 20 STEM educators and follow-up telephone interviews. After analysis, classroom observations were conducted to triangulate the data.  Findings revealed that 91% of teachers who had received LSP training, had actively integrated LSP techniques into their lessons. Additionally, 85% of respondents identified English as a major barrier to learning STEM subjects, and a majority of this group thought of LSP as a muarobaini (ultimate cure) for language comprehension challenges in STEM. Moreover, 90% of the teachers reported improved student performance, 85% observed increased student participation, and many teachers noted higher student interest in STEM subjects following the implementation of LSP strategies.The article also discusses comparative aspects and potential lessons to be learnt from the above pilots in other contexts such as Seychelles. In Seychelles’ trilingual education policy, Kreol Seselwa (L1) is used in early primary education, transitioning to English (L2) in Primary 3. As is the case in Zanzibar, this approach creates language barriers in STEM education hindering inclusivity and accessibility. A comparative analysis of the Zanzibar and Seychelles language-in-education policies highlights common challenges and potential benefits in aligning linguistic frameworks with pedagogical practices. This study emphasizes the need for continuous professional development, curriculum alignment with LSP principles, and sustained stakeholder engagement to ensure the scalability and sustainability of LSP.}, file = {https://oru.diva-portal.org/smash/get/diva2:1998125/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_abdeenwaleed_2025, title = {Language Models to Support Multi-Label Classification of Industrial Data}, author = {Abdeen, Waleed and Unterkalmsteiner, Michael and Wnuk, Krzysztof and Ferrari, Alessio and Chatzipetrou, Panagiota}, year = {2025}, pages = {45--55}, doi = {10.1109/SANER64311.2025.00013}, url = {1986449}, language = {eng}, publisher = {IEEE COMPUTER SOC}, keywords = {multi-label; requirements classification; taxonomy; language models}, abstract = {Background: Multi-label requirements classification is an inherently challenging task, especially when dealing with numerous classes at varying levels of abstraction. The task becomes even more difficult when a limited number of requirements is available to train a supervised classifier. Zero-shot learning does not require training data and can potentially address this problem.Objective: This paper investigates the performance of zero-shot classifiers on a multi-label industrial dataset. The study focuses on classifying requirements according to a hierarchical taxonomy designed to support requirements tracing.Method: We compare multiple variants of zero-shot classifiers using different embeddings, including 9 language models (LMs) with a reduced number of parameters (up to 3B), e.g., BERT, and 5 large LMs (LLMs) with a large number of parameters (up to 70B), e.g., Llama. Our ground truth includes 377 requirements and 1968 labels from 6 output spaces. For the evaluation, we adopt traditional metrics, i.e., precision, recall, F-1, and F-beta, as well as a novel label distance metric D-n. This aims to better capture the classification's hierarchical nature and to provide a more nuanced evaluation of how far the results are from the ground truth.Results: 1) The top-performing model on 5 out of 6 output spaces is T5-xl, with maximum F-beta = 0:78 and D-n = 0:04, while BERT base outperformed the other models in one case, with maximum F-beta = 0:83 and D-n = 0:04. 2) LMs with smaller parameter size produce the best classification results compared to LLMs. Thus, addressing the problem in practice is feasible as limited computing power is needed. 3) The model architecture (autoencoding, autoregression, and sentence-to-sentence) significantly affects the classifier's performance.Contribution: We conclude that using zero-shot learning for multi-label requirements classification offers promising results. We also present a novel metric that can be used to select the top-performing model for this problem.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_alifathalla_2025, title = {Laparoscopic ventral hernia repair with intraperitoneal onlay mesh}, author = {Ali, Fathalla}, year = {2025}, url = {1904141}, language = {eng}, publisher = {Örebro University}, keywords = {laparoscopic hernia surgery; ventral hernia; ipom}, abstract = {Advancements in technology and medicine have rendered laparoscopic ventral hernia repair (LVHR) more favourable than open ventral hernia repair (OVHR). Albeit associated with risk of postoperative seroma, LVHR may reduce wound infection rates and hospital stays. However, LVHR requires accurate technique and careful patient selection.Study I was a retrospective study conducted at the Karlskoga Hospital Hernia Centre. From January 2017 to June 2020, 876 ventral hernia operations were performed. We analysed 213 patients who underwent ventral hernia repair with Intraperitoneal Onlay Mesh without defect closure (sIPOM), IPOM with defect closure (IPOM-P), and IPOM with peritoneal bridging (IPOM-pb) and compared the incidence of postoperative seroma, discomfort, recurrence, and complications.Study II was a randomized controlled trial with 112 participants who underwent laparoscopic ventral hernia repair between November 2018 and December 2020. The participants underwent ultrasonography at 1, 3, 6 and 12 months postoperatively. Postoperative seroma, discomfort, and complications following IPOMpb and sIPOM were analysed.Study III was a registry-based study of the impact of COVID-19 on emergency and planned hernia repair procedures, divided into two periods; the pre non COVID-19 Period Januari 2016 - December 2019 as a control group and the COVID-19 Period Januari 2020 to December 2021 as the study group.Study IV was a population-register study based on a retrospective cohort evaluating risk factors for postoperative pain, nausea and vomiting in 4795 patients who underwent ventral hernia repair between 2016 and 2021, with 2409 of them undergoing open ventral hernia repair surgery. Data were assembled from the Swedish ventral hernia register and Swedish perioperative register.Study I showed that the IPOM-pb approach was as safe and feasible as conventional IPOM, requiring no additional effort from the surgeon or staff.Study II showed lower incidence of postoperative seroma and discomfort in IPOM with peritoneal bridging in early-stage follow-ups, with no significant difference in subsequent follow-ups.In study III the pandemic planned surgeries were impacted but the result in this study showed that there was no increase in emergency hernia operations due to delayed planned surgery. Careful observation and caution are crucial during a pandemic.Study IV showed that postoperative pain, nausea and vomiting are more common in women, emergency surgery, younger age patients, and those who had surgery with inhalation anesthesia compared to total intravenous anesthesia.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wassliusjohan_2025, title = {Large regional variation in endovascular thrombectomy rates for acute ischemic stroke in Sweden}, author = {Wassélius, Johan and Hall, Emma and Szolics, Alex and Arnberg, Fabian and Radhi, Hozan and von Euler, Mia and Wester, Per and Ullberg, Teresa and Cronberg, Tobias and Ennab Vogel, Nicklas and Esbjörnsson, Magnus and Jonsson, Fredrik and Andersson, Tommy and Norrving, Bo and Hansen, Björn M.}, year = {2025}, journal = {European Stroke Journal}, volume = {10}, number = {4}, pages = {1320--1327}, doi = {10.1177/23969873251347098}, url = {1971047}, language = {eng}, publisher = {Sage Publications}, keywords = {acute ischemic stroke; effectiveness; endovascular thrombectomy; implementation; key performance indicators (kpis)}, abstract = {INTRODUCTION: Endovascular thrombectomy (EVT) is a significant improvement in the care of acute ischemic stroke (AIS) patients, but only a small portion of patients receive treatment. Our aim was to analyze EVT implementation in Sweden according to a set of key performance indicators (KPIs) for procedural and implementational effectiveness.METHODS: A nationwide prospective registry-based observational study using data from 2018, 2020, and 2022 from the Swedish quality registries for stroke care (Riksstroke and EVAS) and official population statistics. Effectiveness was analyzed using a set of predefined KPIs. To describe procedural and implementation effectiveness in a single comprehensible measure population success rate was derived by multiplying the EVT rate with successful recanalization.RESULTS: Between 2018 and 2022 EVTs in Sweden increased from 874 to 1474 procedures per year. Correspondingly, the EVT rate (EVT/AIS) increased from 4.1% to 7.3%. Implementation was heterogenous with a six-fold difference between the highest and lowest regions. EVT rates were generally highest in regions with comprehensive stroke centers (CSCs). Procedural effectiveness were similar between all CSCs. The population success-rate increased from 3.4% to 6.4% during the period with large differences between CSCs (range 3.4%-12.4%, in 2022). CONCLUSIONS: By including KPIs for procedural and implementational effectiveness, it is possible to evaluate EVT implementation for the entire stroke population, which is the ultimate objective for healthcare. The population success-rate is capturing procedural implementation effectiveness in a single measure comprehensible for all stake holders and facilitate comparisons over time and between regions, even between regions with different stroke incidence.}, issn = {2396-9873} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hellgrenmikko_2025, title = {Large Variation in Adherence to Diagnostic Guidelines in Hypertension Management in Swedish Primary Healthcare}, author = {Hellgren, Mikko and Boström, Kristina Bengtsson and Hedin, Katarina and Jansson, Stefan P. O. and Nilsson, Staffan and Nilsson, Gunnar and Wändell, Per and Wennberg, Patrik}, year = {2025}, journal = {The Journal of Clinical Hypertension}, volume = {27}, number = {6}, doi = {10.1111/jch.70079}, url = {1976568}, language = {eng}, publisher = {Le Jacq Communications, Inc.}, keywords = {blood pressure; guidelines; hypertension; primary care issues}, abstract = {High blood pressure (BP) is a frequent cause for visits to primary healthcare centers (PHCCs) in Sweden. Guidelines on methods for BP measurements for diagnosis of hypertension have recently been updated. We aimed to study adherence to diagnostic guidelines in hypertension management and evaluate whether adherence to guidelines was related to organizational or sociodemographic characteristics. Interviews with representatives from 76 randomly selected PHCCs from eight regions in Sweden were conducted. PHCCs' use of 24-h ambulatory BP monitoring (ABPM), home BP monitoring (HBPM) and BP measurements in both arms for the diagnosis of hypertension were chosen as proxy markers for adherence to diagnostic guidelines. An adherence index was created as a composite score of these diagnostic methods. The proportion of PHCCs stating they "often use" ABPM and HBPM were 13.7% and 16.0%, respectively, and 57.3% stated they performed BP measurements in both arms. Two PHCCs did not use ABPM, HBPM or BP measurements in both arms to diagnose hypertension. None of the organizational or sociodemographic characteristics (number of listed patients, Care Need Index (CNI), geographical location, ownership, investigation primarily led by doctor/nurse, dedicated team management, special training for hypertension and local routines) were associated with the adherence index. This study shows that adherence to diagnostic guidelines vary largely between PHCCs. No organizational characteristic, not even team-based management, was associated with adherence to diagnostic guidelines. The variation raises questions about inequity healthcare and novel strategies that may be needed to improve PHCCs' adherence to diagnostic guidelines in hypertension management. Trial Registration: ClinicalTrials.gov identifier: 263351 [www.researchweb.org].}, issn = {1524-6175} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sunhongyi_2025, title = {Large-scale evidence of a general disease ('d') factor accounting for both mental and physical health disorders in different age groups}, author = {Sun, Hongyi and Carr, Hannah and Garcia-Argibay, Miguel and Cortese, Samuele and Solmi, Marco and Golm, Dennis and Brandt, Valerie}, year = {2025}, journal = {Psychological Medicine}, volume = {55}, doi = {10.1017/S0033291725000522}, url = {1943752}, language = {eng}, publisher = {Cambridge University Press}, keywords = {comorbidity; lifestyle; multi-morbidity; wellbeing; “d” factor}, abstract = {BACKGROUND: It is unknown whether there is a general factor that accounts for the propensity for both physical and mental conditions in different age groups and how it is associated with lifestyle and well-being.METHODS: We analyzed health conditions data from the Millennium Cohort Study (MCS) (age = 17; N = 19,239), the National Child Development Study (NCDS) (age = 44; N = 9293), and the English Longitudinal Study of Ageing (ELSA) (age ≥ 50; N = 7585). The fit of three Confirmatory Factor models was used to select the optimal solution by Comparative Fit Index, Tucker-Lewis Index, and Root Mean Square Error of Approximation. The relationship among d factor, lifestyles, and well-being was further explored.RESULTS: Supporting the existence of the d factor, the bi-factor model showed the best model fit in 17-year-olds (MCS:CFI = 0.97, TFI = 0.96, RMSEA = 0.01), 44-year-olds (NCDS:CFI = 0.96, TFI = 0.95, RMSEA = 0.02), and 50+ year-olds (ELSA:CFI = 0.97, TFI = 0.96, RMSEA = 0.02). The d factor scores significantly correlated with lifestyle and well-being, suggesting healthier lifestyles were associated with a reduced likelihood of physical and mental health comorbidities, which in turn improved well-being.CONCLUSIONS: Contrary to the traditional dichotomy between mental and physical conditions, our study showed a general factor underlying the comorbidity across mental and physical diseases, related to lifestyle and well-being. Our results inform the conceptualization of mental and physical illness as well as future research assessing risk and pathways of disease transmission, intervention, and prevention. Our results also provide a strong rationale for a systematic screening for mental disorders in individuals with physical conditions and vice versa, and for integrated services addressing multimorbidity.}, issn = {0033-2917} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_riknermartinssonamanda_2025, title = {Late adolescents' sense of moral responsibility for climate change : the roles of nature connectedness, parental norms, climate-change worry, distancing, and gender}, author = {Rikner Martinsson, Amanda and Glatz, Terese and Ojala, Maria}, year = {2025}, pages = {296--297}, url = {2001417}, language = {eng}, keywords = {climate change; moral responsibility; adolescents; climate-change worry; nature connectedness}, abstract = {Addressing climate change requires people in the Global North to avoid high-impact behaviors like car use and air travel. Late adolescents, whose engagement in such behaviors may be restricted by age and parental decision-making, are in a crucial stage for developing a sense of moral responsibility for climate change. Understanding why some adolescents cultivate this responsibility is vital, as responsibility relates to both climate engagement and well-being. Therefore, this study aims to identify factors associated with late adolescents' sense of moral responsibility. Nature connectedness, parental social norms, and climate-change worry have been positively linked to pro-environmental behavior in previous research, but their role in relation to moral responsibility for climate change remains less clear. Similarly, the relationship between distancing coping and moral responsibility is yet to be fully understood. In this study we explore ways that these factors are associated with late adolescents´ moral responsibility, and examine whether these relationships differ between girls and boys. In 2023, we surveyed 619 Swedish high school students (ages 16-19), and used structural equation modeling to answer our research questions. Connection to nature, parents' norms, climate-change worry, and distancing coping positively influenced responsibility, with parents' norms having a stronger effect on boys. Climate-change worry partially mediated how parents’ norms and nature connectedness influenced responsibility, with a stronger mediation effect for girls in the latter relationship. Distancing coping did not moderate the relationship between worry and responsibility. Limitations are discussed, and we propose fostering moral responsibility through nature experiences, role modeling, and constructive worry management.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_fjordkvisterika_2025_1, title = {Leading guideline implementation : from the view of first-line nursing and rehabilitation managers in orthopaedic healthcare}, author = {Fjordkvist, Erika}, year = {2025}, url = {1988619}, language = {eng}, publisher = {Örebro University}, keywords = {evidence-based practice; first-line managers; implementation leadership; leadership; orthopaedic healthcare}, abstract = {Background Annually, many persons undergo hip surgery, where urinary retention (UR) is a common complication. A gap exists between clinical practice guidelines (CPGs) and performed care regarding the prevention of UR, highlighting the need for implementation interventions to support uptake of the CPGs. As implementation leaders, first-line managers (FLMs) are key to bridging the knowledge-practice gap and could be included in implementation strategies.Aim To explore guideline implementation in orthopaedic healthcare with a focus on first-line managers’ implementation leadership.Method A cluster-randomised hybrid effectiveness/implementation study involving 17 orthopaedic units performing hip surgery at hospitals located in Sweden. Intervention units formed multi-professional internal facilitating (IF) teams (each including at least one FLM) for a 12-month education and support programme to implement bladder monitoring CPGs. Data was collected via interviews (study I, II, IV), medical record reviews (study III), patient surveys (study III), and registry data (study III), and it was analysed using qualitative content analysis (study I) and thematic analysis (study II), statistical analysis (study III), and realist evaluation (study IV).Results FLMs viewed guideline implementation as a balancing act between organisational structures and unit-level realities (study I). They adapted leadership strategies based on context, often translating guidelines to fit local conditions (study I,II). During COVID-19, implementation was smoother due to unified goals, but it faced barriers such as unclear evidence and rapid changes (study II). The intervention deepened participants’ understanding of both clinical guidelines and implementation science (study IV), though without any statistically significant differences in adherence to bladder monitoring CPGs between intervention and control (study III). Managers played a crucial role in anchoring decisions but stepped back to empower teams (study IV).Conclusion Although FLMs have a clear vision of beneficial leadership in relation to change and use implementation leadership behaviours in CPG implementation, a support and education programme regarding implementation processes could build on their prior knowledge. Still, leadership actions can be influenced by contextual factors, and the FLMs sometimes have to adjust accordingly. Health organisations could support first-line managers in their important role in reinforcing an evidence-based practice by scrutinising the organisational context and creating processes that support implementation leadership.}, file = {https://oru.diva-portal.org/smash/get/diva2:1988619/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_gierasimczuknina_2025, title = {Learning about causation : dynamic epistemic modal logic with causal awareness}, author = {Gierasimczuk, Nina and Grosinger, Hermine J. and Björn Pedersen Thoft, Katrine}, year = {2025}, url = {2023240}, language = {eng}, keywords = {dynamic awareness; dynamic epistemic logic; causality; hybrid causal graphs; causal learning}, abstract = {In this paper, we enrich the existing dynamic epistemic modal logic of causality with dynamic awareness of causal variables. In our setting the agent can become aware of (previously unavailable) causal variables. This approach allows studying important aspects of the development of agents’ knowledge about causal structures. First, we propose the language and discuss some notable validities. We consider scenarios that feature the expert (teacher) who has full knowledge of the causal dependencies, and the layperson (learner) whose knowledge is limited to only the variables she is aware of. Our models and our logic are dynamic: They allow observations by both the expert and the layperson, and they accommodate gaining awareness of causal variables by the layperson. The logic also allows interventions—counterfactual manipulations of values of variables. In the epistemic causal awareness models, the different epistemic levels of the expert and the layperson correspond to implicit and explicit knowledge, respectively. Those different perspectives can also be seen with respect to the causal graphs, in a 2-layer representation (so-called hybrid causal graph) that makes use of ‘shadow’ causal variables. Overall, our framework connects the existing lines of research on dynamic epistemic logic of causality and dynamic awareness with learning and pro-activity in AI.}, file = {https://oru.diva-portal.org/smash/get/diva2:2023240/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_skargrenfredric_2025, title = {Learning by assessing digital government : a case study of the digital index framework}, author = {Skargren, Fredric and Lagsten, Jenny and Hatakka, Mathias and García Ambrosiani, Karin}, year = {2025}, journal = {Transforming Government: People, Process and Policy}, pages = {1--21}, doi = {10.1108/tg-06-2025-0182}, url = {2018004}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {public administration; digital government; benchmark; maturity model; digitalisation; core process}, abstract = {Purpose: This study aims to examine the results and influences of the practical implementation of a Digital Index Framework (DIF) for assessing digital government among government agencies.Design/methodology/approach: The authors use a mixed methods approach in a case study of a project using the DIF and involving two government agencies in Sweden. The analysis focuses on interpreting quantitative results from the DIF and using the schematic theory of evaluation influence to study qualitative data on how the DIF assessment process influences the participants of the project.Findings: The quantitative results show the multifaceted spread of digitalisation among activities for carrying out core processes in government agencies, revealing differences in automation, levels of digital service and the exchange of data. The qualitative analysis shows influences from the DIF in how the participants acquire skills to learn about the development of digitalisation and are primed towards certain cross-government challenges.Originality/value: The study analyses the influence on public sector practitioners from a theoretical framework for assessing digital government by using evaluation research. This entails experiences of a project using a DIF in the context of core processes among public servants in public administration. This is a novel approach to studying practical results and influences in using a framework for assessing digital government; showing how assessment can be used for learning and development of digital government among practitioners.}, issn = {1750-6166}, file = {https://oru.diva-portal.org/smash/get/diva2:2018004/FULLTEXT01.pdf} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_caceresdominguezdavid_2025, title = {Learning Interpretable Robot Policies from Demonstration}, author = {Caceres Dominguez, David}, year = {2025}, url = {2004429}, language = {eng}, publisher = {Örebro University}, abstract = {The vision of robots assisting with our daily life tasks hinges on a fundamental challenge: most robot behaviors require programming by experts, creating a barrier for the many. Learning from Demonstration (LfD) is a family of methods with the potential to democratize robot programming by enabling laypeople to teach robots new skills simply by showing them. However, most LfD methods operate as black-box systems, making it difficult for humans to interpret, adapt, or reuse — key factors for human-robot collaboration and understanding.In this thesis, we instead build upon Behavior Trees (BTs) — a transparent and manageable robot programming framework, whose reactive, modular design and potential for interoperability make them well-suited for constructing sophisticated robot behaviors. To bridge the gap between high-level planning and low-level control, engineers often embed entire behaviors within the BT’s leaf nodes. While functional, this approach encapsulates complete skills, obscuring intermediate subgoals and undermining the transparency and modularity that BTs are meant to provide — ultimately limiting skill reuse and adaptability.The structure of a BT plays a crucial role in effective behavior design. While several approaches have aimed to learn BT structures from demonstrations, they often rely on predefined action sets and state spaces. This necessity for expert-curated inputs constrains the robot’s learning flexibility and reintroduces a degree of expert dependency. Compounding these challenges is a more foundational issue: the BT community lacks universally accepted definitions and rigorous evaluation methods for key properties such as interpretability and modularity. This absence leads to inconsistent claims and makes meaningful comparisons across different studies a significant challenge.To address these gaps, this dissertation proposes a path toward more intuitive and effective robot learning, articulated through three key contributions:First, this thesis formalizes core BT properties for robotics and introduces metrics for the systematic evaluation and comparison of learned policies. Building on this foundation, it investigates how different BT structures impact the interpretability of the control policy, identifying design patterns that best align with human intuition and understanding.Second, this thesis presents a unified control framework that integrates BTs with a high-frequency Stack-of-Tasks (SoT) control strategy, enhancing transparency of BT policies by explicitly revealing the underlying subgoals. This approach allows BT nodes to function as hierarchical, high-frequency control objectives. Moreover, the resulting system achieves rapid reactivity in dynamic environments while supporting the coexistence of heterogeneous controllers and preserving a clean, modular decomposition of complex tasks.Finally, this thesis introduces an end-to-end, label-free LfD pipeline that simultaneously learns the global BT structure and the underlying actions —modeled as Dynamic Movement Primitives—directly from raw demonstration data. By leveraging vision-language models to automatically extract and annotate state representations, this method eliminates the need for handcrafted action sets, predefined state spaces, and time-consuming manual labeling.In summary, this thesis provides a comprehensive framework for learning interpretable, modular, and adaptable robot control policies from demonstration, bridging the gap between transparent policy representation and practical, high-frequency robot control, which marks a significant step toward making robot programming more accessible, robust, and understandable for both experts and non-experts.}, file = {https://oru.diva-portal.org/smash/get/diva2:2004429/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gugliermosimona_2025_1, title = {Learning Lifted Action Models for Planning Domain Acquisition in Noisy Environments}, author = {Gugliermo, Simona and Köckemann, Uwe and Schaffernicht, Erik and Saffiotti, Alessandro}, year = {2025}, journal = {IEEE Access}, volume = {13}, pages = {214452--214466}, doi = {10.1109/ACCESS.2025.3645682}, url = {2029037}, language = {eng}, publisher = {IEEE}, keywords = {planning; noise measurement; noise; data models; accuracy; robustness; robot sensing systems; training; benchmark testing; adaptation models; knowledge acquisition; automated planning; planning domain learning}, abstract = {Automated planning (AI planning) solves complex sequential decision-making problems by searching for action sequences given a domain definition that models the actions a system can take. However, hand-crafting action models for complex problems is often challenging and cumbersome even for experts. To address this, we present Lifted Action Model Learning (LAML), a novel approach for learning planning domains from plan traces obtained by noisy observations of environment states. LAML integrates data lifting, decision-tree learning, and logic induction to derive abstract action models and generate planning domain representations. We evaluate our approach on 23 benchmark domains from the International Planning Competition, comparing its performance to state-of-the-art methods. Our evaluation considers multiple criteria, including domain reconstruction through comparison with reference domains, plan generation feasibility, comparison with historical plans, and plan validation success rate. Experimental results demonstrate that LAML not only reconstructs more accurate action models but also exhibits strong robustness to noise.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_almeidatiago_2025, title = {Learning to Understand and Predict Heterogeneous Trajectory Data}, author = {Almeida, Tiago}, year = {2025}, url = {1985105}, language = {eng}, publisher = {Örebro University}, abstract = {Robots and other intelligent systems operating in complex, dynamic environments must anticipate the current and future intentions, activities, and actions of surrounding agents to navigate efficiently and avoid collisions. Since the agents’ motion trajectories can represent such intentions, trajectory prediction becomes critical in complex, dynamic environments. However, accurately predicting human motion remains challenging due to the multitude of environmental and agent-specific contextual factors that shape trajectory patterns. These include semantic information about the scene, agent roles or tasks, social interactions, physical constraints, and latent behavioral intentions. The complexinter play of these elements leads to heterogeneous trajectories characterized by variability in speed, direction, intent, and interaction patterns. Despite this, many state-of-the-art trajectory prediction models rely on simplifying assumptions, for instance, the absence of stopping behaviors or exclusively social navigation settings (i.e., multiple agents interacting) and training on homogeneous datasets with limited motion diversity. These limitations hinder their performance in more complex, real-world environments.A key but underexplored source of trajectory heterogeneity lies in what we suggest referring to as trajectory classes: groupings of data samples sharing similar characteristics. These may be based on observable semantic attributes (e.g., agent type, activity, role) or data-driven latent features learned from the trajectory data itself. While observable classes can be inferred through visual perception systems, data-driven classes require learning directly from trajectory data. Both types can capture important motion diversity and enhance prediction accuracy when integrated effectively into predictors. Despite their relevance, existing work on trajectory classes lacks both dedicated datasets capturing heterogeneous motion patterns and methodological approaches addressing such heterogeneity. This thesis addresses the described gaps by systematically studying the phenomenon of heterogeneity in human motion, analyzing its sources, proposing methods to collect heterogeneous trajectory data, and incorporate trajectory classes (observable and data-driven) into trajectory prediction frameworks.To answer the first research question – what types of datasets are needed to study trajectory classes and how they should be collected – we introduce THÖR-MAGNI, a large-scale dataset recorded in a mock industrial environment. The dataset captures a wide range of agent activities and roles (e.g., box carriers, groups of people), which can be seen as observable classes, and provides detailed annotations for analyzing these classes in the context of human trajectory prediction. Its complexity and diversity also make it well-suited for learning and analyzing data-driven trajectory classes. We leverage THÖRMAGNI to study the influence of trajectory classes, reflecting underlying human activities or roles in industrial contexts, on trajectory prediction.This thesis primarily investigates both observable and data-driven trajectory classes as mechanisms to improve prediction accuracy. For observable classes, we ask: How can observable classes be leveraged to enhance trajectory prediction? We extend deep learning models to explicitly and efficiently incorporate observable classes. We evaluate their performance on THÖR-MAGNI and a state-of-the-art imbalanced outdoor dataset. Unlike previous approaches, our models do not require class-specific modules, making them inherently more scalable and memory-efficient. We also demonstrate that pattern-based approaches, such as Maps of Dynamics, outperform deep learning models in low-data and class-imbalanced regimes, which are present in robotics, particularly in cold-start settings where robots operate with minimal prior knowledge. However, observable classes can be ambiguous due to their static assignment of a single label to all trajectories of a given agent. This assumption is sometimes disregarded in real-world settings, where a single agent may perform diverse behavioral patterns. To address this limitation, we extend the THÖRMAGNI dataset with fine-grained, frame-level action annotations, resulting in THÖR-MAGNI Act. By leveraging this enriched dataset, we demonstrate that frame-based action labels provide strong contextual cues. When integrated through direct conditioning or multi-task learning frameworks that jointly model trajectories and action sequences, actions help disambiguate static class assumptions and improve prediction accuracy. In particular, augmenting the state representation with frame-level action signals mitigates the limitations of static observable classes by capturing intra-agent behavioral variability.For data-driven classes (those not directly observable), we first investigate how to learn them effectively from trajectory data in the context of prediction tasks. To this end, we propose a novel deep generative framework inspired by self-conditioning techniques from image modeling. Our Self-Conditioned generative model learns trajectory clusters that are intrinsically linked to the generative process itself, allowing these clusters to hold privileged information to guide and enhance the training of downstream predictors. Unlike traditional clustering methods, which often fail to capture minority patterns, our approach more effectively identifies less dominant classes, such as the stopping behavior, improving prediction accuracy across underrepresented trajectory modes. We further integrate these learned classes into a multi-stage prediction framework, where the trajectory classes explicitly condition generative models, leading to more accurate and probabilistically informed predictions.In summary, this thesis provides a comprehensive investigation of the phenomenon of heterogeneity in human trajectory data. It presents methods to analyze natural motion variability, identify meaningful trajectory clusters, quantify their influence on prediction accuracy, and develop mechanisms to integrate this information into deep learning-based predictors. Together, these contributions support more accurate, robust, and context-aware prediction methods for robotics and intelligent systems operating in dynamic human environments.}, file = {https://oru.diva-portal.org/smash/get/diva2:1985105/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kelemenkatalin_2025, title = {Legal Pragmatism : A Comparison with the Nordic Legal Method}, author = {Kelemen, Katalin and Valguarnera, Filippo}, year = {2025}, journal = {The Italian law journal}, volume = {11}, number = {1}, pages = {239--264}, url = {2001243}, language = {eng}, keywords = {pragmatism; nordic legal method; legal history; comparative law; italian law}, abstract = {The article explores the evolution of Nordic legal pragmatism through a comparison withother European legal traditions, particularly that of Italy. The authors analyze the definingcharacteristics and historical development of a pragmatic approach in Nordic law, particularly inSweden, one that prioritizes problem-solving over theoretical abstraction. Tracing Nordic legalpragmatism back to medieval statutes, which were casuistic and practical rather thanconceptually systematic, and the relatively minimal influence of Roman law, the authorshighlight the unique trajectory of Nordic law in contrast to the rest of Europe. Over time, thisapproach fostered an emphasis on social utility and democratic processes, notably expressedin Scandinavian legal realism, which rejected metaphysical legal concepts. The article furtherexamines how pragmatism continues to permeate Swedish law today, evident in legaleducation, legal scholarship and judicial practices, where court judgments emphasize concise,context-sensitive reasoning over conceptual and argumentative diversity. Comparativeanalyses underscore that this pragmatic approach is a hallmark of the Nordic legal tradition,setting it apart from the more theory-driven continental European legal systems.}, issn = {2421-2156}, file = {https://oru.diva-portal.org/smash/get/diva2:2001243/FULLTEXT01.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_rooslinus_2025, title = {Legal Rhetoric in Scandinavia : An Introduction and a Research Overview}, author = {Roos, Linus}, year = {2025}, pages = {213--235}, url = {2006275}, language = {eng}, publisher = {Iustus förlag}, abstract = {This article provides an introduction to the field of legal rhetoric and an overview of Scandinavian research in the area. Legal rhetoric is an interdisciplinary field situated between law and rhetoric, concerned with how language is used to persuade in legal contexts. The article begins by tracing the shared historical roots of law and rhetoric, with a focus on ancient Greece and Rome, where rhetorical skill was integral to both legal and political life. It then identifies several key points of contact between the two disciplines today, including their shared emphasis on persuasion, contextual awareness, and linguistic craftsmanship.The article proceeds to present three main branches of contemporary legal rhetoric: the communicative, which focuses on practical rhetorical tools for lawyers; the methodological, which explores how rhetorical methods can support legal reasoning and analysis; and the philosophical, which investigates foundational questions at the intersection of rhetoric and legal theory.The third section offers an overview of Scandinavian contributions to the field, including anthologies, journal articles, doctoral dissertations, and textbooks. Particular attention is given to works that apply rhetorical theory - such as the theory of topics - to legal argumentation. The section highlights both pioneering publications and more recent developments in Denmark, Norway, and Sweden.In its concluding section, the article reflects on the current state and future of legal rhetoric in Scandinavia. It notes a growing interest among legal professionals and educators, as evidenced by the increasing presence of rhetoric in law school curricula and continuing legal education. At the same time, the article identifies areas - such as legal plain language - where rhetorical perspectives remain underutilized. The article concludes that legal rhetoric in Scandinavia has significant untapped potential, both as a research field and as a resource for legal practice.}, file = {https://oru.diva-portal.org/smash/get/diva2:2006275/FULLTEXT01.pdf} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_ebersmartin_2025_1, title = {Legal Tech Stichwortkommentar}, author = {Ebers, Martin}, year = {2025}, url = {1993864}, language = {ger}, publisher = {Nomos Verlagsgesellschaft} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_mustelljan_2025_1, title = {Legitimating ball games : The recontextualisation of ball games knowledge in Swedish physical education and physical education teacher education}, author = {Mustell, Jan}, year = {2025}, url = {1905739}, language = {eng}, publisher = {Örebro University}, keywords = {ball games; physical education teacher education; content knowledge; pedagogical content knowledge; bernstein; recontextualisation; beginning teachers; transitions; pe practice}, abstract = {This thesis is about ball games as content within physical education teacher education (PETE) and physical education (PE) in a Swedish context. The focus of the study is on how knowledge related to ball games becomes legitimate in PETE, and how this knowledge is transformed and used in pedagogic practice in PE. This thesis consists of four articles investigating these questions in different educational contexts. In Article I, I examine how PE teacher educators define legitimate ball games knowledge in PETE through the lens of Shulman’s theory on teachers’ knowledge. The findings suggest that PE teacher educators define legitimate knowledge as a combination of content knowledge related to participation in sports and pedagogical content knowledge related to learning for all pupils. In Article II-IV the focus is on how knowledge is recontextualised in transitions from PETE to PE and the analysis is done through Bernstein’s theoretical framework. The findings in Article II show that the pre-service teachers’ pedagogic discourse of ball games involved substantial changes and transformations in the transition from university to school placement. These changes can be explained by recontextualising rules that either constrain or enable the use of knowledge. The findings in Article III indicate that beginning teachers had different aims in their teaching, some aimed to develop pupil’s understanding of games while others used ball games as a means to develop movement or cooperative capabilities. The teachers employed different strategies to handle challenges of the cultural influence from competitive sport. The findings of Article IV suggest that beginning teachers consider knowledge from PETE useful and relevant and were able to reproduce this knowledge in PE practice. They were also missing important knowledge, and their teaching was affected by contextual factors. The thesis contributes to existing scholarship with knowledge about the recontextualisation process in which the pedagogic discourse of ball games is constructed within PETE and transformed and reproduced into PE practice.}, file = {https://oru.diva-portal.org/smash/get/diva2:1905739/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_anderssonjonas_2025, title = {Length of stay in the emergency department and its associated input-, throughput-, and output factors at two hospitals in Sweden}, author = {Andersson, Jonas and Kurland, Lisa and Nordgren, Lena and Gusdal, Annelie K. and Cheng, Ivy}, year = {2025}, journal = {BMC Emergency Medicine}, volume = {25}, number = {1}, doi = {10.1186/s12873-025-01283-z}, url = {1986218}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {emergency department; length of stay; explanatory factors; patient flow}, abstract = {Background: Prolonged emergency department length of stay (EDLOS) is a worldwide issue associated with increased mortality, decreased patient satisfaction and poor quality of care. The factors influencing EDLOS have not been comprehensively studied in the context of Swedish EDs. This study's objective is to determine the input-, throughput- and output factors associated with EDLOS, at two urban EDs in Sweden.Methods: Data was collected from two hospitals. All patient visits during the two-year study period were included. Patients who left without being seen by a physician were excluded. The explanatory factors included patient characteristics, medical data, and hospital bed occupancy data. Multi-variable linear regression analysis was used to test the associations between the factors and EDLOS.Results: The top contributors to prolonged EDLOS were diagnostic imaging, which added between 64 and 149 min of EDLOS, diagnostic testing at central laboratory (53-99 min), followed by intra-ED zone transfer (46-94 min). Arriving during crowding or being admitted during high hospital bed occupancy had a significant but relatively small absolute effect on the outcome.Conclusions: Throughput factors had far greater impact on EDLOS than both input- and output factors. Adapting strategies to the structural and procedural characteristics of each setting may enhance the effectiveness of improvement efforts.Clinical trial number: Not applicable.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sderqvistida_2025, title = {Leptospiros – en ofta förbisedd zoonos som kan komma att öka: Två fallbeskrivningar av inhemsk smitta där den ena patienten utvecklade svår sjukdom : [Two cases of indigenous leptospirosis in Sweden]}, author = {Söderqvist, Ida and Ocias, Lukas and Rönnberg, Caroline and Rydgård, Charlotta and Blomqvist, Karin}, year = {2025}, journal = {Läkartidningen}, volume = {122}, url = {2023975}, language = {eng}, publisher = {Läkartidningen förlag}, abstract = {Leptospirosis is a zoonotic infection caused by slow-growing spirochetes of the genus Leptospira. The clinical picture varies from asymptomatic disease and mild flu-like symptoms to severe infection with jaundice, renal failure and pulmonary haemorrhage (Weil's disease). Brown rats are the most important reservoir for human infection, and the animals excrete the bacteria in their urine. Humans are infected either through direct contact with infected animals or indirectly through contaminated fresh water and soil via wounds, damaged skin or mucous membranes. Here we present two cases of indigenous leptospirosis in Sweden, one of whom developed Weil's disease.}, issn = {0023-7205} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_thunbergsara_2025_5, title = {Lessons Learned and Going Forward}, author = {Thunberg, Sara and Arnell, Linda and Källström, Åsa}, year = {2025}, pages = {241--253}, doi = {10.1007/978-3-031-95477-1_12}, url = {2003077}, language = {eng}, publisher = {Palgrave Macmillan}, abstract = {In this final chapter of the book Children in Domestic Violence Shelters: International Perspectives, the authors discuss the similarities between the chapters of the book and what can be learned from them when brought together, allowing for a broader analysis. In addition to this, the UN Convention on the Rights of the Child and Agenda 2023, are central threads throughout this chapter in order to help us understand the importance of involving children in research on domestic violence shelters in relation to their rights, and thus serve as a common base when discussing what needs to be improved regarding children’s situation while living in domestic violence shelters from an international perspective.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hatakkamathias_2025, title = {Lessons Learned from Creating Course Content using Generative AI}, author = {Hatakka, Mathias and Ask, Andreas}, year = {2025}, volume = {24}, pages = {146--153}, url = {2010462}, language = {eng}, publisher = {ACI Academic Conferences International}, keywords = {content creation; generative ai; large language models; chatgpt; course development}, abstract = {The release of generative AI tools such as OpenAI’s ChatGPT has sparked interest in their implications for education. While early discourse emphasized concerns about plagiarism and academic integrity, recent studies have begun to explore the potential of these tools to support teaching and learning. This paper presents a case study on the use of ChatGPT in the redesign of a first-year systems development project course for informatics students. The course required the integration of various course materials, making it a suitable context for evaluating generative AI’s role in course material development. The aim of the study is to present lessons learned from using ChatGPT in the development of course content. Drawing on our practical experience as course designers and instructors, we outline lessons learned from using ChatGPT in the creation of key course elements, including case descriptions, SQL scripts, and requirements specifications. We found that ChatGPT was effective for generating coherent initial drafts of content, but its outputs often required refinement to ensure pedagogical alignment. Challenges included the generation of misleading or irrelevant non-functional requirements and logically flawed code, despite syntactic correctness. Our findings highlight the importance of prompt engineering, critical review, and maintaining a human-in-the-loop approach. We conclude that while ChatGPT can significantly reduce development time for some tasks, it should be used as a complementary tool. This study contributes practical insights to the growing field of AI-assisted education.}, file = {https://oru.diva-portal.org/smash/get/diva2:2010462/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_nauwerckgerolf_2025, title = {Lessons Learned from the Swedish Introduction of HERM}, author = {Nauwerck, Gerolf and Flid Fridell, Johan and Karling, Catrin and Thisell, Henric and Benjaminsson, Julia and Ljungkrona, Ola and Hörnblad, Per}, year = {2025}, volume = {107}, pages = {136--145}, doi = {10.29007/x6hv}, url = {2028714}, language = {eng}, publisher = {EasyChair}, keywords = {enterprise architecture; higher education reference model (herm); localisation}, abstract = {This paper presents experiences from the work undertaken by the Swedish Enterprise Architecture Group in introducing the Higher Education Reference Model into the Swedish context. The paper highlights practical challenges and discusses possible ways forward. The overarching conclusion is that currently adaptation will continue on the institutional, rather than national level. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_palazzoleonardo_2025, title = {Lessons Learnt from the Belimumab Trials in Systemic Lupus Erythematosus}, author = {Palazzo, Leonardo and Tsoi, Alexander and Nikolopoulos, Dionysis and Parodis, Ioannis}, year = {2025}, journal = {International Journal of Molecular Sciences}, volume = {27}, number = {1}, doi = {10.3390/ijms27010037}, url = {2026940}, language = {eng}, publisher = {MDPI}, keywords = {b cell therapies; bliss; belimumab; outcome measures; post hoc analysis; systemic lupus erythematosus}, abstract = {Belimumab, a human monoclonal antibody that works against B-cell activating factor (BAFF), has significantly advanced the management of systemic lupus erythematosus (SLE). Beyond the initial Phase III randomised controlled trials (RCTs) that demonstrated efficacy for belimumab as an add-on to non-biological standard therapy (ST) along with a favourable safety profile, more than 50 post hoc analyses of RCT data have provided additional insights into its clinical utility. These analyses have shown uniformly that belimumab increases the likelihood of achieving meaningful reductions in disease activity, sustained low disease activity, and improved health-related quality of life (HRQoL) outcomes, with more pronounced benefits in serologically active SLE. Studies focusing on organ-specific manifestations revealed that belimumab confers benefits across multiple SLE facets, with prominent effects on musculoskeletal and mucocutaneous symptoms. Along the same lines, post hoc analyses of the BLISS-LN trial demonstrated benefit from belimumab regarding multiple renal outcomes, including reduced renal flare rates, improved glomerular filtration rate, and improved histological findings in repeat kidney biopsies. Long-term extension studies and real-world evidence confirm its durable efficacy and safety, with continued reductions in overall disease activity, glucocorticoid use, and healthcare resource utilisation over several years. By exploring different efficacy endpoints, person-centred outcomes, disease trajectories, and characteristics across organ manifestations, this body of post-marketing evidence has not only enhanced our understanding of belimumab use in SLE but also constitutes a comprehensive framework for future clinical trial design and development of novel therapeutic strategies. The present review summarises key findings of post hoc analyses of RCTs and observational studies of belimumab.}, issn = {1661-6596} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_janssonmarkus_2025, title = {Levator Ani Deficiency and Pelvic Floor Dysfunction 1 Year Postpartum : A Prospective Nested Case-Control Study}, author = {Jansson, Markus and Brismar Wendel, Sophia and Rotstein, Emilia}, year = {2025}, journal = {British Journal of Obstetrics and Gynecology}, volume = {132}, number = {5}, pages = {596--605}, doi = {10.1111/1471-0528.18036}, url = {1919536}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {lad score; levator ani avulsion; levator ani muscle; pelvic floor dysfunction; ultrasound; vaginal birth}, abstract = {OBJECTIVE: First, to assess whether levator ani deficiency (LAD) is associated with pelvic floor dysfunction 1 year postpartum, including urinary, vaginal and bowel symptoms; and second, to explore at what cut-off of LAD score such pelvic floor dysfunction arises. DESIGN: Nested case-control study. SETTING: Örebro University Hospital, Örebro, Sweden.POPULATION OR SAMPLE: Primiparous women 1 year after vaginal birth.METHODS: Three-dimensional endovaginal ultrasound assessment of the levator ani muscle; LAD score based on this ultrasound, and validated questions about pelvic floor dysfunction. Logistic regression models were used.MAIN OUTCOME MEASURES: Symptoms of pelvic floor dysfunction associated with LAD.RESULTS: Altogether 190 women were included, 103 of whom were symptomatic cases and 87 asymptomatic controls. 53% in the case group, and 58% in the control group had a LAD score of 0. A greater LAD score was significantly associated with urinary incontinence (adjusted odds ratio [aOR] 1.11, 95% confidence interval [CI] 1.00-1.22) and vaginal laxity (aOR 1.14, 95% CI 1.03-1.25). The risk of urinary incontinence was increased when the LAD cut-off score was set between ≥ 1 point and ≥ 4 points. The risk of vaginal laxity was increased when the cut-off was set between ≥ 8 and ≥ 14 points.CONCLUSIONS: LAD was associated with both urinary incontinence and vaginal laxity. The risk of urinary incontinence increased already with minor LAD and defects of the most medial levator ani muscle portions normally supporting the midurethra may explain this increase.}, issn = {1470-0328} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_alsosgryagnete_2025, title = {Levelling the field : Towards more inclusive entrepreneurial ecosystems}, author = {Alsos, Gry Agnete and Balkmar, Dag and Breivik-Meyer, Marit and Callerstig, Anne-Charlott and Lindvert, Marta}, year = {2025}, pages = {1--16}, doi = {10.4324/9781003431060-1}, url = {1933968}, language = {eng}, publisher = {Routledge}, keywords = {entrepreneurial ecosystems; gender; entrepreneurship; inclusion}, abstract = {The increased interest in entrepreneurial ecosystems often builds on the underlying assumption that entrepreneurs have equal access to resources, participation, and support. However, women are underrepresented in successful entrepreneurial ecosystems and a persistent gender bias continues to exist. This bias is reflected in assumptions about the typical entrepreneur. It is white American men that spring to mind, portrayed as entrepreneurial superheroes, associated with risk- taking and big money. That they are men is often taken for granted; with successful female entrepreneurs seldom elevated in the same way. This illustrates how entrepreneurship is gendered, with implications for resource access and chances of success. The entrepreneurial ecosystem is not a level playing field.This bbook gives insights on how to remedy gendered challenges that pose problems not only for individuals but also for the entrepreneurial ecosystem. By analysing ways of making entrepreneurial ecosystems more gender- inclusive, the chapters collectively highlight the impact of gender dynamics on entrepreneurial ecosystems and introduce innovative methods for fostering inclusivity. With examples from around the globe, they emphasise the actors and factors that matter for gender- inclusive entrepreneurial ecosystems.The book is interdisciplinary and will appeal to scholars, upper- level students and policymakers interested in entrepreneurship and gender inclusivity.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_zeinermichaela_2025_4, title = {Leveraging mountain pine needles as bioindicators of potentially toxic element contamination in high-elevation ecosystems}, author = {Zeiner, Michaela and Kandler, Wolfgang and Prohaska, Katerina and Krska, Rudolf}, year = {2025}, url = {1940001}, language = {eng}, abstract = {Pine needles from various species have long been utilized as bioindicators of air pollution. The accumulation of major and trace elements in these needles results from both dry and wet deposition of airborne pollutants, as well as the uptake of substances through plant roots. Environmental pollutants can be transported over long distances and reach remote areas. To investigate this, a mountainous region at the confluence of the Lower Inn Valley and Achental in Tyrol, Austria, was selected for sampling. Needles from mountain pines (Pinus mugo) were collected at three different sites at altitudes from 1400 meters to 2000 meters. Sampling covered needles of varying ages—young, one-year-old, two-year-old, and older—from five to ten trees at each site, pooling needles of the same age. Sampling was conducted annually every July from 2018 to 2024. For elemental analysis, dried samples underwent acidic digestion (either microwave assisted or by high pressure asher) followed by quadrupole and high-resolution inductively coupled plasma mass spectrometry (ICP-MS) measurements. The metabolic state of the plant material was monitored in a fast and non-destructive way by Raman spectroscopy providing additional information on the growing conditions of the mountain pines. The highly sensitive differentiation in fingerprint region of the spectra allows the classification of differently grown pine needles. Rigorous quality assurance protocols were implemented to ensure the reliability of the analytical results and their comparability with previously published data. The findings revealed that altitude had a greater effect on the concentrations of macroelements than on potentially toxic elements. Like other pine species, age-related accumulation of certain elements was observed in the needles.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_mantenoglouperiklis_2025, title = {LexiCon : a Benchmark for Planning under Temporal Constraints in Natural Language}, author = {Mantenoglou, Periklis and Hazra, Rishi and Zuidberg dos Martires, Pedro and De Raedt, Luc}, year = {2025}, url = {2023697}, language = {eng}, abstract = {Owing to their reasoning capabilities, large language models (LLMs) have been evaluated on planning tasks described in natural language. However, LLMs have largely been tested on planning domains without constraints. In order to deploy them in real-world settings where adherence to constraints, in particular safety constraints, is critical, we need to evaluate their performance on constrained planning tasks. We introduce LexiCon -- a natural language-based (Lexi) constrained (Con) planning benchmark, consisting of a suite of environments, that can be used to evaluate the planning capabilities of LLMs in a principled fashion. The core idea behind LexiCon is to take existing planning environments and impose temporal constraints on the states. These constrained problems are then translated into natural language and given to an LLM to solve. A key feature of LexiCon is its extensibility. That is, the set of supported environments can be extended with new (unconstrained) environment generators, for which temporal constraints are constructed automatically. This renders LexiCon future-proof: the hardness of the generated planning problems can be increased as the planning capabilities of LLMs improve. Our experiments reveal that the performance of state-of-the-art LLMs, including reasoning models like GPT-5, o3, and R1, deteriorates as the degree of constrainedness of the planning tasks increases. }, file = {https://oru.diva-portal.org/smash/get/diva2:2023697/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hachemhany_2025, title = {Lifelong learning : The red-headed stepchild of Lebanon's National Strategy for Older People}, author = {Hachem, Hany}, year = {2025}, journal = {Studies in the Education of Adults}, volume = {57}, number = {1}, pages = {136--155}, doi = {10.1080/02660830.2023.2269745}, url = {1812975}, language = {eng}, publisher = {Taylor & Francis}, keywords = {lifelong learning; older adult education; positive welfare; lebanon; crisis}, abstract = {Decades of governmental neglect mark the socio-political realities of older people in Lebanon. They endure poverty, illiteracy, ageism, exclusion from healthcare and social security, and are absent from public spaces. Against the backdrop of these realities and Lebanon's ageing population, the Lebanese Ministry of Social Affairs, in collaboration with other stakeholders, recently developed the first-ever National Strategy for Older Persons in Lebanon 2020-2030 (NSOP). This strategy aligns itself with regional and international efforts promoting older people's health and social and economic participation, aims to reduce social disparities, achieve justice and equal opportunities, and promote positive welfare. In light of the paucity of scholarly works examining local policies on the intersection of ageing and adult education policies, this paper proffers a strategy analysis of the NSOP with particular interest in the stature it affords lifelong learning. To that end, two research questions are raised: (1) How does the NSOP imagine the role of lifelong learning in fulfilling its agenda? (2) What disconnects exist between the NSOP's vision of ageing and the imagined role of lifelong learning in realising it? Answers are sought via a double-layered manifest and latent analysis of the NSOP document. Conclusions suggest the NSOP's prescription and description of lifelong learning opportunities, including goals, provision and programming, are shorthanded and ambiguous. The NSOP's 'radical ethos' also staggers on normative ageing ideals enshrined in existing cultural values yet claims to defy them. This policy discussion problematises the ableist and economic function of lifelong learning within the NSOP and, thereafter, the latter's potency in mitigating the doomsday scenario older people in Lebanon endure. Ultimately, action mechanisms on policy, governance, capacity-building and research levels are suggested.}, issn = {0266-0830} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_witteerik_2025_1, title = {Lightweight test-score prediction methods for the Situated Phoneme (SiP) test based on the phoneme-level Speech Intelligibility Index (SIIP), the Phoneme Discriminability Level (PDL) and the Speech Intelligibility Index (SII)}, author = {Witte, Erik}, year = {2025}, journal = {International Journal of Audiology}, pages = {1--14}, doi = {10.1080/14992027.2025.2577702}, url = {2012559}, language = {eng}, publisher = {Taylor & Francis Group}, keywords = {phoneme discriminability level; phoneme-level speech intelligibility index; situated phoneme (sip) test; speech intelligibility index; closed-set testing; speech recognition in noise}, abstract = {OBJECTIVE: To introduce the Phoneme Discriminability Level (PDL) and compare its ability to predict scores on the Situated Phoneme (SiP) test with those of a phoneme-level version of the Speech Intelligibility Index (SIIP) and the original Speech Intelligibility Index (SII).DESIGN: SII, SIIP, and PDL values were calculated for 24,444 SiP-test trials and used to train and evaluate logistic regression models. Models were trained on half of the study sample and statistically evaluated on the other half.STUDY SAMPLE: Seventy-four adult native speakers of Swedish (mean age = 62 years), with hearing ranging from normal to severe loss. All had symmetric hearing without conductive components.RESULTS: Models based on PDL and SIIP showed similar overall predictive power, and both outperformed the SII-based model. SIIP and SII were better at predicting average session scores, whereas PDL was better at predicting scores for individual test words. Adding random intercepts for test words improved the predictive accuracy of the SIIP and PDL models, but only at the level of individual words, not whole sessions.CONCLUSIONS: All investigated models are useful for predicting SiP-test scores. SIIP and PDL appear suitable for optimising SiP-test settings and estimating critical differences.}, issn = {1499-2027} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_filipiakkatarzyna_2025, title = {Likelihood ratio test for covariance matrix under multivariate 𝑡 distribution with uncorrelated observations}, author = {Filipiak, Katarzyna and Klein, Daniel and Mazur, Stepan and Mrowińska, Malwina}, year = {2025}, journal = {Journal of Multivariate Analysis}, volume = {210}, doi = {10.1016/j.jmva.2025.105490}, url = {1989101}, language = {eng}, publisher = {Elsevier}, keywords = {covariance structure; likelihood ratio test; matrix-variate t distribution; maximum likelihood estimators; multivariate t distribution}, abstract = {In this paper, estimators for the unknown parameters under two types of matrix-variate t distributions are determined, and their basic statistical properties, including bias and sufficiency, are investigated. These estimators are then applied to test hypotheses concerning the covariance structure of a multivariate t distribution associated with a collection of uncorrelated, though not necessarily independent, observation vectors, using two types of matrix-variate  distributions. A likelihood ratio test is proposed, and its distributional properties under the null hypothesis are examined, assuming either a fully specified covariance matrix or one specified up to a constant. Furthermore, it is demonstrated that the asymptotic distribution for the type I matrix-variate t distribution under both hypotheses coincides with that under the normality assumption. Finally, for testing a fully specified covariance matrix, the asymptotic distribution of the likelihood ratio test statistic is determined.}, issn = {0047-259X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_greavessusan_2025, title = {Linking the Mini-Assisting Hand Assessment and the Assisting Hand Assessment in children with unilateral cerebral palsy}, author = {Greaves, Susan and Holmefur, Marie and Bard-Pondarre, Rachel and Krumlinde-Sundholm, Lena}, year = {2025}, journal = {Developmental Medicine & Child Neurology}, volume = {67}, number = {10}, pages = {1309--1314}, doi = {10.1111/dmcn.16311}, url = {1947105}, language = {eng}, publisher = {Mac Keith Press}, abstract = {AIM: To determine the relationship between the Assisting Hand Assessment (AHA), valid for children aged 18 months to 18 years with unilateral cerebral palsy (CP), and the Mini-Assisting Hand Assessment (Mini-AHA), valid for children aged 8 months to 18 months, so results from the two tests can be compared.METHOD: This psychometric study used AHA data from 157 children and Mini-AHA data from 86 children. In addition, data from children who had undertaken both the AHA and Mini-AHA assessments within a fixed time frame were sought. A Rasch measurement model analysis was conducted using a concurrent test linking technique when both tests have been undertaken by the same (common) persons.RESULTS: Data from 23 children who completed both assessments were added to previous AHA and Mini-AHA data. Using the combined data, the common person test linking Rasch analysis showed the AHA and Mini-AHA test results were not equivalent and a conversion table of Mini-AHA units to AHA units was needed.INTERPRETATION: Information from the conversion table will allow clinicians and researchers to measure changes in use of the affected hand during bimanual performance in children with unilateral CP from 8 months to 18 years.}, issn = {0012-1622} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_erlingedavid_2025, title = {Lipoprotein(a), Cholesterol, Triglyceride Levels, and Vulnerable Coronary Plaques : A PROSPECT II Substudy}, author = {Erlinge, David and Tsimikas, Sotirios and Maeng, Michael and Maehara, Akiko and Larsen, Alf Inge and Engstrøm, Thomas and Kjøller-Hansen, Lars and Matsumura, Mitsuaki and Ben-Yehuda, Ori and Bøtker, Hans Erik and Fröbert, Ole and Persson, Jonas and Wiseth, Rune and Jensen, Lisette O. and Nordrehaug, Jan E. and Trovik, Thor and Jensen, Ulf and Bleie, Øyvind and Omerovic, Elmir and James, Stefan K. and Rylance, Rebecca and Sharma, Tania and Ali, Ziad A. and Stone, Gregg W.}, year = {2025}, journal = {Journal of the American College of Cardiology}, volume = {85}, number = {21}, pages = {2011--2024}, doi = {10.1016/j.jacc.2025.04.013}, url = {1969969}, language = {eng}, publisher = {Elsevier}, keywords = {ldl; lipoprotein(a); myocardial infarction; vulnerable plaque}, abstract = {BACKGROUND: Although lipoprotein(a) (Lp[a]) has been associated with acute myocardial infarction (MI), the relationship between Lp(a) and the presence of high-risk "vulnerable" coronary plaques has not been studied. OBJECTIVES: The aim of this study was to investigate whether specific lipoproteins are associated with pancoronary plaque volume and lipid deposition vs the development of non-flow-limiting high-risk vulnerable plaques.METHODS: In PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree) II, 3-vessel coronary artery imaging was performed with a combined near-infrared spectroscopy and intravascular ultrasound catheter after treatment of all flow-limiting lesions in patients with recent MI. The relationships of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (HDL-C), HDL-C, Lp(a), and triglycerides to pancoronary plaque volume, pancoronary lipid core burden index (LCBI), and the presence of focal vulnerable plaques (plaque burden ≥70% and maximum LCBI over any 4-mm segment ≥324.7) were assessed in 865 patients.RESULTS: By multivariable analysis, TC, LDL-C, and non-HDL-C (but not Lp[a]) were associated with pancoronary plaque volume and pancoronary LCBI (P < 0.01 for all), but not with the presence of vulnerable plaque. Conversely, Lp(a) (but not TC, LDL-C, or non-HDL-C) was associated with the presence of focal vulnerable plaques (P = 0.01).CONCLUSIONS: In PROSPECT II, elevated TC, LDL-C, and non-HDL-C were strongly associated with pancoronary atherosclerosis and lipid deposition, whereas elevated Lp(a) was strongly associated with the presence of focal vulnerable plaques. These findings may explain the association between high Lp(a) levels and future MI and suggest a unique role for Lp(a) role in atherosclerosis progression and plaque vulnerability. (PROSPECT II & PROSPECT ABSORB-An Integrated Natural History Study and Randomized Trial; NCT02171065).}, issn = {0735-1097} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_castroalvesvictor_2025, title = {Liquid and gas-chromatography-mass spectrometry methods for exposome analysis}, author = {Castro Alves, Victor and Nguyen, Anh Hoang and Barbosa, João Marcos G. and Oresic, Matej and Hyötyläinen, Tuulia}, year = {2025}, journal = {Journal of Chromatography A}, volume = {1744}, doi = {10.1016/j.chroma.2025.465728}, url = {1935121}, language = {eng}, publisher = {Elsevier}, keywords = {chromatography; environmental pollutants; exposome; mass spectrometry; metabolomics}, abstract = {Mass spectrometry-based methods have become fundamental to exposome research, providing the capability to explore a broad spectrum of chemical exposures. Liquid and gas chromatography coupled with low/high-resolution mass spectrometry (MS) are among the most frequently employed platforms due to their sensitivity and accuracy. However, these approaches present challenges, such as the inherent complexity of MS data and the expertise of biologists, chemists, clinicians, and data analysts to integrate and interpret MS data with other datasets effectively. The "omics" era advances rapidly, driven by developments of AI-based algorithms and an increase in accessible data; nevertheless, further efforts are necessary to ensure that exposomics outputs are comparable and reproducible, thus enhancing research findings. This review outlines the principles of MS-based methods for the exposome analytical pipeline, from sample collection to data analysis. We summarize and review both standard and cutting-edge strategies in exposome research, covering sample preparation, focusing on MS-based platforms, data acquisition strategies, and data annotation. The ultimate goal of this review is to highlight applications that enable the simultaneous analysis of endogenous metabolites and xenobiotics, which can help enhance our understanding of the impact of human exposure on health and disease and support personalized healthcare.}, issn = {0021-9673} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_melanderida_2025, title = {Listbruk i egenremisser : en sortering och medikalisering?}, author = {Melander, Ida}, year = {2025}, pages = {268--279}, url = {1993854}, language = {swe}, publisher = {Örebro universitet} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_meehanadriandavid_2025, title = {Lithium-Induced Hyperparathyroidism (LHPT)}, author = {Meehan, Adrian David and Wallin, Göran}, year = {2025}, pages = {433--446}, doi = {10.1007/978-3-031-81813-4_38}, url = {2029733}, language = {eng}, publisher = {Springer Nature}, keywords = {hypercalcemia; hyperparathyroidism; lithium; multiple-gland disease; parathyroidectomy; single-gland disease}, abstract = {Lithium is one of the oldest known metals. It has multiple functions, but it was not until the 1940s that it was successfully used in the treatment of severe manic depression by John Cade, now regarded as the father of modern psychopharmacology. Side effects in the form of electrolyte imbalance, in particular hypercalcemia, were later suggested in 1973. Since then, over 300 surgical cases are reported in English literature regarding the treatment of lithium-induced hyperparathyroidism (LHPT). Whether LHPT is to be considered as a separate endocrinopathy is largely unknown and still debated. We elaborate on these issues, including potential mechanisms instigating LHPT, its biochemical profile and potential strategies for optimal medical and surgical management.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_dahlizabelaa_2025_4, title = {Litterära historiseringar av Förintelsen}, author = {Dahl, Izabela A.}, year = {2025}, pages = {349--371}, url = {1953744}, language = {swe}, publisher = {Natur och kultur}, keywords = {förintelsens litteratur; förintelsen; sverige; metoder; litteratur; historisering}, abstract = {Kapitlet diskuterar temat Förintelsen i relation till litterära texter. Det tar upp frågor om objektivitet och etik i samband med Förintelselitteratur, inklusive konstnärliga aspekter kontra historisk autenticitet. Diskussionen berör även vad fiktion kan tillföra som historievetenskapliga översiktstexter inte kan erbjuda när det kommer till att skildra Förintelsen.Med avstamp i Ruth Klügers metod för kritisk analys av litterära verk refereras här ett antal texter som behandlar Shoah, den stora judiska katastrofen på 1900-talet. Vissa av dessa texter är välkända inom ämnet, medan andra har blivit betydelsefulla inom den skandinaviska och svenska kontexten.Kapitlet tar upp och exemplifierar de utmaningar som både läsare och lärare ställs inför när de försöker förstå och tala om traumatiska upplevelser, särskilt när det inte finns några etablerade metoder för berättandet och man behöver utforska nya tillvägagångssätt.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_anderzencarlssonagneta_2025_1, title = {Lived experiences of parents with deafblindness - not 'a walk in the park'}, author = {Anderzen-Carlsson, Agneta and Huus, Karina and Björk, Maria and Warnicke, Camilla and Wahlqvist, Moa}, year = {2025}, journal = {Disability and Rehabilitation}, volume = {47}, number = {16}, pages = {4244--4255}, doi = {10.1080/09638288.2024.2443566}, url = {1925696}, language = {eng}, publisher = {Taylor & Francis}, keywords = {deafblindness; disability research; family life; lived experience; needs; parenting}, abstract = {PURPOSE: To describe how parents with deafblindness experience parenting and family life.MATERIALS AND METHODS: This a qualitative interview study. Fourteen parents with deafblindness were interviewed. Most were mothers (n = 10), with ages ranging between 33 and 57 years (mean 46 years). Interviews were transcribed, and the analysis was done using inductive qualitative content analysis. RESULTS: The analysis resulted in the overarching theme, 'Living family life as a parent with deafblindness is not a walk in the park, but it is rewarding', and three subthemes, 'Being a competent parent despite having deafblindness', 'Needing support to fulfil my parental obligations' and 'Parenting is a struggle due to my deafblindness'. The results encompass many experiences and feelings and illustrate the complex reality of these parents in their parental role and family life.CONCLUSION: The parents expressed their joy in being parents, but these feelings were intertwined with negative aspects of being unable to take on the desired responsibility or not receiving the necessary support. When requested, tailored support should be offered from social services, health care and rehabilitation services in order for parents with deafblindness to take on the parental responsibility they want and to be able to actively participate in family life.}, issn = {0963-8288} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lasyteimante_2025, title = {Liver steatosis prevalence in primary sclerosing cholangitis}, author = {Lasyte, Imante and Hov, Johannes R. and Lindström, Lina and Ingre, Michael and Rorsman, Fredrik and Nyhlin, Nils and Molinaro, Antonio and Kechagias, Stergios and Bergquist, Annika}, year = {2025}, journal = {Journal of Hepatology}, volume = {82}, number = {Suppl. 1}, pages = {S321--S322}, url = {1963320}, language = {eng}, publisher = {Elsevier}, abstract = {Background and aims: The rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), driven by the obesitepidemic, has made its co-occurrence with other primary livediseases increasingly common. Primary sclerosing cholangitis (PSCis a rare immune-mediated cholestatic liver disease, and there is a gain research aiming to evaluate the prevalence and impact of livesteatosis in PSC. We aimed to evaluate the prevalence of liver steatosiin patients with PSC using controlled attenuation parameter (CAPmeasurements, acquired during transient elastography.Method: Patients with PSC were enrolled from an ongoing multi-center phase III study of simvastatin (PiSCATIN). Clinical, laboratoryliver MRI data, CAP and liver stiffness measurement (LSM) value(Fibroscan, Echosens, Paris, France) were collected at baseline. Livesteatosis was defined by a median CAP value of ≥254 dB/m, as validated by Steinman et al. in their study on CAP accuracy for detecting steatosis in autoimmune liver diseases. Baseline characteristics were compared between non-steatotic and steatotic patient groups using frequencies or median and IQR. The association between CAP values and these parameters was assessed with uni- and multivariable linear regression models. A 2-tail significance level of p < 0.05 was chosen.Results: A total of 220 patients with valid CAP values were included, 153 (69.5%) males. The median CAP was 227 dB/m (IQR 80) with a point prevalence of liver steatosis (CAP ≥254 dB/m) of 29% (95% CI 23–35). Patients’ age, sex, PSC type or duration did not differ significantly between steatotic and non-steatotic groups. In both groups the prevalence of IBD was 80%, IBD duration did not differ significantly. Median body mass index (BMI) was 24.1 kg/m² (IQR 5.3) in the non-steatotic group and 27.8 kg/m² (IQR 5.8) in the steatotic group, with fewer lean individuals (BMI <25) in the steatotic group (17% vs. 55%, p < 0.05). Cholesterol and triglyceride levels were higher ( p < 0.05) in steatotic group, with medians of 5.5 mmol/L (IQR 1.25) and 1.2 mmol/L (IQR 0.7), compared to 5 mmol/L (IQR 1.6) and 0.9 mmol/L (IQR 0.45) in the non-steatotic group. The median LSM value was 6.9 kPa (IQR 5.3), with no significant association between CAP and LSM values ( p > 0.05). Multivariable linear regression showed BMI, triglycerides, and diabetes independently associated with CAP ( p < 0.05), but no significant association was found between CAP and MRI findings of advanced liver disease (e.g., liver deformity, ascites, spleen enlargement, and varices).Conclusion: Although the potential importance of steatosis in PSC prognosis is yet to be determined, the prevalence of liver steatosis in patients with PSC was within the range expected in the general population. Higher BMI and plasma triglyceride levels, but not a more advanced disease stage, are associated significantly with higher CAPvalues.}, issn = {0168-8278} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_norlanderlouise_2025, title = {Living with pectus excavatum : Experiences and health-related quality of life before and after minimal invasive repair}, author = {Norlander, Louise}, year = {2025}, url = {1930429}, language = {eng}, publisher = {Örebro University}, keywords = {experiences; funnel chest; minimal invasive repair; mixedmethods; nuss; pectus excavatum; psychometrics; qualitative content analysis; quality of life}, abstract = {Although pectus excavatum (PE), the most common congenital chest wall deformity, can cause both physical and psychosocial suffering, minimal invasive repair for PE (MIRPE) can improve outcomes regarding health-related quality of life (HRQoL). However, MIRPE has not been evaluated in a Swedish context and lacks qualitative explorations. This thesis examines the HRQoL and experiences of living with PE before and after MIRPE. Study I translated, culturally adapted, and evaluated the psychometrical properties of the Nuss Questionnaire modified for Adults (NQ-mA) and the Single Step Questionnaire. The Swedish version of NQmAwas validated for assessment after MIRPE. Study II evaluated HRQoL in patients who had undergone MIRPE. The results show men have better HRQoL than women. Older participants and those who still had their bar in place had significantly lower HRQoL. Study III described the experiences of living with PE before MIRPE. The qualitative findings show that PE was a heavy burden, causing both physical and social limitations in everyday life. Although the participants experienced that healthcare providers have limited knowledge about PE, MIRPE instilled hope for a better life after surgery. Study IV, a mixed-methods design, aimed to gain a comprehensive understanding of experienced HRQoL after MIRPE. Participants experienced a strengthened sense of self and an increased freedom in life after MIRPE. For some of the participants, however, surgery did not solve all their problems. In conclusion, a Swedish HRQoL measurement for individuals with PE is valid for use after MIRPE. PE is a heavy burden and healthcare providers need to increase their knowledge about PE. Although HRQoL improves after MIRPE, careful preoperative information must be provided for individuals to make informed decisions.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_anderssonwatzanna_2025, title = {Living with progressive neurological disease and breathing difficulties}, author = {Andersson-Watz, Anna and Bergdahl, Elisabeth and Eriksson Crommert, Martin and Nygren-Bonnier, Malin and Svantesson, Mia}, year = {2025}, journal = {Annals of palliative medicine}, volume = {14}, number = {1}, pages = {67--78}, doi = {10.21037/apm-24-139}, url = {1938708}, language = {eng}, publisher = {AME Publishing Company}, keywords = {neuromuscular disease; mechanical insufflation-exsufflation (mi-e); progressive neurological disease; qualitative}, abstract = {BACKGROUND: Persons diagnosed with progressive neurological disease who experience breathing difficulties and impaired cough function, are a vulnerable group. Some are in the late end-of-life stage, and providing the right kind of support is a challenge. There is a need to address the broader experiences of living with a progressive neurological disease including breathing difficulties and impaired cough function. Therefore, the aim was to explore persons' experiences of living with progressive neurological disease and breathing difficulties.METHODS: We used qualitative content analysis, drawing on 15 interviews with 10 persons with progressive neurological disease.RESULTS: Living with progressive neurological disease and breathing difficulties can be understood as a reconciliation with a difficult life, a powerlessness in the struggle against deterioration and a fluctuation between feelings of trust and mistrust. An acceptance of the severity was described and a strive to make the best of life. The ongoing struggle against deterioration brought feelings of uncertainty, fear, and powerlessness, impacting the entire life. Feeling safe, supported, and receiving symptom-relief care highlighted the importance of being listened to, feeling goodwill and caring presence of others. Feeling badly treated and, not respected as a whole and competent person, were expressed as being devastating and a sense of being abandoned by health care.CONCLUSIONS: Our study emphasizes the importance of providing palliative person-centered care for this group. This implies a holistic, dignity-preserving, empathetic and compassionate care including symptom relief early in the illness trajectory.}, issn = {2224-5820} } @mastersthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_lushnikovaalexandra_2025_1, title = {Local and Systemic Immunomodulatory Mediators in Patients with Microscopic Colitis}, author = {Lushnikova, Alexandra}, year = {2025}, url = {1962956}, language = {eng}, publisher = {Örebro University}, keywords = {microscopic colitis; ulcerative colitis; cd8+ t lymphocytes; colorectal cancer; colonic biopsies; immune surveillance}, abstract = {Microscopic colitis (MC), divided into lymphocytic colitis (LC) and collagenous colitis (CC), is an inflammatory bowel condition with an unknown cause that commonly afflicts older women. Unlike ulcerative colitis (UC) patients, MC patients have a decreased risk of developing colorectal cancer. The adaptive immune response in MC patients was investigated to elucidate the role of CD8+ T cells.Luminex analyses were performed in patients with MC, UC and controls. Paper I measured immunomodulatory molecules such as immune checkpoints in serum and colonic biopsies. Paper II examined mediators produced by CD8+ T cells in addition to other chemokines and cytokines in colonic biopsies from MC and UC patients.In paper I, soluble levels of IDO, PD-1, TIM-3, 4-1BB, CD27 and CD80 were decreased in MC compared to controls, whereas IL-2R∝ and 4-1BBL were increased. In biopsies, increased levels of CTLA-4, PD-1, PD-L1, PD-L2, 4-1BB, APRIL, BAFF and IL-2R∝ were detected whereas levels of TIM-3 and CD27 were decreased in MC patients compared to controls.In paper II, colonic levels of granzyme B and CCL5 were higher in CC than UC, CCL4 and CD163 were increased at similar levels in CC and UC, and MMP-1, MMP-3 and TNF-RII levels were increased in CC and UC compared to controls. MC and UC patients had increased levels of 4-1BB and perforin. Gp130 and IL-6R∝ were decreased in MC compared to controls.These studies suggest the presence of an active immunological responsein MC involving CD8+ T cells and different disease mechanismsin MC and UC.}, file = {https://oru.diva-portal.org/smash/get/diva2:1962956/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_simonal_2025, title = {LOCATING NUMBERS ON THE NUMBER LINE : AN EYETRACKING STUDY WITH FIRST GRADERS WITH AND WITHOUT RISK OF DEVELOPING MATHEMATICAL DIFFICULTIES}, author = {Simon, A.L. and Geimer, L. and Baumanns, L. and Pitta-Pantazi, D. and Christou, C. and Lilienthal, Achim and Schindler, M.}, year = {2025}, volume = {2}, pages = {283--290}, url = {2029129}, language = {eng}, publisher = {Psychology of Mathematics Education (PME)}, abstract = {The number line (NL) is an important tool in mathematics education. Previous research has found that fifth graders with mathematical difficulties show difficulties in locating numbers on marked NLs, which are common in mathematics education. The aim of this eye-tracking study is to investigate if these difficulties are already evident among students at the beginning of primary school. We investigated if first graders at risk of developing mathematical difficulties (RMD) (n=23) and first graders not at risk of developing such difficulties (n=100) differ in locating numbers on a marked NL from 0–20 – in success rates, response times, and strategies. We found that RMD students made more errors. While we did not find differences in response times, students’ strategy use differed in that RMD students used less efficient strategies. } } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_olssonjan_2025, title = {Lojalitetens gränser och möjligheter}, author = {Olsson, Jan}, year = {2025}, pages = {90--106}, url = {1988710}, language = {swe}, publisher = {Sveriges Kommuner och Regioner} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_eklunda_2025, title = {Longitudinal and cross-sectional analysis of perfluoroalkyl substances and kidney function}, author = {Eklund, A. and Taj, Tahir and Dunder, L. and Lind, P. M. and Lind, L. and Salihovic, Samira}, year = {2025}, journal = {Journal of Exposure Science and Environmental Epidemiology}, volume = {35}, number = {6}, pages = {1041--1049}, doi = {10.1038/s41370-025-00785-z}, url = {1970264}, language = {eng}, publisher = {Nature Publishing Group}, keywords = {chemical exposure; glomerular filtration rate; kidney function; mixed models; pfas; perfluorinated chemicals}, abstract = {BACKGROUND: Perfluoroalkyl substances (PFAS) constitute a diverse group of chemical compounds used in various consumer products. While the associations between PFAS and certain adverse human health effects are well-documented, their impact on kidney function remains less known.OBJECTIVE: The main aim of this study is to investigate the relationship between PFAS levels and kidney function (estimated glomerular filtration rate [eGFR]) utilizing a longitudinal design.METHODS: The population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study included 997 individuals at baseline (all aged 70 years, 50% females). Follow-up investigations were performed at 75 and 80 years of age. Seven major PFAS were determined in plasma using ultra-high performance liquid chromatography-mass spectrometry. Longitudinal and cross-sectional associations between PFAS and eGFR were analyzed using linear regression and mixed effects models following adjustment for sex, HDL and LDL-cholesterol, triglycerides, glucose, BMI, statin use and smoking.RESULTS: Longitudinal models demonstrated statistically significant positive associations between perfluoroundecanoic acid (PFUnDA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA)and eGFR (all P < 0.001). The associations between linear perfluorooctane sulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) followed a similar trend. In contrast, an inverse relationship between perfluoroheptanoic acid (PFHpA) and perfluorooctanesulfonamide (PFOSA) with eGFR was observed. The findings were largely corroborated by cross-sectional analyses.IMPACT STATEMENT: This longitudinal study found that changes in certain PFAS concentrations were positively associated with the change in kidney function, though the direction of association varied across PFAS. These findings were further supported by cross-sectional analysis. The complexity of associations remains incompletely understood as some PFAS showed positive associations while others were inverse. Further longitudinal studies with repeated measures are needed to better elucidate the relationship between PFAS exposure and kidney function.}, issn = {1559-0631} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_daskalakiskosmas_2025, title = {Longitudinal Changes in Ki-67 Indices in Small-Intestinal Neuroendocrine Tumours and Their Impact on Survival}, author = {Daskalakis, Kosmas and Tsoli, Marina and Wedin, Maria and Kos-Kudla, Beata and Kogut, Angelika and Srirajaskanthan, Raj and Clement, Dominique S. V. M. and Giovos, Georgios and Weickert, Martin O. and Kaltsas, Gregory}, year = {2025}, journal = {Neuroendocrinology}, volume = {115}, number = {5}, pages = {402--410}, doi = {10.1159/000541101}, url = {1901118}, language = {eng}, publisher = {S. Karger}, keywords = {grade progression; ki-67 proliferation index; small intestinal neuroendocrine tumours}, abstract = {INTRODUCTION: The purpose of this study was to evaluate longitudinal changes in Ki-67 indices of SI-NETs and assess the impact of these in overall survival (OS).METHODS: We screened 551 patients with SI-NETs diagnosed from 1993, through 2021, identified using the SI-NET databases from five European referral centres. Only patients with well-differentiated tumours and available baseline tumour samples and follow-up re-biopsies were included. For tumour grading, apart from 2017 WHO classification system, we applied a recently proposed SI-NET site-specific modified histopathological grading system with Ki-67 cut-offs of 5 and 10%. Uni- and multivariable regression analyses were used to determine whether there was a difference between OS in SI-NET patients stratified by increment of Ki-67 indices over time and/or progression to a higher grade.RESULTS: We included 45 patients. Median Ki-67 index at SI-NET diagnosis was 2% (range: 0.5-15%). Thirty-three patients had Ki-67 indices &lt;5% (70.2%), 6 had Ki-67: 5-10% (12.8%), and 8 had Ki-67 ≥10% (17%). Mean time to re-biopsy was 48.8 months (SD: ±162.5). At re-biopsy, the median change in Ki-67 index (absolute value; follow-up minus time of diagnosis) was 1% (range: -10 to +38%). An increase in Ki-67 occurred in 20 patients (42.6%); in 14 patients, the change in Ki-67 resulted in progression to higher tumour grade following the modified grading system. Patients with an increment in Ki-67 ≥1% had a median OS of 32.9 months versus 80.5 months in patients without (HR = 5.6, 95% CI: 1.42-22.02; p = 0.014). When applying the novel modified histopathological grading system for SI-NETs, patients with grade progression had a median OS of 32.9 months versus 53.7 months in those without (HR = 4.61, 95% CI: 1.22-13.54; p = 0.022). At multivariable analysis, grade progression was confirmed as an independent predictor for death (HR = 7.2, 95% CI: 1.58-32.82; p = 0.011).CONCLUSIONS: Metachronous increment in Ki-67 indices and related grade progression over time following a site-specific modified histopathological grading system with Ki-67 cut-offs of 5 and 10% is observed in approximately 1/3 of SI-NETs subjected to re-biopsy and it is associated with worse survival outcomes.}, issn = {0028-3835} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bruinsmara_2025, title = {Long-term clinical outcomes after Lyme neuroborreliosis in children}, author = {Bruinsma, R. A. and Skogman, Barbro Hedin and van Hensbroek, M. Boele and Vermeeren, Y. M. and Hovius, J. W. and Zomer, T. P.}, year = {2025}, journal = {BMC Pediatrics}, volume = {25}, number = {1}, doi = {10.1186/s12887-025-05782-7}, url = {1981404}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {borrelia; children; facial nerve palsy; follow-up; idiopathic facial nerve palsy; lyme neuroborreliosis}, abstract = {BACKGROUND: Lyme neuroborreliosis (LNB) is a tick-borne infection caused by spirochetes of the Borrelia burgdorferi sensu lato complex. Facial nerve palsy and subacute meningitis are the most prevalent neurological manifestations. Long-term prognosis is a major concern of many parents. These concerns relate to persisting neurological deficiencies as well as long-term non-specific symptoms such as fatigue. The aim of this study is to determine long-term outcome in pediatric LNB by using patient-reported outcome measures (PROMs) of facial impairment and self-reported fatigue and to compare these outcomes between children with LNB and idiopathic facial nerve palsy (IFP).METHODS: A long-term follow-up study was performed including all children (< 18 years) who visited the departments of pediatrics, neurology, or otorhinolaryngology of Gelre hospitals Apeldoorn and Zutphen between 1 January 2010 and 31 December 2023 with the diagnosis LNB or IFP. After consent, children and/or parents (or guardians) were invited to complete an electronic questionnaire, including the Facial Clinimetric Evaluation (FaCE) scale and the Checklist Individual Strength (CIS).RESULTS: During the study period, 105 children were identified with facial nerve palsy and 4 with LNB with only headache. These 4 patients with meningitis but without facial nerve palsy were not included in further analyses. Seven children were lost to follow up. In total, 102 children were invited to complete the questionnaires, of which 84 responded (82%) after a median follow-up period of 93.5 months after the acute facial nerve palsy. The median total score of the FaCE scale was 99.2 (IQR 89.2-100) in children with LNB and 98.3 (IQR 93.3-100) in children with IFP and results did not differ between groups (p = 0.787). There were no significant differences between patients with LNB and IFP in the CIS total score (median (IQR), respectively 42.0 (26.3-69.5) versus 48.0 (40.3-60.5) (p = 0.301)).CONCLUSIONS: This long-term follow-up study adds new data on self/parent reported disease specific outcomes in children with facial nerve palsy from two important patient groups (LNB and IFP). Both facial impairment and fatigue were uncommon and did not differ between LNB and IFP patients at long-term follow-up.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wewermadsdamsgaard_2025, title = {Long-term disease course of Crohn's disease in a prospective European population-based inception cohort : an Epi-IBD cohort study}, author = {Wewer, Mads Damsgaard and Lophaven, Søren and Lakatos, Peter L. and Gonczi, Lorant and Salupere, Riina and Linda Kievit, Hendrika Adriana and Nielsen, Kári Rubek and Midjord, Jóngerð and Domislovic, Viktor and Krznarić, Željko and Pedersen, Natalia and Kjeldsen, Jens and Halfvarson, Jonas and Sebastian, Shaji and Goldis, Adrian and Arebi, Naila and Oksanen, Pia and Neumann, Anders and Andersen, Vibeke and Katsanos, Konstantinos H. and Koukoudis, Anastasios and Turcan, Svetlana and Ellul, Pierre and Kupcinskas, Juozas and Kiudelis, Gediminas and Fumery, Mathurin and Kaimakliotis, Ioannis P. and D'Inca, Renata and Lombardini, Silvia and Hernandez, Vicent and Fernandez, Alberto and Langholz, Ebbe and Munkholm, Pia and Burisch, Johan}, year = {2025}, journal = {Clinical Gastroenterology and Hepatology}, doi = {10.1016/j.cgh.2025.10.022}, url = {2012145}, language = {eng}, publisher = {Elsevier}, keywords = {crohn’s disease}, abstract = {BACKGROUND AND AIM: The Epi-IBD cohort is a population-based inception cohort of patients with inflammatory bowel disease from 22 European centres. The aim was to assess the 10-year disease course of patients with Crohn's disease (CD) and how regional differences in treatment strategies impact the disease course.METHODS: Patients were followed prospectively from the time of diagnosis, with uniform collection data. Associations between outcomes and covariates were analysed by multivariable Cox regressions in a propensity score-matched sub-population to address time to first intestinal resection.RESULTS: A total of 547 CD patients were recruited (Eastern Europe:139 (25.4%), Western Europe:408 (74.6%)). 10-year cumulative rate of advanced therapy use was higher in Western (42%) compared to Eastern Europe (27%) (p<0.05). The median period until initiation of advanced treatment was shorter in Western Europe, 10 vs 46 months (p<0.001). Despite these differences, the need for surgery remained comparable in Eastern and Western Europe, with a 10-year rate of 24% (p=0.9). A similar comparability was observed for disease progression from uncomplicated disease to complicated disease (10-year rate:20%, p=0.07) and hospitalisation (10-year rate:41%, p=0.5). Use of advanced therapy, stricturing or penetrating disease at diagnosis, progression of disease behaviour, and former smoking were all associated with an increased risk of intestinal resection (all p<0.05).CONCLUSIONS: Despite earlier and more frequent use of advanced therapies in Western Europe, no differences in disease outcomes were observed between Western and Eastern European patients. Ten years after diagnosis, one-in-five patients with uncomplicated disease at diagnosis progressed to complicated disease and one-in-four needed surgery.}, issn = {1542-3565} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wewermadsdamsgaard_2025_1, title = {Long-term disease course of ulcerative colitis in a prospective European population-based inception cohort : an Epi-IBD cohort study}, author = {Wewer, Mads Damsgaard and Lophaven, Søren and Lakatos, Peter L. and Gonczi, Lorant and Salupere, Riina and Kievit, Hendrika Adriana Linda and Nielsen, Kári Rubek and Midjord, Jóngerð and Domislovic, Viktor and Krznarić, Željko and Pedersen, Natalia and Kjeldsen, Jens and Halfvarson, Jonas and Sebastian, Shaji and Goldis, Adrian and Arebi, Naila and Oksanen, Pia and Neumann, Anders and Andersen, Vibeke and Katsanos, Konstantinos H. and Koukoudis, Anastasios and Turcan, Svetlana and Ellul, Pierre and Kupcinskas, Juozas and Kiudelis, Gediminas and Fumery, Mathurin and Kaimakliotis, Ioannis P. and D'Inca, Renata and Lombardini, Silvia and Hernandez, Vicent and Fernandez, Alberto and Langholz, Ebbe and Munkholm, Pia and Burisch, Johan}, year = {2025}, journal = {Journal of Crohn's & Colitis}, volume = {19}, number = {6}, doi = {10.1093/ecco-jcc/jjaf089}, url = {1970218}, language = {eng}, publisher = {Oxford University Press}, keywords = {colectomy; ulcerative colitis}, abstract = {BACKGROUND AND AIMS: The Epi-IBD cohort is a population-based inception cohort of patients with inflammatory bowel disease from 22 European centres. The aim was to assess the 10-year disease course of patients with ulcerative colitis (UC) across Europe.METHODS: Patients were followed prospectively from the time of diagnosis in 2010 and 2011, with uniform collection of data to end of 2020. Associations between covariates and colectomy, progression to extensive disease and hospitalisation were analysed separately by multivariable Cox regression analyses in a propensity score-matched sub-population to address regional differences.RESULTS: A total of 873 UC patients were recruited (Eastern Europe: 196 (22.4%), Western Europe: 677 (77.5%)). The 10-year crude rate for the use of advanced therapy was comparable in Eastern (13%) and in Western Europe (16%) (p>0.9), and the median time from diagnosis until initiation of advanced treatment was similar, at three years. The need for colectomy remained comparable in Eastern and Western Europe, with a 10-year crude rate of 4% and 6% (Cox:p=0.6), respectively. Likewise, disease progression to extensive disease (10-year rate: 17%, Cox:p=0.06) and hospitalisation (10-year rate: 23%, Cox:p=0.2) were comparable across Europe. The use of advanced therapy, and the early use of corticosteroids, were both associated with an increased risk of colectomy (Cox:both p<0.05).CONCLUSIONS: While the introduction of advanced therapies for UC has transformed the therapeutic landscape, their impact on colectomy rates, disease progression, and hospitalisations remains modest. Our findings highlight the need for continued innovation in UC treatment and the importance of individualised and targeted care to achieve optimal long-term outcomes.}, issn = {1873-9946} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mejaddamala_2025, title = {Long-term effects of gastric bypass and sleeve gastrectomy in type 2 diabetes : a matched retrospective cohort study from Sweden}, author = {Mejaddam, Ala and Carlsen, Hanne K. and Larsson, Ingrid and Eeg-Olofsson, Katarina and Lugner, Moa and Ottosson, Johan and Stenberg, Erik and Höskuldsdóttir, Gudrun and Eliasson, Björn}, year = {2025}, journal = {The Lancet Regional Health: Europe}, volume = {58}, doi = {10.1016/j.lanepe.2025.101430}, url = {1997365}, language = {eng}, publisher = {Elsevier}, keywords = {alcohol use disorder; all-cause mortality; anxiety; bariatric surgery; bowel obstruction; cancer; cardiovascular death; cardiovascular disease; chronic kidney disease; depression; diabetes mellitus; drug use disorder; gastric bypass; gastrointestinal leakage; gastrointestinal reflux disease; gastrointestinal ulceration; heart failure; ischaemic heart disease; long-term complications; malabsorption; micronutrient deficiency; obesity; overall mortality; overweight; post-operative complications; psychiatric disorders; roux-en-y gastric bypass; sleeve gastrectomy; type 2 diabetes mellitus; weight-loss; weight-loss treatment; wound complications}, abstract = {BACKGROUND: Long-term data on the efficacy and safety of Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) in people with type 2 diabetes mellitus (T2DM) are still limited. Using a matched cohort design, we aimed to evaluate the long-term effects of RYGB and SG on individuals with T2DM, focussing on obesity- and surgery-related outcomes over a follow-up period of up to 14 years.METHODS: A nationwide, matched, longitudinal study was conducted using data from the Swedish National Diabetes Register (NDR) and the Swedish Obesity Surgery Registry (SOReg). Between 2007 and 2020, all individuals with T2DM who underwent primary surgery (RYGB = 7294 and SG = 1105) were identified through SOReg and matched by age, sex, and BMI to a control group of individuals with T2DM from NDR who had not undergone surgery (n = 8399). Data on all-cause mortality and obesity- and surgery-related outcomes after RYGB and SG were retrieved from national registers with almost complete coverage. Risks were expressed as incidence rates per 10,000 person-years and analysed using adjusted Cox regression models, which included duration of diabetes, yielding adjusted hazard ratios (HR) with 95% confidence intervals (CI).FINDINGS: During follow-up, the percentage total weight loss and reductions in HbA1c levels were significantly greater after RYGB and SG than in unexposed individuals (%TWL: RYGB 23·2 vs. 3·6 and SG 17·1 vs. 3·1 at two years, smd > 0·1) and (mean HbA1c: RYGB 46 (SD 14) vs. 58 (SD 17) and SG 46 (SD 13) vs. 55 (SD 15) at two years, smd > 0·1). RYGB was associated with sustainable reductions in all-cause mortality (adjusted HR of 0·62 (95% CI [0·51-0·71])) and obesity-related comorbidities, with risks as much as 45% lower compared to unexposed individuals (p < 0·001). However, individuals after RYGB face as much as a twofold increased risk of malabsorption and micronutrient deficiency (adjusted HR of 2·00 (95% CI [1·76-2·28])) and alcohol use disorder (adjusted HR of 2·82 (95% CI [2·37-3·36])), p < 0·001. The risk of other psychiatric disorders, such as depression (adjusted HR of 1·28 (95% CI [1·14-1·43])), and surgical complications, such as bowel obstruction (adjusted HR of 3·96 (95% CI [3·15-4·98])), was also higher after RYGB (p < 0·001). In contrast, the SG cohort showed no significant effects on obesity-related conditions and risk of surgical complications, despite similar weight reduction in both surgery groups.INTERPRETATION: The study highlights the advantages and limitations of RYGB and SG, providing insights to guide an individualised approach. The limited efficacy of SG in lowering obesity-related disease risks should be a key consideration when selecting individuals with T2DM for surgery. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zhuyufei_2025_1, title = {Long-Term Human Motion Prediction Using Spatio-Temporal Maps of Dynamics}, author = {Zhu, Yufei and Rudenko, Andrey and Kucner, Tomasz P. and Lilienthal, Achim J. and Magnusson, Martin}, year = {2025}, journal = {IEEE Robotics and Automation Letters}, volume = {10}, number = {11}, pages = {12229--12236}, doi = {10.1109/LRA.2025.3619831}, url = {2013627}, language = {eng}, publisher = {IEEE}, keywords = {trajectory; dynamics; hidden markov models; predictive models; robots; prediction algorithms; accuracy; vehicle dynamics; tracking; pedestrians; human detection and tracking; human and humanoid motion analysis and synthesis; probability and statistical methods; human-aware motion planning}, abstract = {Long-term human motion prediction (LHMP) is important for the safe and efficient operation of autonomous robots and vehicles in environments shared with humans. Accurate predictions are important for applications including motion planning, tracking, human-robot interaction, and safety monitoring. In this letter, we exploit Maps of Dynamics (MoDs), which encode spatial or spatio-temporal motion patterns as environment features, to achieve LHMP for horizons of up to 60 seconds. We propose an MoD-informed LHMP framework that supports various types of MoDs and includes a ranking method to output the most likely predicted trajectory, improving practical utility in robotics. Further, a time-conditioned MoD is introduced to capture motion patterns that vary across different times of day. We evaluate MoD-LHMP instantiated with three types of MoDs. Experiments on two real-world datasets show that MoD-informed method outperforms learning-based ones, with up to 50% improvement in average displacement error, and the time-conditioned variant achieves the highest accuracy overall.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bezabheyaredh_2025, title = {Long-term per-and polyfluoroalkyl substances (PFAS) exposure causes selective changes in the rhizosphere bacterial community}, author = {Bezabhe, Yared H. and Nassazzi, Winnie and Tapase, Savita and Ahrens, Lutz and Jass, Jana}, year = {2025}, journal = {Agriculture, Ecosystems & Environment. Applied Soil Ecology}, volume = {216}, doi = {10.1016/j.apsoil.2025.106561}, url = {2014162}, language = {eng}, publisher = {Elsevier}, keywords = {pfas; soil microbial community; phytoremediation; pfas-associated biomarker taxa; plant-microbe interactions}, abstract = {Per-and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants, yet their impact on soil microbial diversity, function, and plant-microbe interactions remain poorly understood. This study investigates the effects of short-term (3 months, high concentration) and long-term (>30 years, low concentration) PFAS exposure on rhizosphere bacterial communities, incorporating plant interactions and functional gene profiling. Using 16S rRNA amplicon sequencing, selective microbial shifts were observed, where Firmicutes, Bacteroidetes and Gemmatimonadetes were enriched, while Actinobacteria and Acidobacteria declined in PFAS-contaminated soils. LEfSe biomarker analysis identified 33 genera including Nitrosospira, Nakamurella, Gemmatimonas, Nitrosomonas, Nordella and Pseudonocardia present in long-term exposed soils but were absent in short-term exposure, highlighting adaptive microbial responses over time. Functional predictions revealed enrichment of genes associated with xenobiotic degradation, lipid metabolism, and redox processes, inferring possible microbial metabolic adaptations to PFAS. Plant-specific effects further shaped microbial communities, with willow promoting Bacteroidetes and poplar reducing Actinobacteria, emphasizing their potential role in phytoremediation strategies. Overall, this study provides insight into potential microbial biomarkers and functional redundancy associated with PFAS exposure and features the long-term impact of PFAS on rhizoshpere microbial ecosystems, informing strategies for bioremediation and ecosystem recovery.}, issn = {0929-1393} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_granvikchristoffer_2025, title = {Long-term Physical Capacity Following COVID-19 : A Prospective, Three-Year Study}, author = {Granvik, Christoffer and Persson, Ida-Lisa and Barros, Guilherme W. F. and Ahlm, Clas and Forsell, Mattias N. E. and Tevell, Staffan and Sundh, Josefin and Blomberg, Anders and Lind, Alicia and Cajander, Sara and Normark, Johan}, year = {2025}, journal = {Journal of Infection}, volume = {91}, number = {4}, doi = {10.1016/j.jinf.2025.106614}, url = {1997765}, language = {eng}, publisher = {Elsevier}, keywords = {breathlessness; covid-19; diffusing capacity of the lung; physical capacity}, abstract = {OBJECTIVES: COVID-19 impacts physical and respiratory health, and the clinical presentation ranges from asymptomatic cases to severe infections requiring hospitalisation. While the long-term effects on lung function and physical capacity are well-documented in moderate to severe cases, the long-term outcome for individuals with mild COVID-19 remains poorly understood. This study investigates the long-term recovery of physical capacity and breathlessness among both hospitalised and non-hospitalised individuals.METHODS: This prospective cohort study enrolled individuals with confirmed SARS-CoV-2 infection between April 2020 and May 2021 through the CoVUm-study. Participants underwent assessments of lung function at 3-6 months after infection and attended follow-ups up to three years post-infection. Physical capacity was evaluated at follow-ups, using the one-minute sit-to-stand test and the modified Medical Research Council scale to assess breathlessness.RESULTS: The cohort included 291 participants, 35% of whom were hospitalised during SARS-CoV-2 infection. At the 3-year follow-up, 191 participants completed the physical capacity test and 179 had an assessment of breathlessness. Physical capacity improved significantly in the total cohort up to two years post-infection where improvement plateaued. Hospitalisation and impaired diffusing capacity were significantly associated with reduced physical capacity (beta -6.4, p < 0.001; beta -8.9, p < 0.001, respectively) and breathlessness (beta 3.9, p < 0.001; beta 1.6, p = 0.012, respectively). While non-hospitalised participants demonstrated improvements in physical capacity for up to two years, improvement for hospitalised individuals plateaued by six months.CONCLUSION: Hospitalisation and impaired diffusing capacity are strong independent predictors of reduced physical capacity and persistent breathlessness up to three years post-infection. Non-hospitalised individuals also experience long-term reductions in physical capacity, underscoring the need for targeted rehabilitation strategies.}, issn = {0163-4453} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_katonaandrs_2025, title = {Long-term prognosis after coronary bifurcation PCI-A nationwide observational study}, author = {Katona, András and von Koch, Sacharias and Andell, Pontus and Völz, Sebastian and Omerovic, Elmir and Fröbert, Ole and Mohammad, Moman A.}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {3}, doi = {10.1371/journal.pone.0317628}, url = {1948216}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {BACKGROUND: Long-term outcomes of percutaneous coronary intervention (PCI) for bifurcation lesions are underexplored. We investigated long-term PCI outcomes for proximal LAD bifurcation lesions involving D1.METHODS: Using Swedish registries, we included all patients undergoing LAD-D1 bifurcation PCI with drug-eluting stents between 2010 and 2020. Patients were stratified into two groups: simple PCI and complex PCI. The simple PCI group included those with stents in the proximal LAD only, while complex PCI involved the kissing balloon technique or a 2-stent approach for the proximal LAD and D1. A multivariable Cox regression model was used to estimate event rates of major adverse clinical events (MACE), defined as all-cause death or a new myocardial infarction. Secondary outcomes included target segment revascularization or coronary artery by-pass graft surgery (CABG) and definite stent thrombosis.RESULTS: A total of 6,796 individuals were analyzed: 2,007 underwent complex PCI and 4,789 simple PCI. Baseline characteristics were comparable between groups. The complex PCI group was slightly younger, more often male, and more frequently taking statins. At 1-year, MACE rates were lower in the complex PCI group (6.2% vs 7.9%; adjusted HR 0.74, 95% CI 0.59-0.93, p = 0.010). The result was driven by lower all-cause mortality (3.6% vs. 5.0%; adjusted HR 0.73, 95% CI 0.54-0.98, p = 0.036). No significant differences in myocardial infarction, target segment revascularization, CABG, stent thrombosis, stroke, or bleeding were observed between groups, persisting at five years.CONCLUSION: Over a five-year period, complex PCI of LAD/D1 bifurcation lesions was associated with better outcome than simple PCI in a routine clinical setting.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ferrarigabriele_2025, title = {Long-term results of percutaneous coronary intervention in no-touch vein grafts are significantly better than in conventional vein grafts}, author = {Ferrari, Gabriele and Geijer, Håkan and Cao, Yang and Graf, Ulf and Bojö, Leif and Carlsson, Roland and Souza, Domingos and Samano, Ninos}, year = {2025}, journal = {Perfusion}, volume = {40}, number = {1}, pages = {211--220}, doi = {10.1177/02676591241230012}, url = {1832817}, language = {eng}, publisher = {Sage Publications}, keywords = {coronary artery bypass graft; major adverse cardiac events; no-touch; percutaneous coronary intervention; saphenous vein; stent}, abstract = {INTRODUCTION: Conventional vein grafts have a high risk of thrombosis and early atherosclerosis. Percutaneous coronary intervention (PCI) in conventional vein grafts is associated with a higher incidence of late adverse cardiac events. The aim of this study was to evaluate the long-term results after PCI in saphenous vein grafts (SVG) harvested with the no-touch technique compared to the conventional technique.METHODS: This was a single-center, retrospective, cohort study, based on data from the Swedeheart register. The inclusion criterion was individuals who underwent CABG using different vein graft techniques between January 1992 and July 2020, and who required a PCI in SVGs between January 2006 and July 2020. The primary end point was long-term in-stent restenosis. The secondary endpoints were long-term major adverse cardiac events (MACE) and 1-year re-hospitalization rates. The associations between the graft types and the endpoints were evaluated using the Fine and Gray competing-risk regression analysis.RESULTS: The study included 346 individuals (67 no-touch, 279 conventional). The mean clinical follow-up time was 6.4 years with a standard deviation of 3.7 years. The long-term in-stent restenosis rate for the no-touch grafts was 3.2% compared to 18.7% for the conventional grafts (p < .01), with a subdistribution hazard ratio (SHR) of 0.16 (p = .010). The long-term MACE rate was 27.0% in the no-touch group and 48.3% in the conventional group (p < .01) with a SHR of 0.53 (p = .017). The short-term results were similar in both groups.CONCLUSIONS: Percutaneous coronary intervention in a no-touch vein graft was associated with statistically significantly fewer in-stent restenoses and MACE at long-term follow-up compared to a conventional SVG.}, issn = {0267-6591} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lybeckcharlotte_2025, title = {Long-term risk of HCC in a DAA-treated national hepatitis C cohort, and a proposed risk score}, author = {Lybeck, Charlotte and Bruce, Daniel and Szulkin, Robert and Montgomery, Scott and Aleman, Soo and Duberg, Ann-Sofi}, year = {2025}, journal = {Infectious Diseases}, volume = {57}, number = {3}, pages = {211--233}, doi = {10.1080/23744235.2024.2403703}, url = {1901119}, language = {eng}, publisher = {Taylor & Francis}, keywords = {daa; hcc; viral hepatitis; risk score; surveillance}, abstract = {BACKGROUND: The risk of hepatocellular carcinoma (HCC) remains elevated in cirrhotic hepatitis C patients with sustained virological response (SVR) after DAA treatment. We assessed long-term HCC risk stratified by pretreatment liver stiffness measurement (LSM) and developed a risk score algorithm.METHODS: This register-based nationwide cohort study of 7,227 DAA-treated patients with SVR evaluated annual HCC incidence rates (IRs) and cumulative incidences stratified by pretreatment LSM. The association between LSM and HCC risk was analyzed using multivariate Cox regression. A risk score algorithm was developed and internally validated in 2,664 individuals with LSM >9.5 kPa, assigning each patient a score based on risk factors, proportionally weighted by the association with HCC risk.RESULTS: During a median follow-up of 1.8 years (3.2 years for LSM ≥12.5 kPa), 92 patients (1.3%) developed HCC. The IRs for LSM 9.5-12.4, 12.5-19.9 and ≥20 kPa were 0.21, 0.99 and 2.20 HCC/100 PY, respectively, with no significant risk reduction during follow-up. The HRs (and 95% CI) for LSM 9.5-12.5, 12.5-19.9 and ≥20 kPa are 1.19 (0.43-3.28), 4.66 (2.17-10.01) and 10.53 (5.26-21.08), respectively. Risk score models including FIB-4, alcohol, diabetes, age and LSM effectively stratified patients with LSM >9.5 kPa into low-, intermediate- and high-risk groups, with a Harrell's C of 0.799. Notably, 48% with LSM ≥9.5 kPa and 27% ≥12.5 kPa were classified as low-risk.CONCLUSION: Pretreatment LSM is associated with HCC risk, which remains stable during the initial five years post-SVR. The HCC risk score algorithm effectively identifies low-risk patients, who may not require HCC surveillance.}, issn = {2374-4235} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johnstoneleanne_2025_2, title = {Looking on the bright side! The role of socio-environmental incidents in positively shaping international businesses and industries.}, author = {Johnstone, Leanne}, year = {2025}, journal = {Critical Perspectives on International Business}, volume = {21}, number = {3}, pages = {443--471}, doi = {10.1108/cpoib-08-2023-0079}, url = {1936872}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {institutional theory; legitimacy; multinational enterprises; social activism; socioecological incidents; social isomorphism}, abstract = {The number of socio-ecological incidents involving multinational enterprises (MNEs) is increasing. While there is growing research attention on the role of MNEs in being corporately responsible actors, less is known about how the aftermath of negative socio-ecological incidents can help shape (more) sustainable futures for such businesses and the industries that they exist within. This paper addresses the positive strategic implications for MNEs in the aftermath of well-known social and environmental incidents. Using institutional theory and drawing from three real-life case vignettes, the paper elaborates on the types and role of institutions for (re)gaining legitimacy in MNEs and industries implicated in socio-ecological incidents through the development of a conceptual model that elaborates on common features of institutional change. A new type of institutional pressure, social isomorphism, is revealed, which both strengthens and helps explain the more formalised coercive and normative institutional pressures as a positive force for change in the MNEs and industries implicated in negative socio-ecological incidents such as those described. The paper offers clear strategic advice for managers in MNEs implicated in negative socio-ecological incidents. The paper puts forward a conceptual model that presents some common features of institutional change (types, pathways and relationships) for the international business context in the aftermath of negative socio-ecological incidents. Its theoretical contribution regards putting forward the concept of social isomorphism for neo-institutional theory in international fields.}, issn = {1742-2043} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_skargrenfredric_2025_1, title = {Looking under the Hood of Digital Government : A Digital Index Framework for Assessing Digitalisation of Core Processes in Government Agencies}, author = {Skargren, Fredric}, year = {2025}, url = {1967817}, language = {eng}, publisher = {Örebro University}, keywords = {digital government; public administration; benchmarks; maturity models; design science; core processes; classification}, abstract = {This thesis addresses the question: How can a Digital Index Framework (DIF) provide an assessment of digitalisation of core processes in government agencies? It aims to understand how digitalisation can be assessed in the context of public administration and core processes. The research is grounded in the multi-disciplinary field of digital government and applies mixed methods: literature review, design science and case studies. The thesis finds that benchmarking digital government faces recurring criticism regarding how assessments are conducted and what they measure. By examining the design of a DIF, the thesis proposes design principles for assessing digitalisation, focusing on how digital technologies support administrative processes. This includes a process view highlighting interaction with society, internal case handling and data exchange. Examining digitalisation through a DIF highlights core processes and contributes to scholarly discussions on linking public administration with digitalisation. Focusing on core processes, the thesis presents a classification of eight types, which can support both assessing digitalisation and studying phenomena such as artificial intelligence and digital services. The thesis also contains results concerning the influences from the practical implementation of the DIF among practitioners in government agencies. The engagement with the DIF fostered skill development, deeper reflections on cross-government processes and led to policy learning and change.}, file = {https://oru.diva-portal.org/smash/get/diva2:1967817/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_11, title = {Love Can Still Liberate}, author = {Johansson Wilén, Evelina and Wemrell, Maria}, year = {2025}, journal = {Jacobin}, url = {2006264}, language = {eng}, publisher = {Jacobin Press}, issn = {2470-6930} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_malinovschiandrei_2025, title = {Low alveolar volume is related to respiratory symptoms in individuals without chronic airflow limitation}, author = {Malinovschi, Andrei and Zhou, Xingwu and Blomberg, Anders and Hamrefors, Viktor and Johnsson, Åse and Persson, Hans Lennart and Sköld, Magnus and Sundh, Josefin and Wollmer, Per}, year = {2025}, journal = {European Respiratory Journal}, volume = {66}, number = {Suppl. 69}, doi = {10.1183/13993003.congress-2025.PA965}, url = {2037699}, language = {eng}, publisher = {European Respiratory Society}, abstract = {Alveolar volume (VA) is estimated by inert gas distribution when measurements of diffusing capacity for carbon monoxide are performed. Access to body plethysmography is limited and therefore we wanted to assess if estimations of VA are associated with respiratory symptoms in individuals without chronic airflow limitation.A total of 28,928 individuals from the multicenter, population-based Swedish CArdioPulmonary bioImage Study (SCAPIS) had available measurements of VA. We defined by means of lambda-mu-sigma models reference values and lower limit of normal (LLN) for alveolar volume in the never-smoking, respiratory healthy subgroup. We studied factors associated with low alveolar volume (<LLN) in the subgroup with post-bronchodilator FEV1/FVC≥0.70 (n=26,081).A low VA was more frequently found in overweight and obese persons compared with normal weight persons (5.0%, 11.1% vs 3.6%, both p<0.001). No significant differences were found regarding smoking status, age or sex. A low alveolar volume was more often found in subjects with wheeze vs without wheeze 11.9% vs 5.3%, p<0.001. Findings were similar for cough 7.4% vs 5.3%, p<0.001, sputum production 8.1% vs 5.4%, p<0.001 and breathlessness 15.1% vs 5.2%, p<0.001. All associations with respiratory symptoms were confirmed in a logistic regression model where adjustments were performed for smoking status, BMI, age, sex and study center.In conclusion, in this large population-based study, we found relations between reduced alveolar volume and respiratory symptoms in subjects without chronic airflow limitation. Further studies are needed to understand if these findings are due to peripheral airway obstruction or reduced lung volume.}, issn = {0903-1936} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wihljessica_2025, title = {Lower MeDiC score is associated with non-referral to multidisciplinary team meeting discussion in bladder cancer patients : a nationwide and population-based study}, author = {Wihl, Jessica and Hagberg, Oskar and Aljabery, Firas and Gårdmark, Truls and Hosseini, Abolfazl and Jahnson, Staffan and Jerlström, Tomas and Ströck, Viveka and Söderkvist, Karin and Ullén, Anders and Holmberg, Lars and Häggström, Christel and Liedberg, Fredrik}, year = {2025}, journal = {Acta Oncologica}, volume = {64}, pages = {616--622}, doi = {10.2340/1651-226X.2025.42756}, url = {1956493}, language = {eng}, publisher = {Taylor & Francis}, keywords = {bladder cancer; multidisciplinary team meeting; treatment recommendation; guidelines; scoring system; complexity factors}, abstract = {BACKGROUND AND PURPOSE: The Measure of Case-Discussion Complexity (MeDiC) tool was created to gauge case complexity at multidisciplinary team meetings (MDTM) for case selection and prioritization. We aimed to assess applicability and association with MeDiC score and non-compliance with national guideline-recommendations for MDTM referral in a bladder cancer setting.MATERIAL AND METHODS: A modified MeDiC scoring system was applied in 8955 subjects with localized (T1-T4N0M0) or metastasized disease as per the Bladder Cancer Data Base Sweden (BladderBaSe) 2.0. Association between MeDiC score and not being discussed at MDTM was investigated by multivariable logistic regression, and further explored in relation to calendar time period, healthcare region, age at diagnosis and hospital volume.RESULTS AND INTERPRETATION: Median total MeDiC score was lower in individuals not being discussed at an MDTM (7.0 Inter Quartile Range [IQR] 6.0-9.0) compared to those who were (8.0 IQR 6.0-10.0). Adjusted odds ratio for not being discussed at an MDTM was 2.1 (95% confidence interval [CI] 1.8-2.4) for a MeDiC score in the lower quartile, as compared to the highest quartile, with higher estimates when performing stratified analyses in later calendar years and in specific healthcare regions. Our data indicate that the MeDiC score is applicable in bladder cancer patients, and we identified an association between lower MeDiC score and not being discussed at an MDTM.}, issn = {0284-186X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_joelsonanders_2025, title = {Lumbar spinal stenosis with degenerative spondylolisthesis in twins : An observational study from the national Swedish spine registry and the Swedish twin registry}, author = {Joelson, Anders and Szigethy, Lilla and Sigmundsson, Freyr Gauti}, year = {2025}, journal = {Journal of clinical neuroscience}, volume = {135}, doi = {10.1016/j.jocn.2025.111155}, url = {1941704}, language = {eng}, publisher = {Elsevier}, keywords = {concordance; degenerative spondylolisthesis; heredity; lumbar spinal stenosis; twin study}, abstract = {BACKGROUND: Only a few studies have investigated the genetic background of lumbar spinal stenosis (LSS) with degenerative spondylolisthesis (DS) requiring surgery. The purpose of this study was to determine the concordance rates for LSS with DS requiring surgery by studying monozygotic (MZ) and dizygotic (DZ) twin pairs.METHODS: Patients between 18 and 85 years of age who underwent surgery for LSS with DS between 1996 and 2022 were identified in the national Swedish spine registry (14,614 patients) and matched with the Swedish Twin Registry to identify MZ and DZ twins. The concordance rates, the MZ/DZ concordance ratios, and the limits of genetic determination were calculated.RESULTS: We identified 145 twin pairs (27 MZ and 118 DZ pairs) of whom 1 or both twins underwent surgery for LSS with DS. We found no concordant MZ pair and 2 concordant DZ pairs. When we evaluated pairs where at least one twin was operated for LSS with DS we found 2 concordant MZ pairs and 4 concordant DZ pairs (the co-twins were operated for LSS without DS) resulting in the probandwise concordance rate 0.14 (95% CI, 0 to 0.31) for MZ twins and 0.07 (95% CI, 0.02 to 0.13) for DZ twins. The probandwise MZ/DZ concordance ratio was 2.1 (95% CI 0-11.9). The limits of genetic determination were 0.27 to 0.36.CONCLUSIONS: Our findings suggest that heredity may not be of major etiologic importance in most cases of LSS with DS requiring surgery.}, issn = {0967-5868} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wangjuan_2025_1, title = {Lung Function Decline in COPD - Relations to Changes in Symptom Burden, Inflammation, and Comorbidities}, author = {Wang, Juan and Ställberg, Björn and Hårdstedt, Maria and Bröms, Kristina and Gonzalez Lindh, Margareta and Farkhooy, Amir and Palm, Andreas and Lisspers, Karin and Högman, Marieann and Malinovschi, Andrei}, year = {2025}, journal = {COPD: Journal of Chronic Obstructive Pulmonary Disease}, volume = {22}, number = {1}, doi = {10.1080/15412555.2025.2525433}, url = {1982364}, language = {eng}, publisher = {Informa Healthcare}, keywords = {c-reactive protein; chronic obstructive pulmonary disease; fev1; inflammatory biomarkers; lung function decline; symptom burden assessment}, abstract = {PURPOSE: The study aims to improve the knowledge on the associations between comorbidities, symptom burden, inflammatory biomarkers and lung function deterioration in chronic obstructive pulmonary disease (COPD). MATERIALS ANDMETHODS: Of the 572 COPD subjects initially included in the 2014-2016 Tools for Identifying Exacerbations in COPD study in Sweden, 228 had lung function data at the 7-year follow-up. Symptom burden was assessed by the modified British Medical Research Council scale of dyspnoea (mMRC), the COPD Assessment Test (CAT) and the Clinical COPD Questionnaire (CCQ). Relative lung function decline was assessed as decline in forced expiratory volume in one second (FEV1) from baseline/year.RESULTS: Lower baseline symptom burden (mMRC, CAT and CCQ), higher FEV1 and FEV1% predicted, higher forced vital capacity (FVC) and having atrial fibrillation were associated with larger absolute FEV1 decline. Associations were found for having atrial fibrillation at baseline and larger relative FEV1 decline (Beta = -1.60, p = 0.005). Increased symptom burden (value at follow-up minus value at baseline), assessed by mMRC, CAT and CCQ, was positively associated with both larger absolute FEV1 decline (mMRC: Beta = 6.4, p = 0.009; CAT: Beta = 1.63, p = 0.002; CCQ: Beta = 10.6, p < 0.001) and larger relative FEV1 decline (mMRC: Beta = 0.44, p = 0.003; CAT: Beta = 0.13, p < 0.002; CCQ: Beta = 0.82, p < 0.001). Moreover, an increase in C-reactive protein (CRP) levels at follow-up was related to larger, both absolute and relative, FEV1 decline (Beta = 1.14, p = 0.031 and Beta = 0.07, p = 0.019, respectively).CONCLUSIONS: Changes in systemic inflammation and symptom burden between two visits were positively associated with a 7-year lung function decline.}, issn = {1541-2555} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisioannis_2025_4, title = {Lupus Low Disease Activity State and organ damage in relation to quality of life in systemic lupus erythematosus : a cohort study with up to 11 years of follow-up}, author = {Parodis, Ioannis and Stephens, Thomas and Dominicus, Annica and Eek, Daniel and Sjöwall, Christopher}, year = {2025}, journal = {Rheumatology}, volume = {64}, number = {2}, pages = {639--647}, doi = {10.1093/rheumatology/keae120}, url = {1840735}, language = {eng}, publisher = {Oxford University Press}, keywords = {health-related quality of life; lupus low disease activity state; systemic lupus erythematosus}, abstract = {OBJECTIVES: Beyond prevention of organ damage, treatment goals in systemic lupus erythematosus (SLE) include optimisation of health-related quality of life (HRQoL). The Lupus Low Disease Activity State (LLDAS) has received increasing attention as a goal whenever remission cannot be achieved. How SLE disease activity, organ damage, and LLDAS attainment relate to patient-reported outcomes (PROs) is not fully explored, which formed the scope of this investigation.METHODS: We included 327 patients with SLE from a tertiary referral centre. Longitudinal registrations of disease activity using SLEDAI-2K and physician global assessment (PhGA), organ damage using the SLICC/ACR damage index (SDI), pharmacotherapies, EQ-5D-3L data, as well as visual analogue scale (VAS) scores for fatigue, pain, and overall SLE-related health state over a median follow-up time of 8.5 years were analysed.RESULTS: In the overall population, as well as subgroups of patients with recent-onset SLE and those with clinically active, autoantibody-positive disease, LLDAS attainment, lower PhGA, and lower clinical SLEDAI-2K scores were associated with favourable HRQoL by EQ-5D-3L and VAS assessments, while increasing SDI scores were associated with poor PROs yet not fatigue in the overall population. PROs were further enhanced by being in LLDAS sustainedly. In fully adjusted models of the entire study population, LLDAS attainment and lower disease activity were associated with favourable PROs, irrespective of SDI.CONCLUSION: In one of the longest to date observational studies, we demonstrated that low disease activity and being sustainedly in LLDAS were coupled with favourable HRQoL, pain, fatigue, and overall health experience, irrespective of organ damage.}, issn = {1462-0324} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisioannis_2025_5, title = {Lupus nephritis}, author = {Parodis, Ioannis and Rovin, Brad H. and Tektonidou, Maria G. and Anders, Hans-Joachim and Malvar, Ana and Mok, Chi Chiu and Mohan, Chandra}, year = {2025}, journal = {Nature reviews. Disease primers}, volume = {11}, number = {1}, doi = {10.1038/s41572-025-00653-y}, url = {2001315}, language = {eng}, publisher = {Nature Publishing Group}, abstract = {Lupus nephritis (LN) is a type of glomerulonephritis and one of the most serious complications of systemic lupus erythematosus (SLE). LN affects 25-60% of patients with SLE, with incidence and prevalence varying by age, sex, ethnicity and socioeconomic factors. LN predominantly develops within 5 years of an SLE diagnosis and, for many patients, it is the initial manifestation that leads to the recognition of SLE. In some patients, LN may develop late in the disease course, highlighting the importance of persistent awareness of its symptoms and signs. Despite an increasing understanding of disease biology and more effective treatment options, LN remains a substantial cause of morbidity and mortality as it can lead to irreversible kidney failure and associated complications. Risk factors for progression to kidney failure include persistent proteinuria, low glomerular filtration rate, hypertension at diagnosis and frequent disease flares. LN pathogenesis involves complex immune dysregulation, with key pathways including type I interferon signalling, calcineurin activation, and B and T cell dysfunction. Several immunomodulatory drugs are used for the management of LN, and treatment paradigms are increasingly shifting towards multi-agent regimens. Along with appropriate pharmacotherapy, multidisciplinary care tailored to the patient's individual needs, involving rheumatologists, nephrologists, social workers and other health professionals, is crucial for holistically addressing both the immune and non-immune risk factors for progressive kidney function loss and for maximizing kidney lifespan in LN.}, issn = {2056-676X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisioannis_2025_6, title = {Lupus nephritis trials network (LNTN) repeat kidney biopsy-based definitions of treatment response : A systematic literature review-based proposal}, author = {Parodis, Ioannis and Cetrez, Nursen and Palazzo, Leonardo and Alberton, Valeria and Anders, Hans-Joachim and Bajema, Ingeborg M. and Costedoat-Chalumeau, Nathalie and Malvar, Ana and Rovin, Brad H. and Sanchez-Guerrero, Jorge and Zhao, Ming-Hui and Weinmann-Menke, Julia and Tektonidou, Maria G. and Houssiau, Frédéric A.}, year = {2025}, journal = {Autoimmunity Reviews}, volume = {24}, number = {7}, doi = {10.1016/j.autrev.2025.103810}, url = {1949956}, language = {eng}, publisher = {Elsevier}, keywords = {autoimmunity; kidney biopsy; lupus nephritis; systemic lupus erythematosus}, abstract = {Within the frame of the Lupus Nephritis Trials Network (LNTN), we conducted a systematic literature review (SLR) to propose kidney tissue-based definitions of treatment outcomes in lupus nephritis (LN). Given the limitations of clinical markers like proteinuria in predicting immunological, histological, and long-term outcomes, our work emphasises the importance of repeat kidney biopsies. Such biopsies help identify discordance between clinical and histological response, which has implications for long-term kidney outcomes. The research objectives of this SLR focused on defining repeat biopsy-based treatment response and histological remission, and their associations with long-term outcomes. The SLR reviewed studies published from 2000 to 2022, identifying 20 eligible works. Histological response was commonly defined by changes in the National Institutes of Health (NIH) Activity Index (AI), with response indicated by a decrease of ≥50 % and to ≤3. Remission was most commonly defined as an AI score of 0. These benchmarks were associated with improved long-term renal outcomes, such as reduced flare rates and preserved kidney function. Conversely, NIH AI scores ≥4 and NIH Chronicity Index (CI) scores ≥4 were associated with poor prognosis, highlighting their predictive utility. Consensus definitions were established through expert panel deliberation, setting a foundation for standardising LN treatment evaluation in clinical trials and observational studies. These definitions are not intended for routine clinical decisions but aim to enhance uniformity and comparability in research, especially when repeat kidney biopsies are performed, an approach strongly advocated by our work. Further validation through ongoing initiatives and molecular characterisation efforts will refine these criteria, fostering advances in LN management and patient outcomes.}, issn = {1568-9972} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_warnolfsa_2025, title = {Lymph node surgery after centralization of penile cancer care in Sweden - extent of use and complications}, author = {Warnolf, Åsa and Baseckas, Gediminas and Glombik, Dominik and Hagberg, Oskar and Kirrander, Peter and Kohestani, Kimia and Liedberg, Fredrik and Nordlund, Per and Persson, Erik and Gerdtsson, Axel}, year = {2025}, journal = {Scandinavian journal of urology}, volume = {60}, number = {Suppl. 223}, pages = {20--20}, url = {1998974}, language = {eng}, publisher = {Medical Journals Sweden AB/MJS Publishing}, abstract = {Introduction: Curative penile cancer (PeCa) surgery was in 2015 centralized to two hospitals in Sweden. This study compares the use of lymph node surgery and complication rates before and after the centralization.Method: All 1079 patients with invasive PeCa in the Swedish National Penile Cancer Register (NPECR) diagnosed between 2009 and 2020 were included, 458 before and 621 after centralization. Proportion of patients subjected to lymph node surgery 2009-2014 vs 2015-2020 was compared with Pearson’s Chi-squared test. Odds ratios (OR) for complications were calculated using a logistic regression model adjusting for age, nodal stage, and extent of penile surgery. Continuous variables were presented as medians with inter quartile ranges (IQR) and compared with Wilcoxon’s rank sum test.Results: Before centralization 270/458 (59%) of patients were subjected to lymph node surgery compared to 474/621 (76%) after 2014. Overall complication rate for patients undergoing such surgery was similar (35%) before and after centralization. After Dynamic Sentinel Node Biopsy (DSNB) overall complications increased from 17% (22/126) to 32% (91/288) after centralization corresponding to an adjusted OR of 1.89 (95% confidence interval (CI) 1.09-3.27). For lymphocele, lymphedema or infection after modified or radical inguinal lymphadenectomy or pelvic lymphadenectomy, the adjusted OR was 0.47 (95% CI 0.29-0.75) after centralization. The register-based setting is a study limitation.Conclusion: The proportion men receiving lymph node surgery increased and risk of lymphedema, lymphocele and infection after inguinal and pelvic lymph node surgery decreased after centralization of PeCa care. }, issn = {2168-1805} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonjosephssonmaria_2025, title = {Lysistrate- Återkomsten: -en musikalisk gestaltning av fred, frihet, feminism och framtid : Lecture-Recital}, author = {Johansson Josephsson, Maria}, year = {2025}, pages = {34--35}, url = {2029840}, language = {swe}, keywords = {lysistrrate - återkomsten; maria jojo & robin af; maria johansson josephsson; maria olsson; lysistrate; feminism}, abstract = {Lysistrate- Återkomsten:-en musikalisk gestaltning av fred, frihet, feminism och framtid.  Att skriva musik och texter till, samt gestalta politiskt orienterade föreställningstexter.  I en samtid där en mängd olika konspirationsteorier figurerar, där vi inte kan veta säkert vad som är sant eller falskt, där sanna fakta, falska fakta, mina fakta eller sanningen enligt mig, blir en del av samhällsbyggets vardagliga retorik tror jag att den konstnärliga gestaltningen har en oerhört viktig plats. I denna vår nu-levda kontext står musiken och den möjliga gestaltningen av densamma som en oerhört viktig kraft för att spegla och möjliggöra en annan typ av uppfattning och omfattning av det vi är med om. I mitt arbete som kompositör, sångerska och skådespelare har jag bl.a fått uppdragen att för Kungliga Dramaten i Stockholm skriva och framföra text och musik till Erik Uddenbergs text Konspiration som regisserades av Suzanne Osten, samt till föreställningen Lysistrate -Återkomsten, en fri tolkning av Aristofanes text skriven av Maria Olsson med regi av Sara Jangfeldt och Fredrik Meyer på Soppteatern vid Kulturhuset i Stockholm.   Båda dessa kompositions-uppdrag ser jag som starkt politiskt inriktade. Lysistrate – återkomsten är främst   en kritik av de våldsamma konflikter som pågår i vårt närområde men också en berättelse om frihet, feminism och en möjlig framtid. I konspiration möter vi ett berättande där vi kanske plötsligen får syn på att inget eller allting är som vi trott. Sanningarna var kanske lögner, eller så var de sanningar i alla fall. Föreställningen tar upp olika konspirationsteorier och relaterar dem i viss mån till synen på vårt folkhemsbygge från ett mer kollektivt 1960-tal till ett mer individualistiskt samhällsbygge med individen i fokus. Jag vill i denna lecture-recital dela med mig av det material och de konstnärliga val jag gjorde utifrån analysen av de narrativ jag ombads ton och text-sätta samt gestalta. Presentationsform:  Lecture-recital Flygel/ piano och mikfrofon- PA (samt projektor och ljudanläggning) Författare: Maria Johansson JosephssonInstitutionstillhörighet: Universitetslektor, Musikalisk gestaltning Musikhögskolan, Örebro universitet maria.johansson-josephsson@oru.se } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mossbergkarin_2025, title = {Läkarstudenters beredskap för vetenskapligt baserat arbete : Enkätstudie hos sistaterminsstudenter på läkarprogrammet [Preparing for patient work founded on evidence in medical school - a questionnaire study on final-year medical students]}, author = {Mossberg, Karin and Garwicz, Martin and Henriksson, Pontus and Möller, Riitta and Naumburg, Estelle and Wahlberg, Jeanette and M Wallerstedt, Susanna}, year = {2025}, journal = {Läkartidningen}, volume = {122}, url = {1927770}, language = {eng}, publisher = {Läkartidningen Förlag AB}, abstract = {Totalt 433 termin 11-studenter vid 6 lärosäten svarade på hur läkarprogrammet förberett dem för evidensbaserat patientarbete.Drygt 7 av 10 uppgav att de fått träna på att granska vetenskapliga artiklar enligt mall, men färre att de tränat på andra moment i en systematisk översikt.Medianstudenten hade 3 av 5 rätt på kunskapsfrågor relaterade till HTA, men en fall–kontrollstudie, ett skogsdiagram och begreppet kostnadseffektivitet tolkades ofta på fel sätt.Undervisning i HTA samt poänggivande moment i tillämpad evidensbaserad medicin under kliniska terminer var förknippade med upplevelsen att läkarprogrammet gett tillräcklig färdighet i hur man baserar patientarbete på vetenskap.;Several of the requirements for obtaining a medical degree according to the Swedish Higher Education Ordinance illustrate the scientific basis of the profession, and systematic reviews as well as health technology assessments (HTA) constitute cornerstones in evidence-based medicine. In this study, medical students' experience of scientific education related to the profession was explored, and their knowledge achieved was sampled by five multiple-choice questions (MCQ). A total of 433 out of 641 students attending the final semester in six medical schools in Sweden participated (response rate: 68%). Most of them experienced that a majority of the scientifically related learning outcomes for the medical degree had been adequately examined. Regarding the steps of a systematic review, 60% stated that they had been trained to define a specific research question, 64% to find relevant literature according to such a specific research question, 72% to assess scientific articles according to a checklist, 40% to compile results from several studies, and 35% to assess the certainty of evidence according to GRADE. Only 6% stated that they had received education regarding HTA, a factor that was strongly associated with students' perception that they had obtained adequate skills regarding how patient work is based on scientific evidence (adjusted odds ratio [OR] 14.1; 95% CI 1.80-110). Such an association was also found for credit-awarded hands-on evidence-related learning activities during clinical courses (OR 2.72; 95% CI 1.02-7.24). The median student answered 3 of 5 MCQs correctly. The results of a case/control study, a forest plot, and the concept of cost-effectiveness were frequently interpreted erroneously. In conclusion, several aspects of the scientific basis for professional life as a medical doctor seem to be well covered in the medical degree program, whereas others deserve increased attention.}, issn = {0023-7205} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_urberglinnea_2025, title = {Lärares didaktiska strategier vid motstånd mot miljö- och hållbarhetsundervisning}, author = {Urberg, Linnea and Tryggvason, Ásgeir and Öhman, Johan}, year = {2025}, url = {2013960}, language = {swe}, keywords = {motstånd; ese; miljö- och hållbarhetsutbildning; didaktiska strategier}, abstract = {Det finns en allmän föreställning om ett starkt engagemang för en hållbar omställning bland unga. Tidigare studier om ungas engagemang i hållbar utveckling har främst fokuserat på "goda exempel", där ungdomars aktivism och organisering kring hållbarhets-och miljöfrågor lyfts fram med Fridays for Future som ett framträdande exempel (Molder m.fl., 2021; Sloam m.fl., 2022). Detta är emellertid inte alltid fallet. Bland unga finns även ett utbrett motstånd mot hållbarhetsfrågor (Urberg & Öhman, 2024), men framför allt en brist på intresse och engagemang (Ojala, 2015; Urberg, 2025). Detta motstånd och passivitet har skapat nya utmaningar inom miljö- och hållbarhetsutbildning som kräver en utvecklad didaktisk respons. I denna studie undersöks hur lärare i sin undervisning hanterar motstånd mot hållbar omställning. Studien tar sin metodologiska utgångspunkt i den nordiska/tyska didaktiktraditionen för att förstå lärares handlingar (Hopmann, 2007; Klafki, 2000; Öhman, 2014). Det didaktiska perspektivet används som ett verktyg för att skapa kunskap om lärares undervisningsstrategier. Detta innebär att vårt intresse för lärares handlingar inte endast är ett intresse för handlingar i allmänhet, utan fokuserar på lärares handlingar i förhållande till eleverna och det specifika undervisningsinnehållet, i detta fall hållbar utveckling. I studien har vi därför intervjuat 9 olika yrkesverksamma lärare på grundskolans senare år och på gymnasiet. I analysförfarandet användes kvalitativ innehållsanalys.I studien identifierades tre strategier som lärare använder sig av när elever uttrycker motstånd. I den första strategin, den relationsorienterade, använder lärarna ett tillitsbaserat, icke-dömande och didaktiskt känsligt förhållningssätt och behandlar motstånd som något önskvärt och konstruktivt. Vidare framhöll lärarna att pluralistiska diskussioner inom den värdeorienterade strategin kan bidra till att utmana elevernas värde-positioner. Slutligen identifierades också en kunskapsorienterad strategi där lärarna framhöll en kollektiv syn på kunskap och vetenskap.Den relationsorienterade strategin utgör grunden för dessa lärares hantering av motstånd och konflikter. När den relationella strategin är framgångsrik kan lärarna lägga till den värdeorienterade strategin och den kunskapsorienterade strategin. Gemensamt för alla strategier är dock att lärare vill handla icke-dömande och att de aldrig har som syfte att dominera eleven och genom tvång upprätta ett undervisningsparadigm som möjliggör lärande. Lärarna beskriver att många miljö- och hållbarhetsfrågor är potentiellt kontroversiella och att det ibland kan vara svårt att lyfta och hantera dessa frågor i klassrummet. De framhåller ett pluralistiskt förhållningssätt som lämpligt vid sådana diskussioner även om det också skapar vissa utmaningar. De påpekar att värdefrågor är extra känsliga, eftersom de ofta är kopplade till elevernas materiella och värdemässiga positioner. Hållbarhetsfrågor är också ofta knutna till kön, social bakgrund och etnicitet. Vidare använder lärarna pluralism och ett relationellt förhållningssätt för att avgöra när pluralismens gränser överskrids. Dessa överväganden måste grundas i relationellt förtroende genom ett tillitsbaserat, icke-dömande och didaktiskt känsligt förhållningssätt. } } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_erikssonlinda_2025_1, title = {Läsa akademiska engelska texter}, author = {Eriksson, Linda}, year = {2025}, url = {2014633}, language = {swe}, publisher = {Gleerups Utbildning AB} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_malmstrmhans_2025_1, title = {Läskrisen inom högre utbildning ifrågasätts – de flesta studenter läser och förstår kurslitteraturen}, author = {Malmström, Hans and Eriksson, Linda and Stöhr, Christian}, year = {2025}, url = {1956883}, language = {swe}, keywords = {studenter; läsning; läsvilja; litteractitet; läsförståelse}, abstract = {En central aspekt av akademisk litteracitet är förmågan att läsa och förstå akademiska texter. På senare tid har studenters läsvanor och läsförståelse ifrågasatts av olika aktörer inom högre utbildning – ropen om en ”läskris” har ekat i olika medier. Sektorn är delad i sina åsikter om det verkligen handlar om en kris, och kritiken har stundtals varit hård mot användningen av isolerade observationer och anekdotiska bevis som inlägg i debatten. Mer forskning om studenters akademiska läsning har efterfrågats. Chalmers tekniska högskola (i samverkan med Örebro universitet och avdelningen språkrådet, Institutet för språk och folkminnen) genomförde i januari en enkät med 1 000 slumpmässigt utvalda studenter från ett riksrepresentativt urval. Syftet var att kartlägga studenternas akademiska läsvanor, deras preferenser för svenska respektive engelska texter samt hur väl grundskola och gymnasium förbereder studenter för akademisk läsning. Resultaten visar att en majoritet av studenterna verkar hantera akademisk läsning väl. Det betyder dock inte att det saknas anledning till oro. Uppfattningen om problemets omfattning beror till stor del på vilka förväntningar man har. Studien visar också att läsbeteendet varierar mellan olika grupper av studenter. Statistiskt signifikanta skillnader framträder bland annat mellan manliga och kvinnliga studenter, yngre och äldre studenter, studenter på olika utbildningsnivåer samt inom olika ämnesområden. I den här korta presentationen lyfter vi fram några av studiens nyckelresultat och bjuder in till diskussion om orsaker och konsekvenser kopplat till litteracitet och lärande inom högre utbildning.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_malmstrmhans_2025_2, title = {Läsning i högre utbildning : En kvantitativ studie om studenters läsvanor på svenska och engelska}, author = {Malmström, Hans and Eriksson, Linda and Stöhr, Christian}, year = {2025}, doi = {10.17196/cls.csclhe/2025/02}, url = {1951606}, language = {swe}, publisher = {Chalmers tekniska högskola} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_anderssonida_2025, title = {Lätt att säga, svårt att göra? Om regional strategisk planering i Sverige}, author = {Andersson, Ida and Tunström, Moa}, year = {2025}, journal = {PLAN - tidskrift för planering av landsbygd och tätorter}, number = {3}, pages = {53--59}, url = {2009851}, language = {swe}, publisher = {Föreningen för samhällsplanering}, abstract = {Begreppet ”strategisk planering” har många samhällsplanerare stött på, både under sin utbildning och i yrkeslivet. Men vad betyder det och vilka problem ska den strategiska planeringen lösa? Detta har vi reflekterat över på uppdrag av Tillväxtverket, med anledning av ett regeringsuppdrag om att utveckla stöd för strategisk planering i det regionala tillväxtarbetet (LI2024/01013). Regeringen vill att ett antal myndigheter, däribland Tillväxtverket, ska utveckla kunskaps- och metodstöd för att underlätta regionernas arbete med regional utveckling och de åtaganden som ryms inom lagen om regionalt utvecklingsansvar (SFS 2010:630). Vårt uppdrag från Tillväxtverket har varit att, med utgångspunkt i ett textmaterial bestående av styrdokument, statliga utredningar och facklitteratur, undersöka strategisk planering i det svenska policylandskapet från 2012 och framåt (se Tunström & Andersson, 2025).}, issn = {0032-0560} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_buwaiderali_2025, title = {Machine Learning Models for Predicting Dysphonia Following Anterior Cervical Discectomy and Fusion : A Swedish Registry Study}, author = {Buwaider, Ali and El-Hajj, Victor Gabriel and MacDowall, Anna and Gerdhem, Paul and Staartjes, Victor E. and Edström, Erik and Elmi-Terander, Adrian}, year = {2025}, journal = {The spine journal}, volume = {25}, number = {3}, pages = {419--428}, doi = {10.1016/j.spinee.2024.10.010}, url = {1911284}, language = {eng}, publisher = {Elsevier}, keywords = {cervical spine; dysphonia; machine learning; neurosurgery; outcome; prediction; random forest}, abstract = {BACKGROUND: Dysphonia is one of the more common complications following anterior cervical discectomy and fusion (ACDF). ACDF is the gold standard for treating degenerative cervical spine disorders, and identifying high-risk patients is therefore crucial. PURPOSE: This study aimed to evaluate different machine learning models to predict persistent dysphonia after ACDF.STUDY DESIGN: A retrospective review of the nationwide Swedish spine registry (Swespine) PATIENT SAMPLE: All adults in the Swespine registry who underwent elective ACDF between 2006 and 2020.OUTCOME MEASURES: The primary outcome was self-reported dysphonia lasting at least one month after surgery. Predictive performance was assessed using discrimination and calibration metrics.METHODS: Patients with missing dysphonia data at the one-year follow-up were excluded. Data preprocessing involved one-hot encoding categorical variables, scaling continuous variables, and imputing missing values. Four machine learning models (logistic regression, random forest (RF), gradient boosting, K-nearest neighbor) were employed. The models were trained and tested using an 80:20 data split and 5-fold cross-validation, with performance metrics guiding the selection of the best model for predicting persistent dysphonia.RESULTS: In total, 2,708 were included in the study. Twelve key predictors were identified. Four machine learning models were tested, with the RF model achieving the best performance (AUC = 0.794). The most significant predictors across models included preoperative NDI, EQ5Dindex, preoperative neurology, number of operated levels, and use of a fusion cage. The RF model, chosen for its superior performance, showed high sensitivity and consistent accuracy, but a low specificity and positive predictive value.CONCLUSIONS: In this study, machine learning models were employed to identify predictors of persistent dysphonia following ACDF. Among the models tested, the RF classifier demonstrated superior performance, with an AUC value of 0.790. The RF model identified NDI, EQ5Dindex, and number of fused vertebrae as key variables. These findings underscore the potential of machine learning models in identifying patients at increased risk for dysphonia persisting for more than one month after surgery.}, issn = {1529-9430} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_alwandiahmed_2025_1, title = {Maintenance treatment and diagnostic course in psychotic depression}, author = {Al-Wandi, Ahmed}, year = {2025}, url = {1998876}, language = {eng}, publisher = {Örebro University}, keywords = {psychotic depression; maintenance treatment; diagnostic conversion; diagnostic stability}, abstract = {Aims: The aims of this thesis were to summarize and extend current knowledge on maintenance treatment in psychotic depression and to examine diagnostic conversion rates from psychotic unipolar depression to bipolar disorder and psychotic disorders.Methods: Study I was a systematic review, and Studies II–IV were nationwide observational studies based on Swedish national registers.Results: The systematic review included five controlled studies. Only the comparison between antidepressant–antipsychotic combination therapy and antidepressant monotherapy had been assessed in more than one study, and a meta-analysis of this comparison did not show a significant difference. In Swedish register data, antidepressant monotherapy was associated with a lower risk of rehospitalization or suicide compared with antidepressant–antipsychotic combination therapy. Maintenance treatment with electroconvulsive therapy (ECT) was not associated with a decreased risk of rehospitalization or suicide in patients overall; however, a significant association in favor of maintenance ECT was found among patients aged over 65 years. In patients with psychotic unipolar depression, 17-year conversion rates were 17.5% to psychotic disorders and 14.7% to bipolar disorder.Conclusions: Evidence for adjunctive antipsychotics in the maintenance phase is limited, and they should be used with caution. Maintenance ECT may lower relapse risk in patients over 65 years. Diagnostic conversion to psychotic and bipolar disorders is common, which may have important implications for treatment and prognosis.The epidemiology and treatment of psychotic depression remain understudied, warranting further research.}, file = {https://oru.diva-portal.org/smash/get/diva2:1998876/FULLTEXT03.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_vandenhoogennynke_2025, title = {Making information actionable : how to confidently navigate knowledge mobilization from basic science to implementation}, author = {van den Hoogen, Nynke and MacKenzie, Nicole and Eriksson, Mats}, year = {2025}, url = {1973898}, language = {eng}, keywords = {pain; children; knowledge mobilization}, abstract = {Knowledge mobilization (KM), or the practice of sharing and applying evidence, is vital to make all information collected through research actionable by all interested audiences; but, how do you design a KM strategy that is inclusive and reflective of all disciplines of science? This interactive panel dialogue will explore effective strategies for mobilizing knowledge, from basic science to practical implementation within pediatric pain. Participants will engage with experts who have successfully navigated the complexities of translating research findings into practice in a variety of pediatric pain contexts across the research continuum. Panelists will address key challenges and opportunities to engage in KM practice, including methodologies, interdisciplinary collaboration, engagement of interest holders, and communication barriers. Through short presentations and group discussions, attendees will learn about innovative approaches, tools, and frameworks that facilitate the exchange of knowledge between researchers, practitioners, policy makers, and patients. Participants will leave equipped with practical insights and action plans to enhance their own KM efforts. Join us to contribute to a dialogue that empowers evidence-based decision-making and treatment strategies, and accelerates the path from discovery to real-world application.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bergmonika_2025, title = {Making institutions more reflexive – governance structures for transformative change}, author = {Berg, Monika}, year = {2025}, journal = {Journal of Environmental Policy and Planning}, pages = {1--18}, doi = {10.1080/1523908x.2025.2558697}, url = {1999721}, language = {eng}, publisher = {Routledge}, keywords = {reflexivity; reflexive institutions; environmental governance; transformative change; network governance; bureaucracy}, abstract = {Reflexive institutions are upheld as critical for greening states and societies. However, attempts to increase institutional reflexivity are generally introduced through projects and institutional add-ons, which makes them difficult to maintain, while the established institutions can reproduce unsustainability. This paper explores possibilities for established institutions to become (more) reflexive, assessing two established forms of governance, bureaucracy and networks. It is conceptually argued that institutional structures can enable as well as constrain institutions’ reflexive capacity. The two organizational forms face different combinations of constraints on reflexivity (formal institutions, entrenched interests, and dominant ideas). Two empirical cases are used to illustrate this point: the bureaucratic mining permit process and the network-based organization Fossil-free Sweden. Insights from the two cases suggest, counter to dominant views and organizational trends, that bureaucracy can have a critical function for reflexive institutions. It is argued that bureaucratic structures are essential to balance the constraints on reflexivity and thereby safeguard the inclusion of conflicting perspectives, which are the most valuable seeds for reflexivity. While network-based governance faces less institutional constraints, interest-based and ideational constraints are more entrenched. Exploiting the strengths of each governance form seems critical to effectively and sustainably tackle the environmental challenges that modern society is facing.}, issn = {1523-908X}, file = {https://oru.diva-portal.org/smash/get/diva2:1999721/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_goncalvesricardo_2025_2, title = {Male students’ experiences of preschool teacher-training programs in Sweden and Brazil}, author = {Goncalves, Ricardo and Frödén, Sara}, year = {2025}, url = {1993713}, language = {eng}, keywords = {male preschool teacher-student; higher education; gender; sweden; brazil}, abstract = {Only 4% of ECE staff in Sweden and Brazil are men, despite significant differences in gender equality policies and views on male caregiving. To address this gender imbalance, this study aims to explore the experiences of male preschool teacher students in Sweden and Brazil. What challenges do these students encounter, and which factors contribute to successfully completing preschool teacher education?While previous research often focuses on practicing professionals (Hedlin et al, 2019; Warin, 2015) and masculinity theories (Heikkilä & Hellman, 2017; Haddad & Marques, 2022), fewer studies center on male ECE students, the diversity within this minority group and their sense of belonging in higher education (Grimshaw et al., 2023). To address this gap, this study combines various minority theories (Frost & Meyer, 2023; Diamond & Alley, 2022; Moss Kanter, 1977). Thematic data analysis is performed using an abductive approach within a qualitative interpretative paradigm. In-depth, semi-structured interviews were conducted with fourteen male students at the end of the preschool teacher training program in Sweden and Brazil. The students gave informed consent, and pseudonyms were used to protect their identities. To ensure voluntary participation, the interviewing researchers had no examining role toward the students and emphasized their right to withdraw consent at any time without affecting their education.The results highlight the importance of male representation, mentorship, social network support, positive work experience in preschools, and the impact of intersecting categories like ethnicity and age. Also, several strategies for developing an inclusive and supportive environment for male preschool teacher students are suggested.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ciminomatteomaria_2025, title = {Management and outcome variability in hernia-related small bowel obstruction : insights from the SnapSBO study}, author = {Cimino, Matteo Maria and Bass, Gary Alan and Kurihara, Hayato and Bellio, Gabriele and Porta, Matteo and Cayre, Luigi and Mohseni, Shahin and Lee, Matthew J. and Kaplan, Lewis J. and Martinez-Casas, Isidro}, year = {2025}, journal = {BJS Open}, volume = {9}, number = {6}, doi = {10.1093/bjsopen/zraf127}, url = {2016832}, language = {eng}, publisher = {Oxford University Press}, keywords = {evidence-based practice; patient outcome assessment; prospective studies}, abstract = {BACKGROUND: Small bowel obstruction (SBO) due to hernia remains a prevalent surgical emergency disproportionately affecting elderly and co-morbid populations. Limited high-quality data exist to guide evidence-informed interventions for hernia-related SBO. This study explored the management and outcomes of hernia-related SBO (hSBO) for patients captured in European Society for Trauma and Emergency Surgery (ESTES) SnapSBO database.METHODS: SnapSBO is a prospective multicentre time-bound study that accrued consecutive inpatient admissions between November 2023 and May 2024. The present analysis was restricted to patients with abdominal wall hernias. Management pathways were categorized as direct to surgery (DTS), successful non-operative management (NOM), or surgery after trial of NOM (NOM-T). Outcomes of interest included complications, 30-day in-hospital mortality, length of hospital stay (LOS), and functional recovery assessed through patient-reported outcome measures (PROMs) using the PRO-diGI tool. RESULTS: Among 1737 patients, SBO due to abdominal wall hernia was noted in 386. The median patient age was 73 (range 16-98) years, with 64.8% of patients aged > 65 years. Primary inguinal/abdominal wall hernias were the most common (62.2%). Of the patients, 51.6% were categorized as DTS, where 17.1% required surgery after NOM-T. NOM was successful in 31.2% of patients. Parastomal hernia management led to the highest complication rate (57.1%) and prolonged postoperative LOS (mean(standard deviation) 9.1(4.8) days; P = 0.030) compared with other hernia types. Functional recovery measured in 218 patients was significantly worse in those with parastomal hernia than in those with incisional or primary inguinal hernias (mean(standard deviation) bowel function scores 68.6(22.5) versus 83.6(17.6) and 82.0(20.3), respectively; P = 0.009).CONCLUSION: There is significant variability in practice and outcomes for hSBO management. Patients with parastomal hernias represent a high-risk subgroup. Future research should focus on PROMs and in developing evidence-based, context-specific guidelines for hSBO management.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wahllfmartina_2025, title = {Management of community-acquired pneumonia in immunocompetent adults : updated Swedish guidelines}, author = {Wahllöf, Martina and Hedlund, Jonas and Lundqvist, Anders and Nilsson, Anna C. and Inghammar, Malin and Spindler, Carl and Nauclér, Pontus and Athlin, Simon}, year = {2025}, journal = {Infectious Diseases}, volume = {57}, number = {10}, pages = {979--1015}, doi = {10.1080/23744235.2025.2543077}, url = {1991590}, language = {eng}, publisher = {Taylor & Francis}, issn = {2374-4235} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_tinjanmalin_2025, title = {Managers as Creators of Inertia : A Study on Digital Transformation Narratives and Inertia in the Swedish Public Sector}, author = {Tinjan, Malin}, year = {2025}, pages = {1906--1915}, doi = {10.24251/HICSS.2025.236}, url = {1929347}, language = {eng}, keywords = {case study; public sector; digital transformation; inertia; narratives}, abstract = {Overcoming inertia is a top priority for managers in digital transformation; however, this study investigates how public sector managers create inertia in digital transformation through alibi narratives. Through a case study of managers in the Swedish public sector, the study analyzes how managers legitimize and reinforce stagnation rather than promoting change. Four meta-alibi narratives are identified, that facilitate managers´ understanding of the digital transformation process while simultaneously resulting in unintentional inertia. By exploring these alibi narratives, the study challenges the traditional view of managers solely as agents of change, revealing their complex role as both facilitators and impediments to digital transformation. This research provides valuable insights into the micro-level dynamics of digital transformation while highlighting the need for nuanced strategies that address the resistance within public sector organizations.}, file = {https://oru.diva-portal.org/smash/get/diva2:1929347/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_granberganette_2025_1, title = {Managers' perceptions of organizational readiness for change within disability healthcare : a Swedish national study with an embedded mixed-methods approach}, author = {Granberg, Anette and Lundqvist, Lars-Olov and Duberg, Anna and Matérne, Marie}, year = {2025}, journal = {BMC Health Services Research}, volume = {25}, number = {1}, doi = {10.1186/s12913-025-12808-4}, url = {1956677}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {disability; implementation; managers; mixed-methods approach; organizational readiness}, abstract = {BACKGROUND: People with disabilities experience significant health inequities compared with the general population. Addressing these inequities requires the development and implementation of tailored interventions, but a gap often exists between recommended best practices and the actual care provided. Successful implementation is complex, involving multiple organizational factors. Assessing organizational readiness for change is crucial to overcome barriers and improve health outcomes for people with disabilities. This study aims to examine managers' perceptions of their organization's readiness for change regarding the implementation of interventions within disability healthcare in Sweden.METHODS: This descriptive cross-sectional study employs an embedded mixed-methods approach. The primary approach for the overall study is based on quantitative data, while qualitative data is analyzed to provide supplementary deepened information. Both types of data were collected simultaneously through a web-based survey. The data analysis involves various statistical techniques for the quantitative data and inductive content analysis for the qualitative data.RESULTS: Several key factors influence managers' perceptions of their organization's readiness for change, including gender, age, tenure, organizational type, managerial level, and experience. Enabling factors for implementation include trust-based leadership, staff involvement, motivation, and engagement. Barriers include complex processes, lack of support, resistance and fear, and insufficient time and resources.CONCLUSIONS: This study highlights the complexity of organizational readiness for disability healthcare interventions, shaped by both individual and organizational factors. In particular, managerial characteristics, organizational dynamics, and resource availability play key roles. These findings suggest that a comprehensive strategy can strengthen healthcare organizations' ability to navigate implementation challenges effectively.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ljungqvistolle_2025, title = {Managing surgical stress : principles of enhanced recovery and effect on outcomes}, author = {Ljungqvist, Olle}, year = {2025}, journal = {Clinical Nutrition ESPEN}, volume = {67}, pages = {56--61}, doi = {10.1016/j.clnesp.2025.02.023}, url = {1943888}, language = {eng}, publisher = {Churchill Livingstone} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_westerdahlelisabeth_2025, title = {Many barriers to overcome before the 'no antibiotic' approach to mild community-acquired pneumonia in young children can become a routine practice}, author = {Westerdahl, Elisabeth and Giezeman, Maaike}, year = {2025}, journal = {Evidence-Based Nursing}, volume = {29}, number = {1}, doi = {10.1136/ebnurs-2024-104015}, url = {1860371}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, issn = {1367-6539} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dereviankinmike_2025, title = {Mapping global exposure to POPs in human milk through multivariate fingerprinting}, author = {Dereviankin, Mike and Sandau, Court and Fiedler, Heidelore}, year = {2025}, journal = {Journal of Hazardous Materials}, volume = {498}, doi = {10.1016/j.jhazmat.2025.139923}, url = {2000392}, language = {eng}, publisher = {Elsevier}, keywords = {biomonitoring; dimensionality reduction; environmental forensics; human milk; persistent organic pollutants (pops)}, abstract = {Many persistent organic pollutants (POPs) in human milk present environmental and health concerns, particularly for vulnerable populations such as breastfed infants. This study applied a data exploration dimensionality reduction workflow using Uniform Manifold Approximation and Projection (UMAP) for POP measurements in human milk. This approach focuses on identifying and comparing the compositional patterns-or 'fingerprints'-of POPs rather than just measuring their concentrations. The UMAP approach revealed detailed variations in POP fingerprints that were not detectable with traditional univariate approaches. UMAP approach also improves upon other multivariate approaches, such as hierarchical cluster analysis (HCA) and principal component analysis (PCA). Unlike previous studies focusing solely on concentration differences, UMAP identified distinct regional and economic POP fingerprints. Lower-income countries showed POP fingerprints dominated by DDT-related compounds, while higher-income regions showed distinct fingerprints with greater contributions from PCBs and other legacy pollutants. Temporal analysis captured shifts in POP fingerprints after 2001, corresponding with the expansion from initial focus on PCDD, PCDF, and PCB to the broader group of the original 12 POPs listed under the Stockholm Convention. These results demonstrate how dimensionality reduction techniques, particularly UMAP, can distinguish compositional POP fingerprints across geospatial, temporal, and economic factors, providing a comparative framework for understanding global exposure patterns.}, issn = {0304-3894} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_primusroberts_2025_1, title = {Mapping the landscape and effects of performance analysis technologies in Swedish elite soccer}, author = {Primus, Robert S. and Karlsson, Martin}, year = {2025}, url = {1966327}, language = {eng}, keywords = {performance analysis; technology; swedish elite football}, abstract = {During the last few decades, technologies to monitor, test, and analyze athletes’ performance have been developed, such as global positioning systems (GPS), stadium camcorders, and heart rate monitors (Cullinane et al., 2024; Svensson & Svensson, 2021). Data from these sources is central to sports clubs’ management of athletes’ performances, and Robertson (2020) argues that the development of data gathering in sport has led to a new scenario for coaching staff, athletes, and performance analysts, where adaptive tools are essentially required to understand the needs of sports performance. At the forefront are economically strong clubs in the major leagues (Krizkova et al., 2021), but considerable growth is occurring as technologies become more affordable (Brink & Lemmink, 2018).However, there is a growing body of literature that points to negative consequences. ‘Tech-data’ tends to govern too much, resulting in a distortion of lived experience and the dehumanization of both athletes and coaches (Gamble et al., 2020; Woods et al., 2021). Ultimately, what is at stake is who and what should make the decisions regarding athletes’ performance. Studies in this area have mainly been conducted in the Anglosphere on men’s sports, which limits the relevance of the conclusions drawn (Mulvenna, 2024; Nicholls et al., 2018). To provide more informed recommendations to sports organizations, research is needed on contexts with different conditions and resources, as well as on women’s sports (Barker-Ruchti et al., 2021; Martin et al., 2018).This study responds to this call. Using Swedish men’s and women’s elite football as an example—a context that has recently begun to invest in emerging technologies (Barker-Ruchti et al., 2021)—the purpose of this study is to advance the understanding of the effects of using technology in the management of athletes’ performance. The specific aims are: 1) to map the landscape of performance analysis technologies in Swedish elite football in terms of a) what is used, b) why it is used, and c) how it is used; and 2) to illuminate how the use of technology affects the power relations between managers, coaches, analysts, and athletes.To collect data, a questionnaire has been sent to all elite clubs in Swedish men’s and women’s football. Analytically, the study builds on the perspective of governmentality (Foucault & Faubion, 2002; Walters, 2012), which facilitates an understanding of how governing processes constitute subject positions and the power relations between them (Primus, 2024). This study will analyze what subject positions (i.e., managers, coaches, analysts, and players) and power relations the ‘governmentality of technology’ constitutes in the context of Swedish elite soccer.Data analysis has just started and has so far only focused on the mapping (aim 1). Preliminary findings show that most Swedish elite soccer clubs use GPS, video, and heart rate monitors to track tactical and physiological aspects, respectively. It is mostly the physio or the analyst who collects, interprets, and communicates the data. However, the scope depends significantly on the resources and number of individuals in the coaching staff of the club.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_strmbergjuliusz_2025, title = {Mapping values in sport clubs : towards a conceptual typology for understanding the bettering of grassroots sport governance}, author = {Strömberg, Julius Z. and Fahlén, Josef and Strittmatter, Anna-Maria}, year = {2025}, journal = {European Sport Management Quarterly}, doi = {10.1080/16184742.2025.2582559}, url = {2014125}, language = {eng}, publisher = {Routledge}, keywords = {good governance; sport clubs; modernization; nonprofit governance; sport policy}, abstract = {Research Question: The study aims to offer a typology illustrating sport clubs' common values, and how they influence clubs' potential responses to policy reforms and modernization efforts. Based on a conceptual framework focusing on the roots of modernization and tradition, as well as intrinsic and extrinsic motivation in grassroots sport, we construct a typology of values inherent and embedded in sport clubs.Research Methods: We generated some 600 pages of empirical material from published club handbooks, guidelines, and strategy documents from 21 Norwegian sport clubs. The intertextual analysis was influenced by organizational discourse analysis.Results and Findings: The discursive analysis of sport clubs' official communication reveals four overarching themes underpinning their governance: (a) lifelong activity and community creation; (b) democracy, schooling, and inclusion; (c) voluntarism, local anchoring, and collective understanding; and (d) innovation, professionalism, and communication. Our findings show the variance of values articulated by sport clubs and how they relate to wider traditional, modern, intrinsic, and extrinsic values.Implications: With this study, we can not only conceptualize how sport clubs view modernization efforts embedded in policy initiatives but also better theoretically understand how they would respond to potential reforms. Methodologically, this study provides an alternative approach to the often-quantitative methods on sport club typologies and often-binary golden standards used to measure and implement governance frameworks. For policymakers wanting sport clubs to better their governance, this study offers an understanding of the complexity in which sport clubs operate.}, issn = {1618-4742} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindgrennicklas_2025, title = {Masculine-coded ideals of consuming vegan food : An analysis of Swedish male students’ negotiations of plant-based school meals}, author = {Lindgren, Nicklas and Frödén, Sara}, year = {2025}, journal = {Food, Culture, and Society: an international journal of multidisciplinary research}, pages = {1--26}, doi = {10.1080/15528014.2025.2609242}, url = {2024989}, language = {eng}, publisher = {Routledge}, keywords = {veganism; ecofeminism; school meal; school food; masculinity; animal consumption; meat; climate-denial; sustainability}, abstract = {While a rich body of research links veganism and animal consumption with masculinity, empirical studies connecting masculinity and animal consumption with sustainability are much more limited. To emphasize the environmental consequences of consuming animal products, this study examines upper-secondary male students’ responses to their school’s decision to serve vegan food exclusively. Informed by the concept of vegan ecofeminism and previous research, three main arguments for eating plant-based food have been used to analyze male students’ responses to vegan school food: (1) the contribution to global sustainable development, 2) concern for animal welfare, and (3) improvement of one’s health. In contrast to previous research showing a connection between climate change skeptic opinions and young (often conservative) men, the participants of this study did not express any opinions that could be considered examples of climate change denialism. Instead, the male students’ ideas about their own well-trained and muscular bodies caused resistance to vegan school food.}, issn = {1552-8014}, file = {https://oru.diva-portal.org/smash/get/diva2:2024989/FULLTEXT01.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_deboisesam_2025_1, title = {Masculinities}, author = {de Boise, Sam and Goedecke, Klara and Hearn, Jeff}, year = {2025}, pages = {296--301}, url = {1938769}, language = {eng}, publisher = {Edward Elgar Publishing}, keywords = {gender organisations; management; masculinities; men}, abstract = {The concept of masculinities is used in various ways to describe the behaviors, performances, expectations and construction of ideas of and about men within a given temporal, geographical and social context. Whilst the term masculinity (singular) suggests one dominant norm,  masculinities (plural) indicates that there are different forms and processes. There are several ways of conceptualizing the term. Psychological approaches tend to view masculinities as expressions of individuals’ psyches linked to social norms. Structuralist approaches see them as linked to different configuration of gendered relations within societies whereas constructionist approaches see them as discursive ideals. These approaches are interlinked but how they are studied and theorized differs, depending on researchers’ backgrounds, and all are relevant for understandings of management, managers and managing. } } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_deboisesam_2025_2, title = {Masculinities}, author = {de Boise, Sam and Goedecke, Klara and Hearn, Jeff}, year = {2025}, pages = {296--301}, doi = {10.4337/9781803922065.ch90}, url = {1943825}, language = {eng}, publisher = {Edward Elgar Publishing}, keywords = {hegemonic masculinity; male sex role; leadership; management; masculinities; raewyn connell}, abstract = {This addresses debates on masculinity, masculinities, and management. Starting with an outline of what is meant by the term, masculinities, it discusses the conceptual foundations of theoretical and empirical approaches to the topic in terms of psychoanalysis, sex-role theory, and Marxist and feminist critiques. It moves on to discuss how the term has broadened in recent years, before addressing the confusions and critiques of the term. This ranges from poststructuralist, discursive, and queer critiques. It, finally, highlights various applications of this work on masculinities for the analysis of management, managers, and managing.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_qandeelmais_2025_3, title = {Mass Surveillance and Datafication of People in Occupied Territory : Limitations and Obligations}, author = {Qandeel, Mais}, year = {2025}, url = {1952553}, language = {eng}, keywords = {ai-enhanced surveillance; belligerent occupation; biometrics; ihl} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mohammedomard_2025, title = {Mass Variation Techniques for Damping the Resonance Effect}, author = {Mohammed, Omar D.}, year = {2025}, journal = {Journal of vibration engineering & technologies}, volume = {13}, number = {7}, doi = {10.1007/s42417-025-01997-1}, url = {1992512}, language = {eng}, publisher = {Springer}, keywords = {natural frequency; mass variation; resonance; frequency response; amplitude ratio}, abstract = {Purpose: Studying the system's natural frequencies is crucial to prevent resonance phenomena that can harm both the system and the people around it. Resonance can occur when the system is excited by an applied forced frequency that coincides with the system's natural frequency. Therefore, it is important to avoid running the system at a frequency equal to or close to one of its natural frequencies. However, it is not always possible to have control of the excitation or the applied frequency to avoid matching the system's natural frequencies.Methods: The current article examines two developed techniques, namely the electromagnet-based technique and the water-based technique, for altering the system's natural frequency through mass variation. The electromagnet-based technique is also used with the Tuned Mass Damper TMD, which can be applied for the same purpose.Results: Dynamic modelling is presented, and the amplitude ratios are calculated. Experimental tests are conducted to prove the techniques' applicability. The presented methods demonstrate the potential for avoiding resonance through natural frequency variation, thereby enhancing the safety and reliability of the operating system.Conclusion: The presented methods show the possibility of avoiding resonance via natural frequency. The applied techniques are compared, and their applications are discussed in terms of response and solution applicability.}, issn = {2523-3920} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ohaganlaurenalex_2025_6, title = {Material hauntings : The emotional residue of absent and lost music keepsakes}, author = {O’Hagan, Lauren Alex}, year = {2025}, journal = {Social Sciences and Humanities Open}, volume = {11}, doi = {10.1016/j.ssaho.2025.101603}, url = {2028299}, language = {eng}, publisher = {Elsevier}, keywords = {absence; heritage-as-praxis; loss; material assemblages; materiality of nothing; music keepsakes; rory gallagher}, abstract = {This Short Communication paper presents two case studies of absent and lost music keepsakes and the emotional and spatial chasms they leave behind. Focusing on a misplaced watch and a lost Guinness can that once belonged to Irish blues musician Rory Gallagher, it examines how these objects endure as material hauntings, evoking Gallagher's aura and eliciting feelings of mystery and unease. It argues that their absence foregrounds their material qualities and shows how, even in loss, they function as heritage-as-praxis, accruing meaning through memory and storytelling. Ultimately, the paper reveals how such voids shape emotional landscapes and alternative music histories. © 2025} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ohaganlaurenalex_2025_7, title = {Materialising music worlds : heritage-as-praxis in everyday music objects and vernacular memories}, author = {O’Hagan, Lauren Alex}, year = {2025}, journal = {Cogent Arts and Humanities}, volume = {12}, number = {1}, doi = {10.1080/23311983.2025.2558191}, url = {1999735}, language = {eng}, publisher = {Taylor & Francis}, keywords = {music worlds; material assemblages; heritage-as-praxis; vernacular heritage; music fandom; material culture; rory gallagher; art and visual culture; filmmaking and postproduction; media communication; media and film studies; critical theory; film philosohy}, abstract = {This paper extends Crossley's concept of 'music worlds' by foregrounding the role of material assemblages in shaping collective memory, fan practices and vernacular heritage. Drawing on object-oriented interviews with fans of Irish blues-rock musician Rory Gallagher, it examines how everyday music-related keepsakes mediate four sequential rites of passage in the fan experience: discovering Gallagher's music, seeing him in concert, meeting him and hearing the news of his death. By situating these objects at the centre of analysis, the study shows how they act as vessels of memory and emotion, sustaining heritage-as-praxis through everyday sociocultural practices. In doing so, it demonstrates that studies of music worlds would benefit from a material culture approach, which captures how fragile, unofficial and ageing collections of fan objects complicate their inclusion within authorised heritage frameworks yet remain vital to the construction of alternative, community-based histories of popular music. The paper, therefore, advances theoretical debates on music worlds and heritage-as-praxis while signalling the urgent need to recognise, preserve and critically revalue the overlooked material traces through which fans actively shape and sustain popular music heritage.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_mazurstepan_2025_1, title = {Matrix Gamma Distributions and Related Stochastic Processes}, author = {Mazur, Stepan and Kozubowski, Tomasz J. and Podgorski, Krysztof}, year = {2025}, url = {1975242}, language = {eng} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_kandlerwolfgang_2025, title = {Matrix Matching for Analysis of High Salinity Samples by Inductively Coupled Plasma Mass Spectrometry (ICP-MS)}, author = {Kandler, Wolfgang and Zeiner, Michaela and Krska, Rudolf}, year = {2025}, url = {1936490}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kozubowskitomaszj_2025, title = {Matrix variate gamma distributions with unrestricted shape parameter}, author = {Kozubowski, Tomasz J. and Mazur, Stepan and Podgórski, Krzysztof}, year = {2025}, journal = {Journal of Multivariate Analysis}, volume = {209}, doi = {10.1016/j.jmva.2025.105457}, url = {1961923}, language = {eng}, publisher = {Elsevier}, keywords = {matrix gamma distribution; matrix laplace distribution; singular wishart distribution}, abstract = {Matrix gamma distributions are among the most important matrix-variate laws in multivariate statistical analysis, as they encompass the Wishart distributions - the sample covariance distributions under Gaussianity - and provide a natural model for random covariances in Bayesian multivariate methods. A substantial body of literature explores this class of distributions, traditionally characterized by a shape parameter restricted to the (Gindikin) set i/2, i ∈ 1, . . . , k − 1 ∪ ((k − 1)/2, ∞), where k × k is the dimension of the matrix variate. In this paper, we show that matrix-variate gamma distributions can be naturally extended to allow the entire positive half-line as the domain of the shape parameter. This extension not only unifies the well-known singular Wishart and non-singular matrix-variate gamma distributions but also introduces new singular matrix-variate distributions with shape parameters outside the Gindikin set. While permutation invariance is no longer preserved in the singular, non-Wishart case, and its scaling properties require special treatment, our unified framework leads to new representations that bypass the restrictions of the Gindikin set. We provide several elegant and convenient stochastic representations for matrix-variate gamma distributions, which are novel even in the non-singular case. Notably, we demonstrate that the lower triangular matrix in the Cholesky factorization of a gamma-distributed matrix - whether singular or not - follows a triangular matrix-variate Rayleigh distribution, introducing a new class of matrix-valued variables that extends the classical univariate Rayleigh distribution to the matrix domain. We also briefly address statistical issues and potential applications to non-elliptical multivariate heavy tailed data.}, issn = {0047-259X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_settestefania_2025, title = {Measurement invariance of the Straightforwardly-Worded Social Interaction Anxiety Scale and Associations with life satisfaction among emerging adults attending University in 10 countries}, author = {Sette, Stefania and Coplan, Robert J. and Ooi, Laura L. and Zuffianò, Antonio and Xiao, Bowen and Wong, Quincy J. J. and Rapee, Ronald M. and Oh, Wonjung and Liu, Junsheng and Kim, Yunhee and Kim, Hyoun K. and Kamble, Shanmukh and Greco, Carolina and Dogan, Aysun and Castillo, Karen Noel and Braathu, Nora and Bølstad, Evalill and Bayram Özdemir, Sevgi and Bowker, Julie C.}, year = {2025}, journal = {Journal of Anxiety Disorders}, volume = {116}, doi = {10.1016/j.janxdis.2025.103092}, url = {2014808}, language = {eng}, publisher = {Elsevier}, keywords = {cross-cultural study; life satisfaction; multiple-group factor analysis alignment; s-sias; university students}, abstract = {The aim of the present study was to assess the measurement invariance of the long version of the straightforwardly-worded Social Interaction Anxiety Scale (S-SIAS) across 10 countries and explore links with life satisfaction in a large sample of emerging adults attending university. Participants were N = 4284 university students (Mage = 19.89 years, SD = 1.83; 65 % females) from 10 countries (i.e., Argentina, Australia, Canada, China, India, Italy, South Korea, Norway, Turkey, and the United States), who completed self-report assessments of social anxiety and life satisfaction. Findings from a multiple-group factor analysis alignment method indicated approximate measurement invariance for the S-SIAS across the 10 country sites. University students from Norway reported the highest mean level of social anxiety of all groups, whereas participants from Argentina reported the lowest social anxiety. Results from multigroup regression analysis indicated that social anxiety was negatively associated with life satisfaction in all samples (except for Argentina and Australia, where the life satisfaction measure was not collected), but the strength of the association was stronger in Norway compared to samples from other countries. Results are discussed in terms of the meaning and implication of social anxiety across cultures.}, issn = {0887-6185} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_branzellida_2025, title = {Measurement of bilirubin in cerebrospinal fluid using the oxidase method on automated chemistry system advia XPT}, author = {Branzell, Ida and Lillsunde-Larsson, Gabriella and Samyn, Dieter R. and Pettersson-Pablo, Paul}, year = {2025}, journal = {Practical Laboratory Medicine}, volume = {45}, doi = {10.1016/j.plabm.2025.e00473}, url = {1958378}, language = {eng}, publisher = {Elsevier}, keywords = {bilirubin; cerebrospinal fluid; spectrophotometry; siemens chemistry advia xpt; subarachnoid haemorrhage; clinical laboratory}, abstract = {Background and aim: Evaluate the diagnostic performance of automated, quantitative bilirubin measurement, modified to extend its lower measurement ranges, in cerebrospinal fluid (CSF) using the Siemens analyzer Advia XPT. Results were compared with the gold standard spectrophotometry for diagnosis of subarachnoid haemorrhage (SAH).Method: Eighty clinical samples were analyzed on an Advia XPT, and results were compared to spectrophotometric results using the Agilent Cary 100 bio system. Method performance at low concentrations were evaluated using diluted control material and patient plasma and CSF samples. ROC curve analysis determined a suitable cutoff.Result: Evaluation of low-concentration performance, below 2 mu mol/L on Advia XPT, showed a measurement bias of-1.0 %, and a linear regression equation of y = 0.843x + 0.0351 (R2 of 0.975), describing the relationship between measured and expected concentrations of diluted samples. The coefficient of variation, (CV), was 2.92 % at 0.598 mu mol/L and 26.6 % at 0.161 mu mol/L. Using the outcome of the analysis on Agilent Cary 100 as reference, sensitivity was 100 % and specificity 96 %, employing a cutoff of 0.41 mu mol/L.Conclusion: Quantitative measurement of bilirubin in CSF using the bilirubin oxidase method on the automated Advia XPT platform perform well, with the analysis of low concentrations of bilirubin displaying a high precision and a high concordance with the results of spectrophotometry. These preliminary findings are indicative of the merits of quantitative measurement, that warrants further study of its diagnostic potential as an alternative to the more cumbersome spectrophotometry for diagnosing SAH.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_yuliang_2025_1, title = {Measuring the quality of generative AI systems : Mapping metrics to quality characteristics - Snowballing literature review}, author = {Yu, Liang and Alegroth, Emil and Chatzipetrou, Panagiota and Gorschek, Tony}, year = {2025}, journal = {Information and Software Technology}, volume = {186}, doi = {10.1016/j.infsof.2025.107802}, url = {1985311}, language = {eng}, publisher = {Elsevier}, keywords = {generative ai; genai; large language model; llm; quality characteristics; metric; evaluation}, abstract = {Context: Generative Artificial Intelligence (GenAI) and the use of Large Language Models (LLMs) have revolutionized tasks that previously required significant human effort, which has attracted considerable interest from industry stakeholders. This growing interest has accelerated the integration of AI models into various industrial applications. However, the model integration introduces challenges to product quality, as conventional quality measuring methods may fail to assess GenAI systems. Consequently, evaluation techniques for GenAI systems need to be adapted and refined. Examining the current state and applicability of evaluation techniques for the GenAI system outputs is essential.Objective: This study aims to explore the current metrics, methods, and processes for assessing the outputs of GenAI systems and the potential of risky outputs.Method: We performed a snowballing literature review to identify metrics, evaluation methods, and evaluation processes from 43 selected papers.Results: We identified 28 metrics and mapped these metrics to four quality characteristics defined by the ISO/IEC 25023 standard for software systems. Additionally, we discovered three types of evaluation methods to measure the quality of system outputs and a three-step process to assess faulty system outputs. Based on these insights, we suggested a five-step framework for measuring system quality while utilizing GenAI models.Conclusion: Our findings present a mapping that visualizes candidate metrics to be selected for measuring quality characteristics of GenAI systems, accompanied by step-by-step processes to assist practitioners in conducting quality assessments.}, issn = {0950-5849} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gomezmicaelak_2025_1, title = {Mechanism matters for major vascular injury in children : A Trauma Quality Improvement Program analysis}, author = {Gomez, Micaela K. and Forssten, Maximilian Peter and Wood, Elizabeth C. and Williams, Timothy K. and Forssten, Sebastian Peter and Sarani, Babak and Neff, Lucas P. and Mohseni, Shahin}, year = {2025}, journal = {Journal of Trauma and Acute Care Surgery}, volume = {99}, number = {3}, pages = {397--403}, doi = {10.1097/TA.0000000000004631}, url = {1953150}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, keywords = {pediatric; blunt trauma; gunshot wounds; outcome; vascular injury}, abstract = {BACKGROUND: Trauma is the leading cause of death in pediatric patients, with major vascular injuries significantly worsening outcomes. This study aimed to evaluate the mortality and complication profile of pediatric trauma patients suffering from major vascular injuries as a result of gunshot wounds (GSWs) compared with blunt mechanisms.METHODS: We queried the American College of Surgeons Trauma Quality Improvement Program database from 2013 to 2021 for pediatric (≤12 years old) trauma patients who suffered a major vascular injury as a result of either blunt trauma or a GSW. Patients were excluded if they had a head or face Abbreviated Injury Scale ≥2 or an Abbreviated Injury Scale of 6 in any other region. These groups were examined regarding demographics, clinical characteristics, and in-hospital outcomes. In order to adjust for confounding, Poisson regression models with robust standard errors were employed.RESULTS: After applying the inclusion and exclusion criteria 1,605 patients remained for further analysis. Of these, 18.1% patients (n = 292) suffered a GSW. GSW patients were significantly more injured than blunt trauma patients (Injury Severity Score ≥ 16: 59.6% vs. 33.6%, p < 0.001). GSW patients had significantly higher rates of major intrathoracic as well as femoral vascular injuries, whereas intraabdominal aortic and renal vascular injuries were more common in blunt trauma patients. GSW patients accordingly demonstrated significantly higher rates of in-hospital mortality (21.2% vs. 5.3%, p < 0.001) and overall complications (13.7% vs. 8.4%, p = 0.007). After adjusting for potential confounding, suffering a major vascular injury due to a GSW was associated with an 80% higher rate of mortality (p = 0.013).CONCLUSION: The overall lethality and complication rate for major vascular injury is greater after GSWs than blunt trauma. These findings underscore the importance of firearm injury prevention and provide further insight into the new leading cause of death in children.LEVEL OF EVIDENCE: Therapeutic/Care Management; Level III.}, issn = {2163-0755} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vummaravi_2025, title = {Mechanisms of Proinflammatory Cytokines in the Progression of Neuropsychiatric Disorders}, author = {Vumma, Ravi and Ellsworth, Zachary and Bumford, Kierra and Venizelos, Nikolaos and Montero, Jessica}, year = {2025}, journal = {Journal of Pharmacology and Experimental Therapeutics}, volume = {392}, number = {3}, doi = {10.1016/j.jpet.2024.101049}, url = {1953437}, language = {eng}, publisher = {Elsevier}, issn = {0022-3565} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_leerjonatan_2025_1, title = {Media and food}, author = {Leer, Jonatan and Krogager, S.G.S.}, year = {2025}, pages = {341--345}, doi = {10.4337/9781800887435.00088}, url = {2029743}, language = {eng}, publisher = {Edward Elgar Publishing Ltd.}, keywords = {activism; celebrity; food consumption; gender; social media; sustainability}, abstract = {Mundane life is saturated with media and the amalgamation of everyday practices and digital media re-configures our society and the way we live and eat. In the following, this premise is framed in terms of food set in a Western context. Food media has been around for centuries however, with mediatization and digitalisation the permeation of food in the media has amplified. Thus, food media has diversified, democratised and not least monetized and become a key space for negotiations of ideologies, gender and identity. © Lewis Holloway, Michael K. Goodman, Damian Maye, Moya Kneafsey, Alexandra E. Sexton and Ana Moragues-Faus 2025.} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_aavikkadri_2025, title = {Men, masculinities, and the planet at the end of (M)Anthropocene : Ecological/social/economic/political relations, processes and consequences}, author = {Aavik, Kadri and Hearn, Jeff and Hultman, Martin and Shefer, Tamara}, year = {2025}, url = {2021676}, language = {eng}, publisher = {Taylor & Francis}, keywords = {global; men; anthropocene; planet; masculinities; environment}, abstract = {The articles in this special issue deploy multiple overlapping themes on men and masculinities in relation to, for example: Global South / non-Western contexts (Li, Ncube et al., Smith Khanna); climate change (Swan, Faber & Leer, Hyldig); non-human animals, meat/veganism (Browne, Hyvönen, Dunnett); care, caring masculinities for the environment and planet (Burrell et al., Faber & Leer, Smith Khanna); social movements, activism (Dunnett, Ncube et al., Burrell et al.); and land, water, oceans (Swan, Browne, Ncube et al., Li). There are of course other cross-cutting themes and ways to group the papers, for example: prefigurative politics/creating everyday utopias; resurgence and relationality; individual versus more collective action; negative versus positive action and activism; the local and the global; large-scale and small-scale. In ordering the papers, we decided to prioritise geographical-geopolitical dimensions, moving from China and the Pacific to Africa to South America, then to Australia, Canada and Europe, and ending with global activism.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_aavikkadri_2025_1, title = {Men, masculinities, and the planet at the end of (M)Anthropocene : ecological/social/economic/political relations, processes and consequences}, author = {Aavik, Kadri and Hearn, Jeff and Hultman, Martin and Shefer, Tamara}, year = {2025}, journal = {Norma}, volume = {20}, number = {4}, pages = {254--268}, doi = {10.1080/18902138.2025.2576458}, url = {2016283}, language = {eng}, publisher = {Routledge}, issn = {1890-2138} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wronskimarielouis_2025, title = {Mental and Somatic Conditions in Children With the Broad Avoidant Restrictive Food Intake Disorder Phenotype}, author = {Wronski, Marie-Louis and Kuja-Halkola, Ralf and Hedlund, Elin and Martini, Miriam I. and Lichtenstein, Paul and Lundström, Sebastian and Larsson, Henrik and Taylor, Mark J. and Micali, Nadia and Bulik, Cynthia M. and Dinkler, Lisa}, year = {2025}, journal = {JAMA pediatrics}, volume = {79}, number = {4}, pages = {428--437}, doi = {10.1001/jamapediatrics.2024.6065}, url = {1938300}, language = {eng}, publisher = {American Medical Association (AMA)}, abstract = {IMPORTANCE: Avoidant restrictive food intake disorder (ARFID) is a feeding and eating disorder characterized by limited variety and/or quantity of food intake impacting physical health and psychosocial functioning. Children with ARFID often present with diverse psychiatric and somatic symptoms and therefore consult various pediatric subspecialties. Large-scale studies mapping coexisting conditions are, however, lacking.OBJECTIVE: To characterize the health care needs of youth with ARFID.DESIGN, SETTING, AND PARTICIPANTS: This cohort study used the Child and Adolescent Twin Study in Sweden (CATSS), in combination with inpatient and specialized outpatient clinical diagnoses from the Swedish National Patient Register. Data were collected from July 2004 to April 2020, and data were analyzed from September 2022 to February 2024.EXPOSURE: Using a composite measure derived from parent or guardian reports and register data, children with the broad ARFID phenotype occurring between the ages of 6 to 12 years were identified, as well as children without ARFID. MAIN OUTCOMES AND MEASURES: From more than 1000 diagnostic International Classification of Diseases (ICD) codes, mental and somatic conditions within or across ICD chapters, the number of distinct per-person diagnoses, and inpatient treatment days between participants' birth and 18th birthdays were specified (90 outcomes). Hazard ratios (HRs) and incidence rate ratios (IRRs) were calculated.RESULTS: Of 30 795 CATSS participants, a total of 616 children (2.0%) with the broad ARFID phenotype occurring between the ages of 6 to 12 years were identified, and 30 179 children without ARFID were identified. Of 616 children with ARFID, 241 children were female (39.1%). Relative risks of neurodevelopmental, gastrointestinal, endocrine or metabolic, respiratory, neurological, and allergic disorders were substantially increased in children with ARFID (eg, autism: HR, 9.7; 95% CI, 7.5-12.5; intellectual disability: HR, 10.3; 95% CI, 7.6-13.9; gastroesophageal reflux disease: HR, 6.7; 95% CI, 4.6-9.9; pituitary conditions: HR, 5.6; 95% CI, 2.7-11.3; chronic lower respiratory diseases: HR, 4.9; 95% CI, 2.4-10.1; and epilepsy: HR, 5.8; 95% CI, 4.1-8.2). ARFID was not associated with elevated risks of autoimmune illnesses and obsessive-compulsive disorder. Children with ARFID had significantly more distinct mental diagnoses (IRR, 4.7; 95% CI, 4.0-5.4) and longer hospital stays (IRR, 5.5; 95% CI, 1.7-17.6) compared with children without ARFID. Children with ARFID were diagnosed with a mental condition earlier than children without ARFID. No sex-specific differences emerged.CONCLUSIONS AND RELEVANCE: This cohort study yields the broadest and most detailed evidence of coexisting mental and somatic conditions in the largest sample of children with ARFID to date. Findings suggest a complex pattern of health needs in youth with ARFID, underscoring the critical importance of attention to the illness across all pediatric specialties.}, issn = {2168-6203} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_leissnerphilip_2025, title = {Mental health status and quality-of-life after an acute myocardial infarction with non-obstructive coronary arteries or takotsubo syndrome : A systematic review}, author = {Leissner, Philip and Olsson, Erik M. G. and Rondung, Elisabet and Sundelin, Runa and Spaak, Jonas and Ulvenstam, Anders and Nordenskjöld, Anna M. and Kövamees, Lena and Lyngå, Patrik and Held, Claes and Tornvall, Per and Humphries, Sophia}, year = {2025}, journal = {European Journal of Preventive Cardiology}, doi = {10.1093/eurjpc/zwaf101}, url = {1950524}, language = {eng}, publisher = {Oxford University Press}, keywords = {minoca; mental health; quality of life; systematic review; takotsubo syndrome; after event}, abstract = {BACKGROUND: Myocardial infarction with non-obstructive coronary arteries (MINOCA) and takotsubo syndrome (TS) are both characterised by lack of significant coronary artery stenoses and a higher prevalence of mental health disorders preceding the event. Currently, little is known about their pathological aetiologies and subsequent treatment plans, giving cause for concern among those affected. The objective of this review is to provide a comprehensive overview of mental health status and quality of life (QoL) in MINOCA- and TS-patients after the acute event, compared to both cardiac and non-cardiac populations, and over time.METHODS: A systematic search was conducted via Cochrane Library, CINAHL, PyschINFO, PubMed, ASSIA, Web of Science, Scopus and Embase from inception to May 2024. The review was registered in PROSPERO and methods, and results were reported in accordance with the PRISMA guidelines. Quality assessment and risk of bias were evaluated using the Newcastle-Ottawa Scale for cross-sectional and cohort studies.RESULTS: Sample sizes ranged from 13 to 5,322 participants. The risk of bias was high in 18/28, medium in 7/28, and low in 3/28 studies. Across the symptoms assessed, MINOCA- and TS-patients reported worse mental health status or QoL than non-cardiac groups in 10/13 studies, and cardiac groups in 10/20 studies. Investigating change over time, 1/5 studies found deteriorating mental health status, 3/5 reported improved mental health status or QoL and 1/5 reported no change in MINOCA- and TS-patients.CONCLUSIONS: Patients with MINOCA or TS seem to have worse mental health status and QoL after the acute event than non-cardiac individuals, but it is yet difficult to conclude whether mental distress and QoL are equal or worse compared to CHD-patients. There is no convincing evidence that mental health status or QoL of MINOCA- and TS- patients naturally improve over time after the acute event. Among the studies evaluated, risk of bias was high. More high-quality studies are needed, investigating mental health status and QoL among MINOCA- and TS-patients.}, issn = {2047-4873} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_uvhagenlena_2025, title = {Mental well-being in Swedish adolescents 2014-2023 : A repeated population-based cross-sectional study focusing on temporal variations and differences between groups}, author = {Uvhagen, Lena and Gustafsson, Johanna and Söderqvist, Fredrik}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {5}, doi = {10.1371/journal.pone.0323963}, url = {1967351}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {Mental well-being is more than merely the absence of mental illness; it is a multidimensional concept that includes both emotional and functional well-being, which are valuable resources during adolescence. In order to develop relevant interventions and policies to strengthen adolescent mental health, a continuous monitoring of the population well-being becomes important. The aim of the study was to examine the level, distribution, and changes in mental well-being over time in a Swedish adolescent population. Current study is based on four waves (2014-2017-2020-2023) of a cross-sectional student survey (N = 16288, Mage = 16.23). The outcome was measured with the Mental Health Continuum Short Form. Ten explanatory factors were chosen to examine differences in mental well-being in the study population: Grade, Sex, Sexual orientation, Socioeconomic status, Country of birth, Visual, Hearing or Mobility impairment, Specific learning disorder and Neurodevelopmental disorder. Differences in mental well-being between groups as well as temporal trends were examined and evaluated through statistical testing and hierarchical multiple linear regressions modeling. Girls, non-heterosexual adolescents, and adolescents with low socioeconomic status or impairments have lower levels of mental well-being than boys, heterosexual adolescents, and adolescents with higher socioeconomic status or without impairments, respectively. A deterioration in mental well-being is seen over time for several groups; however, results of the multivariable analysis indicates that the deterioration is mainly an effect of sex and the significant decline in mental well-being seen among girls. The most significant factor for explaining the variation in mental well-being in this study is socioeconomic status. This study elucidates temporal changes and differences in levels of mental well-being between social groups in the adolescent population. The overall differences are small, but their potential implications for public health warrant careful consideration since they concern a significant part of the population. The results underscore the imperative of promoting mental well-being in adolescents, particularly among vulnerable groups.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_21, title = {Mervärdesskatt vid beskattningsbara transaktioner till anställda – nytt ställningstagande från Skatteverket}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031790}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 1 april 2025 kom Skatteverkets ställningstagande ”Beskattningsbara transaktioner till anställda, mervärdesskatt”. Ställningstagandet beaktar Högsta förvaltningsdomstolens domar om netto- och bruttolöneavdrag. Professor Eleonor Kristoffersson diskuterar ställningstagandet.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_delucamaurizio_2025, title = {Meta-analysis of randomized controlled trials for the development of the International Federation for Surgery of Obesity and Metabolic Disorders-European Chapter (IFSO-EC) guidelines on multimodal strategies for the surgical treatment of obesity}, author = {De Luca, Maurizio and Belluzzi, Amanda and Angrisani, Luigi and Bandini, Giulia and Becattini, Barbara and Bueter, Marco and Carrano, Francesco Maria and Chiappetta, Sonja and Cohen, Ricardo V. and Copaescu, Catalin and Di Lorenzo, Nicola and Emous, Marloes and Felsenreich, Daniel Moritz and Fried, Martin and Himpens, Jacques and Iannelli, Antonio and Navarra, Giuseppe and Nienhuijs, Simon and Olmi, Stefano and Parmar, Chetan and Prager, Gerhard and Pujol-Rafols, Juan and Ragghianti, Benedetta and Ribeiro, Rui and Ruiz-Úcar, Elena and Sakran, Nasser and Salminen, Paulina and Scoccimarro, Daniele and Stenberg, Erik and Stier, Christine and Taskin, Halit Eren and Puy, Ramón Vilallonga and Monami, Matteo}, year = {2025}, journal = {Diabetes, obesity and metabolism}, volume = {27}, number = {6}, pages = {3347--3356}, doi = {10.1111/dom.16352}, url = {1950760}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {glp‐1 analogue; bariatric surgery; meta‐analysis; obesity therapy}, abstract = {BACKGROUND: Randomized, controlled trials (RCTs) comparing the effectiveness of metabolic bariatric surgery (MBS) in addition to one or more treatment interventions for obesity (i.e., lifestyle structured interventions-LSI, medical therapy-MT, obesity management medication-OMM or endobariatric procedures-EP) are lacking. This study aims to assess the effectiveness of multiple simultaneous (before or immediately after MBS) interventions for treating obesity.METHODS: We performed a meta-analysis including all RCTs enrolling patients undergoing different MBS procedures add-on to other anti-obesity strategies (LSI, MT, OMM or ES) versus MBS alone, with a duration of at least 6 months. The primary outcome was BMI at the end-point; secondary end-points included percentage total and excess weight loss (%TWL%, and EBWL%), total weight loss (TWL), fasting plasma glucose (FPG), HbA1c, surgical and non-surgical severe adverse events (SAE), mortality, remission of type 2 diabetes, hypertension, dyslipidemia and health-related quality of life (HR-QoL).RESULTS: A total of 25 RCTs were retrieved. The addition of either OMM (i.e., liraglutide) or EP (i.e., intragastric balloon-IB, endosleeve-ES) to MBS was associated with a significantly lower BMI at the end-point (p = 0.040). The addition of liraglutide only to MBS was associated with a greater %EWL%, but not %TWL and TBWL (p = 0.008). Three trials evaluated end-point HbA1c, showing a significant reduction in favour of liraglutide as an add-on therapy to MBS (p = 0.007). There was no mortality.CONCLUSIONS: MBS combined with non-surgical approaches appears more effective than MBS alone in reducing BMI. Further RCTs on combined therapies to MBS for severe obesity are needed to enhance the tailoring of treatment for severe obesity.}, issn = {1462-8902} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_latifalimuatasem_2025, title = {Metabolic and Resistance Mechanisms of Pseudomonas oleovorans to Biocides in Construction Materials and Industrial Products}, author = {Latif Ali, Muatasem}, year = {2025}, url = {1928203}, language = {eng}, publisher = {Örebro University}, abstract = {The thesis investigates the resistance mechanisms of Pseudomonas oleovorans strains, with an overarching goal of exploring biocide-free alternatives in construction materials and developing efficient formulations with minimal biocide content. The research focuses on the industrially significant P4A isolate, offering a detailed analysis of its unique characteristics compared to the reference strain 1045. Key findings reveal the superior resistance and tolerance of P4A to standard biocides commonly used in industrial coatings, such as BIT and CMIT, as demonstrated through minimum inhibitory concentration (MIC) analysis.Whole genome sequencing (WGS) was employed to explore the genetic basis of biocide resistance. While no specific resistance genes or mutations aligned with existing databases, notable genomic differences suggest potential genetic contributors to antimicrobial resistance. The study also highlights the role of Serine/Threonine protein kinases in bacterial adaptation, with mutations in these kinases influencing survival and metabolic pathways.Metabolic profiling provided insights into the effects of biocide exposure on bacterial metabolism, identifying changes in key metabolites such as tetradecenoic acid, 5-Hydroxyindole-3-acetic acid (5-HIAA), and amino acids. Pathway analysis revealed significant alterations in stress response, energy generation, and protein synthesis pathways, with a specific focus on peptidoglycan biosynthesis in the biocide-resistant strain P4A.Additionally, the thesis examines the emissions of volatile organic compounds (VOCs) from industrial products treated with biocides and biocide-free alternatives. The findings demonstrate that both biocide-free and traditionally biocide-preserved products effectively protect against microbial contamination. However, while traditional biocide-treated products may exhibit slightly higher VOC emissions, these emissions are more significantly influenced by raw materials, such as solvents and plasticizers, rather than biocides alone.Biocides were shown to contribute substantially to the long-term durability and microbial protection of products. By selecting low-VOC biocides and optimizing formulations, manufacturers can achieve a balance between microbial efficacy and environmental impact. The results indicate that biocide-free products offer notable environmental advantages, while biocide-preserved products remain crucial for ensuring microbial safety in industrial applications.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vujasinovicmiroslav_2025, title = {Metabolic Dysfunction-Associated Steatotic Liver Disease and Pancreatic Disease : A Population-Based Nationwide Cohort and Sibling-Controlled Study}, author = {Vujasinovic, Miroslav and Ebrahimi, Fahim and Roelstraete, Bjorn and Bergman, David and Sun, Jiangwei and Sadr-Azodi, Omid and Löhr, J. -Matthias and Ludvigsson, Jonas F.}, year = {2025}, journal = {United European Gastroenterology journal}, volume = {13}, number = {2}, pages = {247--256}, doi = {10.1002/ueg2.12761}, url = {1935266}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {acute pancreatitis; chronic pancreatitis; metabolic dysfunction-associated steatotic liver disease; pancreatic cancer}, abstract = {Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) has been linked to pancreatic diseases, but evidence from population-based studies with liver histology is lacking.Aims and methods: In this population-based cohort including all Swedish adults (n = 8563) with biopsy-proven MASLD, we aimed to investigate incidences of pancreatic diseases compared with matched reference individuals from the general population (n = 38,858) and full siblings (n = 6696). Using Cox proportional hazard models, we calculated multivariable adjusted hazard ratios (aHRs) and confidence intervals (CIs).Results: We documented 359 incidents of pancreatic diseases in MASLD patients and 880 events in matched reference individuals, resulting in an incidence rate difference of 1.54 (95% CI, 1.25-1.84). The relative risk of pancreatic disease was highest in the first two years after MASLD diagnosis (aHR, 2.19 [95% CI, 1.92-2.50), but remained statistically significant increased even up to ten years [aHR, 1.60 (95% CI, 1.38-1.85)]. The most common pancreatic disease in individuals with MASLD was acute non-biliary pancreatitis (1.44 vs. 0.44 events/1000 PY), followed by chronic pancreatitis (0.54 vs. 0.12/1000 PY) and pancreatic cancer (0.88 vs. 0.47/1000 PY). We documented 130 versus 344 pancreas-related deaths among individuals with MASLD and their matched comparators, yielding an absolute risk difference of 0.51/1000 PY and an aHR of 2.41 (95%CI = 1.95-2.97). The findings were consistent in sibling-controlled analyses with an aHR of 2.21 (95%CI = 1.69-2.90).Conclusions: MASLD was associated with significantly higher rates of acute and chronic pancreatitis of predominantly non-biliary origin, as well as an increased risk of pancreatic cancer and pancreas-related mortality.}, issn = {2050-6406} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_louwaegeheidi_2025, title = {Metabolic rate and energy requirements by indirect calorimetry versus predictive formulas in mechanically ventilated patients on full very high protein-to-energy polymeric formula : A retrospective study}, author = {Louwaege, Heidi and Boeykens, Kurt and De Waele, Elisabeth and Beeckman, Dimitri and Torsy, Tim}, year = {2025}, journal = {Clinical Nutrition ESPEN}, volume = {69}, pages = {188--195}, doi = {10.1016/j.clnesp.2025.07.012}, url = {1983538}, language = {eng}, publisher = {Elsevier}, keywords = {enteral nutrition; indirect calorimetry; mechanical ventilation; obesity; protein intake; resting energy expenditure}, abstract = {BACKGROUND & AIMS: In ventilated critically ill patients, both overfeeding and underfeeding can be harmful. Determining energy expenditure is challenging due to various factors. Accurate estimation of nutritional requirements is essential for optimal care. This study compared resting energy expenditure in patients on full-dose high protein-to-energy tube feeding, using indirect calorimetry (IC) and the Roza & Shizgal (R&S) formula. It also examined the effects of sex, age, BMI, primary diagnoses, and non-intentional energy intake, and assessed adherence to European Society for Clinical Nutrition and Metabolism guidelines on protein intake. METHODS: A retrospective cohort study included 178 ventilated ICU patients who received ≥7 days of full-dose high-protein enteral tube feeding between June 2019 and December 2022. IC was compared to the R&S formula, and 24-hour nutritional intake data, including non-intentional sources, were analysed. Multivariate regression identified predictors of energy expenditure differences.RESULTS: A significant difference of -146.64 kcal (SD = 276.38) was found between measured and estimated resting energy expenditure, with severe or morbid obesity and COVID-19 pneumonia as significant predictors. This difference increased when non-intentional energy intake in the preceding 24 hours was considered (M = -514.51; SD = 326.37). When excluding non-intentional energy intake, patients achieved the ESPEN daily protein target of ≥1.3 g/kg actual or adjusted body weight/day, with averages of 1.3 to 1.5 g/kg using both indirect calorimetry and the Roza & Shizgal formula.CONCLUSION: The Roza & Shizgal formula for estimating resting energy expenditure can overestimate or underestimate, so caution is needed, especially in severely to morbidly obese patients. Monitoring energy intake is important, particularly in tube feeding. Protein targets per international guidelines are generally met, except in patients with high non-intentional energy intake.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_soopmattias_2025, title = {Metabolic Responses to Surgical Stress}, author = {Soop, Mattias and Ljungqvist, Olle}, year = {2025}, journal = {Clinical Nutrition ESPEN}, volume = {67}, pages = {178--183}, doi = {10.1016/j.clnesp.2025.02.021}, url = {1946263}, language = {eng}, publisher = {Elsevier} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_oresicmatej_2025, title = {Metabolome informs about the chemical exposome and links to brain health}, author = {Oresic, Matej and Karu, Naama and Zhao, Haoqi Nina and Moseley, Arthur and Hankemeier, Thomas and Wishart, David S. and Dorrestein, Pieter C. and Fiehn, Oliver and Hyötyläinen, Tuulia and Daouk, Rima Kaddurah}, year = {2025}, journal = {Environment International}, volume = {203}, doi = {10.1016/j.envint.2025.109741}, url = {1994057}, language = {eng}, publisher = {Elsevier}, keywords = {alzheimer’s disease; brain health; chemical exposure; environmental exposure; exposome; metabolomics}, abstract = {The metabolome is an intermediate phenotype, summarizing the profile of all small molecules (<1.5 kDa) in biospecimens. The metabolome provides a readout for the net influence of the chemical exposome, diet, gut microbiome, and genome on human health. Metabolic changes observed in exposome studies may thus provide clues about adverse outcome pathways related to cancer, diabetes, heart disease, cognitive impairment and other neurological conditions such as Alzheimer's disease (AD). Whilst the number of human cohort studies including both metabolomic and exposomic profiles is increasing, they are particularly limited in the domain of neurological conditions. Environmental exposures and chemical toxicants are known to have significant effects on the brain, gut microbiome, and gut-brain axis. Environmental chemicals of greatest interest include bisphenols, phthalates, persistent organic pollutants such as polychlorinated biphenyls (PCBs) and per- and poly-fluoroalkyl substances (PFAS), heavy metals, chemicals from household products and pesticides/herbicides; all of which may increase the risk of AD as they impact relevant biochemical mechanisms, especially with chronic exposure. In this review we describe how the chemical exposome can be assessed, including the approach our consortium is taking in the context of AD. Further, we review the current evidence about the impact of the chemical exposome on cognition as well as its influence on the risk and pathogenesis of AD. Finally, we highlight our approach to study the exposome in AD as part of large national and international collaborative efforts on the topic.}, issn = {0160-4120} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_guptashashank_2025_1, title = {Metabolomic and transcriptomic insights into gender-specific PFAS effects on liver disease}, author = {Gupta, Shashank and Jamialahmadi, Oveis and Mancina, Rosellina and Hyötyläinen, Tuulia and Romeo, Stefano and Oresic, Matej}, year = {2025}, journal = {Journal of Hepatology}, volume = {82}, number = {Suppl. 1}, pages = {S112--S112}, url = {1972880}, language = {eng}, publisher = {Elsevier}, abstract = {Background and aims: Per- and polyfluoroalkyl substances (PFAS) are emerging environmental pollutants linked to metabolic disorders, including metabolic dysfunction-associated steatotic liver disease (MASLD). This study investigates the associations between PFAS exposure and MASLD progression, focusing on lipidomic, metabolomic, and transcriptomic biomarkers, functional pathways, and gender-specific responses.Method: Metabolomic and lipidomic analyses were performed to examine changes in metabolite and lipid composition across steatosis grades (0–3) and between MASH-positive and MASH-negative samples. Transcriptomic data were analyzed using weighted gene co-expression network analysis (WGCNA), with KEGG pathway enrichment for functional insights. Mediation analysis explored whether specific metabolites mediated the association between PFAS exposure and steatosis.Results: Lipidomic analysis revealed significant shifts in lipidcomposition with steatosis severity, including increased TG-SFA and TG-MUFA levels in MASH-positive samples and decreased phosphatidylinositol and phosphatidylcholine levels. Gender-specific transcriptomic analysis using WGCNA identified significant modules in both females and males. These modules were significantly negatively correlated with pathways, including arginine biosynthesis, amino acid metabolism, and other related processes in both genders. Metabolomics analysis supported these findings, identifying metabolites negatively correlated with MASLD progression enriched in similar pathways, implicating a disruption in amino acid metabolism with disease progression. Positively correlated transcriptomic modules in females were linked to cell cycle, steroid biosynthesis, and fatty acid metabolism. Furthermore, significant positive correlations were observed between PFAS compounds (e.g., PFUnDA, PFDoDA) and lipids such as phosphatidylinositol, while acylcarnitines showed negative correlations. Mediation analysis showed that specific metabolites partially mediated the relationship between PFAS exposure and steatosis. Phosphatidylinositol mediated the effect of PFHxA ( p = 0.002), TG-SFA mediated PFHpA’s effect ( p = 0.028), and lactosylceramide (Laccer) mediated PFHpA’s effect ( p = 0.004).Conclusion: This study provides insights into the molecular mechanisms linking PFAS exposure to MASLD progression, high-lighting disrupted amino acid and lipid metabolism and gender-specific responses. Identifying specific metabolites as mediators highlights new targets for addressing PFAS-related liver diseases.}, issn = {0168-8278} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_salimosame_2025, title = {Metacognitive therapy for insomnia : An open cohort study on clinical outcomes and the role of cognitive-attentional syndrome factors in insomnia}, author = {Salim, Osame and Bauducco, Serena and Norell, Annika and Callesen, Pia}, year = {2025}, journal = {Sleep medicine: X}, volume = {10}, doi = {10.1016/j.sleepx.2025.100153}, url = {2006250}, language = {eng}, publisher = {Elsevier}, keywords = {insomnia; metacognitive; metacognitive therapy; open trial}, abstract = {BACKGROUND: Insomnia is a common and distressing disorder. Evidence suggests that metacognitive beliefs and maladaptive strategies, such as worry and rumination, may maintain insomnia.OBJECTIVES: This study is the first trial of metacognitive therapy (MCT) for insomnia. It aimed to evaluate the effects of MCT on insomnia severity and examine how cognitive-attentional syndrome (CAS) components predict these changes.METHODS: An uncontrolled open cohort trial was conducted with 31 participants in a clinic setting. Participants received up to ten MCT sessions and completed weekly measures of insomnia severity, anxiety, depressive symptoms, and metacognitive beliefs, including maladaptive strategies. The primary outcome was remission status from pre-to post-treatment. Associations between components of the cognitive-attentional syndrome (CAS) and insomnia severity were examined using a mixed model. Follow-up data were collected at 3, 6, and 12 months.RESULTS: At post-treatment, 57 % of participants met remission criteria and 67 % scored below the clinical cut-off. Within-group effect sizes were large for the Insomnia Severity Index (Hedges' g = 1.64) and moderate for anxiety (HADS-A, g = 0.67) and depression (HADS-D, g = 0.72). Among those providing follow-up data, 87.5 % remained at or further improved their insomnia symptoms by their last assessment. Moreover, both between-person averages and within-person changes in maladaptive CAS strategies significantly predicted ISI scores, whereas only within-person changes in CAS-negative metacognitions reached significance.CONCLUSIONS: These preliminary findings indicate that metacognitive therapy (MCT) shows promise as an intervention for insomnia. However, large-scale, controlled trials are necessary to further evaluate its clinical utility for this condition.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zeinermichaela_2025_5, title = {Metal Uptake by Birches and Scots Pines Grown on a Porcelain Landfill}, author = {Zeiner, Michaela and Sjöberg, Viktor and Olsman, Helena}, year = {2025}, journal = {Molecules}, volume = {30}, number = {10}, doi = {10.3390/molecules30102196}, url = {1959685}, language = {eng}, publisher = {MDPI}, keywords = {bioaccumulation; lidköping (sweden); metal uptake; porcelain brownfield; scots pine; silver birch}, abstract = {Potentially toxic elements (PTEs) have steadily become a serious environmental problem, especially regarding brownfields chosen for reuse, e.g., as a residential area. “Norra Hamnstaden” in Lidköping (Sweden) has a long history of industrial activity, including porcelain production with the resultant industrial waste deposited close by resulting in elevated levels of metals used for porcelain glazes, especially lead. To estimate the bioavailability of twelve PTEs (As, Ba, Pb, Cd, Co, Cu, Cr, Mn, Mo, Ni, V, Zn), their uptake by birches (Betula pendula) as well as Scots pines (Pinus sylvestris) was investigated through analyzing their leaves. Sampling was carried out on five trees once per month in the period from May to August. Different uptake patterns were observed for birches and pines, for the latter even varying with age. The birch samples showed higher contents of nickel, cobalt, molybdenum, and lead compared to the reference trees. Also, the pine needles had elevated lead levels, although by a lower factor. Birch leaves revealed surprising patterns of elevated element bioaccumulation factors, with barium reaching up to eight, offering the possibility to limit analyses to plant material for risk assessments instead of soil analysis.}, issn = {1431-5157} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_valachisantonis_2025, title = {Metastatic triple-negative breast cancer - current treatment strategies in the Nordics : a modified Delphi study}, author = {Valachis, Antonis and Karihtala, Peeter and Geisler, Jürgen and Tuxen, Malgorzata K.}, year = {2025}, journal = {Acta Oncologica}, volume = {64}, pages = {349--357}, doi = {10.2340/1651-226X.2025.42733}, url = {1942980}, language = {eng}, publisher = {Taylor & Francis}, keywords = {mtnbc; delphi method; treatment guidelines; nordics}, abstract = {BACKGROUND AND PURPOSE: This study aimed to assess current treatment strategies for metastatic triple-negative breast cancer (mTNBC) and the perceptions of clinical experts in Sweden, Denmark, Norway, Finland, and Iceland, comparing them to international guidelines to provide insights into how these therapies are implemented and adapted to national Nordic guidelines.METHODS: A three-round modified Delphi method was followed with consensus defined as 70% agreement. A steering committee selected 20 experienced oncologists as panellists and developed the questionnaires. Questions included items related to treatment preferences in different treatment lines with different clinical scenarios in mTNBC patients.RESULTS: In the first round, eight out of 33 questions on clinical treatment reached consensus with 14 out of 27 in the second round reaching consensus. In round three, eight out of eight questions reached consensus. The preferred treatment for mTNBC patients with PD-L1 positive was checkpoint inhibitors (CPI) in combination with chemotherapy. For patients with germline BRCA mutation and PD-L1 negative disease, PARP-inhibitors were preferred as 1L and sacituzumab govitecan (SG) in both 2L and later lines. Disagreement was observed for chemotherapy in later lines where evidence is sparse or lacking.INTERPRETATION: The high level of consensus for new treatment strategies, such as CPI and PARP-inhibitors in 1L and SG in 2L or later lines, in comparison with the limited consensus for older treatments, such as chemotherapy, may reflect the growing academic evidence for different treatment strategies. Understanding the treatment patterns across different countries contributes to gaining consensus on the upcoming therapeutic advances.}, issn = {0284-186X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_skarinn_2025, title = {MGMT PROMOTER METHYLATION STATUS FOR GLIOBLASTOMA : DETERMINATION OF THE CLINICALLY RELEVANT CUT-OFF VALUE FOR TREATMENT PREDICTION}, author = {Skarin, N. and Hallbeck, M. and Werlenius, K. and Rohan, Z. and Sandström, M. and Turányi, E. and Löfgren, David and Strandeus, M. and Tavelin, B. and Malmström, A.}, year = {2025}, journal = {Neuro-Oncology}, volume = {27}, number = {Suppl. 3}, pages = {iii125--iii126}, doi = {10.1093/neuonc/noaf193.420}, url = {2007620}, language = {eng}, publisher = {Oxford University Press}, abstract = {BACKGROUND: Methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter is a predictive factor for glioblastoma (GBM) treated with alkylating agents, such as Temozolomide (TMZ). It correlates with increased survival in GBM patients with MGMT promoter methylated tumours. For methylation specific PCR, used in several trials, the clinically relevant cut-off has previously been defined. However, to date there is no consensus regarding the optimal analytical method for the clinic or relevant cut-off value for the chosen method.MATERIAL AND METHODS: Glioma patients from five university hospitals in Sweden with MGMT test results using the same pyrosequencing kit analysing four CpGs (Qiagen) were identified. From this cohort patients diagnosed with GBM and reported to have received concomitant chemo-radiotherapy with TMZ (CCRT) were selected from the Swedish quality registry for primary brain tumours (SQR) together with prognostic factors. Quantitative MGMT methylation status in percent was obtained from the departments of pathology, as the mean of the four CpGs clinically used, and the results from each separate CpG will be provided. Both the mean and separate CpGs will be linked to survival and prognostic factors. The clinically relevant cut-off will be calculated at a 50% probability to be unmethylated. ROC analysis will be performed for an optimal cut-off supervised by overall survival (OS).RESULTS: MGMT results from 2133 patients were identified. Among these, 510 patients were reported to have received CCRT with TMZ. They had available data regarding obtained treatment including received dose of radiotherapy (RT) and had been diagnosed as GBM, all but 22 molecularly confirmed. Of these, 121 patients had received 40Gy hypofractionated RT, 379 patients ≥50Gy, of which 368 patients had received 60Gy. Ten patients who received <40Gy are excluded from further analysis. Hence, a total of 500 patients are included in the final analysis. An optimal cut-off for unmethylated MGMT using multiple discriminant analysis will be proposed after receiving data regarding prognostic factors: age, performance status, type of surgery and MGMT promoter methylation status of the individual CpGs. A grey zone will also be defined. An updated analysis will be presented.CONCLUSION: In this study we will define the clinically relevant cut-off, and grey zone, when using the pyrosequencing kit analysing four CpGs to determine the MGMT methylation status. Hence, enabling a better treatment prediction for alkylating agents, mainly TMZ, in GBM patients, enhancing individualized treatment. It also enables inclusion of patients in future first line clinical trials omitting TMZ for patients with truly unmethylated MGMT.}, issn = {1522-8517} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vatnsimensvendsen_2025, title = {Microbial Patterns in Newly Diagnosed Inflammatory Bowel Disease Revealed by Presence and Transcriptional Activity-Relationship to Diagnosis and Outcome}, author = {Vatn, Simen Svendsen and Hansen, Simen Hyll and Tannæs, Tone Møller and Brackmann, Stephan and Olbjørn, Christine and Bergemalm, Daniel and Keita, Åsa, V and Gomollon, Fernando and Detlie, Trond Espen and Kalla, Rahul and Satsangi, Jack and Jahnsen, Jørgen and Vatn, Morten Harald and Halfvarson, Jonas and Hov, Johannes Roksund and Ricanek, Petr and Moen, Aina E. F.}, year = {2025}, journal = {Clinical and Experimental Gastroenterology}, volume = {18}, pages = {103--119}, doi = {10.2147/CEG.S504459}, url = {1963298}, language = {eng}, publisher = {Dove Medical Press}, keywords = {microbiota; rna; dna; ibd; biomarkers}, abstract = {Background: As part of the IBD Character initiative, we examined an inception cohort and investigated mucosal microbiota composition and transcriptional activity in relation to clinical outcomes.Methods: A cohort of 237 individuals were included from five countries: Crohn's disease (CD, n = 72), ulcerative colitis (UC, n = 57), symptomatic non-IBD controls (SC, n = 78) and healthy controls (HC, n = 30). Rectal/colonic biopsies were obtained at inclusion, and DNA and RNA were extracted from the same biopsy and examined by sequencing the 16S rRNA V4 region.Results: Beta diversity measurements separated IBD from both HC and SC. IBD and SC exhibited reduced intra-individual diversity compared with HC. When comparing taxonomy at DNA and RNA level, six bacteria were found to differ in abundance and/or transcriptional activity between IBD and symptomatic control, while there were 14 and three between symptomatic control and CD and UC, respectively. A limited number of bacterial taxa were responsible for the largest difference between presence and activity, separating patients and controls. Multiple bacterial taxa were associated with treatment escalation in both UC and CD. Machine-learning models separated IBD from symptomatic controls and treatment escalators from non-escalators (AUC >0.8). However, the differential effects were mainly driven by clinical biomarkers, such as f-calprotectin, s-albumin, and b-hemoglobin.Conclusion: Differences between presence and transcriptional activity were found among multiple taxa when assessing 16S rRNA at DNA and RNA level. Symptomatic controls were more similar to the IBD patients compared to HC. The analyses suggest that the mucosal microbiota carries a moderate diagnostic and predictive potential, outcompeted by f-calprotectin.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_perssoncamilla_2025, title = {Micro-CT analysis of creased and folded multilayer cardboard}, author = {Persson, Camilla and Karlsson, Patrik and Korin, Christer and Biel, Anders and Stigh, Ulf and Vomhoff, Hannes and Nygårds, Mikael and Barbier, Christophe and Tryding, Johan}, year = {2025}, journal = {Nordic Pulp & Paper Research Journal}, doi = {10.1515/npprj-2024-0077}, url = {1963789}, language = {eng}, publisher = {Walter de Gruyter}, keywords = {microscopic studies; delamination; particles; cartonboard; paperboard}, abstract = {Micro-CT analysis of experimentally creased and folded multilayer cardboards reveals insights into how the material deformation due to the creasing and folding process of cardboard impact the material concerning delaminations and position of broke particles. Delaminations were found in various locations and varied in size from just under a tenth of a millimeter to up to four times the thickness of the cardboard. The particles varied in size, ranging from a few micrometers to slightly larger than the cardboard thickness. Characteristic dimensions for the creased and folded cardboard were measured for selected cross sections. The differences in characteristic dimensions for the cross sections among the samples were typically a few hundredths of a millimeter. There are differences between cross-sections that are a few hundredths of a millimeter apart.}, issn = {0283-2631} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rodejulia_2025, title = {Micro-encapsulation differentially impacts probiotic effects on brain structure and function in an elderly population : A randomised placebo-controlled trial}, author = {Rode, Julia and Hutchinson, Ashley N. and Chatzopoulou, Myrto and Bleiel, Sinéad B. and Gebresenbet, Rediet Fikru and Andersson, Linda and Persson, Jonas and Daillère, Romain and Beitz, Benoît and Abdallah, Bouthaina Ben and Tingö, Lina and Bergh, Cecilia and Brummer, Robert Jan}, year = {2025}, journal = {Brain, behavior, and immunity}, volume = {130}, doi = {10.1016/j.bbi.2025.106113}, url = {1999715}, language = {eng}, publisher = {Elsevier}, keywords = {bdnf; brain function; cognition; encapsulation; functional magnetic resonance imaging; gaba; gamma-aminobutyric acid; gut microbiota; mrs; magnetic resonance spectroscopy; mood; networks; neuroimaging; neurotransmitters; fmri}, abstract = {Increasing evidence suggests that modulations of the gut-brain axis with probiotics impact healthy ageing. This double-blinded, randomised, placebo-controlled study compared effects of micro-encapsulated and non-encapsulated Lacticaseibacillus rhamnosus HN001 in 87 community-dwelling elderly (60-80 years). Resting state functional connectivity differed significantly in regions involved in visual processing and perception between the two probiotic groups (p < 0.0001). Brain morphometry was not altered. Significant time*group effects (p < 0.05) were observed for processing speed, non-significant effects for short-term memory and anxiety symptoms, while other cognitive domains, depression, perceived stress, and sleep quality were unaffected. Distribution of available and stored peripheral serotonin was significantly affected (p < 0.05), while levels of γ-aminobutyric acid and glutamate in striatum and circulating brain-derived neurotrophic factor did not show significant time*group effects. Micro-encapsulated probiotics target the gut differently, which impacts the effects on brain health assessed by (functional) magnetic resonance imaging in older adults. The trial is registered at ClinicalTrials.gov under ID: NCT05801042.}, issn = {0889-1591} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_buhhalkon_2025, title = {Microplastics (10 µm-5 mm) in European Atlantic Coastal Waters}, author = {Buhhalko, N. and Kuddithamby, G. and Vianello, A. and Rotander, Anna and Vidal-Liñán, L. and Beiras, R. and Falcou-Préfol, M. and Town, R.M. and Hylland, K. and Morin, B. and Cachot, J. and Clérandeau, C. and Blust, R. and Nielsen, T. G. and Lips, U. and Garaventa, F. and Vollertsen, J. and Regoli, F. and Almeda, R.}, year = {2025}, journal = {Environmental Advances}, volume = {21}, doi = {10.1016/j.envadv.2025.100644}, url = {2028238}, language = {eng}, publisher = {Elsevier}, keywords = {analytical methods; atlantic waters; microplastics; pollution hotspots; sampling techniques}, abstract = {Microplastics (MPs) are pervasive pollutants in coastal waters, raising significant ecological concerns. This study assessed the abundance and characteristics of small-sized MPs (down to 10 µm) across European Atlantic coastal sites using harmonized sampling and analytical methods. A filter-pump microplastic sampler, the "Universal Filtering Object" (UFO), was employed at all sites, with Manta net (300-µm mesh) sampling conducted at selected locations. Microplastic concentrations ranged from <10 MPs m-3 to >1600 MPs m-3, with the Gulf of Finland showing the lowest concentration (5 MPs m-3) and the Scheldt estuary in Belgium the highest (1603 MPs m-3). Most MPs (80%) were <300 µm, primarily consisting of polyester, polypropylene, and polyethylene fragments. Manta net sampling consistently underestimated both total microplastic concentrations and microplastics larger than 300 µm compared to UFO sampling. Estuaries and wastewater effluents were identified as pollution hotspots, strongly influencing local MP distributions. The median microplastic concentration found in European Atlantic waters in this study was lower than the global median for coastal waters measured using pump-based sampling devices. Although current MP levels are unlikely to pose an immediate risk to the marine pelagic food web, the projected increase in plastic production, combined with its low degradability and chemical leaching, underscores the urgency of implementing mitigation measures to prevent future environmental impacts. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_suljevidamir_2025, title = {Microplastics and nanoplastics co-exposure modulates chromium bioaccumulation and physiological responses in rats}, author = {Suljević, Damir and Karlsson, Patrik and Fočak, Muhamed and Brulić, Maja Mitrašinović and Sulejmanović, Jasmina and Šehović, Elma and Särndahl, Eva and Engwall, Magnus and Alijagic, Andi}, year = {2025}, journal = {Environment International}, volume = {198}, doi = {10.1016/j.envint.2025.109421}, url = {1949213}, language = {eng}, publisher = {Elsevier}, keywords = {polystyrene particles; heavy metals; mixture toxicity; liver; brain}, abstract = {The environmental fragmentation of plastics generates a mixture of plastic particles of various sizes, which frequently co-occur with other mobile and persistent environmental pollutants. Despite the prevalence of such scenarios, the interaction between micro- and nanoplastics (MNPs) and their combined effects with environmental pollutants, such as highly toxic hexavalent chromium (Cr(VI)), remain almost entirely unexplored in mammalian species. This study demonstrated that nanoplastic and microplastic particles co-aggregate and together influence Cr bioaccumulation patterns and related physiological alterations in rats. Following a four-week repeated intragastric exposure of Wistar rats to MNPs and Cr(VI), either alone or in combination, MNPs significantly enhanced Cr bioaccumulation in the liver, heart, brain, and skin. Under co-exposure conditions, Cr(VI) was the primary driver of cellular effects observed in the blood, including shifts in immune cell subpopulations (e.g., neutrophils, lymphocytes) and alterations in red blood cell indices, while serum biochemistry reflected limited physiological stress. MNPs per se decreased creatine kinase activity and increased cholesterol levels. In summary, polystyrene MNPs increase Cr(VI) distribution and bioavailability, but co-exposure does not uniformly exacerbate toxicity. Instead, their interaction may selectively alter physiological responses, emphasizing the need for a deeper understanding of their combined effects and potential health risks.}, issn = {0160-4120} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_malayaperumalsarubala_2025, title = {MicroRNA-122 overexpression suppresses the colon cancer cell proliferation by downregulating the astrocyte elevated gene-1/metadherin oncoprotein}, author = {Malayaperumal, Sarubala and Sriramulu, Sushmitha and Jothimani, Ganesan and Banerjee, Antara and Zhang, Hong and Mohammed Rafi, Shabana Thabassum and Ramachandran, Ilangovan and Nr, Rajesh Kanna and Sun, Xiao-Feng and Pathak, Surajit}, year = {2025}, journal = {Annals of Medicine}, volume = {57}, number = {1}, doi = {10.1080/07853890.2025.2478311}, url = {1951470}, language = {eng}, publisher = {Taylor & Francis}, keywords = {aeg-1/mtdh; tcga-coad; apoptosis; colon cancer; inflammatory cytokines; mir-122}, abstract = {BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs that regulate essential cellular functions, such as cell adhesion, proliferation, migration, invasion, and programmed cell death, and therefore, alterations in miRNAs can contribute to carcinogenesis. Previous studies have shown that miRNA-122 is abundant in the liver and regulates cell proliferation, migration, and apoptosis. However, the expression pattern and mechanism of actions of miR-122 remain primarily unknown in colon cancer.METHODS: In this study, we analyzed The Cancer Genome Atlas Colon Adenocarcinoma (TCGA-COAD) database to assess the clinical significance of astrocyte elevated gene-1 (AEG-1)/metadherin (MTDH) and miR-122 in colon cancer. MiR-122 overexpression studies were performed in HCT116, SW480, and SW620 cell lines. Dual-luciferase assay was carried out to confirm the interaction between AEG-1 and miR-122. In vivo-JetPEI-transfection reagent was used for in-vivo transient transfection of miR-122 in the AOM/DSS-induced colon tumor mouse model.RESULTS: Our results demonstrate that miR-122 was downregulated in colon cancer cells, and it influences the expressions of apoptotic factors and inflammatory cytokines. MiR-122 overexpression in HCT116, SW480, and SW620 cells showed upregulation of Caspase 3, Caspase 9, and BAX and decreased expression of BCL2, which are pro-apoptotic and anti-apoptotic members that maintain a ratio between cellular survival and cell death. In vivo transient transfection of miR-122 mimic in AOM/DSS induced colon tumor mouse model showed less inflammation and disease activity. The TCGA-COAD data indicated that AEG-1 expression was higher in patients with low expression of miR-122 and lower AEG-1 expression in patients with higher expression miR-122.CONCLUSION: Our findings highlight the key role of miR-122 in the high grade of colonic inflammation, and possibly in colon cancer, and the use of miR-122 mimic might be a therapeutic option.}, issn = {0785-3890} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_forssanders_2025, title = {Microscopic colitis and risk of venous thromboembolism : A nationwide matched cohort study}, author = {Forss, Anders and Bröms, Gabriella and Bergman, David and Thuresson, Marcus and Sun, Jiangwei and Eriksson, Carl and Olén, Ola and Zöller, Bengt and Ludvigsson, Jonas F.}, year = {2025}, journal = {American Journal of Gastroenterology}, volume = {120}, number = {12}, pages = {2867--2876}, doi = {10.14309/ajg.0000000000003408}, url = {1944546}, language = {eng}, publisher = {Blackwell Publishing}, keywords = {biopsy; inflammatory bowel disease; microscopic colitis; venous thromboembolism}, abstract = {INTRODUCTION: Inflammatory diseases have been associated with increased risk of venous thromboembolism (VTE). However, data on VTE are lacking in large population-based cohorts of microscopic colitis (MC).METHODS: This study included all Swedish adults with incident MC without prior VTE (1990-2017; n = 12,489; follow-up until 2021). MC and subtypes (collagenous colitis and lymphocytic colitis) were defined from prospectively recorded colorectal histopathology reports from all 28 pathology departments in Sweden. Individuals with MC were matched for birth year, sex, calendar year, and county with up to 5 general population reference individuals (n = 55,809) without prior MC. Sensitivity analyses included full sibling comparisons and stricter definitions of VTE requiring a primary diagnosis of VTE and a prescription of anticoagulant medication. Incidence rates and multivariable-adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for VTE events were calculated using Cox proportional hazards modelling.RESULTS: Over a median of 10.0 years of follow-up, 755 (6.0%; 11.3/1,000 person-years) incident VTE events occurred in individuals with MC and 2,674 (4.8%; 8.6/1,000 person-years) in reference individuals. Individuals with MC had a higher overall relative risk of any VTE event compared with reference individuals (aHR 1.21, 95% CI 1.11-1.32) including higher risk of pulmonary embolism (aHR 1.23, 95% CI 1.08-1.40), deep vein thrombosis of the legs (aHR 1.16, 95% CI 1.03-1.32), and other VTE events (aHR 1.31, 95% CI 1.08-1.58). The results remained robust in sensitivity analyses.DISCUSSION: In this population-based study, individuals with MC had a 21% higher risk of VTE compared with reference individuals, equivalent to 1 extra VTE event for every 37 MC individuals followed for 10 years.}, issn = {0002-9270} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_novakazifjoll_2025, title = {Mind Over Matter - Investigating the Influence of Driver's Perception in the Misuse of Automated Vehicles}, author = {Novakazi, Fjollë and Kim, Soyeon and Karlsson, MariAnne}, year = {2025}, pages = {117--128}, doi = {10.1145/3744333.3747835}, url = {2039456}, language = {eng}, publisher = {Association for Computing Machinery (ACM)}, keywords = {driving automation; automated vehicle; perception; mental model; use error; misuse}, abstract = {As vehicles with several levels of automation become increasingly common, there is an increase in incidents involving the misuse of Driving Automation Systems (DAS). The manner in which drivers interact with DAS indicates that the problem extends beyond UI design. We investigate how drivers' perceptions and expectations affect the understanding and consequent usage of DAS. The study employed a Wizard-of-Oz approach to simulate a vehicle with a Level 2 and Level 3 DAS on a public highway. Sixteen participants were exposed to the two driving modes and two distinct UIs. Observations, think-aloud protocols, and in-depth interviews documented their interaction with the different DAS. Irrespective of the UI, various errors were detected, including omission, commission, and mode confusion. Deeper investigation into the sources led to the conclusion that drivers' preconceptions of the DAS were a major contributor, resulting in misuse. This highlights the need to look beyond UI design as a sole solution to address driver-vehicle interaction.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zhangguodong_2025, title = {Mindfulness, mind-body exercises, and health promotion}, author = {Zhang, Guodong and Cao, Yang and Yan, Zi}, year = {2025}, journal = {Frontiers in Psychology}, volume = {16}, doi = {10.3389/fpsyg.2025.1559535}, url = {1938913}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {daoism; health promotion (hp); mind-body exercise; mindfulness; restoration; stillness} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ekmanbertil_2025, title = {Mineralocorticoid effects of fludrocortisone and hydrocortisone in primary adrenal insufficiency : EU-AIR patient data}, author = {Ekman, Bertil and Quinkler, Marcus and Zhang, Pinggao and Isidori, Andrea M. and Murray, Robert D. and Wahlberg, Jeanette}, year = {2025}, journal = {Journal of Endocrinological Investigation}, volume = {48}, number = {10}, pages = {2381--2392}, doi = {10.1007/s40618-025-02657-7}, url = {1995796}, language = {eng}, publisher = {Editrice Kurtis}, keywords = {fludrocortisone; glucocorticoid; hydrocortisone; mineralocorticoid; primary adrenal insufficiency}, abstract = {PURPOSE: Patients with primary adrenal insufficiency (PAI) require mineralocorticoid replacement therapy in addition to glucocorticoids. These therapies should be considered in combination because most glucocorticoids also possess mineralocorticoid activity. We aimed to investigate the relationship between fludrocortisone and hydrocortisone-equivalent dosing in patients with PAI.METHODS: Data were obtained from the European Adrenal Insufficiency Registry (EU-AIR), a multinational, multicenter, observational study conducted between August 7, 2012, and October 31, 2020, in endocrinology centers in Germany, Italy, the Netherlands, Sweden, and the UK. Patients with PAI (excluding congenital adrenal hyperplasia or known hypertension) and treated with immediate-release hydrocortisone (IRHC), modified-release hydrocortisone (MRHC), or cortisone acetate were included. The relationship between hydrocortisone-equivalent and fludrocortisone doses and mineralocorticoid potency corrected for body surface area (BSA) was examined.RESULTS: Overall, 670 (mean age: 46.2 years; 453 [67.6%] women) of 924 patients with PAI in EU-AIR were analyzed. Of those who received at least one dose of fludrocortisone (n = 350), 45 patients (12.9%) were receiving hydrocortisone-equivalent doses/BSA of ≤ 10 mg/day/m2, 170 patients (48.6%) > 10-15 mg/day/m2, and 133 patients (38.0%) > 15 mg/day/m2. No clear associations were found between total daily fludrocortisone dose/BSA and hydrocortisone-equivalent dose/BSA, or between combined mineralocorticoid potency/BSA and systolic or diastolic blood pressure and sodium or potassium levels. Higher systolic blood pressure was found in IRHC than MRHC groups.CONCLUSIONS: Fludrocortisone prescription in PAI appears to be independent of glucocorticoid replacement therapy. IRHC and MRHC might differ in mineralocorticoid effect owing to different pharmacokinetic profiles.CLINICAL TRIAL REGISTRATION: NCT01661387.}, issn = {0391-4097} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_katawazaiasmatullah_2025_3, title = {Minimal Incision Repair of Rectus Abdominis Diastasis (MIRRAD) as day-case surgery : A prospective study}, author = {Katawazai, Asmatullah and Wallin, Göran and Sandblom, Gabriel}, year = {2025}, journal = {Hernia}, volume = {29}, number = {1}, doi = {10.1007/s10029-025-03306-x}, url = {1952590}, language = {eng}, publisher = {Springer}, keywords = {linea alba; minimal incision surgery; postpartum rectus diastasis; rectus diastasis; ventral hernia}, abstract = {PURPOSE: Postpartum rectus abdominis diastasis (PP-RAD) is a condition that may cause abdominal wall insufficiency, affecting daily life. When conservative treatments are unsuccessful, surgical intervention may be necessary. This study aimed to assess the safety and effectiveness of minimal incision repair of rectus abdominis diastasis (MIRRAD) as day-case surgery in women with PP-RAD.METHODS: This study included 33 female patients aged 20-50 years with PP-RAD and an inter-rectus distance (IRD) of ≥ 3 cm. All patients had previously undergone conservative treatment without satisfactory outcomes. Each patient received the MIRRAD procedure as day-case surgery apart from one who stayed overnight due to nausea. Follow-up evaluations were conducted at 4 h, 1 week, 1 month, and 1 year after surgery.RESULTS: The average inter-rectus distance (IRD) was 4.4 cm, with a mean diastasis length of 15 cm. Of the 33 patients included, 2 did not attend the 1 year follow-up leaving 31 for final analysis. Of these, 30 had one or more concomitant hernias. The mean operation time was 67 min. At the 1 year follow-up, 87% of patients were satisfied with the results, and 90% said they would undergo the procedure again if necessary. No surgical site infection was reported, and recovery was generally smooth. Thirty of the 31 patients were discharged within 4 to 6 h after surgery, while one patient stayed overnight.CONCLUSION: MIRRAD appears to be a safe and effective surgical option for PP-RAD, particularly in cases without significant excess skin. Further studies with larger populations and longer follow-up are needed to confirm these findings and establish standard patient selection criteria.}, issn = {1265-4906} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_aggererik_2025, title = {Minimally invasive approach to resection surgery in right sided malignant obstruction improved short-term outcomes - a population-based cohort study}, author = {Agger, Erik and Matthiessen, Peter and Vedin, Tomas}, year = {2025}, journal = {British Journal of Surgery}, volume = {112}, number = {Suppl. 11}, pages = {xi20--xi20}, doi = {10.1093/bjs/znaf149.070}, url = {1992660}, language = {eng}, publisher = {Oxford University Press}, abstract = {Introduction: Minimally invasive surgery (MIS) improves short-term outcomes in elective colectomy, however, its current utilization in an emergency setting is limited. Malignant obstruction is the most common indication for emergency right sided colectomy. The current study aims to assess short-term outcomes of MIS in these patients.Method: Patients undergoing emergency right sided colectomy in Sweden between 2017 and 2023 were identified through the Swedish ColoRectal Cancer Registry. Outcome measures included length of stay (LOS), complication rate and surgical quality indicators, and were analyzed on intention to treat.Result: In total 1147 patients fulfilled inclusion criteria. Open resection (OPEN) was completed in 94.3%(n=1082) and MIS resection in 5.7%(n=65) of patients. The conversion rate was 34% (n=34/99). Age, sex, BMI, ASA and tumour characteristics were similar between groups.LOS was shorter after MIS, 6 (IQR 4-8) compared to 8 (IQR 6-13) days in OPEN. Univariable and multivariable survival analysis showed significant advantage for MIS; HR 0.64 (95% CI 0.49-0.83, p<0.001); HR 0.67 (95% CI 0.51-0.87, p=0.002), respectively.Post-operative complication rate after OPEN and MIS were 35.3% and 21.5%, respectively (p=0.026). In regression analysis of factors affecting postoperative complications; ASA-classification, male gender, and permanent ostomy had a statistically significant effect on this outcome. MIS had no significant impact on overall complications in step-wise regression analysis; OR 0.57 (95% CI 0.31-1.05, p=0.07).Non-inferiority analysis of surgical quality indicators did not show inferiority of the MIS approach.Discussion: Emergency MIS might offer short-term benefits in patients with malignant right sided obstruction.}, issn = {0007-1323} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_smaniottovittorino_2025, title = {MiniMed 780G system performance in older users with type 1 diabetes : Real-world evidence and the case for stricter glycaemic targets}, author = {Smaniotto, Vittorino and Heller, Simon and O'Neal, David and Jendle, Johan and Cukierman-Yaffe, Tali and Arrieta, Arcelia and Thijs, Isabeau and Castañeda, Javier and van den Heuvel, Tim and Cohen, Ohad}, year = {2025}, journal = {Diabetes, obesity and metabolism}, volume = {27}, number = {4}, pages = {2242--2250}, doi = {10.1111/dom.16227}, url = {1935307}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {continuous glucose monitoring (cgm); database research; insulin pump therapy; real‐world evidence; type 1 diabetes}, abstract = {AIMS: Large-scale studies on the effectiveness of automated insulin delivery (AID) systems in older people with type 1 diabetes are still limited. A multinational, retrospective, real-world study was conducted to examine the performance of the MiniMed™ 780G advanced hybrid closed-loop system in users with type 1 diabetes aged ≥56 years compared with those aged 16-55 years.MATERIALS AND METHODS: Data from 35 366 MiniMed™ 780G system users aged 16-55 years and 7415 users aged ≥56 years were included. The main outcome was time in range 70-180 mg/dL (TIR); other continuous glucose monitoring (CGM) metrics were also assessed.RESULTS: Across all users, mean TIR was 77.1% for users aged ≥56 years and 73.1% for those aged 16-55 years (Δ4.0, 95% confidence interval [CI]: 3.8-4.2, p <0.0001). In users employing the optimal system settings (i.e., Glucose Target: 100 mg/dL; active insulin time: 2 h), mean TIR was 81.9% in older and 79.7% in younger users (Δ2.2, 95% CI: 1.5-2.9, p <0.0001). Across all users, mean time below range <70 mg/dL (TBR70) was 1.5% in older and 2.1% in younger users. In older users, TIR and TBR70 remained consistent over 12 months.CONCLUSIONS: This real-world analysis demonstrated that older MiniMed™ 780G system users with type 1 diabetes can achieve a TIR >70% without increasing hypoglycaemia risk. Users employing optimal settings showed the best outcomes. The system performed as well as or better than in younger users. These findings support the case that more stringent TIR targets can be achieved safely.}, issn = {1462-8902} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gullikssonmrten_2025, title = {Minimum VaR and minimum CVaR optimal portfolios : The case of singular covariance matrix}, author = {Gulliksson, Mårten and Mazur, Stepan and Oleynik, Anna}, year = {2025}, journal = {Results in Applied Mathematics}, volume = {26}, doi = {10.1016/j.rinam.2025.100557}, url = {1943326}, language = {eng}, publisher = {Elsevier}, keywords = {minimum var portfolio; minimum cvar portfolio; singular covariance matrix; linear ill-posed problems}, abstract = {This paper examines optimal portfolio selection using quantile-based risk measures such as Value-at-Risk (VaR) and Conditional Value-at-Risk (CVaR). We address the case of a singular covariance matrix of asset returns, which may arise due to potential multicollinearity and strong correlations. This leads to an optimization problem with infinitely many solutions. An analytical form for a general solution is derived, along with a unique solution that minimizes the -norm. We show that the general solution reduces to the standard optimal portfolio for VaR and CVaR when the covariance matrix is non-singular. We also provide a brief discussion of the efficient frontier in this context. Finally, we present a real-data example based on the weekly log returns of assets included in the S&P 500 index.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wistrandsten_2025_2, title = {Minnesvärd bifigur i litteraturens lägre liga}, author = {Wistrand, Sten}, year = {2025}, journal = {Svenska Dagbladet}, number = {12 juni}, pages = {37--37}, url = {1971842}, language = {swe}, publisher = {Hb Svenska dagbladets AB & Co}, keywords = {greve stanislaus eric stenbock}, issn = {1101-2412} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindskldmarcus_2025, title = {Minor impact of anastomotic leakage on long-term quality of life after anterior resection : a population-based cohort study}, author = {Lindsköld, Marcus and Gerdin, Anders and Park, Jennifer and Haggström, Jenny and Lydrup, Marie-Louise and Matthiessen, Peter and Jutesten, Henrik and Sandberg, Sofia and Angenete, Eva and Vinnars, Petrus and Buchwald, Pamela and Rutegård, Martin}, year = {2025}, journal = {British Journal of Surgery}, volume = {112}, number = {Suppl. 11}, pages = {xi16--xi16}, doi = {10.1093/bjs/znaf149.057}, url = {1992009}, language = {eng}, publisher = {Oxford University Press}, abstract = {Introduction: Anastomotic leakage (AL) following anterior resection (AR) for rectal cancer impacts morbidity and bowel dysfunction. The aim of this study was to evaluate the impact of leakage on health-related quality of life (HRQoL) three years after surgery, as the evidence regarding long-term effects is limited.Method: This population-based observational study included patients who underwent AR in Sweden between 2015 and 2017, retrieved from the Swedish Colorectal Cancer Registry. The main outcome measure was the summary score of EORTC QLQ–C30, a validated questionnaire developed to assess the quality of life of cancer patients, three years after surgery; secondary outcomes were from the colorectal-cancer specific EORTC QLQ–CR29. Targeted maximum likelihood estimation was used to assess the influence of leakage on HRQoL, accounting for confounders.Result: Of 1,778 eligible patients, 1,178 (66.3%) responded, including 104 (8.8%) with AL. Patients with leakage reported a significantly lower summary score, considered a small difference (80 vs. 86, p < 0.001); this effect was estimated at -4 (p = 0.002) after adjustment. These patients also had worse body image, more sore skin around the anus and more leakage of stool from the stoma bag (if present), considered medium differences.Discussion: AL following AR seems to have a minor negative impact on HRQoL three years postoperatively, while these patients have a worse reported body image, sore skin around the anus and leakage of stool from the stoma bag. These findings highlight the importance of patient counselling and long-term follow-up for patients with AL.}, issn = {0007-1323} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wurmmatilda_2025, title = {Minority Stress, General Stress, and Family Support : Associations With Mental Health and Quality of Life in LGBTQ+ Young Adults During the Covid-19 Pandemic}, author = {Wurm, Matilda and Bergbom, Sofia and Di Luigi, Guendalina and Della Casa, Veronica and Malmquist, Anna}, year = {2025}, journal = {Scandinavian Journal of Psychology}, volume = {66}, number = {6}, pages = {815--825}, doi = {10.1111/sjop.13122}, url = {1957652}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {internalized homophobia; internalized transphobia; psychological health; sexual and gender minority; transgender and nonbinary; youth}, abstract = {By simultaneously examining minority-related stressors and general stressors experienced by the whole population, the study's aim was to provide a more comprehensive understanding of the health and well-being of LGBTQ+ young adults in Sweden during the Covid-19 pandemic. This study explored differences in mental health and quality of life between subgroups of young LGBTQ+ adults. Further, it explored how distal and proximal minority stressors, as well as stress related to the Covid-19 pandemic, and family support were associated with mental health outcomes (depression, anxiety, and quality of life) using linear regression analyses in a sample of 245 young LGBTQ+ Swedish individuals. The results showed increased mental distress in transgender and nonbinary (TNB) young adults and that minority stress influences health in LGBTQ+ young adults above and beyond the general stress of living through a pandemic. Nevertheless, different predictors were significant for different outcomes. For all outcomes, family support was highlighted as an important protective factor for LGBTQ+ young adults. Findings support the minority stress model and highlight the need for interventions aimed at reducing minority stress as well as tailored support and resources for TNB individuals during times of general high stressor load. This may include support aimed at their close families.}, issn = {0036-5564} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonjoakim_2025, title = {Misrepresenting Muslims? Critical Perspectives on Migration Policy Change in Sweden 2015-2023}, author = {Johansson, Joakim and Elander, Ingemar}, year = {2025}, journal = {Siyasal: Journal of Political Sciences}, volume = {34}, number = {1}, pages = {1--15}, doi = {10.26650/siyasal.2025.34.1441240}, url = {1953677}, language = {eng}, publisher = {İstanbul Üniversitesi Siyasal Bilgiler Fakültesi}, keywords = {migration; muslims; security; intersectionality; gender}, abstract = {Drawing upon an analytical combination of critical security studies (CST) and intersectional theory (IT), we in this article focus on migration policy in Sweden 2015-2023 with a particular focus on representations of Islam and Muslims. Using thematic analysis, arguments, and statements raised by key political actors, i.e., the Swedish Government and the radical-right/retrotopian party Sweden Democrats, we study the threats as perceived to legitimize the Swedish Government’s turn to a more restrictive stance. Exploring the official, justifying points of this policy turn, we also exemplify our approach by referencing policy repercussions related to the Russian attack on Ukraine. Outstanding findings in the material include continuous attempts to de-masculinize Muslim men who are constructed interchangeably as welfare recipients, violent and eager terrorists, exponents of criminal behavior in general, or failing in their role as protectors of women and children. All in all, these findings are representations of a particular ‘Swedish’ culture, the welfare state and individual responsibility implicating a mission to save a national ‘We’ from a foreign ‘Them’ built around negative stereotypes of Muslims. In addition to illustrating the analytical strength of securitization theory, we also demonstrate the complementary capacity of intersectional theory for an analysis of migration policy change.}, issn = {2618-6330} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_joelssontanja_2025_1, title = {Mobile caringscapes : Walking as an infrastructure of care in disadvantaged neighbourhoods in Sweden}, author = {Joelsson, Tanja and Balkmar, Dag and Henriksson, Malin}, year = {2025}, journal = {Mobilities}, volume = {20}, number = {1}, pages = {1--17}, doi = {10.1080/17450101.2024.2371598}, url = {1886106}, language = {eng}, publisher = {Routledge}, keywords = {walking; families; caringscapes; infrastructures of care; disadvantaged neighbourhoods; sweden}, abstract = {The welfare state planning of the Nordic countries can be said to have been carried out as political acts of state care and concern of (some of) their citizens, to tackle poverty and poor housing conditions, and provide more equal living conditions for the whole population. The Million Programme Housing Project (MP) was an ambitious project carried out to combat housing shortage in Sweden in the 1960s and 1970s, which also resulted in traffic separation, car-free courtyards and housing blocks, and recreational green infrastructure. By analysing accounts of walking in 47 interviews around the everyday mobilities of 31 families living in three disadvantaged MP areas in three cities in Sweden, we suggest that the walking practices can be regarded as 'caringscapes'. The narratives of the participants illuminate how walking is both self-care, other-care, and neighbourhood-care. Taken together, these different facets of 'caringscapes' of walking are further discussed in relation to walking as an enacted and practiced infrastructure of care. This conceptual framework of care captures the different experiential facets of walking and highlights the embodied, interdependent, and relational aspects of walking.}, issn = {1745-0101} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sundqvistnicolas_2025, title = {Model-driven meta-analysis establishes a new consensus view : Inhibitory neurons dominate BOLD-fMRI responses}, author = {Sundqvist, Nicolas and Podéus, Henrik and Sten, Sebastian and Engström, Maria and Dura-Bernal, Salvador and Cedersund, Gunnar}, year = {2025}, journal = {Computers in Biology and Medicine}, volume = {197}, number = {Pt A}, doi = {10.1016/j.compbiomed.2025.111014}, url = {1997369}, language = {eng}, publisher = {Elsevier}, keywords = {bold; inhibitory neurons; mathematical modelling; nvc; ois; fmri}, abstract = {Functional magnetic resonance imaging (fMRI) is a pivotal tool for mapping neuronal activity in the brain. Traditionally, the observed hemodynamic changes are assumed to reflect the activity of the most common neuronal type: excitatory neurons. In contrast, recent experiments, using optogenetic techniques, suggest that the fMRI-signal could reflect the activity of inhibitory interneurons. However, these data paint a complex picture, with numerous regulatory interactions, and with responses that sometimes seem to point in different directions. It is therefore not trivial how to quantify the relative contributions of the different cell types into a consensus view compatible with the considered data. To address this, we present a new model-driven meta-analysis, which provides a unified and quantitative explanation for the considered data. This model-driven analysis allows for quantification of the relative contribution of different cell types: the contribution to the BOLD-signal from the excitatory cells is <20 % and 50-80 % comes from the interneurons. Our analysis also provides a mechanistic explanation for the observed experiment-to-experiment differences. For instance, one of the reasons that data seem to point in different directions is a biphasic vascular response, with a transient increase and a subsequent decrease. Our model-based data analysis explains why this biphasic response appears only for high-intensity stimulations and not for low-intensity stimulations. In other words, our meta-analysis goes beyond a simple vote-by-majority and provides a single unified explanation for the considered data. This explanation provides a consensus view that constitutes a paradigm shift in how fMRI can, and cannot, be used to interpret neuronal activity.}, issn = {0010-4825} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fridljungjasmine_2025, title = {Modelling the cost-effectiveness of cervical cancer screening with HPV self-sampling and molecular triage for women aged 60-69 years}, author = {Fridljung, Jasmine and Bergengren, Lovisa and Ryen, Linda and Lillsunde-Larsson, Gabriella}, year = {2025}, journal = {Discover Oncology}, volume = {16}, number = {1}, doi = {10.1007/s12672-025-02432-3}, url = {1959103}, language = {eng}, publisher = {Springer}, keywords = {cervical screening; cost-effectiveness; economic evaluation; genotyping; hpv; hsil; methylation; self-sampling}, abstract = {BACKGROUND: Since 2022, self-sampling has been recommended in Sweden's cervical screening program. Despite still being used primarily for long-term non-attendees, its expected increase in use raises interest in molecular triage methods applicable to self-collected samples. Postmenopausal women face screening challenges due to physiological changes, making this group particularly relevant for evaluating alternative strategies. This study models the cost-effectiveness of different sampling and triage methods in identifying histological high-grade squamous intraepithelial lesions (HSIL) in women aged 60-69 years.METHODS: Using real-world data, this study compares the cost-effectiveness of currently implemented strategy based on professional HPV sampling and combination triage with genotyping and cytology, with modelled strategies based on self-sampling and various molecular triage. The comparison evaluates healthcare resource use and the number of identified histological HSIL cases. The analysis focuses on a single screening cycle, re-testing of invalid samples or screening-positive/triage-negative women are not addressed.RESULTS: Screening with molecular triage either leads to decreases in effect, i.e. fewer histological HSIL identified, or significant cost increases due to higher rate of HPV-positive screening samples and higher number of colposcopy follow-ups.CONCLUSIONS: Molecular triage, whether used with self-sampling or professional sampling, does not appear cost-effective for identifying HSIL in this age group compared to the current screening strategy.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jassjana_2025, title = {Models and challenges for studying forever chemicals and their impact on human health}, author = {Jass, Jana and Bezabhe, Yared and Mustafa, Majid and Ragnvaldsson, Daniel and Olsson, Per-Erik}, year = {2025}, journal = {Disease Models and Mechanisms}, volume = {18}, number = {11}, doi = {10.1242/dmm.052320}, url = {2007408}, language = {eng}, publisher = {The Company of Biologists Ltd.}, keywords = {effects; mechanism of action; model systems; pfas}, abstract = {Per- and polyfluoroalkyl substances (PFAS), also known as 'forever chemicals', are of high concern for human and ecosystem health. PFAS were first synthesised and developed in the late 1930s, and are now commonplace in many everyday objects, such as frying pans, food packaging and cleaning products. Due to their long half-life, these chemicals remain at high concentrations in both the environment and within exposed organisms, where they have toxic effects. Several model and animal models have been developed to help determine the deleterious effects of PFAS, which has led to the identification of multiple pathways and mechanisms that are affected or presumed to be affected. In this Review, we present an overview of PFAS and discuss possible effects on humans and wildlife. We discuss the pros and cons of various vertebrate and invertebrate model systems that have been used to study PFAS. Finally, to further address these chemicals in the future, we discuss different approaches to removing PFAS from the environment.}, issn = {1754-8403} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ljunggrenmirjam_2025, title = {Moderate to Severe Obstructive Sleep Apnea Is a Risk Factor for Severe COVID-19 : A Nationwide Cohort Study}, author = {Ljunggren, Mirjam and Palm, Andreas and Ekström, Magnus and Sundh, Josefin and Grote, Ludger and Li, Huiqi and Nyberg, Fredrik and Emilsson, Össur Ingi}, year = {2025}, journal = {Journal of Sleep Research}, doi = {10.1111/jsr.70082}, url = {1956506}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {cpap; sars‐cov2; oxygen desaturation index; sleep disordered breathing}, abstract = {The impact of obstructive sleep apnea (OSA) and positive airway pressure (PAP) treatment on COVID-19 severity is unclear. In this population-based, nationwide study using multi-register data, we aimed to assess if OSA is a risk factor for COVID-19 severity and how adherence to PAP treatment and clinical characteristics affect the risk. Swedish residents with COVID-19 infection January 2020-May 2022 were included. An exposed group of OSA (starting PAP treatment 2015-2019) was identified. COVID-19 severity outcome was defined as mild (non-hospitalised), severe (hospitalised) or critical (intensive care or death). Covariates included comorbidities and sociodemographics. Conditional odds ratios (COR) with 95% confidence intervals (95% CI) were estimated using multinomial logistic regression. Among 8,894,162 individuals in Sweden, 1,932,081 (21.7%) had registered COVID-19 January 2020-May 2022. OSA was identified in 11,407 (0.6%) and was associated with an increased risk of severe (COR 1.34; 95% CI 1.25-1.43) and critical (1.25; 1.11-1.42) COVID-19 after adjustment for age, sex, education and comorbidities. Stratified by PAP adherence, age and COVID-19 wave, OSA was a risk factor for more severe COVID-19 in PAP-adherent and non-adherent individuals, in people aged 40-60 but not > 60 years and not after June 2021. OSA severity, assessed with the oxygen desaturation index (ODI), was independently associated with COVID-19 severity, with the highest risks for severe (1.23; 1.01-1.52) and critical (1.76; 1.17-2.63) COVID-19 observed in ODI ≥ 30 (vs. ODI < 15). We conclude that patients with moderate to severe OSA have an increased risk of severe COVID-19, also when PAP-treated, with an independent dose-response relationship between the severity of intermittent hypoxia and COVID-19 severity.}, issn = {0962-1105} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ljunggrenmirjamelisa_2025, title = {Moderate to severe obstructive sleep apnea is a risk factor for severe COVID-19-a nationwide cohort study}, author = {Ljunggren, Mirjam Elisa and Palm, Andreas and Ekström, Magnus and Sundh, Josefin and Grote, Ludger and Li, Huiqi and Nyberg, Fredrik and Emilsson, Össur Ingi}, year = {2025}, journal = {European Respiratory Journal}, volume = {66}, number = {Suppl. 69}, doi = {10.1183/13993003.congress-2025.PA1366}, url = {2040387}, language = {eng}, publisher = {European Respiratory Society}, abstract = {Aim: To assess if obstructive sleep apnea (OSA) is a risk factor for COVID-19 severity, and how adherence to positive airway pressure (PAP)-treatment and clinical characteristics affect the risk.Methods: A nationwide study using multi-register data. Among all Swedish residents aged ≥18 years, individuals with COVID-19 infection January 2020-May 2022 were included. An exposed group of OSA (starting PAP-treatment 2015-2019) was identified. COVID-19 severity outcome was defined as mild (non-hospitalised), severe (hospitalised), or critical (admitted to intensive care or death). Conditional odds ratios (COR) with 95% confidence intervals (95%CI) were estimated using multinomial logistic regression.Results: Among 8,894,162 Swedish residents, 1,932,081 (21.7%) had a registered COVID-19 January 2020-May 2022. OSA was identified in 11,407 (0.6%), and was associated with an increased risk of severe (COR 1.34; 95%CI 1.25-1.43) and critical (1.25; 1.11-1.42) COVID-19 after adjustment for age, sex, education and comorbidities. When stratified by PAP-adherence, age, and COVID-19 wave, OSA was a risk factor for severe and critical COVID-19 in adherent and non-adherent individuals, in people aged 40-60 but not >60 years and not after June 2021. OSA-severity, assessed with oxygen desaturation index (ODI), was independently associated with COVID-19 severity, with the highest risks for severe (1.23; 1.01-1.52) and critical (1.76; 1.17-2.63) COVID-19 observed in those with ODI>30 (vs ODI<15).Conclusions: In the Swedish population, COVID-19 was more often severe or critical in people with OSA, with a dose-response relationship between the severity of intermittent hypoxia and COVID-19 severity.}, issn = {0903-1936} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ljungqvistolle_2025_1, title = {Modern optimal perioperative care in colorectal surgery}, author = {Ljungqvist, Olle}, year = {2025}, journal = {Surgery}, volume = {184}, pages = {109469--109469}, doi = {10.1016/j.surg.2025.109469}, url = {1989933}, language = {eng}, publisher = {Elsevier}, issn = {0039-6060} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lillsundelarssongabriella_2025, title = {Molecular triage on HPV-positive samples in a cervical screening setting}, author = {Lillsunde-Larsson, Gabriella and Carlsson, Jessica and Helenius, Gisela and Bergengren, Lovisa}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {10}, doi = {10.1371/journal.pone.0333539}, url = {2006256}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {OBJECTIVE: To improve human papilloma virus (HPV) screening, more effective triage methods for HPV-positive samples need development and validation. Cytology, the most common triage method today, is subjective and can only be applied to professionally collected samples. Methylation status has been shown to be informative, as genes are highly methylated in HPV-induced cervical dysplasia and cancer. This study aimed to assess whether triaging HPV-positive samples using molecular methods, such as methylation and genotyping for high-risk HPV types, could be as effective as cytology in cervical screening.METHODS: A retrospective biobank study was conducted on HPV-positive samples collected in 2017-2018, analyzing FAM19A4/MiR-124-2 hypermethylation and HPV genotyping for types 16, 18, 31, 33, 45, 52, and/or 59, comparing these results to cytology triage for detecting histologically confirmed high-grade squamous intraepithelial lesions (HSIL) and cancer.RESULTS: Results from 1915 positive screening samples were analyzed, including 1052 follow-up biopsies with 402 HSIL or cancer cases. Genotyping showed slightly higher sensitivity than cytology but lower specificity, while methylation had higher specificity but much lower sensitivity. Cytology's positive predictive value (PPV) was 36%, with lower PPVs for the molecular methods. Combining molecular methods increased the PPV but significantly reduced sensitivity.CONCLUSIONS: Based on these findings with molecular methods reducing sensitivity, we do not recommend adopting the molecular triage methods evaluated in this study in the Swedish setting. The trade-off between sensitivity and specificity does not support a change from the current cytology-based triage approach.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_toulielenafarahbakhsh_2025, title = {Monitoring the Dynamic Networks of Stock Returns with an Application to the Swedish Stock Market}, author = {Touli, Elena Farahbakhsh and Nguyen, Hoang and Bodnar, Olha}, year = {2025}, journal = {Computational Economics}, volume = {65}, number = {3}, pages = {1741--1758}, doi = {10.1007/s10614-024-10616-2}, url = {1858618}, language = {eng}, publisher = {Springer}, keywords = {dynamic network; hierarchical clustering tree; stock returns; tree distance; swedish capital market}, abstract = {In this paper, two approaches for measuring the distance between stock returns and the network connectedness are presented that are based on the Pearson correlation coefficient dissimilarity and the generalized variance decomposition dissimilarity. Using these two procedures, the center of the network is determined. Also, hierarchical clustering methods are used to divide the dense networks into sparse trees, which provide us with information about how the companies of a financial market are related to each other. We implement the derived theoretical results to study the dynamic connectedness between the companies in the Swedish capital market by considering 28 companies included in the determination of the market index OMX30. The network structure of the market is constructed using different methods to determine the distance between the companies. We use hierarchical clustering methods to find the relation among the companies in each window. Next, we obtain a one-dimensional time series of the distances between the clustering trees that reflect the changes in the relationship between the companies in the market over time. The method from statistical process control, namely the Shewhart control chart, is applied to those time series to detect abnormal changes in the financial market.}, issn = {0927-7099} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_ervolaura_2025_2, title = {Moral and Economic Costs of Enforcement}, author = {Ervo, Laura}, year = {2025}, pages = {449--465}, url = {2003799}, language = {eng}, publisher = {Wolters Kluwer} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ervolaura_2025_3, title = {Moral and Economic Costs of Enforcement}, author = {Ervo, Laura}, year = {2025}, journal = {Law & Criminology Journal}, volume = {2}, number = {2}, pages = {45--57}, doi = {10.21825/lcj.94102}, url = {2003798}, language = {eng}, publisher = {Ghent University, Faculty of Law and Criminology}, keywords = {over-indebtedness; rehabilitative enforcement; finnish enforcement system; perceived fairness; voluntary compliance; fraudulent debtors; psychology of enforcement}, abstract = {This article examines the Finnish enforcement system, focusing on the interplay between rehabilitative and social objectives, and the necessity of stringent measures to combat fraudulent debtors. It explores the challenges of designing enforcement policies that simultaneously protect honest, over-indebted individuals while effectively addressing artificial arrangements intended to evade financial obligations. Through an analysis of the psychological dimensions of enforcement, the study underscores the critical role of perceived fairness in fostering voluntary compliance and sustaining trust in the system. The findings suggest that a rehabilitative approach not only benefits debtors by facilitating financial recovery, but also serves the long-term interests of creditors by promoting higher repayment rates and economic stability. Ultimately, the study argues that rather than being inherently contradictory, rehabilitative and punitive measures can be strategically integrated to enhance the overall efficiency and legitimacy of enforcement legislation.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_heidenreichkaja_2025, title = {Moral reasoning during vascular surgeons' case conferences : finding the balance of risk and benefit by exploring the clinical details}, author = {Heidenreich, Kaja and Karlsson, Marit and Bremer, Anders and Svantesson, Mia}, year = {2025}, journal = {HEC Forum}, doi = {10.1007/s10730-025-09550-z}, url = {1977436}, language = {eng}, publisher = {Springer}, keywords = {physicians; qualitative research; vascular surgical procedures}, issn = {0956-2737} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ekestubbelovisa_2025, title = {Morbidity prediction in conservatively managed rib fracture patients}, author = {Ekestubbe, Lovisa and Forssten, Maximilian Peter and Cao, Yang and Sarani, Babak and Mohseni, Shahin}, year = {2025}, journal = {European Journal of Trauma and Emergency Surgery}, volume = {51}, number = {1}, doi = {10.1007/s00068-025-02860-4}, url = {1956044}, language = {eng}, publisher = {Urban und Vogel Medien und Medizin Verlagsgesellsc}, keywords = {conservative management; machine learning; morbidity; permutation importance; rib fracture}, abstract = {PURPOSE: Rib fractures, common in blunt chest trauma, affect 10% of trauma patients and are linked to increased pulmonary morbidity and mortality. This study applies machine learning to identify predictors of complications in conservatively managed rib fracture patients.METHODS: Data from the 2013-2021 American College of Surgeons' Trauma Quality Improvement Program included adults (≥ 18 years) with isolated thoracic injury from blunt trauma and conservatively managed rib fractures. Variables included demographics, comorbidities, injury severity, injury patterns, admission vitals, and complications. The permutation importance method identified top predictors of in-hospital complications.RESULTS: Of 321,355 rib fracture patients, 183,303 (57.0%) had isolated rib fractures. The five primary predictors of complications in all rib fracture patients were age, Glasgow Coma Scale (GCS) on admission, Revised Cardiac Risk Index (RCRI), chronic obstructive pulmonary disease (COPD), and alcohol use disorder. For isolated rib fracture patients, the same predictors applied but in the order: age, RCRI, GCS, COPD, and alcohol use disorder. A logistic regression model using these predictors showed acceptable discriminative capacity for complications in the full cohort [AUC (95% CI): 0.72 (0.71-0.72)] and isolated rib fracture patients [AUC (95% CI): 0.72 (0.71-0.73)].CONCLUSION: Cardiovascular risk, age, and level of consciousness on admission are key predictors of complications in conservatively managed rib fracture patients. Though complication rates remain low overall, elderly patients with multiple cardiovascular risk factors face a heightened risk of deterioration.}, issn = {1863-9933} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alijanpourotaghsaraamirreza_2025, title = {Morphometric Analysis of Neocortical and Infratentorial Structures : Genetic and Environmental Insights from a Twin Neuroanatomical Study}, author = {Alijanpourotaghsara, Amirreza and Vessal, Arsalan and Alijanpour, Amirmasoud and Strelnikov, David and Piroska, Marton and Persely, Aliz and Jokkel, Zsofia and Szalontai, Laszlo and Forgo, Bianka and Kozak, Lajos Rudolf and Bekesy-Szabo, Adam and Maurovich-Horvat, Pal and Tarnoki, David Laszlo and Tarnoki, Adam Domonkos}, year = {2025}, journal = {Medicina}, volume = {61}, number = {2}, doi = {10.3390/medicina61020261}, url = {1940869}, language = {eng}, publisher = {MDPI}, keywords = {brain morphology; cortical thickness; genetic factors; heritability; neuroimaging}, abstract = {Background and Objective: Brain morphometry is shaped by a complex interplay of genetic and environmental factors, including physiological and neuropsychiatric conditions. These influences can vary across distinct brain regions, yet the precise contributions of genetics and environment to regional variation in healthy brains remain poorly understood. This study examines the heritability of specific brain structures to provide deeper insights into their development.Materials and Methods: We studied 118 healthy adult twins from the Hungarian Twin Registry using T1-weighted magnetic resonance imaging (T1W MRI) and the volBrain pipeline for structural measurements.Results: In all regions, monozygotic (MZ) twins showed a higher resemblance than dizygotic (DZ) twins in total brainstem and cerebellar volumes, with significant heritability (A: 90.5-92.6%) and minimal unique environmental effects (E: <1%). For supratentorial regions, regarding the total gray matter volume, all regions exhibited high heritability (A: 74.5-92.4%) and minimal environmental influence (E: <1.5%). In average cortical thickness analysis, the frontal lobe, temporal lobe, and pre-central gyrus were influenced by shared and unique environmental factors (C: 63-66.5%; E: 33.4-37%), whereas genetics were more prominent in the parietal lobe, occipital lobe, and post-central gyrus (A: 67.7-85%; E: 15-32.3%).Conclusions: Genetics strongly influence cortical gray matter volume in supratentorial regions (both total and regional), as well as the total brainstem volume and the total and cortical gray matter volumes of the cerebellum in infratentorial regions. This genetic influence extends to the average cortical thickness of the parietal lobe, post-central gyrus, and occipital lobe, while the frontal lobe, temporal lobe, and pre-central gyrus are more affected by environmental factors. These findings emphasize the importance of understanding region-specific genetic and environmental contributions to brain structure, which could guide personalized therapeutic and preventive strategies for neurological conditions.}, issn = {1010-660X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_beharryjames_2025, title = {Mortality in ischaemic stroke patients without standard modifiable risk factors : An analysis of the Riksstroke registry}, author = {Beharry, James and Yogendrakumar, Vignan and Barros, Guilherme W. F. and Davis, Stephen M. and Norrving, Bo and Figtree, Gemma A. and Donnan, Geoffrey and von Euler, Mia and Eriksson, Marie}, year = {2025}, journal = {European Stroke Journal}, volume = {10}, number = {3}, pages = {813--821}, doi = {10.1177/23969873241309516}, url = {1926128}, language = {eng}, publisher = {Sage Publications}, keywords = {stroke; death; dependency; mortality; risk factors}, abstract = {INTRODUCTION: Little is known of the long-term prognosis of patients with acute ischaemic stroke in the absence of standard modifiable stroke risk factors (SMoRFs). In acute coronary syndromes, patients without modifiable risk factors have a higher mortality rate. We analysed data from the Swedish Stroke Register to determine survival of patients without SMoRFs following an ischaemic stroke.PATIENTS AND METHODS: We identified adult patients with first-presentation acute ischaemic stroke between 2010 and 2020. Patients were considered to possess a SMoRF if they had one of: hypertension, diabetes, hyperlipidaemia, atrial fibrillation or an active smoking history. We compared mortality in patients with and without SMoRFs following first-presentation ischaemic stroke using cox regression models. We also assessed the combined endpoint death and dependency (mRS 3-6) at 3 months via logistic regression models.RESULTS: Of 152,588 patients with ischaemic stroke, hypertension (58.7%) and atrial fibrillation (27.3%) were the most common risk factors. 34,019 patients (22.3%) had no SMoRFs. After a first-presentation ischaemic stroke, patients without SMoRFs had a lower risk of death than patients with one or more SMoRFs (HR 0.58 [95% CI 0.57-0.59]). The absence of SMoRFs was associated with lower odds of death and dependency at 3 months in logistic regression models (OR 0·60 [95% CI 0.58-0.62]).CONCLUSION: One in five patients with acute ischaemic stroke had no standard modifiable stroke risk factors. These patients have lower risk of death compared to patients with one or more SMoRFs.}, issn = {2396-9873} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_thortindra_2025, title = {”Most of these glaciers will only remain in images” : A Visual Analysis of Transforming Mountain Landscapes in Space-Time Compressed Photography}, author = {Thor, Tindra}, year = {2025}, url = {2022044}, language = {eng} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_thortindra_2025_1, title = {”Most of these glaciers will only remain in images” : A Visual Analysis of Transforming Mountain Landscapes in Space-Time Compressed Photography}, author = {Thor, Tindra}, year = {2025}, url = {2022045}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johnstoneleanne_2025_3, title = {Motivating sustainable behaviour in the workplace through control}, author = {Johnstone, Leanne and Beusch, Peter}, year = {2025}, journal = {Journal of Management Control}, doi = {10.1007/s00187-025-00390-z}, url = {1955316}, language = {eng}, publisher = {Springer}, keywords = {incentives; management control; motivations; regulatory styles and processes; self-determination continuum; sustainable behaviour; m19; m40; m49}, abstract = {While social and environmental accounting studies often focus on organisational-level motivations to engage in sustainability, less is known about how controls are designed to motivate individuals (managers and non-managers) to engage in sustainable workplace behaviours that align with organisational goals and, ultimately, wider planetary concerns. Drawing on the concept of motivation and its relation to control, this study aims to deepen the understanding of the role of sustainability controls for behavioural alignment across different contexts. This is achieved through the production of a conceptual typology that elaborates: What, when and how should controls be used to motivate organisational and individual behaviours that align for sustainability performance? Drawing on (1) the classification types of organisational-level ethical motivations and (2) the regulatory styles and processes of the self-determination continuum, examples are provided from two independent case studies to illustrate the types of controls that can be used by organisations to motivate the sustainable behaviours of their employees; behaviours that extend beyond the workplace into the personal sphere. The typology has analytical potential for future sustainability control research as well as practical implications in that managers can assess organisational and employee positions and then design controls accordingly to support behavioural alignment. It is important for understanding the behavioural alignment function of control by elaborating different types of incentives that can motivate sustainable behaviour. Finally, this approach may help reduce tensions in management control by connecting individual, organisational and, ultimately, planetary levels in sustainability efforts.}, issn = {2191-4761} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_johnstoneleanne_2025_4, title = {Motivating sustainable behaviour in the workplace through control}, author = {Johnstone, Leanne}, year = {2025}, url = {1962349}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_urberglinnea_2025_1, title = {Motstånd, Motkultur och Miljöfrågor : En etnografisk studie av ungdomars reaktioner mot utbildning och hållbar utveckling}, author = {Urberg, Linnea}, year = {2025}, journal = {Nordisk tidsskrift for ungdomsforskning}, volume = {6}, number = {1}, pages = {1--19}, doi = {10.18261/ntu.6.1.5}, url = {2008552}, language = {swe}, publisher = {Scandinavian University Press}, keywords = {resistance; counterculture; sustainable development; environmental and sustainability education; motstånd; motkultur; hållbar utveckling; miljö- och hållbarhetsutbildning}, abstract = {Miljö- och hållbarhetsfrågor kan vara värdeladdade, skapa konflikter och ge upphov till motstånd, vilket också märks bland ungdomar. Detta blir särskilt tydligt inom miljö- och hållbarhetsutbildning. Studien bidrar med en empiriskt och teoretiskt förankrad förståelse av tre former av motstånd: mot utbildning, mot hållbar utveckling samt mot miljö- och hållbarhetsutbildning. Vid analys av dessa former av motstånd med stöd i teorier om motstånd och motkultur visar resultaten att motstånd inte enbart handlar om avvisande av undervisningens innehåll, utan utgör en kritisk respons på hur normer, värderingar och samhällsvisioner institutionaliseras i skolan. Studien belyser därmed hur ungdomars motstånd kan förstås både som en reaktion på maktförhållanden inom utbildningen och som ett svar på repressiva ideologiska mönster som underordnar dem. De tre formerna av motstånd som identifierats i studien visar hur unga pojkar positionerar sig i relation till både skolans fostrande funktion och depolitiserade frågor som formar bilden av hållbar utveckling och miljöengagemang. Ur ett vidare perspektiv visar resultaten hur frågor om hållbar utveckling kan vara starkt kopplade till elevernas upplevelser av uppoffringar och är villkorade av sociala, kulturella och materiella resurser.;Environmental and sustainability issues can be value-laden, generate conflicts, and elicit resistance, and such resistance is also observed among youth. This is particularly evident in environmental and sustainability education. The study contributes an empirically and theoretically grounded understanding of three forms of resistance: resistance to education, resistance to environmental and sustainability issues, and resistance to environmental and sustainability education. By analyzing these forms through theories on resistance and counterculture, the findings demonstrate that resistance is not solely a rejection of the curriculum content but constitutes a critical response to the ways in which norms, values, and societal visions are institutionalized in schools. The study thus highlights how youth resistance can be understood both as a reaction to power relations within education and as a response to repressive ideological patterns that subordinate them. The three forms of resistance identified in this study illustrate how young males who resist position themselves in relation to both the educative function of the school and the politicized issues that shape perceptions of sustainable development and environmental engagement. From a broader perspective, the results indicate that issues of sustainable development are intertwined with students’ experiences of sacrifice and conditioned by social, cultural, and material resources.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_solandertove_2025_1, title = {Much Ado About Gender}, author = {Solander, Tove}, year = {2025}, journal = {Archives of Sexual Behavior}, volume = {54}, pages = {3897--3900}, doi = {10.1007/s10508-025-03330-z}, url = {2015873}, language = {eng}, publisher = {Springer}, issn = {0004-0002} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_holmberganna_2025, title = {Multigenerational family coaggregation study of obsessive-compulsive disorder and cardiometabolic disorders}, author = {Holmberg, Anna and Pol-Fuster, Josep and Kuja-Halkola, Ralf and Larsson, Henrik and Lichtenstein, Paul and Chang, Zheng and D'Onofrio, Brian M. and Brikell, Isabell and Sidorchuk, Anna and Isomura, Kayoko and Crowley, James J. and Martinsson, Lina and Rück, Christian and Mataix-Cols, David and Fernández de la Cruz, Lorena}, year = {2025}, journal = {BMJ Mental Health}, volume = {28}, number = {1}, doi = {10.1136/bmjment-2024-301323}, url = {1930033}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, abstract = {BACKGROUND: Obsessive-compulsive disorder (OCD) is associated with an increased risk of morbidity and mortality due to cardiometabolic disorders. Whether this association is driven by familial factors is unknown. This population-based family study explored the familial co-aggregation of OCD and cardiometabolic disorders.METHODS: We identified 6 049 717 individuals born in Sweden between 1950 and 2008, including 50 212 individuals with OCD, and followed them up to 2020. These individuals were linked to their mothers, fathers, full siblings, maternal and paternal half siblings, aunts, uncles and cousins. We estimated the risk of cardiovascular diseases (CVD) and metabolic disorders (including obesity, type 2 diabetes and hyperlipidaemia), comparing the relatives of probands with and without OCD. Cox proportional hazards regression models, incorporating time-varying exposures, estimated HRs.RESULTS: OCD was associated with an increased risk of CVD (HR 1.47; 95% CI 1.43 to 1.51), obesity (HR 1.69; 95% CI 1.63 to 1.74), type 2 diabetes (HR 2.01; 95% CI 1.90 to 2.12) and hyperlipidaemia (HR 1.42; 95% CI 1.33 to 1.52). The relatives of probands with OCD exhibited small increased risks of CVD (HRs from 1.01 to 1.11) and obesity (HRs from 1.03 to 1.20). Slightly increased risks for type 2 diabetes were observed in mothers (HR 1.11; 95% CI 1.07 to 1.15) and full siblings (HR 1.12; 95% CI 1.05 to 1.20), while for hyperlipidaemia it was only observed in mothers (HR 1.06; 95% CI 1.02 to 1.10).CONCLUSIONS: Our results do not support a major contribution of familial factors to the association between OCD and cardiometabolic disorders, suggesting a more prominent role of unique environmental factors.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_erikssongran_2025_1, title = {Multimodal analys av audiovisuell kommunikation}, author = {Eriksson, Göran and Kenalemang, Lame Maatla}, year = {2025}, pages = {275--302}, url = {1998075}, language = {swe}, publisher = {Studentlitteratur AB} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_schreitertim_2025_1, title = {Multimodal Interaction and Intention Communication for Industrial Robots}, author = {Schreiter, Tim and Rudenko, Andrey and Rüppel, Jens V. and Magnusson, Martin and Lilienthal, Achim J.}, year = {2025}, url = {1941553}, language = {eng}, abstract = {Successful adoption of industrial robots will strongly depend on their ability to safely and efficiently operate in human environments, engage in natural communication, understand their users, and express intentions intuitively while avoiding unnecessary distractions. To achieve this advanced level of Human-Robot Interaction (HRI), robots need to acquire and incorporate knowledge of their users’ tasks and environment and adopt multimodal communication approaches with expressive cues that combine speech, movement, gazes, and other modalities. This paper presents several methods to design, enhance, and evaluate expressive HRI systems for non-humanoid industrial robots. We present the concept of a small anthropomorphic robot communicating as a proxy for its non-humanoid host, such as a forklift. We developed a multimodal and LLM-enhanced communication framework for this robot and evaluated it in several lab experiments, using gaze tracking and motion capture to quantify how users perceive the robot and measure the task progress}, file = {https://oru.diva-portal.org/smash/get/diva2:1941553/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_reinikainenelisa_2025, title = {Municipal chief nurses’ responsibilities and decision-making to ensure patient safety in municipal healthcare : a qualitative descriptive study}, author = {Reinikainen, Elisa and Kihlgren, Annica and Pejner, Margaretha Norell and Windahl, Jenny}, year = {2025}, journal = {BMC Nursing}, volume = {24}, number = {1}, doi = {10.1186/s12912-025-03295-3}, url = {1964256}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {decision-making; municipal healthcare; municipal chief nurse; patient safety}, abstract = {Background: The structure and organisation of Swedish municipal healthcare has been criticised for being fragmented and inefficient. Municipal chief nurses hold overall responsibility for patient safety within municipal healthcare, yet they lack authority over finances and staffing. Their role and responsibilities have not been examined in previous studies. The aim of this study was therefore to explore municipal chief nurses' experiences of obstacles and possibilities in decision-making to ensure patient safety in municipal healthcare.Methods: A qualitative descriptive design was used. Data were collected through 15 individual semi-structured interviews with municipal chief nurses, and the results were analysed via qualitative content analysis.Results: The data analysis yielded an overall theme: Navigating decision-making to ensure patient safety. This overall theme comprised three underlying categories: Unclear role and understanding of the assignment; Impact of organisational level on decision-making mandate; and Knowledge, competence, and experience in patient safety work.Conclusion: There was a lack of clarity regarding the municipal chief nurses' assignments in the municipal healthcare organisation. The participants felt that their organisations had insufficient knowledge of healthcare, and it became evident that organisational placement and their own competence affected their decision-making regarding healthcare and patient safety. Some noted that the organisation's shortcomings could be advantageous, providing them with a scope for action. Consequently, the informants had to navigate in the system and find alternative ways to ensure patient safety.Clinical trial registration: Not applicable.}, file = {https://oru.diva-portal.org/smash/get/diva2:1964256/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sataenhognel_2025_1, title = {Municipal risk communication challenges in the Nordic context : Organizing risk ownership}, author = {Sataøen, Hogne L. and Østgaard Skotnes, Ruth and Hansen, Kåre and Eriksson, Mats}, year = {2025}, journal = {Risk, Hazards & Crisis in Public Policy}, volume = {16}, number = {1}, doi = {10.1002/rhc3.12289}, url = {1829949}, language = {eng}, publisher = {Policy Studies Organization}, keywords = {municipalities; nordic countries; risk communication; risk ownership}, abstract = {At a time when disasters, pandemics, pollution, and other crises gain prominence, local governments bear a crucial responsibility for effective risk communication. Yet, there remains a gap in our understanding of how municipalities approach risk communication before a crisis occurs. This qualitative study, involving seven focus groups and 29 semistructured interviews across two Nordic countries, raises questions about ownership of municipal risk communication: What challenges do municipalities face in managing ownership in risk communication? How does the organization of communication influence municipal risk communication? The results underscore three key considerations: First, there is a critical need for municipalities to engage in definitional clarification of risk and crisis communication. Establishing a shared understanding is paramount for effective communication strategies. Second, reframing uncertainty in municipal risk communication ownership as an opportunity is suggested. Embracing the inherent uncertainties and dependencies can offer a valuable perspective. Lastly, recognizing the underappreciation of risk communication emphasizes the imperative for municipal decision makers to address resource allocation issues. This involves ensuring that communication professionals have the confidence and resources needed, vis-à-vis other functions involved in risk management.}, file = {https://oru.diva-portal.org/smash/get/diva2:1829949/FULLTEXT01.pdf} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_elmazoskairis_2025_1, title = {Music and Hearing Health : A Study on Music Listening Behaviors and Hearing-Related Risks Among Young People}, author = {Elmazoska, Iris}, year = {2025}, url = {1967794}, language = {eng}, publisher = {Örebro University}, keywords = {hearing health; music listening; headphones; high-frequency; dpoae; meaning-making; auditory symptoms; attitudes to noise; children; adolescents}, abstract = {Concerns about noise-induced hearing loss among young people are increasing as young people frequently engage in music listening for extended periods of time and/or at high sound levels. The aim of this thesis was to investigate associations between music listening and hearing health among young people. Study I is a systematic review investigating associations between hearing function and recreational noise (focus on music exposure) among 10 – 30 year olds. Study II is a qualitative study exploring the meaning of music in the daily life of participant’s (15 – 19 – year – olds) and how young people understand hearing-related risks. Study III is a cross-sectional study examining associations between measured headphone sound pressure levels (SPLs) with hearing thresholds and distortion product otoacoustic emissions (DPOAEs) among 10 – 20 year olds. Study IV is a cross-sectional study investigating how attitudes to noise/loud music and auditory symptoms (tinnitus, sound sensitivity etc.,) relate to hearing-and sound level measurements among 10 – 20 year olds. Study I showed that some previous research has found associations between music exposure with worse extended high-frequency (EHF) thresholds and reduced DPOAEs. However, consistent evidence of long-term effects remains limited, partly due to differing methods of exposure assessment across studies. Study II showed that music is an integral part of the participants’ daily life and valuable for emotional regulation. Despite an awareness of the potential risks, the benefits of music outweighed any concerns about hearing health. Study III showed that older participants (age ≥15 years) had some slightly elevated EHF thresholds and reduced DPOAEs, but no statistically significant associations were found between measured SPLs and hearing outcomes. Study IV showed that more positive attitudes to noise/loud music were significantly associated with higher measured SPLs and longer daily listening durations (self-reported). Most auditory symptoms were not associated with hearing-or sound level measurements, except greater need for auditory recovery, which was associated with reduced DPOAEs. The overall results point to the importance of prevention efforts as potentially risky music listening behaviors may indicate early auditory changes related to noise exposure.}, file = {https://oru.diva-portal.org/smash/get/diva2:1967794/FULLTEXT01.pdf;https://oru.diva-portal.org/smash/get/diva2:1967794/FULLTEXT02.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_12, title = {Nancy Fraser}, author = {Johansson Wilén, Evelina}, year = {2025}, url = {2000847}, language = {swe}, publisher = {Daidalos} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_eskilsonolof_2025, title = {Nanocellulose Wound Dressings with Integrated Protease Sensors for Detection of Wound Pathogens}, author = {Eskilson, Olof and Wiman, Emanuel and Reustle, Nina and Langwagen, Jakob and Sotra, Zeljana and Svärd, Anna and Selegård, Robert and Baş, Yağmur and Berglund, Linn and Oksman, Kristiina and Bengtsson, Torbjörn and Junker, Johan P. E. and Khalaf, Hazem and Aili, Daniel}, year = {2025}, journal = {ACS Sensors}, volume = {10}, number = {6}, pages = {3953--3963}, doi = {10.1021/acssensors.4c03428}, url = {1959583}, language = {eng}, publisher = {American Chemical Society (ACS)}, keywords = {bacteria; gold nanoparticles; nanocellulose; protease; wound infection}, abstract = {Wound infections result in delayed healing, morbidity, and increased risks of sepsis. Early detection of wound infections can facilitate treatment and reduce the need for the excessive use of antibiotics. Proteases are normally active during the healing process but are overexpressed during infection as part of the inflammatory response. Proteases are also produced by the bacteria infecting the wounds, making proteases a highly relevant biomarker for infection monitoring. Here, we show a fluorescence turn-on sensor for real-time monitoring of protease activity in advanced nanocellulose wound dressings for rapid detection of wound pathogens. Colloidal gold nanoparticles (AuNPs) were adsorbed on bacterial cellulose (BC) nanofibrils by using a carefully optimized self-assembly process. The AuNPs could either be homogeneously incorporated in BC dressings or 3D printed in wood-derived cellulose nanofiber (CNF) dressings using a BC-AuNP ink. The BC-adsorbed AuNPs were subsequently functionalized with fluorophore-labeled protease substrates. Cleavage of the substrates by proteases produced by the wound pathogens Staphylococcus aureus and Pseudomonas aeruginosa resulted in a significant increase in fluorescence that correlated with the growth phase of the bacteria. Wound dressing with integrated sensors for the detection of proteolytic activity can enable the sensitive and rapid detection of infections, allowing for optimization of treatment and reducing the risks of complications.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alijagicandi_2025_2, title = {Nanoplastics drive toxicity under co-exposure with perfluorooctanesulfonic acid in human intestinal cells}, author = {Alijagic, Andi and Särndahl, Eva and Kotlyar, Oleksandr and Karlsson, Patrik and Duberg, Daniel and Scherbak, Nikolai and Pinsino, Annalisa and Engwall, Magnus and Hyötyläinen, Tuulia}, year = {2025}, journal = {Environmental Chemistry Letters}, volume = {23}, number = {5}, pages = {1161--1169}, doi = {10.1007/s10311-025-01847-2}, url = {1957286}, language = {eng}, publisher = {Springer}, keywords = {metabolomics; phenomics; cell painting; human intestinal cell line; perfluorooctanesulfonic acid; novel exposure biomarkers}, abstract = {Per- and polyfluoroalkyl substances and nanoplastics frequently co-occur in environmental matrices, yet the effects of co-exposure on cellular responses upon ingestion are poorly understood. Here, we exposed human intestinal Caco-2 cells to perfluorooctanesulfonic acid, nanoplastics, and their combination. Cell painting-based phenomics was used to map phenotypic alterations across subcellular structures, and untargeted metabolomics using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry was employed to assess metabolic changes. Results show that perfluorooctanesulfonic acid predominantly affected the actin cytoskeleton, Golgi apparatus, and plasma membrane, while nanoplastics primarily targeted mitochondria. Combined exposure disrupted the endoplasmic reticulum, RNA, and mitochondria. Perfluorooctanesulfonic acid reduced levels of carnitines, free fatty acids, nucleotides, and sugars, whereas nanoplastics inhibited ceramides, triglycerides, sphingomyelins, and additional free fatty acids. Combined exposure produced a metabolic profile resembling that of nanoplastics, with specific differences attributed to perfluorooctanesulfonic acid. Overall, nanoplastics appear as the main drivers of the co-exposure effects.}, issn = {1610-3653} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_grimbeekmarinette_2025, title = {Narrative Accretion and Overwhelming Anthropocenic Entanglement in Lucy Ellmann’s Ducks, Newburyport}, author = {Grimbeek, Marinette}, year = {2025}, url = {1952499}, language = {eng}, abstract = {Lucy Ellmann’s expansive Ducks, Newburyport (2019) is pervaded by frequently gendered tensions, for instance related to motherhood and domestic labor, the role of the individual in the collective, as well as abundance and middle-class consumption in an age of extinction and scarcity. The majority of the novel comprises a single sentence, well over nine hundred pages long, which presents the associative stream-of-consciousness musings of an unnamed Ohioan mother as she performs her daily tasks. This sprawling sentence comprises lists, tangents and snatches of lyrics and is punctuated by the repeated phrase “the fact that” which introduces each new turn of thought. Other interruptions include a section typographically presented as free verse, and the stylistically more conventional third-person narrative centered on a mountain lioness which appears in several parts. In this presentation, I consider the manner in which the angry, rambling first-person sentence functions as a narrative of accretion that both represents and reproduces the “infowhelm” identified by Heather Houser as characteristic of Anthropocenic information overload. Through the seemingly unordered accretion of information or “facts”, the first-person narrator explores her entanglement in multiple spheres, including motherhood, domesticity and family life, American history and contemporary politics, and environmental crises. This relentless accretion also creates a sense of overwhelming Anthropocenic entanglement. However, the highly gendered subjectivity and lived experience of the narrator, coupled with her outrage at the state of the world and relative political impotence, result in a notion of entanglement that is at odds with the often-valorized entanglement of new-materialist becoming. Although some aspects of the entanglement experienced and described by the narrator are empowering, as indicated by the overall narrative parallel between the human mother and the mountain lioness, entanglement is instead regularly associated with entrapment and involuntary complicity in anthropogenic crisis. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hedbergjakob_2025, title = {Nasogastric tube after oesophagectomy and risk of anastomotic leak : a Nordic, multicentre, open-label, randomised, controlled, non-inferiority trial}, author = {Hedberg, Jakob and Kauppila, Joonas and Aahlin, Eirik Kjus and Edholm, David and Johnsen, Gjermund and Johansson, Jan and Lagergren, Pernilla and Lindblad, Mats and Lindberg, Fredrik and Helminen, Olli and Löfdahl, Per and Førland, Dag Tidemann and Vikhammer, Mads and de Heer, Pieter and Sundbom, Magnus and Szabo, Eva and Åkesson, Oscar and Nilsson, Magnus and Nilsson, Albert and Achiam, Michael and Mala, Tom}, year = {2025}, journal = {The Lancet Regional Health: Europe}, volume = {57}, doi = {10.1016/j.lanepe.2025.101411}, url = {1990061}, language = {eng}, publisher = {Elsevier}, keywords = {oesophageal cancer; oesophagectomy; nasogastric tube; anastomotic leak; complications; postoperative care}, abstract = {Background: Oesophagectomy, a corner stone in curative treatment of oesophageal cancer, is a complex procedure with high complication rates. Postoperative gastric tube decompression is debated and some centres are abandoning routine nasogastric (NG) tube use. We hypothesised that postoperative NG tube removal is non-inferior to five days of NG tube decompression, with regard to the risk of anastomotic leak.Methods: In this open-label, non-inferiority randomised controlled trial across 12 hospitals in Sweden, Norway, Denmark and Finland, participants treated for oesophageal or gastroesophageal junctional cancer with oesophagectomy were randomly assigned (1:1) to no postoperative NG tube or five days of NG tube decompression. Anastomotic leak was the primary outcome and secondary outcomes included pneumonia and length of hospital stay. Analyses were performed on the intention to treat and per protocol populations and non-inferiority for anastomotic leak was defined as a risk difference below 9%. ISRCTN.com registration ISRCTN39935085.Findings: Between January 1st 2022 and March 27th 2024, 448 patients were randomly assigned, 217 to no postoperative NG tube and 231 to five days NG tube treatment. The mean age was 67.5 (standard deviation (SD) 9.8) years and 367 (81.9%) were males. Non-inferiority with regard to anastomotic leak for no NG tube decompression could not be shown with 48 patients (22.1% (95% confidence interval (CI) 16.8%, 28.2%)) having anastomotic leak compared to 35 (15.2% (95% CI 10.8%, 20.4%)) with five days of NG tube decompression, a risk difference of-7.0% (95% CI-14.4%, 0.00%), pnon-inferiority 0.30. In a Supplementary analysis, patients had a lower risk of anastomotic leak if postoperative NG decompression was used. Rate of other complications, e.g., pneumonia, were similar between groups. In a per-protocol analysis, the risk difference was-11.3% to the advantage of NG tube (95% CI, -19.1,-0.3%).Interpretation: We could not establish safety (increased risk of anastomotic leak) and therefore do not support omission of NG tube after oesophagectomy. } } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_quennerstedtann_2025_2, title = {National curricula as promoters or obstructers of human rights education - the example of Sweden}, author = {Quennerstedt, Ann}, year = {2025}, pages = {182--197}, url = {1927501}, language = {eng}, publisher = {Taylor & Francis}, abstract = {This chapter examines the role of curriculum in the realisation of human rights education (HRE) in formal schooling. Drawing on text analysis of the Swedish national curricula, the extent to which distinct goals and subject content can be found is presented. The analysis focuses on the HRE elements knowledge, values and action capacity, and whether the curricula promote or obstruct the realisation of these. The findings show that the curricula contain direction for all three elements, and accordingly promote a full HRE in a general sense. However, troublesome differences between the formulation of goals and content for knowledge on the one hand, and for values and action capacity on the other, are found. These differences concern level of concretion and progression, achievement requirement and clear identification of responsibility for HRE. The Swedish curricula thereby promote a HRE that leans towards the knowledge element and obstruct education aiming towards development of values and action capacity.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sandinsven_2025, title = {National trends in offspring birth size in pregnancies with maternal type 1 diabetes in Sweden}, author = {Sandin, Sven and Järnbert-Pettersson, Hans and Simmons, David and Backman, Helena and Persson, Martina}, year = {2025}, journal = {Diabetes Research and Clinical Practice}, volume = {226}, doi = {10.1016/j.diabres.2025.112350}, url = {1981279}, language = {eng}, publisher = {Elsevier}, keywords = {large for gestational age; neonatal adiposity; type 1 diabetes}, abstract = {OBJECTIVE: Despite major medical and public health efforts to reduce excess fetal growth in type 1 diabetes (T1D), large population-based studies assessing the population-level effects are lacking. We assessed temporal trends in the overall distribution of birthweights (BW) and ponderal index (PI) in offspring of T1D mothers, and the impact of maternal BMI.RESEARCH DESIGN, AND METHODS: Population-based cohort study of all live-born infants to T1D mothers between 1998 and 2016 across Sweden, using data from national registers. Main outcome measures were percentiles of BW and PI. We compared the first 10 years, 1998-2007 (period 1), with the last 10 years, 2008-2016 (period 2), using quantile regression and adjusting for maternal characteristics and hypertensive disease between periods.RESULTS: Among 6,485 offspring of T1D mothers, the birth weights and PI distributions did not change between the two study periods, neither for the heaviest infants, LGA, nor for the smallest infants, independent of maternal first trimester BMI. The proportion of LGA remained at 61%.CONCLUSION: There was no improvement over a 20-year period in the distributions of birth weights or PÍs in offspring of T1D mothers in Sweden, unrelated to maternal BMI. Overall, 61% of offspring of T1D mothers were LGA.}, issn = {0168-8227} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dolkdanielcastellanos_2025, title = {Nationwide incidence of anterior cruciate ligament reconstruction in higher-level athletes in Sweden : a cohort study from the Swedish National Knee Ligament Registry linked to six sports organisations}, author = {Dolk, Daniel Castellanos and Hedevik, Henrik and Stigson, Helena and Wretenberg, Per and Kvist, Joanna and Stalman, Anders}, year = {2025}, journal = {British Journal of Sports Medicine}, volume = {59}, number = {7}, pages = {470--479}, doi = {10.1136/bjsports-2024-108343}, url = {1918276}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {anterior cruciate ligament; knee injuries; sports medicine; women in sport}, abstract = {Objective: To determine and compare the incidence rate (IR) of anterior cruciate ligament reconstruction (ACL-R) among higher-level athletes across six sports in the Swedish National Knee Ligament Registry (SNKLR).Methods: Patient data from the SNKLR, between 2005 and 2020, was linked to team and event data of six sports (football, handball, basketball, ice hockey, floorball and alpine sports) to identify higher-level athletes aged 15-40 with ACL-R. Unadjusted and adjusted IR ratios (IRRs) with 99% CIs were calculated between sports, sex, age and divisions.Results: Female athletes had a 3.3 times higher ACL-R IR compared with males (1.08 vs 0.32, IRR=3.33, 99% CI: 2.65 to 4.19) per 1000 athlete exposures (AE). Basketball had the largest difference in ACL-R IR per 1000 AE between females and males (1.26 vs 0.22, IRR=5.69, 99% CI: 2.79 to 11.60). Female second-division athletes had higher ACL-R IR per 1000 AE compared with female highest-division athletes (1.27 vs 0.76, IRR=1.67, 99% CI: 1.30 to 2.15). No significant association between age and IR was observed. Compared with football, lower ACL-R IR was observed in floorball and ice hockey in females, as well as in floorball, basketball and ice hockey in males.Conclusion: Female athletes had higher ACL-R IRs than males and second-division female athletes had higher ACL-R IRs than highest-division female athletes. Lower ACL-R IRs were observed in floorball and ice hockey compared with football for both sexes. The remaining sports had ACL-R IRs similar to football, except basketball where rates were lower for male athletes.}, issn = {0306-3674} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_brunetsofia_2025, title = {Nationwide multicentre study of Nanopore long-read sequencing for 16S rRNA-species identification}, author = {Brunet, Sofia and Grankvist, Anna and Jaen-Luchoro, Daniel and Bergdahl, Maria and Tison, Jean-Luc and Wester, Annica and Elfving, Karin and Brandenburg, Jule and Gullsby, Karolina and Lindsten, Christoffer and Arvidsson, Lars-Ola and Larsson, Helena and Eilers, Hinnerk and Strand, Anna Söderlund and Lannefors, Mimi and Keskitalo, Johanna and Rylander, Felicia and Welander, Jenny and Bergman Jungestrom, Malin and Geörg, Miriam and Kaden, Rene and Karlsson, Ida and Linde, Anna-Malin and Mernelius, Sara and Berglind, Linda and Feuk, Lars and Kerje, Susanne and Karlsson, Linda and Sjödin, Andreas and Guerra-Blomqvist, Lina and Wallin, Frans and Fagerström, Anna and Vondracek, Martin and Mölling, Paula and Hallbäck, Erika Tång}, year = {2025}, journal = {European Journal of Clinical Microbiology and Infectious Diseases}, volume = {44}, number = {8}, pages = {1907--1916}, doi = {10.1007/s10096-025-05158-w}, url = {1957690}, language = {eng}, publisher = {Springer}, keywords = {16s rrna; bacterial identification; emu; genomic medicine sweden; nanopore sequencing}, abstract = {PURPOSE: Recent improvements in Nanopore sequencing chemistry has made it a promising platform for long-read 16S rRNA sequencing. This study evaluated its clinical utility in a nationwide collaboration coordinated by Genomic Medicine Sweden.METHODS: Thirteen mock samples comprised of various bacterial strains and an External Quality Assessment (EQA) panel from QCMD (Quality Control for Molecular Diagnostics) were analysed by 20 microbiological laboratories across Sweden, using the recent v14 chemistry. Most laboratories generated full-length 16S rRNA sequencing libraries using an optimized protocol for the 16S Barcoding Kit 24, while two laboratories employed in-house PCR coupled with the Ligation Sequencing Kit. The commercial 16S bioinformatic pipeline from 1928 Diagnostics (1928-16S) was evaluated and compared with the open-sourced gms_16S pipeline that is based on the EMU classification tool (GMS-16S).RESULTS: Seventeen out of 20 laboratories successfully sequenced and analysed the samples. Laboratories that used sodium acetate-containing elution buffers faced compatibility issues during library construction, resulting in reduced read count. High bacterial load samples were generally well-characterized, whereas hard-to-lyse bacteria such as Gram-positive strains were detected at lower abundance. The GMS-16S tool provided improved species-level identification compared to the 1928-16S pipeline, particularly for closely related taxa within the Streptococcus and Staphylococcus genera.CONCLUSION: Nanopore sequencing demonstrated promising potential for bacterial identification in a clinical setting. The results prompt further optimization of the protocol to improve detection of a broader range of species. This multicentre study highlights the feasibility of implementing Nanopore sequencing into clinical microbiological laboratories, for improved national precision diagnostics.}, issn = {0934-9723}, file = {https://oru.diva-portal.org/smash/get/diva2:1957690/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_mohammedomard_2025_1, title = {Natural frequency shifting using water-based technique}, author = {Mohammed, Omar D. and Limbos, Stephen J. and Mahmood, QatrAlnada and Alherz, Hala}, year = {2025}, volume = {57}, doi = {10.1121/2.0002155}, url = {1998714}, language = {eng}, publisher = {Acoustical Society of America (ASA)}, abstract = {Avoiding resonance, which can occur when the system is excited by a frequency equal to or close to one of the system’s natural frequencies, is crucial to ensure a safe operational system. It is essential to ensure that the system runs at a frequency away from the natural frequencies, which are the resonance frequencies. Sometimes, it is not feasible to vary the operational frequency to avoid the resonance frequencies. Therefore, the current research presents an experimental technique, namely the water-based technique for mass variation, to introduce a method of shifting the natural frequency. A beam system, with a force exciter, accelerometer and two water tanks, is studied as a case study. The mass variation can be used to shift the natural frequency away from the excitation frequency. Different water flow rate cases are examined experimentally, and the obtained response signals are studied. The application of the presented technique is discussed. The results of the tested cases show the feasibility of changing the mass to avoid resonance. The natural frequency shifting is obtained to save the system from high resonance vibration levels that may cause damage to the system.}, file = {https://oru.diva-portal.org/smash/get/diva2:1998714/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_merilineneija_2025, title = {Nature-society relations in disaster governance frameworks}, author = {Meriläinen, Eija}, year = {2025}, journal = {Disasters. The Journal of Disaster Studies, Policy and Management}, volume = {49}, number = {2}, doi = {10.1111/disa.12678}, url = {1942977}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {finland; nordic; disaster governance; nature; nature–society dualism; other‐than‐human nature; periphery; relations}, abstract = {This paper studies how the relations between nature and society are constructed in disaster governance frameworks. Dominant disaster governance frameworks present nature and society as separate realms, and the organisation of society is increasingly seen as the key cause of hazards and disasters. Disaster impacts are similarly framed around adverse societal consequences, while other-than-human nature is merely the background across which disasters unfold, as property lost, or a means of disaster governance. Although the centrality of human impacts is troubled when biodiversity or a disaster flagship species is threatened, neither situation challenges the nature-society dualism embedded in dominant disaster governance frameworks. The attention and resources of disaster governance target the societal side of nature-society dualism. This study finds, though, that in peripheries characterised by remoteness from centres of power, a sparse human population, and large spaces of other-than-human nature, the vulnerabilities facing humans and other-than-human nature risk being ungoverned.}, issn = {0361-3666} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_oljanse_2025, title = {Navigating ethical complexities in health education : exploring challenges in teaching food and health}, author = {Oljans, E. and Quennerstedt, M. and Barker, Dean and Caldeborg, Annica and Varea, V.}, year = {2025}, journal = {Scandinavian Journal of Educational Research}, doi = {10.1080/00313831.2025.2600948}, url = {2028846}, language = {eng}, publisher = {Routledge}, keywords = {food; health education; ethical dilemmas; didactical strategies; immigrant students}, abstract = {Teaching food and health may be challenging, especially in classrooms where young people from different cultures, ethnicities, and religions meet. This article explores teachers' navigation of ethical complexities when teaching food and health in classrooms with immigrant students. Five didactical strategies were identified: (1) The educare strategy, (2) The tiptoeing strategy, (3) The collegial support strategy, (4) The intercultural strategy, and (5) The pluralistic strategy. These didactical strategies are embedded in various educational settings. Our results demonstrate that a further focus on ethical and intercultural competence should be carefully supported and implemented in teacher education and continual professional development programmes for teachers.}, issn = {0031-3831} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lidskogrolf_2025_3, title = {Navigating Global Environmental Challenges : Disciplinarity, Transdisciplinarity, and the Emergence of Mega-Expertise}, author = {Lidskog, Rolf}, year = {2025}, journal = {Climate}, volume = {13}, number = {1}, doi = {10.3390/cli13010020}, url = {1928452}, language = {eng}, publisher = {MDPI}, keywords = {expertise; global environmental assessment (gea); global environmental challenge; ipcc; science–policy interface; science–policy relations; sustainable development goals (sdgs); transdisciplinary; transformative change}, abstract = {This study explores the nature and significance of a crucial form of global environmental expertise: that which relates to conducting global environmental assessments with the aim of influencing decision-making. Drawing on the theory of expertise, which conceptualizes expertise as a social position defined by epistemic practice, this study focuses on expertise in the context of global environmental challenges—particularly relating to climate change and the IPCC—highlighting the expertise required to address this kind of complex and multifaceted issue. This type of expertise allows for a synthesis of the current state of environmental challenges, the proposal of options for action, and communication of these findings to decision-makers and society at large. This expertise shapes knowledge that is much broader than a single disciplinary field, encompassing both ecological and social dynamics, and allows for the development of recommendations for action. This study finds that such expertise embodies a distinct epistemic practice with four key characteristics that distinguish it from more narrowly defined forms of expertise and introduces the term “mega-expertise” to capture the character and position of this kind of expertise. This study concludes by reflecting on the broader implications of this form of expertise, considering its relationship to more traditional, disciplinary scientific expertise.}, file = {https://oru.diva-portal.org/smash/get/diva2:1928452/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_demydyukganna_2025_5, title = {Navigating the Global Worlds : Linking Passenger Experience to Cost–Benefit Decisions}, author = {Demydyuk, Ganna and Tavares, Jean Max and Carlbäck, Mats and Nervo, Nicolas}, year = {2025}, url = {1989572}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_barowthomas_2025, title = {“Needed and Valuable Instead of Just Being Employed” : Vocational Training, Work and Social Usefulness Regarding People with Intellectual Disability in Sweden, 1945–1989}, author = {Barow, Thomas}, year = {2025}, journal = {Nordic Journal of Educational History}, volume = {12}, number = {2}, pages = {63--87}, doi = {10.36368/njedh.v12i2.1314}, url = {2016138}, language = {eng}, publisher = {Department of Historical, Philosophical, and Religious Studies, Umeå University}, keywords = {ableism; disability history; employment; intellectual disability; sweden}, abstract = {The article explores the transition of Swedish students with intellectual disability (ID) into the labour market between 1945 and 1989, a period often overlooked in historical studies on special education and disability research. It analyses the concept of employability in the history of education for this marginalised group, shedding light on the justification for vocational education and on the significance of economic shifts, follow-up studies, and sheltered workshops. Drawing on ableism and pedagogical theory, it underscores qualification, socialisation and subjectification as key educational domains. Utilising professional literature and policy documents, the article suggests a broader understanding of employment creation, considering changes in the labour market and care services. From an ableist perspective, the emphasis on employability leads to a paradox. Due to the overvaluation of functionality and capability, inclusion in work life may result in reduced recognition for those who deviate from the norm.}, issn = {2001-7766}, file = {https://oru.diva-portal.org/smash/get/diva2:2016138/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lihansen_2025_1, title = {Neighborhood social contact and cohesion mediate the relationship between subjectively perceived artificial light at night and mental wellbeing}, author = {Li, Hansen and Yang, Ying and Liu, Qian and Zhang, Xing and Yin, Mingyue and Zhang, Guodong and Cao, Yang}, year = {2025}, journal = {Journal of Health Psychology}, volume = {30}, number = {11}, pages = {3108--3124}, doi = {10.1177/13591053241307366}, url = {1929398}, language = {eng}, publisher = {Sage Publications}, keywords = {health; illumination; nocturnal activity; recreation; social interaction}, abstract = {Artificial Light at Night (ALAN) may improve health by promoting increased social activity. However, this hypothesis still lacks empirical evidence. In this study, we conducted an online survey to investigate the relationship between both subjective and objective measures of artificial light at night (ALAN) and mental wellbeing among 646 adults across 27 provinces in China. Additionally, we explored the potential mediating role of social contact and social cohesion within neighborhoods. Objective ALAN data were obtained through remote sensing technologies, while subjective ALAN exposure, social contact, and social cohesion were assessed via pre-established survey instruments. We found a non-linear relationship between subjective ALAN and mental wellbeing: subjective ALAN scores within the range of 6-11 (out of a total of 11) were positively correlated with mental wellbeing. This association was largely explained by neighborhood social contact and social cohesion, particularly among men. These results underscore the bright side of ALAN and provide a mechanism for understanding the health benefits of ALAN.}, issn = {1359-1053} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_buenomariana_2025, title = {Neonatal and infant pain assessment}, author = {Bueno, Mariana and Eriksson, Mats and Stevens, Bonnie J.}, year = {2025}, pages = {375--390}, doi = {10.1093/med/9780198818762.003.0036_update_001}, url = {2034763}, language = {eng}, publisher = {Oxford University Press}, keywords = {pain; pain assessment; neonate; infant; measures; neonatal; knowledge translation (kt)}, abstract = {Pain assessment is an essential foundation to mitigate pain and its consequences in the developing child. However, pain assessment in neonates and infants is challenging and, to date, there is no “gold standard” infant pain indicator, measure, or approach. This chapter encompasses (1) an overview of indicators of neonatal/infant pain; (2) a comprehensive evaluation of the most current and well-validated neonatal/infant pain assessment measures; (3) the integration of recommendations on pain assessment measures and practices within clinical practice guidelines, policies, and procedures; and (4) challenges associated with neonatal and infant pain assessment in terms of research, clinical, and knowledge translation issues.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_henreksonmagnus_2025, title = {Neo-Schumpeterian growth theory : missing entrepreneurs results in incomplete policy advice}, author = {Henrekson, Magnus and Johansson, Dan}, year = {2025}, journal = {Small Business Economics}, volume = {65}, number = {1}, pages = {407--425}, doi = {10.1007/s11187-024-00994-0}, url = {1936027}, language = {eng}, publisher = {Springer}, keywords = {creative destruction; economic growth; entrepreneur; entrepreneurship policy; innovation; judgment; knightian uncertainty; b40; o10; o30}, abstract = {The neo-Schumpeterian growth models, which appeared in the early 1990s, have ostensibly reintroduced the entrepreneur into mainstream growth theory. However, we show that by ignoring genuine uncertainty and by assuming that profits follow an objectively true and ex ante known probability distribution, the entrepreneur is made redundant. Thus, the theory fails to exhaustively explain innovation, the role of ownership competence, profits, the function of financial markets, wealth and income distribution, and, ultimately, economic growth. These shortcomings risk leading to erroneous or overly narrow policy conclusions by overestimating the importance of supporting R&D investments. Rather, the presence of genuine uncertainty forms a fundamental theoretical basis for the importance of new venture creation as a source of innovation-driven growth; entrepreneurs must establish and expand firms to capture the subjectively perceived profit opportunities. Therefore, tax policy is decisive for the commercialization and dissemination of innovations by providing incentives to uncertainty-bearing, not only for entrepreneurs, but also for intrapreneurs and financiers taking an active part in the governance and development of firms based on innovations characterized by genuine uncertainty. Furthermore, taxation can distort the evolutionary selection of innovations and firms, for instance, by taxing owners and firms differently.}, issn = {0921-898X} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_manginasn_2025, title = {NeSyA : Neurosymbolic Automata}, author = {Manginas, N. and Paliouras, G. and De Raedt, Luc}, year = {2025}, pages = {5950--5958}, doi = {10.24963/ijcai.2025/662}, url = {2028720}, language = {eng}, publisher = {International Joint Conferences on Artificial Intelligence}, abstract = {Neurosymbolic (NeSy) AI has emerged as a promising direction to integrate neural and symbolic reasoning. Unfortunately, little effort has been given to developing NeSy systems tailored to sequential/temporal problems. We identify symbolic automata (which combine the power of automata for temporal reasoning with that of propositional logic for static reasoning) as a suitable formalism for expressing knowledge in temporal domains. Focusing on the task of sequence classification and tagging we show that symbolic automata can be integrated with neural-based perception, under probabilistic semantics towards an end-to-end differentiable model. Our proposed hybrid model, termed NESYA (Neuro Symbolic Automata) is shown to either scale or perform more accurately than previous NeSy systems in a synthetic benchmark and to provide benefits in terms of generalization compared to purely neural systems in a real-world event recognition task. Code is available at: https://github.com/nmanginas/nesya.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_sdergrenjonatan_2025_2, title = {Netnography to Study People with Disabilities : An Interview with Robert V. Kozinets}, author = {Södergren, Jonatan and Vallström, Niklas}, year = {2025}, doi = {10.4324/9781032691664-11}, url = {1958145}, language = {eng}, publisher = {Routledge}, abstract = {This chapter examines the use of netnography to explore the digital lives of people with disabilities. As traditional research methods often fall short in capturing the complexity of online interactions, netnography offers a nuanced approach to understanding how digital platforms, for example, facilitate community building, coping strategies, and advocacy. Drawing on insights from netnography pioneer Kozinets, this chapter demonstrates how this methodology amplifies marginalised voices, addresses stigma, and uncovers hidden dynamics within disability communities. Ethical considerations, including data privacy and informed consent, are also discussed to ensure responsible and sensitive research practices. Netnography emerges as an indispensable tool for disability research, offering cultural insights and promoting inclusivity in an increasingly digital world. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_haschenina_2025_1, title = {Network change in circular economy transitions : examining interconnectedness, embeddedness and adaptations as key constructs}, author = {Hasche, Nina and Keränen, Outi and Ojansivu, Ilkka and Ulkuniemi, Pauliina and Vellesalu, Ann}, year = {2025}, journal = {Journal of Organizational Change Management}, volume = {38}, number = {5}, pages = {1023--1039}, doi = {10.1108/JOCM-02-2025-0175}, url = {1995048}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {circular economy; behaviors; network change; industrial marketing and purchasing; interconnectedness; embeddedness; adaptations}, abstract = {Purpose: Literature is abundant in identifying challenges related to multi-actor and cross-sector collaboration needed in circular economy transitions. This conceptual paper applies theoretical perspectives from the Industrial Marketing and Purchasing literature (IMP) to better understand these challenges and the underlying mechanisms of network change. Specifically, we examine the theoretical constructs of adaptations, interconnectedness, and embeddedness to provide insights into network change in the circular economy transition. This approach thus takes the behavioral instead of technical approach to CE.Design/methodology/approach: The paper is a conceptual study in which existing literature on CE is enriched by employing knowledge from the literature on business relationships and industrial networks. The present study seeks to develop a model by using the IMP theories as method theories to increase understanding of CE transitions.Findings: We develop a set of fundamental premises that reconcile the gaps in the CE literature and provide guidance for facilitating network change in CE transitions. Finally, we develop a theoretical model of network change in CE transitions, including solutions to address the identified challenges.Originality/value: The findings of the present study offer a contribution to the existing literature on CE transition, especially the theoretical discussion related to CE challenges. The paper conceptually advances the literature on CE transition by proposing three premises depicting the network change mechanisms toward CE.}, issn = {0953-4814} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_grimespoppyz_2025, title = {Network temperature as a metric of stability in depression symptoms across adolescence}, author = {Grimes, Poppy Z. and Murray, Aja L. and Smith, Keith and Allegrini, Andrea G. and Piazza, Giulia G. and Larsson, Henrik and Epskamp, Sacha and Whalley, Heather C. and Kwong, Alex S. F.}, year = {2025}, journal = {Nature Mental Health}, volume = {3}, number = {5}, pages = {548--557}, doi = {10.1038/s44220-025-00415-5}, url = {1958442}, language = {eng}, publisher = {Nature Publishing Group}, keywords = {depression}, abstract = {Depression is characterized by diverse symptom combinations that can be represented as dynamic networks. While previous research has focused on central symptoms for targeted interventions, less attention has been given to whole-network properties. Here we show that 'network temperature', a novel measure of psychological network stability, captures symptom alignment across adolescence-a critical period for depression onset. Network temperature reflects system stability, with higher values indicating less symptom alignment and greater variability. In three large longitudinal adolescent cohorts (total N = 35,901), we found that network temperature decreases across adolescence, with the steepest decline during early adolescence, particularly in males. This suggests that depression symptom networks stabilize throughout development via increased symptom alignment, potentially explaining why adolescence is a crucial period for depression onset. These findings highlight early adolescence as a key intervention window and underscore the importance of sex-specific and personalized interventions.} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_ebersmartin_2025_2, title = {Neue europäische Produkthaftung : Update oder Upgrade der Haftung für innovative Technologien?}, author = {Ebers, Martin and Gsell, Beate and Mayrhofer, Ann-Kristin and Danda, Clemens}, year = {2025}, doi = {10.5771/9783748949138}, url = {2024559}, language = {ger}, publisher = {Nomos Verlagsgesellschaft}, abstract = {This compilation examines the new EU Product Liability Directive and its impact on European legal systems. The study of the effects in Germany, Austria, France, Spain and Switzerland is accompanied by practical analyses in the areas of medical devices, automated driving and insurance. The focus is on the question of how the new directive will change product liability for innovative technologies: Will it merely update the liability rules, or will product liability be fundamentally expanded through new functionalities (upgrade)?}, file = {https://oru.diva-portal.org/smash/get/diva2:2024559/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_chenjin_2025, title = {Neural–genetic–environmental evidence for a disease factor in mental and physical health multimorbidity}, author = {Chen, Jin and Zhang, Yuning and Liu, Shu and Garcia-Argibay, Miguel and Jia, Tianye and Kang, Jujiao and Li, Wei and Solmi, Marco and Sun, Hongyi and Liu, Wenqi and Chu, Congying and Cortese, Samuele and Wang, Jiaojian}, year = {2025}, journal = {Nature Communications}, volume = {16}, number = {1}, doi = {10.1038/s41467-025-65055-w}, url = {2014663}, language = {eng}, publisher = {Springer Nature}, abstract = {Increasing evidence reveals the presence of multimorbidity across physical and mental disorders. A general disease factor (d factor) has been recently identified to capture the shared liability across these conditions, yet its biological basis remains poorly understood. Here, using data from the UK Biobank, we reveal the d factor’s neural, genetic, and environmental underpinnings. We show that the d factor is associated with extreme negative deviations in grey matter volume and white matter microstructure. A genome-wide association study identifies its genetic loci and correlations with unhealthy lifestyle, anthropometric measures, and mood-related phenotypes. Furthermore, Mendelian randomization suggests a causal effect of living environmental deprivation on the d factor. Mediation analysis further reveals that the d factor links this environmental adversity to individual differences in brain structure. Our findings establish a multi-level biological characterization of general disease liability, connecting environmental, genetic, and neural factors and inform transdiagnostic approaches to prevention and treatment.}, file = {https://oru.diva-portal.org/smash/get/diva2:2014663/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nyholmermanda_2025, title = {Neurodevelopmental and psychiatric conditions in 600 Swedish children with the avoidant/restrictive food intake disorder phenotype}, author = {Nyholmer, Manda and Wronski, Marie-Louis and Hog, Liv and Kuja-Halkola, Ralf and Lichtenstein, Paul and Lundström, Sebastian and Larsson, Henrik and Taylor, Mark J. and Bulik, Cynthia M. and Dinkler, Lisa}, year = {2025}, journal = {Journal of Child Psychology and Psychiatry}, volume = {66}, number = {9}, pages = {1333--1344}, doi = {10.1111/jcpp.14134}, url = {1944254}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {comorbidity; anxiety; autism; eating disorders; food fussiness; mental health}, abstract = {BACKGROUND: Avoidant restrictive food intake disorder (ARFID) is a feeding and eating disorder characterized by extremely restricted dietary variety and/or quantity resulting in serious consequences for physical health and psychosocial functioning. ARFID often co-occurs with neurodevelopmental conditions (NDCs) and psychiatric conditions, but previous data are mostly limited to small clinical samples examining a narrow range of conditions. Here, we examined NDCs and psychiatric conditions in a large, population-based group of children with ARFID.METHODS: In 30,795 children born 1992-2008 in Sweden, ARFID was assessed using parent reports and clinical diagnoses from national health registers. Parents further reported symptoms of NDCs and psychiatric conditions at child age 9 or 12 years. Validated cutoffs were applied to the resulting symptoms scores to identify above-threshold conditions. We then examined whether ARFID was associated with higher symptom scores (19 outcomes) and higher likelihood of above-threshold conditions (15 outcomes) using linear and logistic regressions.RESULTS: Most prevalent in children with ARFID were separation anxiety (29.0%), oppositional defiant disorder (19.4%), attention deficit hyperactivity disorder (ADHD, 16.9%), panic disorder (15.3%), and tic disorders (14.8%). For all measured co-occurring conditions, ARFID was associated with significantly higher symptom scores (standardized beta range: 0.6-1.5) and higher odds of above-threshold conditions (odds ratio [OR] range: 3.3-13.7). The conditions with the highest increase in odds were autism (OR = 13.7) and ADHD (OR = 9.4). We did not find any sex-specific differences in co-occurring conditions.CONCLUSIONS: This study highlights the co-occurrence of a broad range of NDCs and psychiatric conditions with ARFID in a large, non-clinical cohort. Our findings underscore that children with ARFID face significant burden from multiple co-existing conditions which should be considered during assessment and treatment.}, issn = {0021-9630} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_wedinmaria_2025_1, title = {Neuroendocrine tumors : biomarkers and functional imaging for clinical assessment}, author = {Wedin, Maria}, year = {2025}, url = {1919994}, language = {eng}, publisher = {Örebro University}, abstract = {In Sweden, approximately 400-500 individuals are diagnosed yearly with a neuroendocrine tumor (NET). Primary tumors can arise from all organs in the body, but most commonly from the gastrointestinal (GI) tract (75%) or the lungs (20%). The small intestine (Si) is the most common primary site (35%). The tumor is often diagnosed when metastatic disease has already developed (85% of cases), and spreading is mostly located in the abdominal lymph nodes or liver. Extra-abdominal metastases may also occur. Unlike other tumors, patients with NET and metastatic disease survive for many years. The tumor is diagnosed through a combination of disease-specific biomarkers, radiology and histopathological examination from a biopsy or surgical specimen. 68Ga-DOTATOC-positron emission tomography (PET) and concomitant diagnostic computed tomography (CT) have frequently been used in recent years, due to the high specificity and sensitivity for NET cells.The aim of this thesis was to evaluate the clinical utility of a commonly used biomarker in patient serum, and to assess the prevalence and importance of metastases to abdominal lymph nodes and extra-abdominal distant metastatic sites with a specific interest in Si-NET and pancreatic NET (pan-NET). Finally, the prognostic impact of disease burden from bone metastases in patients with Si-NET has also been studied.The first study included one of the most used biomarkers in NET disease and the association between changes in serum 5-HIAA and tumor burden on CT/MRI scan. We also validated the clinical utility of 5-HIAA analysis in patient serum compared to traditional urinary measurement establishing the use of serum analysis at Örebro University Hospital, being less time-consuming and more convenient for patients. In the second study, we assessed the prognostic role of risk factors in patients with locoregional Si-NET, with a specific interest in recurrent disease, and also aimed to define a surgical cut-off for harvested mesenteric lymph nodes to accurately stage these tumors. A minimum of five harvested mesenteric lymph nodes appears to be critical in surgical management. In the third study, we further studied the prevalence of extra-abdominal metastases evident on 68Ga-DOTATOC-PET/CT. The study concluded that metastases to the bones, left supraclavicular lymph nodes, heart, orbit and breast and, in patients with Si-NET, to the pancreas probably occurred more frequently than previously described. Patients with Si-NET harboured extra-abdominal metastases both more frequently and in different locations compared to patients with pan-NET. In the fourth study, we evaluated the prognostic role and clinical symptoms of bone metastases (BM) in patients with Si-NET. In conclusion, the presence of BM, higher extent of BM (>5BM) and synchronous BM at NET diagnosis were independent negative prognostic factors of survival.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_hazrarishi_2025_2, title = {Neurosymbolic Decision-Making with Large Language Models}, author = {Hazra, Rishi}, year = {2025}, url = {1985111}, language = {eng}, publisher = {Örebro University}, abstract = {Reasoning and decision-making are foundational challenges in artificial intelligence (AI). These processes are closely linked – an intelligent agent must reason about its environment and goals in order to make decisions and select actions. Two principal frameworks for sequential decision-making are AI planning and reinforcement learning (RL). Planning assumes access to a known model of the environment and uses symbolic representations to compute a sequence of actions that leads from an initial state to a desired goal. In contrast, RL focuse son learning behavior through interaction, enabling agents to develop policies that maximize long-term reward under uncertainty. Despite methodological differences, both approaches aim to generate intelligent, goal-directed action sequences.The rise of Large Language Models (LLMs) has sparked significant interest in their potential to perform reasoning, planning, and decision-making tasks. Despite their impressive performance in natural language understanding and generalization, there is growing skepticism about whether LLMs genuinely reason or merely leverage statistical correlations. This dissertation investigates this question through a principled evaluation grounded in computational theory, using 3-SAT – the canonical NP-complete problem – as a testbed. The findings demonstrate that LLMs fail to exhibit sound and complete reasoning, especially on complex instances where shallow heuristics fail, and that their apparent reasoning abilities often stem from overfitting to statistical patterns.To address these limitations, this dissertation proposes a range of neurosymbolic architectures that combine the generative flexibility of LLMs with the rigor and reliability of symbolic methods. Empirical evaluations across planning, reward design, and plan verification tasks show that such integration yields systems that are more robust and accurate. This work advances our theoretical and practical understanding of LLM-based reasoning, provides concrete design principles for neurosymbolic systems, and charts a path toward AI agents that integrate world knowledge with logical precision.}, file = {https://oru.diva-portal.org/smash/get/diva2:1985111/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_debotdavid_2025, title = {Neurosymbolic Reinforcement Learning : Playing MiniHack With Probabilistic Logic Shields}, author = {Debot, David and Venturato, Gabriele and Marra, Giuseppe and De Raedt, Luc}, year = {2025}, pages = {29631--29633}, doi = {10.1609/aaai.v39i28.35349}, url = {1986640}, language = {eng}, publisher = {AAAI Press}, abstract = {Probabilistic logic shields integrate deep reinforcement learning (RL) with probabilistic logic reasoning to train agents that operate in uncertain environments while giving strong guarantees with respect to logical constraints, such as safety properties. In this demo paper, we introduce a codebase that streamlines the design of custom MiniHack environments where neurosymbolic RL agents leverage probabilistic logic shields to learn safe and interpretable policies with strong guarantees. Our framework allows expert users to easily define and train agents that integrate deep neural policies with probabilistic logic in arbitrarily complex games: from simple exploration to planning and interacting with enemies. Additionally, we provide a web-based platform that showcases our application, offering an interactive interface for the broader community to experiment with and explore the capabilities of neurosymbolic reinforcement learning. This lowers the barrier for researchers and developers, making it accessible for a wider audience to engage with safety-critical RL scenarios.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dorofteluiza_2025, title = {New histological risk grading system for prediction of lymph node metastasis in patients with penile cancer}, author = {Dorofte, Luiza and Davidsson, Sabina and Carlsson, Jessica and Lillsunde-Larsson, Gabriella and Karlsson, Mats}, year = {2025}, journal = {Virchows Archiv}, volume = {486}, number = {4}, pages = {759--767}, doi = {10.1007/s00428-024-03916-3}, url = {1896369}, language = {eng}, publisher = {Springer}, keywords = {histological risk grading; lymph node metastasis; penile cancer; risk groups}, abstract = {Inguinal lymph node surgery is a standard treatment for penile cancer patients with intermediate or high risk for lymph node metastasis (LNM) according to European Association of Urology (EAU) risk grading. We are proposing a more objective histological prognostic grading system for inguinal LNM in these patients. We assessed worst pattern of invasion, lymphocytic host response, lymphovascular invasion, and perineural invasion in a population-based cohort of 306 penile cancer patients. Patients were classified into low, intermediate, and high risk for inguinal LNM. There was a significant association both between risk groups and pT stage (p < 0.001) and between risk groups and LNM. Univariate logistic regression showed 25.43 times higher odds of LNM for patients in the intermediate risk group compared with the low risk group (odds ratio (OR) 25.43; 95% confidence interval (CI): 5.94-108.97) and a 177.13 times higher odds in the high risk group compared to the low risk group (OR 177.13; 95% CI: 40.09-782.51). When comparing our histological risk grading with the EAU grading, we found a higher sensitivity, of 51.28% (95% CI: 45.68-56.88) versus 37.09% (95% CI: 31.68-42.50), as well as a higher area under the curve (0.86; 95% CI: 0.81-0.89; versus 0.65; 95% CI: 0.58-0.71) with our grading system. While our grading classified 111 patients as low risk, only 31 were considered low risk for LNM according to the EAU risk classification. The new histological risk grading system shows a higher sensitivity and includes a higher number of patients in the low risk group in whom lymph node surgery could be avoided, reducing morbidity and costs.}, issn = {0945-6317} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisioannis_2025_7, title = {New IgG and IgA autoantibody specificities against DNA-binding and RNA-binding proteins discriminate systemic lupus erythematosus from health and non-lupus autoimmunity-could anti-LIN28A enhance precision in diagnostics?}, author = {Parodis, Ioannis and Lagutkin, Denis and Lindblom, Julius and Idborg, Helena and Beretta, Lorenzo and Borghi, Maria Orietta and Peyper, Janique M. and Barturen, Guillermo and Jakobsson, Per-Johan and Alarcón-Riquelme, Marta E. and Sherina, Natalia and Nikolopoulos, Dionysis}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {84}, number = {7}, pages = {1180--1194}, doi = {10.1016/j.ard.2025.04.003}, url = {1959137}, language = {eng}, publisher = {Highwire Press}, abstract = {OBJECTIVES: In response to the urgent unmet needs of heterogeneity, unpredictability, and diagnostic delay in systemic lupus erythematosus (SLE), we aimed to identify and validate new immunoglobulin (Ig)G and IgA autoantibody specificities.METHODS: Using a KoRectly EXpressed technology-based microarrays (i-Ome Discovery; Sengenics), we screened for circulating IgG and IgA autoantibodies against 1609 proteins in 2 independent cohorts (discovery: NTC02890121; validation: NCT02890134) comprising patients with SLE (n = 199 and n = 30), primary Sjögren's disease (n = 115 and n = 31), and systemic sclerosis (n = 115 and n = 24), and healthy controls (HCs; n = 111 and n = 84), respectively.RESULTS: We identified and validated 5 IgG (anti-Lin-28 homolog A [LIN28A], anti-HNRNPA2B1, anti-HMG20B, anti-HMGB2, and anti-alpha-globin transcription factor CP2 [TFCP2]) and 4 IgA (anti-LIN28A, anti-HMG20B, anti-SUB1, and anti-TFCP2) autoantibodies that demonstrated high specificity for SLE (0.91-0.94), along with consistent and robust positivity (0.22-0.69) in differentially abundant autoantibody (daAAb) analysis between SLE and comparator groups. IgG and IgA anti-LIN28A levels varied over a 14-month follow-up in the validation cohort of newly diagnosed patients with SLE and exhibited metrics that outperformed those of traditional autoantibody markers such as anti-double-stranded DNA. Clustering of patients with SLE based on autoantibody positivity (levels above the HC median plus 2 IQRs in the discovery cohort) status revealed 1 subgroup demonstrating seroreactivity against multiple antigens, 3 exhibiting varying reactivity, and 1 showing no reactivity. In pathway analysis, daAAb targets pointed to DNA-binding and RNA-binding and transcription functions.CONCLUSIONS: Novel autoantibodies validated in this study may enhance diagnostics and molecular characterisation in SLE. The prominent IgA seroreactivity implicates important roles of mucosal tissues in SLE autoimmunity, warranting further investigation.}, issn = {0003-4967} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisioannis_2025_8, title = {NEW IGG AND IGA AUTOANTIBODY SPECIFICITIES TARGETING DNA- AND RNA-BINDING PROTEINS DIFFERENTIATE SYSTEMIC LUPUS ERYTHEMATOSUS FROM HEALTHY INDIVIDUALS AND OTHER AUTOIMMUNE DISEASES}, author = {Parodis, Ioannis and Lagutkin, Denis and Lindblom, Julius and Idborg, Helena and Beretta, Lorenzo and Orietta Borghi, Maria and Peyper, Janique M. and Barturen, Guillermo and Jakobsson, Per-Johan and Alarcón-Riquelme, Marta and Sherina, Natalia and Nikolopoulos, Dionysis}, year = {2025}, journal = {Journal of Rheumatology}, volume = {52}, number = {Suppl. 1}, pages = {219--220}, doi = {10.3899/jrheum.2025-0390.PV226}, url = {2014515}, language = {eng}, publisher = {The Journal of Rheumatology}, issn = {0315-162X} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_erteltsophiemarie_2025, title = {Next exit: Net-zero? Transition acceleration challenges in hard-to-abate industries : The case of heavy-duty freight transport}, author = {Ertelt, Sophie-Marie}, year = {2025}, url = {1929734}, language = {eng}, publisher = {Örebro University}, keywords = {net-zero transitions; hard-to-abate industries; heavy-duty road freight; acceleration challenges; transition governance}, abstract = {This thesis investigates net-zero transition acceleration challenges in hard-to-abate industries, focusing on heavy-duty freight transport. It examines how incumbent actors, carbon lock-in, and systemic inertia shape decarbonisation progress, which is less likely to result from Schumpeterian creative destruction and more dependent on the reconfiguration of existing socio-technical systems. This recon-figuration perspective forms the theoretical foundation of the thesis and extends to examine the conditions and mechanisms of endogenous socio-technical change processes.The research integrates organisational studies into transitions research to analyse five acceleration challenges: whole systems change, multi-system dynamics, decline and resistance, shifts in demand patterns, and governance. Empirical insights come from case studies of the European heavy-duty vehicle sector and Swedish electrification and Circular Economy initiatives. Using a multi-method and mixed-method approach, the thesis combines interviews, surveys, and secondary data analysis to examine these challenges for heavy-duty freight transport.This research offers theoretical contributions to better capture system reconfigurations and the role of incumbents in such processes. It also informs the conceptualisation of three additional acceleration challenges and proposes actionable insights for policymakers, including integrated, multi-system governance approaches and sufficiency-oriented decarbonisation planning.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_peterssonmalin_2025, title = {Nicotine, Alcohol Consumption, and Risk of Myasthenia Gravis : Results From the Swedish Nationwide GEMG Study}, author = {Petersson, Malin and Jons, Daniel and Feresiadou, Amalia and Ilinca, Andreea and Lundin, Fredrik and Johansson, Rune and Budzianowska, Anna and Roos, Anna-Karin and Kagstrom, Viktor and Gunnarsson, Martin and Sundström, Peter and Klareskog, Lars and Olsson, Tomas and Kockum, Ingrid and Piehl, Fredrik and Alfredsson, Lars and Brauner, Susanna}, year = {2025}, journal = {Neurology}, volume = {105}, number = {1}, doi = {10.1212/WNL.0000000000213771}, url = {1967975}, language = {eng}, publisher = {Wolters Kluwer}, abstract = {BACKGROUND AND OBJECTIVES: Myasthenia gravis (MG), an autoimmune disease characterized by fluctuating muscle weakness, is believed to result from complex gene-environment interactions, yet few risk factors have been identified. The objective of this study was to determine the effect of nicotine and alcohol on MG disease risk.METHODS: The Genes and Environment in Myasthenia Gravis study is a Swedish, nationwide cross-sectional case-control study where prevalent patients with MG were invited to submit an extensive questionnaire on lifestyle and environment. Data collection took place between November 2018 and August 2019, and cases were matched by sex and year of birth to population controls. Year of disease onset was used as index year. Associations between use of alcohol, tobacco smoke, Swedish snuff, and MG risk were investigated using multivariable logistic regression.RESULTS: A total of 1,067 patients with MG (mean age at onset 48 (SD 21) years, 53% female) were matched to 2,087 controls. Any alcohol consumption was associated with a lower MG risk compared with not drinking at all (odds ratio [OR] 0.48, 95% CI 0.39-0.59, p < 0.001, exposed cases n = 616). Effects were observed in a similar direction across disease subtypes, with the strongest association in the late-onset MG group (onset ≥50 years). Although neither cigarette smoke nor use of Swedish snuff affected the disease risk of the whole group, subset specific effects were observed. Smoking at onset was associated with an increased risk of early-onset MG (EOMG, onset 18-49 years; OR 1.60, 95% CI 1.17-2.20, p = 0.003, n = 133), which was accentuated in acetylcholine receptor antibody-positive EOMG (OR 2.08, 95% CI 1.34-3.25, p = 0.001, n = 74). Use of Swedish snuff, which contains high levels of nicotine, at disease onset was also associated with an increased risk of EOMG (OR 1.61, 95% CI 1.02-2.54, p = 0.039, n = 43).DISCUSSION: We observed an inverse correlation of MG risk and alcohol consumption. Furthermore, smoking and the use of Swedish snuff at disease onset were positively associated with EOMG. We recognize limitations related to retrospective data and limited number of available controls. However, multiple sensitivity analyses were performed supporting the robustness of our results.}, issn = {0028-3878} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ahlrothpindcaroline_2025, title = {No Improvement of Asthma Control Despite Changes in Pharmacological Treatment Patterns : 17 Years Follow Up}, author = {Ahlroth Pind, Caroline and Ställberg, Björn and Lisspers, Karin and Sundh, Josefin and Kisiel, Marta A. and Sandelowsky, Hanna and Nager, Anna and Hasselgren, Mikael and Montgomery, Scott and Giezeman, Maaike and Eliason, Gabriella and Janson, Christer}, year = {2025}, journal = {Journal of Asthma and Allergy}, volume = {18}, pages = {1825--1834}, doi = {10.2147/JAA.S548231}, url = {2024483}, language = {eng}, publisher = {Dove Medical Press}, keywords = {inhaled corticosteroids; short-acting β2-agonist; written action plan}, abstract = {PURPOSE: Asthma control is reported to be low, often based on cross-sectional studies. There have been only a few longitudinal studies following asthma patients. We have assessed asthma control and asthma treatment over 17 years in a cohort of asthma patients.METHODS: Patients, 18-75 years, with doctor-diagnosed asthma were randomly selected from healthcare units in Sweden. They answered questionnaires about symptoms and pharmacological treatment in 2005, 2012, and 2022. This study includes participants completing the last follow-up (n=437). Optimal asthma control was defined as no nocturnal asthma symptoms, use of short-acting β2-agonist twice or less in the past week, and no exacerbations in the last six months.RESULTS: There was no difference in frequency of optimal asthma control (41.8% vs 40.5%, p=0.68). Inhaled corticosteroids (ICS) in combination with long-acting β2-agonists increased from 2005 to 2022 as regular maintenance treatment (40.3% vs 46.7%, p=0.009) and as reliever medicine (11.6% vs 18.9%, p<0.001). The overall use of reliever medicine more than twice in the past week did not change (48.3% vs 51.6%, p=0.24). The overall use of ICS decreased (78.0% vs 70.4%, p<0.001), as did the occurrence of having a written action plan (21.9% vs 10.4%, p<0.001). Optimal asthma control and lack of written action plans were related to discontinuation of ICS treatment.CONCLUSION: Non-optimal asthma control is common long after diagnosis. Discontinuation of ICS may sometimes be due to optimal asthma control and no need for treatment, but lack of written action plans increases the risk of inappropriate discontinuation.}, issn = {1178-6965} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jossenjacqueline_2025, title = {No Increased Risk of Hepatitis B Virus Infection in Patients with Celiac Disease : A Population-Based Study}, author = {Jossen, Jacqueline and Lebwohl, Benjamin and Söderling, Jonas and Duberg, Ann-Sofi and Aleman, Soo and Sharma, Rajani and Hagström, Hannes and Green, Peter H. R. and Ludvigsson, Jonas F.}, year = {2025}, journal = {Digestive Diseases and Sciences}, volume = {70}, number = {4}, pages = {1521--1529}, doi = {10.1007/s10620-025-08878-3}, url = {1939653}, language = {eng}, publisher = {Springer-Verlag New York}, keywords = {sweden; celiac; coeliac; cohort; gluten; hepatitis b virus; liver disease}, abstract = {OBJECTIVES: Celiac disease (CeD) has been associated with a low response to hepatitis B (HBV) vaccination, but guidelines for testing and revaccination among individuals with CeD are sparse. We examined the risk of future HBV among individuals with CeD in a population-based Swedish cohort. Furthermore, we examined the rate of prior HBV infection in CeD patients.METHODS: All individuals in Sweden diagnosed with biopsy-verified CeD between 1990 and 2017 were identified through the ESPRESSO cohort. Each individual with CeD was matched by age, sex, calendar year, and birth country (Nordic vs. other) with up to 5 reference individuals.RESULTS: We identified 44,721 CeD and 222,238 reference individuals. The incidence rates of diagnosed HBV were 2.3 and 2.9 per 100,000 person-years, respectively. This represented no association with CeD (HR 0.77 (0.45-1.30)). This null association was similar for those with a Nordic (HR 0.80 (0.40-1.60)) and non-Nordic ((HR 0.31 (0.09-1.08)) country of birth. Rates of prior HBV infection were low (CeD 0.08%, controls 0.06%). This corresponded to a small but insignificant increase among individuals with CeD (odds ratio, OR 1.41 (0.97-2.05).CONCLUSION: In a population-based Swedish cohort, there was no increased risk of developing HBV in individuals with CeD. This finding does not support current practices of testing and revaccination for HBV. Additional studies should be completed in areas with higher endemic rates of HBV. Slightly higher rates of prior HBV infection in CeD may be secondary to increased testing in those seeking medical care for another disease process.}, issn = {0163-2116} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_peterssonannah_2025, title = {No need for subacromial decompression in responders to specific exercise treatment : a 10-year follow-up of a randomized controlled trial}, author = {Petersson, Anna H. and Hallgren, Hanna C. Björnsson and Adolfsson, Lars E. and Holmgren, Theresa M.}, year = {2025}, journal = {Journal of shoulder and elbow surgery}, volume = {34}, number = {6}, pages = {e477--e487}, doi = {10.1016/j.jse.2024.10.027}, url = {1963440}, language = {eng}, publisher = {Elsevier}, keywords = {subacromial pain; arthroscopic subacromial decompression; shoulder; long-term; nonoperative treatment}, abstract = {Background: Subacromial pain is a common and disabling condition with multifactorial etiology. Increasing evidence supports exercises as first-line treatment and need of surgery is debated. Long-term follow-ups after surgical-and nonsurgical treatment are scarce. The primary aim of the present study was to investigate the 10-year outcomes after a study comparing specific and nonspecific exercise treatment and the need for surgery. Secondarily we compared patients who had undergone exercise treatment, to those having surgery and explored the importance of rotator cuff status in relation to given treatment and outcomes.Methods: At enrollment 2009-2010, 97 patients with long-standing subacromial pain were on the waiting list for arthroscopic subacromial decompression (ASD). They were randomized to specific exercises focusing on strengthening of the rotator cuff and scapula stabilizers (n = 51) or control: unloaded range of motion exercises (n = 46). ASD was optional during the entire observation time. Eligible patients from either group constitute the present 10-year cohort with nonoperated (n = 42) or operated (n = 41) patients. The primary outcome was shoulder function and pain after 10 years assessed by the Constant-Murley score (CMS). Secondary outcomes were proportion of patients choosing surgery and rotator cuff status related to treatment and primary outcome.Results: At the 10-year follow-up, 83 of 97 patients (86%) participated. All patients significantly improved in CMS from baseline to 10-year follow-up, mean improvement of 37 (95% confidence interval 33-41, P <.0001). Nonoperated patients had significantly better CMS compared to operated with mean difference 11(95% confidence interval 4-18) (P = .003). Significantly more patients in the control exercise group 65% (26 of 40) had chosen surgery compared to 35% (15 of 43) in the specific exercise group up until 10 years (P = .006). At 10 years, 55% of the patients had a partial or full-thickness rotator cuff tear compared to 28% at baseline. There was no difference in tear progression between operated and nonoperated patients (P = .494). In the contralateral shoulder, 51% of the patients (39 of 76) had a cuff tear compared to 3% at baseline.Conclusions: Specific exercise treatment for patients with subacromial pain was effective and reduced the need for surgery with maintained results after 10 years. Responders to exercise treatment had the best long-term outcomes and ASD yielded satisfying outcome in nonresponders. A rotator cuff tear was equally common in patients having undergone surgery as in those treated nonoperatively and in the contralateral shoulder.}, issn = {1058-2746} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_cardiasramon_2025, title = {Noncollinear Edge Magnetism in Nanoribbons of Fe3GeTe2 and Fe3GaTe2}, author = {Cardias, Ramon and Bergman, Anders and Strand, Hugo U. R. and Muniz, R. B. and Costa, Marcio}, year = {2025}, journal = {Nano Letters}, volume = {25}, number = {31}, pages = {11797--11802}, doi = {10.1021/acs.nanolett.5c01890}, url = {1988551}, language = {eng}, publisher = {American Chemical Society (ACS)}, keywords = {magnetism; field-free switching; 2d materials; spin dynamics; spin orbit torque; spintronics}, abstract = {Fe3GeTe2 and Fe3GaTe2 are ferromagnetic conducting materials of van der Waals type with unique magnetic properties that are highly promising for the development of new spintronic, orbitronic, and magnonic devices. Even in the form of two-dimensional-like ultrathin films, they exhibit a relatively high Curie temperature, magnetic anisotropy perpendicular to the atomic planes, and multiple types of Hall effects. We explore nanoribbons made from single layers of these materials and show that they display noncollinear magnetic ordering at their edges. This magnetic inhomogeneity allows angular momentum currents to generate magnetic torques at the sample edges, regardless of their polarization direction, significantly enhancing the effectiveness of magnetization manipulation in these systems. We also demonstrate that it is possible to rapidly reverse the magnetization direction of these nanostructures by means of spin-orbit and spin-transfer torques with rather low current densities, making them quite propitious for nonvolatile magnetic memory units.}, issn = {1530-6984} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_thranepernilleg_2025, title = {Nonculprit Vulnerable Plaques and Prognosis in Myocardial Infarction With Versus Without ST-Segment Elevation : A PROSPECT II Substudy}, author = {Thrane, Pernille G. and Maeng, Michael and Maehara, Akiko and Bøtker, Hans Erik and Mintz, Gary S. and Kjøller-Hansen, Lars and Engstrøm, Thomas and Matsumura, Mitsuaki and Kotinkaduwa, Lak N. and Fröbert, Ole and Persson, Jonas and Wiseth, Rune and Larsen, Alf I. and Jensen, Lisette O. and Nordrehaug, Jan E. and Bleie, Øyvind and Held, Claes and James, Stefan K. and Ali, Ziad A. and Erlinge, David and Stone, Gregg W.}, year = {2025}, journal = {Circulation}, volume = {151}, number = {25}, pages = {1767--1779}, doi = {10.1161/CIRCULATIONAHA.124.071980}, url = {1976536}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, keywords = {st elevation myocardial infarction; coronary artery disease; non-st elevation myocardial infarction; spectroscopy; near-infrared}, abstract = {BACKGROUND: Clinical guidelines recommend different revascularization strategies for nonculprit lesions in patients with ST-segment-elevation myocardial infarction (STEMI) versus non-STEMI (NSTEMI). Whether the prevalence of untreated high-risk vulnerable plaques differs in STEMI and NSTEMI and affects their outcomes is unknown.METHODS: In PROSPECT II (Providing Regional Observations to Study Predictors of Events in the Coronary Tree II), a multicenter, prospective natural history study, patients with recent myocardial infarction underwent 3-vessel coronary angiography with coregistered near-infrared spectroscopy and intravascular ultrasound after successful percutaneous coronary intervention of obstructive lesions from 2014 through 2017. Two-feature high-risk plaques were defined as those with both plaque burden ≥70% and maximum lipid core burden index over any 4-mm segment ≥324.7. The primary end point was major adverse cardiovascular events arising from untreated nonculprit lesions during a median 3.7-year follow-up.RESULTS: Of 898 patients, 199 (22.2%) with 849 nonculprit lesions had STEMI and 699 (77.8%) with 2784 nonculprit lesions had NSTEMI. By intravascular ultrasound, the median nonculprit lesion length was 17.4 mm (interquartile range, 16.3-18.5) in STEMI and 17.7 mm (interquartile range, 17.1-18.4) in NSTEMI (P=0.63), and the median minimal lumen area was 5.5 mm2 (interquartile range, 5.3-5.7 mm2) in STEMI and 5.5 mm2 (interquartile range, 5.3-5.6 mm2) in NSTEMI (P=0.99). At the lesion level, the prevalence of 2-feature high-risk nonobstructive nonculprit plaques was slightly higher in patients with STEMI than in patients with NSTEMI (12.8% versus 10.1%; P=0.03). At the patient level, however, the prevalence of 2-feature high-risk plaques was similar in STEMI versus NSTEMI (38.8% versus 32.7%; P=0.11). The prevalence of patients with 1 or more lesions meeting at least 1 high-risk plaque criterion was also similar (plaque burden ≥70%, 63.3% versus 57.8% [P=0.16]; maximum lipid core burden index over any 4-mm segment ≥324.7, 63.3% versus 57.6% [P=0.15]). The 4-year rates of nonculprit lesion-related major adverse cardiovascular events were similar in STEMI versus NSTEMI (8.6% versus 7.8%; hazard ratio, 1.02 [95% CI, 0.57-1.81]; P=0.95), as were the rates of all major adverse cardiovascular events (14.2% versus 13.0%; hazard ratio, 1.06 [95% CI, 0.68-1.64]; P=0.80).CONCLUSIONS: In the PROSPECT II study, the per-patient prevalence of high-risk vulnerable plaques was comparable in STEMI versus NSTEMI, as was the overall long-term incidence of nonculprit lesion-related and all major adverse cardiovascular events. These results support a similar revascularization strategy for nonculprit lesions in patients with STEMI or NSTEMI after culprit lesion management.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02171065.}, issn = {0009-7322} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_slettvolltove_2025, title = {Non-invasive assessment of free steroid hormones : development of a high-throughput LC-MS/MS method for salivary steroid hormone quantification}, author = {Slettvoll, Tove and Wahlberg, Jeanette and Lood, Yvonne and Josefsson, Martin and Aardal, Elisabeth and Salihovic, Samira}, year = {2025}, journal = {Analytical and Bioanalytical Chemistry}, volume = {417}, number = {21}, pages = {4883--4894}, doi = {10.1007/s00216-025-06005-9}, url = {1986546}, language = {eng}, publisher = {Springer}, keywords = {extraction; free steroid hormones; saliva; lc-ms/ms; unispray ionization}, abstract = {Steroid hormone concentrations reflect diverse physiological and pathological processes and have been recognized as valuable biomarkers for disease, with growing interest in their potential for patient stratification in precision medicine. Salivary steroid concentrations should reflect the free (biologically active) steroids in circulation, as steroids in the bloodstream passively diffuse to saliva. This allows for the direct measurement of free steroids without transporter protein-bound hormones (inactive form). However, implementation of salivary steroid quantification in larger studies remains limited by challenges associated with sample preparation. We began by reviewing the literature on relevant sample preparation approaches and identified commonly used 96-well solid phase extraction (SPE) methods for further evaluation. Three sample preparation methods were selected and assessed in terms of internal standard recovery and matrix effects, and their response was also compared using electrospray (ESI) versus UniSpray ionization (USI) liquid chromatography-tandem mass spectrometry (LC-MS/MS). We demonstrate a sensitive and rapid high-throughput method with Oasis HLB mu Elution SPE of 200 mu L saliva in 96-well format and USI-LC-MS/MS for major steroids (testosterone, androstenedione, cortisone, cortisol, and progesterone) in saliva. The method achieved optimal recovery (77%), matrix effects (33%), and sensitivity with detection limits (MDL) ranging between 1.1 and 3.0 pg/mL and linearity (r2 = 0.99). Intra-plate and inter-plate coefficient of variation (CV) was below 7% and 20% using USI. USI provided a higher (2.0-2.8-fold) response than ESI and higher signal-to-noise ratio (S/N). The method was then applied to 97 authentic saliva samples (41 male and 56 female) and significant correlations between age and BMI, and androgen levels were observed in both sexes. The proposed 96-well SPE USI-LC-MS/MS method is well-suited for determining steroid hormones in saliva with potential usefulness in large-scale studies and clinical settings.}, issn = {1618-2642} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrkjonas_2025_1, title = {Non-pharmaceutical interventions to prevent community transmission of infectious diseases with pandemic potential-an umbrella review and evidence map}, author = {Björk, Jonas and Rasmussen, Gunlög and Johansson, Susanne and Dagerhamn, Jessica and Olofsson, Hanna and Wilbe Ramsay, Karin}, year = {2025}, journal = {European Journal of Public Health}, doi = {10.1093/eurpub/ckaf170}, url = {2004412}, language = {eng}, publisher = {Oxford University Press}, abstract = {During the COVID-19 pandemic, most countries implemented non-pharmaceutical interventions (NPIs) to mitigate virus transmission and decrease morbidity and mortality. The aim of this umbrella review was to identify and map systematic reviews on the effectiveness of NPIs to reduce widespread community transmission of infectious diseases with pandemic potential. We searched electronic databases (Medline, Embase, Scopus, INAHTA [International Network of Agencies for Health Technology Asseesment], and World Health Organization COVID-19) and websites (January 2024). Systematic reviews on NPIs during outbreaks, epidemics, or pandemics of COVID-19, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), influenza, or Ebola were included and organized in an interactive evidence map grouped by type of intervention (individual/population/environmental), disease, risk of bias, and search date. Five of the 132 included reviews were assessed as having low, 43 moderate, and 84 high risk of bias. COVID-19 was targeted in 100 reviews, influenza 66, SARS 39, MERS 34, and Ebola in five reviews. The most frequently investigated NPIs were use of face masks, hand washing, physical distancing, travel restrictions, restrictions on public gatherings, and school closures. The five reviews at low risk of bias concluded at low level of evidence about the effectiveness of most NPIs, with exceptions of hand hygiene and some measures in school settings where low- to moderate-certainty evidence was found. There is substantial lack of evidence regarding the effectiveness of several commonly used NPIs, including restrictions on public gatherings, travel restrictions, and visiting restrictions in long-term care facilities. There is a paucity not only of systematic reviews but also of primary studies at low risk of bias.}, issn = {1101-1262} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tiltonweaverlauree_2025, title = {Non-Suicidal Self-Injury and Depressive Symptoms During Adolescence : Testing Directionality}, author = {Tilton-Weaver, Lauree and Schwartz-Mette, Rebecca}, year = {2025}, journal = {Journal of Youth and Adolescence}, volume = {54}, pages = {2168--2179}, doi = {10.1007/s10964-025-02183-y}, url = {1951772}, language = {eng}, publisher = {Plenum Publishing}, keywords = {adolescence; bidirectional; depressive symptoms; non-suicidal self-injury; transactional}, abstract = {As risk for both non-suicidal self-injury and depression increases at adolescence, it is critically important to clarify equivocal findings regarding the temporal ordering of these health concerns. Addressing the limitations of past research, which included the use of only two data waves and analyses that do not account for within-person variance, the aim in this study was to examine the temporal ordering of non-suicidal self-injury and depressive symptoms during adolescence. Two independent samples were examined. One sample (first used by Marshall et al., 2013) consisted of 799 Swedish adolescents (11 to 15 years, Mage = 13.18, SD = 0.74; 51% girls). The second sample was a later cohort of adolescents from the same area (N = 2760; aged 12 to 18 years, Mage = 13.75, SD = 0.74; 49% girls). Analyses were two-part cross-lagged panel models (CLPMs) and random-intercept cross-lagged panel models (RI-CLPMs) to account for the semi-continuous distribution of NSSI and to determine if traditional lagged models were adequate for estimating within-person temporal ties. The results suggest that traditional CLPMs had inadequate fits to data. RI-CLPMs showed significant within-person, transactional associations between depressive symptoms and NSSI. Specifically, NSSI at a mean age around 13 years was associated with increases in depressive symptoms one year later, which were in turn associated with increases in NSSI when the average age was about 15 years old. Subsequently, lags suggested the potential for maintenance of comorbid distress. These results suggest that efforts to reduce depression and NSSI during adolescence need to begin in early adolescence, with a focus on adaptive responses to distressing emotional experiences.}, issn = {0047-2891} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tislerselina_2025, title = {Nontarget and Suspect Screening of Fluorinated Ionic Liquids and PFAS in European Wastewaters Using Supercritical Fluid Chromatography}, author = {Tisler, Selina and Zweigle, Jonathan and Gotil, Maria Kregler and Finckh, Saskia and Brack, Werner and Braxmaier, Eva-Maria and Meyer, Corina and Hollender, Juliane and Kosjek, Tina and Schymanski, Emma L. and Larsson, Pontus and Kärrman, Anna and Selin, Erica and Elabbadi, Dalia and Elliss, Harry and Kasprzyk-Hordern, Barbara and Boogaerts, Tim and Covaci, Adrian and Oberacher, Herbert and Flores Quintana, Harold and Lai, Foon Yin and Ahrens, Lutz and Assoumani, Azziz and Béen, Frederic and Christensen, Jan H.}, year = {2025}, journal = {Environmental Science and Technology}, volume = {59}, number = {39}, pages = {21300--21311}, doi = {10.1021/acs.est.5c06876}, url = {2001834}, language = {eng}, publisher = {American Chemical Society (ACS)}, keywords = {bis-fasis; fluorine mass balance; hexafluorophosphate; inorganic fluorinated compounds; ultrashort-chain pfas}, abstract = {Per- and polyfluoroalkyl substances (PFAS) and fluorinated ionic liquids were investigated in municipal effluents from 30 wastewater treatment plants (WWTPs) across 15 European countries using supercritical fluid chromatography-high-resolution mass spectrometry (SFC-HRMS) for nontarget screening. Bis-perfluoroalkyl sulfonimide (bis-FASI) ionic liquids were detected as bis(trifluoromethanesulfonyl)imide (NTf2-), two rarely reported homologues (±2 CF2, namely FSI- and BETI-), and two previously unreported homologues (±1 CF2, namely FTFSI- and FTNTf2-). Bis-FASIs were present in 85% of samples and were more abundant in effluents from larger WWTPs. The fluorinated anion PF6-, commonly used in ionic liquids, was found in all samples (≤3 μg/L). Hexafluoroarsenate (AsF6-), reported here for the first time in municipal wastewater, was detected in 32% of samples in eight countries. PF6- and AsF6- concentrations exceeded those of traditional PFSAs and PFCAs in 97% of the samples. No removal was detected for perfluorinated compounds, inorganic anions, and low-fluorinated pharmaceuticals and pesticides. Low-fluorinated substances were detected in 90% of samples (>100 ng/L), yet PF6- alone surpassed the combined concentration of all low-fluorinated substances in 27 out of 30 samples. These results reveal the significance of unconventional fluorinated substances for the overall fluorine load in wastewater, highlighting the need to extend monitoring strategies beyond legacy PFAS.}, issn = {0013-936X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alatalotarja_2025, title = {Nordic Preschool Teachers' Views of the Physical and Psychological Literacy Environments Regarding Read-Alouds}, author = {Alatalo, Tarja and Magnusson, Maria and Norling, Martina}, year = {2025}, journal = {Nordisk Barnehageforskning}, volume = {22}, number = {1}, pages = {7--27}, doi = {10.23865/nbf.v22.586}, url = {1935430}, language = {eng}, publisher = {Cappelen Damm Akademisk}, keywords = {attitudes; book resources; language stimulation; meanding-making; high-quality literacy environments}, abstract = {This research aims to increase knowledge about how preschool teachers in three Nordic countries view their preschool’s physical and psychological literacy environment regarding read-alouds. A total of 222 Nordic preschool teachers (52 Finnish, 91 Norwegian, and 79 Swedish) responded to a survey about early literacy practices. Likert-scale questions that contained statements about teachers’ views of the physical literacy environment and methods of reading aloud were used. Scales indicating a physical and psychological literacy environment were created based on statements that reflected the respective literacy environment. The results revealed that the teachers, on average, rated their preschool’s physical literacy environment positively. Their attitudes towards the psychological literacy environment were, on average, high regarding reading aloud as an opportunity for meaning-making and even higher for language-stimulating interaction. The attitudes towards reading aloud to organise everyday activities scored very low on average, which was a somewhat unexpected finding. There were some statistically significant differences in the measures between countries and groups, such as educational level. Emphasising high-quality literacy environments as early as for one- to three-year-old children is discussed as being essential in preschool teacher training and in-service training.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_callmersa_2025, title = {Normalising what’s outside the norm? The social life of consumption reduction}, author = {Callmer, Åsa and Boström, Magnus}, year = {2025}, journal = {Consumption and Society}, doi = {10.1332/27528499Y2025D000000058}, url = {1990574}, language = {eng}, publisher = {Bristol University Press}, keywords = {consumption reduction; sufficiency; sustainable consumption; normalisation; social norms}, abstract = {A better understanding of the factors at play in the normalisation of sustainable lifestyle choices is essential to achieve a large-scale transition to sufficiency-oriented lifestyles and societies. Aiming to contribute to this understanding, this article builds on literature on normativity and normalisation related to consumption and analyses interview material from a study with 25 Swedish individuals who aim to reduce their consumption. The analysis identifies both contextual and processual factors that dynamically interact in the process of normalising reduced consumption. The contextual factors are the cultural and social contexts shaping the ways consumption is practised, like social norms and sociomaterial infrastructures, but they also include the different settings where consumption is practised and talked about in everyday life, such as in the household, the workplace and with friends. The processual factors refer to factors of importance in the reduction process itself, such as the strengthening of reflexive capacity and the (re)negotiation of ‘normality’ through social interaction. Even if sociomaterial infrastructure and ideas of comfort act as barriers in the reduction process, we can discern a shift in norms around consumption in Sweden, towards normalising reduced consumption. The results show that renegotiating meanings and developing new competences and skills are important parts of normalising more sufficiency-oriented ways of consuming. They further suggest how everyday conversations and inspiring examples can help push the boundaries of what is perceived as ‘normal’ consumption, by initiating explicit negotiations about what consumption is acceptable in certain contexts.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hlmanchristoffer_2025_2, title = {Notions of “(un)sustainable” and “renewal” forests and forestry in the Nordics and in the Global South : A history of education study}, author = {Åhlman, Christoffer and Kortekangas, Otso}, year = {2025}, url = {1998261}, language = {eng}, abstract = {In our project, we investigate what different meanings (e.g., economic, ecological, cultural, recreational) school textbooks have presented about forests in Sweden and Finland (1972–today). Our ENIUGH paper will especially look at how the textbooks portray Swedish and Finnish forests and forestry in relation to forests and forestry in the Global South: whereas forestry in the Nordic countries is often described as “renewable” and “sustainable”, forest and biodiversity loss are conventionally portrayed as something taking place in the forests of the Global South (where Nordic forest companies are also active). This paper builds on a sample of textbooks from the subjects of biology, geography, social studies and history, asking how the binary “renewable” Nordic forests / “unsustainable” forests of the Global South relates to what we know of the sustainability of forests from other sources. The different textbooks offer conflicting and competing narratives over several decades that enable a critical discussion of this theme related to the conference themes “Nordic (post)colonialism” and “global environmental history”.      } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_thelinstefan_2025, title = {No-touch vein grafts in coronary artery bypass surgery : a registry-based randomized clinical trial}, author = {Thelin, Stefan and Modrau, Ivy Susanne and Duvernoy, Olov and Dalén, Magnus and Dreifaldt, Mats and Ericsson, Anders and Friberg, Örjan and Holmgren, Anders and Hostrup Nielsen, Per and Hultkvist, Henrik and Jensevik Eriksson, Karin and Jeppsson, Anders and Lidén, Mats and Nozohoor, Shahab and Ragnarsson, Sigurdur and Sartipy, Ulrik and Ternström, Lisa and Themudo, Raquel and Vikholm, Per and James, Stefan}, year = {2025}, journal = {European Heart Journal}, volume = {48}, number = {18}, pages = {1720--1729}, doi = {10.1093/eurheartj/ehaf018}, url = {1938919}, language = {eng}, publisher = {Oxford University Press}, keywords = {coronary artery disease; long-term outcomes; mortality; myocardial infarction; surgical complications}, abstract = {BACKGROUND AND AIMS: No-touch saphenous vein harvesting may enhance graft patency and improve clinical outcomes after coronary artery bypass grafting (CABG).METHODS: In this registry-based, randomized trial, patients undergoing CABG were randomly assigned to no-touch or conventional harvesting. The primary composite outcome was the proportion of patients with occluded/stenosed >50% vein graft on coronary computed tomography angiography, or who underwent percutaneous coronary intervention to a vein graft, or died. Secondary outcomes included clinical outcomes and leg wound complications.RESULTS: A total of 902 patients were enrolled with a mean total number of distal vein anastomoses of 2.0 (SD 0.87). The primary endpoint occurred in 90/454 (19.8%) of patients randomized to no-touch and in 107/446 (24.0%) of patients randomized to the conventional technique [difference, -4.3 percentage points; 95% confidence interval (CI) -10.1-1.6; P = .15] at a mean follow-up time of 3.5 (SD 0.1) years. The composite of death, myocardial infarction, or repeat revascularization at 4.4 (SD 1.3) years occurred in 57/454 (12.6%) and 44/446 (9.9%) in the no-touch and conventional groups, respectively (hazard ratio 1.3; 95% CI, 0.87-1.93). Leg wound complications were more common in patients assigned to no-touch harvesting at 3 months [107/433 (24.7%) vs. 59/427 (13.8%); difference, 10.9 percentage points; 95% CI 5.7-16.1]. At 2 years, 189/381 (49.6%) vs. 91/361 (25.2%) had remaining leg symptoms (difference, 24.4 percentage points; 95% CI 17.7-31.1).CONCLUSIONS: No-touch vein graft harvesting for CABG was not superior to conventional open harvesting in reducing vein graft failure or clinical events after CABG but increased leg wound complications. The primary outcome requires cautious interpretation due to a lower-than-expected number of primary events.}, issn = {0195-668X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_golpariandaniel_2025_2, title = {Novel approach using automated target enrichment enables culture-independent accurate whole-genome sequencing of Neisseria gonorrhoeae directly from clinical urogenital and extragenital specimens}, author = {Golparian, Daniel and Rapp, Ellionor and Hasmats, Johanna and Unemo, Magnus}, year = {2025}, journal = {Journal of Antimicrobial Chemotherapy}, volume = {80}, number = {2}, pages = {563--566}, doi = {10.1093/jac/dkae446}, url = {1921992}, language = {eng}, publisher = {Oxford University Press}, abstract = {OBJECTIVES: Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is compromising gonorrhoea treatment, and enhanced N. gonorrhoeae AMR and genome-based epidemiological surveillance is imperative. Molecular tests are replacing N. gonorrhoeae culture internationally, excluding possibilities to perform WGS. We describe and evaluate a novel approach using a custom SureSelectXTHS Target-Enrichment probe panel automated on the Magnis NGS Prep System and Illumina sequencing to generate accurate N. gonorrhoeae genomes directly from clinical urogenital and extragenital specimens.METHODS: One hundred thirteen clinical N. gonorrhoeae-positive APTIMA Combo 2 (AC2) specimens (with 89 linked N. gonorrhoeae isolates) were included. DNA was extracted using QIAsymphony DSP Virus/Pathogen kit. Amplisens multiplex RT-PCR assay (AM-PCR) identified 105 (92.9%) of the AC2 specimens as N. gonorrhoeae positive, which were further examined. Sequence libraries for AC2 specimens were prepared on the Magnis NGS Prep System using the Magnis SureSelectXTHS Reagent kit for Illumina paired-end platforms. Paired-end sequencing was performed on Illumina platforms. RESULTS: Seventy-four of the 105 (70.5%) AC2 samples remained N. gonorrhoeae positive with a cycle threshold <20 in the AM-PCR and subjected to SureSelectXTHS target enrichment and subsequently Illumina WGS. Seventy-two (97.3%) of all target-enriched specimens were successfully genome-sequenced. All linked AC2 specimens and N. gonorrhoeae isolates from the same anatomical site had identical AMR determinants and molecular epidemiological sequence types.CONCLUSIONS: We show that custom SureSelectXTHS target enrichment automated on the Magnis NGS Prep System, followed by Illumina sequencing, enables culture-independent genome-based surveillance of N. gonorrhoeae AMR and molecular epidemiology. This novel methodological advancement provides an efficient and accurate WGS of N. gonorrhoeae directly from clinical urogenital and extragenital NAAT specimens.}, issn = {0305-7453} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisi_2025_1, title = {NOVEL IGG AND IGA AUTOANTIBODIES DIFFERENTIATING SYSTEMIC LUPUS ERYTHEMATOSUS FROM PRIMARY SJÖGREN'S SYNDROME AND SYSTEMIC SCLEROSIS}, author = {Parodis, I. and Nikolopoulos, D. and Lindblom, J. and Beretta, L. and Cetrez, N. and Peyper, J. and Barturen, G. and Jakobsson, P. J. and Alarcon-Riquelme, M. and Idborg, H.}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {83}, number = {Suppl. 1}, doi = {10.1136/annrheumdis-2024-eular.6103}, url = {1953953}, language = {eng}, publisher = {Elsevier}, keywords = {autoantibodies; '-omics; biomarkers}, abstract = {Background: Connective tissue diseases (CTDs) including systemic lupus erythematosus (SLE), primary Sjögren’s syndrome (pSS) and systemic sclerosis (SSc) frequently share clinical and serological features, rendering precise differentiation challenging. Currently used autoantibodies (Abs) either demonstrate high sensitivity across all CTDs (e.g., ANA) or high specificity yet low sensitivity (e.g., anti-dsDNA, anti-Smith, anti-Scl70, anti-centromere). Better biomarkers for early and accurate diagnosis of CTDs are needed.Objectives: To perform a broad explorative screen of IgG and IgA antibodies to autoantigen specificities in SLE vs pSS and SSc to identify novel Abs that potentially could aid in distinguishing across CTDs.Methods: We analysed plasma samples from patients with SLE (n=289), pSS (n=208), and SSc (n=187) from the European PRECISESADS project (NTC02890121). Samples were screened for IgG and IgA seroreactivity against a panel of >1,600 protein autoantigens using KREX-based i-Ome arrays (Sengenics). Differential expression analysis was performed with the limma R package adjusting for e.g., polyspecific antibody reactivity. The level of significance for differentially expressed Abs (DEAbs) was set at p<0.05 and |fold change| >1.5. ROC analysis was carried out for each DEAb, yielding discriminative performance metrics e.g., sensitivity, specificity, area under the curve (AUC), and accuracy.Results: DEAb analysis revealed 10 IgG (8 upregulated; 2 downregulated) and 1 downregulated IgA DEAb in SLE vs pSS. Of upregulated IgG DEAbs in SLE, anti-LIN28A (sen=0.71, spe=0.75, AUC=0.78), anti-PCBP2 (sen=0.56, spe=0.80, AUC=0.74), anti-HNRNPA2B1 (sen=0.74, spe=0.64, AUC=0.72), anti-HMG20B (sen=0.57, spe=0.81, AUC=0.74), and anti-NRF1 (sen=0.78, spe=0.64, AUC=0.75) demonstrated the best ability to discriminate between SLE and pSS. As expected, anti-TROVE2 IgG (anti-SSA), anti-SSB IgG, and anti-SSB IgA were significantly higher in pSS vs SLE, yet with modest accuracy in differentiating between the two groups (sen=0.64, spe=0.78, AUC=0.70 for anti-TROVE2 IgG; sen=0.57, spe=0.79, AUC=0.65 for anti-SSB IgG; sen=0.38, spe=0.84, AUC=0.59 for anti-SSB IgA). Analysis of SLE vs SSc revealed 15 IgG (9 upregulated; 6 downregulated) and 4 upregulated IgA DEAbs. Of upregulated IgG DEAbs in SLE, anti-LIN28A (sen=0.67, spe=0.84, AUC=0.81), anti-HBGB2 (sen=0.61, spe=0.85, AUC=0.77), anti-HNRNPA2B1 (sen=0.74, spe=0.64, AUC=0.72), anti-HMG20B (sen=0.66, spe=0.81, AUC=0.79), and anti-NRF1 (sen=0.64, spe=0.82, AUC=0.77) demonstrated the best discriminative ability. Moreover, upregulated IgA DEAbs in SLE vs SSc including anti-LIN28A (sen=0.61, spe=0.91, AUC=0.83), anti-HMG20B (sen=0.78, spe=0.69, AUC=0.80), anti-NOL4 (sen=0.68, spe=0.75, AUC=0.76), and anti-SSB (sen=0.67, spe=0.83, AUC=0.81) showed good accuracy in differentiating between the two groups. This analysis also revealed 6 upregulated DEAbs in SSc vs SLE, i.e., anti-CXB5, anti-GGPS1, anti-CRISP2, anti-HSPE1, anti-TEX101, and anti-KRT19. While these Abs showed low discriminative capacity, anti-HSPE1 showed the greatest sensitivity (84%) and anti-CBX5 the greatest specificity (89%), with AUCs ranging from 60% to 65%.Conclusion: This study corroborated both classical IgG Ab specificities shared across CTDs (e.g., anti-SSB, anti-TROVE2) and specificities previously described (anti-LIN28A, anti-HBGB2, anti-HMG20B, anti-HNRNPA2B1)1 and identified novel IgG (anti-NRF1, anti-CCNB1) and novel IgA (anti-LIN28A, anti-NOL4, anti-HMG20B) Abs described for the first time in SLE, with robust accuracy in distinguishing SLE from pSS or SSc. Expression levels of anti-LIN28A, anti-HBGB2, anti-HMG20B, and anti-HNRNPA2B1 were significantly higher in SLE compared with both pSS and SSc, implying specificity for SLE. Importantly, many of these novel Abs outperformed the diagnostic and discriminative accuracy of currently used Abs, e.g., anti-dsDNA, anti-SSA, and anti-SSB.}, issn = {0003-4967} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindblomjulius_2025_1, title = {NOVEL IgG AND IgA AUTOANTIBODIES IN TWO INDEPENDENT COHORTS ASSOCIATE WITH GLOBAL AND ORGAN-SPECIFIC DISEASE ACTIVITY IN SYSTEMIC LUPUS ERYTHEMATOSUS : IMPLICATIONS FOR ANTI-LIN28A AND ANTI-IRF5}, author = {Lindblom, Julius and Lagutkin, Denis and Sherina, Natalia and Idborg, Helena and Beretta, Lorenzo and Borghi, Maria Orietta and Peyper, Janique M. and Barturen, Guillermo and Jakobsson, Per-Johan and Alarcón-Riquelme, Marta and Nikolopoulos, Dionysis and Parodis, Ioannis}, year = {2025}, journal = {Journal of Rheumatology}, volume = {52}, number = {Suppl. 1}, pages = {45--45}, doi = {10.3899/jrheum.2025-0390.O050}, url = {2014535}, language = {eng}, publisher = {The Journal of Rheumatology}, issn = {0315-162X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindblomjulius_2025_2, title = {Novel IgG and IgA autoantibodies validated in two independent cohorts are associated with disease activity and determine organ manifestations in systemic lupus erythematosus : implications for anti-LIN28A, anti-HMGN5, anti-IRF5, and anti-TGIF1}, author = {Lindblom, Julius and Lagutkin, Denis and Sherina, Natalia and Idborg, Helena and Beretta, Lorenzo and Borghi, Maria Orietta and Peyper, Janique M. and Barturen, Guillermo and Jakobsson, Per-Johan and Alarcón-Riquelme, Marta E. and Nikolopoulos, Dionysis and Parodis, Ioannis}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {84}, number = {7}, pages = {1164--1179}, doi = {10.1016/j.ard.2025.04.008}, url = {1957610}, language = {eng}, publisher = {Highwire Press}, abstract = {OBJECTIVES: This study aimed to identify and validate novel autoantibodies that reflect global and organ-specific disease activity in systemic lupus erythematosus (SLE).METHODS: Plasma samples were screened for IgG and IgA seroreactivity against 1609 protein autoantigens using a microarray (i-Ome Discovery; Sengenics). We determined differentially abundant autoantibodies (daAAbs) in patients with SLE vs healthy controls within a discovery (n = 196 vs n = 110; NTC02890121) and an independent validation cohort (n = 30 vs n = 83; NCT02890134) from the European PRECISESADS project. Validated daAAbs were analysed in relation to global and organ-specific disease activity using linear and logistic regression, along with daAAb target pathway enrichment analysis.RESULTS: We validated 89 IgG and 66 IgA daAAbs. IgG anti-LIN28A, IgG anti-HMGN5, and both isotypes for anti-IRF5 and anti-TGIF1 were associated with a SLE disease activity index 2000 score of ≥10, negatively associated with lupus low disease activity state, and highly prevalent in subgroups with active disease across organ manifestations. IgG anti-LIN28A levels exceeded the cutoff for positivity in 53% of patients with central nervous system (CNS) involvement, a prevalence higher than that observed for anti-double-stranded DNA (20%) and 47% of patients with renal activity. A cluster of IgG and IgA daAAbs against RNA-binding proteins, including anti-LIN28A, was linked to CNS involvement. IgA anti-FOSL2 was elevated uniquely in patients with musculoskeletal activity. Enriched pathways involving DNA binding and repair showed considerable overlap across manifestations.CONCLUSIONS: Novel IgG and IgA autoantibodies, including IgG anti-LIN28A, IgG anti-HMGN5, IgG and IgA anti-IRF5, and IgG and IgA anti-TGIF1 were associated with SLE disease activity and highly abundant across organ manifestations.}, issn = {0003-4967} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_maharjanurusha_2025, title = {Novel variants of tick-borne encephalitis virus from patient and tick samples in Norway}, author = {Maharjan, Urusha and Skudal, Hilde Kristin and Asghar, Naveed and Soleng, Arnulf and Johansson, Magnus and Lindstedt, Heidi Elisabeth Heggen and Koskela von Sydow, Anita and Pettersson, John H-O and Johansen, Wenche and Fevang, Børre and Bjerkreim, Randi and Basnet, Suyog and Vikse, Rose and Andreassen, Åshild K. and Alfsnes, Kristian}, year = {2025}, journal = {Ticks and Tick-borne Diseases}, volume = {16}, number = {4}, doi = {10.1016/j.ttbdis.2025.102501}, url = {1983225}, language = {eng}, publisher = {Elsevier}, keywords = {flaviviruses; norway; phylogeny; tick-borne encephalitis; tick-borne encephalitis virus; whole genome sequencing}, abstract = {The annual number of tick-borne encephalitis (TBE) cases in Norway has increased dramatically from 1 case in 1998 to 113 in 2023. Characterization of TBE virus (TBEV) genomes from both clinical samples and tick vectors is necessary to understand disease severity and transmission dynamics. However, clinical samples with intact virus are rare because TBE is usually diagnosed by serology in the post-viremic phase, when the viral load is low and undetectable by molecular methods such as polymerase chain reaction (PCR). To date, Mandal-2009 is the only TBEV sequence from Norway with complete virus genome, sequenced directly from the tick vector. We used a combined approach with newly designed overlapping primer pairs and nanopore sequencing together with Sanger sequencing to obtain nearly complete TBEV genomes from both patient and tick samples from Norway. The patient had severe TBE complicated with hemophagocytic lymphohistiocytosis (HLH). The patient and tick samples were collected 16 km apart, from Telemark and Vestfold Counties, respectively. Pairwise genomic comparison showed 99.7 % identity, and phylogenetic analysis revealed that these sequences were closely related to the TBEV strain from Kumlinge in Åland, Finland, rather than to the previously published Norwegian variant Mandal-2009. These findings confirm the existence of novel TBEV variants in the endemic areas of Telemark and Vestfold Counties of Norway. Our findings highlight the need for continuous monitoring and characterization of novel TBEV genomes in Norway and Europe.}, issn = {1877-959X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_acarfatma_2025, title = {Novice Mathematics Teachers' Level of Understanding of the Equal Sign and Equality : A Curtailing Interaction With Pedagogical Insights}, author = {Acar, Fatma and Sevinc, Serife and Uyguç Küçük, Ayşenur}, year = {2025}, journal = {School Science and Mathematics}, doi = {10.1111/ssm.18398}, url = {2006392}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {equal sign; teacher knowledge; understanding of equality}, abstract = {This study focused on prospective and in-service novice mathematics teachers' conceptualization of and pedagogical insights about the equal sign and equality. Towards this goal, we conducted online interviews with seven prospective and eight in-service mathematics teachers. We analyzed their descriptions and representations of equality and the equal sign using a theory-driven construct map to scale levels of understanding and the association between their level of understanding and pedagogical insights. We observed that all the teachers demonstrated a relational understanding of the equal sign, with some variation in the depth of their understanding. In addition, there were some discrepancies as well as consistencies in their responses regarding their understanding of the concept, their hypothetical teaching strategies, and their knowledge of how students think about the equal sign and equality. Some did not maintain the level of their understanding of the equal sign while articulating teaching strategies. This demonstrated a curtailing interaction between novice teachers' content knowledge and their pedagogical insights, the implications of which were discussed in relation to research and practice.}, issn = {0036-6803} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_eldhanncatrine_2025, title = {Nuancing the continuum from ideal to real-world implementation : a letter to the editor on Nilsen et al}, author = {Eldh, Ann Catrine and Bergström, Anna and Hälleberg-Nyman, Maria and Kim, Bo and Rycroft-Malone, Jo}, year = {2025}, journal = {Implementation Science Communications}, volume = {6}, number = {1}, doi = {10.1186/s43058-025-00813-x}, url = {2010731}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {commentary; evidence; facilitation; healthcare; implementation intervention}, abstract = {Nilsen et al.'s (Implement Sci Commun 6:90, 2025) proposal to distinguish between implementation efficacy and effectiveness, and to situate implementation studies along a continuum from ideal to real-world conditions, offers a valuable conceptual advance. In this commentary, we acknowledge the contribution of their debate while highlighting potential limitations of applying a single-axis continuum to a field heavily characterized by contextual complexity. Drawing from decades of healthcare quality improvement, we argue that implementation interventions often blend efficacy-like and effectiveness-like elements, making neat classification difficult. We further suggest that oversimplification risks obscuring the realities of organizational change. Instead, we propose a double-axis model that considers both the implementation intervention and the context in which it unfolds. Economic evaluation likewise requires nuanced approaches that go beyond their proposed continuum indicator tool ("Implementation PRECIS"). To constructively extend Nilsen et al.'s contribution, we advocate for integration of the tool with existing approaches to evaluation, co-production with stakeholders, and empirical validation across diverse settings. While no implementation endeavor is ideal, advancing discourse around how efficacy and effectiveness are conceptualized can support more pragmatic, context-responsive, and sustainable improvements in healthcare.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stenbergamanda_2025, title = {Nuclear error phenotypes in the two-cell embryo are correlated to blastocyst formation rate after assisted reproduction}, author = {Stenberg, Amanda and Baumgart, Juliane and Adolfsson, Emma}, year = {2025}, journal = {Journal of Assisted Reproduction and Genetics}, volume = {42}, number = {1}, pages = {115--124}, doi = {10.1007/s10815-024-03354-9}, url = {1925710}, language = {eng}, publisher = {Springer-Verlag New York}, keywords = {assisted reproduction technology; blastocyst formation rate; nuclear error phenotypes; time-lapse imaging; two-cell stage embryos}, abstract = {PURPOSE: Map the nuclear error phenotypes in the two-cell embryo after assisted reproduction using time lapse images and the effect on good quality blastocyst formation.METHODS: Retrospective cohort study using time lapse images, categorizing 2331 two-cell embryos from 392 patient couples and 504 ART cycles categorizing each embryo as mononucleated, multinucleated, micronucleated, binucleated, split nucleation or mixed error. Correlating nuclear error phenotype with good quality blastocyst formation rate (BFR) using contingency tables and unadjusted odds ratio.RESULTS: An overall nuclear error rate of 47.1% was observed in two-cell embryos. The most frequent error was multi-nucleation (14.2%) followed by mixed error (11%), micro-nucleation (8.6%), bi-nucleation (7.4%) and split nucleation (5.8%). Blastocyst formation rate (BFR) was reduced in embryos with nuclear errors, 46.2% for embryos with one cell affected, 27.6% for embryos with both cells affected, compared to 58.6% for mononucleated cells, p < 0.001 for both. Binucleated embryos were as likely as mononucleated embryos to become clinically useful blastocysts (56.8% vs 58.6%, n.s., unadjusted OR 0.94), whereas all the other phenotypes were less likely to develop into good quality blastocysts. The worst outcome was noted for embryos with split nucleation, with just 12.4% BFR, OR 0.12 (0-08-0.21), p < 0.001.CONCLUSION: Nuclear errors are common at the two-cell stage. Overall, presence of nuclear errors reduces the likelihood of becoming good quality blastocysts. Both the number of affected cells and the different nuclear error phenotypes have impact on blastocyst formation rate, except binucleated embryos.}, issn = {1058-0468} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_razavihomiea_2025, title = {Number of people treated for hepatitis C virus infection in 2014-2023 and applicable lessons for new HBV and HDV therapies}, author = {Razavi, Homie A. and Duberg, Ann-Sofi and Zuckerman, Eli}, year = {2025}, journal = {Journal of Hepatology}, volume = {83}, number = {2}, pages = {329--347}, doi = {10.1016/j.jhep.2025.01.013}, url = {1935524}, language = {eng}, publisher = {Elsevier}, keywords = {global; polaris observatory; regions; who regions; world bank regions}, abstract = {BACKGROUND AND AIMS: The year 2023 marked the 10-year anniversary of the launch of direct-acting antivirals (DAAs) for the treatment of the hepatitis C virus (HCV). HCV treatment trends by country, region, and globally are important to monitor progress toward the World Health Organization's 2030 elimination targets. Additionally, the historical patterns can help predict the treatment uptake for future therapies for other liver diseases.METHODS: The number of people living with HCV (PLHCV) treated between 2014-2023 across 119 countries was estimated using national HCV registries, reported DAA sales data, pharmaceutical companies' reports, and estimates provided by national experts. For the countries with no available data, the average estimate of the corresponding Global Burden of Disease region was used.RESULTS: An estimated 13,816,000 (95% uncertainty intervals (UI): 13,221,000-16,415,000) PLHCV were treated, of whom 12,748,000 (12,226,000-15,231,000) were treated with DAAs, of which 11,081,000 (10,542,000-13,338,000) were sofosbuvir-based DAA regimens. Country-level data accounted for 97% of these estimates. In high-income countries, there was a 41% drop in treatment from its peak, and reimbursement was a large predictor of treatment. In low- and middle-income countries, price played an important role in expanding treatment access through the public and private markets, and treatment continues to increase slowly after a sharp drop at the end of the Egyptian national program.CONCLUSIONS: In the last 10 years, 21% of all HCV infections were treated with DAAs. Regional and temporal variations highlight the importance of active screening strategies. Without program enhancements, the number of treated PLHCV stalled in every country/region which may not reflect a lower prevalence but may instead reflect the diminishing returns of the existing strategies.IMPACT AND IMPLICATIONS: Long-term hepatitis C virus (HCV) infection can lead to cirrhosis and liver cancer. Since 2014, these infections can be effectively treated with 8-12 weeks of oral therapies. In 2015, the World Health Organization (WHO) established targets to eliminate HCV by 2030, which included treatment targets for member countries. The current study examines HCV treatment patterns across 119 countries and regions from 2014 to 2023 to assess the impact of national programs. This study can assist physicians and policymakers in understanding treatment patterns within similar regions or income groups and in utilizing historical data to refine their strategies in the future.}, issn = {0168-8278} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_fatemihajar_2025, title = {Numbers vs. Words : Investigating the Impact of Information Format on Supporting Environmental Public Policies}, author = {Fatemi, Hajar and Rezvani, Zeinab}, year = {2025}, url = {2015631}, language = {eng}, keywords = {information format; communication; environmental policy support; consideration of future consequences; experiment}, abstract = {Purpose: This research intends to show the role of communicating information about environmental issues in quantitative, i.e. numeric, versus qualitative, i.e., textual, format in enhancing individuals’ support for environmental public policies.Design: We used four experimental studies to test the hypotheses.Findings: The results of our studies show that when receiving quantitative information, the support for environmental policies increases due to a higher evaluation of environmental issues' importance. We rule out alternative explanations for this effect and propose a boundary condition. Our findings show that quantitative information significantly motivates individuals with low, but not the ones with high, consideration of future consequences to show higher support for environmental policies. This paper has important theoretical and practical implications for social marketing and environmental policy promotion.Originality: We are the first to show that environmental information format, impacts environmental policy support by providing a mechanism (perceived importance of environmental issues), and a boundary condition (consideration of future consequences).} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kosteriaioanna_2025, title = {Numeracy Skills and Glycemic Control in an Observational, Multicenter, Cross-Sectional, and International Study of Children with Type 1 Diabetes}, author = {Kosteria, Ioanna and Jarosz-Chobot, Przemyslawa and de Beaufort, Carine and Barrett, Timothy G. and Becker, Marianne and Cameron, Fergus and Castaño, Luis A. and Castro-Correia, Cintia and Palmert, Mark and Polanska, Joanna and Särnblad, Stefan and Skinner, Timothy C. and Svensson, Jannet}, year = {2025}, journal = {Hormone Research in Paediatrics}, doi = {10.1159/000545419}, url = {1970071}, language = {eng}, publisher = {S. Karger}, keywords = {adolescents; cgm; csii; children; dnt-5; hba1c; mdi; numeracy skills; numeracy test; self-care; type 1 diabetes; wmt}, abstract = {AIMS: This study examined the possible association between numeracy skills and glycemic outcomes in children with type 1 diabetes.METHODS: The study used a cross-sectional design and collected data from 7 centers of the Hvidoere Study Group. HbA1c was measured centrally. Numeracy was assessed using the specific 5-item Diabetes Numeracy Test (DNT-5) and the international, general Wordless Mathematical Test (WMT). The HbA1c predictive multivariate generalized linear model was constructed using the adjusted R-squared index for model selection. Pearson's correlation coefficient was calculated between observed and predicted HbA1c levels in the training and testing datasets.RESULTS: Overall,306 adolescents aged 12-18 (mean age 14.96 ± 1.68) years and diabetes duration of 6.57 (±3.75) participated in this study. Numeracy skills, as assessed by the WMT but not DNT-5, predicted the HbA1c levels after adjustment for sociodemographic and clinical factors. The correlation between observed and predicted HbA1c levels was consistent in both datasets and was 0.34 (N = 155) and 0.37 (N = 61) for the training and test datasets, respectively (p = 0.412). The effect size for the WMT-based predictive model of HbA1c adjusted for clinical and socioeconomic factors was significantly higher (p < 0.05) than the single-parameter-based model.CONCLUSIONS: Numeracy, as assessed by an international general math test, is a good predictor of HbA1c in children and adolescents with type 1 diabetes. The basic and short WMT is a potentially effective tool in personalized clinical pediatric diabetes practice. Therapy planning should consider adjusting therapy to compensate for lower numeracy skills and/or training to improve the patient's numerical proficiency.}, issn = {1663-2818} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lvdahljenny_2025, title = {Nurse-Administered Gut-Directed Hypnotherapy for Irritable Bowel Syndrome : A Two-Year Follow-Up Study}, author = {Lövdahl, Jenny and Blomqvist-Storm, Michaela and Palsson, Olafur S. and Ringström, Gisela and Törnblom, Hans and Simrén, Magnus and Trindade, Ines}, year = {2025}, journal = {United European Gastroenterology journal}, volume = {13}, number = {7}, pages = {1307--1317}, doi = {10.1002/ueg2.70060}, url = {1968829}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {extracolonic symptom; gut‐brain axis; hypnotherapy; irritable bowel syndrome; nurse; psychological treatment}, abstract = {BACKGROUND: Gut-directed hypnotherapy is effective for irritable bowel syndrome (IBS) and a few studies have reported long-lasting therapeutic effects following intervention. No previous studies have evaluated the long-term effects of nurse-administered hypnotherapy.AIMS: We aimed to investigate the long-term effects of nurse-administered gut-directed hypnotherapy for IBS and identify factors associated with symptom improvement. Furthermore, we aimed to compare treatment effects between individual and group hypnotherapy.METHODS: A 2-year follow-up study including 289 patients with IBS who had completed a 12-week hypnotherapy program (individually or in groups) was conducted. Data were collected at baseline, and at 6-month-, 1-year- and 2-year follow-ups. Irritable bowel syndrome and extracolonic symptom severity (IBS-SSS), gastrointestinal-specific anxiety (VSI), and anxiety and depressive symptoms (HADS) were assessed. Patients reporting a reduction ≥ 50 points (IBS-SSS) were classified as treatment responders.RESULTS: The 2-year follow-up was completed by 207 patients. The proportion of responders at post-treatment was 64.3%, 62.8% at the 6-month follow-up, 64.7% at the 1-year follow-up, and 61.8% at the 2-year follow-up. The severity of IBS symptoms, extracolonic and psychological symptoms were all reduced post-treatment, and this effect lasted over the 2-year follow-up period (p < 0.001). Younger age, individual hypnotherapy, and severe irritable bowel syndrome symptoms at baseline predicted a better response to treatment (R2 = 0.16).CONCLUSIONS: Nurse-administered gut-directed hypnotherapy is an effective treatment for IBS with long-lasting symptom improvements. Younger age, severe irritable bowel syndrome symptoms, and individual treatment might be important factors associated with effectiveness (ClinicalTrials.gov study protocol IDs: NCT06167018, NCT03432078).TRIAL REGISTRATION: ClinicalTrials.gov study protocol IDs: NCT06167018, NCT03432078.}, issn = {2050-6406} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stenvalljenny_2025, title = {Nurses' Experiences of Psychological Safety in Ad Hoc Teams During Emergency Care : An Interview Study}, author = {Stenvall, Jenny and Edelbring, Samuel}, year = {2025}, journal = {Journal of Advanced Nursing}, doi = {10.1111/jan.70413}, url = {2023882}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {ad hoc teams; collaboration; emergency care; leadership; nurse; organisational culture; psychological safety; team dynamics; trust}, abstract = {AIM: To investigate specialist nurses' experience of psychological safety in ad hoc teams during emergency care.DESIGN: Interpretive descriptive qualitative study. METHODS: Semi-structured interviews with nine specialist nurses were conducted in Sweden from May to June 2024 and analysed using reflexive thematic analysis (Braun & Clarke).RESULTS: Four themes were identified: Interpersonal skills: implications for psychological safety; Individuality and team dynamics; Confidence, competence and collaboration; and Organisational responsibility for promoting psychological safety.CONCLUSION: Psychological safety in ad hoc emergency care teams is a fragile and multifaceted phenomenon, shaped by interpersonal skills, leadership and organisational culture. Supportive environments characterised by open communication and proactive leadership enable specialist nurses to collaborate confidently and safely, even under acute stress. Targeted efforts to strengthen these factors are essential for optimising teamwork and patient outcomes.IMPLICATIONS FOR THE PROFESSION: The psychological safety implications for specialist nurses in ad hoc teams during emergency care are profound. Psychological safety fosters an environment that empowers nurses to leverage clinical expertise, collaborate in ad hoc teams and improve patient outcomes. Promoting psychological safety ensures specialist nurses feel respected, valued and secure, leading to better care and a more resilient workforce.IMPACT: This qualitative study investigated specialist nurses' experience of psychological safety in ad hoc teams in acute care. The results will influence the awareness of nurses, specialist nurses, other professions, managers and organisations about the importance of feeling psychologically safe.REPORTING METHOD: Presentation follows COREQ 32-item checklist.PATIENT AND PUBLIC INVOLVEMENT: No patient or public involvement.CONTRIBUTION TO GLOBAL COMMUNITY: Shows that psychological safety helps nurses perform in ad hoc emergency teams. Identifies key factors that affect teamwork and patient care.}, issn = {0309-2402} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dasilvacinthiavianabandeira_2025, title = {Nurses' knowledge of skin tears : A cross-sectional survey study across four hospitals in São Paulo, Brazil}, author = {da Silva, Cinthia Viana Bandeira and Beeckman, Dimitri and de Gouveia Santos, Vera Lucia Conceição}, year = {2025}, journal = {Journal of tissue viability}, volume = {34}, number = {2}, doi = {10.1016/j.jtv.2025.100874}, url = {1941703}, language = {eng}, publisher = {Elsevier}, keywords = {continuing nursing; education; enterostomal therapy; knowledge; wounds and injuries}, abstract = {OBJECTIVES: This study aimed to assess and analyze nurses' knowledge regarding Skin Tears (STs).METHODS: An observational, exploratory, and cross-sectional study was conducted across four hospitals in São Paulo, Brazil, encompassing diverse settings: two public hospitals (one affiliated with a university and the other serving state public service professionals) and two private hospitals (one specializing in highly complex cases and the other a general hospital). Data collection involved two instruments: one for sample characterization and another, the OASES instrument, which was translated and content-validated for use in Brazilian Portuguese, to assess nurses' knowledge on STs. Data were analyzed using measures of central tendency and variability.RESULTS: The study included 179 nurses, with an average score of 10.83 (SD = 3.32). Higher knowledge levels were observed in nurses who had received training on STs (p = 0.003) and those who participated in scientific activities (p < 0.001).CONCLUSIONS: Nurses across the four hospitals in São Paulo demonstrated a level of knowledge about STs that was slightly higher compared to international benchmarks in similar studies.}, issn = {0965-206X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_justesenlise_2025_1, title = {Nursing home meals as social practices : Room for improvement}, author = {Justesen, Lise and Overgaard, Svend Skafte and Walter, Ute and Kristensen, Niels Heine and Beck, Anne Marie}, year = {2025}, journal = {International Journal of Gastronomy and Food Science}, volume = {40}, doi = {10.1016/j.ijgfs.2025.101173}, url = {1953839}, language = {eng}, publisher = {Elsevier}, keywords = {nursing home; meal practices; hospitality; social practices; rehabilitation; older adults}, abstract = {Meal situations in nursing homes are crucial for residents' identity and quality of life but are often impacted by physical and mental impairments. This ethnographic study conducted in a Danish nursing home aims to explore meal practices as a social practice through eleven interviews with residents and four interviews with healthcare professionals, 100 h of observations, visual methods and thematic analysis. Five meal practices were identified: Convivial-Meal-Practice, Healthy-Meal-Practice, Meal-Practice-as-Before, Hotel-Meal-Practice and Hospitable-MealPractice. These practices diverged and were contradictory despite a common goal. The nursing home attempted to replicate a home-like feeling through an individualized approach intertwined with health and convivialityfocused hotel practices, hindering residents from becoming part of a meal community. Hospitality actions and less structured meals allowed residents to engage socially. Recognizing and addressing individual and communal needs can enhance commensality and contribute to a greater focus on the potential of meal situations including meals as an arena for rehabilitation.}, issn = {1878-450X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ericsonjessica_2025, title = {Nutritional outcomes and impact of malnutrition in a randomised comparison between standard and prolonged time to surgery after neoadjuvant chemoradiotherapy for oesophageal cancer}, author = {Ericson, Jessica and Klevebro, Fredrik and Sunde, Berit and Szabo, Eva and Halldestam, Ingvar and Smedh, Ulrika and Wallner, Bengt and Johansson, Jan and Johnsen, Gjermund and Aahlin, Eirik Kjus and Johannessen, Hans-Olaf and Hjortland, Geir-Olav and Lorentzen, Sissi Stove and Slott, Malene and Schröder, Wolfgang and Rouvelas, Ioannis and Nilsson, Magnus}, year = {2025}, journal = {European Journal of Surgical Oncology}, volume = {51}, number = {9}, doi = {10.1016/j.ejso.2025.110228}, url = {1976578}, language = {eng}, publisher = {Elsevier}, keywords = {malnutrition; neoadjuvant treatment; oesophageal cancer; postoperative outcomes; time to surgery; weight loss}, abstract = {BACKGROUND: Prolonged time to surgery (TTS) after neoadjuvant chemoradiotherapy (nCRT) may enable malnourished oesophageal cancer patients' nutritional status to recover better, possibly improving outcomes with fewer complications and better overall survival (OS) after oesophagectomy.METHODS: This is a substudy within a multicentre randomised controlled trial comparing outcomes in patients with oesophageal cancer after standard TTS of 4-6 weeks to prolonged TTS of 10-12 weeks after nCRT. Patients were categorised as malnourished or non-malnourished at baseline and compared regarding weight, dysphagia, postoperative complications, and OS.RESULTS: The mean weight from baseline to time of surgery decreased significantly in patients allocated to standard TTS (p < 0.001) while patients with prolonged TTS recovered during the extended time to similar weight as at baseline (p = 0.131). The mean dysphagia score at the time of surgery improved significantly in both groups (p < 0.001). There were no significant differences between patients allocated to standard versus prolonged TTS regarding postoperative complications, regardless of malnourishment status at baseline. No significant differences in OS after prolonged TTS compared to standard TTS, was observed in neither malnourished patients (hazard ratio, HR 1.72 (95 %, CI: 0.82-3.59, p = 0.147) nor non-malnourished patients (HR 1.26 (95 % CI:0.82-1.94, p = 0.291).CONCLUSIONS: Prolonged TTS was associated with better weight recovery at the time of surgery compared to standard TTS. Patients malnourished at baseline did not benefit in terms of less postoperative complications after prolonged TTS.}, issn = {0748-7983} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_22, title = {Ny reglering om beskattning av inlösenaktier}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031704}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 1 januari 2025 trädde nya regler om beskattning av tilldelning av inlösenaktier i kraft. Vissa sådana tilldelningar ska nu beskattas som utdelning i stället för, som tidigare, kapitalvinst. Professor Eleonor Kristoffersson berättar om de nya reglerna.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_23, title = {Nya mervärdesskatteregler för beskattningsbara personer med liten årsomsättning}, author = {Kristoffersson, Eleonor}, year = {2025}, journal = {Svensk skattetidning}, number = {3}, pages = {237--244}, url = {2031811}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {mervärdesskatt}, issn = {0346-2218} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bageriushenric_2025_3, title = {När kroppar i badkläder framhäver det nakna}, author = {Bagerius, Henric}, year = {2025}, journal = {Nerikes Allehanda}, number = {11 november}, pages = {6--7}, url = {2026849}, language = {swe}, publisher = {Nerikes allehanda AB}, issn = {1103-971X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lundellpatrik_2025, title = {Något gammalt, något nytt, något lånat : Textåterbruk inom Sverige, Finland och Svensk-Amerika 1645-1918}, author = {Lundell, Patrik and Edoff, Erik and Paju, Petri and Marjanen, Jani and Rantala, Heli and Salmi, Hannu}, year = {2025}, journal = {Mediehistorisk årsbok}, pages = {183--207}, url = {1960621}, language = {swe}, publisher = {Svensk mediehistorisk förening}, issn = {0282-020X} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_krzyzanowskanatalia_2025, title = {O upamietnieniu, pamieci i dyskursie : Mapa wzajemnych inspiracji i powiazan}, author = {Krzyzanowska, Natalia}, year = {2025}, pages = {167--197}, url = {2039462}, language = {pol}, publisher = {Fundacja Concilium Civitas} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_casasgarciabeln_2025, title = {Observer- and sequence variability in personalized 4D flow MRI-based cardiovascular models}, author = {Casas Garcia, Belén and Tunedal, Kajsa and Viola, Federica and Cedersund, Gunnar and Carlhäll, Carl-Johan and Karlsson, Matts and Ebbers, Tino}, year = {2025}, journal = {Scientific Reports}, volume = {15}, number = {1}, doi = {10.1038/s41598-024-84390-4}, url = {1925951}, language = {eng}, publisher = {Nature Publishing Group}, abstract = {Subject-specific parameters in lumped hemodynamic models of the cardiovascular system can be estimated using data from experimental measurements, but the parameter estimation may be hampered by the variability in the input data. In this study, we investigate the influence of inter-sequence, intra-observer, and inter-observer variability in input parameters on estimation of subject-specific model parameters using a previously developed approach for model-based analysis of data from 4D Flow MRI acquisitions and cuff pressure measurements. The investigated parameters describe left ventricular time-varying elastance and aortic compliance. Parameter reproducibility with respect to variability in the MRI input measurements was assessed in a group of ten healthy subjects. The subject-specific parameters had coefficient of variations between 2.6 and 35% in the intra- and inter-observer analysis. In comparing parameters estimated using data from the two MRI sequences, the coefficients of variation ranged between 3.3 and 41%. The diastolic time constant of the left ventricle and the compliance of the ascending aorta were the parameters with the lowest and the highest variability, respectively. In conclusion, the modeling approach allows for estimating left ventricular elastance parameters and aortic compliance from non-invasive measurements with good to moderate reproducibility concerning intra-user, inter-user, and inter-sequence variability in healthy subjects.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_westerholtmarc_2025_1, title = {Occurrence and potential implications of the hook effect in a Borrelia burgdorferi IgG antibody chemiluminescence immunoassay}, author = {Westerholt, Marc and Kjerstadius, Torbjörn and Ocias, Lukas}, year = {2025}, journal = {European Journal of Clinical Microbiology and Infectious Diseases}, volume = {44}, number = {8}, pages = {1953--1958}, doi = {10.1007/s10096-025-05172-y}, url = {1960009}, language = {eng}, publisher = {Springer}, keywords = {borrelia serology; diasorin; dilution recommendation; dilution threshold; igg antibodies; immunoassay optimization; liaison borrelia igg immunoassay; lyme disease diagnostics; overdilution; prozone phenomenon}, abstract = {PURPOSE: Lyme borreliosis is diagnosed based on clinical symptoms and serological analysis, with high IgG antibody levels associated with late manifestations. Immunoassays with a broad detection range can exhibit a hook effect, leading to false-low results and potential misdiagnosis. This study aimed to investigate the occurrence of the high-dose hook effect and determine a dilution threshold to detect the hook effect and avoid overdilutions for the Liaison Borrelia IgG immunoassay.METHODS: In a two-year period, 5639 patient samples analysed for Borrelia antibodies were screened at Karlstad Hospital, Sweden. Samples with IgG ≥ 75 AU/mL and < 75 AU/mL with detectable IgM underwent 1:10 dilution, with a further 1:50 dilution for samples with IgG > 240 AU/mL. A Gaussian Mixture Model was used to group samples with and without hook effect. RESULTS: Of 389 samples eligible for dilution, 262 with IgG < 240 AU/mL were analysed. Of these, 70 (26.7%) showed hook effect, corresponding to 18% of included and 1.2% of all screened samples. Overdilution occurred in 58 (22.1%) diluted samples. Dilution thresholds of 98.7 and 96 AU/mL detected 95% of hook effect and overdilution samples, respectively.CONCLUSION: A substantial number of samples showed hook effect, which could lead to missed late Lyme borreliosis manifestations and inaccurate intrathecal index calculations. A dilution threshold of 98.7 AU/mL in the Liaison Borrelia IgG immunoassay effectively identified 95% of hook effect and avoided more than 95% of overdilutions.}, issn = {0934-9723} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mediana_2025, title = {Occurrence of microplastics in bottled water from Croatia : a Raman spectroscopy approach}, author = {Medić, Ana and Fiedler, Heidelore and Selvam, TamilSelvi and Grošev, Vlasta Mohaček and Lovković, Sandy and Mikac, Lara and Ivanda, Mile}, year = {2025}, journal = {Environmental Science and Pollution Research}, volume = {32}, pages = {13918--13931}, doi = {10.1007/s11356-025-36457-6}, url = {1958698}, language = {eng}, publisher = {Springer}, keywords = {contamination; mp size; micro-raman; microplastics (mps); mineral water; polymers}, abstract = {The occurrence of microplastics (MPs) in bottled water is still largely unexplored in Croatia. This study fills this gap by analysing six water brands available on the Croatian market, all bottled in either virgin or recycled polyethylene terephthalate (PET). In order to analyse microplastics down to a size of 1 µm, the water from the purchased bottles was filtered with silicon filters with a pore size of 1 µm and then micro-Raman spectroscopy was performed. A significant reduction in analysis time was achieved by using a randomly selected filter area of 12.05 mm2 instead of the conventional 100 mm2. The results showed that polyethylene (PE), PET, and polyamide (PA) were found in all six brands and the blank. The highest detection frequency was found for PE (N = 19), followed by PET (N = 17) and PA (N = 14). Polyvinyl chloride (PVC) was found only in one brand, but in all three subsamples, packaged in recycled PET. By far the highest detection frequency of MPs occurred in the smallest fraction at a length < 5 µm. The highest number of MPs was for PET with 45% of the total amount, followed by PE (37%). Although MPs were identified in the blank water sample, the number was 12% of the total. Interestingly, the bottled water in virgin PET containers had more MPs than that in recycled PET. It should be noted that the purification system used to produce ultrapure water produced MPs, which poses an additional analytical challenge. The results should be considered as a snapshot and further monitoring is necessary to assess the extent of MP contamination of drinking water and to characterise the types of polymers and sources of the MPs. The current findings raise concerns about the presence of MPs in bottled water and warrant a thorough risk assessment to evaluate potential long-term health effects on humans.}, issn = {0944-1344} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_umairmuhammad_2025_1, title = {OculusNet : Detection of Retinal Diseases Using A Tailored Web-Deployed Neural Network and Saliency Maps for Explainable AI}, author = {Umair, Muhammad and Ahmad, Jawad and Saidani, Oumaima and Alshehri, Mohammed and Al Mazroa, Alanoud and Hanif, Muhammad and Ullah, Rahmat and Khan, Muhammad Shahbaz}, year = {2025}, journal = {Frontiers in Medicine}, volume = {12}, doi = {10.3389/fmed.2025.1596726}, url = {1978897}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {retina; retinal disorder; explainable ai; ophthalmic imaging; neural networks}, abstract = {Retinal diseases are among the leading causes of blindness worldwide, requiring early detection for effective treatment. Manual interpretation of ophthalmic imaging, such as optical coherence tomography (OCT), is traditionally time-consuming, prone to inconsistencies, and requires specialized expertise in ophthalmology. This study introduces OculusNet, an efficient and explainable deep learning (DL) approach for detecting retinal diseases using OCT images. The proposed method is specifically tailored for complex medical image patterns in OCTs to identify retinal disorders, such as choroidal neovascularization (CNV), diabetic macular edema (DME), and age-related macular degeneration characterized by drusen. The model benefits from Saliency Map visualization, an Explainable AI (XAI) technique, to interpret and explain how it reaches conclusions when identifying retinal disorders. Furthermore, the proposed model is deployed on a web page, allowing users to upload retinal OCT images and receive instant detection results. This deployment demonstrates significant potential for integration into ophthalmic departments, enhancing diagnostic accuracy and efficiency. In addition, to ensure an equitable comparison, a transfer learning approach has been applied to four pre-trained models: VGG19, MobileNetV2, VGG16, and DenseNet-121. Extensive evaluation reveals that the proposed OculusNet model achieves a test accuracy of 95.48% and a validation accuracy of 98.59%, outperforming all other models in comparison. Moreover, to assess the proposed model's reliability and generalizability, the Matthews Correlation Coefficient and Cohen's Kappa Coefficient have been computed, validating that the model can be applied in practical clinical settings to unseen data.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_vanbellejono_2025_3, title = {Off the beaten track : Birgitta steene's pioneering reception research on Ingmar Bergman}, author = {Van Belle, Jono}, year = {2025}, pages = {16--36}, url = {2029884}, language = {eng}, publisher = {Berghahn Books} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_deboisesam_2025_3, title = {Oh brother where art thou? Between fratriarchies, broligarchies and bros}, author = {de Boise, Sam}, year = {2025}, journal = {Norma}, volume = {20}, number = {3}, pages = {177--183}, doi = {10.1080/18902138.2025.2529745}, url = {1988737}, language = {eng}, publisher = {Taylor & Francis}, issn = {1890-2138} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrkvallanders_2025_3, title = {Old codifications, traditional practices? The semiotic design of a South African high performance gym}, author = {Björkvall, Anders}, year = {2025}, pages = {67--82}, url = {1993781}, language = {eng}, publisher = {Örebro universitet}, keywords = {south africa; gym discourse; high performance gym; affordance; crossfit; semiotic regime; stellenbosch university; indexical trace; provenance}, abstract = {As a tribute to professor Per Ledin, his analysis of the CrossFit gym is taken as a point of departure for an analysis of another gymnasium, which – at least on the surface – has a different design. I look closer at a South African gym – Maties “high performance” gym – that, to me, seems not to connect to the same neoliberal discourses that Ledin and Machin have identified in the CrossFit gym. The aim of the analysis is to identify affordances of the design of a gym other than the CrossFit gym in order to answer to following questions: Are other training practices invited by the affordances in the so called “high performance” gym? If so, are they still neoliberal in the sense that Ledin and Machin describe practices in the CrossFit ‘box’ (that is, the main area of CrossFit gym)? The analyis identifies obvious differences between the CrossFit gym analyzed by Ledin and Machin and the Maties high performance gym in South Africa. Whereas the former has a provenance in a branded American movement which combines fitness and weight training, the latter connects more to traditional, sportspecific weightlifting practices. }, file = {https://oru.diva-portal.org/smash/get/diva2:1993781/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wallrothveronika_2025, title = {Older Adults' Experience of a Mobile Geriatric Team}, author = {Wallroth, Veronika and Larsson, Kjerstin and Schröder, Agneta}, year = {2025}, journal = {Ageing International}, volume = {50}, number = {3}, doi = {10.1007/s12126-025-09615-x}, url = {1993954}, language = {eng}, publisher = {Springer}, keywords = {phenomenology; older adults; mobile geriatric team (mgt); treatment at home}, abstract = {The aim of this study is to examine older adults' experience of receiving medical and care efforts from a Mobile Geriatric Team (MGT). A phenomenologically inspired approach guides this study to stay empirically close to the data while exploring the experiences of five older adults with comorbidity receiving medical and care efforts from a MGT. Three themes emerged from the interviews: The relief of integrated treatment, Reclaiming time from the emergency room, and Finding sanctuary at home. The findings reveal that older adults particularly valued the MGT's comprehensive view of their medical history and medication, highlighting how this holistic approach provided significant comfort. Participants also emphasized the relief brought by staff continuity and the ability to receive acute medical treatments in the familiarity of their own homes, thereby avoiding the stress and inconvenience of emergency room visits. While reducing emergency room visits was a stated goal of the MGT, this study distinctively illuminates the profound positive impact of this outcome from the older adults' perspective. These findings demonstrate a project successfully aligning with initiatives for good, close, and coordinated care, ultimately promoting health and well-being for older adults.}, issn = {0163-5158} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nilssonulrica_2025, title = {Older Patients' Postoperative Neurocognitive Recovery : A Narrative Review}, author = {Nilsson, Ulrica and Amirpour, Anahita and Lampi, Maria and Guenna Holmgren, Amina and Markovic, Gabriela and Zecevic, Ernad and Nömm, Marcus and Drakenberg, Anna and Claesson Lingehall, Helena and Damén, Tor and Martinik, Anna and Saarijärvi, Markus and Bergman, Lina and Eckerblad, Jeanette}, year = {2025}, journal = {Clinical Interventions in Aging}, volume = {20}, pages = {2579--2591}, doi = {10.2147/CIA.S559531}, url = {2024101}, language = {eng}, publisher = {Dove Medical Press}, keywords = {delayed neurocognitive recovery; next of kin; patient experiences; postoperative delirium; postoperative neurocognitive decline}, abstract = {Perioperative neurocognitive disorders, including postoperative delirium, delayed neurocognitive recovery and mild/major postoperative neurocognitive disorder, are common complications that affect older adults after surgery. Postoperative delirium, which occurs in 10-60% of major surgery patients, can increase the risk of delayed neurocognitive recovery and postoperative neurocognitive disorder, which affects 10-25% of patients. Preoperative and postoperative assessment of neurocognitive functioning typically involve the use of screening tools, such as Mini-Cog or 4AT. Despite the availability of evidence-based cognitive screening tools, many patients remain undiagnosed in clinical settings. Both postoperative delirium and postoperative neurocognitive disorder can lead to long-term cognitive and emotional complications, such as forgetfulness, trouble with initiating tasks, and mood disturbances. Next of kin experience considerable distress when witnessing delirium in a family member, a situation that is frequently exacerbated by a lack of information from health care professionals. Ethical challenges arise when cognitive impairment impacts patients' decision-making capacity, raising concerns about autonomy, use of restraints, and resource allocation. Informing patients about their risk of postoperative neurocognitive disorder before surgery is vital; however, it is not standardized in clinical practice. Further, there is a notable lack of interventions aimed at promoting neurocognitive recovery, with most guidelines relying on expert consensus. This narrative review therefore aims to explore recent advances in perioperative neurocognitive recovery, focusing on symptomatology, patient and next of kin experiences, assessments, care interventions and ethical aspects.}, issn = {1176-9092} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_urberglinnea_2025_2, title = {Om elevers motstånd i miljö- och hållbarhetsutbildning}, author = {Urberg, Linnea}, year = {2025}, url = {1967318}, language = {swe}, publisher = {Örebro University}, keywords = {resistance; environmental and sustainability education; counterculture; pluralism}, abstract = {This thesis explores students’ resistance to environmental and sustainability education (ESE) and how teachers can address resistance in their teaching. The thesis consists of four studies. The first is a study of tensions and resistance expressed on a youth internet forum. The study indicates that “sustainable development” appears economically, culturally, and socially conditioned for young people. The second and third studies are ethnographic and draw on theories of counterculture and resistance. Together, they offer a nuanced understanding of resistance, which is often inventive and meaningful while also carrying limitations. Resistance frequently gives rise to the laff — a liberating laugh that simultaneously entails something profoundly serious. The studies illuminate how students navigate prescribed requirements alongside cultural, social, and material conditions, where resistance may serve as an expression of distancing or feeling alienated by ESE. The students’ resistance exposes cracks in educational practice: environmental and sustainability education seeks to offer critical thinking and action competence, but it may, at the same time, be constrained by normative, social, and material conditions. The fourth study draws on teacher interviews and identifies three didactical strategies to address student resistance. A common aspect of these strategies is that they rely on the teachers’ didactic sensitivity, whereby teachers adopt a non-judgmental and pluralistic stance. The findings suggest that during fragile moments when resistance, meaningful content, and didactic sensitivity come together, the boundaries of pluralism become apparent and open to challenge.}, file = {https://oru.diva-portal.org/smash/get/diva2:1967318/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_huangbiying_2025, title = {Omental preservation versus omentectomy in curative-intent gastrectomy for gastric cancer : Swedish population-based cohort study}, author = {Huang, Biying and Kung, Chih-Han and Tsekrekos, Andrianos and Klevebro, Fredrik and Mayerhofer, Raphaela and Vossen Engblom, Laura and Lindblad, Mats and Hedberg, Jakob and Szabo, Eva and Edholm, David and Smedh, Ulrika and Johansson, Jan and Rouvelas, Ioannis and Nilsson, Magnus}, year = {2025}, journal = {BJS Open}, volume = {9}, number = {2}, doi = {10.1093/bjsopen/zraf012}, url = {1950756}, language = {eng}, publisher = {Oxford University Press}, abstract = {BACKGROUND: Omentectomy has traditionally been performed in gastric cancer surgery, but omental preservation has become increasingly common. It is unclear whether omentectomy leads to additional survival benefit compared with omental preservation. This nationwide population-based cohort study aimed to assess survival and surgical outcomes comparing omental preservation to omentectomy in curative-intent gastrectomy.METHODS: Patients were identified from the Swedish National Registry for Oesophageal and Gastric Cancer with inclusion between 2006 and 2022. The primary endpoint was overall survival assessed by a multivariable Cox proportional hazards model, adjusted for age, sex, American Society of Anesthesiologists physical status score, clinical T and N stage, type of gastrectomy, surgical approach, extent of lymphadenectomy, neoadjuvant chemotherapy, surgery year and regional cancer centre. Secondary endpoints were surgical outcomes including tumour-free resection margins, lymph node yield and postoperative complications.RESULTS: A total of 1615 patients were included, 517 (32.0%) underwent gastrectomy with omental preservation, and 1098 (68.0%) underwent gastrectomy with omentectomy. Overall survival after omental preservation was similar compared with omentectomy in the multivariable Cox model (HR 1.00, 95% c.i. 0.83 to 1.20; P = 0.967). Omental preservation also had similar surgical outcomes including lymph node yield and postoperative morbidity rate, compared with omentectomy.CONCLUSIONS: Omental preservation was similar to omentectomy in terms of overall survival and surgical outcomes. The results suggest that omentectomy can safely be omitted in curative-intent gastrectomy for gastric cancer.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_sofidana_2025_2, title = {(Om)formandet av socialtjänsten i sociala medier - diskurser och desinformation i ”LVU-kampanjen”}, author = {Sofi, Dana and Stier, Jonas and Wahlström, Emmie}, year = {2025}, pages = {265--275}, url = {2011983}, language = {swe}, publisher = {Södertörns högskola}, keywords = {desinformation; lvu-kampanjen; sociala medier; socialtjänsten; hyperreality} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_palmrsofia_2025, title = {Omission of postoperative radiotherapy after breast-conserving surgery in low-risk breast cancer}, author = {Palmér, Sofia and Valachis, Antonis and Lindman, Henrik and Smith, Daniel Robert and Wickberg, Åsa and Killander, Fredrika and Bjöhle, Judith and Einbeigi, Zakaria and Nilsson, Greger and Ahlgren, Johan and Villman, Kenneth}, year = {2025}, journal = {Journal of the National Cancer Institute}, volume = {117}, number = {6}, pages = {1125--1133}, doi = {10.1093/jnci/djae315}, url = {1921443}, language = {eng}, publisher = {Oxford University Press}, abstract = {BACKGROUND: This prospective cohort study aimed to assess whether postoperative radiotherapy could safely be omitted in women ≥ 65 years with low-risk, estrogen receptor (ER)-positive T1N0 breast cancer treated with breast-conserving surgery and adjuvant endocrine therapy.METHODS: Eligible patients were women ≥ 65 years with unifocal, non-lobular, grade 1 or 2, ER-positive, pT1N0 breast cancer treated with breast-conserving surgery and endocrine therapy for five years. Patients were followed up with mammography at least annually for 10 years. The primary endpoint was local recurrence. Secondary endpoints were contralateral breast cancer, recurrence-free survival, and overall survival.RESULTS: The final study cohort included 601 patients with a median age of 71 years (range: 65 to 90 years) and a median tumor size of 11 mm (range: 3 to 20 mm). Median follow-up time was 119 months (interquartile range: 103 to 121 months). The cumulative incidence of local recurrence was 1.5% (95% confidence interval (CI): 0.8 to 2.8%) and 5.5% (95% CI: 3.8 to 7.6%) at 5 and 10 years, respectively. The cumulative incidence of contralateral breast cancer was 1.7% (95% CI: 0.9 to 3.0%) at 5 years and 4.5% (95% CI: 3.0 to 6.6%) at 10 years. The overall survival rate at 10 years was 83.1% (95% CI: 80.8 to 85.4%). In total, three patients (0.5%) died due to breast cancer.CONCLUSION: Our results support the possibility to omit radiotherapy after breast-conserving surgery in a well-defined subgroup of women aged ≥ 65 years with low-risk, ER-positive, pT1N0 breast cancer receiving adjuvant endocrine therapy.}, issn = {0027-8874} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hugeliuskarin_2025, title = {Omvårdnad vid katastrofer och särskilda händelser}, author = {Hugelius, Karin}, year = {2025}, url = {1939171}, language = {swe} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_berghandreas_2025_1, title = {On collegial deliberation as a tool to counteract racism in education}, author = {Bergh, Andreas and Englund, Tomas}, year = {2025}, journal = {Education Inquiry}, volume = {16}, number = {1}, pages = {1--17}, doi = {10.1080/20004508.2022.2149088}, url = {1716964}, language = {eng}, publisher = {Routledge}, keywords = {teacher collaboration; collegial deliberation; deliberative communication; racism; sweden}, abstract = {This paper analyses and discusses the possibilities and challenges of collegial mutual deliberation among teachers as a way of counteracting racism. It takes its starting point in research on teacher collaboration that emphasises the importance of creating conditions locally for critical discussions, building on knowledge from different perspectives and going beyond simple solutions. With a focus on the practical, the idea of deliberative communication serves as a theoretical lens to analyse discussions among eight teachers on their responses to racism. The study provides theoretical and empirical knowledge about the potential contribution of collegial deliberation to developing a communicative teacher community that counteracts racism.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_jakobssonhugo_2025, title = {On fractures of the distal radius : outcome analysis, the role of socioeconomic factors and surgical considerations}, author = {Jakobsson, Hugo}, year = {2025}, url = {1931882}, language = {eng}, publisher = {Örebro University}, keywords = {distal radius fracture; volar locking plate; patient-reported outcome; socioeconomic factors; median nerve; nerve conduction study; pulp-to-palm distance}, abstract = {Distal radius fractures (DRFs) are the most common fractures, yet many patients experience suboptimal recovery. Radiological parameters and patient factors guide treatment decisions, and surgical treatment is aimed at restoring the anatomy. However, the radiological result correlates poorly with the outcome, and so other factors impactingt he outcome must be considered. The present thesis addresses this matter by investigating the outcome and factors potentially influencing the outcome, such as socioeconomic factors, decreased finger motion, and surgical technique. Using data from the Swedish Fracture Register (SFR) and prospectively collected data, four studies were conducted:• Study I: Analysed the epidemiology, treatment, and outcomes of intraarticular DRFs in the SFR.• Study II: Examined decreased finger motion in relation to outcomes in 140 patients.• Study III: Investigated the impact of socioeconomic factors on DRF recovery.• Study IV: Assessed the risk of median neuropathy associated with the volar central approach in a cohort of 38 patients.Key findings included the following: a considerable proportion of patients with intraarticular fractures experience disability 1 year after the fracture. Country of birth significantly affects DRF recovery, with non-European patients having higher risk of reported poor outcomes. Patients with decreased finger motion at 4 weeks post-surgery report worse outcomes up to 1 year after the surgery, suggesting its potential as a prognostic tool. The volar central approach carries a considerable risk of median neuropathy, and should be used only when optimal visualization of the distal radius is needed.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nilssonjakoba_2025, title = {On Having Ideas : Concepts, Thought Disciplines, and Media Form as Category Complication}, author = {Nilsson, Jakob A.}, year = {2025}, journal = {Deleuze and Guattari studies}, volume = {19}, number = {2}, pages = {176--180}, doi = {10.3366/dlgs.2025.0591}, url = {1986555}, language = {eng}, publisher = {Edinburgh University Press}, issn = {2398-9777} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fortepaolo_2025, title = {On Robust Context-Aware Navigation for Autonomous Ground Vehicles}, author = {Forte, Paolo and Gupta, Himanshu and Andreasson, Henrik and Köckemann, Uwe and Lilienthal, Achim J.}, year = {2025}, journal = {IEEE Robotics and Automation Letters}, volume = {10}, number = {2}, pages = {1449--1456}, doi = {10.1109/LRA.2024.3520920}, url = {1923502}, language = {eng}, publisher = {IEEE}, keywords = {autonomous vehicle navigation; motion and path planning; robotics and automation in construction}, abstract = {We propose a context-aware navigation framework designed to support the navigation of autonomous ground vehicles, including articulated ones. The proposed framework employs a behavior tree with novel nodes to manage the navigation tasks: planner and controller selections, path planning, path following, and recovery. It incorporates a weather detection system and configurable global path planning and controller strategy selectors implemented as behavior tree action nodes. These components are integrated into a sub-tree that supervises and manages available options and parameters for global planners and control strategies by evaluating map and real-time sensor data. The proposed approach offers three key benefits: overcoming the limitations of single planner strategies in challenging scenarios; ensuring efficient path planning by balancing between optimization and computational effort; and achieving smoother navigation by reducing path curvature and improving drivability. The performance of the proposed framework is analyzed empirically, and compared against state of the art navigation systems with single path planning strategies.}, file = {https://oru.diva-portal.org/smash/get/diva2:1923502/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kaddourayousef_2025, title = {On Robustness to Random Breaks in Panel Data}, author = {Kaddoura, Yousef and Westerlund, Joakim}, year = {2025}, journal = {Oxford Bulletin of Economics and Statistics}, doi = {10.1111/obes.70032}, url = {2027158}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {breakpoint estimation; panel data; parameter heterogeneity; random parameter model; structural break}, abstract = {One of the attractions of panel data is the ability to pool information regarding parameters that are common across the cross-section. In fact, pooling is standard even though there are often reasons to believe that parameters are not common. One reason for this practice is that there is quite some evidence to suggest that estimators of common parameters are robust to random heterogeneity, so much so that this type of robustness is sometimes taken for granted. In the present paper, we consider the problem of least squares estimation of the breakpoint in a panel data model with a breaking mean. This part of the literature standardly assumes that there is a common breakpoint, and all results available are based on this assumption. Yet, it is not difficult to find studies suggesting that the least squares breakpoint estimator should be robust to random heterogeneity. We show that it is not, except in special circumstances.}, issn = {0305-9049} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_2025_3, title = {On running a Professional Learning Community for ‘International Educators’ : Lessons from diverse perspectives}, year = {2025}, url = {2024759}, language = {eng}, publisher = {Örebro universitet}, abstract = {This paper explores the implementation and impact of Professional Learning Communities (PLCs) for international educators, with a particular focus on experiences at Örebro University (ORU) and its collaboration with Ostrava University (OU) and The Hague University of Applied Sciences (THUAS) in their “Triplet PLC”, situated in the context of a larger project on PLC’s. The study is situated within the broader context of internationalization in higher education, highlighting the unique challenges faced by educators working in increasingly diverse and multilingual environments.The first section details the rationale for establishing a PLC at ORU, emphasizing the need for pedagogical support among international educators. The PLC model, defined as a collaborative, reflective, and growth-oriented group, was adopted to address complex issues. The PLC operated through a blend of online cross-institutional sessions and informal local "fika" meetings, fostering both structured and organic professional development. Research on PLCs is reviewed, demonstrating their positive effects on teaching skills, collaborative learning, and trust-building among educators. The continuation of the paper delves into the reflections of the participants and facilitators of the PLC from ORU.The second section shows that the facilitators played a central role in organizing and steering the PLC. Five key aspects—relationship, space, ownership, direction, and result—are identified as critical to effective facilitation, with practical examples illustrating how these were embodied in the Triplet PLC. The third section explores the students’ perspectives on AI integration in higher education based on results from a survey conducted at the three “Triplet PLC” universities. The majority of respondents from all three countries are aware of AI technologies and use them in several ways: supporting writing, supporting research and learning, providing comprehensive explanations, getting inspiration, and improving efficiency. Furthermore, most students believe that AI is useful in higher education. In the fourth section, intercultural supervision is addressed as a distinct challenge. Key strategies include cultural awareness, clear communication, flexibility, empathy, and supportive feedback. The PLC provided a valuable platform for sharing experiences and developing best practices in this area. Exercises and recommendations for effective cross-cultural mentoring are presented.In the final section, the paper discusses the practical integration of PLC-derived materials and methods into a master’s program in Chemistry at ORU. Activities such as the "Value Game" and collaborative environmental discussions were introduced to promote intercultural understanding and inclusive teaching. The PLC experience led to concrete improvements in program design, collaboration, and emotional support among faculty and students. In conclusion, the paper demonstrates that PLCs are a powerful mechanism for professional development, fostering innovation, collaboration, and inclusivity in internationalized higher education settings. The diverse contributions and spin-off projects described reflect the transformative potential of PLCs, encouraging further experimentation and cross-disciplinary engagement.}, file = {https://oru.diva-portal.org/smash/get/diva2:2024759/FULLTEXT03.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_iannottamarco_2025_1, title = {On the Fly Adaptation of Behavior Tree-Based Policies through Reinforcement Learning}, author = {Iannotta, Marco and Stork, Johannes Andreas and Schaffernicht, Erik and Stoyanov, Todor}, year = {2025}, url = {2015656}, language = {eng}, publisher = {Springer} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_roumbanislambros_2025, title = {On the present-future impact of AI technologies on personnel selection and the exponential increase in meta-algorithmic judgments}, author = {Roumbanis, Lambros}, year = {2025}, journal = {Futures: The journal of policy, planning and futures studies}, volume = {166}, doi = {10.1016/j.futures.2025.103538}, url = {1926026}, language = {eng}, publisher = {Elsevier}, keywords = {human judgment and decision-making; hiring and personnel selection; expert recruiters; expectations and imagined futures; sociology of algorithms}, abstract = {The ongoing implementation of new AI technologies in both public and private organizations has already had a great impact on professional judgment and decision-making processes. For many experts working with people’s applications tied to, e.g., welfare services, employment, school admission, parole, and insurance, algorithm-based decision assistance has already changed the way they perform their assessments. Yet we are still in what seems to be the early stages of this socio-technological transformation. Based on interviews with twenty-four expert recruiters, the purpose of the study is to explore their professional views and expectations concerning the present-future impact of AI on personnel selection. The study seeks to shed new light on the exponential increase in meta-algorithmic judgments, a concept that pinpoints the fact that many experts today must handle algorithmic assessments before moving forward in the decision-making process. What do the respondents think has motivated this socio-technological change, and what do they expect will happen to the role of human judgment in the future? The analysis suggests that the seemingly inevitable existence of human biases and the lack of efficiency in traditional recruitment are, according to all respondents, the main reasons why AI should be used, given its promise to improve both fairness and time management. While AI recruitment systems will most likely become increasingly sophisticated, most respondents thought that these systems would nevertheless never be able to fully replace human judgment. However, a handful of respondents deviated from this majority vie}, issn = {0016-3287} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_qandeelmais_2025_4, title = {On the Way to Cyber Norms : Legal Frameworks and Human Rights}, author = {Qandeel, Mais and Cristiano, Fabio}, year = {2025}, pages = {167--183}, doi = {10.1007/978-3-031-93385-1_8}, url = {2009536}, language = {eng}, publisher = {Palgrave Macmillan}, keywords = {cyber norms; normative expectations; binding law requirements; international cybersecurity; human rights}, abstract = {The formation of cyber norms at the international level is a complex and evolving process that requires the coordinated efforts of cyber diplomats, legal experts, and policymakers. Key obstacles include the rapidly changing technological environment, rising technonationalisms, differing interpretations of international legal frameworks, and a fragmented normative landscape. This chapter outlines the intricate landscape of cyber norms formation. It does so by (i) retracing the crucial role of international law in this process by providing a framework for consensus and legitimacy; (ii) discussing the challenges cyber diplomats face in navigating the tension between normative expectations and binding law requirements; and (iii) exploring how this tension is manifested in the debate on the nexus between international cybersecurity and human rights across its fragmented normative landscape.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lainpeltojack_2025, title = {Once a low-status industry, always a low-status industry? - an analysis of the construction of labour market problems and the representation of restaurant work}, author = {Lainpelto, Jack and Wellton, Lotte}, year = {2025}, journal = {Scandinavian Journal of Hospitality and Tourism}, volume = {25}, number = {5}, pages = {417--432}, doi = {10.1080/15022250.2025.2593826}, url = {2026639}, language = {eng}, publisher = {Routledge}, keywords = {restaurant work; low status; vat; labour politics}, abstract = {The restaurant industry faces challenges with poor working conditions and low job status, making it difficult to recruit and retain staff. With this premise, this study examines how the concept of restaurant work is constructed within the restaurant industry and broader societal discourses by applying two Foucauldian analytical tools: the problem and the truth. The article's contextual starting point is the reduced VAT rate for restaurant and catering services in Sweden, which is implemented to combat unemployment and increase the flow of labour into the industry. The analysis reveals three key representations: the social entrepreneur, the entrepreneurial victimhood, and the frontline guardian of the moral economy. These representations highlight the restaurant industry's position in addressing unemployment and integration, while also emphasising the economic hardships faced by restaurant entrepreneurs. The study concludes that an entrenched link between low-status jobs and the restaurant industry is perpetuated by these representations, suggesting that investments in improved working conditions are considered to put the economic foundation of the restaurant industry at risk.}, issn = {1502-2250} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hllebergnymanmaria_2025_1, title = {One fracture is enough! : Support for implementation of a new care process}, author = {Hälleberg Nyman, Maria and Nilsagård, Ylva and Nilsing Strid, Emma and Fjordkvist, Erika}, year = {2025}, url = {1950037}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vandeynsehelena_2025, title = {One-year employment outcome prediction after traumatic brain injury : A CENTER-TBI study}, author = {Van Deynse, Helena and Cools, Wilfried and De Deken, Viktor-Jan and Depreitere, Bart and Hubloue, Ives and Tisseghem, Ellen and Putman, Koen}, year = {2025}, journal = {Disability and Health Journal}, volume = {18}, number = {2}, doi = {10.1016/j.dhjo.2024.101716}, url = {1909779}, language = {eng}, publisher = {Elsevier}, abstract = {BACKGROUND: Traumatic brain injury (TBI) can come with long term consequences for functional outcome that can complicate return to work. OBJECTIVES: This study aims to make accurate patient-specific predictions on one-year return to work after TBI using machine learning algorithms. Within this process, specific research questions were defined: 1 How can we make accurate predictions on employment outcome, and does this require follow-up data beyond hospitalization? 2 Which predictors are required to make accurate predictions? 3 Are predictions accurate enough for use in clinical practice?METHODS: This study used the core CENTER-TBI observational cohort dataset, collected across 18 European countries between 2014 and 2017. Hospitalized patients with sufficient follow-up data were selected for the current analysis (N = 586). Data regarding hospital stay and follow-up until three months post-injury were used to predict return to work after one year. Three distinct algorithms were used to predict employment outcomes: elastic net logistic regression, random forest and gradient boosting. Finally, a reduced model and corresponding ROC-curve was created.RESULTS: Full models without follow-up achieved an area under the curve (AUC) of about 81 %, which increased up to 88 % with follow-up data. A reduced model with five predictors achieved similar results with an AUC of 90 %.CONCLUSION: The addition of three-month follow-up data causes a notable increase in model performance. The reduced model - containing Glasgow Outcome Scale Extended, pre-injury job class, pre-injury employment status, length of stay and age - matched the predictive performance of the full models. Accurate predictions on post-TBI vocational outcomes contribute to realistic prognosis and goal setting, targeting the right interventions to the right patients.}, issn = {1936-6574} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mayrriedlermichaels_2025, title = {One-Year Quality of Life Outcomes of Delayed Unilateral Autologous Breast Reconstruction and Associated Patient Factors}, author = {Mayr-Riedler, Michael S. and Holm, Sebastian and Aristokleous, Iliana and de Vries, Bart and Rodriguez-Lorenzo, Andres and Riilas, Tua and Mani, Maria}, year = {2025}, journal = {JPRAS Open}, volume = {43}, pages = {56--66}, doi = {10.1016/j.jpra.2024.10.014}, url = {1920367}, language = {eng}, publisher = {Elsevier}, keywords = {autologous; breast reconstruction; breast-q; diep; prom}, abstract = {INTRODUCTION: As breast cancer survival rates improve, the long-term quality of life (QoL) has become increasingly important. With a significant number of patients still undergoing mastectomy and experiencing its well-known negative impacts on QoL, breast reconstruction aims to mitigate this by restoring body integrity. This study aimed to evaluate the changes in QoL and satisfaction in patients after breast reconstruction and influence of various patient-related factors.METHODS: Patients who underwent delayed unilateral deep inferior epigastric perforator (DIEP) breast reconstruction at a single institution between January 2016 and April 2019 were surveyed. QoL was assessed using the BREAST-Q questionnaire preoperatively and one year postoperatively. Scores were compared between the time points, and regression analysis was conducted to identify the influence of age, body mass index, economic status, education level, and relationship status on QoL.RESULTS: Among the 93 patients, 55 completed the preoperative and one-year postoperative BREAST-Q questionnaires (response rate: 59%). Postoperative QoL scores significantly increased for the domains "satisfaction with breasts," physical well-being chest," "sexual well-being," and "psychosocial well-being" (p<0.001). The scores for the domain "physical well-being abdomen" remained unchanged one year postoperatively. Higher education correlated with greater satisfaction with the breasts. Lack of an intimate partnership was identified as a significant negative factor for poorer psychosocial well-being.CONCLUSIONS: Delayed unilateral DIEP breast reconstruction significantly enhances QoL and breast satisfaction one year postoperatively without causing long-term physical discomfort at the donor site. Education level and relationship status significantly affect the postoperative outcomes. Tailored preoperative counseling and psychosocial support are essential to maximize patient satisfaction and well-being following reconstruction.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_larssonjohannes_2025_1, title = {Online emotion regulation treatment for maladaptive anger inhibition - an open-label pilot with a pooled interrupted time series design}, author = {Larsson, Johannes and Ojala, Olivia and Bjureberg, Johan and Sederström, Philip and Hvass, Oskar and Björk, Patrik and Lidskog, Samuel and Hesser, Hugo}, year = {2025}, journal = {Cognitive Behaviour Therapy}, doi = {10.1080/16506073.2025.2542355}, url = {1989238}, language = {eng}, publisher = {Routledge}, keywords = {anger; aggression; anger suppression; anger inhibition; emotion regulation}, abstract = {Despite documented risks associated with excessive anger inhibition, few treatments specifically target maladaptive anger inhibition. Building on a previously evaluated treatment for general anger, this study evaluated the feasibility, acceptability, and preliminary efficacy of a brief (4-week), therapist-supported online emotion-regulation treatment for maladaptive anger inhibition. In total 38 participants (89.5% female; M-age = 43.8, SD = 14.1) with elevated levels of maladaptive anger inhibition were offered treatment, which was evaluated using a pooled interrupted time series design (ITS). Treatment outcomes included measures of anger inhibition, anger rumination, and anger assertion that were assessed during a baseline phase (4 weeks) and a treatment phase (4 weeks). Feasibility was supported by high retention and adherence, and minor adverse events. Moreover, participants reported high treatment credibility and satisfaction, indicating good acceptability of the treatment. Piecewise growth curve analysis for ITS, comparing baseline and treatment phases, revealed significant and large immediate effects on all outcomes: anger inhibition (d = 1.26), anger rumination (d = 0.80), and anger assertion (d = 0.79), with small additional gains observed at 3-month follow-up. Taken together, the findings suggest that this brief online emotion-regulation treatment for maladaptive anger inhibition is feasible, acceptable, potentially effective, warranting further investigation in an RCT. ClinicalTrials.gov identifier: NCT06697587}, issn = {1650-6073} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_fortepaolo_2025_1, title = {Online Planning and Optimization of Material Flow for Autonomous Robots}, author = {Forte, Paolo}, year = {2025}, url = {1999898}, language = {eng}, publisher = {Örebro University}, abstract = {Task and Motion Planning (TAMP) involves jointly addressing high-level task sequencing and low-level geometric motion planning. While early approaches treated these layers independently, it became clear that tight integration is essential: plans that are valid symbolically may fail geometrically during execution. As autonomous robots are increasingly deployed in complex, unstructured environments, addressing the combined TAMP problem in challenging domains has gained a lot of interest. One such domain gaining attention ove rthe past decade involves granular materials. Granular materials like sand, soil ,and grains exhibit both solid-like and fluid-like behavior, making their interaction with robotic systems highly uncertain and difficult to predict. For instance, the quantity of material a robot can scoop or transport depends on numerous unpredictable factors. This introduces unique challenges for planning and execution, as traditional strategies often struggle to adapt to suc hdynamic conditions. In practice, dealing with granular materials often requires blending pre-computed plans with online feedback mechanisms to remain effective.To address these challenges, this thesis focuses on the Material Flow Planning Problem (MFPP), namely the problem of efficiently moving granular materials from one place to another. The MFPP lies at the intersection of symbolic reasoning and reliable real-world execution and requires addressing three core tasks: planning actions, navigating to target locations, and executing actions under uncertainty. This thesis proposes an integrated, multi-layered planning and execution framework to bridge abstraction levels, from symbolic to physical execution. Central to this is a formal definition of the MFPP that enables reasoning across symbolic and continuous domains. Based on this, this thesis introduces Athena, a hierarchical planning framework that combines symbolic planning with behavior trees for adaptive and fault-tolerant execution. In order to reach and manipulate the material within these planned tasks, this thesis introduces Navigo, a context-aware navigation system that dynamically selects path planning and control strategies based on real-time feedback from the environment (e.g., terrain, weather, and obstacles), enabling robust autonomous navigation in harsh conditions. Finally, this thesis introduces Atlantis, a modular, multi-layered simulation framework designed to test andiiievaluate planning and control strategies across varying levels of abstraction: from high-level task models to physics-based simulations and real-world trials. Atlantis supports systematic testing and development, helping close the gap between high-level AI planning and low-level robotic execution. Overall, this work offers a robust and adaptable approach to TAMP in domains involving granular materials, providing new methods for planning and execution for complex scenarios both in simulation and real-world applications.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sjblomkatja_2025, title = {Online Transdiagnostic Emotion Regulation Treatment for Adolescents With Mental Health Problems : A Randomized Clinical Trial}, author = {Sjöblom, Katja and Frankenstein, Katri and Klintwall, Lars and Nilbrink, Jannike and Zetterqvist, Maria and Hesser, Hugo and Hedman-Lagerlöf, Erik and Gross, James J. and Hellner, Clara and Bellander, Martin and Bjureberg, Johan}, year = {2025}, journal = {JAMA Network Open}, volume = {8}, number = {6}, doi = {10.1001/jamanetworkopen.2025.14871}, url = {1970098}, language = {eng}, publisher = {American Medical Association (AMA)}, abstract = {IMPORTANCE: Mental health problems are common during adolescence, but access to effective treatments is limited. Transdiagnostic treatments could address this treatment gap, but their feasibility, acceptability, and effectiveness remain unknown.OBJECTIVE: To test the feasibility and acceptability of an online emotion regulation treatment for adolescents with mental health problems and investigate the preliminary effects on clinical outcomes and the target mechanism, emotion regulation.DESIGN, SETTING, AND PARTICIPANTS: This single-blind randomized clinical trial was conducted between October 16, 2022, and July 28, 2023, in a primary care setting in Sweden. Participants in the intention-to-treat analysis were adolescents aged 12 to 17 years with mental health problems and their parents.INTERVENTION: Participants were randomized 1:1 to 6 weeks of therapist-guided online transdiagnostic emotion regulation treatment or an active control condition consisting of 6 weeks of online supportive treatment.MAIN OUTCOMES AND MEASURES: The primary outcomes were feasibility and acceptability measures, including consent rate, completion of assessments, adherence, credibility and expectancy ratings (Credibility/Expectancy Questionnaire), and treatment satisfaction (Client Satisfaction Questionnaire), immediately after treatment. Clinical outcomes, rated by blinded assessor, included global symptom severity and improvement, symptoms of depression and anxiety, global functioning, and emotion regulation.RESULTS: A total of 30 adolescents (mean [SD] age, 14.2 [1.48] years; 28 females [93%]) were randomized to experimental treatment (n = 15) or active control treatment (n = 15). The consent rate (30 of 37 eligible participants [81%]) and rate of assessment completion immediately after treatment (28 [93%]) were high. Adherence, credibility, expectancy, and satisfaction in both groups were adequate. Participation in the experimental condition, but not the control condition, was associated with large within-group reductions in symptom severity (effect size, 1.30; 95% CI, 0.73-1.86) and symptoms of anxiety and depression (Cohen d, 1.07; 95% CI, 0.37-1.84), improved global functioning (Cohen d, 1.26; 95% CI, 0.66-1.85), and reductions in maladaptive cognitive coping (Cohen d, 1.10; 95% CI, 0.52-1.70) immediately after treatment.CONCLUSION AND RELEVANCE: In this randomized clinical trial, a brief online transdiagnostic emotion regulation treatment targeting adolescents with mental health problems was found to be feasible, acceptable, and potentially efficacious in primary care and may increase treatment outreach and accessibility for this population.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05032547.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lundinperc_2025, title = {Only fair accuracy of the radiographic classification of adult proximal humeral fractures in the Swedish Fracture Register : a cohort analysis}, author = {Lundin, Per C. and Dettmer, Anne and Adolfsson, Lars and Sandquist, Sofia and Hallgren, Hanna C Björnsson}, year = {2025}, journal = {Injury}, volume = {56}, number = {8}, doi = {10.1016/j.injury.2025.112558}, url = {1983528}, language = {eng}, publisher = {Elsevier}, keywords = {accuracy; classification; proximal humeral fracture; register; trauma}, abstract = {INTRODUCTION: Quality registers are used for quality assessment, cost analyses, and research regarding outcomes of surgical and non-operative treatments. As the Swedish Fracture Register (SFR) expands, and is used as a platform for randomized trials, assuring reliability and accuracy of the data is essential. AIM: This study aimed to investigate the accuracy of the radiographic classification data for proximal humerus fractures recorded in the SFR.METHOD: All radiographic images of 171 patients with a proximal humerus fracture registered in the SFR between 2019 and 03-01 and 2019-08-31 at 3 hospitals were included. The radiographs were independently assessed at 2 occasions >3 weeks apart by 1 surgeon at each center and IRR was calculated to validate the modification of the AO/OTA classification used in the register. A "gold standard" classification for each patients' images was then established with a consensus discussion involving 4 shoulder surgeons. The gold standard classification was compared with the classification registered in the SFR.RESULTS: Intra-rater reliability was moderate (kappa 0.549-0.596) with percent agreement (PA) 61-66 %. Inter-rater reliability was also moderate (kappa 0.508-0.557) with PA 58-62 %. Accuracy of the SFR recordings compared with gold standard was fair with kappa 0.36 (95 % CI 0.297-0.425) and PA 44 %.CONCLUSION: For registers to be of use the accuracy of data is essential as well as coverage, completeness, validity and reliability. The modified AO/OTA classification for proximal humerus fractures used in the SFR had moderate reliability but registered data only fair accuracy compared with a gold standard. This questions its value as a base for scientific research and clinical decisions.}, issn = {0020-1383} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lundinerik_2025, title = {Open or closed : a prospective, self-controlled study of the performance of two immobilisation mask types in head and neck cancer radiotherapy}, author = {Lundin, Erik and Granlund, Ulf and Thunberg, Per and Ahlgren, Johan}, year = {2025}, journal = {Radiotherapy and Oncology}, volume = {206}, number = {Suppl. 1}, pages = {S3105--S3106}, doi = {10.1016/S0167-8140(25)00443-8}, url = {1986295}, language = {eng}, publisher = {Elsevier}, keywords = {mask; immobilisation}, issn = {0167-8140} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lundinerik_2025_1, title = {Open or closed : Experience of head and neck radiotherapy masks - A mixed-methods study}, author = {Lundin, Erik and Axelsson, Sofia and Ohlsson-Nevo, Emma}, year = {2025}, journal = {Journal of Medical Radiation Sciences}, volume = {72}, number = {1}, pages = {74--84}, doi = {10.1002/jmrs.825}, url = {1901747}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {anxiety disorders; head and neck neoplasms; quality of life; radiation equipment and supplies; radiotherapy}, abstract = {INTRODUCTION: In radiotherapy for head and neck cancer, a mask is used to immobilise the head and shoulders. An open mask that does not cover the face is expected to cause less anxiety, but there is need to further investigate the patients' experience of open versus closed masks. Therefore, the aim of this study is to evaluate patient preferences for open or closed masks and whether an open mask can reduce discomfort and anxiety for patients.METHODS: Twenty participants were treated in alternating weeks using open and closed masks. Their distress was evaluated through semi-structured interviews and patient-reported outcome measures.RESULTS: When using the open mask, it took longer to position the patient correctly. The closed mask felt more confining and could induce a sense of claustrophobia. Participants employed both internal and external strategies to cope with the stressful situation. The Hospital Anxiety and Depression Scale (HADS) showed a significant reduction in anxiety over time during the treatment period, but no significant difference between the masks. When participants chose which mask to use for the final treatments, 12 chose the open mask, while 8 chose the closed mask. In addition to the 20 analysed participants, two participants withdrew from the study because they could only tolerate the open mask, one due to anxiety and the other due to swelling.CONCLUSIONS: The open mask seems to provide a less confined experience but may lead to greater difficulties in achieving the correct treatment position. While both masks can be viable options for most patients, some cannot tolerate closed masks but do tolerate open masks.}, issn = {2051-3895} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_muderdaniel_2025, title = {Operation time and outcomes in distal radius fracture fixation : a retrospective analysis of single- vs. dual-surgeon procedures in 163 cases}, author = {Muder, Daniel and Sagerfors, Marcus and Reiser, Daniel}, year = {2025}, journal = {BMC Musculoskeletal Disorders}, volume = {26}, number = {1}, doi = {10.1186/s12891-025-09359-4}, url = {2016836}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {distal radius fracture; operation time; operative treatment; surgical efficiency}, abstract = {BACKGROUND: Distal radius fractures (DRFs) are among the most common orthopedic injuries requiring surgical intervention. Understanding whether single- or dual-surgeon setting correlates to operation time, radiological results, or complication rates is essential for optimizing resource allocation and training strategies in clinical settings.METHODS: All DRFs treated operatively with volar plate fixation in 2023 were included in the study. Data were collected on the number of surgeons involved in each procedure and their respective levels of experience. These variables were analyzed in relation to operative time, radiological outcomes, postoperative complications, and AO classification.RESULTS: The study cohort included 163 operatively-treated DRFs with a mean follow-up of 15 months (range: 9-20). The most common fracture types were AO types A (n = 80, 49%) and C (n = 80, 49%). Of all procedures, 45% (n = 73) were performed by a single surgeon, while 55% (n = 90) involved two surgeons. Operative time was significantly shorter when surgeries were performed by a single surgeon. Radiological outcomes and complication rates did not differ significantly based on the number of surgeons involved, irrespective of their experience level. When less experienced surgeons were excluded and only more complex fractures were analyzed, the trend toward shorter operative time with a single surgeon persisted, though the difference did not reach statistical significance.CONCLUSIONS: The involvement of two surgeons does not necessarily correlate to operative time in the treatment of DRFs. Furthermore, radiological outcomes and complication rates appear unaffected by the number of surgeons. These findings may support more efficient allocation of surgical resources in hospital settings. The impact and importance of teaching and training in this context warrants further investigation.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_holymarek_2025, title = {Operative Treatment of Cervical Radiculopathy : A Comparison of Anterior Cervical Decompression and Fusion and Posterior Foraminotomy}, author = {Holy, Marek}, year = {2025}, url = {1944251}, language = {eng}, publisher = {Örebro University}, abstract = {Cervical radiculopathy is the most frequent condition of the cervical spine. Operative treatment is a commonly performed when nonsurgical treatment fails. The main cause of cervical radiculopathy is degenerative disease of the spine, leading to foraminal stenosis and ultimately a nerve-root impingement. Often patients ask about the heredity of their condition, but no clear answers can be given. The controversy is in the choice of operative treatment, conducting either Anterior Cervical Decompression and Fusion (ACDF) or Posterior Foraminotomy (PF). Both methods have been around since the late 1950’s but despite this, evidence is still lacking to confirm superiority of either method. The objective of this thesis is to ascertain the outcomes of ACDF and PF as well as the hereditary factors for requiring surgery. We used the Swespine registry to ascertain the clinical outcomes of surgery for CR, subsequently, by using pseudo-randomization we evaluated the patient reported outcomes and reoperation rates between ACDF and PF. Our results revealed that both methods have equal clinical outcomes at 1,2- and 5-years of follow-up. We showed higher reoperation rate for PF than ACDF at index level. Subsequently, we could move forward in creating a multicentre randomized controlled trial with ACDF as control, and PF as intervention with a non-inferiority design. A study protocol was designed using the reporting guidelines for clinical trials and published. Thus, Örebro Multicentre Study on Operative Treatment of Cervical Radiculopathy: Anterior Cervical Decompression and Fusion Versus Posterior Foraminotomy (OMSAP) was born and the study started in 2020. Interim analysis after 5-years of recruiting concludes higher reoperation rates for PF and statistically non-significant outcomes in favour of ACDF, no severe adverse events have been found in the analysis. Finally, we used the Swespine registry and the Twin registry to ascertain the hereditary factors for the surgical phenotype by examining the operation rates in 145 twins for cervical degenerative diseases. We conclude that the probability for hereditary factor for surgically treated diseases is low.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hokynkovalica_2025, title = {Opinion : Defining Readiness for Reconstructive Surgery in Patients With Advanced Pressure Ulcers-A Policy and Clinical Perspective}, author = {Hokynková, Alica and Šín, Petr and Beeckman, Dimitri and Váňa, Vladimír and Paulová, Hana and Pokorná, Andrea}, year = {2025}, journal = {Wound Repair and Regeneration}, volume = {33}, number = {5}, doi = {10.1111/wrr.70099}, url = {2004614}, language = {eng}, publisher = {John Wiley & Sons}, issn = {1067-1927} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_petterssonmiriam_2025, title = {Opinions on the cost-effectiveness of home phototherapy}, author = {Pettersson, Miriam and Ryen, Linda and Eriksson, Mats and Ohlin, Andreas}, year = {2025}, journal = {Pediatric Research}, doi = {10.1038/s41390-025-04658-x}, url = {2018479}, language = {eng}, publisher = {Springer Nature}, keywords = {photo-therapy; health economics; newborn jaundice}, issn = {0031-3998} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_diwansalwan_2025_1, title = {Opioid-Free Anesthesia in Perioperative Care : Findings From a Swedish Web-Based Survey}, author = {Diwan, Salwan and Olausson, Alexander and Andréll, Paulin and Wolf, Axel and Jildenstål, Pether}, year = {2025}, journal = {Pain Research & Management}, volume = {2025}, doi = {10.1155/prm/6677904}, url = {2018085}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {attitudes; healthcare professionals; knowledge; opioid-free anesthesia; practices; web-based survey}, abstract = {OBJECTIVES: Opioid-free anesthesia (OFA) is a promising alternative to traditional opioid-based anesthesia. Research indicates that OFA reduces postoperative opioid consumption and related adverse effects while maintaining effective pain control and patient safety. Despite these benefits, clinical adoption of OFA remains limited, possible due to gaps in evidence. To bridge this knowledge gap, a web-based survey was used to assess Swedish healthcare professionals' (HCPs') knowledge, attitudes, and practices regarding OFA, aiming to identify barriers and facilitators for its broader integration into routine anesthesia care.METHODS: A web-based survey was sent to anesthesiology department heads at all university hospitals in Sweden and three randomly selected smaller hospitals. The department heads distributed the survey to anesthesiologists, nurse anesthetists, critical care nurses, and registered nurses involved in intraoperative care. The questionnaire had four sections: demographic data, general questions regarding intraoperative care, specific questions on OFA usage, and an open-ended question.RESULTS: A total of 309 HCPs responded to the survey, corresponding to a response rate of 35%. The majority of respondents (77%) had seven or more years of perioperative experience, 63% were female, and 82% worked at university hospitals. Knowledge about OFA was generally low, with 62% reporting insufficient knowledge, and 14% actively applied OFA. Self-report data demonstrated that anesthesiologists had significantly lower knowledge levels on applying OFA compared to nurse anesthetists and critical care nurses (p < 0.01). However, 85% of all HCPs expressed interest in acquiring additional theoretical knowledge about OFA. Additionally, 87% reported either absent guidelines or uncertainty about their existence, while most (57%) agreed that guidelines supporting the practice of OFA should be introduced at their clinic.CONCLUSION: This survey indicated interest in OFA among Swedish perioperative HCPs while revealing key barriers to implementation, including knowledge gaps and limited guidelines. Addressing these challenges through targeted education and institutional support may facilitate broader OFA adoption, enhancing patient safety and multimodal perioperative pain management.}, issn = {1203-6765} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kinoshitamari_2025, title = {Opioids in Procedural Pain in Newborns}, author = {Kinoshita, Mari and Olsson, Emma and Borys, Franciszek and Bruschettini, Matteo}, year = {2025}, journal = {Anesthésie & Réanimation}, volume = {11}, number = {2}, pages = {171--173}, doi = {10.1016/j.anrea.2025.04.002}, url = {1963394}, language = {eng}, publisher = {Elsevier}, issn = {2352-5800} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kofodlinettemarie_2025_1, title = {Optimised oxygenation improves functional capacity during daily activities in patients with COPD on long-term oxygen therapy : a randomised crossover trial}, author = {Kofod, Linette Marie and Hansen, Ejvind Frausing and Brocki, Barbara Christina and Kristensen, Morten Tange and Roberts, Nassim Bazeghi and Westerdahl, Elisabeth}, year = {2025}, journal = {Thorax}, volume = {80}, number = {11}, pages = {803--809}, doi = {10.1136/thorax-2024-221883}, url = {1969987}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {copd pathology; exercise; hypoxemia; long term oxygen therapy (ltot); pulmonary rehabilitation}, abstract = {BACKGROUND: Minimising hypoxaemia during submaximal walking tests has a positive effect on exercise capacity and dyspnoea in patients with chronic obstructive pulmonary disease (COPD) on long-term oxygen therapy (LTOT). However, the impact of optimising oxygenation during everyday tasks remains unexplored. Therefore, we investigated the effects of maintaining a target saturation on activities of daily living (ADL) using automated oxygen titration compared with conventional fixed oxygen flow.METHODS: In a double-blinded, randomised crossover trial, patients with COPD on LTOT performed two GlittreADL tests to assess the functional capacity of everyday activities using (1) their fixed oxygen dose and (2) an adjusted flow from 0 to 8 L/min targeting a peripheral oxygen saturation (SpO2) of 90-94%. A closed-loop device automatically titrated the oxygen based on information from a Bluetooth wrist pulse oximeter.RESULTS: 31 patients (mean±SD age: 72.8±5.9 years, forced expiratory volume in 1 s of % predicted: 36.7±12.7) were included. The patients reduced the time to perform the ADL test by median (IQR) 38 (12-73) s, p<0.001, using automated titration compared with the fixed oxygen flow. The oxygen flow in the automated arm more than tripled to 5.4 (4.1-6.8) versus 1.6 (1.1-2.1) L/min (fixed) during the test, p<0.001, while the time spent within SpO2-target was increased from 19% to 49%, p=0.002. Correspondingly, the patients experienced less dyspnoea (BorgCR10); 5 (3-7) versus 6 (4-8), p<0.001, in favour of the automated oxygen titration.CONCLUSIONS: Improving oxygenation and extending the time spent within target saturation reduced dyspnoea and improved functional capacity in ADL in patients with COPD on LTOT.TRIAL REGISTRATION NUMBER: NCT05553847.}, issn = {0040-6376} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kjllquistuna_2025, title = {Optimization of guidelines for Risk Of Recurrence/Prosigna testing using a machine learning model : a Swedish multicenter study}, author = {Kjällquist, Una and Tsiknakis, Nikos and Acs, Balazs and Margolin, Sara and Kessler, Luisa Edman and Levy, Scarlett and Ekholm, Maria and Lundgren, Christine and Olsson, Erik and Lindman, Henrik and Valachis, Antonios and Hartman, Johan and Foukakis, Theodoros and Matikas, Alexios}, year = {2025}, journal = {The Breast}, volume = {82}, doi = {10.1016/j.breast.2025.104489}, url = {1957673}, language = {eng}, publisher = {Elsevier}, keywords = {adjuvant; breast cancer; machine learning; prosigna; risk of recurrence}, abstract = {PURPOSE: Gene expression profiles are used for decision making in the adjuvant setting in hormone receptor-positive, HER2-negative (HR+/HER2-) breast cancer. While algorithms to optimize testing exist for RS/Oncotype Dx, no such efforts have focused on ROR/Prosigna. This study aims to enhance pre-selection of patients for testing using machine learning.METHODS: We included 348 postmenopausal women with resected HR+/HER2-node-negative breast cancer tested with ROR/Prosigna across four Swedish regions. We developed a machine learning model using simple prognostic factors (size, progesterone receptor expression, grade, and Ki67) to predict ROR/Prosigna output and compared the performance regarding over- and undertreatment with commonly employed risk stratification schemes.RESULTS: Previous classifications resulted in significant undertreatment or large intermediate groups needing gene expression profiling. The machine learning model achieved AUC under ROC of 0.77 in training and 0.83 in validation cohorts for prediction of indication for adjuvant chemotherapy according to ROR/Prosigna. By setting and validating upper and lower cut-offs corresponding to low, intermediate and high-risk disease, we improved risk stratification accuracy and reduced the proportion of patients needing ROR/Prosigna testing compared to current risk stratification.CONCLUSION: Machine learning algorithms can enhance patient selection for gene expression profiling, though further external validation is needed.}, issn = {0960-9776} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_latifsara_2025, title = {Optimizing agricultural health using a compact convolutional transformer model for plant disease detection}, author = {Latif, Sara and Mastoi, Qurat-ul-ain and Almujally, Nouf Abdullah and Alnazzawi, Noha and Hanif, Muhammad and Latif, Shahid}, year = {2025}, journal = {CABI Agriculture and Bioscience}, volume = {6}, number = {1}, doi = {10.1079/ab.2025.0083}, url = {2022822}, language = {eng}, publisher = {CABI Publishing}, keywords = {compact convolutional transformer; convolutional neural network; plant disease; vision transformer}, abstract = {Introduction: Plant diseases present a significant global challenge to agricultural productivity and food security, necessitating efficient and accurate detection methods. Traditional convolutional neural networks (CNNs) often struggle to capture long-range dependencies and global contextual information, while vision transformers (ViTs) require substantial computational resources, limiting their practicality in resource-constrained environments.Methods: This article introduces a compact convolutional transformer (CCT) model that effectively combines the local feature extraction capabilities of CNNs with the global contextual understanding of transformers. The proposed architecture employs a convolutional tokenization stage to generate semantically rich patches, followed by a lightweight transformer encoder that models complex spatial relationships essential for fine-grained disease recognition.Results: Extensive experiments on a new plant disease dataset demonstrate the superior performance of the proposed framework, achieving an overall accuracy of 93.55%. The model also exhibits remarkable efficiency, with a compact size of 16.66 MB and an inference time of 0.7 ms per image, making it suitable for edge deployment.Conclusion: Experimental outcomes significantly outperform existing state-of-the-art methods, highlighting the potential of the proposed CCT-based framework for real-world, scalable plant disease diagnosis in diverse agricultural settings.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_davidssonsabina_2025, title = {Optimizing Tissue Sampling Timing for Accurate Gene Expression Analysis}, author = {Davidsson, Sabina and Jerlström, Tomas and Carlsson, Jessica}, year = {2025}, journal = {International Journal of Molecular Sciences}, volume = {26}, number = {17}, doi = {10.3390/ijms26178581}, url = {1997782}, language = {eng}, publisher = {MDPI}, keywords = {gene expression; tissue sampling timing; urinary bladder}, abstract = {The reliability of molecular diagnostic and prognostic tools is contingent on the quality of biospecimens, which are often collected during surgical procedures. This study investigated the impact of surgical manipulation on gene expression in the urinary bladder mucosa during radical cystectomy. Seventeen patients with urinary bladder cancer were enrolled, and paired pre- and post-surgery biopsies were analyzed. Pre-surgical biopsies were obtained in situ under anesthesia, while post-surgical biopsies were collected ex vivo following bladder removal. Total RNA was extracted, and gene expression was assessed using qPCR arrays, measuring the expression of 374 inflammation-related genes. The findings from the exploratory phase were further validated by analyzing key genes in an independent patient cohort using TaqMan® gene-specific assays. Exploratory analysis revealed significant differential expression in 27 genes, with key genes such as IL6, FOS, and PTGS2 being upregulated post-surgery. Validation of five selected genes in an independent cohort confirmed these findings. This study reinforces the necessity of accounting for surgery-induced alterations in gene expression when analyzing tissue samples collected intraoperatively. By elucidating the molecular impact of surgical interventions, this work provides critical insights for refining experimental methodologies and enhancing the interpretability of gene expression studies in clinical and research settings.}, issn = {1661-6596} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lagerbergtyra_2025, title = {Oral glucocorticoids and risk of psychiatric and suicidal behaviour outcomes : population-based cohort study}, author = {Lagerberg, Tyra and Gustafsson, Tapio T. and Molero, Yasmina and Forton, Julian and Sariaslan, Amir and Chang, Zheng and Larsson, Henrik and Lichtenstein, Paul and Fazel, Seena}, year = {2025}, journal = {British Journal of Psychiatry}, doi = {10.1192/bjp.2025.128}, url = {1977009}, language = {eng}, publisher = {Royal College of Psychiatry}, keywords = {bipolar disorder; corticosteroid; depression; pharmacoepidemiology; suicidal behaviour}, abstract = {BACKGROUND: Despite evidence of associations between glucocorticoid treatment and adverse psychiatric and suicidal behaviour outcomes, large-scale observational evidence for serious outcomes is lacking. AIMS: To assess the risk of psychiatric and suicidal behaviour outcomes during glucocorticoid treatment.METHOD: Using Swedish population registers, we identified 1 105 964 individuals aged 15-54 years who collected a glucocorticoid prescription in oral form between 2006 and 2020. We investigated associations with a range of psychiatric outcomes: unplanned specialist healthcare contacts due to depressive, bipolar, anxiety or schizophrenia-spectrum disorders; and deaths by suicide or unplanned specialist healthcare contacts due to self-harm ('suicidal behaviour'). We estimated hazard ratios from Cox proportional hazards models in a medication-only cohort by comparing outcome rates during and outside treated periods within individuals. We further identified individuals with an autoimmune or gastrointestinal autoimmune disorder diagnosis and compared hazards of the outcomes between those who did and did not initiate a glucocorticoid using a target trial emulation approach.RESULTS: We found increased risks for psychiatric outcomes, with within-individual hazard ratios ranging from 1.08 (95% CI, 1.00-1.16) for depressive disorders to 1.23 (95% CI, 1.12-1.36) for bipolar disorder and 1.25 (95% CI, 1.20-1.31) for anxiety disorders. We found no clear association with suicidal behaviour (hazard ratio: 1.06; 95% CI, 0.96-1.17). These findings were similar when stratified by age and gender. Within-individual associations were attenuated in those diagnosed with an autoimmune disorder. The risk of anxiety and bipolar disorder outcomes appeared particularly elevated in the first weeks of treatment. Absolute rates were modestly elevated during treatment, and higher in those with a history of psychiatric disorders.CONCLUSIONS: Glucocorticoid treatment is associated with elevated risks of serious psychiatric outcomes, including the onset and relapse of common psychiatric disorders. Individuals with psychiatric histories may require additional monitoring during glucocorticoid treatment.}, issn = {0007-1250} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_johnstoneleanne_2025_5, title = {Organisational and individual accountability for sustainability through control}, author = {Johnstone, Leanne}, year = {2025}, pages = {273--297}, doi = {10.4018/979-8-3693-5663-0.ch012}, url = {1885786}, language = {eng}, publisher = {IGI Global}, abstract = {This chapter elaborates on the connections between organisational and individual-level accountabilities for sustainability control purposes. This aim is achieved through a conceptual study that draws on accountability as the theoretical lens and some recent sustainability control works in different contexts to highlight potential research avenues for scholars conducting research into sustainability management, accounting, and/or control. The chapter finds that building on the individual level of accountability and socialising accountability form is important to incorporate into sustainability control studies given that such research is often conceptualised at the organisational level of external accounts. For practitioners, the chapter suggests that formalised control system design is not enough to ensure that sustainable performance outcomes are achieved in practice, and that managers in different types of organisational forms should integrate the views, perspectives, and beliefs systems of other (non-managerial) employees into their daily sustainability work.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sonerydlinda_2025, title = {Organising for Social Sustainability in Urban Housing : Hitting the Target but Missing the Point}, author = {Soneryd, Linda and Bogdanova, Elena and Grinderslev, Thomas}, year = {2025}, journal = {Journal of Organizational Sociology}, volume = {3}, number = {3}, pages = {377--397}, doi = {10.1515/joso-2024-0007}, url = {2008818}, language = {eng}, publisher = {Walter de Gruyter}, keywords = {social sustainability; housing; processes of translation}, abstract = {Social sustainability has become a widely known term, not least in the area of housing and urban development. While the literature has improved our understanding of the various meanings and interpretations of the concept, there is still a need for studies that explore processes of organising for social sustainability as processes of translation that can take into consideration several dimensions of translation, i.e. shifts in meaning, as well as agency and interests. This paper aims to address this issue-complex by exploring how social sustainability is conceived and translated into practice in urban renovation projects. The contribution of our analysis is that we show how resources within organizational theory and research can contribute to a more general understanding of how popular but vague concepts are or are not transformed into action and the implications of this.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_hearnjeff_2025_5, title = {Organizing collaboratively in feminist-gender academia : An auto-dialogue on dilemmas, delights, and disillusions}, author = {Hearn, Jeff}, year = {2025}, pages = {77--88}, doi = {10.1007/978-3-658-46935-1_6}, url = {1998329}, language = {eng}, publisher = {Springer VS Verlag}, keywords = {collaboration; organizing; higher education; feminist-gender; academia}, abstract = {Collaboration is a central activity in and around academia. This is especially so in feminist-gender research, teaching and development. However, the collaborative impulse within feminisms can be in tension with some of the conditions of contemporary academia. The neoliberalization of universities, academia, and science has changed the structural, organizational and working conditions within which academic collaboration takes place. This can lead onto ambiguous, hybrid contexts for feminist-gender academic work. In the spirit of collaboration, this auto-dialogue interrogates collaboration in feminist-gender academia, in the light of personal and collective experience, with emphasis on dilemmas, delights and disillusions – as part of the critical and feminist task.}, file = {https://oru.diva-portal.org/smash/get/diva2:1998329/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hokynkovalica_2025_1, title = {Osseous Involvement in Advanced Pressure Ulcers : Expert Insights Into Classification Challenges and Clinical Implications}, author = {Hokynková, Alica and Šín, Petr and Beeckman, Dimitri and Repko, Martin and Pokorná, Andrea}, year = {2025}, journal = {International Wound Journal}, volume = {22}, number = {8}, doi = {10.1111/iwj.70722}, url = {1989835}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, issn = {1742-4801} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gillvingcecilia_2025, title = {Outcomes of ECT for depression in patients with and without eating disorders}, author = {Gillving, Cecilia and Arnison, Tor and Nordenskjöld, Axel}, year = {2025}, journal = {Journal of Psychiatric Research}, volume = {183}, pages = {308--312}, doi = {10.1016/j.jpsychires.2025.02.042}, url = {1939482}, language = {eng}, publisher = {Elsevier}, keywords = {eating disorders; major depressive disorder; electroconvulsive therapy; anorexia nervosa; antidepressants}, abstract = {Eating disorders (ED) have a high comorbidity with major depressive disorder (MDD). Antidepressants often lack effect in these patients. While electroconvulsive therapy (ECT) is the most effective treatment for severe MDD, there are no large studies in the ED patient group yet. We aimed to compare the outcome of ECT for MDD in patients with and without eating disorders. We conducted a register-based study for patients with MDD and comorbid ED treated with ECT in Sweden between 2012-2023. The outcomes were compared to a matched control group without comorbid ED. The primary outcome was a response to treatment according to the Clinical Global Impression Improvement Scale (CGI-I). Secondary outcomes were remission according to CGI-I and subjective memory complaint. There were 861 patients in the ED group and 1,722 in the control group; of these 93.2% were female. The response rate was 58.4% in the ED group and 62.4% in the control group (OR 0.8, 95% CI 0.7-0.9, p <0.05). The frequency of subjective memory complaints in the ED versus the control group was 25.9% and 24.8%, respectively (OR 1.1, 95% 0.8-1.3 CI, p = 0.6). High response rates after ECT for MDD were found in the ED group but were significantly lower than in the matched control group. Subjective memory complaints did not differ significantly. Further studies are required comparing the outcome of ECT versus alternative treatments among patients with ED complicated by severe MDD.}, issn = {0022-3956} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stenbergerik_2025_1, title = {Outcomes of inflammatory bowel disease in patients with obesity following bariatric surgery : propensity score-matched cohort study}, author = {Stenberg, Erik and Everhov, Åsa H. and Söderling, Jonas and Ottosson, Johan and Osooli, Mehdi and Andersson, Ellen and Bergemalm, Daniel and Ludvigsson, Jonas F. and Eriksson, Carl and Olén, Ola}, year = {2025}, journal = {BJS Open}, volume = {9}, number = {4}, doi = {10.1093/bjsopen/zraf086}, url = {1990461}, language = {eng}, publisher = {Oxford University Press}, abstract = {BACKGROUND: Obesity is increasing among patients with inflammatory bowel disease, but bariatric surgery has been rare in this group owing to concerns about worsening the inflammatory bowel disease. The aim of the study was to evaluate inflammatory bowel disease-related outcomes following bariatric surgery.METHODS: Nationwide cohort of all adult patients in Sweden between 2007 and 2020 with obesity and inflammatory bowel disease. Patients were matched 1 : 1 with a two-stage matching process between those undergoing bariatric surgery with those who did not (classified by inflammatory bowel disease subtype followed by a propensity score match including sex, age, number of previous targeted therapies, presence of immunotherapy, cumulative oral corticosteroid dose, and previous intestinal surgery). The primary composite outcome comprised inflammatory bowel disease-related hospitalization, initiation of corticosteroid therapy, immunomodulation, commencement of a new targeted therapy or major inflammatory bowel disease-related surgery.RESULTS: The study included 798 patients with inflammatory bowel disease and obesity: 399 who underwent bariatric surgery (145 Crohn's disease, 238 ulcerative colitis, 16 unclassified inflammatory bowel disease) versus 399 who did not. Over a median observation period of 3.3 years in the surgery group and 3.0 years in the non-surgery group, the composite primary endpoint occurred in 201 patients who had surgery (incidence rate 11.9 (95% confidence interval (c.i.) 10.2 to 13.5) per 100 person-years) and 226 without surgery (incidence rate 15.1 (13.1 to 17.0) per 100 person-years), corresponding to an adjusted hazard ratio of 0.66 (95% c.i. 0.51 to 0.85) in those undergoing bariatric surgery compared with those who did not.CONCLUSION: Bariatric surgery was associated with improved inflammatory bowel disease-related outcomes among patients with inflammatory bowel disease and obesity, suggesting a potential benefit from bariatric surgery among patients with concomitant obesity and inflammatory bowel disease.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisioannis_2025_9, title = {Outcomes of patients with systemic lupus erythematosus treated with belimumab : a post hoc efficacy analysis of five phase III clinical trials by British Isles Lupus Assessment Group-based Combined Lupus Assessment criteria}, author = {Parodis, Ioannis and Lindblom, Julius and Palazzo, Leonardo and Cetrez, Nursen and Oon, Shereen and Ala, Henri and van Vollenhoven, Ronald F. and Morand, Eric and Levitsky, Adrian and Nikpour, Mandana}, year = {2025}, journal = {RMD Open}, volume = {11}, number = {2}, doi = {10.1136/rmdopen-2025-005444}, url = {1954820}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {biological therapy; lupus erythematosus; systemic; outcome assessment; health care; systemic lupus erythematosus}, abstract = {OBJECTIVES: To determine belimumab efficacy assessed using the British Isles Lupus Assessment Group (BILAG)-based Combined Lupus Assessment (BICLA) in patients with systemic lupus erythematosus (SLE) from phase III belimumab randomised controlled trials (RCTs).METHODS: A post hoc analysis was carried out on five RCTs in active adult SLE: four with intravenous (BLISS-52, BLISS-76, BLISS-NEA, EMBRACE) and one with subcutaneous belimumab (BLISS-SC). The 52-week landmark assessments were analysed across trials. Treatment response was defined according to BICLA criteria (BILAG improvement; no worsening of disease activity based on BILAG and Systemic Lupus Erythematosus Disease Activity Index-2K; no deterioration in Physician's Global Assessment ≥0.3 (scale: 0-3); no treatment failure).RESULTS: A total of 3086 patients received belimumab (n=1869) or placebo (n=1217). BICLA response frequencies at week 52 were greater with belimumab vs placebo in BLISS-52 (OR (95% CI): 1.49 (1.05-2.12); p=0.024), BLISS-NEA (1.62 (1.12-2.33); p=0.010) and BLISS-SC (1.89 (1.39-2.57); p<0.001). A highly significant difference was observed in the pooled population (1.47 (1.25-1.72); p<0.001; adjusted for trial variance). Belimumab yielded greater BICLA response frequencies than placebo irrespective of baseline glucocorticoid dose (>7.5 or ≤7.5 mg/day of a prednisone equivalent), in patients with baseline SLEDAI-2K≥10 and in patients with positive anti-double-stranded (ds)DNA and/or low C3/C4 levels at baseline. Belimumab combined with anti-malarials yielded greater frequency of BICLA response attainment.CONCLUSIONS: In this analysis of five RCTs evaluating belimumab in SLE, belimumab conferred superiority over placebo to yield BICLA response in the overall study population and in subgroups of patients with high global or serological activity at baseline. The benefit of belimumab was more prominent when combined with anti-malarials.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_calvnanna_2025, title = {Outdoor recreation, nature-based tourism and food: experiences and adaptations in the hospitality industry during the COVID-19 pandemic—a review}, author = {Calvén, Anna and Berry, Thomas and Kristofers, Hannah and Johansson, Marcus and Carlbäck, Mats and Wendin, Karin}, year = {2025}, journal = {Frontiers in Sustainable Tourism}, volume = {4}, doi = {10.3389/frsut.2025.1529233}, url = {1937540}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {covid-19 pandemic; friluftsliv; nature-based outdoor recreation; resilience; rural tourism; sweden}, abstract = {During the COVID-19 pandemic, participation in outdoor recreation increased in several countries, with nature taking on an expanded role as a social space for meetings and activities with food. This development may have created opportunities for nature-based hospitality providers to navigate the pandemic crisis. This review examines how food and eating were part of outdoor recreation and nature-based tourism during COVID-19, focusing on hospitality providers in rural Sweden. A literature search was performed for research articles, newspapers, and magazine articles. The results show creativity in adapting to new outdoor and nature tourism situations. The main findings that emerged focused on local and national guests, preventing the spread of infection, food as part of the experience in nature, experience packages, comfort, local food, food trucks and takeaway food, and other hospitality industry changes. Trends observed before COVID-19 but accelerating during the pandemic were also highlighted. Further research is needed to improve our understanding of food as part of outdoor recreation and nature-based tourism and how this knowledge can support sustainable thinking in the hospitality sector while contributing to resilient rural development.}, issn = {2813-2815} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_2025_4, title = {Overall report on results of the eight thematic research lines : Intersectional and qualitative comparative analyses}, year = {2025}, doi = {10.5281/zenodo.15532836}, url = {1992401}, language = {eng}, keywords = {green transition; eu green deal; behavior change; environmental policy; gender; intersectionality; environmental justice} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_kofodlinettemarie_2025_2, title = {Oxygen on the move : Reducing hypoxemia indaily life for patients with COPD}, author = {Kofod, Linette Marie}, year = {2025}, url = {1955394}, language = {eng}, publisher = {Örebro University}, keywords = {long-term oxygen therapy; closed-loop; desaturation; automated oxygen titration}, abstract = {Patients with COPD on long-term oxygen therapy (LTOT) often experience fluctuations in oxygen demand during walking, daily activities, and rest. Conventional fixed-dose oxygen therapy fails to adequately meet these dynamic needs, leading to episodes of hypoxemia that may negatively impact dyspnea, exercise endurance, and overall quality of life. Automated oxygen titration systems, have the potential to optimize oxygen delivery by adjusting flow rates in real time based on oxygen saturation (SpO₂).This thesis consists of four studies evaluating the feasibility, efficacy and patient experience of reducing hypoxemia using automated oxygen titration in patients with COPD on LTOT across walking, activities of daily living (ADL), and in the home environment. Two randomized crossover trials, one randomized crossover feasibility trial and a qualitative interview study were conducted. Oxygen flow was adjusted to maintain SpO₂ between 90-94% and compared to usual fixed-dose oxygen.Automated titration significantly increased time spent within target saturation and reduced episodes of hypoxemia compared to usual oxygen dose. It required a wide flow range and continuous monitoring. The improvements in oxygenation were associated with increased walking distance, enhanced ADL performance, and reduced dyspnea. At home, improving SpO₂ proved feasible, with high patient acceptance and it seemed to positively affect self-reported health. Patients described more ease daily functioning and expressed optimism about the technology.}, file = {https://oru.diva-portal.org/smash/get/diva2:1955394/FULLTEXT02.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_falkenbergmrten_2025, title = {Paclitaxel-coated versus uncoated devices for infrainguinal endovascular revascularisation in chronic limb-threatening ischaemia (SWEDEPAD 1) : a multicentre, participant-masked, registry-based, randomised controlled trial}, author = {Falkenberg, Mårten and James, Stefan and Andersson, Manne and Andersson, Mattias and Delle, Martin and Engström, Jan and Fransson, Torbjörn and Gillgren, Peter and Hilbertson, Anna and Hörer, Tal M. and Jacobsson, Eva and Kragsterman, Björn and Lindbäck, Johan and Lindgren, Hans and Ludwigs, Karin and Mellander, Stefan and Nelzén, Olle and Olin, Robert and Sigvant, Birgitta and Skoog, Per and Starck, Joachim and Tegler, Gustaf and Thorbjørnsen, Knut and Truedson, Maria and Wahlgren, Carl-Magnus and Wallinder, Jonas and Öjersjö, Andreas and Nordanstig, Joakim}, year = {2025}, journal = {The Lancet}, volume = {406}, number = {10508}, pages = {1103--1114}, doi = {10.1016/S0140-6736(25)01585-5}, url = {1994994}, language = {eng}, publisher = {Elsevier}, abstract = {BACKGROUND: Drug-coated devices are frequently used in coronary and peripheral interventions, but their effect on amputation risk in peripheral artery disease is unclear. We assessed whether drug-coated devices affect the rate of above-ankle amputation in patients with chronic limb-threatening ischaemia undergoing infrainguinal endovascular revascularisation.METHODS: The Swedish Drug-Elution Trial in Peripheral Arterial Disease 1 (SWEDEPAD 1) was a pragmatic, nationwide, multicentre, participant-masked, registry-based, randomised controlled trial at 22 Swedish centres. Adult patients with Rutherford category 4-6 peripheral artery disease scheduled for infrainguinal endovascular treatment were eligible for inclusion. Participants were randomly allocated in a 1:1 ratio after successful guidewire crossing to receive either paclitaxel-coated or uncoated balloons or stents. Randomisation was stratified by centre and performed using a computer-generated sequence with allocation concealment via a secure, registry-embedded web system. The primary efficacy endpoint was ipsilateral major amputation (above the ankle) during follow-up. All analyses were done in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02051088) and the primary analysis is complete; further analyses are ongoing.FINDINGS: From Nov 5, 2014, to Sept 29, 2023, 2400 patients were randomly assigned to treatment with paclitaxel-coated devices (n=1206) or with uncoated devices (n=1194). 2355 patients were included in the intention-to-treat analysis (1180 in the paclitaxel-coated group and 1175 in the uncoated group). The median age was 77 years (IQR 71-83), 1317 (55·9%) of 2355 patients were male and 1038 (44·1%) were female, and 1237 (52·6%) patients had preoperative diabetes. Median follow-up was 2·67 years (IQR 1·08-4·78). Most patients (1761 [74·9%] of 2351) had wounds or tissue loss (Rutherford stage 5 or 6). Treated lesions were located in the femoropopliteal vascular segment in 1241 (52·7%) of 2355 patients, in the infrapopliteal segment in 537 (22·8%) patients, and in both segments in 561 (23·8%) patients. Nearly all paclitaxel-coated devices (>99%) used paclitaxel as the coating agent (>99%). There was no significant difference in the rate of ipsilateral major amputation between using paclitaxel-coated or uncoated devices (hazard ratio [HR] 1·05 [95% CI 0·87-1·27]; p=0·61) with maximum of 5 years of follow-up. There was no difference in all-cause mortality (HR 1·04 [95% CI 0·92-1·17]; p=0·54).INTERPRETATION: In patients with chronic limb-threatening ischaemia undergoing infrainguinal endovascular revascularisation, paclitaxel-coated devices did not reduce major ipsilateral amputations.}, issn = {0140-6736} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nordanstigjoakim_2025, title = {Paclitaxel-coated versus uncoated devices for infrainguinal endovascular revascularisation in patients with intermittent claudication (SWEDEPAD 2) : a multicentre, participant-masked, registry-based, randomised controlled trial}, author = {Nordanstig, Joakim and James, Stefan and Andersson, Manne and Andersson, Mattias and Delle, Martin and Engström, Jan and Fransson, Torbjörn and Gillgren, Peter and Hilbertson, Anna and Hörer, Tal M. and Jacobsson, Eva and Kragsterman, Björn and Lindbäck, Johan and Lindgren, Hans and Ludwigs, Karin and Mellander, Stefan and Nelzén, Olle and Olin, Robert and Sigvant, Birgitta and Skoog, Per and Starck, Joachim and Tegler, Gustaf and Thorbjørnsen, Knut and Truedson, Maria and Wahlgren, Carl-Magnus and Wallinder, Jonas and Öjersjö, Andreas and Falkenberg, Mårten}, year = {2025}, journal = {The Lancet}, volume = {406}, number = {10508}, pages = {1115--1127}, doi = {10.1016/S0140-6736(25)01584-3}, url = {1994984}, language = {eng}, publisher = {Elsevier}, abstract = {BACKGROUND: Drug-coated devices are widely used to reduce restenosis after lower limb revascularisation in patients with peripheral artery disease, but their effect on patient-centred outcomes remains unclear. We assessed the effect of paclitaxel-coated devices on clinically important outcomes in patients with intermittent claudication undergoing infrainguinal endovascular revascularisation.METHODS: The Swedish Drug-Elution Trial in Peripheral Arterial Disease 2 (SWEDEPAD 2) was a pragmatic, nationwide, multicentre, participant-masked, registry-based, randomised controlled trial conducted at 22 Swedish vascular centres. Adults 18 years or older with intermittent claudication (Rutherford categories 1-3) undergoing infrainguinal endovascular treatment and with no acute thromboembolic disease of the lower limb or infrainguinal aneurysmal disease were eligible for inclusion. Participants were randomly assigned in a 1:1 ratio after successful guidewire crossing to receive either paclitaxel-coated devices or uncoated balloons or stents. Randomisation was stratified by centre and performed using a computer-generated sequence with allocation concealment via a secure, registry-embedded web system. The primary efficacy endpoint was the between-group difference in quality of life at 1 year, assessed with the six-item Vascular Quality of Life Questionnaire (VascuQoL-6), a peripheral artery disease-specific quality of life instrument. The trial is registered at ClinicalTrials.gov (NCT02051088) and the primary analysis is complete; further analyses are ongoing. FINDINGS: Between Nov 5, 2014, and Sept 27, 2023, a total of 1155 patients were enrolled and randomly assigned across 22 vascular centres in Sweden, of whom 1136 (98·3%) had follow-up data available for analysis. 577 patients were randomly assigned to paclitaxel-coated devices and 578 to uncoated devices, of whom 565 (97·9%) and 571 (98·7%) were included in the intention-to-treat population, respectively. The median age in the analysed cohort was 73·0 years (IQR 68·0-78·0). Of the 1136 patients, 612 (53·9%) were male and 524 (46·1%) were female; and 382 (33·7%) of 1135 had preoperative diabetes (one participant in the paclitaxel-coated device group was missing data). Most patients (677 [59·6%] of 1135) presented with severe claudication (Rutherford category 3). Femoropopliteal interventions were performed in 1092 patients (96·1%). At 1 year, VascuQoL-6 scores did not differ between groups (mean difference -0·02 [95% CI -0·66 to 0·62]; p=0·96). All-cause mortality did not differ over a median 7·1 years (IQR 3·9-8·2); hazard ratio (HR) 1·18 (95% CI 0·94-1·48); p=0·16, although 5-year mortality incidence was higher in patients randomly assigned to the paclitaxel-coated devices group (4·57 vs 3·28 per 100 person-years; HR 1·47 [95% CI 1·09-1·98]; p=0·010).INTERPRETATION: In patients with Rutherford stage 1-3 peripheral artery disease undergoing infrainguinal endovascular revascularisation, paclitaxel-coated devices did not improve disease-specific quality of life at 1 year compared with uncoated devices. All-cause mortality was not different over the total follow-up time, but significantly higher over 5 years. These findings do not support routine use of paclitaxel-coated devices in this patient population.}, issn = {0140-6736} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_olssonemma_2025_1, title = {Pain and sedation management for screening or treatment of retinopathy of prematurity}, author = {Olsson, Emma and Romantsik, Olga and Lundgren, Pia and Fiander, Michelle and Snellman, Alexandra and Hellstrom, Ann and Bruschettini, Matteo}, year = {2025}, journal = {Cochrane Database of Systematic Reviews}, volume = {5}, doi = {10.1002/14651858.CD016171}, url = {1957044}, language = {eng}, publisher = {John Wiley & Sons}, abstract = {Study protocolThis is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of pain and sedation management for screening or treatment of retinopathy of prematurity in preterm infants compared to placebo, no intervention, or other interventions.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_campbellyeomarsha_2025, title = {Pain in the Newborn and Infant}, author = {Campbell-Yeo, Marsha and Eriksson, Mats}, year = {2025}, doi = {10.1891/9780826149725.0022}, url = {2025275}, language = {eng}, publisher = {Springer Publishing Company}, keywords = {acute pain; analgesic therapies; developmental changes; developmental neurophysiology; neonatal pain assessment; neonatal pain management; pharmacologic therapies; postoperative pain; preemptive analgesia; procedural pain}, abstract = {Despite advances in neonatal pain assessment and management, nonpharmacologic and pharmacologic analgesic therapies continue to be underutilized to manage both acute and procedural pain. This chapter reviews the developmental neurophysiology of pain, discusses methods to assess pain in infants, highlights factors that influence the pain experience, and discusses evidence-based strategies for managing infant pain. It emphasizes the developmental and maturational changes that occur during infancy and childhood. Selection of an appropriate clinical pain assessment method should be based first on the developmental age of the infant and second on the type of pain experienced. Depending on duration and severity, pain may be successfully managed with nonpharmacologic comfort measures and/or pharmacologic therapies. Pain management techniques may vary on the basis of pain type and clinical situation. The chapter reviews special issues related to procedural pain, postoperative pain, preemptive analgesia for mechanical ventilation, and pain management at end of life.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tenbargejuditha_2025, title = {Pain management in preterm infants with necrotizing enterocolitis : an international expert consensus statement}, author = {Ten Barge, Judith A. and van den Bosch, Gerbrich E. and Allegaert, Karel and Bhatt, Aomesh and Brindley, Nicola and Byrne, Dearbhla and Campbell-Yeo, Marsha and Camprubi-Camprubi, Marta and Cavallaro, Giacomo and Durrmeyer, Xavier and Embleton, Nicholas and Eriksson, Mats and Flint, Robert B. and Garrido, Felipe and Giannì, Maria Lorella and Giannoni, Eric and Kitt, Heather and Klerk, Daphne and Kristjánsdóttir, Guðrún and Amponsah, Abigail Kusi and Lapillonne, Alexandre and Martin, Camilia R. and Matyas, Melinda and Norman, Elisabeth and Ohja, Shalini and Pirlotte, Sofie and Del Rio, Ruth and Roué, Jean-Michel and Sevivas, Catarina and Slater, Rebeccah and Smits, Anne and de Pipaon, Miguel Saenz and Tauzin, Manon and Ukkonen, Tiina and Unal, Sezin and Villamor, Eduardo and Molloy, Eleanor J. and Simons, Sinno H. P.}, year = {2025}, journal = {European Journal of Pediatrics}, volume = {184}, number = {6}, doi = {10.1007/s00431-025-06168-8}, url = {1958434}, language = {eng}, publisher = {Springer}, keywords = {necrotizing enterocolitis; pain management; preterm infants}, abstract = {Necrotizing enterocolitis (NEC) is probably the most painful intestinal disease affecting infants born preterm. NEC is known to cause highly severe and prolonged pain that has been associated with adverse short- and long-term effects. However, research on pain management in infants with NEC is scarce. This is likely due to its low incidence and very acute occurrence. As a result, the optimal pain management for these vulnerable infants remains unknown, and analgesic therapy practices are highly variable. Therefore, we aimed to establish expert-based consensus recommendations on pain management for NEC. Experts of the European Society for Paediatric Research (ESPR) Special Interest Groups on Neonatal pain and NEC were invited to participate in two consensus meetings. Prior to the first hybrid consensus meeting, an online survey provided input for potential recommendations. During the consensus meetings, experts shared clinical expertise and voted on recommendations. An expert consensus statement, comprising nine recommendations on optimal pain assessment and pain treatment in infants with NEC, was developed. Expert recommendations included regular pain assessments with a neonatal pain scale with additional assessments on indication and pre-emptive administration of analgesic therapy (e.g., paracetamol and an opioid) in infants with NEC stage ≥ II.CONCLUSION: This expert consensus statement provides clinical recommendations essential for any healthcare professional caring for premature infants with NEC. The recommended guidance this statement provides on pain management strategies is key to preventing and reducing pain in this vulnerable population.WHAT IS KNOWN:• Necrotizing enterocolitis (NEC) is a very painful disease, making effective pain management essential.• Current pain management practices for infants with NEC are highly variable.WHAT IS NEW:• This expert consensus statement provides recommendations on optimal pain assessment and pain treatment in infants with NEC.• These clinical recommendations may help better prevent pain in these vulnerable infants.}, issn = {0340-6199} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stormerika_2025, title = {Palliative nurses' experiences of alleviating suffering and preserving dignity}, author = {Storm, Erika and Bergdahl, Elisabeth and Tranvåg, Oscar and Korzhina, Yulia and Linnanen, Cecilia and Blomqvist, Heidi and Hemberg, Jessica}, year = {2025}, journal = {Nursing Ethics}, volume = {32}, number = {7}, pages = {2018--2032}, doi = {10.1177/09697330251326235}, url = {1946422}, language = {eng}, publisher = {Sage Publications}, keywords = {caring; compassion; dignity; ethical sensitivity; palliative homecare; suffering}, abstract = {Background: Most patients in need of palliative care remain in their homes, thus great focus should be placed on the creation of functional palliative homecare. Suffering through an often multifaceted illness and contemplating one's death can contribute to the loss of one's sense of dignity, and the preservation of patient dignity is a major challenge for health professionals worldwide.Aim: The aim of the study was to explore and describe nurses' experiences of caring qualities alleviating suffering and preserving the dignity of patients in need of palliative homecare.Research design: A qualitative exploratory study. In-depth semi-structured interviews as data collection method, and the qualitative content analysis of Graneheim and Lundman for data analysis. The theoretical perspective was based on Eriksson's caritative caring theory.Participants and research context: A total of nine nurses with extensive work experience from a palliative homecare context participated in the study.Ethical considerations: The study was conducted in accordance with the criteria set forth by the Finnish National Board on Research Integrity TENK. Research permission was granted and participants gave their written informed consent to participate in the study.Findings: One main theme and three subthemes were found. The main theme was: Being there for the other alleviates suffering while shaping and reshaping dignity preservation in a process. The three subthemes were: (1) Being a sensitive and compassionate witness who becomes responsible, (2) Having compliance, courage, and perception in a deep presence, (3) Being calm and patient while having time for conducting skilled practical knowledge.Conclusions: Certain caring qualities are important in the dignity-preserving care of people in need of palliative homecare, and person-centeredness plays a central role in alleviating suffering. Deep and trusting caring relationships and nurses' ability to customize the care being provided are significant in alleviating patient suffering and preserving dignity.}, issn = {0969-7330} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_qvickalvida_2025, title = {Pan-Cancer Detection Through DNA Methylation Profiling Using Enzymatic Conversion Library Preparation with Targeted Sequencing}, author = {Qvick, Alvida and Adolfsson, Emma and Tornéus, Lina and Lindqvist, Carl Mårten and Carlsson, Jessica and Stenmark, Bianca and Karlsson, Christina and Helenius, Gisela}, year = {2025}, journal = {International Journal of Molecular Sciences}, volume = {26}, number = {20}, doi = {10.3390/ijms262010165}, url = {2010458}, language = {eng}, publisher = {MDPI}, keywords = {cfdna; epigenetics; liquid biopsy; methylation; next-generation sequencing; pan-cancer}, abstract = {We investigated differences in circulating cell-free DNA (cfDNA) methylation between patients with cancer and those presenting with severe, nonspecific symptoms. Plasma cfDNA from 229 patients was analyzed, of whom 37 were diagnosed with a wide spectrum of cancer types within 12 months. Samples underwent enzymatic conversion, library preparation, and enrichment using the NEBNext workflow and Twist pan-cancer methylation panel, followed by sequencing. Methylation analysis was performed with nf-core/methylseq. Differentially methylated regions (DMRs) were identified with DMRichR. Machine learning with cross-validation was used to classify cancer and controls. The classifier was applied to an external validation set of 144 controls previously unseen by the model. Cancer samples showed higher overall CpG methylation than controls (1.82% vs. 1.34%, p < 0.001). A total of 162 DMRs were detected, 95.7% being hypermethylated in cancer. Machine learning identified 20 key DMRs for classification between cancer and controls. The final model achieved an AUC of 0.88 (83.8% sensitivity, 83.8% specificity), while mean cross-validation performance reached an AUC of 0.73 (57.1% sensitivity, 77.5% specificity). The specificity of the classifier on unseen control samples was 79.2%. Distinct methylation differences and DMR-based classification support cfDNA methylation as a robust biomarker for cancer detection in patients with confounding conditions.}, issn = {1661-6596} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vujasinovicmiroslav_2025_1, title = {Pancreatic Exocrine Insufficiency Is Not Uncommon in Celiac Disease : A Systematic Review and Meta-Analysis}, author = {Vujasinovic, Miroslav and Blazevic, Nina and Maisonneuve, Patrick and Forss, Anders and Panic, Nikola and Bloch, Nina and Dominguez Munoz, J. Enrique and Ludvigsson, Jonas F. and Löhr, J-Matthias}, year = {2025}, journal = {United European Gastroenterology journal}, volume = {13}, number = {7}, pages = {1107--1115}, doi = {10.1002/ueg2.70076}, url = {1983212}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {celiac disease; enzyme replacement therapy; gluten‐free diet; malabsorption; meta‐analysis; pancreatic exocrine insufficiency; prevalence}, abstract = {INTRODUCTION: Pancreatic exocrine insufficiency (PEI) is seen in primary pancreatic disease but has also been seen in extrapancreatic conditions including celiac disease (CeD). The symptoms of PEI and CeD often overlap, which makes diagnostics challenging. In this systematic review and meta-analysis, we aimed to investigate the prevalence of PEI in CeD.METHODS: With the assistance of a professional librarian, we searched five databases: PubMed, Embase, Cochrane, Web of Science Core Collection, and Google Scholar, up until October 21, 2024. The pooled prevalence of PEI in biopsy-confirmed CeD was estimated, and the quality of studies appraised.RESULTS: We identified and screened the titles and abstracts of 1432 publications, of which 60 were reviewed in full text and 12 were included in the analyses. The overall pooled weighted prevalence of PEI in CeD was 13.5% (95% CI 7.2-21.0). The prevalence was similar among children (14.2%; 95% CI 2.0-32.8) and adults (12.8%; 95% CI 7.8-18.7) with CeD. The prevalence in studies that used secretory testing to define PEI was 13.1% (95% CI 6.4-21.3) and in those requiring digestive tests 17.1% (95% CI 5.8-32.1). The weighted prevalence of PEI was significantly higher among untreated CeD patients (18.2%) than patients on a gluten-free diet (6.9%) (p = 0.03), in both adults and children.CONCLUSION: One in eight individuals with CeD may suffer from PEI. The prevalence was particularly high in untreated CeD. PEI should be considered in patients who do not respond to a gluten-free diet.}, issn = {2050-6406} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_svedmyrsven_2025, title = {PAP treatment reduces the excess mortality risk of obstructive sleep apnea}, author = {Svedmyr, Sven and Zou, Ding and Hedner, Jan and Ekström, Magnus and Ljunggren, Mirjam and Sundh, Josefin and Palm, Andreas and Grote, Ludger}, year = {2025}, journal = {European Respiratory Journal}, volume = {66}, number = {Suppl. 69}, doi = {10.1183/13993003.congress-2025.PA5624}, url = {2039383}, language = {eng}, publisher = {European Respiratory Society}, issn = {0903-1936} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_markenmoa_2025, title = {Pappa Strindberg : Några biografiska reflektioner}, author = {Marken, Moa}, year = {2025}, pages = {75--83}, url = {2011703}, language = {swe}, publisher = {Strindbergssällskapet}, keywords = {august strindberg; pappa; faderskap} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_pramlingniklas_2025, title = {Paradigmatic and narrative forms of knowledge in read-aloud practices and their implications for the further learning and education of children}, author = {Pramling, Niklas and Simonsson, Maria and Norling, Martina}, year = {2025}, journal = {Learning, Culture and Social Interaction}, volume = {55}, doi = {10.1016/j.lcsi.2025.100957}, url = {2016224}, language = {eng}, publisher = {Elsevier}, keywords = {read-aloud practices; paradigmatic; narrative; sociocultural perspective; cultural tools and practices}, abstract = {This article investigates how different forms of knowledge are actualised during read-aloud activities in preschool. More specifically, informed by the distinction between two fundamental modes of knowledge or sensemaking, narrative and paradigmatic, we analyse how the latter (typified by scientific discourse) comes to the fore and is responded to during read-aloud activities when a book about a technological problem is read, discussed, and further followed up in a Swedish preschool setting. The empirical data consists of video observations. Theoretically, the study builds on a sociocultural perspective that conceptualises learning in terms of the appropriation of cultural tools and practices. What tools (e.g., forms of knowledge) and practices (e.g. read-aloud ones) children encounter and are supported in appropriating during their early education therefore emerge as critical to their development. This interest informs the overarching research project into read-aloud practices in preschool of which the present study forms a part. The results show that paradigmatic knowledge (here in the form of technology) is generally rendered and responded to in a narrative way. However, the ensuing talk can be characterised as a form of hybrid discourse between these modes. The pros and cons of such discourse mixing is discussed in terms of their implications for children's learning.}, issn = {2210-6561} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wangjian_2025, title = {Parental Perception, Concern, and Dissatisfaction With Preschool Children's Weight and Their Associations With Feeding Practices in a Chinese Sample : A Cross-Sectional Study}, author = {Wang, Jian and Winkley, Kirsty and Wei, Xiaoxue and Cao, Yang and Chang, Yan-Shing}, year = {2025}, journal = {Journal of nutrition education and behavior}, volume = {57}, number = {6}, pages = {482--496}, doi = {10.1016/j.jneb.2025.02.012}, url = {1948514}, language = {eng}, publisher = {Elsevier}, keywords = {feeding practices; parents; perception; preschool children; weight dissatisfaction}, abstract = {OBJECTIVE: To examine the associations between parental perception, concern, and dissatisfaction with child weight and their feeding practices among Chinese families. DESIGN: A cross-sectional study.SETTING: Four public kindergartens in Yangzhou, China. PARTICIPANTS: Chinese parents of preschool children (n = 1,779).MAIN OUTCOME MEASURES: Three responsive feeding practices (i.e., encouragement of healthy eating, monitoring, and modeling) and 3 nonresponsive feeding practices (i.e., pressure to eat, restriction, and use of food as a reward).ANALYSIS: Hierarchical multiple regression analysis was performed to examine their associations. The agreement was evaluated with kappa statistics.RESULTS: Parents who perceived children as overweight or obese reported less pressure to eat (P = 0.04); parents who were concerned about children with underweight reported more pressure to eat (P = 0.01); parents who rated children's body weight size as underweight were less likely to encourage children to eat healthy food (P = 0.04) and restrict food intake (P = 0.02); parents who desired a slimmer child's body size reported less modeling (P < 0.001) and more restriction (P = 0.04). The disagreements between parental self-reported and visual perception of child weight and actual child weight were statistically significant, respectively (P < 0.01).CONCLUSIONS AND IMPLICATIONS: The results suggested the significant influence of parental perception, concern, and dissatisfaction with child weight on feeding practices. Our findings may inform public health practitioners and primary care providers in designing interventions to enhance parental accurate weight perception and optimize feeding practices.}, issn = {1499-4046} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gundersentw_2025, title = {Parental socioeconomic status and risk of poor pregnancy outcomes in pregnancies with maternal type 1 diabetes}, author = {Gundersen, T. W. and Clausen, T. D. and Ringholm, L. and Jensen, D. M. and Damm, P. and Nielsen, K. Kragelund and Backman, Helena and Lauenborg, J. and Mathiesen, E. R. and Skipper, N. and Kofoed-Enevoldsen, A. and Knorr, S.}, year = {2025}, journal = {Diabetologia}, volume = {68}, number = {Suppl. 1}, pages = {S185--S186}, url = {2039826}, language = {eng}, publisher = {Springer}, abstract = {Background and aims: Type 1 diabetes is associated with poor pregnancy outcomes, yet the role of both maternal and paternal socioeconomic status (SES) in modifying these risks remains understudied. This study investigates the association between parental SES and the risk of preterm delivery and extreme large for gestational age (LGA) infants in pregnancies with maternal type 1 diabetes.Materials and methods: From the Danish nationwide registers, wei ncluded all pregnancies with maternal type 1 diabetes from 1997 to 2021. Outcomes were preterm delivery (before 37 weeks) and extreme LGA (birth weight ≥2SD above the mean, adjusted for sex and gestational age). Exposures included five measures of low SES: family relative poverty (family income below 50% of the median for the population the year prior to delivery), low education (primary school or less) for mother or father, and mother or father receiving cash or disability benefits. For each measure of low SES, we calculated relative risk (RR) and 95% confidence intervals (CI) of delivering preterm or extreme LGA infants using logistic regression models and regression standardization. Models were adjusted for maternal birth year and parental immigration status.Results: 5478 pregnancies from 3434 women were analyzed. The median maternal age was 30.8 years, and 7.5% of mothers and 10.3% of fathers were immigrants or descendants. 32.5% of deliveries were preterm, and 36% of infants were born extreme LGA. Relative poverty was present in 5.6% of the population, while 17.9 % of mothers and 18.9 % of fathers had low education, and 13.6% of mothers and 5.4% of fathers received cash or disability benefits. All measures of low SES were associated with a significantly increased risk of preterm delivery in the adjusted models (ranging from RR 1.24 (95% CI 1.03 to1.45) to 1.42 (95% CI 1.23 to 1.62)). Besides a significant reduction in the risk of extreme LGA when the mother (RR 0.87 (95% CI 0.76 to 0.98) or father (RR 0.82 (95% CI 0.65 to 0.98) received cash or disability benefits, no measure of low SES was associated with extreme LGA in the adjusted models (ranging from RR 0.94 (95% CI 0.0.84 to 1.05)) to 0.98 (95% CI 0.82 to 1.15)).Conclusion: Low SES was associated with a significantly increased risk of preterm delivery but not with extreme LGA. Studies evaluating the effect of tailored support to pregnant women with low SES are warranted.}, issn = {0012-186X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_chenyujia_2025, title = {Parental weight perception and non-responsive feeding practices in Chinese preschoolers : a prospective longitudinal study}, author = {Chen, Yujia and Qu, Fangge and Song, Xinyi and Wei, Xiaoxue and Wu, Ruxing and Wang, Jian and Cao, Yang and Hua, Wenzhe and Tang, Xianqing and Zhu, Daqiao}, year = {2025}, journal = {European Journal of Pediatrics}, volume = {184}, number = {9}, doi = {10.1007/s00431-025-06361-9}, url = {1990110}, language = {eng}, publisher = {Springer}, keywords = {longitudinal; non-responsive feeding practice; parent; preschooler; weight perception}, abstract = {Parental perception of their child's weight may influence their feeding practices. However, few studies examined the longitudinal associations and the potential sex differences within it. Considering that parents may perceive and respond differently to boys' and girls' weight status due to biological and sociocultural expectations, it is important to investigate potential sex differences. The prospective cohort study aims to examine the associations between parental weight perception and their non-responsive feeding practices in preschool children and explore child sex differences in the association. Parent-child dyads (n = 426, Mage = 3.76, SD = 0.50, 53.6%boys) were surveyed at two time points separated by a 2-year interval in China. Generalized estimating equations (GEE) were conducted to examine longitudinal associations between parental weight perception and non-responsive feeding practices (restrictive feeding, food as a reward, and pressure to eat), adjusting for key confounders, including child age, body mass index-for-age z-score (BAZ), having siblings, primary caregiver identity, and grandparent-parent parenting. Sex-stratified analyses were conducted to examine whether the associations differed between boys and girls. Parental underweight perception was associated with restrictive feeding (B =  - 0.260, p = 0.004) and pressure to eat (B = 0.350, p < 0.001), but not with food as rewards (B = 0.015, p = 0.868) in the overall sample. However, parental overweight and obesity (OWOB) perception was not associated with restrictive feeding (B =  - 0.029, p = 0.819), food as a reward (B =  - 0.228, p = 0.146), and pressure to eat (B =  - 0.284, p = 0.054). Among boys, underweight perception was associated with restrictive feeding (B =  - 0.205, p = 0.023) and pressure to eat (B = 0.362, p < 0.001); OWOB perception was associated with pressure to eat (B =  - 0.325, p = 0.024). While no significant associations were observed among girls for restrictive feeding, food as a reward, and pressure to eat.CONCLUSION: Findings in this study suggested that the longitudinal associations between parental weight perception and feeding practices differed by sex among Chinese preschool children. Healthcare providers should consider offering anticipatory guidance to parents who perceive their child's weight as abnormal, educating them on evidence-based, sex-specific strategies to promote healthy feeding practices.WHAT IS KNOWN: • Cross-sectional studies suggest that parental weight perception is associated with non-responsive feeding practices and that these associations may differ by child sex. • In China, cultural beliefs such as "a chubby child is a healthy child" may lead parents to underestimate their child's weight, potentially influencing their feeding behaviors. WHAT IS NEW: • This longitudinal study in urban Chinese preschoolers found that parental underweight perception was associated with increased pressure to eat and reduced restrictive feeding over time. • These associations were observed only among boys, highlighting potential sex-specific mechanisms shaped by cultural norms as early as the preschool years.}, issn = {0340-6199} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_duberganna_2025, title = {Parent–child agreement in reporting somatic distress, gastrointestinal symptoms, mental health, and general health in girls with functional abdominal pain}, author = {Duberg, Anna and Eriksson, Mats and Philipson, Anna}, year = {2025}, journal = {European Journal of Pediatrics}, volume = {184}, number = {12}, doi = {10.1007/s00431-025-06640-5}, url = {2015839}, language = {eng}, publisher = {Springer}, keywords = {functional abdominal pain disorders; irritable bowel syndrome; mental health symptoms; parent–child agreement; general health; somatic distress}, abstract = {To examine the inter-rater agreement between parent- and child-reported measures of somatic distress, gastrointestinal symptoms, mental health, and general health in girls aged 9–13 years with functional abdominal pain disorders (FAPDs). This secondary analysis used data from the Just in TIME randomized controlled trial, including girls aged 9–13 years with FAPDs. Both girls and their parents completed the Children’s Somatic Symptoms Inventory (gastrointestinal distress (CSSI-GI) and somatic distress (CSSI-nonGI) subscales) and answered questions about general health and mental health symptoms, measures at baseline and after 8 months. Agreement was assessed using intra-class correlation (ICC) and linear-weighted Cohen’s kappa. Data from 121 girls (mean age 10.6 years) and their parents were analysed. For CSSI-GI, mean scores were similar at baseline (girls 6.98, parents 7.27; ICC 0.84, p < .001) and follow-up (girls 4.25, parents 4.16; ICC 0.91, p < .001). For CSSI-nonGI, girls reported higher mean scores than parents at baseline (8.75 vs. 6.79; ICC 0.75, p < .001) and follow-up (7.14 vs. 5.43; ICC 0.78, p < .001). Agreement for general health was fair (kappa 0.31 at baseline, 0.41 at follow-up, both p < .001). For mental health symptoms, agreement ranged from slight to moderate (kappa 0.20–0.52 at baseline; 0.11–0.46 at follow-up, all significant).Conclusion: Findings indicated good parent– and child agreement for gastrointestinal and general somatic symptoms, but lower agreement for mental health and general health.}, issn = {0340-6199} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_randelleva_2025_1, title = {Parenting Young Children (PYC) for parents with intellectual and developmental disabilities : parents' experiences of the support program's methodology}, author = {Randell, Eva and Forslund, Tommie and Strandberg, Thomas and Holmefur, Marie and Wennberg, Birgitta}, year = {2025}, journal = {Journal of Intellectual & Developmental Disability}, doi = {10.3109/13668250.2025.2572401}, url = {2011557}, language = {eng}, publisher = {Taylor & Francis}, keywords = {cognitive; parenting young children (pyc); intellectual and developmental disabilities; modelling; parenting support program; social and pedagogical support}, abstract = {BACKGROUND: Research on how parents with intellectual and developmental disabilities perceive the Parenting Young Children (PTC) support program for the development of parenting skills is scarce. The study explored parents' experiences of PYC's methodology.METHOD: Interviews were conducted with 15 Swedish parents (8 mothers, 7 fathers) at risk for child neglect who had received PYC for 6 months or longer. The interviews were analysed with reflexive thematic analysis.RESULTS: Two main themes, with six subthemes, were identified: "Developing a trusting relationship with the PYC practitioner" and "Tailored support, planning, and training in collaboration." One overarching theme was also created: "The PYC methodology facilitates learning of parenting skills through a trusting and collaborative process guided by adapted support."CONCLUSION: Parents with intellectual and developmental disabilities perceived the PYC methodology as helpful and well-adapted. The study highlights that learning parenting skills can be facilitated by a collaborative and tailored approach using behavioural teaching strategies.}, issn = {1366-8250} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssoncharlotte_2025, title = {Participation in the Habilitation Process, from the Perspective of Young People}, author = {Karlsson, Charlotte and Andersson, Anna Karin and Lundqvist, Lars-Olov and Huus, Karina}, year = {2025}, journal = {Scandinavian Journal of Disability Research}, volume = {27}, number = {1}, pages = {227--239}, doi = {10.16993/sjdr.1086}, url = {1985963}, language = {eng}, publisher = {Stockholm University Press}, keywords = {disabilities; participation; rehabilitation; qualitative research; young people}, abstract = {Young people have the right to participate in their habilitation process. The aim was to describe how young people with disabilities perceive participation in the habilitation process. Data collection was performed at child and youth habilitation centres in Sweden. A total of four interviews were conducted, two individual interviews and two group interviews. The transcribed data was analysed using inductive qualitative content analysis. The analysis reveals two generic categories: 'the right prerequisites must be provided to be able to participate' and 'adults' behaviour and attitudes are important for participation in the habilitation process'. The findings reveal that how young people perceive participation in the habilitation process is based on environmental factors, such as information, and that the professionals strive for the young people's voices to be heard by including them in planning. In conclusion, the important aspects of participation are a young person-friendly environment and individual support from adults. These aspects can provide a source of reference for professionals who want to develop strategies to promote young people's participation.}, issn = {1501-7419} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alijagicandi_2025_3, title = {Particulate matter emitted in post-processing of additively manufactured metallic alloys induces acute inflammatory responses in human macrophages : a multi-omics approach}, author = {Alijagic, Andi and Hyötyläinen, Tuulia and Andersson, Lena and Salihovic, Samira and Sinisalu, Lisanna and Karlsson, Patrik and Persson, Alexander and Repsilber, Dirk and Odnevall, Inger and Särndahl, Eva and Engwall, Magnus}, year = {2025}, journal = {Toxicology Letters}, volume = {411}, number = {Suppl.}, pages = {S56--S56}, doi = {10.1016/j.toxlet.2025.07.164}, url = {2003727}, language = {eng}, publisher = {Elsevier}, abstract = {Metal additive manufacturing (AM), also known as industrial 3D printing, has revolutionized modern industry, enabling the creation of complex, high-performance components across sectors such as aerospace, automotive, and biomedicine. While the printing process itself is often well-contained, a critical and understudied phase – post-processing – has emerged as a source of potentially hazardous airborne particulate matter. These emissions may pose health risks to workers, particularly through interaction with the immune system, which serves as the body's first line of defense and a sentinel of environmental stressors. Yet, limited data exist on the physicochemical properties and immunotoxicological impact of these particles. This study aimed to assess the immunological consequences of particle emissions released during the post-processing of metallic AM alloys, using a human macrophage model and a multi-omics framework.Airborne particles were collected directly from an operational AM facility using a cascade impactor, separating them into five size fractions, ranging from coarse (>2.5 μm) to nanoscale (<250 nm). A comprehensive physicochemical characterization was performed using scanning electron microscopy with energy-dispersive spectroscopy and X-ray photoelectron spectroscopy. The emitted particles were highly heterogeneous, with irregular, sharp morphologies, and exhibited increased surface oxidation compared to virgin feedstock powders. Functional toxicological assessments were performed in human macrophages, including transmission electron microscopy to evaluate particle uptake. Macrophages, both resting and lipopolysaccharide-primed, displayed potent and dose-dependent inflammatory responses, as seen by elevated secretion of several cytokines (e.g., IL-1β, IL-6). RNA sequencing revealed profound alterations in macrophage gene expression, including dysregulation of NF-κB signaling, cellular senescence, and lipid metabolism pathways. Gene set enrichment analysis indicated broader perturbations in immune regulation and macrophage homeostasis. Non-targeted metabolomics demonstrated significant changes in intracellular metabolic profiles. Specifically, there was an upregulation of numerous lipids and a suppression of several metabolites involved in immunomodulation and cellular energy homeostasis, including tryptophan, NAD, and phenylalanine. Integrated multi-omics analysis revealed a coordinated crosstalk between transcriptional and metabolic responses, pointing to an acute and multifaceted inflammatory reprogramming of macrophages in response to post-processing AM particles.In conclusion, this study provides the first integrative multi-omics characterization of human immune cell responses to airborne particulate emissions from metal AM post-processing. These results not only advance the field of nanosafety in industrial AM environments but also underscore the urgent need for targeted risk mitigation strategies during post-processing.}, issn = {0378-4274} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_myrtveitstensrudlinn_2025, title = {Partner responses to pain among male partners of women with provoked vestibulodynia-a cross-sectional study}, author = {Myrtveit-Stensrud, Linn and Ekholm, Elin and Flink, Ida and Ter Kuile, Moniek and Engman, Linnea and Suvaal, Isabelle and Groven, Karen Synne and Reme, Silje Endresen}, year = {2025}, journal = {Pain Reports}, volume = {10}, number = {2}, doi = {10.1097/PR9.0000000000001265}, url = {1946357}, language = {eng}, publisher = {Wolters Kluwer}, keywords = {chronic pain; cross-sectional study; genito-pelvic pain; heterosexual couples; male partners; pvd; partner responses; vulvodynia; vulvovaginal pain}, abstract = {INTRODUCTION: Provoked vestibulodynia (PVD) is a prevalent persistent pain disorder, localized to the vulva, not only affecting the sexual health of women suffering from it but also of their partners. Partner's behavioral response to the pain has implications for the affected woman's pain and sexual function, as well as the relational dynamics of the couple.OBJECTIVES: The main aim of this study was to explore facilitative, solicitous, and negative male partner responses to women with PVD and their links to demographic and psychosexual characteristics. Further, we investigated the discrepancies in psychosexual health between currently sexually active and inactive participants, as well as levels of anxiety and depressive symptoms within our sample of male partners (N = 127).Methods: Cross-sectional associations were examined using bivariate correlations. Differences in psychosexual health between the two sub-samples were examined using Mann-Whitney U test.RESULTS: Our results showed that facilitative partner responses were significantly associated with higher relationship and sexual satisfaction, as well as with lower sexual distress and more approach goals. Negative partner responses were significantly associated with higher sexual distress, as well as with lower relationship and sexual satisfaction. Negative partner responses were the only responses significantly associated with the men's anxiety and depression, which suggests that mental health plays a role in partners' management of vulvodynia. In our sample, 10.2% scored above cut-off for clinical levels of depressive symptoms and 8.7% for anxiety, similar to a Swedish community sample.Conclusion: Partner responses were associated with psychosexual health. In our sample, male partners of women with PVD did not have more anxiety or depression than other men of the same age in the general population.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_leerjonatan_2025_2, title = {Pasta Grannies and Gourmet Chef : Critical perspectives on gender and food heritage}, author = {Leer, Jonatan}, year = {2025}, pages = {162--174}, doi = {10.4324/9781032026565-16}, url = {2029335}, language = {eng}, publisher = {Routledge}, abstract = {This chapter explores the overlooked role of gender in food heritage. The chapter analyzes how narratives on food heritage are gendered and how these narratives relate to questions of power. It opens with a more general introduction to the topic of food and gender and more specifically on food heritagization and gender. Then, it highlights dominant narratives within the gendering of food heritage in media and in projects and politics of food heritage. Finally, the chapter discusses the problematic consequences and how future studies on food and heritage might challenge these stereotypes and promote more gender equality in the domain of food heritage. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_farkassanjaa_2025, title = {Pathological variants in HPV-independent vulvar tumours}, author = {Farkas, Sanja A. and Qvick, Alvida and Helenius, Gisela and Lillsunde-Larsson, Gabriella}, year = {2025}, journal = {Scientific Reports}, volume = {15}, number = {1}, doi = {10.1038/s41598-024-84688-3}, url = {1926516}, language = {eng}, publisher = {Nature Publishing Group}, keywords = {comprehensive genetic profiling; hpv; vulvar squamous cell cancer}, abstract = {Vulvar cancer is a rare gynaecological disease that can be caused by infection with human papillomavirus (HPV). The mutational frequencies and landscape for HPV-associated and HPV-independent vulvar tumor development are supposedly two distinctly different pathways and more detailed knowledge on target biological mechanisms for individualized future treatments is needed. The study included formalin-fixed paraffin-embedded (FFPE) samples from 32 cancer patients (16 HPV-negative and 16 HPV-associated), treated in Örebro, Sweden from 1988 to 2008. The Oncomine™ Comprehensive Assay v3 was used to detect variants across 161 different tumor relevant genes. Data analysis included quality assessment followed by variant analysis of DNA with the Oncomine Comprehensive v3 workflow and with a custom filter using the VarSome Clinical software. The RNA-analysis was performed with the Oncomine Comprehensive v3 workflow. Totally, 94% of DNA libraries and 81% of RNA libraries were of adequate quality for further downstream analysis. With the Oncomine™ filter chain there was an increased number of variants in the HPV-negative group (2.5 variants) compared to the HPV-associated group (1.5 variants). Using custom filter and the Varsome Clinical software; additional single nucleotide variants (SNV) were detected where the vast majority were classified as likely benign/benign. HPV-negative tumors had a larger fraction of variants of unknown significance (VUS), and likely pathogenic/pathogenic compared to the HPV-associated tumours. The top 10 frequently mutated genes in HPV-indepentent tumors were TP53, POLE, PTCH1, BRCA2, CREBBP, NOTCH2, ARID1A, CDKN2A, MSH2, and NOTCH1. Three fusion genes were detected; TBL1XR1(1)::PIK3CA(2) (n = 2) and NF1(5)::PSMD11(2) (n = 1). Copy number variations (CNV) were more common in HPV-associated tumors (n = 13/16, 81%) compared to HPV-negative tumors (n = 9/14, 64%). The most frequent CNV was found in the cMYC gene, followed by CDK2 (n = 5) and CDK4 (n = 4). The main outcome of this study show that vulvar cancer harbour genetic variations of different types and specifically, HPV-independent tumours are molecularly very heterogeneous and harboured more SNVs while HPV-associated tumors more frequently presented with gene amplifications. The PI3K/AKT/mTOR1 pathway was affected in both the groups as well as the cell cycle regulation pathway. Similarly, the DNA repair gene POLE was found mutated in both vulvar cancer groups.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_titoccijessica_2025, title = {Pathways for converting zooplankton traits to ecological insights are paved with findable, accessible, interoperable, and reusable (FAIR) data practices}, author = {Titocci, Jessica and Pata, Patrick R. and Durazzano, Tiziana and Ayata, Sakina-Dorothée and Clerc, Corentin and Cornils, Astrid and Duffy, Patrick and Greer, Adam T. and Halsband, Claudia and Heneghan, Ryan F. and Lacoursière-Roussel, Anais and Lombard, Fabien and Majaneva, Sanna and Pakhomov, Evgeny A. and Reis, Carolina and Rist, Sinja and Rommel, Alix C. M. and Silva, Teresa and Stemmann, Lars and Ugwu, Kevin and Basset, Alberto and Rosati, Ilaria and Murphy, Kieran J. and Hunt, Brian P., V}, year = {2025}, journal = {ICES Journal of Marine Science}, volume = {82}, number = {2}, doi = {10.1093/icesjms/fsaf017}, url = {1944844}, language = {eng}, publisher = {Oxford University Press}, keywords = {trait; zooplankton; fair; trait-based approaches}, abstract = {The use of trait-based approaches and trait data in zooplankton ecology is rapidly growing to better understand and predict the patterns of zooplankton distributions and their role in aquatic ecosystems and biogeochemical cycles. Although the number of zooplankton trait-based studies and available trait datasets is increasing, several challenges remain for the findability, accessibility, interoperability, and reusability (FAIR) in trait-based approaches that, if unaddressed, may stifle progress in this research area. Here, we review recent applications of trait-based approaches in zooplankton research and summarize the currently available trait data resources. To realize the potential of trait-based approaches to resolve ecological roles of zooplankton, datasets and approaches must adhere to FAIR principles. We provide recommendations and pathways forward to ensure FAIRness while highlighting the importance of collaborative efforts. These practical and easily implementable strategies will enhance the FAIRness of trait data, ultimately advancing zooplankton ecological research and connecting these findings to aquatic ecosystem functioning.}, issn = {1054-3139} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hedbergsuzanne_2025, title = {Patient characteristics and perioperative outcomes in the Bypass Equipoise Sleeve Trial (BEST) compared to general metabolic bariatric practice in Sweden}, author = {Hedberg, Suzanne and Stenberg, Erik and Österberg, Johanna and Andersson, Ellen and Peltonen, Markku and Näslund, Erik and Neovius, Martin and Thorell, Anders and Olbers, Torsten and Ottosson, Johan}, year = {2025}, journal = {British Journal of Surgery}, volume = {112}, number = {10}, doi = {10.1093/bjs/znaf187}, url = {2005968}, language = {eng}, publisher = {Oxford University Press}, issn = {0007-1323} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lambertinimatteo_2025, title = {Patient perception on risk of recurrence and decision-making in the management of HER2-positive early breast cancer : Insights from the ASKHER2 European survey}, author = {Lambertini, Matteo and Jackisch, Christian and Trédan, Olivier and Vidal, Maria and Fontes-Sousa, Mário and Valachis, Antonis and D'Antona, Rosanna and Ruz, Marcelo and Krone, Eugenia and Brice, Miriam and Berjonneau, Erwan and Matos, Soraia and Dialla, Olivia and Guéroult-Accolas, Laure}, year = {2025}, journal = {The Breast}, volume = {81}, doi = {10.1016/j.breast.2025.104456}, url = {1948868}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {breast cancer; communication; decision making; her2+; intervention; patient perception; risk of recurrence}, abstract = {BACKGROUND: Perceived risk and fear of recurrence in patients with breast cancer (BC) is a matter of concern and may affect their health behaviours and their ability to participate in decision making during their treatment. This survey aimed to examine perceptions and concerns of patients with HER2+ BC.MATERIALS AND METHODS: A multi-country, non-interventional, direct-to-patient online survey was conducted between July 22, 2022 and March 1, 2023 in six European countries using a multi-modal recruitment approach.RESULTS: Out of 622 included patients, 96.8 % desired involvement in treatment decisions, and 58.5 % felt they had significant influence in the decision-making process. A total of 20.9 % of patients were unaware of their personal risk of recurrence, and 19.5 % reported not discussing this risk with their healthcare providers. The fear of disease recurrence, death, and treatment failure were identified as the most important concerns. Moreover, 30.4 % perceived they had clear communication with healthcare providers on risk of recurrence. A total of 64.5 % were willing to take extra treatments, 60.2 % to undergo more surgery to reduce recurrence risk and 68.5 % were willing to accept further treatments even if recurrence risk decreased by less than 50 %.CONCLUSION: Results of this multinational direct-to-patient study examining the perceptions and concerns of women with HER2+ breast cancer underscore the need for physicians to proactively involve patients in their decision-making process, enabling them to participate in a patient-centred approach during treatment decisions.}, issn = {0960-9776} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kristenseningrid_2025, title = {Patient reported fatigue after proton therapy for malignant brain tumours : Is there a relation between radiation dose and brain structures?}, author = {Kristensen, Ingrid and Langegård, Ulrica and Björk-Eriksson, Thomas and Blomstrand, Malin and Brodin, Patrik and Fransson, Per and Munck af Rosenschöld, Per and Nordström, Fredrik and Ohlsson-Nevo, Emma and Sjövall, Katarina and Ahlberg, Karin}, year = {2025}, journal = {Radiotherapy and Oncology}, volume = {202}, doi = {10.1016/j.radonc.2024.110582}, url = {1908090}, language = {eng}, publisher = {Elsevier}, keywords = {brain tumour; fatigue; proton therapy; quality of life}, abstract = {BACKGROUND: Fatigue may significantly effect everyday- and working life for radiotherapy patients. Some studies indicate a correlation between radiation dose and irradiated volume of the brain and the presence of fatigue. Our hypothesis was that patient reported outcome measures (PROMs) can improve our understanding of the patients' symptoms following proton beam therapy (PBT) and optimize PBT for future patients.METHODS: This study included 167 adult patients (>18 years) who received PBT for malignant brain tumours. Data on dose metrics to intra-cranial structures was obtained from PBT treatment plans. To explore fatigue and health related quality of life (HRQoL); Multidimensional Fatigue Inventory (MFI-20) and EORTC QLQ-C30 was used at 6-, 12-24- and 36 months post PBT. The correlation between fatigue and dosimetry was explored using Spearman's signed rank test.RESULTS: No severe fatigue was recorded during the 36 months follow-up. Correlations between higher radiation dose and worsened fatigue scores were generally weak (rho < 0.3). At 12 months post PBT, higher mean dose to the brain, brainstem, hippocampi and pituitary was correlated to worsened MFI Physical Fatigue. Further, Reduced Motivation according to MFI was correlated to higher radiation dose to the brainstem and the pituitary gland. At 36 months follow-up post-PBT, both Reduced Activity and Reduced motivation according to MFI were correlated to higher radiation dose to the brain, brainstem and hippocampi.CONCLUSION: Proton beam therapy are well tolerated, with similar degree of fatigue pre- and post PBT. Achieving further reduction in mean brain dose appears beneficial.}, issn = {0167-8140} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_elhajjvictorgabriel_2025_2, title = {Patient-centered care in cervical spine surgery - the impact of perceived patient involvement on patient-reported outcomes measures : a Swedish multicenter study}, author = {El-Hajj, Victor Gabriel and Gustafsson, Marcus Roland Victor and Vigren, Patrick and de Wilde, Daniel and Staartjes, Victor E. and Edström, Erik and Elmi-Terander, Adrian}, year = {2025}, journal = {European spine journal}, doi = {10.1007/s00586-025-09405-8}, url = {2006259}, language = {eng}, publisher = {Springer}, keywords = {spine surgery; patient involvement; shared decision-making; informed consent; registry}, abstract = {PURPOSE: Patient involvement and shared decision-making (SDM) are central to patient-centered care and have been linked to improved patient satisfaction and outcomes. However, their implementation in spinal surgery remains limited, and the effect of patient involvement on postoperative outcomes is not well described.METHODS: This observational cohort study used data from the Swedish Spine Registry (Swespine) to examine the association between perceived patient involvement in decision-making and postoperative outcomes among adults undergoing cervical spinal surgery between 2006 and 2020. Propensity score-matching was performed at a ratio of 2:1 to minimize baseline differences between groups. Uni- and multivariable analyses were conducted to identify factors associated with patient's perception of involvement in decision-making.RESULTS: A total of 3,249 patients were included, with 81% (n = 2,640) reporting perceived involvement in decision-making and 19% (n = 609) not. Following matching, patients who were involved in decision-making had significantly greater improvements at one year follow-up regarding neck and arm pain (p < 0.001), disability (p < 0.001), health-related quality of life (p < 0.001), and subjective satisfaction (p < 0.001). Patients with poorer preoperative health status are more likely to feel involved in decision making, while those undergoing minor procedures feel significantly less involved. Positive predictors of perceived patient involvement included number of operated levels (OR 1.13, p = 0.041), unemployment (OR 1.89, p < 0.001), walking less than 100 m at a normal pace (OR 1.45, p = 0.044), and higher preoperative NDI (OR 1.01, p = 0.039). Negative predictors included higher preoperative EQ-5D index (OR 0.64, p = 0.022) and higher preoperative myelopathy score (OR 0.96, p = 0.042).CONCLUSION: Patients with a higher degree of perceived involvement report better postoperative patient-reported outcomes following cervical spinal surgery. Patients undergoing larger surgeries and with poorer preoperative health status were more likely to perceive involvement than those undergoing minor procedures. Identifying and supporting patients that are susceptible to feel less involved in treatment-related decisions through individualized information or counseling may help optimize outcomes and satisfaction.}, issn = {0940-6719} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_westerdahlelisabeth_2025_1, title = {Patient-Reported Experiences of Home-Based Breathing Exercises After Cardiac Surgery : A Prospective Questionnaire-Based Cohort Study}, author = {Westerdahl, Elisabeth and Urell, Charlotte and Johansson, Henrik and Brocki, Barbara Cristina and Jonsson, Marcus}, year = {2025}, journal = {Journal of Patient Experience}, volume = {12}, doi = {10.1177/23743735251348849}, url = {1967859}, language = {eng}, publisher = {Sage Publications}, keywords = {breathing exercises; physical therapy; postoperative; rehabilitation; thoracic surgery}, abstract = {This study assessed patient-reported experiences and perceived respiratory outcomes of home-based deep breathing exercises 3 months after cardiac surgery. A postal questionnaire was sent to 120 patients at a Swedish university hospital, with 92 respondents (77%). The majority (89%) performed breathing exercises after discharge, with 77% reporting them as very easy to perform. Most patients continued the exercises for 2 to 4 weeks (41%) or 1 to 2 months (20%), typically practicing 3 times per day. The exercises were well tolerated, with 87% experiencing no discomfort. Motivation was generally high-43% felt very motivated, and 78% found the exercises useful. While chest pain was reported as low and 56% experienced improved breathing, nearly half of the respondents reported difficulties with coughing, and 10% sought medical care for respiratory infections. Overall, home-based deep breathing exercises were perceived as beneficial and well accepted. However, engagement and adherence varied, highlighting the need for tailored support to encourage sustained participation.}, issn = {2374-3735} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_elhajjvictorgabriel_2025_3, title = {Patient-reported outcome measures and satisfaction after laminectomy for degenerative cervical myelopathy in octogenarians : an observational study from the national Swedish spine registry}, author = {El-Hajj, Victor Gabriel and Staartjes, Victor E. and Charalampidis, Anastasios and Nilsson, Gunnar and Gerdhem, Paul and Edström, Erik and Elmi-Terander, Adrian and Åkerstedt, Josefin}, year = {2025}, journal = {European spine journal}, volume = {34}, number = {7}, pages = {3003--3011}, doi = {10.1007/s00586-025-08890-1}, url = {1957686}, language = {eng}, publisher = {Springer}, keywords = {degenerative spine disease; laminectomy; octogenarians; prom; spine surgery}, abstract = {BACKGROUND: Global demographics show a steady increase in the number of octogenarians. Consequently, the number of degenerative spine procedures in the elderly has significantly increased. This study aims to describe patient satisfaction, the patient-reported health-related quality-of-life, and complications, following posterior cervical laminectomy for degenerative cervical myelopathy (DCM) in octogenarians based on the national Swedish experience.METHODS: The national Swedish spine registry, Swespine was reviewed between January 2006 and December 2020 for patients who underwent laminectomy for DCM. Complication rates, patient satisfaction, and Patient-Reported Outcome Measures (PROMs) one year after surgery, were analyzed and compared between propensity score matched octogenarian (≥ 80) and younger adult cohorts (< 80 years).RESULTS: A total of 1,382 patients, 162 octogenarians, and 1,220 younger patients were identified. At one-year after surgery there were no significant difference in patient satisfaction rate or in any of the other PROMS (Eq. 5D, NRS neck pain, NRS arm pain, EQ-VAS, Neck Disability Index (NDI), the European Myelopathy Score (EMS). Complication rates were also comparable, 8.0% in octogenarians (n = 13) and 11% in younger adults (n = 51), respectively. The length of hospital stay was significantly longer in the octogenarian group, with a mean hospitalization of 5.08 days (SD ± 4.86) compared to 3.76 days (SD ± 3.93) in the younger adult cohort (p < 0.001).CONCLUSIONS: Octogenarians undergoing cervical spine surgery for DCM experience outcomes comparable to younger adults in terms of satisfaction, pain relief, and quality of life, indicating that age alone should not hinder surgical treatment.LEVEL OF EVIDENCE: IV, Retrospective observational cohort study.}, issn = {0940-6719} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hofmanhannelore_2025, title = {Patients’ experiences with the application of medical adhesives to the skin : a qualitative systematic review}, author = {Hofman, Hannelore and Duljic, Tanja and Johansson, Sara and Kottner, Jan and Kinnaer, Lise-Marie and Eriksson, Mats and Beeckman, Dimitri}, year = {2025}, url = {2002229}, language = {eng}, keywords = {medical adhesive; pain; systematic review}, abstract = {IntroductionPressure ulcer treatment usually involves the application of wound dressings, some of which are affixed to the skin with medical adhesives. Medical adhesives provide securement of medical devices, facilitate skin protection and allow non-invasive monitoring. Application and removal of medical adhesives can result in pain, dermatitis, trauma or other skin lesions. Understanding patients’ experiences when subjected to medical adhesives will contribute to the improvement of clinical routines and the development and improvement of new adhesive technologies. A qualitative systematic review was conducted to identify patients’ experiences with the application of medical adhesives to the skin.MethodsCINAHL, EMBASE, MEDLINE and PsycINFO were systematically searched for records published between January 2012 and March 2024. Reference lists of systematic reviews and included articles were reviewed. Studies published in Danish, Dutch, English, German, Norwegian and Swedish that collected qualitative data on the experience of patients with the application of medical adhesives to the skin were considered. Therewere no restrictions regarding age, gender or setting. Study selection, data extraction and quality appraisal were independently conducted by two reviewers. The methodological quality of the studies under consideration was assessed using the Joanna Briggs Institute Critical Appraisal Tool for Qualitative Research. The extracted data were synthesised using meta-aggregation.ResultsNine studies describing patients’ experiences were included. The included studies only reflected experiences with wound dressings. Meta-aggregation of the extracted findings resulted in seven categories that were further synthesised into two synthesised findings: ‘strategies to alleviate pain during dressing changes’ and ‘dressing construction and characteristics’. The synthesised findings illustrate that patients experience pain during dressing change and removal and employ various strategies to alleviate this pain.ConclusionsPatients experience pain and discomfort when dressings are changed or removed. Future research should focus on enhancing both routines and technologies, with a particular emphasis on advancing skin-friendly adhesives to reduce unwanted side effects.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ohlssonnevoemma_2025, title = {Patients' transition experience of centralized cancer surgery in Sweden, according to the Transition Theory by Meleis}, author = {Ohlsson-Nevo, Emma and Höglund, Erik}, year = {2025}, journal = {British Journal of Surgery}, volume = {112}, number = {Suppl. 11}, pages = {xi34--xi35}, doi = {10.1093/bjs/znaf149.124}, url = {1992697}, language = {eng}, publisher = {Oxford University Press}, abstract = {Introduction: Advanced cancer surgery has been centralized according to the Sweden National Specialised Medical Care system. Knowledge about how patients experience having surgery far from home is lacking.The aim was to describe the transition experience of elective cancer surgery within the National Specialised Medical Care, including the recovery at the local hospital and returning home.Method: Individual interviews was conducted with 20 patients who had undergone cancer surgery between the years 2016 – 2023. The Meleis' Transition Theory was the theoretical framework and content analysis the metod used.Result: Being fortunate: Being part of the centralized cancer surgery was perceived as an opportunity, which gave hope for a greater chance of survival.Being alone: The patients found it difficult to be alone, and away from their family. Loneliness was perceived to have a negative impact on recovery.Having to adapt to the system: Patients had no choice but to trust the system. The healthcare system was not always perceived to consider the patient's individual needs.A need for personal engagement: Communication and coordination within and between the hospitals, was perceived as inadequate. Some patients felt that they needed to organise their own examinations, surgery, and return appointments.Discussion: Established and well-functioning communication and coordination channels between patient and caregiver are important for a well-functioning system. Care needs to be organised in accordance with the needs and wishes of patients. Staff at all relevant units need to have knowledge of the complexity of the surgery to understand the transition experience and the patient's unique needs.}, issn = {0007-1323} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_reitsemarosanned_2025, title = {Patients with peripheral artery disease demonstrate altered expression of soluble and membrane-bound immune checkpoints}, author = {Reitsema, Rosanne D. and Kurt, Seta and Rangel, Ignacio and Hjelmqvist, Hans and Dreifaldt, Mats and Sirsjö, Allan and Kumawat, Ashok Kumar}, year = {2025}, journal = {Frontiers in Immunology}, volume = {16}, doi = {10.3389/fimmu.2025.1568431}, url = {1990474}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {t cells; antigen presenting cells; immune checkpoints; intermittent claudication; peripheral artery disease}, abstract = {INTRODUCTION: Studies suggest that immune checkpoints play a role in accelerating the formation of atherosclerosis. We aimed to assess the expression of soluble and membrane-bound immune checkpoints in patients with peripheral artery disease (PAD).METHODS: The levels of 14 soluble immune checkpoints were assessed in blood plasma of PAD patients (n= 37) and healthy controls (HCs, n=39) by Multiplex protein assay. The surface expression of immune checkpoints on peripheral blood immune cells was determined by flow cytometry. Cytokine production capacity was measured by flow cytometry in TIM-3+ T cells to determine immune exhaustion.RESULTS: Soluble levels of PD-L2 were decreased in female PAD patients, whereas soluble levels of TIM-3 showed a trend towards an increased concentration in female PAD patients. PD-L2+ frequencies were higher within all monocyte subsets in PAD patients. CD4+ T cells from PAD patients had increased frequencies of TIM-3+ cells, showing little overlap with other immune exhaustion markers. TIM-3+ CD4+ T cells from both PAD patients and HCs, had a low capacity to produce pro-inflammatory cytokines, but a higher capacity to produce IL-10 compared to TIM-3- CD4+ T cells.CONCLUSION: PAD patients show differences in the expression of membrane-bound and soluble immune checkpoints. Some of these differences might be caused by prolonged immune activation, although immune exhaustion markers did not always overlap.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_hearnjeff_2025_6, title = {Patriarchy}, author = {Hearn, Jeff}, year = {2025}, pages = {359--362}, doi = {10.4337/9781803922065.ch107}, url = {1938760}, language = {eng}, publisher = {Edward Elgar Publishing}, keywords = {fathers; fratriarchy; masculinities; men; patriarchy; transpatriarchies}, abstract = {This entry outlines definitions of and debates on patriarchy, ranging from the ‘rule of the fathers’ to a diverse range of broader feminist theorizations in terms of, for example, the domestic mode of production, economic systems, reproduction, sexuality, and violence. This is followed by noting some critiques of the concept of patriarchy as, for example, too monolithic, ahistorical or insufficiently intersectional, as well as how patriarchy has become important as a critical frame in some theorizations of masculinities. These discussions feed into the consideration of several ways in which patriarchy, as both concept and social formation, are relevant for analyses of management. These include: patriarchy as a context of management; the management of patriarchal arenas, such as the state and capitalist organizations; and management as a manifestation of patriarchy. More specifically, attention is drawn to the practices of patriarchal managements, patriarchal managing, and patriarchal masculinities; and the increasing recognition of plural, intersectional and transnational patriarchal managements.}, file = {https://oru.diva-portal.org/smash/get/diva2:1938760/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sanchodomingoclara_2025, title = {Patterns of Caffeine Use in Adolescents and Their Association with Sleep Quality : A Latent Class Analysis}, author = {Sancho-Domingo, Clara and Garmy, Pernilla and Norell, Annika}, year = {2025}, journal = {Journal on Addictions Nursing}, doi = {10.1097/JAN.0000000000000651}, url = {1997074}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, keywords = {adolescents; caffeine use; coffee; energy drinks; latent class analysis; sleep quality}, abstract = {BACKGROUND: Although there is substantial evidence of the negative impact of caffeine use on sleep quality, few studies focus specifically on adolescents' patterns of use. This study aimed to identify patterns of caffeine use among adolescents and analyze their association with sleep quality.METHOD: A cross-sectional study was conducted in southern Sweden including 1,404 adolescents aged 15-17 (56.3% girls). The frequency of use for coffee, tea, and energy drinks was evaluated, as well as the quality of sleep and its dimensions. Latent class analysis and multivariate analyses were conducted.RESULTS: The weekly prevalence of caffeine use in adolescents reached 85% (n = 1189), with 40% (n = 559) drinking almost every day. Three caffeine-using patterns were identified: low probability caffeine use (28.1%; n = 393) characterized by sporadic use of coffee/tea, caffeinated soda use (55.2%; n = 784) related to high soda weekly consumption, and mixed caffeine use (16.7%; n = 227) that includes drinking diverse caffeine products almost every day including soda and energy drinks. Mixed caffeine pattern was associated to worse sleep followed by the soda pattern (p < .05), with significant differences observed in difficulties falling asleep (OR = 1.4; 95% CI = 1.1-1.7) or waking up (OR = 1.8; 95% CI = 1.4-2.4), greater daytime dysfunction (OR = 1.3; 95% CI = 1.1-1.7), and shorter sleep duration on schooldays (OR = 1.9; 95% CI = 1.5-2.4).CONCLUSION: Distinct severity levels were found for caffeine use patterns among adolescents based on their association with sleep quality. Findings emphasize the need for addressing caffeine misuse among adolescents to promote health and adequate sleep habits in the transition to adulthood.}, issn = {1088-4602} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hamedabedalazizulfet_2025, title = {Pedagogiska verktyg för interprofessionellt lärande i klinisk handledarutbildning : en ny kurs vid Örebro universitet}, author = {Hamed Abed-Alaziz, Ulfet and Hedenskog, Christina and Södergren, Torbjörn and Hellgren, Mikko}, year = {2025}, url = {1962150}, language = {swe}, abstract = {Våren 2024 fick handledare vid Örebro universitet och Region Örebro län i uppdrag att skapa en ny högskolepoänggivande kurs i klinisk handledning, som sedan startade under höstterminen 2024. Kursens målgrupp är kliniker inom vårdprofessioner som utbildar studenter på grund- och avancerad nivå vid Örebro universitet, eller utbildar ST-läkare.Förutom att ge färdigheter och förmågor inom klinisk handledning så syftar kursen också till att stärka deltagarnas interprofessionella handledarskap. Exempel på pedagogiska verktyg som används i syfte att stärka det interprofessionella handledarskapet är:Lärare från olika professioner samverkar med varandra under varje undervisningsmoment.Lärare från flera vårdprofessioner är representerade.Kursen utnyttjar kliniska erfarenheter inom respektive profession men undervisningen innehåll är generellt för klinisk handledning.Deltagare från olika professioner blandas i grupparbeten och i rummet.Vid bikupor lyfts erfarenheter från olika professioner fram och deltagarna besvarar frågor utifrån respektive profession.En vetenskaplig artikel om interprofessionell handledning inläses som förberedelse, med reflektioner kring hur deltagarna bäst kan samverka interprofessionellt.Den här postern visar hur vi lärare har använt olika verktyg för att lyfta fram visionen om att stärka ett interprofessionellt handledarskap utan att kompromissa med kursens övriga mål. Vi tror att interprofessionella aspekter på handledningsfrågor är särskilt viktiga när kurser ges med deltagare från olika vårdprofessioner och där en del av kursens pedagogik syftar till att reflektera kring och dela med sig av sina egna professionserfarenheter i handledarskapet.}, file = {https://oru.diva-portal.org/smash/get/diva2:1962150/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hagstrmjosefin_2025, title = {Pediatric oncology healthcare professionals' attitudes to and awareness of regulations for minors' and guardians' online record access : a mixed-methods study in Sweden}, author = {Hagström, Josefin and Blease, Charlotte and Harila, Arja and Scandurra, Isabella and Lähteenmäki, Päivi and Hägglund, Maria}, year = {2025}, journal = {BMC Health Services Research}, volume = {25}, number = {1}, doi = {10.1186/s12913-025-13697-3}, url = {2017590}, language = {eng}, publisher = {Springer}, keywords = {adolescent health; adolescents; ehealth; electronic health record (ehr); healthcare professionals (hcps); interviews; oncology; patient accessible electronic health record (paehr); patient portal; survey}, abstract = {BACKGROUND: Healthcare providers and policymakers worldwide differ in their provision of access to adolescent patients' electronic health records (EHR). The regulatory framework in Sweden restricting both guardians' and adolescents' online record access (ORA) has during recent years received criticism. The aim was to quantitatively and qualitatively, explore attitudes about ORA and perceptions about ORA regulations among pediatric oncology healthcare professionals (HCPs) in Sweden.METHODS: A convergent mixed-methods design (QUAL, quan) was used, consisting of a survey study (N = 95) and semi-structured individual interviews (N = 13). Physicians and nurses in pediatric oncology were recruited in clinics face-to-face or via staff e-mail. Descriptive statistics were used to present quantitative survey results. Interviews were recorded, transcribed, and analyzed using content analysis.RESULTS: A majority of participants (72%) were critical of the access restrictions but lacked knowledge about access extensions, with more than 60% unaware of application procedures. Five themes emerged regarding both perceived benefits and risks of ORA. Examples of benefits included adolescent empowerment, parental support, and improved partnership; risks included an increased emotional distress and confusion among young patients and their guardians, increased workload for HCPs, and threats to adolescent confidentiality. An additional five identified themes captured HCPs' views on regulations and included uncertainty, variation among adolescents, and the need to balance parental support and adolescent privacy.CONCLUSIONS: Findings indicate lacking knowledge about ORA regulations and little incentive for HCPs to promote its use. While risks of ORA were often directly experienced and concerned confidentiality breaches and difficulties with EHR documentation, benefits tended to be anticipatory and related to patient or parent experiences. Still, HCPs showed limited support for ORA restrictions during adolescence. To ensure safe and effective ORA use, HCPs need clearer guidance and support.TRIAL REGISTRATION: Not applicable.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_nieh_2025, title = {Peekaboo, I See Your Queries : Passive Attacks Against DSSE Via Intermittent Observations}, author = {Nie, H. and Wang, W. and Xu, P. and Chen, W. and Yang, L.T. and Conti, Mauro and Liang, K.}, year = {2025}, pages = {2429--2443}, doi = {10.1145/3719027.3765075}, url = {2028604}, language = {eng}, publisher = {Association for Computing Machinery, Inc}, keywords = {dynamic searchable symmetric encryption; intermittent-observation attacker; leakage abuse attacks}, abstract = {Dynamic Searchable Symmetric Encryption (DSSE) allows secure searches over a dynamic encrypted database but suffers from inherent information leakage. Existing passive attacks against DSSE rely on persistent leakage monitoring to infer leakage patterns, whereas this work targets intermittent observation - a more practical threat model. We propose Peekaboo - a new universal attack framework - and the core design relies on inferring the search pattern and further combining it with auxiliary knowledge and other leakage. We instantiate Peekaboo over the SOTA attacks, Sap (USENIX' 21) and Jigsaw (USENIX' 24), to derive their “+” variants (Sap+ and Jigsaw+). Extensive experiments demonstrate that our design achieves >0.9 adjusted rand index for search pattern recovery and ~90% query accuracy vs. FMA's ~30% (CCS' 23). Peekaboo's accuracy scales with observation rounds and the number of observed queries but also it resists SOTA countermeasures, with >40% accuracy against file size padding and >80% against obfuscation. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_petersonhelen_2025_1, title = {Peer review across borders : benefits and challenges of international review panels in research funding organizations}, author = {Peterson, Helen and Husu, Liisa}, year = {2025}, journal = {Research Evaluation}, volume = {34}, doi = {10.1093/reseval/rvaf030}, url = {1985477}, language = {eng}, publisher = {Oxford University Press}, keywords = {peer review; research funding organisations; international review panels; research evaluation; calibration; inter-reviewer reliability; conflict of interest}, abstract = {Peer review by external experts is widely recognized as a legitimate and trustworthy academic practice, essential for ensuring the quality and rigor of research, providing more objective and less impartial assessments, and promoting transparent decision-making in science and academia. Research Funding Organisations (RFOs) usually rely on some form of peer review to evaluate the scientific quality of research proposals to allocate their limited resources. The peer review system is, however, also associated with several weaknesses, such as risks for bias and conflict of interest. This article explores the implications of replacing National Review Panels (NRPs) with International Review Panels (IRPs) in a national RFO, examining how this shift may impact the peer review process. Drawing on semi-structured interviews with staff from a national RFO in a European country and members of its IRPs, the article provides a nuanced analysis of both the potential benefits and challenges with substituting NRPs with IRPs. The results highlight how IRPs increase the distance between applicants and reviewers, which benefits the impartiality of the process. Nevertheless, this distance needs to be balanced by domestic panel members, chairs or research officers possessing appropriate knowledge of the local academic context, culture and structure. IRPs also introduce a greater diversity of perspectives into the assessments of applicants, which may promote objective and balanced assessments. The diversity may however also lower inter-reviewer reliability, and, in turn, complicate calibration practices and hinder the development of informal deliberative norms during the process of reaching decisions and consensus.}, issn = {0958-2029} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gattariokristinaholmqvist_2025, title = {Peer victimization and peer sexual harassment across early adolescence : Branches from the same tree or free-standing constructs?}, author = {Gattario, Kristina Holmqvist and Valik, Andrea and Lunde, Carolina and Skoog, Therése and Jaf, Darun}, year = {2025}, journal = {Journal of research on adolescence}, volume = {35}, number = {4}, doi = {10.1111/jora.70079}, url = {2003824}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {early adolescence; exploratory structural equation modeling; peer sexual harassment; peer victimization}, abstract = {Researchers have debated whether peer victimization and peer sexual harassment (PSH) are branches from the same tree and/or whether they are different constructs; yet no previous study has been able to clarify this issue. We used exploratory structural equation modeling to examine three different, theoretically informed ways of conceptualizing peer victimization and PSH. Annual three-wave questionnaire data included 997 participants at T1 (M age = 10.0 years, SD = 0.3). Results indicated that peer victimization and PSH should best be viewed as two distinct, yet related constructs - a proposition valid across both time (ages 10-12) and genders. The findings from the present study can inform future research on adolescents' adverse peer experiences.}, issn = {1050-8392} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_mohammedomard_2025_2, title = {Pendulum-based mechanism for energy harvesting from automobile movement}, author = {Mohammed, Omar D. and Al-Muneef, Haleerna and Alherz, Hala and Amsseri, Fatima and Alforehe, Jalilah and Al-Dossary, Wafa}, year = {2025}, volume = {57}, doi = {10.1121/2.0002067}, url = {1998716}, language = {eng}, publisher = {Acoustical Society of America (ASA)}, abstract = {With the increasing demand for sustainable and auxiliary energy solutions, innovative energy harvesting techniques are gaining more traction. This study explores the application of a pendulum-based energy harvesting mechanism in vehicles, utilizing the natural oscillations induced by vehicle movement to generate electrical power. In the current article, a pendulum-based mechanism is developed for energy generation in vehicle applications. The article presents theoretical analyses of motion dynamics, energy conversion efficiency, and system integration feasibility. The developed mechanism is designed for vehicle applications to be excited by car motion. The calculation results indicate the applicability and how effective the developed mechanism is. The proposed design should be fabricated in a small size and lightweight to be installed in the back trunk of the car or other parts where it can be fixed, preferably close to the suspension system, to have higher excitation.}, file = {https://oru.diva-portal.org/smash/get/diva2:1998716/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_cewepaulina_2025_2, title = {Penetrating extremity injuries in a large Scandinavian Level-1 trauma center : a 4-year analysis of imaging methods, mechanisms of injury and clinical outcome}, author = {Cewe, Paulina and Thorisdottir, Sigurveig and Oladottir, Gudrun L. and El-Hajj, Victor Gabriel and Staartjes, Victor E. and Elmi-Terander, Adrian and Koskinen, Seppo K. and Edström, Erik}, year = {2025}, journal = {European Journal of Orthopaedic Surgery & Traumatology}, volume = {35}, number = {1}, doi = {10.1007/s00590-025-04507-x}, url = {1997168}, language = {eng}, publisher = {Springer-Verlag France}, keywords = {angiography; ct; extremities; imaging; injuries; penetrating; trauma; vascular}, abstract = {BACKGROUND: To analyze penetrating extremity injuries at a Scandinavian urban Level-1 trauma center regarding incidence, mechanism of injury, imaging approach and clinical outcome.METHODS: A retrospective study (2013-2016) of penetrating injuries to the extremities based on a Trauma Registry. Retrieved variables included patient demographics, injury characteristics, time to CT and 30-day morbidity.RESULTS: Of 636 patients with penetrating trauma, 142 (22.3%) sustained injuries to the extremities that required imaging, surgical treatment, or observation. Median age was 25 years (15-83) and consisted mostly of males (90.8%, 129/142). Most were Level-1 trauma, 81.7%, with 28.9% multi trauma. Most common injuries were gunshot wounds (GSW, 47.9%) and stab wounds (SW, 47.2%), and lower extremities were most common (77.8%). Imaging showing arterial injury was present in 31.0%. %. CT-angiography was the most common modality 65.5% (93/142) and had excellent sensitivity for vascular injury of 100%. More than half of CTAs were negative: 60.4% in GSW compared to 53.7% in SW. GSWs were 7.4-times likelier to necessitate acute surgery compared to SWs (p = 0.0001). Surgery requiring vascular repair consisted of 19.0% and was more common in GSW 11.3% compared to SW 6.3%. Fasciotomy was performed in 5.6% of all GSW. In 1.4% there was loss of limb. The 30-day morbidity rate was 16.2%, mortality was 0%. Overall, GSW increased the odds for 30-day complications, compared to SW (Odds-ratio = 14.1, p < 0.001).CONCLUSIONS: In a Scandinavian Level-1 Trauma Center, about every fourth to fifth admission for penetrating trauma involved penetrating extremity injuries. GSWs had a significantly higher probability for acute surgery, and higher rate of 30-day complications. The rate of arterial injury was around one third of all injuries. CTA is effective and sensitive in detecting clinically relevant vascular injuries. Half of CTAs were negative. Stratifying patients into exam-based indication for CTA is important to reduce unnecessary imaging.}, issn = {1633-8065} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_edvinssonrodney_2025, title = {Penningmängdstillväxtens prognosförmåga för inflationen i Sverige skattad på data över fyra århundraden}, author = {Edvinsson, Rodney and Karlsson, Sune and Österholm, Pär}, year = {2025}, journal = {Ekonomisk Debatt}, volume = {53}, number = {7}, pages = {43--53}, url = {2014023}, language = {swe}, publisher = {Nationalekonomiska Föreningen}, issn = {0345-2646} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_whlincharlotte_2025, title = {Perceived health, musculoskeletal disorders, work conditions and safety climate in relation to patient handling and movement - a multicentre cross-sectional study at healthcare workplaces}, author = {Wåhlin, Charlotte and Sandqvist, Jan and Enthoven, Paul and Buck, Sebastian and Karlsson, Nadine and Nilsing Strid, Emma}, year = {2025}, journal = {BMC Musculoskeletal Disorders}, volume = {26}, number = {1}, doi = {10.1186/s12891-025-09330-3}, url = {2014079}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {ergonomics; health personnel workers; occupational health; safety culture; safety management; work-related musculoskeletal disorders; working environment}, abstract = {BACKGROUND: A safe healthcare work environment is essential to promote patient safety and healthcare workers' (HCWs) well-being. Nevertheless, musculoskeletal disorders (MSDs) remain highly prevalent, particularly in relation to patient handling and movement (PHM). This study aims to describe and compare HCWs health, MSDs, working conditions, and safety climate in relation to PHM in hospital care units and nursing homes, as well as to identify desired workplace improvements.METHODS: This multicentre cross-sectional study was based on data collected in 2023 as part of a prospective cluster-randomized trial conducted in Sweden. In total, 1,214 HCWs in 17 hospital care units and 27 nursing homes completed a questionnaire assessing health, PHM routines, organizational conditions, and safety climate using the NOSACQ-50 instrument. Factor analyses of PHM and work environment variables informed mixed linear regression models, evaluating associations with perceived safety climate. Qualitative content analysis was performed on open-ended responses regarding desired workplace improvements.RESULTS: MSDs were highly prevalent, with 79% of HCWs reporting symptoms in the past week. Nursing home HCWs experienced more pain sites, particularly in extremities. Compared to nursing home HCWs, hospital care HCWs more frequently disagreed that PHM activities were guided by clear policies, written guidelines, established routines, or regular training (p < 0.001). Hospital HCWs demonstrated lower adherence to safety policies and less systematic risk assessment. Despite these challenges, the overall perceived safety climate was moderately positive, with NOSACQ-50 mean scores ranging from 3.1 to 3.6. Over 40% of HCWs reported significant physical work environment issues, including heavy lifting, repetitive movements, uncomfortable positions, and high work pace. Regression analyses revealed that organizational support, clear guidelines, ergonomic and psychosocial work factors, and especially managerial support (p < 0.001), were strongly associated with higher perceived safety climate. Qualitative data mostly underscored needs for improved staffing, education, structured routines, and better access to assistive equipment, particularly ceiling lifts.CONCLUSIONS: Substantial physical and organizational challenges related to PHM were reported by HCWs across both care contexts. The findings suggest that interventions emphasizing leadership engagement, a systematic approach to training, and tailored solutions are essential to strengthen the safety climate and reduce HCWs' health risks.TRIAL REGISTRATION: NCT05276180 Registration date 02112022.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_taitimariachiara_2025, title = {Perceived parental prejudice and a tolerant class context in ethnic bullying : The buffering role of teachers}, author = {Taiti, Maria Chiara and Palladino, Benedetta Emanuela and Stefanelli, Federica and Bayram Özdemir, Sevgi and Menesini, Ersilia}, year = {2025}, journal = {Journal of Adolescence}, volume = {97}, number = {2}, pages = {514--525}, doi = {10.1002/jad.12437}, url = {1907520}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {classmates’ tolerance; ethnic bullying; perceived parental prejudice; teachers’ tolerance}, abstract = {Introduction: Despite recent efforts to understand the possible impact of contextual factors on adolescents’ involvement in ethnic bullying, most existing studies have focused on the effects of one context at a time. As adolescents are simultaneously exposed to the influence of multiple socialization agents, the aim of this study was to investigate whether teachers’ and classmates’ tolerance towards ethnic minorities could buffer the effect of perceived parental prejudice on adolescents’ involvement in ethnic bullying.Methods: Data were collected between January and February 2020 from 9th grade adolescents (N = 582; Mage = 15.23; SD = 0.65; 50.9% female; 30.7% with an immigrant background), and their teachers (N = 72; aged between 27 and 65 years; 79% female), belonging to 37 classrooms located in Italy.Results: A cross‐sectional multilevel analysis showed that teachers’ tolerance mod-erated the effect of perceived parental prejudice on adolescents’ involvement in ethnic bullying. Specifically, we found that in classrooms with low levels of teachers’ tolerance, perceived parental prejudice was significantly associated with students’ involvement in ethnic bullying. Conversely, in classrooms with high levels of teachers’ tolerance, parental prejudice was no longer associated with ethnic bullying. Furthermore, classmates’ tolerance was not significantly associated with students’ involvement in ethnic bullying and did not moderate the association between perceived parental prejudice and adolescents’ engagement in ethnic bullying.Conclusions: Findings are discussed highlighting the important role of school as a context to promote positive multicultural relations and the unique role played by teachers in affecting adolescents’ behaviors.}, issn = {0140-1971} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jildenstlpether_2025, title = {Perceptions of eHealth and digitalization among professional anaesthesia personnel : A Swedish national study}, author = {Jildenstål, Pether and Viseu, Camilla and Hermander, Kristian and Sjöberg, Carina and Hallén, Katarina and Schnorbus, Randolph and Augustinsson, Annelie}, year = {2025}, journal = {Acta Anaesthesiologica Scandinavica}, volume = {69}, number = {3}, doi = {10.1111/aas.14587}, url = {1935242}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {anaesthesia; digitalization; ehealth}, abstract = {BACKGROUND: The objective of this study was to evaluate anaesthesia care professionals' perceptions and attitudes regarding the implementation and advancement of digital solutions in perioperative care.METHODS: Anaesthesia personnel working in public Swedish institutions where anaesthesia is administered were invited to respond to an online survey regarding their attitudes towards digitalization in the workplace and their perceptions of information provision and future digitalization within anaesthesia and surgical healthcare. Data were analyzed using descriptive statistics, independent-samples Kruskal-Wallis tests, and post-hoc pairwise comparisons.RESULTS: The survey response rate was 64.0% (n = 627). Most respondents agreed/strongly agreed that digital solutions facilitate their work, the preoperative preparation, patient participation, and being involved in the patients' journeys throughout the perioperative care process. The majority also agreed/strongly agreed that digital solutions could make more patients adequately prepared before anaesthesia/surgery, reduce the number of non-optimized patients, and adapt the perioperative process to the patients' individual needs, as well as lead to reduced costs for the healthcare provider and reduced cancelled anaesthesia/surgeries. However, there were statistically significant differences between responses in relation to age groups, where the largest differences were observed between respondents in the age groups 20-30 and 61-70 years and in relation to what part of Sweden respondents worked in, with the largest differences between respondents working in Southern Sweden and the middle part of Sweden.CONCLUSION: Swedish anaesthesia personnel are confident that digital solutions may enhance the efficiency of care within the anaesthesia setting. However, varying perceptions on the benefits and necessity of digital solutions are indicated.}, issn = {0001-5172} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lacerdafranciscamirianmoura_2025, title = {Perceptions of plant-based meat among Brazilian consumers}, author = {Lacerda, Francisca Mirian Moura and Baptista, Iuri Yudi Furukita and Behrens, Jorge Herman}, year = {2025}, journal = {Ciência Rural}, volume = {55}, number = {9}, doi = {10.1590/0103-8478cr20240460}, url = {1986413}, language = {eng}, publisher = {Universidade Federal de Santa Maria}, keywords = {consumer science; word association; sustainability; protein transition; sociodemographic}, abstract = {This study explored the perceptions of plant-based meat among different socio and demographic segments of Brazilian consumers. The research included 763 participants, predominantly women, living in urban areas and with a high level of education. The analysis revealed that income, education, and age significantly affect perceptions of these products. Lower-income consumers often view plant-based meat as expensive and inaccessible, while those with higher purchasing power value its quality and convenience, indicating a greater propensity for adoption, particularly when aligned with ethical and health concerns. Education emerged as a key factor, with more educated individuals demonstrating greater awareness of the benefits. The word association task highlighted diverse perceptions: positive terms such as 'sustainable' and 'healthy' reflect appreciation, while negative terms like 'fake' and 'industrialized' expose skepticism. The study concluded that the acceptance of plant-based meat in Brazil is influenced by multiple factors and calls for tailored strategies to enhance accessibility, address consumer concerns, and promote culturally relevant solutions for more sustainable diets.}, issn = {0103-8478} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kittangjeanette_2025, title = {Perceptions of quality of care in oncological outpatient settings : a qualitative study of healthcare professionals}, author = {Kittang, Jeanette and Ohlsson-Nevo, Emma and Schröder, Agneta and Arnell, Susann}, year = {2025}, journal = {BMJ Open}, volume = {15}, number = {9}, doi = {10.1136/bmjopen-2025-102950}, url = {1999234}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {delivery of health care; integrated; nursing care; oncology; qualitative research; quality in health care}, abstract = {OBJECTIVES: To explore and describe how healthcare professionals within the oncological outpatient setting perceive quality of care.DESIGN: A qualitative, descriptive design with a phenomenographic approach was used, with focus group discussions as the means of data collection.SETTING: Primary care in oncological outpatient units in four hospitals in Sweden.PARTICIPANTS: Through purposive sampling, 20 healthcare professionals entered and completed the study by participating in four focus groups, five participants in each group. Inclusion criteria were assistant nurses, nurses or physicians delivering treatment and care with radiation and/or anticancer drugs in oncological outpatient units. Excluded were healthcare professionals who had worked less than 3 months at the oncological outpatient unit.RESULTS: Two descriptive categories emerged from the data: 'The professional's personal ability for good care' and 'The structural conditions for good care'. These categories consist of descriptions of quality of care being perceived as a good meeting with patients, patient participation, continuity, accessibility and care grounded in science.CONCLUSIONS: According to the healthcare professionals, quality of care relies on organisational structures in combination with a professional and personal interaction between the patients and the healthcare professionals. Knowledge about what healthcare professionals believe constitutes quality of care should therefore be highly valuable to policymakers and hospital management.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_novakazifjoll_2025_1, title = {Perception's Role for Mental Model Formation in Automated Driving : Insights From Four Studies}, author = {Novakazi, Fjollë}, year = {2025}, journal = {Journal of Cognitive Engineering and Decision Making}, volume = {19}, number = {4}, pages = {420--452}, doi = {10.1177/15553434251334409}, url = {1956534}, language = {eng}, publisher = {Sage Publications}, keywords = {automation; driving automation; mental model; perception; human-centric design; empirical studies}, abstract = {The rapid development of driving automation systems (DAS) in the automotive industry aims to support drivers by automating longitudinal and lateral vehicle control. As vehicle complexity increases, it is crucial that drivers comprehend their responsibilities and the limitations of these systems. This work investigates the role of the driver's perception for the understanding of DAS by cross-analysing four empirical studies. Study I investigated DAS usage across different driving contexts via an online survey conducted in Germany, Spain, China, and the United States. Study II explored contextual DAS usage and the factors influencing drivers' understanding through a Naturalistic Driving Study (NDS), followed by in-depth interviews. Study III employed a Wizard-of-Oz on-road driving study to simulate a vehicle offering Level 2 and Level 4 DAS, paired with pre- and post-driving interviews. Study IV following up used a Wizard-of-Oz on-road driving study to simulate Level 2 and Level 3 DAS and subsequent in-depth interviews. The findings from these studies allowed the identification of aspects constituting a driver's understanding and factors influencing their perception of DAS. The identified aspects and factors were consolidated into a unified conceptual model, describing the process of how perception shapes the driver's mental model of a driving automation system.}, issn = {1555-3434} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hopekjell_2025, title = {Perfluorinated alkyl acids in surface and deep water from the Western Indian Ocean : A comparison with global data}, author = {Hope, Kjell and Baabish, Abeer and Bouwman, Hindrik and van Aswegen, Jan Daniël and Fiedler, Heidelore}, year = {2025}, journal = {Science of the Total Environment}, volume = {1001}, doi = {10.1016/j.scitotenv.2025.180386}, url = {1999668}, language = {eng}, publisher = {Elsevier}, keywords = {deep sea; manmade substances; marine pollution; pfas analysis; persistent organic pollutants}, abstract = {This paper offers a comparative analysis of perfluoroalkyl substances (PFAS) in oceans and freshwater systems. Included are surface water and deep-water samples to provide a snapshot of the occurrence of these substances in a global context. Emphasis is given to the Western Indian Ocean (WIO), which has unique features due to a large land mass at low latitudes. In addition, the WIO is warmer than many other aquatic systems and is characterized by high salinity. The presence of PFAS and its distribution around the globe identified certain activities, like the use of fire-fighting foams in fire training at international airports as a source of contamination even in remote areas such as the Pacific Islands. In Brazil, the industrial area around São Paulo clearly showed much higher contamination with PFAS than the Amazon delta. In the WIO samples, consisting of vertical and horizontal transects, perfluorooctanoic acid (PFOA) was more abundant than perfluorosulfonic acid (PFOS) and also had higher concentrations. Overall, PFAS concentrations were much lower in the WIO samples as the majority of samples were below detection limits for PFOS and PFOA. The vast difference in the southern hemisphere marine waters is due to high PFAS concentrations found elsewhere, such as off the coast of South America, contrasting with the low concentrations in the Indian Ocean. This may be due to the South Equatorial Current that traverses thousands of kilometers of ocean with no substantial local inputs but is subject to losses of PFAS to the atmosphere and dilution due to mixing. On the east coast of Africa, only two samples were indicating continental contributions from rivers. The complex oceanic circulation of the Indian Ocean complicates the interpretation of PFAS source and fate, suggesting that patterns elsewhere in the world may not be directly applicable to the WIO.}, issn = {0048-9697} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_scherbaknikolai_2025, title = {Perfluorooctanoic acid disrupts hepatic metabolism in the developing chicken embryo}, author = {Scherbak, Nikolai and Duberg, Daniel and Kråkström, Matilda and Tikka, Pauli and Dickens, Alex M. and Engwall, Magnus and Oresic, Matej and Hyötyläinen, Tuulia}, year = {2025}, journal = {Metabolomics}, volume = {22}, number = {1}, doi = {10.1007/s11306-025-02374-5}, url = {2018089}, language = {eng}, publisher = {Springer}, keywords = {avian model; bile acids; lipids; liver metabolism; mass spectrometry; perfluorooctanoic acid}, abstract = {INTRODUCTION: Perfluorooctanoic acid (PFOA) is a widespread environmental contaminant that interferes with multiple biological pathways, with lipid metabolism being particularly vulnerable. Early-life exposure may disrupt hepatic function during development, but the underlying mechanisms are not fully understood.OBJECTIVES: This study investigated how in ovo exposure to PFOA affects hepatic metabolism in the developing chicken embryo, with a focus on identifying altered metabolic pathways and potential mediators of toxicity.METHODS: Fertilized chicken eggs (Gallus gallus domesticus) were exposed in ovo to six concentrations of PFOA (0-5 µg/g egg). Embryonic liver tissues were analysed by comprehensive metabolomic profiling using two complementary ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) platforms.RESULTS: We identified 499 metabolites, including lipids, bile acids, carboxylic acids, amino acids, and phenolic compounds. PFOA exposure caused dose-dependent disturbances in lipid, bile acid, and amino acid metabolism. Notably, multiple secondary bile acids were detected and found to be strongly affected by PFOA, suggesting a central role of bile acid modulation in mediating its effects.CONCLUSIONS: In ovo exposure to PFOA disrupts hepatic metabolism in developing chicken embryos, particularly through alterations in bile acid, lipid, and amino acid pathways. These metabolic changes may impair energy production, endocrine regulation, and organ development, with possible long-term health consequences.}, issn = {1573-3882} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_patilrajeshv_2025_1, title = {Performance Assessment of Sagacious E- Powertrain Tiller for Smart Farming}, author = {Patil, Rajesh V.}, year = {2025}, journal = {Journal of Engineering Science and Technology Review}, volume = {18}, number = {4}, pages = {148--163}, doi = {10.25103/jestr.184.20}, url = {1998213}, language = {eng}, publisher = {Technological Education Institute of Kavala}, keywords = {agriculture machine; e- powertrain tiller; power tiller rear sitting; brake system; throttle pedal assembly}, abstract = {A power tiller, as a hand tractor, is a tool used in agriculture for weeding, cultivating, and other tasks utilize by most farmers who own small farms. Numerous problems with the sitting configuration of power tillers are already present in the market. A detachable rear seating configuration that allows the farmer to sit and easily handle the tiller is one way to combat this. The design and development of the parts for this rear-seating configuration is the primary focus of the effort. It is also decided to add E-Powertrain to our tiller so that low-income farmers could afford power tillers more easily. Therefore, this work contains the computations and simulations required to complete the E-Powertrain's primary components. The brake system for the power tiller's rear seated position is designed in compliance with the requirements established by the Indian ministry of road transport and highways. SolidWorks 2018 workbench is used to model the entire system after the parameters are finalized to verify if any chassis interference. The brake and throttle pedal assembly design and analysis for the backseat seating configuration. The wheel assembly design and analysis for rear seating configuration. This involves simulating the assembly to look for interferences and ensure that it is safe to support any loads that might be applied to it. The preparation of failure mode and effects analysis and design verification plan reports necessitate prior to starting the design of the wheel assembly and brake subsystems. Finalizing the E Powertrain components through computations will allow the tiller to run constantly for a hectare of land. Moreover, packing of each chosen component is required to attain ideal weight distribution. This work successfully developed the smart E-Power tiller's rear seating configuration. The farmer sits comfortably and perform all farming tasks with detachable rear seating arrangement and depending on their needs, farmers can quickly install and disassemble this accessory.}, issn = {1791-9320} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nestordavid_2025, title = {Performance of shotgun metagenomics on whole blood from patients with suspected bloodstream infection : Challenges remain}, author = {Nestor, David and Peker, Nilay and Couto, Natacha and Hiss, Alina N. and Herbig, Alexander and Krause, Johannes and Rossen, John W. A. and Mölling, Paula and Sundqvist, Martin}, year = {2025}, journal = {Journal of Microbiological Methods}, volume = {237}, doi = {10.1016/j.mimet.2025.107231}, url = {1990526}, language = {eng}, publisher = {Elsevier}, keywords = {bacteremia; bloodstream infection; high-throughput nucleotide sequencing; metagenomics; sepsis}, abstract = {Bloodstream infections (BSI) are common, and identifying the causative organism is crucial for effective patient management. Shotgun metagenomics (SMg) has emerged as a promising diagnostic tool; however, standardized protocols are lacking. This study aimed to evaluate the use of SMg for diagnosing BSI in patients with confirmed or suspected infections, using stored samples collected at the time of blood culture (BC). DNA extraction was performed with Add-on 10 complement and SelectNA Blood Pathogen kit (Molzym) and SMg sequencing was performed on an Illumina MiSeq instrument (Illumina). The outputs from five taxonomic classification tools were compared with routine blood culture. Of the initial 51 samples (36 BCE-positive and 15 BCE-negative), 36 (71 %) were included in the taxonomic classification analysis. Fifteen samples were excluded due to a low DNA library yield (n = 8) or low sequencing output (n = 7). In two cases, SMg results matched BC findings involving one Cutibacterium acnes and one Staphylococcus aureus. These organisms could be clearly distinguished from the background level of bacterial DNA. Aside from these, SMg identified additional bacterial findings that overlapped with BC results but at low abundance making interpretation more difficult. Most SMg reads were suspected to represent contaminations, originating either from the patient or the laboratory. The output from the different taxonomic classification tools were overall similar but displayed notable differences related to their strategies for identifying bacterial findings. Based on these results, we discuss the challenges associated with SMg-based diagnosis of BSI and highlight key areas requiring further research to improve its clinical utility.}, issn = {0167-7012} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_scanderhenrik_2025, title = {Performing taste : A narrative review of the sommelier's embodied, aesthetic expertise}, author = {Scander, Henrik}, year = {2025}, journal = {International Journal of Gastronomy and Food Science}, volume = {41}, doi = {10.1016/j.ijgfs.2025.101252}, url = {1988825}, language = {eng}, publisher = {Elsevier}, keywords = {sommellerie; taste; food and beverage pairing; practice theory; sensory training}, abstract = {This narrative review explores the sommelier's role in contemporary gastronomy, focusing on how sensory training, aesthetic judgment, and interactive performance shape their expertise in high-end restaurant settings. Drawing on literature from gastronomy, cultural sociology, practice theory, and sensory science, this paper explores the sommelier's craft through three analytical lenses: embodied knowledge, aesthetic labour, and cultural mediation. I argue that sommeliers operate as cultural intermediaries who translate sensory knowledge into taste experiences through bodily practice, narrative performance, and symbolic judgment. Particular attention is given to food and wine pairing, a site where aesthetic legitimacy, cultural capital, and sensory logic intersect. The review highlights how sommelier practices are shaped by tradition and training, yet constantly renegotiated in light of sustainability concerns, technological innovation, and shifting consumer expectations. This synthesis offers new insights into the complexity of gastronomic professionalism and calls for greater interdisciplinary engagement with sommellerie as an evolving field of aesthetic, ethical, and embodied knowledge.}, issn = {1878-450X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hellbergannsofie_2025, title = {Perhaps the future has never felt as present as it does today?}, author = {Hellberg, Ann-Sofie and Hatakka, Mathias}, year = {2025}, journal = {Journal of Pedagogical Sociology and Psychology}, volume = {7}, number = {3}, pages = {1--4}, doi = {10.33902/jpsp.202514530}, url = {2028590}, language = {eng}, publisher = {Duzce University, Faculty of Education} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jakobsdttirsmriunnur_2025, title = {Perimenopausal symptoms in women with and without ADHD : A population-based cohort study}, author = {Jakobsdóttir Smári, Unnur and Valdimarsdottir, Unnur Anna and Wynchank, Dora and de Jong, Maxime and Aspelund, Thor and Hauksdottir, Arna and Thordardottir, Edda Bjork and Tomasson, Gunnar and Jakobsdottir, Johanna and Lu, Donghao and Nevriana, Alicia and Larsson, Henrik and Kooij, Sandra and Zoega, Helga}, year = {2025}, journal = {European psychiatry}, volume = {68}, number = {1}, doi = {10.1192/j.eurpsy.2025.10101}, url = {1995355}, language = {eng}, publisher = {Cambridge University Press}, keywords = {adhd; attention-deficit/hyperactivity disorder; perimenopausal symptoms; perimenopause; physical comorbidities; psychiatric comorbidities; women}, abstract = {Background: Knowledge of the impact of perimenopause on women with attention-deficit/hyperactivity disorder (ADHD) is lacking. We compared levels of perimenopausal symptoms and prevalence of severe perimenopausal symptoms among women with and without ADHD across age groups.Methods: In this cohort study, we used data from the population-based Stress-and-Gene-Analysis cohort study. ADHD diagnosis was self-reported at baseline and 5-year follow-up. At follow-up, we assessed ADHD symptoms using the Adult ADHD Self-Report Scale, perimenopausal symptoms (psychological, somatic, and urogenital) using Menopause Rating Scale (MRS), and general physical symptoms using Patient Health Questionnaire. We described mean scores and mean difference on MRS among women with and without ADHD with linear regression models and contrasted the prevalence of severe perimenopausal symptoms among women with and without ADHD, calculating prevalence ratios (PRs) with 95% confidence intervals (CIs) using modified Poisson regression models.Results: Women with ADHD (n = 535) had higher total perimenopausal symptom scores (18.0 vs. 13.0, p < 0.01) than women without ADHD (n = 4,857). The difference was most pronounced among women aged 35-39 years (19.0 vs. 12.5, p < 0.01). The prevalence of severe perimenopausal symptoms was significantly higher among women with ADHD compared to those without, both overall (54.2% vs. 30.1%, PR = 1.80, 95% CI = 1.64-1.98) and on all subdimensions (psychological: 58.6% vs. 36.0%, PR = 1.63, 95% CI = 1.51-1.76; somatic: 30.4% vs. 13.9%, PR = 2.20, 95% CI = 1.88-2.57; uro-genital: 43.2% vs. 27.5%, PR = 1.57, 95% CI = 1.40-1.77).Conclusion: Women with ADHD have higher prevalence of severe perimenopausal symptoms. These symptoms present at an earlier age than among women without ADHD, indicating an earlier onset age of perimenopause in ADHD.}, issn = {0924-9338} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lodefalkmaria_2025, title = {Persistent Hyperparathyroidism in Vitamin D-Dependent Rickets Type 2A Does Not Prevent Normalization of Hypophosphatemia or Healing of the Rickets}, author = {Lodefalk, Maria and Nilsson, Ola}, year = {2025}, journal = {Hormone Research in Paediatrics}, doi = {10.1159/000546444}, url = {1976547}, language = {eng}, publisher = {S. Karger}, keywords = {cinacalcet; hereditary vitamin d-resistant rickets; hyperparathyroidism; hypophosphatemia; vitamin d-dependent rickets type 2a}, abstract = {INTRODUCTION: Vitamin D-dependent rickets type 2A (VDDR2A) is a rare, autosomal recessive disorder caused by pathogenic variants of the VDR gene encoding the vitamin D receptor. It has been proposed to be a form of parathyroid hormone (PTH)-dependent rickets. Here, we describe in detail a girl with VDDR2A who developed a long-standing, tertiary hyperparathyroidism that did not prevent healing of the rickets nor normalization of hypophosphatemia.CASE PRESENTATION: A girl who presented with seizures at 9 months of age was diagnosed with VDDR2A. She had poor growth, alopecia, severe hypocalcemia, hypophosphatemia, elevated levels of alkaline phosphatase (ALP), PTH and 1,25-dihydroxyvitamin D, and severe rickets. Genetic studies revealed a novel homozygous microdeletion that included exon 9 of the VDR gene. She responded only partially to high oral doses of calcium, cholecalciferol, and alfacalcidol. Upon the initiation of IV calcium infusions, bone pain resolved, and the rickets healed within weeks. In parallel with decreasing ALP values, her phosphate levels normalized even though her PTH levels remained markedly elevated. PTH levels remained elevated for approximately 1 year after the normalization of S-Ca2+. Calcium infusions, despite rendering her mildly hypercalcemic, mostly failed to suppress her PTH into the normal range, consistent with tertiary hyperparathyroidism. The hyperparathyroidism eventually resolved spontaneously with continued high oral doses of calcium, cholecalciferol, and alfacalcidol, which promoted sustained normocalcemia without the need for either cinacalcet or surgery.CONCLUSION: Persistent tertiary hyperparathyroidism can develop in children with VDDR2A, but does not seem to prevent the healing of rickets nor normalization of hypophosphatemia. High doses of calcium, preferably administered intravenously, seem to be sufficient for the healing of rickets. We speculate that IV calcium compared to oral calcium increases intestinal phosphorus uptake, and once rickets has healed, improved appetite and dietary phosphorus intake together with reduced phosphorus demands due to saturated bones contribute to the normalization of phosphate levels despite persistent hyperparathyroidism.}, issn = {1663-2818} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_holmstrmingerk_2025, title = {Person-centredness of multiprofessional ward rounds in a stroke setting : Reality or chimaera?}, author = {Holmström, Inger K. and Edelbring, Samuel and Elvèn, Maria}, year = {2025}, journal = {Journal of Interprofessional Education and Practice}, volume = {40}, doi = {10.1016/j.xjep.2025.100751}, url = {2028244}, language = {eng}, publisher = {Elsevier}, keywords = {clinical decision-making; deductive content analysis; interprofessional teamwork; interviews; person-centred care; stroke; ward rounds}, issn = {2405-4526} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_24, title = {Personligt ansvar och rätten till försvar – EU-domstolens dom C-277/24 Adjak}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031774}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 27 februari 2025 kom EU-domstolens dom i mervärdesskattemålet C-277/24 Adjak. Målet avser om en företrädare som kan bli solidariskt ansvarig för ett bolags skatt har rätt att delta i en process avseende fastställande av bolagets skatt. Professor Eleonor Kristoffersson kommenterar domen.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rostamiamir_2025, title = {Perspectives on Violent Extremism : Insights from Swedish Population Registers in a Global Comparison}, author = {Rostami, Amir and Mondani, Hernan and Beckley, Amber and Sarnecki, Jerzy and Edling, Christofer}, year = {2025}, journal = {Terrorism and Political Violence}, doi = {10.1080/09546553.2025.2499168}, url = {1961613}, language = {eng}, publisher = {Routledge}, keywords = {violent extremism; sweden; far right; far left; violent islamic extremism}, abstract = {This study explores the characteristics of individuals affiliated with violent extremist milieus in Sweden, focusing on far-right, far-left, and Islamic extremist milieus. Firstly, by using a compilation of law enforcement and other Swedish population registers, we describe these milieus along a range of demographic, socioeconomic, criminal, mental health, and familial indicators. We then compare Swedish extremists to extremists globally. Our findings reveal that while demographic patterns, such as age and sex, align with international studies, significant differences emerge in areas like criminal activity, mental health prevalence, and socioeconomic factors. Compared to global data, Swedish extremists show higher levels of criminal involvement, particularly prior to radicalization, but lower prevalence of severe mental disorders. Additionally, violent Islamic extremists in Sweden exhibit a significantly higher likelihood of having extremist family members, suggesting a possible intergenerational transmission of extremist affiliation. Socioeconomic disparities are also evident, with violent far-right and violent far-left extremists displaying different educational and employment patterns compared to their international counterparts. By combining Swedish register data with international comparisons, this study highlights the importance of considering national contexts when analysing extremist profiles and emphasizes the need for comprehensive, context-based designs to prevent and counter violent extremism.}, issn = {0954-6553} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nnbylinda_2025, title = {PFAS in Swedish wastewater : Occurrence, transformation, and fate in biological treatment processes}, author = {Önnby, Linda and Liagkouridis, Ioannis and Baresel, Christian and Yeung, Leo W. Y.}, year = {2025}, journal = {Environmental Chemistry and Ecotoxicology}, volume = {7}, pages = {2744--2755}, doi = {10.1016/j.enceco.2025.10.024}, url = {2018109}, language = {eng}, publisher = {Elsevier}, keywords = {per; and polyfluoroalkyl substances; wastewater treatment plants; precursors; activated sludge; trifluoroacetic acid}, abstract = {Per- and polyfluoroalkyl substances (PFAS) are widely present and highly persistent contaminants that pose increasing challenges for wastewater treatment plants (WWTPs). This study investigates the occurrence, transformation, and fate of PFAS and their precursors in five Swedish WWTPs using activated sludge (AS) and membrane bioreactor (MBR) technologies. We applied a multi-analytical approach, including targeted PFAS, extractable organofluorine (EOF), total oxidizable precursor (TOP) assay, and suspect screening analyses to assess the fluorine mass balance and precursor transformation during treatment. Results show high detection frequencies of short-chain PFAS (e.g., PFBA, PFHxA, PFHpA) across all influent and effluent samples, while longchain compounds were rarely observed in water. No consistent removal trend was identified across treatment systems. In some cases, significant increases in effluent concentrations were observed, indicating possible transformation of both recognized and unrecognized precursors into measurable PFAS. The TOP assay results revealed distinct transformation dynamics, with more pronounced conversion in the MBR systems. Trifluoroacetic acid (TFA), analyzed separately, accounted for 90% and 93% when compared to the sum of the targeted PFAS fluorine concentrations in the influent and effluent, highlighting its dominant contribution to the overall fluorine load. EOF analysis showed that only 6.9% in influent and 4.2% in effluent could be explained by targeted PFAS, indicating a substantial unidentified organofluorine fraction. Future studies need to address and include analysis of fluorinated and pesticides as these can be potential key contributors to the unidentified fraction. The observed formation of terminal PFAS from precursors in MBR systems highlights a potential intervention point earlier in the treatment chain. Reducing precursor inputs before biological treatment may limit the generation of persistent PFAS in the effluent. Conversely, in treatment trains that include quaternary processes, the transformation to stable terminal PFAS could be advantageous, as these compounds may be more readily removed than precursors. These findings emphasize the need for broader analytical coverage and treatment strategies tailored to specific process configurations to improve PFAS management in wastewater systems.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ugarphedfeldtmalin_2025, title = {Pharmacological pain relief and women's birth experience : a systematic review}, author = {Ugarph-Edfeldt, Malin and Gustavsson, Hanne and Hildén, Karin and Cao, Yang and Backman, Helena}, year = {2025}, journal = {BMC Pregnancy and Childbirth}, volume = {25}, number = {1}, doi = {10.1186/s12884-025-07602-3}, url = {1954857}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {birth experience; childbirth satisfaction; labor; pharmacological pain relief; pregnancy}, abstract = {BACKGROUND: There is increasing interest in health care systems worldwide for maternal satisfaction with childbirth experience. The World Health Organisation (WHO) launched a recommendation 2018 regarding women's right to equal and fair intrapartum care, where the importance of pharmacological pain relief was highlighted. Our objective with this systematic review was to summarize and assess the current knowledge regarding the impact of obstetric pharmacological pain relief on maternal satisfaction with childbirth.METHODS: The databases Pub Med, Cochrane, EMBASE and CINAHL were searched for studies in the English language published after 1998 that investigated the effect of pharmacological pain relief on women´s birth experience after vaginal delivery. Studies reporting assessments of subjective satisfaction with childbirth in women planned for vaginal delivery were selected. The results were summarized narratively. For studies where comparable association measures were available, forest plots are presented. Due to heterogeneity of research questions and indirectness of measuring instruments, no meta-analyses were performed.RESULTS: A total of 15,136 women were included from 18 studies. Two randomized controlled studies, nine cohort studies, six cross-sectional studies and one case control study, all had a moderate or high risk of bias. The studies used inconsistent methods to measure outcomes; therefore, no conclusion could be drawn regarding a possible correlation between pharmacological pain relief and overall birth experience.CONCLUSIONS: This systematic review could not show a correlation between pharmacological pain relief and women´s experiences of childbirth, mainly due to large heterogeneity between studies. To evaluate pain relief during labour and improve women´s childbirth experiences, high-quality research is warranted.TRIAL REGISTRATION: The study was registered in PROSPERO (prospective register of systematic reviews) 18 Dec 2018 (ID 116744).} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kalink_2025, title = {Phenotypic factors associated with gastrointestinal side effects induced by metformin in newly diagnosed people with type 2 diabetes}, author = {Kalin, K. and Rådholm, K. and Daka, B. and Jansson, Stefan P. O. and Möllsten, A. and Tremaroli, V. and Bäckhed, F. and Rolandsson, O.}, year = {2025}, journal = {Diabetologia}, volume = {68}, number = {Suppl. 1}, pages = {S410--S411}, url = {2039848}, language = {eng}, publisher = {Springer}, abstract = {Background and aims: Metformin is one of the most common oral medications for type 2 diabetes (T2D) worldwide. Metformin treatment is associated with occurrence of gastrointestinal (GI) symptoms, which limit patient adherence to the treatment. Previously, female sex, age ≤ 65 years and BMI ≥ 25 kg/m² have been associated with GI adverse events. Furthermore, it has also been suggested that higher levels of HbA1c at baseline are associated with GI adverse events. The number of studies on the topic are limited, and thus our aim was to assess the association between phenotype and GI adverse events in people with newly diagnosed T2D.Materials and methods: The study was a prospective cohort study, called the MEtformin adverse events mediated by gut MicrobiOta (MEMO)-study. The study was performed in four Swedish regions: Västerbotten, Östergötland, Örebro, and Västra Götaland. Participants with newly diagnosed (<1 year) T2D and without medication were included and completed three visits in four months: a baseline visit (Table 1) before metformin treatment was initiated, and two visits after two and four months of metformin treatment. At each visit, data on phenotypic characteristics and metabolic biomarkers were collected. GI symptoms (diarrhoea, nausea, abdominal pain, bloating and loss of appetite) were assessed by questionnaire, and cases were defined as progression in GI symptoms compared to baseline. Statistical analysis was conducted using generalized linear regression modelling.Results: We included 168 participants, 54% were male, the mean age was 63.3 years (SD ± 9.0), and the mean BMI was 32.0 kg/m² (SD ± 5.0). Sixty-one participants (36%) developed GI side effects symptoms (cases) and 64% did not (controls) (Table 1). There was no association between age, sex, BMI and GI adverse events. Furthermore, we observed no association between baseline HbA1c, c-peptide or cholesterol and the development of GI adverse events. However, fasting plasma glucose levels measured prior to metformin treatment initiation were inversely associated with development of GI side effects (OR 0.89, p=0.041).Conclusion: Our study did not corroborate previously reported association between phenotype and gastro-intestinal adverse events of metformin in newly diagnosed people with T2D.}, issn = {0012-186X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nilssoncharlotte_2025, title = {Phosphorus speciation in sewage sludge and their ashes after incineration as a function of treatment processes}, author = {Nilsson, Charlotte and Karlsson, Stefan and Allard, Bert and von Kronhelm, Thomas}, year = {2025}, journal = {Waste Management & Research}, volume = {43}, number = {5}, pages = {378--385}, doi = {10.1177/0734242X241252913}, url = {1864088}, language = {eng}, publisher = {Sage Publications}, keywords = {sewage sludge; aluminium; apatite; incineration; phosphorus; recirculation; speciation; sustainability}, abstract = {Phosphorus (P) is a key component in agricultural fertilizers, but it is also a scarce resource, why its recycling has been thoroughly investigated and one promising resources is sewage sludge. Because of stricter regulations in terms of sludge disposal, thermal treatment (e.g. incineration) has become an attractive option. The incineration process alters the chemical speciation of P in favour to calcium-associated (apatite, apatite phosphorus (AP)) species, which is preferred for P recovery. In order to achieve qualitatively transformation, it is important to identify limiting or promoting factors. This study reports on the impact of iron, aluminium and calcium on the transformation of iron- and aluminium-phosphate (NAIP) to AP species, assessed by studying sludge and ash from 10 municipal wastewater treatment plants in Sweden. The effect of iron and aluminium added in the treatment processes was also evaluated. The obtained results show that high calcium concentration favours formation of AP species in both sludge and ashes, whereas high concentration of iron and aluminium favours formation of NAIP species in the sludge. The transformation from NAIP to AP species is hampered by aluminium, irrespectively of its origin, whereas no such correlations could be seen for iron. Therefore, in order to enable efficient P recovery from sewage sludge ash, the amount of aluminium added in the treatment process, as well as its concentration in influent streams to the treatment plants, must be limited.}, issn = {0734-242X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jonssonmarcus_2025, title = {Physical activity and health-related quality of life after lung cancer surgery- cross-sectional analyses 3 and 12 months postoperatively}, author = {Jonsson, Marcus and Hurtig-Wennlöf, Anita and Ahlsson, Anders and Westerdahl, Elisabeth}, year = {2025}, journal = {Health and Quality of Life Outcomes}, volume = {23}, number = {1}, doi = {10.1186/s12955-025-02400-z}, url = {1982862}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {health-related quality of life; lung cancer; postoperative; thoracic surgery}, abstract = {BACKGROUND: Lung cancer is one of the most frequently diagnosed cancers, and the leading cause of cancer deaths worldwide. Surgical resection is the primary curative treatment. The World Health Organization (WHO) recommends that all adults, including cancer survivors, should engage in at least 150 to 300 min of moderate-intensity aerobic physical activity per week. Positive associations have been found between self-reported physical activity and health-related quality of life (HRQoL) after lung cancer surgery. However, there is a lack of studies concerning objectively measured physical activity levels, and longer follow-ups are also missing. This study investigated the relationship between objectively measured physical activity levels and HRQoL in patients 3 and 12 months after lung cancer surgery.METHODS: Utilizing a cross-sectional design, patients were followed up 3 (n = 83) and 12 (n = 57) months after lung cancer surgery. HRQoL was assessed with the cancer-specific questionnaire EORTC QLQ-C30 and the lung-cancer-specific module LC13. Physical activity was measured with a tri-axial accelerometer (ActiGraph GT3X+).RESULTS: At 3 months after surgery, 51% (n = 42) of the patients reached the level of physical activity recommended by the WHO; the corresponding result at 12 months was 42% (n = 24). Patients who reached the recommended level of physical activity reported a better HRQoL, with better global health status and physical function as well as lower symptoms of fatigue, at both 3 and 12 months postoperatively.CONCLUSIONS: Physical activity was positively associated with HRQoL. Encouraging and supporting patients to engage in regular physical activity could contribute to better HRQoL after lung cancer surgery.TRIAL REGISTRATION: The trial was registered at ClinicalTrials.gov (NCT01961700), registration date 20,131,009.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nyberggunn_2025, title = {Physical education teachers' experiences of the meaning of feedback in PE}, author = {Nyberg, Gunn and Quennerstedt, Mikael and Tolgfors, Björn and Backman, Erik}, year = {2025}, journal = {European Physical Education Review}, doi = {10.1177/1356336X251340248}, url = {1958388}, language = {eng}, publisher = {Sage Publications}, keywords = {feedback; physical education; pete; phenomenography}, abstract = {This study explores how newly qualified physical education (PE) teachers experience the meaning of feedback through reflections on their assessment practices. We focus on the use, purpose, and content of feedback in PE practice. Assessment practices in PE have generally been used for grading purposes, often with little connection to the preceding teaching and learning. The educational quality of feedback depends on teachers' knowledge of what is supposed to be learned and how learners understand what they are supposed to know. Hence, it is important to investigate whether and how PE teacher education (PETE) prepares pre-service teachers for their professional work with feedback in PE. Individual stimulated recall interviews, a focus group interview and individual interviews with eight newly qualified teachers were conducted, and the data was analysed through a phenomenographic approach. The findings reveal that feedback is experienced in various ways, some comprising content that helps students learn what is supposed to be learned. Other ways of experiencing feedback generate content that does not relate to any intended learning goal other than being physically active in the here and now. The findings are discussed in relation to Hattie and Timperley's (2007) model of feedback as well as in relation to PETE and the significance of providing possibilities for future teachers to learn about the ways in which feedback can be educationally worthwhile.}, issn = {1356-336X}, file = {https://oru.diva-portal.org/smash/get/diva2:1958388/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_axelssonsvedelllena_2025, title = {Physical exercise as add-on treatment in adults with ADHD - the START study : a randomized controlled trial}, author = {Axelsson Svedell, Lena and Lindvall, Mialinn Arvidsson and Lidström-Holmqvist, Kajsa and Cao, Yang and Msghina, Mussie}, year = {2025}, journal = {Frontiers in Psychiatry}, volume = {16}, doi = {10.3389/fpsyt.2025.1690216}, url = {2014519}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {insomnia; intervention; non-pharmacological; quality of life}, abstract = {Adult ADHD is associated with various health challenges and reduced quality of life. Current guidelines recommend multimodal treatment, and physical exercise has emerged as a promising non-pharmacological alternative, although evidence from randomized controlled trials remains limited. In this randomized controlled trial, we aimed to assess the clinical effectiveness of physical exercise as an add-on treatment for adults with ADHD compared to treatment as usual. The trial included adults with a clinically confirmed diagnosis of ADHD was conducted at one Psychiatric clinic in Sweden. Participants were randomly assigned (2:1, no stratification) using an electronic case-report platform, to either physical exercise (the protocolized 12-week intervention START) or treatment as usual (local community care). Primary outcome was the ASRS-v1.1 Symptom checklist at 12 weeks after inclusion. The analysis followed a modified intention-to-treat principle, excluding participants who provided no data beyond baseline. Of the 63 participants enrolled, 43 were randomly assigned to START physical exercise intervention and 20 to treatment as usual. After accounting for withdrawals (n = 11) and loss to follow up (n = 11), the primary analysis included data from 41 participants (30 assigned to START intervention and 11 to treatment as usual). The START intervention resulted in improved ADHD symptoms after 12 weeks, as measured by ASRS-v1.1. Symptom improvement differed significantly between groups (mean difference -6.98, 95% CI: -12.30 to -1.65; p = 0.012) with an effect size of 0.93 favoring the intervention group. No serious adverse events were reported. The results suggest that physical exercise may be a feasible, safe and clinically meaningful complement to standard care for adults with ADHD. However, the findings should be interpreted in the light of potential confounders and methodological limitations. This trial is registered with the ClinicalTrials.gov. Date of registration: 2021-05-14.CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT05049239, identifier NCT05049239.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wiedemannthomas_2025, title = {Physics-informed robotic airflow exploration and mapping with a swarm of mobile robots}, author = {Wiedemann, Thomas and Scheffler, Martina and Shutin, Dmitriy and Lilienthal, Achim J.}, year = {2025}, journal = {The international journal of robotics research}, volume = {44}, number = {13}, pages = {2105--2125}, doi = {10.1177/02783649251329421}, url = {1956522}, language = {eng}, publisher = {Sage Publications}, keywords = {robotic exploration; airflow mapping; navier-stokes equations; multi-robot system; uncertainty-driven exploration; physics-informed robotics}, abstract = {Airflow is the key transport mechanism for airborne substances like gas or particulate matter. It is of great interest in many applications ranging from evacuation planning to analyzing indoor ventilation systems. However, accurately determining a spatial map of the airflow is difficult and time-consuming since environmental parameters and boundary conditions are often unknown. This work introduces a novel adaptive sampling strategy for mobile robots. The strategy allows multiple mobile robots with anemometers to autonomously collect airflow measurements and generate a two-dimensional spatial map of the airflow field. Using a Domain-knowledge Assisted Exploration approach, the robots respond in real-time to the measurements already taken and determine the most informative locations online for further measurements. We incorporate the Navier-Stokes Partial Differential Equations to fuse the collected data with model assumptions. By casting the airflow model into a probabilistic framework, we can quantify uncertainties in the airflow field and develop an intelligent, uncertainty-driven exploration strategy inspired by optimal experimental design principles. This strategy combines an estimated uncertainty map with a rapidly exploring random tree path planner. Additionally, using the Navier-Stokes equations allows us to interpolate spatially between measurements in a physics-informed way, enabling us to construct a more accurate airflow map. We implemented and evaluated the proposed concept in simulations and experiments in a laboratory environment, where five mobile robots explore artificially generated airflow fields. The results indicate that our approach can correctly estimate the airflow and show that the proposed adaptive exploration strategy gathers information more efficiently than a predefined sampling pattern.}, issn = {0278-3649} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_iglesiasxavier_2025, title = {Physiological responses to full and segmented duet routines in elite artistic swimmers}, author = {Iglesias, Xavier and Rodriguez-Zamora, Lara and Carrasco-Marginet, Marta and Irurtia, Alfredo and Rodríguez, Ferran A. and Fernández-Jarillo, Ignacio and Chaverri, Diego}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {10}, doi = {10.1371/journal.pone.0333791}, url = {2004921}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {Artistic swimming combines prolonged breath-hold periods with high-intensity movements, resulting in unique physiological demands. Direct measurement of key variables such as oxygen uptake (VO₂) during routines is limited by frequent immersion. However, VO₂ monitoring is essential for understanding the balance between aerobic and anaerobic energy contributions, guiding training strategies and reducing injury risk. This study aimed to analyze the acute physiological responses, VO₂, blood lactate concentration, and heart rate, during free duet routines in elite artistic swimmers, using a segmented protocol that emphasized the two longest apneas. Sixteen elite artistic swimmers performed both complete and segmented versions of the routine. VO₂ was estimated using retro-extrapolation, while lactate was measured after each phase, and heart rate was continuously monitored. The protocol included six measurement points: pre-routine, pre- and post-apnea 1 and 2, and post-routine. VO₂ increased rapidly, reaching nearly 90% of VO₂ peak within 67 seconds (mean: 61.8 ± 15.1 mL·min ⁻ ¹·kg ⁻ ¹). Blood lactate concentration rose progressively, peaking at 5.93 ± 1.41 mmol·L ⁻ ¹. Heart rate exhibited large fluctuations, with a maximum of 203.8 ± 5.0 beats·min ⁻ ¹ and a minimum of 71.9 ± 16.6 beats·min ⁻ ¹, reflecting a bradycardic response during apneas. No significant changes were observed in VO₂ or lactate between pre- and post-apnea values, as measured around the two longest apneas within the routine. These findings suggest that, under the specific conditions of this study, short-duration apneas (< 20 s) may be insufficient on their own to elicit distinct physiological shifts. However, the progressive increases observed in blood lactate and heart rate throughout the full routine suggest that the overall physiological load may be influenced more by sustained exercise intensity and the cumulative effect of repeated apneas than by isolated breath-hold events.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_adamikmark_2025, title = {PlanOwl : Automated PDDL Files Generation from OWLOntologies and Visual Language Models}, author = {Adamik, Mark and Forte, Paolo}, year = {2025}, volume = {7:1}, pages = {634--643}, doi = {10.1609/aaaiss.v7i1.36944}, url = {2028657}, language = {eng}, publisher = {AAAI Press}, abstract = {Automated task planning traditionally relies on manually generated domain models, creating bottlenecks in scalability and requiring extensive domain expertise. This paper presents a novel framework to automate the process of generating Planning Domain Definition Language (PDDL) domains and problem files by integrating Web Ontology Language (OWL) ontologies with Visual Language Models (VLMs). Our approach leverages the rich semantic structure of OWL ontologies to systematically define domain classes, predicates, and actions, while VLMs ground abstract ontological concepts in concrete visual observations—automating the generation of instance‑specific planning problems. The proposed framework transforms ontological knowledge into PDDL domain files through a mapping algorithm that preserves semantic relationships and logical constraints. The VLM performs visual scene analysis to identify relevant objects, attributes, and spatial configurations for generating initial states, while natural language instructions are used to derive goal states.We evaluate the framework across multiple planning domains, demonstrating that it generates syntactically correct and semantically coherent PDDL domain and problem files directly from OWL ontologies, camera images, and natural language inputs. The resulting files are comparable in quality to those manually generated by planning experts and outperform previous automated systems in terms of semantic fidelity and adaptability.}, file = {https://oru.diva-portal.org/smash/get/diva2:2028657/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sjlinkarl_2025, title = {Plasma Profiles of Neuroglial Injury Biomarkers after Ischemic Stroke}, author = {Sjölin, Karl and Björn, Röyter and Forgo, Bianka and Aulin, Julia and Kultima, Kim and Lindbäck, Johan and Ström, Jakob O. and Burman, Joachim}, year = {2025}, journal = {Translational Stroke Research}, volume = {16}, number = {6}, pages = {2185--2194}, doi = {10.1007/s12975-025-01380-y}, url = {1995349}, language = {eng}, publisher = {Springer}, keywords = {glial fibrillary acidic protein; neurofilament; stroke; tau; ubiquitin carboxy-terminal hydrolase l1}, abstract = {OBJECTIVE: To determine the temporal profiles of glial fibrillary acidic protein (GFAP), neurofilament light (NFL), total tau (t-tau), and ubiquitin carboxy-terminal hydrolase L1 (UCHL1) in plasma the first week after acute ischemic stroke, and identify the optimal time points for assessing infarct volume by these biomarkers.PATIENTS & METHODS: In this cohort study, biomarker plasma concentrations were determined daily over the first week and at 90 days after symptom onset in patients with acute ischemic stroke. A brain MRI was performed on day three. Temporal variations in biomarker levels were analyzed using linear mixed-effects models, and optimal time points for infarct volume correlation were identified with continuous Pearson analysis.RESULTS: 38 patients with a median age of 78 (IQR 72-86) and mean infarct volume of 5.5 (IQR 1.6-17) cm3 were included. We identified three distinct temporal patterns: (1) a parabolic trajectory of GFAP, reaching zenith after three days, (2) a consistent increase in NFL throughout the week, and (3) an initial surge in t-tau and UCHL1 levels, stabilizing by day three. The optimal time point for infarct volume correlation occurred at 119 h for GFAP (r = 0.94, 95% CI: [0.84-0.98]), 144 h for NFL (r = 0.78, [0.47, 0.92]), 122 h for t-tau (r = 0.82, [0.56, 0.93]) and 113 h for UCHL1 (r = 0.83, [0.60, 0.93]).INTERPRETATION: This high-resolution serial sampling of plasma GFAP, NFL, t-tau, and UCHL1 the first week after acute ischemic stroke identified three distinct temporal profiles. These biomarkers provided the most accurate infarct volume assessment 4-6 days after symptom onset.CLINICALTRIALS: gov NCT03812666 (registration date 2019-01-23).}, issn = {1868-4483} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_chamounsanharib_2025, title = {Plasma troponin T reflects lower motor neuron involvement on electromyography in amyotrophic lateral sclerosis}, author = {Chamoun, Sanharib and Imrell, Sofia and Upate, Zane and Kläppe, Ulf and Öijerstedt, Linn and Yazdani, Solmaz and Andersson Franko, Mikael and Foucher, Juliette and Azizi, Louisa and Lovik, Anikó and Samuelsson, Kristin and Press, Rayomand and Fang, Fang and Svennberg, Emma and Juto, Alexander and Ingre, Caroline}, year = {2025}, journal = {Brain Communications}, volume = {7}, number = {3}, doi = {10.1093/braincomms/fcaf177}, url = {1959269}, language = {eng}, publisher = {Oxford University Press}, keywords = {amyotrophic lateral sclerosis; biomarkers; electromyography; motor neuron disease; troponin t}, abstract = {Cardiac troponin T (cTnT) is elevated in neuromuscular conditions without apparent cardiac disease, including Amyotrophic Lateral Sclerosis (ALS). The reason for this increase is unclear. Since cTnT is found in both cardiomyocytes and skeletal muscle cells, we aimed to investigate the latter as a possible cTnT source. We examined the correlation of cTnT in venous blood to lower motor neuron (LMN) involvement on Electromyography (EMG). A positive correlation between EMG findings and cTnT levels would indicate that cTnT is a biomarker for LMN involvement in ALS. This observational cohort study was conducted on a tertiary referral centre for neuromuscular diseases in Stockholm, Sweden. Consecutive patients with ALS were included. EMG was performed during diagnostic work-up, and high-sensitive cardiac troponin T (hs-cTnT), plasma creatine kinase (CK), and serum neurofilament light (NfL) were analysed within 6 months of the EMG. King's stage and score on the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) closest to hs-cTnT sampling were noted. In total, 50 ALS patients diagnosed between 1 January 2014 and 31 December 2018 were included and followed until death, invasive ventilation, or the 14 August 2024. Hs-cTnT correlated positively with the number of muscular regions involved (τ = 0.283, P = 0.009) and percentage of muscles involved on EMG (ρ = 0.367, P = 0.009). Hs-cTnT was associated with the percentage of muscles involved in EMG in the adjusted linear regression. Patients with higher hs-cTnT had more advanced King's stage, both when numerical hs-cTnT and subgrouping high (≥15 nanogram/L) versus normal hs-cTnT was used (τ = 0.253, P = 0.021 and U = 197.5, P = 0.022, respectively). Hs-cTnT was neither correlated to ALSFRS-R total score (ρ = -0.176, P = 0.220 and U = 249.5, P = 0.233, respectively) nor ALSFRS-R excluding respiratory domain score (ρ = -0.069, P = 0.632 and U = 280.5, P = 0.558, respectively). High versus normal hs-cTnT did not predict survival (univariate analysis, HR = 1.824, P = 0.060). Numerical hs-cTnT was associated with shorter survival (univariate analysis, HR = 1.635, P = 0.017) but not after adjusting for age at diagnosis (HR = 1.413, P = 0.105). This study illustrates that ALS patients with higher hs-cTnT have more spread disease as evidenced by the positive correlation between hs-cTnT and both EMG and King's stage. This is not true for established biomarkers of muscle damage (CK) and neuroaxonal damage (NfL). These findings need to be confirmed in larger studies but suggest that hs-cTnT is a biomarker of LMN involvement in patients with ALS and could be used in clinical trials.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kerezoudievangelian_2025_3, title = {Pleurotus eryngii Mushrooms Fermented with Human Fecal Microbiota Protect Intestinal Barrier Integrity : Immune Modulation and Signalling Pathways Counter Deoxycholic Acid-Induced Disruption in Healthy Colonic Tissue}, author = {Kerezoudi, Evangelia N. and Zervakis, Georgios I. and Pletsa, Vasiliki and Kyriacou, Adamantini and Brummer, Robert Jan and Rangel, Ignacio}, year = {2025}, journal = {Nutrients}, volume = {17}, number = {4}, doi = {10.3390/nu17040694}, url = {1940877}, language = {eng}, publisher = {MDPI}, keywords = {pleurotus eryngii mushrooms; ussing chamber; cytokines; deoxycholic bile acid; gut barrier; signalling pathway}, abstract = {Background: This study explores the potential of the Pleurotus eryngii mushroom fermentation supernatant (FS-PEWS) as an intervention for mitigating sodium deoxycholate (SDC)-induced intestinal barrier dysfunction and inflammation.Methods: FS-PEWS was assessed for its protective effects against SDC-induced barrier dysfunction and inflammation using an in vitro Caco-2 cell model and ex vivo colonic biopsies from healthy adult donors, where barrier integrity, permeability, immunomodulation and receptor-mediated pathways were evaluated.Results: In Caco-2 cells, SDC exposure downregulated ZO-1, occludin, and claudin-1 expression, with FS-PEWS restoring ZO-1 and claudin-1 levels while maintaining cell viability. In colonic biopsies from healthy adults, FS-PEWS maintained tissue integrity and selectively mitigated transcellular permeability without affecting paracellular permeability when combined with the stressor. Additionally, FS-PEWS exhibited potent anti-inflammatory effects, reducing pro-inflammatory cytokines, e.g., TNF-α, IL-6, and IL-1β and modulating receptor-mediated pathways, i.e., TLR-4, dectin-1.Conclusions: These results demonstrate the potential of FS-PEWS to sustain intestinal barrier function and modulate immune responses under stress, highlighting its therapeutic potential for managing gut barrier dysfunction and inflammation associated with microbial metabolite-induced disruptions.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_peterssonjoakim_2025_1, title = {Police and Social Services’ Response To Intimate Partner Violence in Rural and Remote Areas in Sweden}, author = {Petersson, Joakim and Larsson, Anna-Karin L. and Strand, Susanne J. M.}, year = {2025}, journal = {Journal of family Violence}, doi = {10.1007/s10896-025-00855-8}, url = {1944630}, language = {eng}, publisher = {Springer}, keywords = {intimate partner violence; police; risk management; collaboration}, abstract = {Purpose: This study aimed to explore the perceptions and experiences of social workers and police officers in terms of risk management and inter- and intra-agency collaboration in cases of intimate partner violence (IPV) in rural and remote areas in Sweden.Method: Adopting an exploratory qualitative research design, 13 semi-structured focus group interviews with 38 social workers and six police officers from six rural and remote regions were conducted. Data were analyzed using thematic analyses.Results: In relation to our informants’ work with risk management responses, two themes were identified related to barriers and possibilities. In terms of collaboration, two themes were identified in the data: barriers to inter- and intra-agency collaboration, and facilitators of inter- and intra-agency collaboration. Overall, the results of this study correspond to previous research. However, novel findings related to possibilities with risk management responses and collaboration specific to a rural and remote context.Conclusions: The results of this study are discussed in terms of policy and practical implications for social workers and police officers in general and in relation to the unique context of rural and remote areas. As such, there is an incongruence between current urban-centric policies of IPV prevention and the specific structural and cultural characteristics of sparsely populated areas.}, issn = {0885-7482}, file = {https://oru.diva-portal.org/smash/get/diva2:1944630/FULLTEXT01.pdf} } @book{ca0f099bbf2a435cee8f97bef5e8cbaa_olssonjan_2025_1, title = {Policy i teori och praktik}, author = {Olsson, Jan and Berg, Monika and Hysing, Erik and Kristianssen, Ann-Catrin and Petersén, Anna}, year = {2025}, url = {1988715}, language = {swe}, publisher = {Studentlitteratur AB} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tysklindemman_2025, title = {Politicised or Political : On Agonism and School as ‘Free Time’}, author = {Tysklind, Emma N. and Tryggvason, Ásgeir}, year = {2025}, journal = {Studies in Philosophy and Education}, volume = {44}, pages = {305--316}, doi = {10.1007/s11217-024-09977-w}, url = {1927947}, language = {eng}, publisher = {Springer}, keywords = {agonism; school; democratic education; mouffe; masschelein & simons}, abstract = {At the centre of this paper is the distinction between a politicised school, and school as a political space. We take note of Papastephanou’s (2005) warning not to make education the passive receiver of political thought. Based on Masschelein and Simons (2013), we criticise the tendency to conceptualise democratic education, particularly agonistic democratic education, as the implementation of political theory in a school context. We draw on their idea of school as free time, to argue that democratic education should envision the classroom as political in itself, that is, as a place for negotiation and renewal, where the ends are not predetermined. When school becomes a place to implement political theory, when it is politicised, then it is stripped of its own political potency. In scholastic terms, it is tamed. In this paper, a fusion of Mouffean agonism with Masschelein and Simons’ conception of school, works to form an understanding of agonistic democratic education as a time and place for the formation of community and for the negotiation of identity, under protection from the non-accountability (Arendt 1961) that characterises scholastic practice.}, issn = {0039-3746}, file = {https://oru.diva-portal.org/smash/get/diva2:1927947/FULLTEXT01.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_anckarcarsten_2025_1, title = {Politiska system : Former, trender och utmaningar}, author = {Anckar, Carsten and Denk, Thomas}, year = {2025}, pages = {453--466}, url = {2031943}, language = {swe}, publisher = {Studentlitteratur AB} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wistrandsten_2025_3, title = {Polyfem som problem : Komposition och tematik i Willy Kyrklunds Polyfem förvandlad}, author = {Wistrand, Sten}, year = {2025}, journal = {HYBRID: Mellan Akademi, Kyrka & Samhälle}, number = {3}, pages = {95--125}, doi = {10.58412/hyb.v3i4.40366}, url = {2010214}, language = {swe}, publisher = {Akademi för Ledarskap och Teologi}, keywords = {composite novel; willy kyrklund; polyfem förvandlad; kompositroman}, abstract = { När Willy Kyrklunds Polyfem förvandlad kom ut 1964 förbryllades recensenterna över underrubriken ”roman”, som utmanade deras förväntningar på en text av det slaget. Genreangivelsen har sedan diskuterats av alla som skrivit utförligare om boken. Det rör sig onekligen om en brokig och mångstämmig textsamling, femton fristående avsnitt som varken hålls ihop av ett genomgående narrativ eller av en gemensam värld. Däremot är det lätt att notera en rad olika mer eller mindre frekvent återkommande motiv som går in i varandra och bildar skiftande mönster. Artikeln utgår från begreppen familjelikhet och kompositroman, för att beskriva hur texten är gjord och fungerar och vilka konsekvenserna blir när man försöker tolka den. Slutsatsen blir att Polyfem förvandlad ansluter till Kyrklunds fortlöpande, passionerade men dåraktiga och fåfänga, protest mot människans villkor och att det är just i den protesten som det djupast mänskliga alltid finns.}, issn = {2004-5425} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisioannis_2025_10, title = {Poor health-related quality of life despite Lupus Low Disease Activity State or Definitions of Remission in systemic lupus erythematosus (SLE) remission in patients with SLE : results from a clinical trial setting}, author = {Parodis, Ioannis and Lindblom, Julius and Palazzo, Leonardo and Tsoi, Alexander and Cetrez, Nursen and Ala, Henri and Nikpour, Mandana and Levitsky, Adrian and Strand, Vibeke}, year = {2025}, journal = {RMD Open}, volume = {11}, number = {4}, doi = {10.1136/rmdopen-2025-006061}, url = {2010709}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {fatigue; health-related quality of life; pain; systemic lupus erythematosus}, abstract = {OBJECTIVE: To determine the prevalence of poor health-related quality of life (HRQoL) in patients with systemic lupus erythematosus (SLE) in Lupus Low Disease Activity State (LLDAS) or Definitions of Remission in SLE (DORIS) remission and sustained LLDAS or sustained DORIS remission, after a 52-week therapeutic intervention.METHODS: We analysed data from four phase III trials of belimumab in SLE (BLISS-52, BLISS-76, BLISS-SC, EMBRACE; n=2406). Sustained LLDAS/remission was defined as persistent LLDAS/remission for at least two visits, maintained through week 52. Poor HRQoL was defined as Short Form-36 (SF-36) physical/mental component summary (PCS/MCS) and domain scores ≤the normative fifth percentile, Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F) scores <30 and responses of 'some/moderate problems' or 'extreme/major problems' in any of the five dimensions of the three-level version of EuroQol 5-Dimension (EQ-5D) health questionnaire.RESULTS: At week 52, among patients in LLDAS, remission, sustained LLDAS and sustained remission, 15.7%, 13.6%, 14.3% and 9.0% reported poor SF-36 PCS, and 12.5%, 11.4%, 12.9% and 14.0% reported poor SF-36 MCS scores, respectively. The highest frequencies were reported in the physical functioning domain (24.0%-26.3%), while 18.5%-26.2% reported FACIT-F scores 30. Among EQ-5D dimensions, pain/discomfort yielded the greatest frequencies of poor HRQoL experience (27.9%-28.7%). While significant improvements were observed among patients achieving the treatment goals in all HRQoL outcomes over the 52-week study period, PCS scores remained below population norms.CONCLUSIONS: Despite LLDAS or DORIS remission, notable proportions of SLE patients report poor HRQoL, indicating that current therapeutic goal definitions do not fully capture patients' perspectives of health.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_laegreidolemartin_2025, title = {Popular Support for Climate Policies Across Political Divides? The Importance of Climate Concern}, author = {Laegreid, Ole Martin and Klemetsen, Marit and Aasen, Marianne}, year = {2025}, journal = {Scandinavian Political Studies}, volume = {48}, number = {2}, doi = {10.1111/1467-9477.70001}, url = {1951163}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {climate change concern; climate policy; political orientation; public opinion; supply-side and demand-side policy}, abstract = {Lack of broad public support for climate policies is a major barrier to transitioning to a low-carbon economy. Multiple studies report higher support for emission-reducing policies among left-leaning and climate-concerned individuals, but the literature is mute about the interaction effects between the two factors. Do left-leaning individuals with low climate concern support climate policies, and what about right-leaning individuals with high concern? The answers to these questions will have important implications for political mobilization for climate policies: Increasing concerns for climate change, for instance by highlighting the consequences of climate change, might be a forceful strategy for some audiences but not for others. We examine the potential interaction between climate concern and a composite measure of political value orientation with statistical analyses of Norwegian survey data for the period 2018-2020. As outcome variables, we examine support for both demand- and supply-side policy - fossil fuel pricing and reduced oil production - to provide more general results. Our study indicates a positive relationship between climate concern and policy support across the full political spectrum. Right-leaning political value orientation moderates but does not deter the relationship between climate concern and support for climate policies. These findings hold for both fossil fuel pricing and reduction in oil production.}, issn = {0080-6757} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_linnanencecilia_2025, title = {Possibilities and Limitations in Person-Centred Cancer Care : A Qualitative Study}, author = {Linnanen, Cecilia and Hemberg, Jessica and Bjerga, Grethe H. and Ueland, Venke and Bergdahl, Elisabeth}, year = {2025}, journal = {Scandinavian Journal of Caring Sciences}, volume = {39}, number = {1}, doi = {10.1111/scs.70002}, url = {1942777}, language = {eng}, publisher = {Blackwell Publishing}, keywords = {cancer care; caring science; failure demand; health care management; health care professionals; person‐centred care}, abstract = {BACKGROUND: For cancer care to be high-quality, a shift is needed from a healthcare system that is designed around disease and institutions to one devised with a holistic perspective on human beings.AIM: To gain a deeper understanding of healthcare professionals' experiences of the possibilities and limitations for providing person-centred care to alleviate suffering among patients within cancer care.METHOD AND MATERIAL: A qualitative and explorative design was used. The data material consisted of texts from four focus group interviews with 15 nurses and physicians from a cancer clinic in Finland during January and February 2024. A qualitative content analysis was applied as a method. The COREQ checklist was used.FINDINGS: Continuity, multidisciplinary collaboration, supporting collegial relationships, work ethics, and competence were seen as factors promoting person-centred care. The organisation's various boundaries, failure demand, and emotional limitations were seen as factors that limited person-centred care. DISCUSSION: The organisational management and healthcare professionals' ability to collaborate with the patient can promote opportunities and limit barriers in the unpredictable reality of cancer care and so lead to increased person-centred care.CONCLUSIONS: Healthcare professionals' internal abilities are comprehensive. If the healthcare organisation were more integrated through better collaboration and flexibility between different instances, cancer care could alleviate patient suffering and simultaneously reduce failure demand.RELEVANCE TO CLINICAL PRACTICE: Factors such as failure demand slow down care work, and by gaining a deeper understanding of the problems, leaders, together with healthcare professionals in healthcare organisations, can find solutions to address the problems and save time and resources for the benefit of both patients and healthcare professionals.}, issn = {0283-9318} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_brauerjohn_2025_1, title = {Possibilities and limitations in the planning and provision of local ALMPs in rural settings – perspectives from municipalities in northern Sweden}, author = {Brauer, John}, year = {2025}, journal = {Planning Practice & Research}, pages = {1--17}, doi = {10.1080/02697459.2025.2574635}, url = {2007626}, language = {eng}, publisher = {Routledge}, keywords = {active labour market programmes; rural areas; local development; local government}, abstract = {Many welfare states in the Global North have decentralised active labour market programmes (ALMPs) from national to sub-national level. But how have these decentralisation processes, taking place against the backdrop of an urban bias, affected rural municipalities? The paper aims to improve the understanding of possibilities and limitations that arise in the planning and provision of ALMPs by local governments in rural settings, by exploring and analysing rural municipalities in northern Sweden. Through interviews with municipal ALMP planners, the paper illustrates challenges related to low economies of scale, the pace of national reforms, and support for groups with low employability.}, issn = {0269-7459}, file = {https://oru.diva-portal.org/smash/get/diva2:2007626/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_grafstrmtove_2025, title = {Post COVID-19 condition phenotypes : A prospective cohort study identifying four symptom clusters and their impact on long-term outcomes}, author = {Grafström, Tove and Barros, Guilherme W. F. and Persson, Ida-Lisa and Sundh, Josefin and Forsell, Mattias N. E. and Ahlm, Clas and Månsson, Emeli and Tevell, Staffan and Lind, Alicia and Normark, Johan and Cajander, Sara}, year = {2025}, journal = {Journal of Infection and Public Health}, volume = {18}, number = {12}, doi = {10.1016/j.jiph.2025.102994}, url = {2006607}, language = {eng}, publisher = {Elsevier}, keywords = {covid-19; clusters; hrqol; long-covid; post covid-19 condition; symptoms}, abstract = {BACKGROUND: Current evidence indicates that Post COVID-19 Condition (PCC) is multifaceted with distinct phenotypes. While previous studies have identified symptom clusters-commonly featuring fatigue, respiratory symptoms, and cognitive impairment-findings have been inconsistent, and no clear consensus exists. Moreover, how these symptom clusters evolve over time, particularly beyond the first year post-infection, remains poorly understood.METHODS: This multicentre prospective cohort study included 470 hospitalised and non-hospitalised adult individuals from the CoVUm study across four sites in Sweden between 2020 and 2021. Follow-ups were conducted up to 3 years after infection to assess persistent symptoms, health-related quality of life (HRQoL), and work capacity. Symptom clusters at 6 months were identified via hierarchical cluster analysis, and participants were tracked using a k-nearest neighbour algorithm.RESULTS: The most common symptoms at 6 months were fatigue (33 %), dyspnoea (32 %), mental fatigue (30 %), and concentration difficulties (28 %), with a median EQ-5D-5L index of 0.98 (IQR 0.93-1). Four distinct symptom clusters were identified: (i) "Few Symptoms" (n = 265, 57 %), (ii) "Respiratory Symptoms" (n = 66, 14 %), (iii) "Neurocognitive Symptoms" (n = 75, 16 %), and (iv) "Multisystem Symptoms" (n = 52, 11 %). Participants in the latter three clusters were older, had more comorbidities, and were more often hospitalised during primary COVID-19 infection. These clusters also had significantly lower HRQoL compared to the "Few Symptoms" cluster. Over time, more than half of participants transitioned to a cluster with fewer or no symptoms, with significant perceived HRQoL improvement in the "Multisystem Symptoms" cluster.CONCLUSION: While many patients with PCC improved over time, a subset had persistent symptoms at 3 years, especially if primary infection required hospitalisation. The identification of symptom clusters and their trajectories over time contributes to a better understanding of PCC heterogeneity, ultimately bringing the field closer to consensus on the classification and long-term impact of PCC.}, issn = {1876-0341} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_elhajjvictorgabriel_2025_4, title = {Posterior fossa decompression in syndromic children with chiari-like posterior fossa crowding : a nationwide US-based study}, author = {El-Hajj, Victor Gabriel and Mwambali, Josué Aganze and Al-Rikabi, Ihab Ahmad and Öhlen, Erik and Gharios, Maria and Staartjes, Victor E. and Roy, Joanna M. and Musmar, Basel and Jabbour, Pascal and Edström, Erik and Elmi-Terander, Adrian}, year = {2025}, journal = {Child's Nervous System}, volume = {41}, number = {1}, doi = {10.1007/s00381-025-06954-7}, url = {2013559}, language = {eng}, publisher = {Springer}, keywords = {chiari malformation; pediatric; posterior fossa; syndromic}, abstract = {INTRODUCTION: Posterior fossa crowding, due to cerebellar tonsil herniation, often requires surgery with posterior fossa decompression (PFD). Although most cases are due to a Chiari-1 malformation (CM1), some are due to concomitant congenital conditions, mimicking a radiological CM1. The aim of this study was to compare PFD outcomes between CM1 and the syndromic Chiari-like crowding of the posterior fossa. A national pediatric surgical database was used to compare baseline characteristics and short-term postoperative outcomes.METHODS: Pediatric patients undergoing PFD (2012-2021) were identified in the ACS NSQIP-P database. Baseline characteristics and 30-day outcomes were compared between syndromic and non-syndromic cases. Multivariate logistic regression identified factors associated with readmission and reoperation.RESULTS: Among 6,910 patients who underwent PFD, 752 (11%) had associated syndromes or conditions. The most common syndromes were chondrodystrophies (28%), fetal alcohol syndrome (14%), and Klippel-Feil syndrome (10%). Syndromic patients were younger, had lower BMI, and exhibited a significantly higher prevalence of comorbidities, including pulmonary, gastrointestinal, cardiac, and neurological conditions (all p < 0.001). They also experienced longer hospital stays (mean 5.17 vs. 3.64 days; p = 0.010), higher rates of 30-day complications (12% vs. 8.7%; p = 0.003), readmissions (9.4% vs. 7.1%; p = 0.021), and reoperations (6.6% vs. 2.9%; p < 0.001). In adjusted analysis, syndromic cases were not independently associated with increased 30-day complications or readmissions but remained significantly associated with 30-day reoperation (OR 1.51; 95% CI 1.03-2.19; p = 0.032).CONCLUSION: The syndromic Chiari-like condition is associated with distinct baseline characteristics and higher short-term complication rates following PFD compared to true CM1. While syndromic status was independently associated with reoperation, it was not an independent predictor of overall complications or readmissions. These findings suggest that patients with syndromes mimicking CM1 represent a clinically and etiologically distinct entity, warranting tailored management and further investigation.}, issn = {0256-7040} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_almfredrik_2025, title = {Postoperative Analgesic Regimens and Their Satisfaction Rates-Data from the Swedish Quality Register for Tonsil Surgery}, author = {Alm, Fredrik and Odhagen, Erik and Sunnergren, Ola and Nerfeldt, Pia}, year = {2025}, journal = {The Laryngoscope}, volume = {135}, number = {1}, pages = {140--147}, doi = {10.1002/lary.31691}, url = {1889800}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {pain management; patient satisfaction; tonsillectomy}, abstract = {OBJECTIVE: To describe postoperative analgesic regimens and patient-reported pain-related outcomes after tonsil surgery.METHODS: Cohort study including perioperative data (n = 9274) and patient-reported outcome measures (n = 5080) registered in the Swedish Quality Register for Tonsil Surgery during 2023.RESULTS: After tonsil surgery, 92.7% received at least paracetamol and a NSAID/COX inhibitor, while 6.8% received no NSAID/COX inhibitor. Opioids were prescribed after tonsillectomy to 62.9% of adults and less often to adolescents and children (13-17-year-olds: 48.2%, 6-12-year-olds: 8.8%, 0-5-year-olds: 4.0%). Clonidine was frequently prescribed to 0-5-year-olds after tonsillectomy (54.4%). Overall, 11.7% reported dissatisfaction with the pain treatment, with the highest dissatisfaction rate after tonsillectomy in adolescents (20.6%) and adults (20.0%), and the lowest after tonsillotomy in children (4.9-6.8%). The most common complaint among dissatisfied patients was analgesics not being sufficiently helpful. Adult patients who received addition of opioids were less dissatisfied with the pain treatment (15.9% vs. 25.9%, p < 0.001), but also reported more side effects (5.7% vs. 2.7%, p = 0.039), compared with patients who received only paracetamol and NSAID/COX inhibitors.CONCLUSION: Tonsil surgery patients in Sweden receive various analgesic regimens. Although most are satisfied with pain treatment, there is room for improvement, particularly among adolescents and adults undergoing tonsillectomy. Paracetamol and a NSAID/COX inhibitor seem advisable as basic treatment. However, many patients need more effective treatment. The addition of opioids in adults results in greater satisfaction with pain treatment, but safety issues with opioid prescriptions must be taken into consideration.LEVELS OF EVIDENCE: Level 4 Laryngoscope, 2024.}, issn = {0023-852X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_engesteringvild_2025, title = {Postoperative bleeding after tonsillectomy - a risk factor study on 28,254 patients}, author = {Engesæter, Ingvild and Bugten, Vegard and Wennberg, Siri and Sunnergren, Ola and Alm, Fredrik and Stalfors, Joacim}, year = {2025}, journal = {Acta Oto-Laryngologica}, volume = {145}, number = {10}, pages = {997--1003}, doi = {10.1080/00016489.2025.2561903}, url = {2001333}, language = {eng}, publisher = {Taylor & Francis}, keywords = {postoperative bleeding; haemostatic technique; surgical technique; tonsil register; tonsillectomy}, abstract = {BACKGROUND: Postoperative bleeding after tonsillectomy is a potentially serious complication. Cold techniques reduce bleeding risks, but hot techniques remain widely used, reflecting national variations in clinical practice.AIMS/OBJECTIVES: This study aimed to investigate postoperative bleeding rates after tonsillectomy and their correlation with demographic factors and surgical and haemostatic techniques, using data from national tonsil surgery registries in Norway and Sweden.MATERIALS AND METHODS: A prospective cohort study included 28,254 tonsillectomies (2017-2022), with patients completing a 30-day postoperative questionnaire. Data on indication for surgery, surgical and haemostatic technique and postoperative bleeding were analyzed using multivariate logistic regression.RESULTS: Postoperative bleeding was reported in 7.2% of the patients, with higher rates in Norway (8.1%) compared to Sweden (6.3%). A hot + hot technique significantly increased the bleeding risk (OR 3.64), while the cold + cold technique had the lowest rate. Patients aged 19-24 years and males had higher bleeding risks.CONCLUSIONS AND SIGNIFICANCE: The cold + cold technique significantly reduces postoperative bleeding, but the cold + hot technique remains the most utilized approach. Norway performed more surgeries in high-risk age groups and had less frequent use of the cold + cold technique compared to Sweden. Increased adoption of the cold + cold technique may improve outcome in tonsil surgery.}, issn = {0001-6489} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_matrnemarie_2025_1, title = {Post-stroke fatigue : The role of comorbidities and its impact on quality of life}, author = {Matérne, Marie and Arvidsson Lindvall, Mialinn and Appelros, Peter and Eriksson, Olivia and Jarl, Gustav}, year = {2025}, journal = {BMC Neurology}, volume = {25}, number = {1}, doi = {10.1186/s12883-025-04143-2}, url = {1954940}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {comorbidity; post-stroke fatigue; quality of life; social factors; stroke}, abstract = {BACKGROUND: Post-stroke fatigue (PSF) is a common complication following stroke that affects approximately 50% of stroke survivors.PURPOSE: The purpose of this study was to investigate the role of comorbidities in PSF and the impact of PSF on Quality of Life (QoL). To achieve this, residual stroke symptoms have also been considered.METHODS: The participants were stroke survivors living in a Swedish municipality. Self-reported data were collected via the Fatigue Assessment Scale (FAS), the Riksstroke questionnaire, and the Short Form Health Survey 36 (SF-36). Linear multiple regression and Spearman's correlation coefficient were used to analyze the data.RESULTS: A total of 142 participants (83 men) with a mean age of 74.8 (SD 9.7) years were included in the study. Fatigue levels were classified as normal (FAS 10-21) for 70 (49.3%) individuals, mild-to-moderate (FAS 22-34) for 56 (39.4%) individuals, and severe (FAS 35-50) for 16 (11.3%) individuals. The mean FAS score was 23.3 (SD 8.2). Multiple regression analysis indicated that the presence of vertigo (β = 0.24, p = 0.004), chronic pulmonary disorders (β = 0.29, p = 0.003), and hemiparesis (β = 0.18, p = 0.05) were associated with more severe PSF. The model explained 19.2% of the variance in PSF. A higher level of PSF was associated with worse QoL in all eight SF-36 domains (r = -0.38 to -0.67).CONCLUSIONS: Vertigo, chronic pulmonary disorders, and hemiparesis were significantly associated with more severe PSF. Additionally, higher levels of fatigue were associated with a worse QoL. These findings confirm that PSF is a multifaceted phenomenon, underscoring the importance of addressing PSF in rehabilitation to improve outcomes for stroke survivors.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_marklundingela_2025, title = {Post-stroke health-related quality of life following lower-extremity constraint-induced movement therapy - An observational survey study}, author = {Marklund, Ingela and Fure, Brynjar and Klässbo, Maria and Liv, Per and Stålnacke, Britt-Marie and Hu, Xiaolei}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {5}, doi = {10.1371/journal.pone.0323290}, url = {1957647}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {Lower- extremity constraint-induced movement therapy (LE-CIMT) has proven effective in overcoming physical disabilities. Participating in the LE-CIMT requires some independent walking ability without aids that indicates a higher level of motor function than for the entire stroke population. However, only few studies evaluated health-related quality of life (HRQoL) after LE-CIMT. This study aimed to compare HRQoL of people who had participated in LE-CIMT post-stroke to the general population and evaluate whether descriptive characteristics and clinical result were associated with their HRQoL. An observational survey study with a questionnaire including the Swedish RAND-36 and Saltin-Grimby Physical Activity Level Scale was sent to 162 people. Reference data from the Mid-Health Survey in Sweden was used for norm-based comparisons of RAND-36. Respondents' result from six-minute walk test post-LE-CIMT were used in the univariate analyse. The response rate was 65% (n = 106; 69 males and 37 females with a mean age of 62 ± 12 years). Ninety percent of the respondents could move around indoors and outdoors independently, despite this, 21% considered themselves physically inactive. The respondents had significantly reduced HRQoL compared to the general population in four of eight domains in the RAND-36: physical functioning (p = 0.001), role-functioning (physical; p < 0.001), general health (p = 0.010), and social functioning (p < 0.001). Regression analysis showed that longer walking distance significantly was associated with the RAND-36 physical functioning domain (β = 6.45, 95% confidence interval = 2.03-10.87, p = 0.005). People in the chronic phase post-stroke who had previously participated in LE- CIMT had reduced HRQoL compared to the general population regarding physical functioning, role-functioning physical, general health, and social functioning. A longer walking distance was associated with higher HRQoL in physical functioning domain, emphasising the importance of mobility training in post-stroke rehabilitation.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_barkerruchtinatalie_2025_3, title = {Potential outcomes of interpersonal violence for women's artistic gymnasts : a qualitative analysis}, author = {Barker-Ruchti, Natalie}, year = {2025}, journal = {British Journal of Sports Medicine}, volume = {59}, number = {19}, pages = {1359--1366}, doi = {10.1136/bjsports-2025-110089}, url = {1990443}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {disclosure; gymnastics; qualitative research; women in sport}, abstract = {OBJECTIVE: This study aimed to identify, map and provide insight into the potential outcomes former elite-level women's gymnasts associate with their history of interpersonal violence (IV).METHODS: The study used a trauma-informed qualitative approach. The sample criterion was women's gymnasts, who had spoken out about IV through social and/or traditional media since the release of the documentary Athlete A. Recruitment occurred purposively through social media; data were generated through online life-history interviews. The interview transcripts were analysed via a hybrid inductive/deductive thematic analysis.RESULTS: The study sample included 18 former elite-level women's artistic gymnasts and one former elite-level rhythmic gymnast, aged 20-53, from 12 countries across four continents. The former gymnasts recounted extensive polyvictimisation by their coaches during formative years, which they associated with 54 potential negative and 7 potential not categorically negative outcomes. Their descriptions of the experiences indicate extensive and complexly interconnected potential psychological, behavioural, physical and material/performance outcomes. The younger, recently retired former gymnasts described their experiences in acute terms, the older former gymnasts recounted recurring and new outcomes. The public discourse on IV in women's gymnastics was acknowledged to have facilitated the development of not categorically negative outcomes.CONCLUSION: The study provides an overview of potential negative and not categorically negative outcomes of IV for women's artistic gymnasts. The insights allow a nuanced understanding of the long-lasting impact of IV, which can raise awareness and inform education, research and care protocols for victims of IV in sport.}, issn = {0306-3674} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dongbo_2025, title = {PPARδ-87T/C plays a critical role in the development of colorectal cancer}, author = {Dong, Bo and Yang, Lie and Yang, Bin and Zhou, Bin and Niu, Ben and Wang, Taiqi and Xu, Zhaowan and Zhu, Lin and Hu, Guang and Meng, Wenjian and Zhang, Hong and Zhou, Zongguang and Sun, Xiaofeng}, year = {2025}, journal = {Chinese Medical Journal}, volume = {138}, number = {23}, pages = {3209--3211}, doi = {10.1097/CM9.0000000000003860}, url = {2016196}, language = {eng}, publisher = {Wolters Kluwer}, issn = {0366-6999} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_merinojosel_2025, title = {Practical Compendium of Antiarrhythmic Drugs : A Clinical Consensus Statement of the European Heart Rhythm Association of the ESC}, author = {Merino, Jose L. and Tamargo, Juan and Blomström-Lundqvist, Carina and Boriani, Giuseppe and Crijns, Harry J G M and Dobrev, Dobromir and Goette, Andreas and Hohnloser, Stefan H. and Naccarelli, Gerald V. and Reiffel, James A. and Tfelt-Hansen, Jacob and Martínez Cossiani, Marcel and Camm, A. John}, year = {2025}, journal = {Europace}, volume = {27}, number = {8}, doi = {10.1093/europace/euaf076}, url = {1948865}, language = {eng}, publisher = {Oxford University Press}, keywords = {adverse drug reactions; antiarrhythmic drug combinations; antiarrhythmic drugs; arrhythmia; atrial fibrillation; drug interactions; mechanisms; pharmacology; ventricular arrhythmias}, abstract = {The EHRA Practical Compendium of Antiarrhythmic Drugs (AADs) offers advice on these drugs, focusing on their clinical use and the global impact of cardiac arrhythmias. This document aims to provide practical instructions to clinicians in arrhythmia management through pharmacological strategies. The compendium highlights persistent challenges in arrhythmia treatment, including clinical constraints, procedural risks, and the complexity of certain arrhythmias. Notably, atrial fibrillation is highly prevalent, and the demand for invasive treatment often surpasses the capacity of existing healthcare systems. As a result, pharmacological management remains essential. This is particularly relevant for patients with cardiac implantable electronic devices or channelopathies, where ablation is often not a suitable option. AADs play a pivotal role in these scenarios. The compendium introduces the ABC framework for AAD therapy: A (Appropriate therapy), for patients in whom AADs are the best therapeutic option, B (Backup therapy), as adjunctive treatment to invasive procedures, such as catheter ablation, and C (Complementary therapy), in combination with other therapies. The document provides detailed insights into the mechanisms of action, efficacy, safety profiles, and drug interactions of each class of AADs. Additionally, the compendium covers practical considerations, including initiation, combination strategies, monitoring, follow-up, special populations, and adverse effect management, with an emphasis on proarrhythmia risk mitigation. It also explores the integration of AADs with other therapeutic modalities, promoting a synergistic approach to optimize patient outcomes. In summary, this compendium serves as an indispensable resource for clinicians, offering practical advice and evidence-based insights to navigate the complexities of arrhythmia management effectively.}, issn = {1099-5129} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisioannis_2025_11, title = {Practical insights for the clinical implementation of the EULAR recommendations for patients with systemic lupus erythematosus}, author = {Parodis, Ioannis and Fanouriakis, Antonis and Bortoluzzi, Alessandra and Iking-Konert, Christof and Weinmann-Menke, Julia and San Román, Carmen and Levy, Roger Abramino and Rua-Figueroa, Inigo and Alexander, Tobias and Amoura, Zahir}, year = {2025}, journal = {RMD Open}, volume = {11}, number = {4}, doi = {10.1136/rmdopen-2025-006210}, url = {2026021}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {biological therapy; glucocorticoids; lupus erythematosus; systemic; lupus nephritis; treatment}, abstract = {OBJECTIVES: The European Alliance of Associations for Rheumatology (EULAR) recommendations for the management of systemic lupus erythematosus (SLE) and lupus nephritis provide important guidance for practitioners on diagnosis, monitoring and treatment. However, practical barriers, such as time constraints, may pose challenges to practitioners when implementing these recommendations in real-world settings. We provide practical, expert-driven advice on how practitioners may effectively and efficiently implement the EULAR recommendations in routine clinical practice.METHODS: Eight international SLE experts convened and contributed opinions and advice for practitioners via an online survey containing 17 open-ended questions on implementation of the EULAR recommendations for early diagnosis, treatment targets and the use of glucocorticoids (GCs), immunosuppressants and biologics. Survey results were compiled and analysed to reach consensus on key advice points for each topic.RESULTS: Expert advice covered four key topics-setting standardised targets to help modify disease course and prevent organ damage; taking action to achieve these targets; monitoring of target achievement through validated clinical tools and frameworks; and optimising the therapeutic strategy to prevent flares and GC-associated toxicities. A total of 13 core expert-driven advice points were developed across these topics, including scenarios for consideration of earlier biological and/or conventional immunosuppressive use, specific risk factors for poorer prognosis to inform treatment decisions and suggestions on GC tapering.CONCLUSIONS: These expert insights could facilitate implementation of the EULAR recommendations for the management of SLE in clinical practice, thereby helping patients achieve treatment targets and prevent and/or delay organ damage progression.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bleniuskarin_2025, title = {Practical skills taught in Scandinavian nursing education simulation centres : a cross-sectional survey}, author = {Bölenius, Karin and Stenholt, Britta Vesterager and Bjørk, Ida Torunn and Reierson, Inger Ase and Blomberg, Karin and Husebø, Sissel Eikeland and Ravik, Monika}, year = {2025}, journal = {Scandinavian Journal of Educational Research}, volume = {69}, number = {7}, pages = {1416--1429}, doi = {10.1080/00313831.2024.2419511}, url = {1912173}, language = {eng}, publisher = {Routledge}, keywords = {cross-sectional; education; practical skills; simulation centres}, abstract = {Practical nursing skills are complex actions that must be taught in bachelor nursing education. There is a lack of comparative research about what simulation-based skills are taught in Scandinavian countries, and this study aims to fill this gap. In 2019, a cross-sectional survey of nursing educators was conducted, and data were analysed using descriptive and non-parametric tests. The study revealed that eight categories of simulation-based practical skills (respiration, activity, elimination, nutrition, skin care, circulation, hygiene, and medication) were taught in all Scandinavian countries, but there were differences in what skills were prioritised within each category. Moreover, the study revealed that the amount of time spent on teaching simulation-based practical skills varied across countries and faculties, with Norway and Sweden spending more time teaching simulation-based practical skills than Denmark. The authors recommend that nursing education prioritise and standardise the practical skills taught in simulation centres in all Scandinavian countries.}, issn = {0031-3831} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alshamariaseel_2025, title = {Practices in platelet production : A Nordic perspective (2018-2022)}, author = {Alshamari, Aseel and Nahreen, Tynngård and Ihalainen, Jarkko and Hemminki, Ari and Landrö, Ragna and Knútsdóttir, Erna and Sørensen, Betina and Danilova, Elena and Jacobsen, Barbora and Auvinen, Marja-Kaisa and Ramström, Sofia and Abedi, Mohammad R.}, year = {2025}, journal = {Vox Sanguinis}, doi = {10.1111/vox.70163}, url = {2024104}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {nordic region; bacterial culture screening; pathogen reduction; platelet concentrate; platelets}, abstract = {BACKGROUND AND OBJECTIVES: The Nordic region includes Denmark, Finland, Iceland, Norway and Sweden, with a population of >27.5 million. Blood services are managed differently in each country. Current data on platelet concentrate (PC) production methods and capacity are important for developing efficiency and cross-border preparedness.MATERIALS AND METHODS: Retrospective data for 2018-2022 were collected through an online survey sent to all blood centres producing platelets in the region. Questions focused on collection procedures (aphaeresis [AP] or whole blood [WB]-derived pools), use of bacterial culture screening (BCS) or pathogen reduction (PR), shelf-life, transfusion practices and quality control.RESULTS: A total of 43 blood centres provided data (83% response), including complete national coverage for Sweden, Finland and Iceland. Between 2018 and 2022, 632,596 PCs were produced at participating centres. Annual PC production was stable over the period. Most PCs were WB pools (77%). Automated separation to produce interim platelet unit (IPU) pools was performed at 19 centres. PR and BCS were used in 17 and 23 centres, respectively. Shelf-life ranged from 5 days (no safety measure) to 7 days (PR or BCS). The number of PCs transfused in the region declined by ~5% from 2018 to 2022.CONCLUSION: Platelet production methods, including safety measures to prevent bacterial contamination, varied widely in the Nordic region. Harmonization, including the use of PR or BCS with 7-day storage, may contribute to resilient platelet supplies in the region.}, issn = {0042-9007} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nordlieemilia_2025, title = {Precision and prediction matter : investigating hearing recovery measurements and prognosis in sudden sensorineural hearing loss}, author = {Nordlie, Emilia and Elander, Johanna and Värendh, Maria and Stenfeldt, Karin and Tjernström, Fredrik and Gisselsson-Solén, Marie and Sjögren, Julia and Magnusson, Måns and Ehinger, Johannes K.}, year = {2025}, journal = {European Archives of Oto-Rhino-Laryngology}, doi = {10.1007/s00405-025-09675-4}, url = {2004610}, language = {eng}, publisher = {Springer}, keywords = {audiometry; corticosteroids; prognosis; sudden sensorineural hearing loss; treatment}, abstract = {PURPOSE: Sudden sensorineural hearing loss (SSNHL) is defined as 30 decibels (dB) hearing loss in 3 consecutive frequencies occurring within 72 h. Pure-tone average of four frequencies (PTA4) is commonly used to evaluate hearing levels but may not accurately reflect the recovery. We aimed to identify prognostic factors for recovery and to evaluate how recovery should be assessed, by comparing PTA4 with an individual pure-tone average (iPTA), including solely the hearing thresholds for the affected frequencies.METHODS: Demographic, clinical, and audiologic factors were analyzed using multivariable linear and logistic regression models. A Bland-Altman plot was used to compare recovery measurements based on iPTA and PTA4.RESULTS: In this cohort, the mean age was 57 years (range 19-91 years). Dizziness was a prominent negative predictive factor (logistic regression: iPTA OR 0.09 95% CI 0.02-0.38, for full recovery; linear regression: iPTA 14.4 dB poorer recovery). Tinnitus correlated with, on average, 4.9 dB poorer recovery (P=0.043). Each day of delayed assessment was linked to a 0.84 dB reduction in recovery (P <0.001; OR 0.92, 95% CI 0.87-0.98). Comparing PTA4 with iPTA, the Bland-Altman plot showed -2.4 dB mean difference with wide limits of agreement, ranging from approximately -17 to 13 dB. In cases of frequency range-specific hearing loss, hearing recovered 8.7 dB more by using iPTA than PTA4 (P=0.003).CONCLUSION: Dizziness, tinnitus, and increasing disease duration until assessment are negative prognostic factors. Compared to PTA4, iPTA better reflects actual hearing recovery, particularly in frequency range-specific hearing loss.}, issn = {0937-4477} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_jaafarrita_2025_1, title = {Pre-clinical development of a mucosal live-attenuated vaccine for tick-borneencephalitis using the Langat virus platform : Abstracts August 21-23, 2025}, author = {Jaafar, Rita and Asghar, Naveed and Merinder, Olivia and Andreassen, Åshild Kristine and Ljungberg, Karl and Nilsson, Charlotta and Taylor, Travis and Melik, Wessam and Johansson, Magnus}, year = {2025}, url = {1999488}, language = {eng}, keywords = {tbe; lgtv; vaccine; reverse genetics; mucosal immunization}, abstract = {Tick-borne encephalitis (TBE) is a significant disease in Europe and Asia, with a risingincidence due to the spread of the TBE virus (TBEV) and its vectors. Current TBE vaccinesprovide good protection, but they have a complex immunization schedule and lower efficacy inthe elderly, leading to occasional vaccine failures. We aim to develop a novel TBE vaccine toprovide better protection with fewer doses through mucosal immunization. The current workcovers a pilot study that evaluates live-attenuated TBE vaccine in vivo, using Langat virus(LGTV) platform that we developed based on a rescued LGTV infectious clone (LGTV IC).In the current mouse study, LGTV IC was administered via intranasal and intramuscular routesat two doses (10³ and 10⁵ PFU). The study assessed tolerability, viremia profile, and inducedimmunogenicity.As a result, we show that intranasal immunization with LGTV IC induced strong immuneresponses and revealed a favorable safety profile in a dose-dependent manner. Low-doseintranasal administration was well tolerated, with no clinical signs, weight loss, or viral presencein the central nervous system. It elicited robust anti-TBEV IgG antibodies that successfullyneutralized both LGTV and TBEV and induced strong cellular immunity, characterized byTBEV NS3-specific IFNγ and IL-2 secreting cells. Notably, low-dose mucosal immunizationoutperformed both high-dose intranasal and intramuscular administration in generating abalanced immune response. In contrast, high-dose intranasal immunization caused significantweight loss and minimal viral detection in CSF, indicating potential adverse effects at elevateddoses.These findings support the potential of low-dose mucosal immunization with LGTV IC as a safeand effective TBE vaccination strategy. Further attenuation of LGTV IC is underway to enhancesafety for future development.}, file = {https://oru.diva-portal.org/smash/get/diva2:1999488/FULLTEXT01.pdf;https://oru.diva-portal.org/smash/get/diva2:1999488/FULLTEXT02.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_pfarrkenneth_2025, title = {PRE-CLINICAL DEVELOPMENT OF THE ANTI-WOLBACHIAL DRUG CORALLOPYRONIN A TO TREAT FILARIASES : END RUN TO PHASE 1 TRIAL}, author = {Pfarr, Kenneth and Schiefer, Andrea and Rox, Katharina and Risch, Frederic and Shafer, William and Edwards, Jennifer and Unemo, Magnus and Bierbaum, Gabriele and Kehraus, Stefan and Grosse, Miriam and Müller, Rolf and Schneider, Tanja and Hesterkamp, Thomas and Stadler, Marc and Hübner, Marc P. and Wagner, Karl G. and Hoerauf, Achim}, year = {2025}, journal = {American Journal of Tropical Medicine and Hygiene}, volume = {112}, number = {6 Suppl.}, pages = {186--186}, url = {2043183}, language = {eng}, publisher = {HighWire Press}, abstract = {The bacterial RNA polymerase inhibitor Corallopyronin A (CorA) is in late pre-clinical development to treat filariases. As an anti-wolbachial compound, it depletes the essential obligate intracellular Wolbachia symbionts of filarialne matodes, resulting in sterility and death of the worms. Our consortium has achieved the following significant milestones: 1) produced drug substance with >95% purity by heterologous production in Myxococcus xanthus, 2) received formal Scientific Advice from the German regulatory agency BfArM approving our proposed drug substance purity for toxicology studies, 3) upscaled upstream and downstream processes to industrial-scale, 4) developed oral formulations with increased CorA solubility and stability that are suitable for GLP pre-clinical studies and the phase 1 trial, 5) successfully completed non-GLP safety and toxicology studies with no relevant results that would halt development, 6) contracted a cGMP CMO to conduct a feasibility study and perform technical/engineering production runs of GMP material, and 7) expanded development to including difficult-to-treat Staphylococcus aureus and Neisseria gonorrhoeae infections. We have received support from the Global Health Innovative Technology Fund (GHIT) to complete the pre-clinical development: conduct PK/PD in Dirofilaria immitis infection, support a GLP toxicology study in dogs, produce GMP CorA and CorA standards, conduct a quantitative whole-body autoradiography study, perform CMC to further improve the oral formulations, and prepare the phase 1 trial planned for 2026. Successful completion of the phase 1 trial will derisk the project to continue development of CorA for registration.}, issn = {0002-9637} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_grnnolle_2025_1, title = {Preclinical protein signatures of Crohn's disease and ulcerative colitis : A nested case-control study within large population-based cohorts}, author = {Grännö, Olle and Bergemalm, Daniel and Salomon, Benita and Lindqvist, Carl Mårten and Hedin, Charlotte R. H. and Carlson, Marie and Dannenberg, Katharina and Andersson, Erik and Keita, Åsa V. and Magnusson, Maria K. and Eriksson, Carl and Lanka, Vivekananda and Magnusson, Patrik Ke and D'Amato, Mauro and Öhman, Lena and Söderholm, Johan D. and Hultdin, Johan and Kruse, Robert and Cao, Yang and Repsilber, Dirk and Grip, Olof and Karling, Pontus and Halfvarson, Jonas}, year = {2025}, journal = {Gastroenterology}, volume = {168}, number = {4}, pages = {741--753}, doi = {10.1053/j.gastro.2024.11.006}, url = {1920506}, language = {eng}, publisher = {American Gastroenterology Association Institute}, keywords = {crohn’s disease; preclinical disease; inflammatory bowel disease; proteomics; ulcerative colitis}, abstract = {BACKGROUND AND AIMS: Biomarkers are needed to identify individuals at elevated risk of inflammatory bowel disease (IBD). This study aims to identify protein signatures predictive of IBD.METHODS: Using large population-based cohorts (n≥180,000), blood samples were obtained from individuals who later in life were diagnosed with IBD and compared to age and sex-matched controls, free from IBD during follow-up. 178 proteins were measured on Olink platforms. We used machine learning methods to identify protein signatures of preclinical disease in the discovery cohort (n=312). Their performance was validated in an external preclinical cohort (n=222) and assessed in an inception cohort (n=144) and a preclinical twin cohort (n=102).RESULTS: In the discovery cohort, a signature of 29 proteins differentiated preclinical Crohn's disease (CD) cases from controls, with an area under the curve (AUC) of 0.85. Its performance was confirmed in the preclinical validation (AUC=0.87) and the inception cohort (AUC=1.0). In preclinical samples, downregulated (but not upregulated) proteins related to gut barrier integrity and macrophage functionality correlated with time to diagnosis of CD. The preclinical ulcerative colitis (UC) signature had a significant, albeit lower, predictive ability in the discovery (AUC=0.77), validation (AUC=0.67), and inception cohorts (AUC=0.95). The preclinical signature for CD demonstrated an AUC of 0.89 when comparing twins with preclinical CD to matched external healthy twins, but its predictive ability was lower (AUC=0.58; P=.04) when comparing them with their healthy twin siblings, i.e., when accounting for genetic and shared environmental factors.CONCLUSION: We identified protein signatures for predicting a future diagnosis of CD and UC, validated across independent cohorts. In the context of CD, the signature offers potential for early prediction.}, issn = {0016-5085} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lahoudalanalis_2025, title = {Predict-and-Optimize Techniques for Data-Driven Optimization Problems : A Review}, author = {Lahoud, Alan Alis and Khan, Ahmad Saeed and Schaffernicht, Erik and Trincavelli, Marco and Stork, Johannes Andreas}, year = {2025}, journal = {Neural Processing Letters}, volume = {57}, number = {2}, doi = {10.1007/s11063-025-11746-w}, url = {1953861}, language = {eng}, publisher = {Springer}, keywords = {neural networks; constrained optimization; decision making; machine learning; optimization problems}, abstract = {Machine learning predictive models rely on data to make predictions for new input data. However, accurate predictions are not always the end goal; practitioners often aim to make informed decisions through optimization problems (OPs) based on these predictions. While the idea that better predictions lead to better decisions was widely accepted, the latest literature highlights that even small inaccuracies in predictions can lead to poor decisions depending on the structure of the OP. Therefore, recent research has been focused on end-to-end learning approaches that directly improve decision quality without considering prediction accuracy when solving data-driven OPs. Some of these end-to-end learning approaches are mainly called "predict-and-optimize" (PaO), and they aim to learn a predictor based on the quality of the downstream task decisions by incorporating mathematical programming into the learning process. This literature review discusses the variations of and approaches to PaO problems by proposing a unified notation and a taxonomy for them. Throughout the paper, we aim to provide a valuable roadmap for researchers and practitioners in the field, guiding them to choose data-driven methods to solve their decision problems effectively.}, issn = {1370-4621} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bottojoo_2025, title = {Predicting EQ-5D full health state in systemic lupus erythematosus using machine learning algorithms}, author = {Botto, João and Cetrez, Nursen and Nikolopoulos, Dionysis and Regardt, Malin and Heintz, Emelie and Lindblom, Julius and Parodis, Ioannis}, year = {2025}, journal = {Rheumatology: Advances in Practice}, volume = {9}, number = {2}, doi = {10.1093/rap/rkaf032}, url = {1954433}, language = {eng}, publisher = {Oxford University Press}, keywords = {eq-5d; machine learning; patient-reported outcomes; quality of life; systemic lupus erythematosus}, abstract = {OBJECTIVES: To determine factors associated with reports of EuroQol 5-Dimensions (EQ-5D) full health state (FHS) before and after a trial intervention in patients with SLE, resorting to machine learning algorithms.METHODS: We conducted a post hoc analysis of two phase 3 clinical trials of belimumab (BLISS-52, BLISS-76). Demographic, laboratory and clinical features were retrieved and the Monte Carlo Feature Selection algorithm was employed, then further refined upon consideration of collinearity and clinical relevance. We used support vector machine with radial basis function kernel (SVMRadial), least absolute shrinkage and selection operator (LASSO), neural network (NNet) and logistic regression (LR) to capture both linear and non-linear relationships while ensuring interpretability and robustness.RESULTS: Among 1642 SLE patients, 12.9% reported FHS at baseline and 23.1% at week 52. Selected features were age, sex, Asian ancestry, baseline cSLEDAI-2K, SELENA-SLEDAI PGA, and urine protein:creatinine ratio (UPCR) and baseline EQ-5D 3-Levels (EQ-5D-3L) index score (week 52 models only). The models predicting FHS demonstrated comparable performance at baseline and week 52. A maximum area under the curve of 0.73 was seen for the baseline LASSO and LR models and a maximum of 0.77 for the week 52 LASSO and NNet models. Negative predictive values were high for all models (0.88-0.94). Calibration showed marginal improvement in week 52 models.CONCLUSION: Machine learning identified older age, female sex, non-Asian ancestry, high disease activity and low UPCR to be associated with a lack of FHS experience in SLE patients at baseline and week 52. High baseline EQ-5D-3L index scores constituted the strongest predictor of FHS at week 52.TRIAL REGISTRATION: The BLISS-52 and BLISS-76 trials are registered at www.clinicaltrials.gov (NCT00424476 and NCT00410384, respectively).} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_holmsebastian_2025_2, title = {Predicting Postoperative Complications in Older Patients Undergoing Head and Neck Microvascular Reconstruction Using the National Quality Improvement Program Risk Calculator}, author = {Holm, Sebastian and Löfgren, Jenny and Zdolsek, Johann and Berner, Juan Enrique and Landström, Fredrik}, year = {2025}, journal = {Plastic and Reconstructive Surgery - Global Open}, volume = {13}, number = {6}, doi = {10.1097/GOX.0000000000006910}, url = {1979147}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, abstract = {BACKGROUND: Head and neck cancer (HNC) is the seventh most prevalent cancer worldwide, usually requiring a multidisciplinary approach. The National Surgical Quality Improvement Program (NSQIP) risk calculator is a tool for predicting postoperative complications that possibly can help in decision-making, support patient education, and guide the choice between surgical and nonsurgical treatment options. The aim of this study was to assess the reliability of the NSQIP risk calculator as a predictor of postoperative complications following head and neck surgery with microvascular reconstruction.METHODS: This retrospective study included 99 patients diagnosed with HNC who underwent microvascular reconstruction from January 2016 to February 2021. The observed complications were compared with those predicted by the NSQIP calculator. To assess the discriminatory power of the NSQIP estimates, receiver operating characteristic statistics, logistic regression, and the overall Brier score were used.RESULTS: Forty-four percent of the patients experienced at least 1 postoperative complication, and 27.2% developed serious complications. The receiver operating characteristic analysis for any complications revealed an area under the curve (AUC) of 0.62 (95% confidence interval 0.51-0.73, P = 0.046). For serious complications, the AUC was 0.65 (95% confidence interval, 0.52-0.79, P = 0.021). Both AUC values fell short of the threshold for "acceptable discrimination" (0.7-0.8). The overall Brier score was 0.32, with scores less than 0.09 considered to have good accuracy.CONCLUSIONS: The results suggest that the NSQIP risk calculator tends to underestimate the likelihood of postoperative complications in patients who are undergoing resection for HNC accompanied by microvascular reconstruction.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rysstadtarjei_2025, title = {Predicting prolonged work absence due to musculoskeletal disorders : development, validation, and clinical usefulness of prognostic prediction models}, author = {Rysstad, Tarjei and Grotle, Margreth and Traeger, Adrian C. and Aasdahl, Lene and Vigdal, Ørjan Nesse and Aanesen, Fiona and Øiestad, Britt Elin and Pripp, Are Hugo and Wynne-Jones, Gwenllian and Dunn, Kate M. and Fors, Egil A. and Linton, Steven J. and Tveter, Anne Therese}, year = {2025}, journal = {International Archives of Occupational and Environmental Health}, volume = {98}, pages = {385--397}, doi = {10.1007/s00420-025-02129-8}, url = {1951468}, language = {eng}, publisher = {Springer}, keywords = {clinical utility; external validation; multivariable logistic regression; musculoskeletal disorders; prediction model; prolonged work absence}, abstract = {PURPOSE: Given the lack of robust prognostic models for early identification of individuals at risk of work disability, this study aimed to develop and externally validate three models for prolonged work absence among individuals on sick leave due to musculoskeletal disorders.METHODS: We developed three multivariable logistic regression models using data from 934 individuals on sick leave for 4-12 weeks due to musculoskeletal disorders, recruited through the Norwegian Labour and Welfare Administration. The models predicted three outcomes: (1) > 90 consecutive sick days, (2) > 180 consecutive sick days, and (3) any new or increased work assessment allowance or disability pension within 12 months. Each model was externally validated in a separate cohort of participants (8-12 weeks of sick leave) from a different geographical region in Norway. We evaluated model performance using discrimination (c-statistic), calibration, and assessed clinical usefulness using decision curve analysis (net benefit). Bootstrapping was used to adjust for overoptimism.RESULTS: All three models showed good predictive performance in the external validation sample, with c-statistics exceeding 0.76. The model predicting > 180 days performed best, demonstrating good calibration and discrimination (c-statistic 0.79 (95% CI 0.73-0.85), and providing net benefit across a range of decision thresholds from 0.10 to 0.80.CONCLUSIONS: These models, particularly the one predicting > 180 days, may facilitate secondary prevention strategies and guide future clinical trials. Further validation and refinement are necessary to optimise the models and to test their performance in larger samples.}, issn = {0340-0131} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_forsstenmaximilianpeter_2025_1, title = {Prediction of Amputation Following Severe Pediatric Lower Extremity Injury : Application of the Mangled Lower Extremity (MangLE) Score in a Pediatric Population}, author = {Forssten, Maximilian Peter and Ekestubbe, Lovisa and Coimbra, Bruno and Cao, Yang and Sarani, Babak and Mohseni, Shahin}, year = {2025}, journal = {The American surgeon}, doi = {10.1177/00031348251383480}, url = {2001328}, language = {eng}, publisher = {Sage Publications}, keywords = {mangle score; amputation; mangled lower extremity; pediatric}, abstract = {Background: Severe lower extremity injuries in pediatric patients present significant challenges for surgeons deciding between repair and amputation. A novel scoring system, the MangLE score, has been developed to identify adult patients who are unlikely to require amputation after severe lower extremity injury. This study sought to evaluate the predictive ability of the MangLE score in pediatric patients.Methods: A retrospective analysis was conducted using the 2013-2021 American College of Surgeons Trauma Quality Improvement Program (TQIP) database. Pediatric patients (≤17 years) with mangled lower extremities were included. Patients were stratified into age groups (0-3, 4-9, 10-13, and 14-17 years), and the predictive ability of the MangLE score for lower extremity amputation was assessed based on the area under the receiver operating characteristic curve (AUC), sensitivity, and specificity.Results: A total of 7959 patients met the inclusion criteria. The MangLE score demonstrated an excellent predictive capability in patients aged 10-13 (AUC (95% CI): 0.87 (0.79-0.94)) and 14-17 (AUC (95% CI): 0.83 (0.79-0.86)). At the cutoff of ≥8, this resulted in an NPV of 99.7% for 10-13-year-olds and 99.4% for 14-17-year-olds. However, the MangLE score was ineffective in discriminating between those who did and did not require a lower extremity amputation in patients between 0 and 9 years old.Discussion: The MangLE score maintains an excellent predictive ability for identifying those unlikely to require lower extremity amputation in pediatric mangled extremity patients aged 10-17; however, it fails to accurately predict this outcome in younger patients. Level of Evidence Level IV.}, issn = {0003-1348} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_norinderulf_2025, title = {Prediction of the classification, labelling and packaging regulation H-statements with confidence using conformal prediction with N-grams and molecular fingerprints}, author = {Norinder, Ulf and Zheng, Ziye and Cotgreave, Ian}, year = {2025}, journal = {Current research in toxicology}, volume = {8}, doi = {10.1016/j.crtox.2025.100242}, url = {1969893}, language = {eng}, publisher = {Elsevier}, keywords = {clp regulation; conformal prediction; consensus modeling; h -statements; molecular fingerprints; n -grams; random forest}, abstract = {Effective chemical hazard labelling systems are essential for safeguarding human health and the environment as a result of widespread chemical use, and machine-learning models can be used to predict hazard labels efficiently and reduce the use of animal tests. This investigation shows the utility of N-grams and other fingerprint featurization procedures for predicting classification, labelling and packaging (CLP). Regulation H-statements, particularly in an ensemble (consensus) setting. Consensus modelling by class or Conformal Prediction median pvalues seems to be particularly advantageous in order to obtain both high conformal prediction validity and efficiency as well as good balanced accuracy, sensitivity and specificity. Utilization of the N-grams allows handling of all symbols in SMILES strings including those related to metals and salts that may be important for the compounds to exhibit their experimental determined toxicities. The models developed in this study are efficient tools to access hazard classification H-statements of chemicals, which can be useful for chemical hazard assessment, read-across as well as risk management.}, issn = {2666-027X} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_alkhatibamr_2025, title = {Prediction via Shapley Value Regression}, author = {Alkhatib, Amr and Bresson, R. and Boström, H. and Vazirgiannis, M.}, year = {2025}, volume = {267}, pages = {1056--1101}, url = {2028993}, language = {eng}, publisher = {ML Research Press}, abstract = {Shapley values have several desirable, theoretically well-supported, properties for explaining black-box model predictions. Traditionally, Shapley values are computed post-hoc, leading to additional computational cost at inference time. To overcome this, a novel method, called ViaSHAP, is proposed, that learns a function to compute Shapley values, from which the predictions can be derived directly by summation. Two approaches to implement the proposed method are explored; one based on the universal approximation theorem and the other on the Kolmogorov-Arnold representation theorem. Results from a large-scale empirical investigation are presented, showing that ViaSHAP using Kolmogorov-Arnold Networks performs on par with state-of-the-art algorithms for tabular data. It is also shown that the explanations of ViaSHAP are significantly more accurate than the popular approximator FastSHAP on both tabular data and images. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_forsstenmaximilianpeter_2025_2, title = {Predictive ability of frailty scores in surgically managed patients with traumatic spinal injuries : a TQIP analysis}, author = {Forssten, Maximilian Peter and Ekestubbe, Lovisa and Cao, Yang and Mohammad Ismail, Ahmad and Ioannidis, Ioannis and Sarani, Babak and Mohseni, Shahin}, year = {2025}, journal = {European Journal of Trauma and Emergency Surgery}, volume = {51}, number = {1}, doi = {10.1007/s00068-025-02775-0}, url = {1942760}, language = {eng}, publisher = {Urban und Vogel Medien und Medizin Verlagsgesellsc}, keywords = {frailty; hospital frailty risk score; johns hopkins frailty indicator; modified frailty index; morbidity; mortality; orthopedic frailty score; traumatic spinal injury}, abstract = {PURPOSE: Frailty has gained recognition as a crucial determinant of patient outcomes following traumatic spinal injury (TSI), particularly due to its increasing incidence in elderly populations. The aim of the current investigation was therefore to compare the ability of several frailty scores to predict adverse outcomes in surgically managed isolated TSI patients without spinal cord injury.METHODS: All adult patients (18 years or older) who suffered an isolated TSI due to blunt trauma, and required surgical management, were extracted from the 2013-2021 Trauma Quality Improvement Program database. The ability of the Orthopedic Frailty Score (OFS), the Hospital Frailty Risk Score (HFRS), the 11-factor (11-mFI) and 5-factor (5-mFI) modified frailty index, as well as the Johns Hopkins Frailty Indicator to predict adverse outcomes was compared based on the area under the receiver-operating characteristic curve (AUC). Subgroup analyses were also performed on patients who were ≥ 65 years old and those who were injured due to a ground-level fall (GLF).RESULTS: A total of 39,449 patients were selected from the TQIP database. The 5-mFI and 11-mFI outperformed all other frailty scores when predicting in-hospital mortality (5-mFI AUC: 0.73) (11-mFI AUC: 0.73), any complication (5-mFI AUC: 0.65) (11-mFI AUC: 0.65), and FTR (5-mFI AUC: 0.75) (11-mFI AUC: 0.75). Among the 14,257 geriatric patients, however, the OFS demonstrated the highest predictive ability for in-hospital mortality (AUC: 0.65). The OFS (AUC: 0.64) also performed on the same level as both the 5-mFI (AUC: 0.63) and the 11-mFI (AUC: 0.63) when predicting FTR in this population. Among the 9616 patients who were injured due to a GLF, the OFS performed on par with the 5-mFI and 11-mFI when predicting in-hospital mortality and FTR.CONCLUSION: Simpler scores like the 5-factor modified Frailty Index and Orthopedic Frailty Score outperform or perform on par with more complicated frailty scores when predicting mortality, complications, and failure-to-rescue in surgically managed isolated traumatic spinal injury patients without spinal cord injury, particularly among geriatric patients and those injured in a GLF.}, issn = {1863-9933} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sunnhedrikard_2025, title = {Predictors and moderators of cognitive therapy and behavior therapy for insomnia disorder}, author = {Sunnhed, Rikard and Hesser, Hugo and Carlbring, Per and Harvey, Allison G. and Jansson-Fröjmark, Markus}, year = {2025}, journal = {Sleep Medicine}, volume = {133}, doi = {10.1016/j.sleep.2025.106611}, url = {1969941}, language = {eng}, publisher = {Elsevier}, keywords = {behavior therapy; cognitive therapy; insomnia; moderators; personalized medicine}, abstract = {INTRODUCTION: Little is known about what pretreatment patient characteristics the outcome of Cognitive Therapy (CT) and Behavioral Therapy (BT) for insomnia disorder depends on. Identifying for whom treatment is most useful is essential for treatment optimization and personalized care. Therefore, this investigation aimed to examine both theory-driven constructs and insomnia-associated clinical variables as potential predictors and moderators of outcomes in CT and BT.MATERIALS AND METHODS: One hundred forty-five participants diagnosed with insomnia disorder were randomly assigned to 10 weekly internet-delivered modules of CT or BT, along with 15 min of weekly telephone support. General clinical predictors and theory-driven moderators (cognitive and behavioral processes) assessed in a previous randomized controlled trial were analyzed using multiple linear regression, with insomnia severity as the outcome.RESULTS: Bedtime variability and early morning awakening interacted with treatment and indicated that lower bedtime variability and early morning awakening were associated with a higher effect for CT, whereas the opposite was true for BT. Wake time after sleep onset, insomnia severity index, and sleep efficiency emerged as predictors, indicating prognostic value for treatment outcome.CONCLUSIONS: In addition to identifying three insomnia-associated variables as predictors of outcome across both treatments, this trial showed that CT and BT could be differentially effective based on patient insomnia heterogeneity at baseline. The differential moderator findings are in line with the theoretical models of CT and BT and might clinically implicate the ability to match therapy to patient features to optimize outcomes.}, issn = {1389-9457} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mahomedasmailfaheema_2025, title = {Predictors of hearing loss disability : a multinational study using the ICF core set}, author = {Mahomed-Asmail, Faheema and Graham, Marien Alet and Swanepoel, De Wet and Manchaiah, Vinaya and Yerraguntla, Krishna and Karlsson, Elin}, year = {2025}, journal = {International Journal of Audiology}, volume = {64}, number = {8}, pages = {784--791}, doi = {10.1080/14992027.2025.2458029}, url = {1936503}, language = {eng}, keywords = {icf; self-experience; associated predictors; disability; hearing loss}, abstract = {Purpose: Objective audiological assessments provide valuable insights on physiological dimensions of hearing loss (HL), but not on lived experiences and functional limitations perceived by individuals. This study employed the multidimensional ICF framework to explore how demographic and diagnostic variables predict self-reported disability in adults with HL.Method: This cross-sectional study included 571 participants from India (94), South Africa (79), Sweden (219), and the USA (179). Responses from structured interviews based on the ICF were measured against demographic and diagnostic variables.Results: 74.6% of the participants were hearing aid (HA) users with moderate-to-severe HL. Five statistically significant predictors were identified; HA usage, degree of HL, level of education, age, and income bracket. The predictors were associated with the ICF components; body functions (b126, b210, b230, b240), activity and participation (d310, d350) and environmental factors (e125, e250, e310, e355, e410, e460).Conclusions: This study emphasises that an individual's experience with HL is significantly influenced by various factors beyond the severity of the HL itself. This underscores the ICF's utility in capturing the complex interplay of biopsychosocial factors on HL. Identifying significant predictors could aid in tailoring interventions to improve health outcomes and quality of life for individuals with HL.}, issn = {1499-2027} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gurgelwagner_2025, title = {Predictors of preschool attention-deficit/hyperactivity disorder diagnosis : a population-based study using national registers}, author = {Gurgel, Wagner and Garcia-Argibay, Miguel and D’Onofrio, Brian M. and Larsson, Henrik and Polanczyk, Guilherme V.}, year = {2025}, journal = {Journal of Child Psychology and Psychiatry}, volume = {66}, number = {6}, pages = {834--845}, doi = {10.1111/jcpp.14093}, url = {1921411}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {adhd; child; preschool; cohort studies; survival analysis; comorbidity}, abstract = {Background: The diagnosis of attention-deficit/hyperactivity disorder (ADHD) in preschool years (before age 6 years) is a marker of severity and poor prognosis. This study investigated a broad range of predictors of ADHD diagnosis during preschool age.Methods: Population-based cohort study using Swedish registers. The final sample consisted of all children born in Sweden between 2001 and 2007 who could be linked to both of their biological parents, excluding those who died or emigrated (n = 631,695). Follow-up was completed December 31, 2013. Cox proportional-hazards models for survival analysis were used to identify the predictors that increased the risk of receiving a clinical diagnosis of ADHD from 3 to 5 years. Hazard ratios (HR) with 95% confidence intervals (CI) were presented for each of the 41 selected predictors covering early-onset psychiatric comorbidities, nonpsychiatric medical conditions, parental history and perinatal factors.Results: At the end of follow-up, 1,686 preschoolers (2.7% of the whole sample) had received a diagnosis of ADHD. We found that 39 out of 41 predictors were associated with increased risk of a later diagnosis of preschool ADHD. Novel associations with preschool ADHD diagnosis were found for gastroesophageal reflux disease (HR = 3.48), premature contractions during pregnancy (HR = 2.03), and criminal conviction history from any parent (HR = 2.14).Conclusions: A large number of novel and well-established predictors of preschool ADHD diagnosis were identified. This broad set of early predictors may direct future clinical research and assist in early identification of preschool ADHD.}, issn = {0021-9630} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jgerbacksandra_2025, title = {Predictors of renal flares in systemic lupus erythematosus : a post-hoc analysis of four phase III clinical trials of belimumab}, author = {Jägerback, Sandra and Gomez, Alvaro and Parodis, Ioannis}, year = {2025}, journal = {Rheumatology}, volume = {64}, number = {2}, pages = {623--631}, doi = {10.1093/rheumatology/keae023}, url = {1827609}, language = {eng}, publisher = {Oxford University Press}, keywords = {belimumab; biologics; biomarkers; renal flares; systemic lupus erythematosus}, abstract = {OBJECTIVES: To identify predictors of renal flares in patients with SLE treated for active extra-renal disease.METHODS: Data from four clinical trials of belimumab in SLE (BLISS-52, NCT00424476; BLISS-76, NCT00410384; BLISS-NEA, NCT01345253; BLISS-SC, NCT01484496) were used. Patients were assigned to belimumab or placebo on top of standard therapy. We investigated the performance of predictors of renal flares through 52-76 weeks using proportional hazards regression analysis.RESULTS: Of 3225 participants, 192 developed at least one renal flare during follow-up, with the first occurring after a median time of 197 days. Current/former renal involvement (HR: 15.4; 95% CI: 8.3-28.2; p< 0.001), low serum albumin levels (HR 0.9; 95% CI: 0.8-0.9; p< 0.001), proteinuria (HR: 1.6; 95% CI: 1.5-1.7; p< 0.001), and low C3 levels (HR: 2.9; 95% CI: 2.1-4.1; p< 0.001) at baseline appeared robust determinants of renal flares. Anti-dsDNA positivity yielded an increased hazard for renal flares (HR: 2.1; 95% CI: 1.4-3.2; p< 0.001), which attenuated after adjustments. Anti-Sm positivity was associated with renal flares in the placebo (HR: 3.7; 95% CI: 2.0-6.9; p< 0.001) but not in the belimumab subgroup, whereas anti-ribosomal P positivity was associated with renal flares in the belimumab subgroup only (HR: 2.8; 95% CI: 1.5-5.0; p= 0.001).CONCLUSION: A history of renal involvement, high baseline proteinuria, hypoalbuminaemia, and C3 consumption were robust determinants of impending renal flares. Beyond anti-dsDNA, anti-Sm and anti-ribosomal P protein antibody positivity may have value in surveillance of renal SLE.}, issn = {1462-0324} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ljunggrenmirjamelisa_2025_1, title = {Predictors of residual sleepiness in CPAP treated obstructive sleep apnea}, author = {Ljunggren, Mirjam Elisa and Ekstrom, Magnus and Emilsson, Ossur Ingi and Grote, Ludger and Sundh, Josefin and Theorell-Haglow, Jenny and Palm, Andreas}, year = {2025}, journal = {European Respiratory Journal}, volume = {66}, number = {Suppl. 69}, doi = {10.1183/13993003.congress-2025.PA5628}, url = {2039374}, language = {eng}, publisher = {European Respiratory Society}, issn = {0903-1936} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_keflolinda_2025, title = {Prehabilitation for radiotherapy-induced vaginal and sexual health issues : Women's experiences of a novel intervention}, author = {Åkeflo, Linda and Höynä Wessberg, Josefin and Goldkuhl, Lisa and Elmerstig, Eva and Blomqvist, Emelie and Fessé, Per and Kunni, Kristin and Langegård, Ulrica and Ohlsson-Nevo, Emma and Sjövall, Katarina and Örmon, Karin and Ahlberg, Karin}, year = {2025}, journal = {European Journal of Oncology Nursing}, volume = {79}, doi = {10.1016/j.ejon.2025.103011}, url = {2010733}, language = {eng}, publisher = {Elsevier}, keywords = {pelvic cancer; prehabilitation; radiotherapy; sexual health; thematic analysis; vaginal dilator therapy; vaginal stenosis}, abstract = {PURPOSE: This study explores women's experiences of a novel prehabilitation intervention, integrating early vaginal dilator therapy before and during pelvic radiotherapy.METHODS: This qualitative study included sixteen women scheduled for pelvic radiotherapy. All participants received a pre-treatment intervention with individualized information and support to start vaginal dilator therapy prior to radiotherapy. Semi-structured interviews were conducted with all sixteen women before or during treatment. Of these, ten also participated in follow-up interviews after radiotherapy. Data were analyzed using reflexive thematic analysis.RESULTS: Four themes were constructed reflecting women's experiences of the new prehabilitation intervention: (1) Regaining control while facing the unknown, (2) Navigating identity, (3) Conceptualizing vaginal and sexual health, and (4) Building trust. Women found that vaginal dilator therapy during prehabilitation enabled a sense of control and readiness for upcoming sexual and vaginal health concerns. The early support was perceived as timely, acceptable, and empowering, regardless of women's initial motivation to engage. None of the women preferred to only receive the information after treatment, reflecting the value of proactive care.CONCLUSION: Integrating vaginal dilator therapy into prehabilitation may enhance preparedness, promote self-care, and reduce distress during pelvic radiotherapy. Further research is needed to confirm benefits and tailor support to individual needs.}, issn = {1462-3889} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kaninaaleksandra_2025, title = {Prenatal exposure to adverse life events and autism and autistic-like traits in children in the Norwegian Mother, Father and Child Cohort Study (MoBa)}, author = {Kanina, Aleksandra and Sjölander, Arvid and Martini, Miriam I. and Butwicka, Agnieszka and Larsson, Henrik and Hughes, Amanda M. and Radó, Márta K. and Taylor, Mark J. and Havdahl, Alexandra and Ask, Helga and Rosenqvist, Mina A.}, year = {2025}, journal = {JCPP Advances}, volume = {5}, number = {4}, doi = {10.1002/jcv2.70002}, url = {1949742}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {autism; delayed effects; mbrn; moba; prenatal exposure; sibling-comparison design}, abstract = {Background: Mothers' experience of adverse life events (ALEs, e.g., divorce, bereavement, injury) during pregnancy has been linked with neurodevelopmental conditions like autism, and related traits like social communication difficulties and repetitive behavior in children. However, both the cumulative association and the underlying mechanism are unclear, and these associations might be confounded by unmeasured genetic or other early environmental factors shared within families.Method: This longitudinal population-based cohort study included 114,247 children, born in Norway between 1999 and 2009, who participated in the Norwegian Mother, Father and Child Cohort Study. During week 30 of pregnancy, mothers of 51,940 children (of whom 12,597 were siblings) reported whether they had experienced ALEs. We estimated associations between mothers' cumulative exposure to and perception of ALE and their children's clinical diagnosis of autism, and maternal reports on their children's autistic traits at ages 3 and 8 years through the Social Communication Questionnaire (SCQ). Sibling comparisons were conducted to account for unmeasured familial confounding.Results: Each additional prenatal ALE was associated with increased adjusted hazard ratios [HR: 1.23, 95% CI: 1.16-1.30] of autism diagnosis, compared to unexposed children. Adjusting for unmeasured familial confounding in sibling comparisons, the association attenuated: HR = 0.53, 95% CI [0.31-0.90]. ALEs perceived as more painful were associated with a 12% elevated likelihood of autism diagnosis [95% CI: 7%-16%], but this association attenuated after sibling comparisons. SCQ scores in children exposed to cumulative prenatal ALE compared to unexposed children were higher at age 3 (beta-coefficient: 0.24 (95%CI [0.21-0.27])), but only slightly at age 8 (beta-coefficient: 0.07 [95% CI: 0.04-0.10]) with differences nullified in the sibling comparison analysis.Conclusion: The association between maternal prenatal exposure to cumulative ALEs and diagnosis of autism and autism-associated traits is likely due to unmeasured familial confounding rather than a direct causal relationship.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_barronaaron_2025, title = {Prenatal exposure to perfluoroalkyl substances predicts multimodal brain structural and functional outcomes in children aged 5 years : a birth cohort study}, author = {Barron, Aaron and Dickens, Alex M. and Tuulari, Jetro J. and Hyötyläinen, Tuulia and Kortesluoma, Susanna and Merisaari, Harri and Pulli, Elmo P. and Silver, Eero and Kumpulainen, Venla and Copeland, Anni and Saukko, Ekaterina and Lewis, John D. and Karlsson, Linnea and Oresic, Matej and Karlsson, Hasse}, year = {2025}, journal = {The Lancet Planetary Health}, volume = {9}, number = {9}, doi = {10.1016/j.lanplh.2025.101309}, url = {2005996}, language = {eng}, publisher = {Elsevier}, abstract = {BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are ubiquitous persistent organic pollutants associated with adverse health outcomes in humans. Although they are associated with autism spectrum disorder and behavioural outcomes, whether PFAS affect brain development is unclear. We aimed to characterise the relationship between maternal PFAS and brain structure and function in typically developing children.METHODS: This study was set within the FinnBrain Birth Cohort Study, a prospective observational study that enrolled mothers from three clinics in Turku, Finland, during their first trimester of pregnancy. Maternal serum samples at gestational week 24 were analysed for PFAS by mass spectrometry and, at age 5 years, children were assessed through structural, diffusion-weighted, and functional MRI. Whole-brain voxel-level and vertex-level maps of grey matter volume, white matter fractional anisotropy and mean diffusivity, and cortical thickness and surface area were combined to compute ten independent components. Data were analysed by correlation network, elastic net regression, and multivariate linear regression with multiple testing correction.FINDINGS: Pregnant mothers were enrolled into the birth cohort study between Dec 1, 2011, and April 30, 2015, and study visits at age 5 years took place between Oct 1, 2017, and March 31, 2020. This analysis involved 51 mother-child dyads for whom maternal PFAS concentrations and structural MRI data for the child were available. PFAS concentrations in maternal serum samples were mostly 0-1 ng/mL. Maternal perfluorononanoic acid (PFNA; R2=0·13, β=0·39 [95% CI 0·09-0·69], padj=0·024) and linear perfluorooctanoic acid (PFOA; 0·13, 0·36 [0·09-0·63], padj=0·022) linearly predicted a multimodal component dominated by corpus callosal integrity, whereas branched perfluorohexanesulphonic acid (PFHxS; R2=0·12, β=0·31, padj=0·036) and branched PFOA (R2=0·14, β=0·36, padj=0·016) predicted a component comprising mainly occipital cortex volume and surface area. Branched perfluorooctanesulphonic acid predicted hypothalamic microstructure (R2=0·10, β=0·29, p=0·026). PFNA, linear PFOA, and branched PFOA are associated with increased functional connectivity in the right precentral gyrus, whereas branched PFHxS predicts decreased connectivity in the intracalcerine cortices. Associations were not influenced by sex assigned at birth, but were related to PFAS chemical structure.INTERPRETATION: We show an association between prenatal PFAS exposure and brain developmental outcomes in children. These findings are pertinent given the ubiquitous circulation of PFAS in humans and the extreme environmental persistence of these substances. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_padulaamym_2025, title = {Prenatal Per- and Polyfluoroalkyl Substances in Relation to Antibody Titers and Infections in Childhood}, author = {Padula, Amy M. and Salihovic, Samira and Zazara, Dimitra E. and Diemert, Anke and Arck, Petra C.}, year = {2025}, journal = {Environmental Research}, volume = {270}, doi = {10.1016/j.envres.2025.120976}, url = {1933275}, language = {eng}, publisher = {Elsevier}, keywords = {pfas; childhood; immunity; infection; pregnancy; vaccine}, abstract = {BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are persistent and ubiquitous chemicals posing environmental and health risks. Impact on the human immune system is of particular concern, especially during fetal immune development. Alterations to fetal immune development can impact immunity later in life, e.g., the response to vaccines and pathogens. OBJECTIVES: This study investigated the association between PFAS concentrations in healthy pregnant women from Hamburg, Germany, and antibody levels to routine vaccines in childhood and occurrence of childhood infections.METHODS: Mid-pregnancy serum samples from 152 mothers-child pairs were analyzed for 18 PFAS compounds, and antibody levels to measles, mumps, rubella, diphtheria, and tetanus were assessed at age 5. Maternal questionnaires provided data on childhood infections each year at age 1-5. Linear and Poisson regression models were adjusted for maternal age, education, parity, and breastfeeding duration. Weighted quantile sum (WQS) regression was used to assess the PFAS mixture.RESULTS: Higher PFAS concentrations were associated with lower antibody titers at age 5 years, particularly for mumps, tetanus, diphtheria, and rubella. Several PFAS were also linked to increased childhood infections, especially respiratory infections, during ages 3 and 4 years. WQS regression revealed a negative association between combined PFAS and tetanus titers.CONCLUSIONS: Maternal PFAS concentrations during pregnancy are inversely associated with antibody levels in children and positively associated with increased childhood infections, notably respiratory infections. These findings underscore the importance of understanding environmental exposures' impact on immune responses and call for continued monitoring of PFAS in both the environment and human populations to mitigate health risks.}, issn = {0013-9351} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wallerstedtsusannam_2025, title = {Preparing medical students to incorporate scientific evidence into patient care : A cross-sectional study}, author = {Wallerstedt, Susanna M. and Garwicz, Martin and Henriksson, Pontus and Mossberg, Karin and Naumburg, Estelle and Wahlberg, Jeanette and Möller, Riitta}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {4}, doi = {10.1371/journal.pone.0321211}, url = {1950239}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {OBJECTIVE: To explore teaching- and assessment-related factors that predict medical students' perceived attainment of sufficient skills to incorporate scientific evidence into patient care.METHODS: An anonymous questionnaire was distributed to final-semester students in six medical programs in Sweden. The students were asked to rate statements concerning the extent to which 11 national degree outcomes related to the scientific basis of medicine (scholarly degree outcomes) had been adequately assessed during the program; their perceived preparedness for evidence-based patient care; and training during the program regarding the components of a systematic review/health technology assessment (HTA).RESULTS: In total, 433 students (median age: 25 years [interquartile range: 24‒28], 59% female) participated in the study (response rate: 68%). A multivariate analysis indicated that experienced adequate assessment on a single scholarly degree outcome (i.e., "Demonstrate knowledge of the scientific foundation of medicine and insight into current research as well as knowledge of the link between science and proven experience") predicted the students' perception of having developed sufficient skills in incorporating scientific evidence into patient care (odds ratio: 6.17 [95% confidence interval: 3.10; 12.3]). The educational content predictors of this perception included the teaching of HTA (11.3 [1.44; 89.5]) and training regarding two components of a systematic review/HTA: appraising scientific articles using checklists (2.46 [1.23; 4.90]) and assessing organizational aspects related to the introduction/withdrawal of a health technology (2.65 [1.05; 6.67]). The presence of hands-on, credit-bearing, evidence-based medicine (EBM)-related learning activities during clinical courses was also predictive (4.68 [1.69; 13.0]).CONCLUSIONS: This study highlights important educational activities that prepare medical students to incorporate scientific evidence into patient care: (i) adequate assessment of key content regarding scholarly outcomes, including the scientific foundation of medicine; (ii) learning activities about HTA and the systematic review process; and (iii) hands-on application of EBM-related learning activities integrated into clinical courses.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_larssonhenrik_2025_1, title = {Preregistration of high-quality protocols in pharmacoepidemiology research}, author = {Larsson, Henrik and Chang, Zhang and Man, Kenneth K. C.}, year = {2025}, journal = {JCPP Advances}, volume = {5}, number = {4}, doi = {10.1002/jcv2.70020}, url = {1970011}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {child and adolescent mental health; open science; pharmacoepidemiology; preregistration; registered reports; reproducible research}, abstract = {Pharmacoepidemiology studies are an important complement to Randomized Clinical trials, but such studies face several challenges, such as confounding and selective reporting. How to best address confounding has been discussed in detail for many years. More recent discussions have highlighted the value of pharmacoepidemiology studies based on pre-registered protocols. This is an important step to address problems related to selective reporting and to enhance transparency and reproducibility. In this editorial perspective, we discuss the value of pre-registered protocols in pharmacoepidemiology.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_primusfranziska_2025, title = {Present Futures in Global Education Governance : A Critical Discourse Analysis of UNESCO's Futures of Education Initiative}, author = {Primus, Franziska}, year = {2025}, url = {1943207}, language = {eng}, publisher = {Örebro University}, keywords = {present futures; futures of education; unesco; anticipatory global governance; global education policy; discourse historical approach; sociology of expectations; sociological fictionalism}, abstract = {This thesis examines the role of present futures in global education policy discourse by analysing how they shape and are used to legitimise programmatic ideas for education. The thesis acknowledges present futures as action-guiding factors and arguments inspired by the sociology of expectations and sociological fictionalism.UNESCO's initiative Futures of Education: Learning to Become serves as the empirical entry point into the global education governing arena. This study comprises material published from the initiative's launch in 2019 up to the initiative's final report, published in 2021. The report was compiled by the International Commission on the Futures of Education, which UNESCO invited to revise educational futures in exchange with experts and the public. Moreover, the Faure report (1972) and the Delors report (1996), which are similar flagship reports commissioned by UNESCO, are considered for an appropriate contextualisation of the subject matter. The analysis draws on the discourse historical approach (DHA) and therefore integrates thoroughly sociopolitical and historical context for the analysis.This thesis shows how futures were imagined and portrayed as elusive and disruptive in the Futures of Education initiative and how that meant that education needed to be flexible, adaptable, and plural. However, to understand the present futures and programmatic ideas this thesis unearthed, it is essential to consider the peculiarity of the global education governing arena and UNESCO's history of struggle to stay relevant. After all, the initiative also functioned as an opportunity or strategy to (re)produce and legitimise the role of UNESCO as a humanistic actor and brand in the global education governing arena while maintaining to be relevant to diverse stakeholders and ideologies.}, file = {https://oru.diva-portal.org/smash/get/diva2:1943207/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hurtsnannastene_2025, title = {Preservation of One Anterior and One Posterior Internal Iliac Artery Branch in a Case of Bilateral Common and Internal Iliac Arterial Aneurysms}, author = {Hurtsén, Anna Stene and Pirouzram, Artai and Hörer, Tal M.}, year = {2025}, journal = {EJVES Vascular Forum (EJVES VF)}, volume = {64}, pages = {71--74}, doi = {10.1016/j.ejvsvf.2025.05.009}, url = {1989255}, language = {eng}, publisher = {Elsevier}, keywords = {internal iliac aneurysm; common iliac aneurysm; iliac branch device; pelvic circulation}, abstract = {Introduction: Endovascular treatment of iliac aneurysms with sparing of the internal iliac arterial circulation is feasible with iliac branch devices. However, insufficient distal seal with the endovascular devices on the market can be challenging. In this case, the anatomy was complex due to the extent of the aneurysms, and the available technical options were limited.Report: A 65 year old man with aneurysms in the left common iliac (43 mm) and bilateral internal iliac arteries (right 41 mm; left 49 mm) was treated with an aortobi-iliac stent graft and bilateral iliac branch devices with extensions to opposing anterior (right) and posterior (left) branches of the internal iliac artery through staged interventions. At six weeks of follow up all treated aneurysms had decreased or were stable in size. Clinical signs of right sided gluteal claudication were evident at six weeks of follow up but no symptoms remained 20 weeks post-operatively.Discussion: The presented case illustrates a technique to preserve pelvic circulation in a case of bilateral common and internal iliac arterial aneurysms. Extensions of the internal iliac limb of the iliac branch device, into the opposing anterior and posterior divisions of the internal iliac artery, may offer a strategy to reduce pelvic ischaemia in scenarios where the anatomy limits the use of standard iliac branch devices.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wennbergpr_2025, title = {Pressure Properties of a New Positive Expiratory Pressure Device-OpenUp Flow a Three-in-One Solution}, author = {Wennberg, Pär and Sundberg, Bengt and Westerdahl, Elisabeth}, year = {2025}, journal = {Clinical Respiratory Journal}, volume = {19}, number = {5}, doi = {10.1111/crj.70084}, url = {1958440}, language = {eng}, publisher = {Blackwell Publishing}, keywords = {breathing exercises; chronic obstructive; pulmonary disease; respiratory therapy}, abstract = {INTRODUCTION: A new flow-regulated PEP device has been evaluated regarding functionality and pressure properties.METHODS: The three different resistance levels were assessed and evaluated at standardized flow rates of 10 and 18 L/min; Kruskal-Wallis test was used to analyse the differences in generated pressure between the different resistance levels.RESULTS: A range of 3-31 cmH2O was generated with airflows of 10 and 18 L/min. There was a significant difference in pressure among different resistance levels at both flow rates.CONCLUSION: Overall, there was a significant difference in pressure among different resistance levels at both flow rates, showing that the high resistance significantly increased pressure compared with low resistance. This new device is performing comparable with other resistors available in the market.}, issn = {1752-6981} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_schrderdaniel_2025_1, title = {Prevalence and epidemiology of Mycoplasma genitalium and the absence of macrolide resistance in M. genitalium among pregnant women attending antenatal care in Zambia}, author = {Schröder, Daniel and Sorano, Sumire and Shipitsyna, Elena and Chaponda, Enesia Banda and Golparian, Daniel and Chikwanda, Ephraim and Mwewa, Vivian and Mulenga, Joyce M. and Chaponda, Mike and Smith, Chris and Mitsuaki, Matsui and Mirandola, Massimo and Blondeel, Karel and Toskin, Igor and Chico, R. Matthew and Unemo, Magnus}, year = {2025}, journal = {Frontiers in Public Health}, volume = {13}, doi = {10.3389/fpubh.2025.1576376}, url = {1962046}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {mycoplasma genitalium; pregnancy; prevalence; antimicrobial resistance; azithromycin; macrolide resistance; zambia; antenatal care}, abstract = {Introduction: Mycoplasma genitalium (MG) is a sexually transmitted bacterium of public health importance, associated with genitourinary disorders, and adverse reproductive and perinatal outcomes. Global data on MG prevalence and antimicrobial resistance (AMR) are primarily available from high-income countries, whereas there is a dearth of information from resource-constrained settings including sub-Saharan Africa. Furthermore, international data on MG rates and AMR in the antenatal population are scarce. Understanding MG prevalence and AMR patterns is crucial for developing effective public health strategies and treatment guidelines. The aim of this study was to investigate the prevalence and epidemiology of MG and the presence of macrolide resistance-associated mutations (MRAMs) among pregnant women attending antenatal care facilities in Zambia.Methods: A cross-sectional study was conducted at four antenatal care facilities in Nchelenge, Zambia, among 1,021 pregnant women. Vaginal swabs were collected and tested using the Aptima Mycoplasma genitalium assay, Aptima Combo 2 assay and Aptima Trichomonas vaginalis assay on the Panther System (Hologic). MG-positive samples were further analyzed for MRAMs using the ResistancePlus (TM) MG assay (SpeeDx).Results: The prevalence of MG was 12.6% (127 of 1,005 valid samples) among the pregnant women. Only 12 MG-positive women (9.4%) had symptoms of a genitourinary infection, which was similar to the frequency of genitourinary symptoms among MG-negative women (6.1%). The rates of Chlamydia trachomatis, Neisseria gonorrhoeae, T. vaginalis, and HIV seropositivity were 7.4, 8.3, 23.0, and 8.6%, respectively. MG infection was significantly associated with the presence of all other tested sexually transmitted infections and HIV seropositivity: the detection rates of C. trachomatis, N. gonorrhoeae, T. vaginalis, and HIV seropositivity were significantly higher in MG-positive than in MG-negative women (15.1% vs. 6.2, 15.0% vs. 7.5, 32.3% vs. 22.0, and 14.3% vs. 7.5%, respectively). The ResistancePlus (TM) MG assay detected MG in 66.1% (84/127) of samples positive by the Aptima M. genitalium assay, however, no MRAMs were detected in the 23S rRNA gene for any of these 84 samples.Discussion: This study emphasizes the high prevalence of MG among pregnant women in Zambia, but also lack of MRAMs in MG. These findings suggest that azithromycin remains an efficacious treatment option for MG in this population. Nevertheless, continuous surveillance and judicious macrolide use to maintain treatment efficacy are imperative. Further research and sustained monitoring of MG are essential to inform public health strategies and clinical guidelines in Zambia and similar settings worldwide.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_liuxingrong_2025, title = {Prevalence and prognosis of patients with breast cancer eligible for adjuvant abemaciclib or ribociclib : a nationwide population-based study}, author = {Liu, Xingrong and Binicy, Behnaz and Acs, Balazs and Eriksson Bergman, Louise and Loibl, Sibylle and Gnant, Michael and Untch, Michael and Valachis, Antonis and Bergh, Jonas and Hartman, Johan and Foukakis, Theodoros and Matikas, Alexios}, year = {2025}, journal = {The Lancet Regional Health: Europe}, volume = {59}, doi = {10.1016/j.lanepe.2025.101471}, url = {2006254}, language = {eng}, publisher = {Elsevier}, keywords = {abemaciclib; adjuvant; breast cancer; cdk4/6 inhibitors; natalee; ribociclib; monarche}, abstract = {BACKGROUND: Nationwide studies on the prevalence, characteristics and long-term prognosis of patients with early breast cancer and a potential indication for adjuvant CDK4/6 inhibitors are lacking.METHODS: We leveraged a prospectively collected nationwide cohort of all patients treated for breast cancer in Sweden in 2007-2023 and identified patients fulfilling the monarchE and/or the NATALEE eligibility criteria, to estimate the proportion of eligible patients for adjuvant CDK4/6 inhibitors and their outcomes. Overall survival (OS) was the primary endpoint of interest. In addition, we compared distant relapse-free survival and OS of a patient subset treated in the Stockholm-Gotland region in 2012-2020 to patients enrolled in the phase 3 PANTHER trial (NCT00798070) in 2007-2011, before and after alignment of key inclusion criteria.FINDINGS: Of 52,602 patients with ER-positive, HER2-negative breast cancer, 9553 (18.2%) fulfilled both the monarchE and the NATALEE criteria, 9800 (18.6%) fulfilled the NATALEE criteria only and 745 patients (1.4%) fulfilled the monarchE criteria only. Median follow-up was 6.87 years. Ten-year OS rates were 65.7% (95% CI 65.3%-67.0%) for monarchE-eligible and 70.2% (95% CI 69.3%-71.1%) for NATALEE-eligible patients, and 84.0% (95% CI 83.4%-84.6%) for non-eligible, 75.5% (74.4$-76.7%) for NATALEE-only eligible and 64.3% (95% CI 62.9%-65.7%) for concordant eligible patients for both studies (p < 0.0001). Before alignment of inclusion criteria, patients treated within the PANTHER trial had improved outcomes compared to those treated in clinical routine. However, the differences in outcomes disappeared after alignment.INTERPRETATION: These results inform on the prevalence and prognosis of candidates for adjuvant CDK4/6 inhibitors at a nationwide level. FUNDING: Cancerfonden, Bröstcancerförbundet, Radiumhemmets Forskningsfonder, Amgen, Roche, Sanofi-Aventis.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_madsenmalenegalle_2025, title = {Prevalence and Temporal Trends of Attention Deficit Hyperactivity Disorder Medication Fills During Pregnancy and Breastfeeding in Denmark}, author = {Madsen, Malene Galle and Zhu, Jin Liang and Munk-Olsen, Trine and Wimberley, Theresa and Larsson, Henrik and Rommel, Anna-Sophie and Liu, Xiaoqin and Kjeldsen, Mette-Marie Zacher and Kittel-Schneider, Sarah and Bergink, Veerle and Madsen, Kathrine Bang}, year = {2025}, journal = {Pediatric Drugs}, volume = {27}, number = {2}, pages = {233--246}, doi = {10.1007/s40272-024-00671-5}, url = {1927020}, language = {eng}, publisher = {Adis International Ltd.}, abstract = {BACKGROUND AND OBJECTIVES: Females of reproductive age are increasingly using attention deficit hyperactivity disorder (ADHD) medication, but its use during pregnancy and breastfeeding is largely unknown. The aim of this study is to examine the prevalence of ADHD medication fills during pregnancy and breastfeeding, including characteristics of these females and cohort differences over time.METHODS: We conducted a descriptive study using Danish nationwide registers. Within cohorts of pregnant and breastfeeding females, we calculated the prevalence of ADHD medication (methylphenidate, amphetamine, dexamfetamine, lisdexamfetamine, modafinil, atomoxetine, clonidine and guanfacine) fills and described sociodemographic and clinical characteristics across groups with fills, no fills and previous fills. Cohort differences in ADHD medication fills during pregnancy for 2005-2010, 2011-2016 and 2017-2022 were examined.RESULTS: In this cohort of 1,077,279 pregnancies, ADHD medication fills increased from 0.08 to 7.71 per 1000 individuals between 2005 and 2022. Among 446,485 breastfeeding females, fills increased from 0.55 to 3.67 per 1000 individuals from 2012 to 2022. Compared with the group with no fills, females filling ADHD medication during pregnancy and breastfeeding were younger, had lower levels of education, were more often smoking during pregnancy, utilised more psychiatric healthcare and had concurrent fills of other psychotropic medication. Cohort differences over time revealed that females filling ADHD medication during pregnancy in 2017-2022 were older, had higher levels of education, smoked less during pregnancy, had fewer psychiatric contacts and were less likely to fill other psychotropic medications compared with females in the earlier cohorts.CONCLUSIONS: Results showed an increasing prevalence of ADHD medication fills during pregnancy and breastfeeding in Denmark over time, surpassing the increase observed generally in females of reproductive age filling ADHD medication. Results revealed a difference in characteristics of females filling ADHD medication during pregnancy over time, suggesting a shift in pregnancy treatment patterns.}, issn = {1174-5878} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jansanders_2025_1, title = {Prevalence of dumping and hypoglycaemia symptoms after bariatric surgery : A questionnaire-based cross-sectional study}, author = {Jans, Anders and Rask, Eva and Ottosson, Johan and Szabo, Eva and Stenberg, Erik}, year = {2025}, journal = {Clinical Obesity}, volume = {15}, number = {1}, doi = {10.1111/cob.12709}, url = {1905159}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {bariatric surgery; dumping; hypoglycaemia; prevalence; questionnaire}, abstract = {Dumping and post-bariatric hypoglycaemia (PBH) are side effects that occur after bariatric surgery. The aim of this study was to estimate the prevalence of dumping and PBH symptoms before Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) at 6 months, 1 year, 2 years and 5 years after surgery in a Swedish population. A cross-sectional single-centre study was performed at Lindesberg Hospital, Region Örebro County, Sweden, between 2020 and 2023. The Swedish version of the Dumping Severity Scale (DSS-Swe) questionnaire, which includes eight items regarding dumping symptoms and six items regarding hypoglycaemia symptoms, was used. A total of 742 DSS-Swe questionnaires were included. The average age at surgery was 42.0 years (standard deviation [SD] = 11.9), and the average body mass index was 41.8 kg/m2 (SD = 5.9). The surgical methods consisted of RYGB (66.3%) and SG (33.7%). The proportion of RYGB patients with highly suspected dumping increased from 4.9% before surgery to 26.3% (adjusted odds ratio [OR] = 7.35, 95% confidence interval [CI] = 3.08-17.52) at the 5-year follow-up. PBH symptoms increased from 1.4% before surgery to 19.3% at the 5-year follow-up (adjusted OR = 17.88, 95% CI = 4.07-78.54). For SG patients, no significant increase in dumping or PBH symptoms was observed. In patients with persistent type 2 diabetes (T2D), there were no cases of highly suspected hypoglycaemia following RYGB or SG. Symptoms of dumping and PBH were common after RYGB, while no clear increase was observed after SG. Persistent T2D seems to be a protective factor against PBH symptoms.}, issn = {1758-8103} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parkerwilliamae_2025, title = {Prevalence of microspirometry-detected chronic obstructive pulmonary disease in two European cohorts of patients hospitalised for acute myocardial infarction : a cross-sectional study}, author = {Parker, William A. E. and Sundh, Josefin and Oldgren, Jonas and Andell, Pontus and Reitan, Christian and Jernberg, Tomas and Hofmann, Robin and Mohammad, Moman A. and Erlinge, David and Akerblom, Axel and Lawesson, Sofia Sederstam and Konstantinidis, Kyriakos V. and Lindbäck, Johan and Janson, Christer and Björkenheim, Anna and Elamin, Nadir and McMellon, Hannah and Moyle, Bethany and Patel, Mehul and El-Khoury, Jad and Surujbally, Raulin and Storey, Robert F. and James, Stefan K.}, year = {2025}, journal = {BMJ Open}, volume = {15}, number = {5}, doi = {10.1136/bmjopen-2024-097851}, url = {1957634}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {myocardial infarction; pulmonary disease; chronic obstructive; respiratory function test}, abstract = {OBJECTIVES: To establish the prevalence of clinically significant chronic obstructive pulmonary disease (COPD) and relevant characteristics in individuals with a significant smoking history who are hospitalised for acute myocardial infarction (MI).DESIGN: Cross-sectional study.SETTING: Hospital inpatients at 8 European centres (7 in Sweden, 1 in the UK). PARTICIPANTS: 518 men or women (302 in Sweden, 216 in the UK) hospitalised for acute MI, aged 40 years or older, with a smoking history of at least 10 pack-years.PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was prevalence of detected significant COPD (Global Initiative for Chronic Obstructive Lung Disease stages 2-4), defined as a ratio of forced expiratory volume in 1 and 6 s (FEV1/FEV6) <0.7 and FEV1 <80% of the predicted value, measured using microspirometry. Secondary outcome measures were prior diagnosis of COPD, prescription of inhaled corticosteroids (ICS), symptom burden (COPD Assessment Test (CAT)) and blood eosinophil count.RESULTS: The prevalence of significant COPD was 91/518 (18% (95% CI 14 to 21)) with no difference between the countries. Of those with detected significant COPD, 69 (76%) had no previous COPD diagnosis. A CAT score >10 was found in 65%, and a blood eosinophil count of ≥100/mm3 and ≥300/mm3 was found in 76% and 20%, respectively. Inhaled corticosteroids were used by 15% of the patients.CONCLUSIONS: In a cohort of patients hospitalised for acute MI in Sweden and the UK, one in five patients with a history of smoking was found to have significant COPD based on microspirometry. Symptom burden was high and treatment rates with ICS low. Among those diagnosed with COPD, three out of four had not been previously diagnosed with COPD.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sundhjosefin_2025_3, title = {Prevalence of Myocardial Infarction With Obstructive and Non-Obstructive Coronary Arteries in a Middle-Aged Population With Chronic Airflow Limitation : A Cross-Sectional Study}, author = {Sundh, Josefin and Ekström, Magnus and Blomberg, Anders and Lindberg, Eva and Malinovschi, Andrei and Olin, Anna-Carin and Sköld, C. Magnus and Torén, Kjell and Wollmer, Per and Östgren, Carl Johan and Jernberg, Tomas}, year = {2025}, journal = {The International Journal of Chronic Obstructive Pulmonary Disease}, volume = {20}, pages = {303--312}, doi = {10.2147/COPD.S477986}, url = {1938687}, language = {eng}, publisher = {Dove Medical Press}, keywords = {copd; coronary atherosclerosis; sex; smoking}, abstract = {PURPOSE: Myocardial infarctions (MIs) can occur in underlying obstructive coronary artery disease (MI-CAD) or in non-obstructive coronary arteries (MINOCA). The primary objectives of the study were to investigate the prevalence of MI-CAD and MINOCA in people with CAL, and to explore if CAL is an independent risk factor for MI-CAD and MINOCA. Secondary objectives were to explore these research questions stratified by sex and by smoking history.PATIENTS AND METHODS: Cross-sectional analysis of the population-based Swedish CArdioPulmonary bioImage Study (SCAPIS) of people aged 50-64 years. CAL was defined as a post-bronchodilator ratio of forced expiratory volume in one second and forced vital capacity below 0.70. MI-CAD was defined as a self-reported MI with coronary computed tomography angiography findings of previous revascularization or at least one significant coronary stenosis (>50%), and MINOCA as self-reported MI with no previous revascularization and no significant coronary stenosis.RESULTS: In total, 1735 (8.3%) of 20,882 included participants had CAL. MI-CAD was more common than MINOCA both in people with (2.8 vs 0.6%) and without CAL (1.2 vs 0.3%). Compared with those without CAL, people with CAL had an almost doubled independent risk of both MI-CAD ([adjusted OR] 1.72; [95% CI] 1.22-2.42) and MINOCA (1.99; 1.02-3.86). In men, CAL was associated with increased risk of MINOCA (2.63; 1.23-5.64), and in women with increased risk for MI-CAD (3.43; 1.68-1.26).CONCLUSION: Middle-aged people with CAL have an almost doubled risk of both MI-CAD and MINOCA, compared with people without CAL. In contrast to people without CAL, the risk of MINOCA is increased in men and the risk of MI-CAD is increased in women. In a clinical context, both MI types should be considered in CAL.}, issn = {1176-9106} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nordenskjldannam_2025_2, title = {Prevalence of psychiatric comorbidity and negative psychosocial factotrrs in patients with myocardial infarction with and without obstructive coronary arteries and its association with prognosis}, author = {Nordenskjöld, Anna M. and Wirén, Anders and Schef, K. Welen and Hakannson, F. and Tornvall, P. and Lindahl, B.}, year = {2025}, journal = {European Heart Journal}, volume = {46}, number = {Suppl. 1}, doi = {10.1093/eurheartj/ehaf784.1982}, url = {2037881}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background and purpose: The impact of psychiatric disorders and psychosocial factors in patients experiencing myocardial infarction with non-obstructive coronary arteries (MINOCA) is unknown. We investigated the prevalence of psychiatric diagnoses, the use of medications affecting the nervous system, and negative psychosocial factors in patients experiencing MINOCA and MI with coronary artery disease (MI-CAD), and assessed their association with prognosis.Method: Nationwide descriptive cohort study based on data collected from the SWEDEHEART registry, census data from Statistics Sweden and three mandatory Swedish population-based national registries: Prescribed Drug Register, the Patient Register, and the Cause-of-death Register.Results: A total of 8,367 MINOCA and 109,059 MI-CAD patients were included. In the six months prior to MI, MINOCA patients showed a significantly higher rate of psychiatric diagnoses (4.3% vs 2.6%, p<0.001) and a greater rate of dispensed medication acting on the nervous system (32.1% vs 22.9%, p<0.001) compared to MI-CAD. At the time of MI, MINOCA patients were significantly more likely to be divorced (21.1% vs 19.7%, p<0.001), widowed (6.8% vs 4.9%, p<0.001), or on sick leave (4.4% vs 3.2%, p<0.001) than MI-CAD. Over the course of a median follow-up of 5.5 years, 31.8% of MINOCA and 33.2% of MI-CAD patients experienced a major adverse cardiovascular event (MACE) (p<0.001). In multivariable analyses adjusted for traditional risk factors, psychiatric diagnosis or a dispensed drug acting on the nervous system were independently associated with MACE in both MINOCA (HR 1.30; 95% CI 1.17–1.38) and MI-CAD (HR 1.33; 95% CI 1.30–1.36).Conclusion: The prevalence of psychiatric diagnoses, dispensed drugs acting on the nervous system, and negative psychosocial factors was greater in patients with MINOCA than with MI-CAD. The association of these factors with adverse outcomes in both MINOCA and MI-CAD may indicate a common underlying mechanism beyond traditional cardiovascular risk factors.}, issn = {0195-668X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_akhtarzubair_2025_1, title = {Prevention of Cardiovascular Diseases with Standard-Dose Quadrivalent Influenza Vaccine in People Aged ≥50 Years in Australia During the 2017 A/H3N2 Epidemic}, author = {Akhtar, Zubair and Moa, Aye M. and Tan, Timothy C. and Fröbert, Ole and Menzies, Robert and MacIntyre, C. Raina}, year = {2025}, journal = {Vaccines}, volume = {13}, number = {4}, doi = {10.3390/vaccines13040407}, url = {1957050}, language = {eng}, publisher = {MDPI}, keywords = {cardiovascular disease (cvd); hospitalization; influenza vaccination; propensity score matching; vaccine effectiveness}, abstract = {Background: In Australia, 2017 was a severe A/H3N2 season and, therefore, we estimated the effectiveness of standard-dose quadrivalent influenza vaccine in preventing hospitalization for cardiovascular disease (CVD) among New South Wales (NSW) residents aged ≥50 years.Methods: We conducted a nested, matched case-control study within the 45 and Up study, linking data from the Australian Immunization Register, NSW Admitted Patient Data Collection and Pharmaceutical Benefits Schedule. Cases were individuals hospitalized for CVD and controls were those who were hospitalized for gastrointestinal diseases. The two groups were balanced using 1:1 propensity score matching based on age group (50-64, 65-74, 75-84, and ≥85 years) and sex. After adjusting for confounders (smoking, body mass index and income), we calculated the adjusted odds ratio (aOR) for vaccination during the season using multivariable logistic regression. E-values were estimated to assess residual confounding. Vaccine effectiveness (VE) was calculated as (1 - aOR) × 100.Results: There were 10,445 (4452 cases and 5993 controls) study participants. After matching, 8904 (85.2%) were retained with a mean age of 76.4 ± 10.4 years and 58.3% men. Following adjustment for confounders, the aOR of averting a CVD hospitalization was 0.15 (95% CI: 0.13 to 0.17; p < 0.001). The estimated VE against CVD hospitalization was 85% (95% CI: 83 to 87). We found an E-value of 12.82, indicating strong evidence of minimal residual confounding.Conclusions: In the severe 2017 influenza A/H3N2 season in Australia, we observed a high VE in preventing cardiovascular hospitalization despite a low VE against influenza infection prevention. Improving vaccine uptake may reduce cardiovascular burden.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lennartssonotto_2025, title = {Priming Short Children with Sex Steroids prior to Growth Hormone Testing Decreases the Frequency of Divergent Results}, author = {Lennartsson, Otto and Nilsson, Ola and Lodefalk, Maria}, year = {2025}, journal = {Hormone Research in Paediatrics}, doi = {10.1159/000546884}, url = {1986548}, language = {eng}, publisher = {S. Karger}, keywords = {arginine-insulin tolerance test; children; growth hormone deficiency; sex steroid priming; short stature}, abstract = {Introduction: Diagnosing growth hormone (GH) deficiency (GHD) is challenging due to the low specificity of diagnostic tests, particularly in children during the prepubertal and early pubertal stages. Although sex steroid priming increases stimulated GH peak levels, its impact on spontaneous nocturnal GH values has not yet been reported. Priming may reduce discrepancies between spontaneous and stimulated GH testing, potentially improving diagnostic accuracy. We aimed to assess the impact of priming on combined spontaneous and stimulated GH testing and the occurence of divergent test results, as well as to evaluate short-term adverse events associated with priming.Methods: This was a retrospective chart review of all 132 short children who underwent a nocturnal spontaneous GH secretion test followed by an arginine-insulin stimulation test over 30 years at the Department of Pediatrics, & Ouml;rebro University Hospital, Sweden.Results: Among the 132 children tested, 25 (19%) received priming prior to GH testing. Compared with nonprimed children, primed children presented higher peak and mean spontaneous GH values (14.2 mu g/L [0.6-22.5] vs. 10.8 mu g/L [0.2-27.0], p = 0.042 and 3.0 mu g/L [0.3-6.9] vs. 2.3 mu g/L [0.1-6.9], p = 0.007, respectively). Divergent results between the two GH tests were less common in primed children (4%) than in nonprimed children (23%, p = 0.027). Mild adverse events occured in three (12%) of the primed children.Conclusion: Sex steroid priming prior to GH testing is well tolerated, enhances spontaneous nocturnal GH secretion, and reduces the frequency of divergent results between spontaneous and stimulated values. We recommend incorporating priming when evaluating children in prepuberty or early puberty for suspected GHD.}, issn = {1663-2818} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kleykodenis_2025, title = {Principled neuromorphic reservoir computing}, author = {Kleyko, Denis and Kymn, Christopher J. and Thomas, Anthony and Olshausen, Bruno A. and Sommer, Friedrich T. and Frady, E. Paxon}, year = {2025}, journal = {Nature Communications}, volume = {16}, number = {1}, doi = {10.1038/s41467-025-55832-y}, url = {1927537}, language = {eng}, publisher = {Springer Nature}, abstract = {Reservoir computing advances the intriguing idea that a nonlinear recurrent neural circuit-the reservoir-can encode spatio-temporal input signals to enable efficient ways to perform tasks like classification or regression. However, recently the idea of a monolithic reservoir network that simultaneously buffers input signals and expands them into nonlinear features has been challenged. A representation scheme in which memory buffer and expansion into higher-order polynomial features can be configured separately has been shown to significantly outperform traditional reservoir computing in prediction of multivariate time-series. Here we propose a configurable neuromorphic representation scheme that provides competitive performance on prediction, but with significantly better scaling properties than directly materializing higher-order features as in prior work. Our approach combines the use of randomized representations from traditional reservoir computing with mathematical principles for approximating polynomial kernels via such representations. While the memory buffer can be realized with standard reservoir networks, computing higher-order features requires networks of 'Sigma-Pi' neurons, i.e., neurons that enable both summation as well as multiplication of inputs. Finally, we provide an implementation of the memory buffer and Sigma-Pi networks on Loihi 2, an existing neuromorphic hardware platform.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_strittmatterannamaria_2025, title = {Prioritization of the Sustainable Development Goals in the sustainability transition process of sport organizations : national strategies and sport managers’ perspectives}, author = {Strittmatter, Anna-Maria and Horbel, Chris and Traberg, Josephine and Strömberg, Julius Z. and Bodemar, Annika and Grønkjær, Allan B. and Hanstad, Dag Vidar}, year = {2025}, journal = {German Journal of Exercise and Sport Research}, volume = {55}, pages = {94--103}, doi = {10.1007/s12662-024-00985-z}, url = {1911849}, language = {eng}, publisher = {Springer}, keywords = {sustainable development; united nations agenda 2030; sport management; transition}, abstract = {This study explores the relevance, and applicability, of the Sustainable Development Goals (SDGs) in relation to Norwegian sport organizations’ sustainability transition. The following research questions guided the study: (1) How do National Sport Governing Bodies (NGBs) strategically address and prioritize SDGs and why? (2) How does the strategic prioritization of SDGs align with sport managers’ perspectives? (3) What does their prioritization of SDGs imply about the progress of sustainability transition within the Norwegian sports sector? The qualitative study is based on three interviews with directors in NGBs, document analysis of 11 strategy documents by six NGBs’ and essays produced by 82 sport managers representing the respective NGBs. Data analysis was informed by neo-institutional theory and the waves of sustainability transition framework. In our sample, spanning a diverse range of sports, we observed that 10 different SDGs are seen as relevant for NGBs from a strategy perspective, while sport managers prioritized eight. There is a strong alignment between national strategies and sport managers’ perspectives which is explainable through coercive, mimetic and normative pressures within the organizational field of sports. This further demonstrates that SDG prioritization is linked to the sport political context. While the alignment of prioritization from different perspectives provides a solid foundation for advancing sustainability work, the missing link between the SDGs and organizational goals with concrete suggestions for measures witnesses that Norwegian sport organizations are still in the infancy of sustainable transition.}, issn = {2509-3142} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_umairmuhammad_2025_2, title = {Privacy-preserving dementia classification from EEG via hybrid-fusion EEGNetv4 and federated learning}, author = {Umair, Muhammad and Khan, Muhammad Shahbaz and Hanif, Muhammad and Ghaban, Wad and Nafea, Ibtehal and Qasem, Sultan Noman and Saeed, Faisal}, year = {2025}, journal = {Frontiers in Computational Neuroscience}, volume = {19}, doi = {10.3389/fncom.2025.1617883}, url = {1995345}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {eegnet; fedavg; deep learning; dementia; federated learning; hybrid-fusion; neurobehavior analysis; smart healthcare}, abstract = {As global life expectancy rises, a growing proportion of the population is affected by dementia, particularly Alzheimer's disease (AD) and Frontotemporal dementia (FTD). Electroencephalography (EEG) based diagnosis presents a non-invasive, cost effective alternative for early detection, yet existing methods are challenged by data scarcity, inter-subject variability, and privacy concerns. This study proposes lightweight and privacy-preserving EEG classification framework combining deep learning and Federated Learning (FL). Five convolutional neural networks (EEGNetv1, EEGNetv4, EEGITNet, EEGInception, EEGInceptionERP) have been evaluated on resting-state EEG dataset comprising 88 subjects. EEG signals are preprocessed using band-pass (1-45 Hz) and notch filtering, followed by exponential standardization and 4-second windowing. EEGNetv4 outperformed among other EEG tailored models, and upon utilizing the hybrid fusion techniques it achieves 97.1% accuracy using only 1,609 parameters and less than 1 MB of memory, demonstrating high efficiency. Moreover, FL using FedAvg is implemented across five stratified clients, achieving 96.9% accuracy on the hybrid fused EEGNetV4 model while preserving data privacy. This work establishes a scalable, resource-efficient, and privacy-compliant framework for EEG-based dementia diagnosis, suitable for deployment in real-world clinical and edge-device settings.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_monsenjulius_2025, title = {Probabilistic Answer Set Programming Driven Ranking of Dynamic Space-Time Belief Models}, author = {Monsen, Julius and Suchan, Jakob and Bhatt, Mehul}, year = {2025}, volume = {16144}, pages = {156--175}, doi = {10.1007/978-3-032-08887-1_10}, url = {2024226}, language = {eng}, publisher = {Springer}, keywords = {probabilistic answer set programming; preferential ranking; visual intelligence; deep semantics; cognitive vision}, abstract = {A key challenge in embodied, inter(active) vision is reasoning over alternative hypotheses about the dynamics of perceived objects and events, be it for real-time or even offline interpretation. Towards this, we address the problem of generating and ranking grounded visuospatial hypotheses based on a semantically encoded notion of hypothesis preference. Driven by probabilistic Answer Set Programming (ASP), we propose a general framework for modeling and reasoning about diverse preference types tailored to visuospatial interpretation tasks. The effectiveness of our probabilistic visuospatial hypotheses ranking method is demonstrated and evaluated with a community benchmark of Multi-Object Tracking (MOT17), where modeling uncertainty and preference is critical for robust scene interpretation. Furthermore, practical examples also showcase how semantically driven reasoning with preferences can be effectively used in real-world visual sensemaking tasks.} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_ilvesmaiki_2025_1, title = {Probabilistic Approach to Data Editing : Contributions to Editing in Survey Sampling}, author = {Ilves, Maiki}, year = {2025}, url = {1946896}, language = {eng}, publisher = {Örebro University}, keywords = {data editing; selective editing; measurement error; survey statistics}, abstract = {The efficiency and quality of data editing processes are challenges for National Statistical Institutes (NSIs) in producing reliable official statistics. The traditional approach to data editing, heavily reliant on manual interventions, is resource-intensive and may introduce biases, impacting the overall accuracy of statistical estimates. This thesis aims to address these challenges by developing an in-novative editing framework based on probabilistic theory, allowing for a more resource-efficient editing process while providing accurate estimates of data quality. Furthermore, the thesis proposes an estimation procedure that accounts for various error sources, offering unbiased estimates of population parameters with appropri-ate measures of accuracy.In addition to the introductory part, the thesis is structured around four key papers, each contributing to the overall objective of improving data editing and estimation processes in official statistics. Paper I presents a combined selective and probabilistic editing approach that maintains data quality while reducing resource demands. Paper II explores the integration of probabilistic editing with generalized regression (GREG) estimation, demonstrating improved accuracy in population parameter estimation. Paper III extends the framework to address nonresponse errors alongside measurement errors, using a three-phase sampling setup. Paper IV investigates the impact of various score functions in the probabilis-tic editing framework, emphasizing the importance of selecting effective score functions to minimize variance and improve estimate accuracy. Each paper contains, in addition to a theoretical part, an empirical section where concepts are numerically illustrated based on either real data or synthetic data.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_akramowasim_2025, title = {Problematizing Silence in Research Involving Vulnerable Older Adults}, author = {Akram, Owasim and Baxter, Rebecca}, year = {2025}, journal = {International Journal of Qualitative Methods}, volume = {24}, doi = {10.1177/16094069251354848}, url = {1979919}, language = {eng}, publisher = {Sage Publications}, keywords = {ageing; silence; bangladesh; extreme poverty; research methods; philosophy sciencee}, abstract = {Millions of older people are living in extreme around the world. Experience suggests that such groups of people often respond with silence in research to express their social position and lived experience of impoverishment, vulnerability, oppression, and marginalization. However, understanding the eloquence that exists within the expression of silence is an empirically neglected phenomenon in scientific research, especially in studies that engage vulnerable older adults. This article, with support from practical experience and example interviews, leans towards a decolonial position that older people living in extreme poverty form a subaltern subclass who may express their lived experience using episodes of silence. The silence of vulnerable older people in research hints at a possible explanation for their silence in politics and policy discourse. Thus, it is crucial to consider silence as an empirical and primary text to illuminate perspectives of ageing within the lived context of poverty. This article intends to inspire methodological discussion as a step towards formulating strategies to empirically address silence in qualitative research involving vulnerable older adults living in poverty.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_burmanlovisa_2025, title = {Profiles of parents' upward and downward comparisons and their associations with parenting}, author = {Burman, Lovisa and Jonsson, Johanna and Glatz, Terese and Mouton, Benedicte}, year = {2025}, journal = {Family Relations}, volume = {74}, number = {5}, pages = {2878--2899}, doi = {10.1111/fare.70007}, url = {1985398}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {cluster analysis; parental self-efficacy; parenting practices; parents' stress and depression}, abstract = {Objective: The aim of this study was to explore whether there are naturally occurring groups of parents who display different profiles of upward (i.e., comparing with those better off) and downward (i.e., comparing with those worse off) social comparisons, and if these differ on parental symptoms, self-efficacy, and positive parenting behaviors.Background: While social comparisons can contribute to self-evaluation and offer opportunities for self-improvement by providing new information, they may also be associated with less positive parenting. One reason for different outcomes is the type of comparisons (i.e., upward or downward), which has not been studied using person-oriented analysis within the parenting literature.Method: A sample of 187 parents of children aged between 2 to 5 years were included (85% mothers and 15% fathers). Cluster analysis was used to explore profiles of parents depending on their upward and downward social comparisons, and analyses of variance were used to examine mean level differences. Results: Results yielded a four-cluster solution. In general, engaging in upward or downward social comparisons were associated with less positive outcomes. However, parents in the cluster who did predominantly upward comparisons showed more parental symptoms and less positive parenting.Conclusion: The frequency and direction of social comparisons are important, with parents engaging in predominantly upward comparisons showing the greatest vulnerability.ImplicationsPractitioners can help parents to reflect on their comparisons and to identify parents who focus mostly on others who they believe are doing better.}, issn = {0197-6664} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_deprezjulie_2025, title = {Prognostic factors for incontinence-associated dermatitis (IAD) : Results of an international expert survey}, author = {Deprez, Julie and Kottner, Jan and Eilegård Wallin, Alexandra and Bååth, Carina and Hommel, Ami and Hultin, Lisa and Josefson, Anna and Beeckman, Dimitri}, year = {2025}, journal = {Journal of tissue viability}, volume = {34}, number = {4}, doi = {10.1016/j.jtv.2025.100952}, url = {1995790}, language = {eng}, publisher = {Elsevier}, keywords = {delphi method; dermatitis; expert opinion; prognosis; risk factors}, abstract = {BACKGROUND: Incontinence-associated dermatitis (IAD) is a prevalent and distressing form of irritant contact dermatitis caused by prolonged exposure to urine and/or faeces. Not all incontinent individuals develop IAD, suggesting that additional prognostic factors contribute to its onset. The quality of empirical evidence supporting risk factors for IAD development is moderate to very low. Therefore, it is necessary to systematically compile and analyse expert knowledge on this topic.AIM: This study aimed to identify and prioritise key prognostic factors for IAD development through an international expert consultation.MATERIALS AND METHODS: A cross-sectional expert survey was conducted among international experts using an electronic survey platform. Participants rated the importance of 26 pre-identified prognostic factors, ranked relevant factors and suggested additional factors. Data were analysed to determine expert consensus and factor rankings.RESULTS: A total of 45 experts participated, with a response rate of 39 %. The highest-ranked prognostic factors included double incontinence, faecal incontinence, loose stools, stool frequency, urinary incontinence, and impaired mobility. Other important factors were advanced age, friction and shear forces, cognitive impairment, and poor nutrition. In addition, experts highlighted systemic factors such as caregiver knowledge gaps and staff shortages as potential contributors to IAD risk.CONCLUSION: Study results support established risk factors for IAD development such as stool frequency and limited mobility. Experts also identified factors, such as higher age and the presence of loose or liquid stool, that are considered relevant by experts but are not yet fully supported by empirical evidence. Findings will inform a future large-scale cohort study.}, issn = {0965-206X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tegneliuseva_2025, title = {Prognostic role of Ki-67 in high-risk estrogen receptor-positive/HER2 negative early breast cancer : a population-based cohort study}, author = {Tegnelius, Eva and Ahlgren, J. and Valachis, A.}, year = {2025}, journal = {ESMO Real World Data and Digital Oncology}, volume = {10}, doi = {10.1016/j.esmorw.2025.100647}, url = {2023175}, language = {eng}, publisher = {Elsevier}, keywords = {early breast cancer; adjuvant; cdk4/6; ki67; real world data}, abstract = {Background and purpose: Abemaciclib is a CDK4/6-inhibitor approved for adjuvant use in estrogen receptor (ER)positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer with high risk of relapse, defined as N2-N3 disease or high-risk N1 disease. The MonarchE study also included high Ki-67 in combination with N1 disease as a separate study cohort. We investigated the prognostic value of MonarchE risk group criteria, with or without the addition of Ki-67, when applied to a large set of real-world data (RWD).Materials and methods: We carried out a retrospective cohort study using Breast Cancer Data Base Sweden (BCBaSe) 3.0, a research database including all Swedish breast cancer patients from 2008 to 2020. The cohort included 21 110 ER-positive/HER2-negative breast cancer patients, whereof 12 983 had available Ki-67 data.Results: Risk groups were defined as N1 low risk, N1 high risk and N2-N3 very high risk, based on MonarchE criteria. Survival analyses showed an increasingly worse prognosis across the three groups for three outcomes including distant disease-free survival (DDFS), breast cancer-specific survival (BCSS), and overall survival (OS). Ki-67 >= 20% was associated with statistically significant worse DDFS, BCSS, and OS in the overall N1 group, but when comparing 5-year survival rates in the N1 group with and without Ki-67 stratification, no clinically meaningful absolute difference in OS was seen.Conclusions: Our nationwide RWD results support the use of MonarchE's risk group criteria for selection of high-risk ER-positive/HER2-negative breast cancer patients who might derive benefit from adjuvant abemaciclib. The role of Ki-67 in risk stratification seems to be limited and without clear clinical significance.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mondellostefania_2025, title = {Prognostic Value of Blood-Based Protein Biomarkers in Traumatic Brain Injury : A Living Systematic Review and Meta-Analysis}, author = {Mondello, Stefania and Amrein, Krisztina and Czeiter, Endre and Citerio, Giuseppe and Diaz-Arrastia, Ramon and Gao, Guoyi and Lagares, Alfonso and Manley, Geoffrey T. and Menon, David K. and Newcombe, Virginia and Posti, Jussi P. and Wilson, Lindsay and Zetterberg, Henrik and Steyerberg, Ewout W. and Büki, Andras and Maas, Andrew I. R.}, year = {2025}, journal = {Journal of Neurotrauma}, volume = {42}, number = {15-16}, pages = {1256--1286}, doi = {10.1089/neu.2024.0620}, url = {1962987}, language = {eng}, publisher = {Mary Ann Liebert}, keywords = {biomarkers; living systematic review; meta-analysis; prognosis; traumatic brain injury}, abstract = {Circulating biomarkers might improve the prediction of outcomes in patients with traumatic brain injury (TBI) beyond current approaches. Robust and up-to-date evidence is required to support their clinical utility and integration into medical practice to guide decision-making. Our objective was to critically appraise the existing evidence for six core blood-based TBI biomarkers (S100 calcium-binding protein B, glial fibrillary acidic protein [GFAP], neuron-specific enolase, ubiquitin C-terminal hydrolase-L1 [UCH-L1], tau and neurofilament proteins), in predicting outcome after TBI. Electronic databases, including Medline and Embase, were searched for articles published from their inception to October 2023. Studies were included if they evaluated the accuracy of blood biomarker concentrations at hospital presentation for outcome prediction in adult patients with TBI. Outcomes assessed were mortality, Glasgow Outcome Scale (GOS)/GOS extended (GOS-E), or the Rivermead Post-Concussion Symptoms Questionnaire (RPQ). Study selection, data extraction, and quality assessment using the modified Quality Assessment of Prognostic Accuracy Studies tool were performed by two authors independently, with disagreements being resolved through discussion or arbitration. If appropriate, a meta-analysis was conducted by calculating the weighted summary area under the curve (AUC) and using a bivariate regression model. Of 12,792 retrieved records, 32 articles, including 7481 patients with TBI, were selected as relevant. Two biomarkers showed strong associations with in-hospital and 6-month mortality: GFAP (unadjusted pooled AUC 0.81 [95% confidence interval [CI] 0.75-0.87] and 0.82 [0.80-0.85], respectively) and UCH-L1 (0.80 [0.74-0.85] and 0.83 [0.77-0.88]). Their addition to models that included established risk factors consistently improved the predictive value, though models and performance varied substantially across studies. In four studies measuring both markers, UCH-L1 outperformed GFAP in improving risk stratification when added to established prediction models. At similar to 1.5 ng/mL (five studies), the summary sensitivity of GFAP for predicting mortality was 78% (95% CI 67-85%), and the summary specificity was 79% (95% CI 64-89%). The other assessed biomarkers had fair to good performance in mortality prediction with unclear added benefits. Neurofilament light (NfL) (three studies) demonstrated the strongest association in predicting a 6-month poor outcome (GOS-E <= 4; GOS <= 3) (unadjusted pooled AUC 0.81 [95% CI 0.75-0.87]), whereas the other assessed biomarkers had a fair performance with unclear or irrelevant added value. All core biomarkers had only marginal or no association with incomplete recovery and post-concussion symptoms/syndrome, as assessed by RPQ. Serious problems were found in the design and analysis of many of the studies. We conclude that admission measurements of core blood TBI biomarkers, in particular GFAP and UCH-L1, are strongly associated with mortality. There remains little evidence that any of these markers are ready for clinical implementation for prognostic purposes. Future work focused on the intended use and applying unbiased rigorous analysis methods is necessary to demonstrate that the biomarker test results are "prognostically actionable."}, issn = {0897-7151} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_teledahlanna_2025, title = {Progression i elevers begreppsmässiga kunskap om bråk som delar av helhet}, author = {Teledahl, Anna and Harvey, Frida and Esbjörner, Magnus and Von Malortie, Samuel}, year = {2025}, journal = {Forskning om undervisning och lärande}, volume = {13}, number = {2}, pages = {70--95}, doi = {10.61998/forskul.v13i2.25297}, url = {1996630}, language = {swe}, publisher = {Lärarstiftelsen}, keywords = {conceptual knowledge; fractions; progression; begreppslig kunskap; tal i bråkform}, abstract = {För att utveckla elevers begreppsliga kunskap i matematik behöver lärare ha djupa insikter om elevers kunskapsprogression, men forskning visar att detta varierar stort mellan lärare. Studiens syfte är att bidra med förståelse för hur elevers begreppsliga kunskap om tal i bråkform som delar av helhet kan beskrivas som handlingar på olika kvalitativa nivåer. Grundskoleelevers skriftliga lösningar på problem som handlar om tal i bråkform har analyserats med fokus på om eleverna identifierar, urskiljer eller använder olika egenskaper, principer och relationer hos och mellan begrepp. Resultatet visar fyra nivåer där elever går från att urskilja och identifiera ett fåtal egenskaper och princi-per, hos begrepp som de har svårt att använda, till att urskilja flera egenskaper och principer vars relationer de sedan använder för att dra slutsatser. Denna progressionsbeskrivning kan användas praktiskt för att planera för undervis-ning som utvecklar elevers begreppsliga kunskap men också som teoretisk utgångspunkt för liknande studier inom andra matematikområden.;To develop students' conceptual understanding in mathematics, teachers need deep insights into students' knowledge progression; however, research shows that this varies significantly among teachers. This study aims to contribute to an understanding of how students' conceptual knowledge of fractions as parts of a whole can be described in terms of actions on different qualitative levels. Elementary students' written solutions to problems involving fractions have been analyzed with a focus on whether the students identify, discern, or usevarious properties, principles, and relationships within and between concepts. The results show four levels, where students progress from discerning and identifying a few properties and principles—within concepts they struggle to use—to discerning multiple properties and principles whose relationships they then use to draw conclusions. This description of progression can be applied practically to plan teaching that develops students' conceptual understanding, and also serves as a theoretical starting point for similar studies in other areas of mathematics.}, issn = {2000-9674} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisioannis_2025_12, title = {Promise and challenges of mesenchymal stromal cell therapy in severe SLE}, author = {Parodis, Ioannis}, year = {2025}, journal = {The Lancet Rheumatology}, volume = {7}, number = {4}, pages = {e224--e226}, doi = {10.1016/S2665-9913(24)00351-5}, url = {1923383}, language = {eng}, publisher = {Elsevier} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_rietzfinn_2025, title = {Prompt Tuning Decision Transformers with Structured and Scalable Bandits}, author = {Rietz, Finn and Smirnov, Oleg and Karimi, Sara and Cao, Lele}, year = {2025}, url = {2021024}, language = {eng}, abstract = {Prompt tuning has emerged as a key technique for adapting large pre-trained Decision Transformers (DTs) in offline Reinforcement Learning (RL), particularlyin multi-task and few-shot settings. The Prompting Decision Transformer (PDT)enables task generalization via trajectory prompts sampled uniformly from expertdemonstrations – without accounting for prompt informativeness. In this work, wepropose a bandit-based prompt-tuning method that learns to construct optimal trajectory prompts from demonstration data at inference time. We devise a structuredbandit architecture operating in the trajectory prompt space, achieving linear ratherthan combinatorial scaling with prompt size. Additionally, we show that the pretrained PDT itself can serve as a powerful feature extractor for the bandit, enablingefficient reward modeling across various environments. We theoretically establishregret bounds and demonstrate empirically that our method consistently enhancesperformance across a wide range of tasks, high-dimensional environments, andout-of-distribution scenarios, outperforming existing baselines in prompt tuning.}, file = {https://oru.diva-portal.org/smash/get/diva2:2021024/FULLTEXT02.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_rietzfinn_2025_1, title = {Prompt-Tuning Bandits : Enabling Few-Shot Generalization for Efficient Multi-task Offline RL}, author = {Rietz, Finn and Smirnov, Oleg and Karimi, Sara and Gao, Lele}, year = {2025}, volume = {2640}, pages = {31--40}, doi = {10.1007/978-981-95-0988-1_3}, url = {2017725}, language = {eng}, publisher = {Springer}, abstract = {Prompting has emerged as the dominant paradigm for adapting large, pre-trained transformer-based models to downstream tasks. The Prompting Decision Transformer (PDT) enables large-scale, multitask offline Reinforcement Learning (RL) pre-training by leveraging stochastic trajectory prompts to identify the target task. However, these prompts are sampled uniformly from expert demonstrations, overlooking a critical limitation: not all prompts are equally informative for differentiating between tasks. This limits generalization and adaptation, especially in low-data or open-world settings where sample efficiency is crucial. To address this issue, we propose a lightweight, inference-time, bandit-based prompt-tuning framework. The bandit explores and optimizes trajectory prompt selection to enhance task performance, while avoiding costly fine-tuning of the transformer backbone. Our experiments indicate not only clear performance gains due to bandit-based prompt-tuning, but also better sample complexity, scalability, and prompt space exploration compared to prompt-tuning baselines. These results highlights the importance of adaptive prompt selection mechanisms for efficient generalization in offline multi-task RL.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_pleusstefan_2025_1, title = {Proposed minimum requirements for market approval of continuous glucose monitoring (CGM) systems : A viewpoint from the IFCC working group on CGM}, author = {Pleus, Stefan and Eichenlaub, Manuel and Eriksson Boija, Elisabet and Diem, Peter and Fokkert, Marion and Hinzmann, Rolf and Jendle, Johan and Klonoff, David C. and Makris, Konstantinos and Nichols, James H. and Pemberton, John and Selvin, Elizabeth and Slingerland, Robbert J. and Thomas, Andreas and Tran, Nam K. and Witthauer, Lilian and Freckmann, Guido}, year = {2025}, journal = {Diabetes, obesity and metabolism}, volume = {27}, number = {7}, pages = {4039--4042}, doi = {10.1111/dom.16420}, url = {1955128}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, issn = {1462-8902} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nyberglisa_2025, title = {Prospective observational study of tofacitinib in ulcerative colitis : analysis of clinical data, fatigue and health-related quality of life during the induction phase}, author = {Nyberg, Lisa and Halfvarson, Jonas and Söderling, Jonas and Olén, Ola and Strid, Hans and Hedin, Charlotte R. H. and Jónsdóttir, Sara B. and Hjortswang, Henrik and Jäghult, Susanna and Cappelleri, Joseph C. and Henrohn, Dan and Seddighzadeh, Maria and Marsal, Jan and Grip, Olof}, year = {2025}, journal = {Therapeutic Advances in Gastroenterology}, volume = {18}, doi = {10.1177/17562848251343427}, url = {1975350}, language = {eng}, publisher = {Sage Publications}, keywords = {jak inhibitor; fatigue; health-related quality of life; tofacitinib; ulcerative colitis}, abstract = {BACKGROUND: Tofacitinib is a Janus kinase inhibitor for the treatment of ulcerative colitis (UC). Prospective real-world data are scarce.OBJECTIVES: To collect data on clinical outcomes, including health-related quality of life (HRQoL) and fatigue during treatment with tofacitinib. DESIGN: This is a prospective observational multicentre study in Sweden. In this analysis, outcomes at weeks 2, 8 and 16 are reported.METHODS: Patients with active UC confirmed with endoscopy or faecal calprotectin (FC) were enrolled during 2020-2023 when starting tofacitinib therapy.RESULTS: In total, 103 patients were included. After 2 weeks of treatment, 50% (39/78) had achieved symptomatic response and at week 16, 39% (35/89) had achieved corticosteroid-free clinical remission according to the partial Mayo score. At week 16, a reduction in FC by ⩾50% was seen in 49% (35/71) and 24% (11/46) were in endoscopic remission. The frequency of arthralgia decreased from 29% (30/103) at baseline to 11% (10/89) at week 16. Regarding HRQoL at week 16; each of the four Short Health Scale dimensions (symptoms, social function, disease-related worry and general well-being) had improved by a median of 1 point (p < 0.01) and the European Quality of Life 5 Dimensions 5 Levels index improved from 0.80 to 0.87. Finally, the Inflammatory Bowel Disease Fatigue score measuring occurrence and severity showed an improvement with a decrease from 9 points at baseline to 6 at week 16 (p < 0.05).CONCLUSION: Induction therapy with tofacitinib therapy was associated with improvements in patient-reported outcome measures of symptoms, endoscopic activity, arthralgia, HRQoL and fatigue. These real-world data illustrate that tofacitinib is a fast-acting drug with broad therapeutic effects in UC. CLINICALTRIAL REGISTRATION NUMBER: NCT04338204.}, issn = {1756-283X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_moralesluisorlando_2025, title = {Protection of Photosynthesis by UVR8 and Cryptochromes in Arabidopsis Under Blue and UV Radiation}, author = {Morales, Luis Orlando and Shapiguzov, Alexey and Rai, Neha and Aphalo, Pedro José and Brosché, Mikael}, year = {2025}, journal = {Plant, Cell and Environment}, volume = {48}, number = {8}, pages = {6321--6335}, doi = {10.1111/pce.15608}, url = {1957694}, language = {eng}, publisher = {Blackwell Publishing}, keywords = {arabidopsis; uv radiation; uvr8; blue light; cryptochromes; photoprotection; photosynthesis}, abstract = {Photosynthesis in plants is negatively affected by high light intensity and UV radiation. The photoreceptors UV RESISTANCE LOCUS 8 (UVR8) and CRYPTOCHROMES (CRYs) mediate perception and acclimation of plants to UV-B/UV-A2 (290-340 nm) and UV-A1/blue light (350-500 nm), respectively. However, their roles in photoprotection of photosynthesis across different wavebands of the spectrum remain unclear. Using chlorophyll fluorescence and LED lighting we studied the roles of UVR8 and CRYs in maintaining photosynthetic capacity in Arabidopsis exposed to UV-B, UV-A1, and blue light. Analysis of quantum yield of Photosystem II, nonphotochemical quenching, and LHCII phosphorylation demonstrated that CRYs preserve photosynthetic performance in plants exposed to UV-B, UV-A1, and blue light. UVR8 and CRYs exhibit partially redundant functions in maintaining photosynthetic activity under UV-B, UV-A1, and blue light, and in preventing photodamage under high UV-A1 irradiance. Impaired UVR8 and CRY signalling reduced epidermal flavonol accumulation in leaves, which further compromised photoprotection. These findings provide valuable insights into how UV and blue light perception contribute to photoprotection, with broad implications for plant performance both in natural and managed environments.}, issn = {0140-7791} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_engelheartstina_2025, title = {Protein Intake and Its Association With Meal Patterns and Dietary Patterns in a Swedish Population of Older Adults}, author = {Engelheart, Stina and Karlsson, Mikael and Lentjes, Marleen}, year = {2025}, journal = {Journal of human nutrition and dietetics}, volume = {38}, number = {1}, doi = {10.1111/jhn.70011}, url = {1928456}, language = {eng}, publisher = {Wiley-Blackwell}, keywords = {dietary pattern; meal pattern; older adults; protein bolus; protein intake; protein sources}, abstract = {BACKGROUND: Meeting protein intake recommendations is relevant for maintaining muscle mass. This study aimed to describe protein intake and its association with meal patterns and dietary patterns.METHODS: An in-house designed, web-based 4-day record was used in the national dietary survey (in 2010/2011). Participants 60 years and older were included in the analysis (n = 533). Protein intake was described by hour of consumption, self-indicated meals and food source. Eating and drinking occasion (EDO) and food groups were defined, from which meal patterns and three a posteriori dietary patterns (using principal component analysis) were assessed.RESULTS: We observed a mean protein intake of just over 1 g/kg body weight (bw) in both men and women. Over 50% of the protein intake was sourced from the food groups meat, fish and milk/yoghurt. A bolus intake of 30 g protein per meal was observed in a small proportion of participants at breakfast and lunch, but was most common at dinner (41% women and 56% men). No strong correlations were observed between protein intake and neither dietary patterns nor the number of EDOs. A 5 g higher protein intake at any meal, but not higher EDO frequency, was associated with higher odds of meeting a protein intake over 1.1 g/kg bw.CONCLUSIONS: Protein intake over 1.1 g/kg bw was met by 44% of the participants. Lunch and dinner were the highest contributors to protein intake. Dietary and meal patterns were weakly associated with protein intake. Only total daily protein intake was associated with reaching > 1.1 g/kg bw.}, issn = {0952-3871} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_salomonbenita_2025_2, title = {Proteomics and Metabolomics in Inflammatory Bowel Disease : Subtype Characterisation and Prognosis}, author = {Salomon, Benita}, year = {2025}, url = {1996444}, language = {eng}, publisher = {Örebro University}, keywords = {inflammatory bowel disease; ulcerative colitis; crohn’s dis-ease; proteomics; metabolomics; inception cohort; biomarkers; prognosis}, abstract = {Inflammatory bowel disease (IBD) exhibits significant heterogeneity, encompassing variation in affected gastrointestinal segments and disease course, both within and between subtypes. Proteomics and metabolomics may offer insights into the IBD spectrum and serve as a basis for biomarker discovery, thereby addressing healthcare challenges and advanc-ing our understanding of disease mechanisms. The overall aim of this thesis was to investigate proteomics and metabolomics in relation to IBD.Patient cohorts are the foundation for many observational studies. In study I, we described the Swedish Inception Cohort in IBD (SIC-IBD), which was used for several subsequent studies. Based on serum proteins, we observed colonic Crohn’s disease (CD) as an intermediate subtype between ileal CD and ulcerative colitis (UC) in study II. In study III, we identified mucosal markers associated with an aggressive course of UC (e.g., MMP-1 and OPG) and developed a mucosal protein signature to predict the disease course. Mucosal angiotensin-converting enzyme 2 (ACE2) levels did not differ between IBD and symptomatic or healthy controls in study IV, but levels were higher in inflamed compared to non-inflamed ileal biopsies from patients with CD. In study V, we found metabolites associated with incident paediatric IBD compared with symp-tomatic controls, among these a positive association for aryl sulfate.In this thesis, we examined serum proteins, mucosal proteins and exposome-related metabolites in IBD. We identified differences between subtypes of IBD, between inflamed versus non-inflamed tissue, as well as between IBD, symptomatic and healthy controls. These results may inform further biomarker research and support a molecular stratification of IBD.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_jmtejan_2025_2, title = {Protest, politik och påverkan i efterkrigstidens Sverige}, author = {Jämte, Jan and Lundstedt, Måns}, year = {2025}, pages = {357--376}, url = {1967892}, language = {swe}, publisher = {Studentlitteratur AB}, keywords = {sociala rörelser; politiska protester; aktivism; demokrati; politiska följder; kulturella följder}, abstract = {I detta kapitel tar vi ett samlat grepp om boken Sociala rörelser i Sverige. Från att ha betraktat rörelserna var för sig försöker vi lyfta fram gemensamma drag och utvecklingslinjer. Vilka idéer förenar olika rörelser? Hur har deras sätt att protestera förändrats över tid? Finns det mönster i sätten att organisera sig? Och hur kan vi egentligen förstå deras avtryck och betydelse för den svenska samhällsutvecklingen? I kapitlet lyfter vi således fram likheter, skillnader och historiska drag i rörelsernas idéer, handlingsreperto­arer, organisationsformer och samhällsbetydelse.Trots att de femton rörelse som beskrivits i boken mobiliserat kring olika politiska sakfrågor och använt delvis olika strategier har de också haft mycket gemensamt. Genom att anlägga ett mer övergripande perspektiv kan vi synliggöra ett antal mer dominerande tankefigurer som flera rörelser samlats kring. Vi visar också hur samhällets och politikens syn på olika protestformer förändrats över tid, och vi diskuterar förhållandet mellan rörelsers val av organisationsformer och det vidare samhälleliga sammanhang de verkar i.Kapitlet avslutas med en analys av de sociala rörelsernas betydelse för samhällets och politikens utveckling efter andra världskriget. På så sätt bidrar kapitlet med en historieskrivning som sätter sociala rörelser i centrum, där det svenska samhällets utveckling speglas genom rörelsernas aktivitet.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bentzerpeter_2025, title = {Protocolized REDUction of Non-Resuscitation Fluids in SEptic Shock Patients : A Protocol for the REDUSE Randomized Clinical Trial}, author = {Bentzer, Peter and Lindén, Anja and Olsen, Markus H. and Lilja, Gisela and Fisher, Jane and Sjövall, Fredrik and Kander, Thomas and Lengquist, Maria and Samuelsson, Line and Undén, Johan and Palmnäs, Ewa and Oras, Jonatan and Cronhjort, Maria and Balintescu, Anca and Lind, Alicia and Ahlström, Björn and Meirik, Maria and Savilampi, Johanna and Pekkarinen, Pirkka and Berggren, Anna and Oscarsson, Nicklas and Said, Mohammed and Castegren, Markus and Faria, Susanne and Hemberg, Linn and Linder, Adam and Lipcsey, Miklos and Skrifvars, Marcus B. and Wise, Matt P. and Nielsen, Niklas and Jakobsen, Janus C.}, year = {2025}, journal = {Acta Anaesthesiologica Scandinavica}, volume = {69}, number = {7}, doi = {10.1111/aas.70095}, url = {1988472}, language = {eng}, publisher = {John Wiley & Sons}, abstract = {In septic shock, administration of large fluid volumes is associated with poor outcomes. Recent evidence shows that non-resuscitation fluids are the major modifiable source of fluids for patients with septic shock in intensive care units (ICUs). This clinical trial is designed to test the hypothesis that restrictive administration of non-resuscitation fluids improves outcomes compared to usual care. Adult patients admitted to ICUs with septic shock will be randomly assigned within 12 h of admission to receive protocolized restrictive administration of non-resuscitation fluids or usual care. The primary outcome is all-cause mortality at 90 days. Secondary outcomes are complications during ICU stay up to 90 days (defined as any acute kidney injury or cerebral, coronary, intestinal, or limb ischemia), mechanical ventilation free days within 90 days, and for survivors cognitive function (by the Montreal Cognitive Assessment [MOCA-BLIND]) and Health-Related Quality of Life (by the EQ Visual Analogue Scale [EQ-VAS]), both at 6 months. In addition, the climate impact of the interventions will be assessed. To detect an absolute reduction in mortality of 7.5%, with an alpha of 5% and a power of 90%, we aim to include 1850 patients. The trial is approved by the Swedish Ethical Review Authority. Results of primary and secondary clinical outcomes and the environmental outcome will be submitted for publication in a peer-reviewed journal.Trial Registration: NCT06140147.}, issn = {0001-5172} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lfstrandkarin_2025, title = {Providing a new transdiagnostic emotion-focused pain treatment in a clinical context : therapists' experiences of facilitators and barriers}, author = {Löfstrand, Karin and Björk Brämberg, Elisabeth and Flink, Ida and Wurm, Matilda and Bergbom, Sofia}, year = {2025}, journal = {Cognitive Behaviour Therapy}, volume = {54}, number = {6}, pages = {729--747}, doi = {10.1080/16506073.2024.2417426}, url = {1908046}, language = {eng}, publisher = {Routledge}, keywords = {implementation; chronic pain; cognitive behavioral therapy; comorbidity; consolidated framework of implementation research}, abstract = {Providing new psychological treatments in clinical settings requires implementation strategies adapted to the organizational context. This study explored how licensed psychologists experienced their context when providing a new transdiagnostic psychological treatment, "the hybrid treatment", to treat comorbid pain and emotional problems in a clinical setting. We aimed to identify which contextual factors the therapists experienced as facilitating or hindering, to gain a better understanding of important considerations when planning a future implementation strategy. Contextual factors were identified using the Consolidated Framework of Implementation Research (CFIR) in data collection and analysis. Data were collected through semi-structured interviews (N = 9). Thematic analysis resulted in the identification of five main influencing factors: Perception of the intervention's adaptability, prioritization of the patient's needs, leadership engagement, structure for collaboration, and therapists' professional engagement. The results highlight the importance of ensuring a clearly stated mandate for the key individuals involved. The findings may guide future implementation of new psychological treatments into regular care, to enhance facilitators and overcome barriers.}, issn = {1650-6073} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindowmartin_2025, title = {Psychiatrists' experiences with the implementation of safewards and other quality improvement work : an explorative, qualitative interview study}, author = {Lindow, Martin and Tyrberg, Mårten J. and Pelto-Piri, Veikko and Björkdahl, Anna}, year = {2025}, journal = {BMC Psychiatry}, volume = {25}, number = {1}, doi = {10.1186/s12888-025-07058-x}, url = {1970084}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {coercion; engagement; implementation; psychiatrist; quality improvement; safewards; violence prevention}, abstract = {BACKGROUND: Restrictive practices, such as seclusion and restraint, in psychiatric inpatient settings carry significant risks of harm and raise critical ethical concerns, which has prompted efforts to minimize their use. Models like Safewards, with its ten interventions, have shown promise in reducing conflict and containment but require active engagement from all healthcare professionals. Despite their leadership roles, psychiatrists' engagement in implementing Safewards remains underexplored, even though their involvement is likely critical for the model's success. This study aimed to identify key facilitators and barriers to psychiatrists' engagement in implementing Safewards and other quality improvement work.METHODS: In this qualitative exploratory study, semi-structured interviews and inductive content analysis were utilized. Ten psychiatrists from nine psychiatric clinics in Sweden, providing both voluntary and involuntary care and implementing Safewards to varying extents, were recruited via convenience sampling. Participants, equally distributed by gender, had an average of 12 years of experience in their roles. Interviews were conducted in person or digitally, lasting 30-90 min, and transcribed verbatim. Data were analyzed using qualitative content analysis, with coding and categorization conducted collaboratively to ensure consistency. Reflexive practice and the COREQ checklist were applied to enhance trustworthiness.RESULTS: Psychiatrists' engagement in Safewards and quality improvement efforts was influenced by factors tied to their professional role and the clinical work environment. Positive influences included leadership aspects, professional training, and visible benefits for patient care, such as improved communication with patients and staff. Barriers included a narrow care perspective, feelings of detachment from holistic patient care, and the unpredictable nature of psychiatrists' work. Time allocation, prioritization, and support from local management also played crucial roles in shaping engagement.CONCLUSIONS: This study identifies key facilitators and barriers to psychiatrists' engagement in implementing Safewards, offering guidance for enhancing their participation. Strengthening leadership, broadening perspectives, and ensuring protected time for quality improvement initiatives may optimize multidisciplinary collaboration. Future research should examine whether increased psychiatrist participation positively affects Safewards outcomes. TRIAL REGISTRATION: Clinical trial number: not applicable.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_unengehallerbckmaria_2025, title = {Psychological distress in single fathers and mothers : a Swedish population-based study}, author = {Unenge Hallerbäck, Maria and Molarius, Anu and Karlsson, Linn and Sonnby, Karin}, year = {2025}, journal = {Scandinavian Journal of Public Health}, doi = {10.1177/14034948251332507}, url = {1951774}, language = {eng}, publisher = {Sage Publications}, keywords = {single parents; sweden; mental health; parental support; population studies}, abstract = {AIMS: The primary aim of the present study was to explore the prevalence of psychological distress among single fathers and single mothers in comparison to parents living together, and the factors contributing to the differences between single and partnered parents. A secondary aim was to investigate the perceived need for parental support in relation to severe psychological distress in these groups.METHODS: A survey questionnaire was sent to a random population sample in Sweden in 2022 and 5750 parents aged 18-69 years participated. The outcome was severe psychological distress, measured by the Kessler-6 (scores ⩾13). Associations between single parenthood and severe psychological distress were analysed with multiple logistic regression, adjusting for age group, economic difficulties, social support, risk consumption of alcohol and need for parental support.RESULTS: Severe psychological distress was more common among single fathers (age-adjusted odds ratio (OR): 2.2; 95% confidence interval (CI): 1.4-3.5) and mothers (age-adjusted OR: 2.4; 95% CI: 1.8-3.3) than among partnered fathers and mothers. The main explanatory factors for the difference were economic difficulties and lack of social support, accounting together for 75% of the excess of severe psychological distress in single fathers and 64% in single mothers. Risk consumption of alcohol among both single and partnered fathers was also associated with severe psychological distress. Being in need of more parental support, for example, from maternity/child health care or family centres was associated with severe psychological distress among all parents, regardless of partnership status and gender.CONCLUSIONS: Single parents had a higher prevalence of severe psychological distress than partnered parents, mainly explained by economic difficulties and the lack of social support. Both among single and partnered parents, the need for more parental support was associated with severe psychological distress.}, issn = {1403-4948} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_glpenjoost_2025, title = {Psychological interventions for preventing relapse in individuals with partial remission of depression : a systematic review and individual participant data meta-analysis}, author = {Gülpen, Joost and Breedvelt, Josefien J.F. and van Dis, Eva A.M. and Geurtsen, Gert J. and Warren, Fiona C. and van Heeringen, Cornelis and Hitchcock, Caitlin and Holländare, Fredrik and Huijbers, Marloes J. and Jarrett, Robin B. and Jermann, Françoise and de Jonge, Margo and Klein, Daniel N. and Klein, Nicola S. and Ma, S. Helen and Moore, Michael T. and Denys, Damiaan A.J.P. and Williams, J. Mark G. and Kuyken, Willem and Bockting, Claudi L.}, year = {2025}, journal = {Psychological Medicine}, volume = {55}, doi = {10.1017/s0033291725000157}, url = {1938621}, language = {eng}, publisher = {Cambridge University Press}, keywords = {depression; individual participant data meta-analysis; major depressive disorder; mood disorder; partial remission; psychological interventions; quality of life; relapse prevention; residual symptoms; treatment}, abstract = {Partial remission after major depressive disorder (MDD) is common and a robust predictor of relapse. However, it remains unclear to which extent preventive psychological interventions reduce depressive symptomatology and relapse risk after partial remission. We aimed to identify variables predicting relapse and to determine whether, and for whom, psychological interventions are effective in preventing relapse, reducing (residual) depressive symptoms, and increasing quality of life among individuals in partial remission. This preregistered (CRD42023463468) systematic review and individual participant data meta-analysis (IPD-MA) pooled data from 16 randomized controlled trials (n = 705 partial remitters) comparing psychological interventions to control conditions, using 1- and 2-stage IPD-MA. Among partial remitters, baseline clinician-rated depressive symptoms (p = .005) and prior episodes (p = .012) predicted relapse. Psychological interventions were associated with reduced relapse risk over 12 months (hazard ratio [HR] = 0.60, 95% confidence interval [CI] 0.43–0.84), and significantly lowered posttreatment depressive symptoms (Hedges’ g = 0.29, 95% CI 0.04–0.54), with sustained effects at 60 weeks (Hedges’ g = 0.33, 95% CI 0.06–0.59), compared to nonpsychological interventions. However, interventions did not significantly improve quality of life at 60 weeks (Hedges’ g = 0.26, 95% CI -0.06 to 0.58). No moderators of relapse prevention efficacy were found. Men, older individuals, and those with higher baseline symptom severity experienced greater reductions in symptomatology at 60 weeks. Psychological interventions for individuals with partially remitted depression reduce relapse risk and residual symptomatology, with efficacy generalizing across patient characteristics and treatment types. This suggests that psychological interventions are a recommended treatment option for this patient population.}, issn = {0033-2917} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_martinsmiguel_2025, title = {Psychological State Experienced by Gastroenterologists following Endoscopic Adverse Events : Insights from a Nationwide Cross-Sectional Study}, author = {Martins, Miguel and Morais, Rui and Mendes, Francisco and Coelho, Rosa and Craciun, Ana and Gonçalves, Tiago Cúrdia and Brandão, Catarina and Pimentel-Nunes, Pedro and Santos-Antunes, João and Lopes, Susana and Trindade, Ines A. and Macedo, Guilherme}, year = {2025}, journal = {GE Portuguese journal of gastroenterology}, doi = {10.1159/000549616}, url = {2024099}, language = {eng}, publisher = {S. Karger}, keywords = {adverse events; healthcare profession; psychological impact}, abstract = {BACKGROUND: Adverse events (AEs) are unintentional patient outcomes expected in medicine, but their impact on physicians remains underexplored. OBJECTIVES: This study assessed the psychological state experienced by gastroenterologists following endoscopic AEs.METHODS: A nationwide online survey was sent to all registered gastroenterologists (n = 709). Psychological state was assessed using validated scales assessing psychological distress (DASS-21), professional quality of life (ProQOL-5), self-compassion (SCS-12), and shame feelings (OAS2). Results are presented as mean and 95% confidence interval.RESULTS: Seventy responded (9.87% response rate; median age 41; 41% female). Nearly all (99%) experienced AEs, most during polypectomy/mucosectomy (66%). None consulted psychological support. Stress (9.4 [7.3-11.5]), anxiety (5.1 [3.5-6.7]), and depression (5.2 [3.7-6.8]) were normal, while burnout (25.9 [24.5-27.2]) and traumatic stress (24.3 [23.0-25.5]) were moderate. Higher compassion satisfaction was associated with consultant status (41.5 vs. 37.7, p = 0.039), >10 years' experience (44.3 vs. 40.2, p = 0.032), age >50 years (41.9 vs. 39.3, p = 0.008) and those involved in legal actions (45.5 vs. 40.6; p = 0.023). Age >50 was also associated with higher stress (15.2 vs. 8.7, p = 0.023) and traumatic stress (26.3 vs. 23.8, p = 0.035). Stopping procedures after AEs was associated with higher anxiety (12.0 vs. 4.8, p = 0.026).CONCLUSIONS: This is among the first studies to assess the psychological state of AEs on gastroenterologists. Participants showed moderate burnout and traumatic stress, but none consulted psychological support. Findings highlight the need for targeted healthcare support and further research on the emotional burden of AEs among endoscopists.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ustadilara_2025, title = {Psychological stress and eating behaviors as interacting influences on patient-reported disease activity in Italian patients with inflammatory bowel disease}, author = {Usta, Dilara and Acampora, Marta and Pereira, Andresa Costa and Savarese, Mariarosaria and De Rocchis, Maria Stella and Avedano, Luisa and Leone, Salvo and Graffigna, Guendalina and Halfvarson, Jonas}, year = {2025}, journal = {Scientific Reports}, volume = {16}, number = {1}, doi = {10.1038/s41598-025-29573-3}, url = {2040801}, language = {eng}, publisher = {Nature Portfolio}, keywords = {comfort food; inflammatory bowel disease; patient engagement; patient-reported outcome measures; perceived stress; stress-eating}, abstract = {Diet and psychological stress are recognized contributors to inflammatory bowel disease (IBD), yet their interaction-particularly stress-induced eating-remains underexplored. This study examined how perceived stress relates to comfort food consumption (CFC) and patient-reported outcomes among individuals with IBD. A cross-sectional online survey was conducted with 2,254 Italian patients recruited via a national patient organization. Participants completed the Perceived Stress Scale, Salzburg Stress Eating Scale, IBD Symptom Inventory, Bristol Stool Chart, and ad hoc items on CFC. Analyses included partial correlations controlling demographic and clinical covariates, group comparisons by stress level and IBD subtype, and latent class analysis (LCA) to identify psychosocial profiles. Participants reported moderate stress and increased CFC under stress. Those with higher perceived stress described greater symptom burden, softer stool consistency, more frequent CFC, and stronger emotional reliance on these foods. The LCA identified two subgroups-one low-stress/low-symptom and another high-stress/high-symptom/high-comfort-food-highlighting a stress-reactive behavioral phenotype. Stress-eating scores and food preferences did not differ by disease subtype, although patients with Crohn's disease reported higher symptom severity and softer stools. Findings underscore perceived stress as a key psychological correlate of eating behaviors and symptom perception in IBD, supporting the integration of patient-reported experiences into multidisciplinary, engagement-oriented care.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_martingina_2025, title = {Psychometric properties of an Adapted Climate Change Coping Scale in a sample of Canadian adolescents}, author = {Martin, Gina and Treble, Matt and Dubois, Cerina and Ojala, Maria and Faulkner, Violeta and Roswell, Tasha and Card, Kiffer and Gilliland, Jason and Cosma, Alina}, year = {2025}, journal = {Wellbeing, Space and Society}, volume = {9}, doi = {10.1016/j.wss.2025.100325}, url = {2023676}, language = {eng}, publisher = {Elsevier}, keywords = {adolescents; climate change; coping; psychometrics; measurement instruments; survey; canada}, abstract = {Climate change is a threat to the health and wellbeing of adolescents. Many adolescents express concern, worry, and anxiety about climate change. Yet, how adolescents are coping with their thoughts and feelings about climate change is not well understood. The objective of this research was to explore the psychometric properties of an Adapted Climate Change Coping Scale (CCCS-A) in a non-probabilistic sample of approximately 800 Canadian adolescents. Exploratory factor analysis was utilized. Internal reliability was assessed, and convergent validity was examined through analysis of correlations with related constructs. Correlations with wellbeing and mental health measures were also explored. The results indicated that four dimensions of coping with thoughts and feelings about climate change (de-emphasizing, distracting, problem-focused coping, and meaning-focused coping) were operationalized through a scale with 16-items. This extends prior scales in that it includes both measures of de-emphasizing and distracting coping within a single survey tool. Evidence of construct validity was found, and the internal reliability of subscales were good (omega ranged from 0.79 to 0.88). The sub-scales showed evidence of convergent validity. Additionally, all coping dimensions were positively associated with wellbeing, while associations with mental health problems were mixed across coping dimensions. The CCCS-A is a survey tool with demonstrated validity and reliability that captures a range of coping strategies adolescents use in response to climate change. This addresses a critical gap in climate change and mental wellbeing research by presenting a validated tool to assess adolescent climate change coping mechanisms.}, issn = {2666-5581} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_cortesesamuele_2025_1, title = {Psychotic symptoms during pharmacological treatment of ADHD : clinical considerations and research needs}, author = {Cortese, Samuele and Garcia-Argibay, Miguel and Oliver, Dominic and Chang, Zheng and Farhat, Luis C. and Bloch, Michael H. and de Pablo, Gonzalo Salazar and Larsson, Henrik and Solmi, Marco and Correll, Christoph U. and Fusar-Poli, Paolo}, year = {2025}, journal = {Lancet psychiatry}, doi = {10.1016/S2215-0366(25)00248-2}, url = {2007341}, language = {eng}, publisher = {Elsevier}, abstract = {SummaryIn this Personal View, we address key questions to support evidence-based prevention and management of psychotic symptoms that might occur during ADHD pharmacotherapy. We begin by examining evidence showing a significantly increased occurrence of psychotic disorders in individuals with ADHD, independent of ADHD medications (pooled relative risk, odds ratio, or hazard ratio=4·74, 95% CI 4·11–5·46). We then examine whether ADHD medications play a causal role, noting that current evidence does not support such a causal link, at least for methylphenidate. We explore how vulnerability to psychosis varies across individuals with ADHD. Regarding the different steps involved in prescribing ADHD medications, we discuss the importance of balancing potential risks—such as emergence of psychotic symptoms—against the demonstrated benefits of pharmacological treatment for ADHD. Next, we present strategies for screening individuals for vulnerability to psychosis before initiating ADHD medication. We then offer guidance on the clinical management of psychotic symptoms that might arise during ADHD pharmacotherapy, including considerations of dosage and medication type. Finally, we identify key research priorities in this area. Overall, this paper provides an empirical framework, grounded in evidence and clinical practice, to guide the next steps in the field.}, issn = {2215-0374} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_matrnemarie_2025_2, title = {Psykosocialt stöd till patienter och närstående i rehabiliteringen efter stroke}, author = {Matérne, Marie}, year = {2025}, url = {2009105}, language = {swe} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_stenlundjrgen_2025, title = {Public Science Center Visitors’ Engagement with an Interactive Visualization of an Antarctic Food Web}, author = {Stenlund, Jörgen and Ignatenko, Sergey and Göransson, Andreas and Höst, Gunnar and Schönborn, Konrad}, year = {2025}, url = {1994297}, language = {eng}, keywords = {digital learning; multimodal learning; science museums}, abstract = {We investigate visitor interactions with, and responses to, EcoWebWater, a touch-based exhibit visualizing a 3D Antarctic food web. The aim is to gain knowledge about how public science center visitors engage with an interactive visualization about ecological relationships. The study employed a mixed-methods design using quantitative data from 995 visitor sessions logged at a science center, complemented by qualitative insights obtained through semi-structured interviews with five participants. The analysis focused on session durations, user behaviors, the nature of engagement, and responses to the exhibit. The quantitative analysis revealed patterns of engagement, categorizing session durations into short (<30 seconds), medium (30 seconds to 5 minutes), and long (>5 minutes) sessions. Longer sessions were characterised by exploratory behaviors, including increased page visits and food web interactions per session, while shorter sessions exhibited lower levels of engagement. The average session time was approximately two minutes, consistent with existing research on similar exhibits. Qualitatively, visitors demonstrated scientific reasoning, with interpretations ranging from correct to hybrid or incorrect. The exhibit also elicited a range of affective responses, e.g., curiosity and anxiety. However, user feedback indicated challenges with the 3D format, node density, and cognitive demands, which at times impeded usability and visual communication. This study provides new insights into public engagement with complex science visualizations, highlighting the importance of design considerations in enhancing accessibility and sustained interaction. The findings suggest potential design improvements to address identified challenges. Future research directions include exploring strategies to optimise user experience and increase engagement with interactive science center exhibits.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_thunbergsara_2025_6, title = {Qualitative research for a digital world : A practical guide, by Emmanuel Mogaji, Varsha Jain,and Himani Sharma, United Kingdom, Sage Publications Ltd., 2025}, author = {Thunberg, Sara}, year = {2025}, journal = {Journal of Urban Affairs}, doi = {10.1080/07352166.2025.2592471}, url = {2016886}, language = {eng}, publisher = {Routledge}, issn = {0735-2166} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tranhuynhkhanhvi_2025, title = {Quality attributes of test cases and test suites - importance & challenges from practitioners' perspectives}, author = {Tran, Huynh Khanh Vi and Ali, Nauman bin and Unterkalmsteiner, Michael and Borstler, Juergen and Chatzipetrou, Panagiota}, year = {2025}, journal = {Software quality journal}, volume = {33}, number = {1}, doi = {10.1007/s11219-024-09698-w}, url = {1929767}, language = {eng}, publisher = {Springer}, keywords = {software testing; test case quality; test suite quality; quality assurance}, abstract = {The quality of the test suites and the constituent test cases significantly impacts confidence in software testing. While research has identified several quality attributes of test cases and test suites, there is a need for a better understanding of their relative importance in practice. We investigate practitioners' perceptions regarding the relative importance of quality attributes of test cases and test suites and the challenges that they face in ensuring the perceived important quality attributes. To capture the practitioners' perceptions, we conducted an industrial survey using a questionnaire based on the quality attributes identified in an extensive literature review. We used a sampling strategy that leverages LinkedIn to draw a large and heterogeneous sample of professionals with experience in software testing. We collected 354 responses from practitioners with a wide range of experience (from less than one year to 42 years of experience). We found that the majority of practitioners rated Fault Detection, Usability, Maintainability, Reliability, and Coverage to be the most important quality attributes. Resource Efficiency, Reusability, and Simplicity received the most divergent opinions, which, according to our analysis, depend on the software-testing contexts. Also, we identified common challenges that apply to the important attributes, namely inadequate definition, lack of useful metrics, lack of an established review process, and lack of external support. The findings point out where practitioners actually need further support with respect to achieving high-quality test cases and test suites under different software testing contexts. Hence, the findings can serve as a guideline for academic researchers when looking for research directions on the topic. Furthermore, the findings can be used to encourage companies to provide more support to practitioners to achieve high-quality test cases and test suites.}, issn = {0963-9314} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_trbojevif_2025, title = {Quality of Journalism and Media Freedom in Europe : The fsQCA Approach}, author = {Trbojević, F. and Berglez, Peter and Vozab, D. and Ots, M. and Peruško, Z.}, year = {2025}, journal = {Central European Journal of Communication}, volume = {18}, number = {1}, pages = {29--50}, doi = {10.51480/1899-5101.18.1(39).686}, url = {2028301}, language = {eng}, publisher = {Polish Communication Association}, keywords = {democracy; europe; fsqca; journalism; media freedom}, abstract = {Media freedom is often seen as the main value against which the quality of media systems is judged. While the levels of media freedom in Europe are generally higher than the world average, there are yet significant variations in how certain European countries score on media freedom indices and scales. This paper uses comparative quantitative data and applies the fsQCA method to analyze how macro-, meso-, and micro-levels of journalism as a field relate to different levels of media freedom in Europe. The results suggest that media market structure, journalistic skills, and journalists adhering to the monitorial role of journalism constitute the “core” conditions for the implementation of media freedom.}, issn = {1899-5101} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_eklundpatrik_2025_1, title = {Quantales for Fuzzy Sets and Relations of Higher Types}, author = {Eklund, Patrik and Kortelainen, Jari and Löfstrand, Magnus}, year = {2025}, journal = {Mathematics}, volume = {13}, number = {13}, doi = {10.3390/math13132159}, url = {1980553}, language = {eng}, publisher = {MDPI}, keywords = {fuzzy set of higher type; fuzzy term; quantale; design structure}, abstract = {In this paper, we open up more possibilities to define higher types of fuzzy sets in a mixed way. In doing so, we show that there are essentially two alternative definitions for fuzzy sets of higher types, one of which is widely adopted in the literature, and one where the unit interval, or subsets thereof, is used to represent membership values. The other alternative definition opens up new perspectives for the use of fuzzy sets of higher types, and it promotes the use of other algebraic structures of sets of membership values, where quantales are seen as particularly useful, also in applications. The paper also underlines the importance of making distinctions between “computing with fuzzy” and “fuzzy computing” and understanding the difference between “logic with fuzzy” and “fuzzy logic”.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mockalexander_2025, title = {RadaRays : Real-Time Simulation of Rotating FMCW Radar for Mobile Robotics via Hardware-Accelerated Ray Tracing}, author = {Mock, Alexander and Magnusson, Martin and Hertzberg, Joachim}, year = {2025}, journal = {IEEE Robotics and Automation Letters}, volume = {10}, number = {3}, pages = {2470--2477}, doi = {10.1109/LRA.2025.3531689}, url = {1938002}, language = {eng}, publisher = {IEEE}, keywords = {radar; radar imaging; robots; spaceborne radar; ray tracing; meteorological radar; real-time systems; radar scattering; radar antennas; radar cross-sections; simulation and animation; range sensing; software tools for robot programming; slam; collision avoidance}, abstract = {RadaRays allows for the accurate modeling and simulation of rotating FMCW radar sensors in complex environments, including the simulation of reflection, refraction, and scattering of radar waves. Our software is able to handle large numbers of objects and materials in real-time, making it suitable for use in a variety of mobile robotics applications. We demonstrate the effectiveness of RadaRays through a series of experiments and show that it can more accurately reproduce the behavior of FMCW radar sensors in a variety of environments, compared to the ray casting-based lidar-like simulations that are commonly used in simulators for autonomous driving such as CARLA. Our experiments additionally serve as a valuable reference point for researchers to evaluate their own radar simulations. By using RadaRays, developers can significantly reduce the time and cost associated with prototyping and testing FMCW radar-based algorithms. We also provide a Gazebo plugin that makes our work accessible to the mobile robotics community.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_sandellklas_2025, title = {Radical friluftsliv and green transition : Argaladei’s 1970s as an inspiration for environmental education}, author = {Sandell, Klas and Öhman, Johan}, year = {2025}, number = {4}, url = {1955209}, language = {eng}, publisher = {ESERGO, Örebro universitet}, abstract = {The essay begins by highlighting some characteristics of the recurring discussions about the environmental educational possibilities of nature encounters. We situate this within the social climate of the 1970s with its discussion of alternatives to the prevailing model of development and where, among other things, deep ecological perspectives were important. Against this background, we then delve into a case study of the outdoor association Argaladei during the 1970s, with the motto "friluftsliv [outdoor life] is a lifestyle". Based on the association’s combination of social criticism, outdoor life and pedagogy, we highlight some central themes that we suggest offer possible inspiration for our current need for civic support for a green transition to more sustainable model of development.}, file = {https://oru.diva-portal.org/smash/get/diva2:1955209/FULLTEXT01.pdf} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_stabyolsnjohan_2025_3, title = {Radiotherapy of prostate cancer with aspects on hypofractionation and high precision}, author = {Staby Olsén, Johan}, year = {2025}, url = {1909332}, language = {eng}, publisher = {Örebro University}, keywords = {prostate cancer; radiation therapy; brachytherapy; high dose rate; hypofractionation}, abstract = {Hypofractionated radiotherapy (RT), including high dose rate brachy-therapy (HDR-BT) is a theoretically beneficial treatment option for curable prostate cancer. Our studies aimed to contribute to the growing body of results on the effectiveness and safety of HDR-BT both as monotherapy and as a boost in combination with external beam radiation therapy (EBRT).In paper I, 229 patients (low- and intermediate-risk) received 2 – 4 fractions of HDR-BT as monotherapy. The median follow-up time was 85 months. In total, 9.6% had a biochemical failure (BF) and severe toxicities were uncommon. The treatment was found to be effective and safe.In paper II, 355 patients (83% classified as high- or very high risk) received EBRT (3 Gy x 14) + a single fraction of HDR-BT (14.5 Gy). The median follow-up time was 56 months. The estimated five-year failure free survival was 79 % for the whole cohort. Our results suggest that this treatment appears to be feasible in terms of efficacy.In paper III, 34 patients who received EBRT + HDR-BT were randomized to either five or three fractions of EBRT per week. Intrafractional prostate movement was tracked in real-time using the Raypilot® system. The primary endpoint was patient-reported acute toxicity. We found no significant difference between the study groups. Target displacement was less than 2 mm during 97% of the time, supporting the use of small treatment margins.In paper IV, 175 patients received two fractions of HDR-BT (14 Gy x 2) as monotherapy. The estimated five-year cumulative BF rate was 3% for low-risk patients and 9.6% for intermediate-risk patients. The proportion of severe urinary and bowel toxicities were low, indicating that this treatment approach is effective and safe.}, file = {https://oru.diva-portal.org/smash/get/diva2:1909332/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_matikasalexios_2025, title = {Randomised trial of trastuzumab deruxtecan and biology-driven selection of neoadjuvant treatment for HER2-positive breast cancer : a study protocol of ARIADNE}, author = {Matikas, Alexios and Naume, Bjørn and Wildiers, Hans and Sonke, Gabe and Dieci, Maria Vittoria and Karakatsanis, Andreas and Andersson, Anne and Barnekow, Elin and Kessler, Luisa Edman and Einbeigi, Zakaria and Killander, Fredrika and Linderholm, Barbro and Schiza, Aglaia and Valachis, Antonis and Nearchou, Andreas and Engebraaten, Olav and Porojnicu, Alina and Soland, Mari Hiorth and Mannsåker, Bård and Raj, Sunil X. and Blix, Egil Støre and Nordstrand, Cecilie Soma and Lambertini, Matteo and Vernieri, Claudio and Punie, Kevin and Sotiriou, Christos and Bergh, Jonas and Villacampa, Guillermo and Zouzos, Athanasios and Hellström, Mats and Hartman, Johan and Foukakis, Theodoros}, year = {2025}, journal = {BMJ Open}, volume = {15}, number = {8}, doi = {10.1136/bmjopen-2025-102626}, url = {1992610}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {breast tumours; clinical trials; drug therapy}, abstract = {INTRODUCTION: Neoadjuvant therapy is the standard of care for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). Studies on first-generation antibody-drug conjugates, such as trastuzumab emtansine (T-DM1), showed equal or slightly lower efficacy than chemotherapy combined with dual HER2 blockade. Trastuzumab deruxtecan (T-DXd) is a next-generation conjugate approved for the treatment of metastatic HER2-positive and HER2-low BC, with greatly improved efficacy compared to T-DM1.METHODS AND ANALYSIS: ARIADNE is an academic, international, open-label, randomised, comparative phase IIB trial. A total of 370 patients with non-metastatic HER2-positive BC and an indication for neoadjuvant therapy will be included and randomised 1:1 to receive either (1) docetaxel (or paclitaxel), carboplatin, trastuzumab (H) and pertuzumab (P) for three cycles or (2) T-DXd for three cycles. Further treatment is based on the intrinsic molecular subtype determined by the Prosigna assay: patients with HER2-enriched disease (estimated 60%) continue the same treatment for three more cycles. Patients with oestrogen receptor (ER)-positive and luminal (estimated 30%) disease receive H and P for three cycles, combined with letrozole and ribociclib for two cycles. Patients with ER-negative and luminal, basal-like or normal-like disease (estimated 10%) either continue the same treatment for three more cycles in the case of a radiologic complete response, or, in the case of no complete response, they receive four cycles of dose-dense epirubicin and cyclophosphamide. The primary endpoint of ARIADNE is locally assessed rate of pathologic complete response in the molecularly HER2-enriched population, defined as ypT0/Tis, ypN0, as determined by a pathologist blinded to treatment assignment (intention-to-treat (ITT) analysis). Key secondary endpoints include time-to-event endpoints (event-free, recurrence-free, distant recurrence-free and overall survival), safety, health-related quality of life and translational studies.ETHICS AND DISSEMINATION: The study has been approved by the Swedish Medical Products Agency (Läkemedelsverket), the Swedish Ethical Review Authority (Etikprövningsmyndigheten) and the Norwegian Ethics Committee for Clinical Trials on Medicinal Products and Medical Devices, as well as by the review boards at all participating centres. Applications for ethical approval in Belgium, the Netherlands and Italy are ongoing. We intend to publish the results of the study in a scientific journal. The study results will be submitted to the European Union (EU) database within 1 year after the end of the clinical trial (CT).TRIAL REGISTRATION NUMBER: EU CT registration number: 2022-501504-95-00; ClinicalTrials.gov identifier: NCT05900206.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hijaziziad_2025, title = {Rationale and design of a registry-based randomized controlled study of personalized biomarker-based risk score-guided stroke prevention treatment in atrial fibrillation : Short title: The ABC AF-study design}, author = {Hijazi, Ziad and Wallentin, Lars and Arheden, Håkan and Björkenheim, Anna and Frykman, Viveka and Janzon, Magnus and Ravn-Fischer, Annica and Renlund, Henrik and Själander, Anders and Åkerfeldt, Torbjörn and Oldgren, Jonas}, year = {2025}, journal = {American Heart Journal}, volume = {290}, pages = {161--169}, doi = {10.1016/j.ahj.2025.06.011}, url = {1977431}, language = {eng}, publisher = {Elsevier}, keywords = {abc-af risk score; atrial fibrillation; biomarkers; oral anticoagulation; patient outcomes; randomized controlled study; stroke prevention}, abstract = {BACKGROUND: Stroke and reduced survival are devastating complications of atrial fibrillation (AF). Biomarker-based ABC-AF risk scores improve risk prediction in AF, and risk-guided treatment recommendations may improve patient outcomes.DESIGN: The ABC AF-study is a national, multicenter, prospective, registry-based, randomized controlled, parallel-group, open-label study. Its primary objective is to evaluate whether ABC-AF risk score-guided treatment recommendations improve outcomes in patients with AF. Consenting patients with AF registered in the Swedish national quality register for AF, AURICULA AF, will be randomized in a 1:1 ratio to either ABC-AF risk score-guided treatment recommendations or standard care. For participants in the active arm, investigators will receive a visual presentation of stroke and bleeding risks along with recommendations regarding the choice of oral anticoagulant (OAC) and additional treatments for stroke and bleeding prevention. In the control arm, patients are managed at the discretion of the investigator.OUTCOMES: The primary outcome is a composite of stroke or death. Secondary outcomes include the composite of stroke, death, and major bleeding, and the individual components of the primary outcome, myocardial infarction, and hospitalization for heart failure; and a safety endpoint of major bleeding. Study enrollment commenced on October 25, 2018, and terminated on May 12, 2023, after 3,933 patients had been recruited. Study results are expected in 2025.SUMMARY: The ABC AF-study evaluates whether a personalized treatment recommendation strategy - guided by the biomarker-based ABC-AF risk score decision support - improves outcomes in AF.}, issn = {0002-8703} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_strlmanlena_2025, title = {Reablement in residential aged care (Re-RAC) : A feasibility study}, author = {Strålman, Lena and Lidström-Holmqvist, Kajsa and Arvidsson Lindvall, M. and Philipson, Anna and Pettersson, C.}, year = {2025}, journal = {Scandinavian Journal of Occupational Therapy}, volume = {32}, number = {1}, doi = {10.1080/11038128.2025.2611541}, url = {2028520}, language = {eng}, publisher = {Pharma Intelligence UK Ltd.}, keywords = {activities of daily life; ageing; nursing home; older adults; well-being}, abstract = {BACKGROUND: Living in residential aged care (RAC) facilities can have a passivating effect on older adults. Reablement is an approach to increase activity and participation in daily life. However, research on reablement in RAC facilities remains limited, making further research necessary.AIMS/OBJECTIVES: This study aimed to investigate the feasibility of an 8-week reablement programme, Reablement in Residential Aged Care (Re-RAC), prior to a planned randomized controlled trial (RCT).MATERIAL AND METHODS: Re-RAC aligns with the Swedish RAC context and international reablement principles. Qualitative and quantitative data on occupational performance, physical activity, psychological well-being, quality of life, adherence, and residents' and staff experiences were collected at an RAC facility in Sweden. Descriptive statistics and content analysis were used.RESULTS: Six residents and 12 staff participated in the intervention. The methodology and intervention procedures were feasible overall. Participants requested more regular occupational therapy support, and staff requested support to motivate participants. CONCLUSIONS: This study demonstrates that Re-RAC was a feasible and well-accepted intervention in a Swedish RAC facility, although some areas for improvement were identified. Maintaining motivation was highlighted, and extended support will be incorporated.SIGNIFICANCE: This study provides practical guidance for reablement in RAC facilities, emphasizing resident motivation and staff engagement.}, issn = {1103-8128} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_philipsonanna_2025, title = {Reablement in Residential Aged Care (Re-RAC) : study protocol for a multi-center pragmatic randomized controlled open-label trial}, author = {Philipson, Anna and Arvidsson Lindvall, Mialinn and Pettersson, Cecilia and Strålman, Lena and Lidström-Holmqvist, Kajsa}, year = {2025}, journal = {Trials}, volume = {26}, number = {1}, doi = {10.1186/s13063-025-08999-0}, url = {1991284}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {aged; functional status; nursing homes; participation; patient-centered care; primary healthcare; psychological well-being; quality of life; rehabilitation}, abstract = {BACKGROUND: Living in residential aged care (RAC) facilities can be passivating and negatively impact residents' well-being and quality of life. With a growing global population of older adults and an increasing number residing in RAC facilities, it is crucial to address these concerns. Person-centered reablement, which enhances activity and participation through tailored, multidisciplinary strategies, has shown promising results in home settings. However, its implementation in RAC facilities, especially in Sweden, requires further evaluation. This research project will examine whether the reablement intervention in RAC (Re-RAC) impacts activity performance and satisfaction, participation, quality of life, and well-being, in older adults living in RAC facilities. Additionally, the project will evaluate the health-economic effects of the intervention and explore potential associations with the outcomes. A further aim is to describe the experiences of both the participating older adults and RAC facility staff involved in Re-RAC.METHODS: This is a multi-center prospective pragmatic randomized controlled trial has two parallel groups comparing the Re-RAC intervention with usual care. A total of 86 participants are planned to be enrolled. The 8-week intervention will be evaluated using quantitative, qualitative, and health-economic methods. Data will be collected at baseline and after the intervention. Health-economic data will also be gathered 3 months before and after intervention. Primary outcomes are activity performance and satisfaction with performance captured using the Canadian Occupational Performance Measure; secondary outcomes, i.e., health-related quality of life, psychological well-being, and physical activity levels will also be evaluated. Experiences of participants and staff will be captured through individual and focus-group interviews. Cost-effectiveness will be estimated by calculating the cost per quality-adjusted life year gained. Quantitative data will be analyzed using descriptive and comparative statistics; qualitative data will be analyzed using thematic analysis and focus-group methodology.DISCUSSION: This study evaluates the Re-RAC intervention for older adults in RAC through a real-world pragmatic trial, examining activity performance, satisfaction, quality of life, well-being, and health outcomes for older adults in RAC facilities. The study also explores participant and staff experiences and evaluates cost-effectiveness. The results will offer valuable insights informing the future implementation and assessment of reablement interventions in RAC settings.TRIAL REGISTRATION: ClinicalTrials.gov, ID: NCT06793501 . Registered on 20 January 2025.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kroonsa_2025_1, title = {Reality television dating with participants aged 65+ : constructing empowered older women and “less than” older men in Hotel Romance}, author = {Kroon, Åsa}, year = {2025}, journal = {Feminist Media Studies}, pages = {1--17}, doi = {10.1080/14680777.2025.2572714}, url = {2008143}, language = {eng}, publisher = {Routledge}, keywords = {empowerment; gender power dynamics; media constructions; older women; reality television dating shows}, abstract = {This paper presents a qualitative, reflexive thematic analysis of Season 2 of the Swedish reality television dating show Hotel Romance (2023–) featuring women and men between 65–85 years old. The analysis focuses on the constructed gender power dynamics between the women and men on the show which is generated through four sub-themes relating to gendered traits, looks, love and sexual stereotypes. The exposed gender power dynamics establishes older women as empowered and superior in relation to older men who do not appear to adhere to women’s standards and therefore come across as “less than” what women desire. Such a 65+ gender power dynamics contrasts with existing research of gender representations in reality television dating shows featuring younger participants where sexism and patriarchal values are routinely reproduced. The result also clashes with research of images of older women in the media which expose systematic devaluations of this group. Finally, insights into the production of the show suggest that, along with conveying a successful ageing discourse, Hotel Romance implicitly positions older people of both genders as Others to be looked at by 30-something audiences who are assumed to dread the loss of love, sex and romance after the age of 65. }, issn = {1468-0777}, file = {https://oru.diva-portal.org/smash/get/diva2:2008143/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kronsellalexander_2025, title = {Real-world analysis of pharmacological treatments to prevent relapse after electroconvulsive therapy for major depressive disorder : A nationwide cohort study}, author = {Kronsell, Alexander and Nordenskjöld, Axel and Bodén, Robert and Mittendorfer-Rutz, Ellenor and Reutfors, Johan and Rossides, Marios and Tiger, Mikael}, year = {2025}, journal = {Translational Psychiatry}, volume = {15}, number = {1}, doi = {10.1038/s41398-025-03746-0}, url = {2016187}, language = {eng}, publisher = {Springer Nature}, abstract = {During the first year following electroconvulsive therapy (ECT) for major depressive disorder (MDD) there is a large risk of relapse. Previous studies have shown favourable results for lithium after ECT for MDD. However, lithium is infrequently prescribed after ECT. While some evidence exists for other pharmacological strategies such as TCAs and TCA-lithium combinations, comparative data remain limited. The aim of this study was to explore pharmacological treatments after ECT for MDD and analyse their association with relapse following response to ECT for MDD. We hypothesized that lithium would be associated with a lower risk of relapse. We conducted a nationwide cohort study using data from Swedish registers. Patients 18 years or older with MDD who received ECT 2013-2019 and responded distinctly to ECT were followed for a year. Specified drugs dispensed up to four weeks after the ECT series were considered the exposure. Relapse was defined as psychiatric hospitalisation, renewed ECT, intentional self-harm, or death by suicide. Adjusted hazard ratios (aHR) and 95% confidence intervals (CI) were estimated using Cox models controlled for several potential confounders. The study population included 2 858 patients with distinct response to ECT. The most common psychiatric drugs dispensed after ECT were antipsychotics (39.7%), mirtazapine (38.0%), and selective serotonin reuptake inhibitors (SSRI) (35.9%). There was a statistically non-significant lower risk of relapse associated with lithium (aHR 0.86, 95% CI 0.69-1.07, p = 0.17). Antipsychotics were associated with a greater risk of relapse (aHR 1.17, 95% CI 1.05-1.31, p = 0.006). For other pharmacological treatments there were no associations with risk of relapse.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rochenicolas_2025, title = {Real-world occurrence of cardiopulmonary events among patients with COPD : the ABACOS-OUTCOMES Study (US)}, author = {Roche, Nicolas and Tkacz, Joseph and Wilson, Kathleen and Johnson, William and Sundh, Josefin and Martinez, Fernando and Chen, Hungta and Varghese, Della and Dods, Stephanie and Mullerova, Hana and Germack, Hayley D. and Berg, David and Hui, Christopher and Pollack, Michael}, year = {2025}, journal = {European Respiratory Journal}, volume = {66}, number = {Suppl. 69}, doi = {10.1183/13993003.congress-2025.PA4544}, url = {2038936}, language = {eng}, publisher = {European Respiratory Society}, abstract = {Recent studies have established an association between COPD exacerbations and cardiopulmonary risk. However, the general burden of cardiopulmonary events remains poorly characterized among COPD patients; further investigation is needed to understand underlying risks and event rates.This study used the Inovalon More2 Registry® and Medicare Fee-for-Service (MFFS) claims data. Patients identified between 1/1/20‒12/31/22 were ≥40 yrs and had: ≥2 Dx for COPD, ≥12-mos history and ≥1 day follow-up post index date (1st COPD diagnosis). Outcomes were incidence rates of cardiopulmonary events stratified by sub-groups. Cardiopulmonary events included hospitalizations for COPD exacerbations and cardiovascular (CV) events. Rates are presented separately for severe COPD exacerbations and CV events.2.08M patients with COPD were identified: mean age 72 yrs, 57% female, 70% MFFS, and 31.4% low-income. Overall, incidence of cardiopulmonary events was 19.64 per 100-PYs (95%CI:19.59‒19.68); ranging between 13.24 (13.15‒13.34) for newly diagnosed COPD patients to 49.75 (49.60‒49.90) for patients with baseline heart failure (Table). Overall, the incidence of severe exacerbations and CV events was 7.64 (7.61‒7.67) and 12.00 (11.94‒12.05), respectively.Among patients with COPD, real-world incidence of cardiopulmonary events was highest among those with baseline heart failure; even newly diagnosed patients with COPD experienced events.}, issn = {0903-1936} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_abuishkheidemimadeddin_2025, title = {Real-world outcomes of aflibercept 8 mg in patients previously treated for neovascular age-related macular degeneration}, author = {Abu Ishkheidem, Imadeddin and Inci, Esra and Breimer, Martin and Silfverswärd, Sofia Töyrä and Zetterberg, Madeleine and Andersson Grönlund, Marita}, year = {2025}, journal = {Acta Ophthalmologica}, doi = {10.1111/aos.17590}, url = {1996390}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {aflibercept; age‐related macular degeneration; ocular inflammation; optical coherence tomography; real‐world data}, abstract = {PURPOSE: To evaluate visual, anatomical and safety outcomes of aflibercept 8 mg in previously treated patients with neovascular age-related macular degeneration (nAMD).METHODS: This retrospective study included nAMD patients switched to aflibercept 8 mg from prior anti-VEGF therapies at Sahlgrenska University Hospital between February 2024 and February 2025. Data on best-corrected visual acuity (BCVA), central retinal thickness (CRT), pigment epithelial detachment (PED) height, fluid status, treatment intervals, time to fluid recurrence and adverse events were collected.RESULTS: 181 eyes (167 patients; mean age 80.4 ± 8.5 years; 67.7% female) were included, with a median follow-up of 12.9 weeks (range 4.1-48.1). A total of 415 injections were administered (mean 2.1 ± 1.5 per eye). BCVA remained stable (baseline 0.46 ± 0.31 logMAR; post-treatment 0.47 ± 0.37 logMAR; p = 0.18). CRT decreased significantly (-19.5 ± 47.2 μm; p < 0.001), as did PED height (-37.4 ± 68.4 μm; p < 0.001). Intraretinal fluid prevalence decreased from 34.3% to 19.3% (p < 0.001) and subretinal fluid from 53.0% to 33.7% (p < 0.001). The median maximal dry interval achieved was nine weeks, and analysis of interval extension showed a statistically significant mean increase of 1.27 ± 4.24 weeks overall (p = 0.0009), particularly in eyes dry at baseline. The median time to fluid recurrence among those with reactivation was ten weeks. Higher baseline CRT predicted greater CRT reduction (-44.1 μm per 100 μm increase; p < 0.001) but shorter dry intervals. Safety was favourable, with one case (0.6% per eye; 0.2% per injection) of mild anterior uveitis and no cases of intraocular pressure elevation.CONCLUSIONS: Switching to aflibercept 8 mg led to stable vision, significant anatomical improvements, extended treatment intervals and a favourable short-term safety profile. Longer follow-up is warranted.}, issn = {1755-375X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_inanelnaggarali_2025, title = {Real-world survival outcomes of neoadjuvant versus adjuvant chemotherapy in operable triple-negative breast cancer : a propensity score matched registry-based study}, author = {Inan El-Naggar, Ali and Karakatsanis, Andreas and Valachis, Antonis}, year = {2025}, journal = {Acta Oncologica}, volume = {64}, pages = {1334--1341}, doi = {10.2340/1651-226X.2025.43990}, url = {2003111}, language = {eng}, publisher = {MJS Publishing}, keywords = {triple negative breast neoplasms; neoadjuvant therapy; adjuvant chemotherapy; treatment outcome}, abstract = {BACKGROUND AND PURPOSE: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype where the prognostic implications of primary systemic therapy followed by surgery, compared to up-front surgery and subsequent adjuvant chemotherapy (ACT), are yet to be outlined. This retrospective registry-based study aimed to compare survival outcomes between patients treated with neoadjuvant chemotherapy (NACT) versus ACT for operable TNBC in a real-world setting.Patient/material and methods: We included all patients treated with chemotherapy for operable TNBC in Sweden between 2008 and 2019 using the Swedish national research database BCBaSe 3.0. To reduce confounding by indication, we implemented propensity score matching (PSM) and main study outcomes were defined as distant disease-free survival (DDFS), breast cancer-specific survival (BCSS) and overall survival (OS).RESULTS: A total of 4,704 patients were included in the study, of which 1,183 received NACT. Following 1:1 PSM, 837 patients in each treatment setting were available for analyses. We found no statistically significant differences in terms of DDFS (adjusted hazard ratio [aHR] 1.18; 95% confidence interval [CI] 0.93 - 1.50), BCSS (aHR 1.10; 95% CI 0.83 - 1.45) or OS (aHR 1.07; 95% CI 0.82 - 1.39) between patients treated with NACT versus ACT. However, subgroup analysis of patients with clinically node-positive disease (cN+) demonstrated a significant DDFS benefit of NACT (aHR 0.65; 95% CI 0.47 - 0.90).INTERPRETATION: Overall, we found comparable survival among patients with TNBC treated with NACT or ACT. Considering the anticipated survival improvements when response-guided post-neoadjuvant strategies are implemented in clinical practice, our findings may support the use of NACT in operable TNBC.}, issn = {0284-186X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_isacssonalexander_2025_4, title = {Recension av: Hedvig Eleonora och hennes tid}, author = {Isacsson, Alexander}, year = {2025}, journal = {Historisk Tidskrift}, volume = {145}, number = {1}, pages = {139--140}, url = {1938982}, language = {swe}, publisher = {Svenska historiska föreningen}, issn = {0345-469X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jonasdottirannag_2025, title = {Recension av: Illouz, Eva, 2024. Känslor och populism : Hur rädsla, äckel, förbittring och kärlek undergräver demokratin}, author = {Jonasdottir, Anna G.}, year = {2025}, journal = {Statsvetenskaplig Tidskrift}, volume = {127}, number = {2}, pages = {427--435}, url = {1994448}, language = {swe}, publisher = {Fahlbeckska stiftelsen}, issn = {0039-0747} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dahlizabelaa_2025_5, title = {Recension av: Oscar Österberg (red.), Någonstans i Sverige: En antologi med lokalhistoriska perspektiv på Sverige och Förintelsen (Stockholm: Forum för levande historia 2023). 289 s.}, author = {Dahl, Izabela A.}, year = {2025}, journal = {Historisk Tidskrift}, number = {1}, pages = {161--164}, url = {1941749}, language = {swe}, keywords = {förintelsen och sverige; lokalhistoriska perspektiv}, issn = {0345-469X} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_mazurstepan_2025_2, title = {Recent Developments in Bayesian Econometrics and Their Applications : Festschrift in Honour of Sune Karlsson}, author = {Mazur, Stepan and Österholm, Pär}, year = {2025}, doi = {10.1007/978-3-032-00110-8}, url = {2012563}, language = {eng}, publisher = {Springer}, abstract = {The original contributions on Bayesian econometrics gathered in this book pay tribute to Sune Karlsson, celebrating his significant work in time series econometrics and its applications in macroeconomics and finance. The volume consists of both methodological and empirical studies by leading experts in the field, with particular attention paid to Bayesian vector autoregressive (VAR) models and forecasting. It addresses forecasting with Bayesian VARs as a research field, mixed-frequency and high-dimensional Bayesian VARs, various forms of Bayesian VARs with stochastic volatility, forecast combination, analysis of time-varying parameter models in the frequency domain, and portfolio analysis in a Bayesian framework. Presenting cutting-edge research and providing valuable insights into the field of Bayesian econometrics, the book will appeal to researchers, practitioners in the banking sector, and government authorities.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_freckmannguido_2025, title = {Recommendations on the Collection of Comparator Measurement Data in the Performance Evaluation of Continuous Glucose Monitoring Systems}, author = {Freckmann, Guido and Pleus, Stefan and Eichenlaub, Manuel and Eriksson Boija, Elisabet and Fokkert, Marion and Hinzmann, Rolf and Jendle, Johan and Klonoff, David C. and Makris, Konstantinos and Nichols, James H. and Pemberton, John and Selvin, Elizabeth and Tran, Nam K. and Witthauer, Lilian and Slingerland, Robbert J.}, year = {2025}, journal = {Journal of Diabetes Science and Technology}, volume = {19}, number = {4}, pages = {1072--1081}, doi = {10.1177/19322968251336221}, url = {1956516}, language = {eng}, publisher = {Diabetes Technology Society}, keywords = {clinical performance evaluation; comparator data requirements; continuous glucose monitoring; standardization; traceability}, abstract = {While current systems for continuous glucose monitoring (CGM) are safe and effective, there is a high degree of variability between readings within and across CGM systems. In current CGM performance studies, device readings are compared with glucose concentrations obtained with a comparator ("reference") measurement procedure (usually capillary or venous glucose). However, glucose concentrations from capillary and venous samples can systematically differ, often by as much as 5 to 10%. Different comparator methods have shown biases of up to 8%, and comparator devices of the same brand can systematically differ by more than 5%. To address these issues, the Working Group on CGM of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC WG-CGM) recommends standardizing study procedures and the comparator measurement process in CGM performance studies. The majority of IFCC WG-CGM members recommend the use of capillary samples as reference, mainly because CGM readings will then be aligned better with results from self-monitoring of blood glucose (SMBG). Even with factory-calibrated CGM systems, manufacturers require CGM users to perform SMBG in some situations, eg, manual calibration, confirmation of extreme readings, discordance between CGM readings and symptoms of hyper- or hypoglycemia, or intermittent signal loss. Comparator devices should meet defined analytical performance specifications for bias and imprecision. Comparator bias can be reduced by retrospective correction of comparator values based on measurements with a method or materials of higher metrological order. Once manufacturers align CGM readings of their systems with comparator results using standardized procedures, variability across CGM systems will be reduced.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_freckmannguido_2025_1, title = {Recommendations on the Collection of Comparator Measurement Data in the Performance Evaluation of Continuous Glucose Monitoring Systems}, author = {Freckmann, Guido and Pleus, Stefan and Eichenlaub, Manuel and Boija, Elisabet Eriksson and Fokkert, Marion and Hinzmann, Rolf and Jendle, Johan and Klonoff, David C. and Makris, Konstantinos and Nichols, James H. and Pemberton, John and Selvin, Elizabeth and Tran, Nam K. and Witthauer, Lilian and Slingerland, Robbert J.}, year = {2025}, journal = {EJIFCC}, volume = {36}, number = {3}, pages = {225--235}, doi = {10.1177/19322968251336221}, url = {2007129}, language = {eng}, publisher = {International Federation of Clinical Chemistry and Laboratory Medicine}, keywords = {clinical performance evaluation; comparator data requirements; continuous glucose monitoring; standardization; traceability}, abstract = {While current systems for continuous glucose monitoring (CGM) are safe and effective, there is a high degree of variability between readings within and across CGM systems. In current CGM performance studies, device readings are compared to glucose concentrations obtained with a comparator ("reference") measurement procedure (usually capillary or venous glucose). However, glucose concentrations from capillary and venous samples can systematically differ, often by as much as 5 to 10%. Different comparator methods have shown biases of up to 8%, and comparator devices of the same brand can systematically differ by more than 5%. To address these issues, the Working Group on CGM of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC WG-CGM) recommends standardizing study procedures and the comparator measurement process in CGM performance studies. The majority of IFCC WG-CGM members recommend the use of capillary samples as reference, mainly because CGM readings will then be aligned better with results from self-monitoring of blood glucose (SMBG). Even with factory-calibrated CGM systems, manufacturers require CGM users to perform SMBG in some situations, e.g., manual calibration, confirmation of extreme readings, discordance between CGM readings and symptoms of hyper- or hypoglycemia, or intermittent signal loss. Comparator devices should meet defined analytical performance specifications for bias and imprecision. Comparator bias can be reduced by retrospective correction of comparator values based on measurements with a method or materials of higher metrological order. Once manufacturers align CGM readings of their systems with comparator results using standardized procedures, variability across CGM systems will be reduced.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_marquardtjens_2025, title = {Reconciling democracy and sustainability : three political challenges and the role of democratic innovations}, author = {Marquardt, Jens and Pfeiffer, Frederik and Blum, Mareike and Daw, Tim M. and Dugasseh, Frank Akowuge and Heitzig, Jobst and Hysing, Erik and Jensen, Ingrid Helene Brandt and Kulha, Katariina and Langkjær, Frederik and Lindvall, Daniel and Nasiritousi, Naghmeh and Schlosberg, David and Toikka, Arho and Tønder, Lars}, year = {2025}, journal = {Sustainability: Science, Practice, & Policy}, volume = {21}, number = {1}, doi = {10.1080/15487733.2025.2504239}, url = {1963046}, language = {eng}, publisher = {Taylor & Francis Group}, keywords = {climate change; democracy; participation; transformation; politicization; imaginaries}, abstract = {Governing sustainability challenges such as climate change or biodiversity loss presents a profound democratic dilemma. Although democratic practices and procedures are widely regarded as essential for collectively addressing complex sustainability issues, liberal democracies have been criticized by some scholars for their inability to effectively tackle global environmental threats like climate change. We reconcile these positions by outlining how the emerging field of democratic innovations can help to address the critical challenges that democracies face when governing sustainability transformations. We focus on three issues liberal democracies are confronted with: reformist incrementalism, (de)politicization, and imaginary boundaries. We then exemplify how democratic innovations such as deliberative mini-publics, participatory budgeting, and material participation can help address these challenges. Our review suggests that democratic innovations hold the potential to address political concerns, find compromises between extreme positions, reconnect people's everyday lives with the grand sustainability challenges they face, and allow for alternative visions of a desirable future society. However, we also address cautionary tales, discuss the limitations of democratic innovations, and outline avenues for future research, which we believe can help further elaborate and develop participatory approaches to critical sustainability challenges.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_anderssonhelen_2025, title = {Recontextualizing a healthy lifestyle through interface design : A Multimodal Critical Discourse Analysis of the Lifesum app}, author = {Andersson, Helen}, year = {2025}, journal = {Discourse, Context & Media}, volume = {64}, doi = {10.1016/j.dcm.2025.100863}, url = {1932930}, language = {eng}, publisher = {Elsevier}, keywords = {calorie-tracking apps; interface design; multimodality; affordances; healthy eating; neoliberalism}, abstract = {Self-tracking technologies have created new conditions for self-management and self-control. Research has shown how these technologies and their design are shaped by ideological assumptions and norms, particularly in their interactions with users. However, less attention has been given to the interplay between interface design, user interaction, and meaning making, especially in the context of food and health. This article uses multimodal critical discourse analysis to explore how the interface design of a commercial calorie-tracking app, along with the actions it enables, constructs and reinforces health and healthy eating as scientific practices. It also highlights how healthy eating is framed as something the user must choose, control, adapt, take responsibility for, and improve. Through interface design choices, commercial actors can sustain and reproduce ideas and ideologies linked to nutritionism, wellness and neoliberalism, while simultaneously benefiting from them.}, issn = {2211-6958} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_holmsebastian_2025_3, title = {Recreational Use of Nitrous Oxide as a Source of Frostbite Injuries to the Skin : A Review of the Literature and a Case Report}, author = {Holm, Sebastian and Tabrisi, Reza and Zdolsek, Johann}, year = {2025}, journal = {European Burn Journal}, volume = {6}, number = {1}, doi = {10.3390/ebj6010014}, url = {1947952}, language = {eng}, publisher = {MDPI}, keywords = {frostbite injuries; frostbites; laughing gas; nitrous oxide}, abstract = {Nitrous oxide has a wide range of medical applications, such as being used as an analgesic in general anesthesia, dental procedures, childbirth and sedation. Lately, it has also been employed as an inhalant recreational drug to induce brief euphoria. Recent studies indicate a worldwide rise in the incidence of skin frostbites associated with nitrous oxide use. A scoping review was conducted to synthesize and summarize the existing literature published in English regarding frostbite injuries associated with the recreational use of nitrous oxide. The literature search was carried out in July 2024 using databases such as Embase, Web of Science and PubMed®. From an initial pool of 83 publications, 8 studies were ultimately selected for full-text review as they met our inclusion criteria for analysis. Additionally, we provide a representative clinical case involving a 21-year-old male who experienced frostbite following skin exposure to nitrous oxide. Most publications on nitrous oxide induced frostbites are from recent years, primarily between 2022 and 2024, with the first case documented in 1996. These injuries are mostly observed in young adults, with a female dominance, and are typically localized to the inner thighs. According to the existing literature, the predominant treatment approach is conservative management, with excision and split-thickness skin grafting (STSG) in the second place. This study represents the first literature review summarizing frostbite injuries to the skin from nitrous oxide misuse. There is a need for enhanced preventive measures to raise public awareness and reduce the incidence of frostbite injuries associated with the recreational use of nitrous oxide.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rutegrdmartin_2025_2, title = {Rectal Cancer Surgery Can Be Tailored To Reduce Morbidity}, author = {Rutegård, Martin and Segelman, Josefin and Matthiessen, Peter and Lydrup, Marie-Louise and Park, Jennifer}, year = {2025}, journal = {Diseases of the Colon & Rectum}, volume = {68}, number = {4}, doi = {10.1097/DCR.0000000000003638}, url = {1926052}, language = {eng}, publisher = {Springer}, issn = {0012-3706} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ballesterdolzpablo_2025_2, title = {Recurrence of solitary extramedullary plasmacytoma affecting both optic nerves : a case report}, author = {Ballester Dolz, Pablo and Gkretsis, Dimitrios and Andersson Grönlund, Marita}, year = {2025}, journal = {American journal of ophthalmology case reports}, volume = {40}, doi = {10.1016/j.ajoc.2025.102438}, url = {2006637}, language = {eng}, publisher = {Elsevier}, keywords = {multiple myeloma; optic nerve edema; plasmacytoma}, abstract = {PURPOSE: To present a case of atypically located plasmacytoma recurrence with bilateral involvement of the optic nerves.OBSERVATIONS: A 73-year-old man with diabetes, essential hypertension, and primary hypercholesterolemia presented to our clinic with subjective visual loss in his left eye. The patient had a previous history of solitary extramedullary plasmacytoma in the spinal cord, which was treated with resection surgery at the thoracic T6-T12 levels and curative radiotherapy two years prior. The ophthalmological examination indicated best-corrected visual acuity of 20/50 (0.4 logMAR) in both the right eye (OD) and left eye (OS). Intraocular pressure was normal and fundus examination of the eyes showed edema in the left optic nerve, but no other findings. Magnetic resonance imaging of the brain and orbits showed enhancement in both optic nerves, as in other parts of the central nervous system (CNS).CONCLUSIONS AND IMPORTANCE: Plasmacytoma represents a rare form of plasma cell neoplasm. When the condition progresses and affects different sites within the CNS, it is essential to re-evaluate and exclude progression to multiple myeloma and/or other plasma cell neoplasms. Individuals diagnosed with plasmacytoma who complain of visual disturbances should undergo ophthalmologic evaluation.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_golovchanovanadezhda_2025, title = {Recurrent pain in older age : A cross-sectional network analysis of biopsychosocial-existential interactions}, author = {Golovchanova, Nadezhda and Zhao, Xiang and Flink, Ida and Owiredua, Christiana and Boersma, Katja}, year = {2025}, journal = {Journal of Psychosomatic Research}, volume = {189}, doi = {10.1016/j.jpsychores.2024.112016}, url = {1922796}, language = {eng}, publisher = {Elsevier}, keywords = {chronic pain; pain interference; older adults; biopsychosocial model; existential domain; network analysis}, abstract = {Objective: Chronic pain is a prevalent condition in older adults, associated with substantial distress. For many older people, chronic pain interferes with their daily life which is reflected in various life domains. This study aimed to investigate whether interactions among self-reported indicators of biological, psychological, social, and existential life domains differ for older adults with no pain, with non-interfering pain, and with interfering pain.Method: The study was based on the cross-sectional 65+ and Safe Study data (N = 622; age range 64–106 years; 60.6 % women). Network analysis was used to assess the inter-variable associations for older adults reporting no pain, non-interfering pain, and interfering pain separately. Network visualization and centrality tests were performed. Permutation-based analyses were conducted to investigate the connections among variables in three subgroups.Results: We identified a structural difference between the networks of older adults with no pain and interfering pain, suggesting differences in connectivity among the life domains. The strength centrality metrics showed the central role of presence of meaning in the networks of older adults with no pain and with non-interfering pain, while for older adults with interfering pain, anxiety appeared to be dominant.Conclusion: The findings illuminated that anxiety regulation and meaning-enhancement are potentially important intervention targets for older adults with recurrent pain. Overall, the study highlighted the value of a holistic biopsychosocial-existential approach for understanding and managing pain in older adults.}, issn = {0022-3999} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_keesomels_2025, title = {Reducing phantom limb pain using phantom motor execution enabled by augmented and virtual reality : participants' perspectives on an innovative treatment}, author = {Keesom, Els and Lidström-Holmqvist, Kajsa and Ortiz-Catalan, Max and Pilch, Monika and Lendaro, Eva and Hermansson, Liselotte and van der Sluis, Corry K.}, year = {2025}, journal = {Disability and Rehabilitation}, volume = {47}, number = {12}, pages = {3078--3087}, doi = {10.1080/09638288.2024.2413179}, url = {1905989}, language = {eng}, publisher = {Taylor & Francis}, keywords = {pain management; activities of daily living; qualitative research; social participation; therapeutic approach}, abstract = {PURPOSE: Phantom limb pain (PLP) is a condition that greatly diminishes quality of life. Phantom motor execution (PME), enabled by myoelectric pattern recognition combined with virtual and augmented reality, is a novel treatment for PLP. Here we, aimed to describe patients' experiences of this treatment.MATERIAL AND METHODS: Qualitative, using semi-structured interviews one month after completed PME treatment. Twenty-one Swedish and Dutch patients (mean age 57, 16 males, 16 lower limb amputations) participated. The analysis followed the framework approach.RESULTS: The main themes were 1) treatment effects on the perception of the phantom limb, 2) living with PLP before and after treatment, and 3) facilitators and barriers to treatment. Most participants learned to control their phantom limb, perceived it more positively and as more complete. This control over the phantom limb became a tool for managing PLP. Most participants' outlook on life and energy levels improved after treatment. Being mentally focused during treatment was important. Therapists were pivotal to the success of the treatment.CONCLUSION: Controlling the phantom limb improved their perception of it and pain management, self-agency, and quality of life. The therapists' role was invaluable. We suggest training for patients in phantom limb control before and after amputation.}, issn = {0963-8288} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_georgiihemmingeva_2025, title = {Reforming Teacher Education : Simplifying a Complex Profession}, author = {Georgii-Hemming, Eva and Moberg, Nadia}, year = {2025}, url = {1996855}, language = {eng}, abstract = {This paper examines the public debate on teacher education in Sweden over the past two decades and its impact on current reforms. Drawing on policy documents, media discussions, and scholarly perspectives, we show how teacher education has become the most frequently reformed part of higher education, shaped largely by political agendas and external voices rather than research-based knowledge. The debate often blames pedagogy for perceived failures, favors cognitive science and psychology over educational research, and downplays critical thinking and reflection. We conclude by highlighting concerns about this development, while pointing to how alternative paths for music teacher education may emerge through questioning and challenging neoliberal logics.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_jonssonjessica_2025_5, title = {Refraiming Reparations}, author = {Jonsson, Jessica}, year = {2025}, url = {1998594}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_munoznovoamaria_2025, title = {Regaining the intention to live after relief of intractable phantom limb pain : A case study}, author = {Munoz-Novoa, Maria and van Veldhoven, Joanna Ewf and Postema, Sietke G. and Kristoffersen, Morten B. and Keesom, Els and Lendaro, Eva and Lidström-Holmqvist, Kajsa and Ortiz-Catalan, Max and van der Sluis, Corry K.}, year = {2025}, journal = {Scandinavian Journal of Pain}, volume = {25}, number = {1}, doi = {10.1515/sjpain-2025-0006}, url = {1975342}, language = {eng}, publisher = {Walter de Gruyter}, keywords = {amputee; euthanasia; phantom limb pain; phantom motor imagery; virtual reality}, abstract = {OBJECTIVES: Phantom limb pain (PLP) is common after limb amputation and can lead to chronic pain and psychosocial risks, potentially leading to suicide or euthanasia. This study aimed to explore the consequences of intractable PLP on a person's life before, during, and after receiving phantom motor imagery (PMI) treatment, focusing on the person's experiences with PMI and how it influenced his life and decision regarding euthanasia.METHODS: This case study focused on a single participant from the PMI treatment group of a PLP randomized clinical trial (RCT). The participant, who joined the RCT as a last resort before euthanasia, experienced decreased PLP during the trial, but the pain returned 1 month post-treatment. Subsequently, the participant initiated self-administered PMI training at home. A mixed quantitative-qualitative method approach was used to analyze this case study.RESULTS: Understanding and living with PLP was challenging for the participant, making him lose interest in life. Despite starting with low expectations, the participant enjoyed PMI, particularly home training. PLP disappeared during the RCT, returned after therapy cessation, and vanished again during PMI home training. PMI returned his motivation to live, leading him to discontinue his plans for euthanasia.CONCLUSIONS: This case illustrates the severity of chronic PLP, highlighting also the complex interaction of biopsychosocial factors in pain, which can lead a person to consider euthanasia. Representing the first use of PMI in a home setting, this study, along with previous studies in clinical setting, indicates PMI to be a promising and feasible innovative intervention for decreasing PLP, encouraging further research. This study also emphasizes the need to enhance PLP education among clinicians and people with amputations.}, issn = {1877-8860} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_25, title = {Regler för verksamhetsöverlåtelse är inte i strid med EU-rätten}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031693}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 24 april 2025 kom Högsta förvaltningsdomstolens dom i mål nr 507-25 om veksamhetsöverlåtelse i mervärdesskattesammanhang. Eleonor Kristoffersson, professor i skatterätt, analyserar domen.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jnssonmarie_2025, title = {Rehabilitation interventions at senior day centres for older adults : a scoping review}, author = {Jönsson, Marie and Pettersson, Cecilia and Lindvall, Mialinn Arvidsson}, year = {2025}, journal = {Frontiers in Public Health}, volume = {13}, doi = {10.3389/fpubh.2025.1659493}, url = {2023142}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {day care; interventions; elderly; professions; tools}, abstract = {Background: There is ample evidence that senior day centres can provide rehabilitation, increase activity and support social participation for older adults.Aim: The aim of this scoping review is to provide an overview of the scientific literature in this field and investigate whether there is scientific evidence for the efficacy of rehabilitation interventions at senior day centres for older adults.Methods: The scoping review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Data were collected from databases between January 2010 and December 2020 and updated December 2023. The scoping review was conducted in the databases CINAHL, Cochrane Library and PubMed and 29 articles were identified for inclusion.Results: Rehabilitation interventions at the senior day centres varied considerably. The main findings concern interventions of a physical, cognitive and/or social character. The most common dimensions of outcome were improvements in physical and cognitive ability and quality of life. There was also considerable variation in the professionals involved. Other important factors to observe when participating in interventions at senior day centres could be loneliness and risk of falls.Conclusion: While rehabilitation interventions at senior day centres are striving towards person-centred care, there is room for improvement to meet older adults' individual needs. In conclusion, this scoping review shows that greater focus is needed to strengthen the evidence base for examine interventions that are most effective in these settings.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_desmetlennert_2025, title = {Relational Neurosymbolic Markov Models}, author = {De Smet, Lennert and Venturato, Gabriele and De Raedt, Luc and Marra, Giuseppe}, year = {2025}, volume = {39:15}, pages = {16181--16189}, doi = {10.1609/aaai.v39i15.33777}, url = {1986224}, language = {eng}, publisher = {AAAI Press}, abstract = {Sequential problems are ubiquitous in AI, such as in reinforcement learning or natural language processing. State-of-the-art deep sequential models, like transformers, excel in these settings but fail to guarantee the satisfaction of constraints necessary for trustworthy deployment. In contrast, neurosymbolic AI (NeSy) provides a sound formalism to enforce constraints in deep probabilistic models but scales exponentially on sequential problems. To overcome these limitations, we introduce relational neurosymbolic Markov models (NeSy-MMs), a new class of end-to-end differentiable sequential models that integrate and provably satisfy relational logical constraints. We propose a strategy for inference and learning that scales on sequential settings, and that combines approximate Bayesian inference, automated reasoning, and gradient estimation. Our experiments show that NeSy-MMs can solve problems beyond the current state-of-the-art in neurosymbolic AI and still provide strong guarantees with respect to desired properties. Moreover, we show that our models are more interpretable and that constraints can be adapted at test time to out-of-distribution scenarios.Code - https://github.com/ML-KULeuven/nesy-mmExtended version - https://arxiv.org/abs/2412.13023} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_frbertole_2025, title = {Relationships of hsCRP to High-Risk Vulnerable Plaque After NSTEMI : Insights From the PROSPECT II Trial}, author = {Fröbert, Ole and Stone, Gregg W. and Larsen, Alf Inge and Zhou, Zhipeng and Kotinkaduwa, Lak N. and Engstrøm, Thomas and Kjøller-Hansen, Lars and Maeng, Michael and Matsumura, Mitsuaki and Ben-Yehuda, Ori and Bøtker, Hans Erik and Persson, Jonas and Wiseth, Rune and Jensen, Lisette O. and Nordrehaug, Jan E. and Trovik, Thor and Jensen, Ulf and Bleie, Øyvind and James, Stefan K. and Ali, Ziad A. and Omerovic, Elmir and Erlinge, David and Maehara, Akiko}, year = {2025}, journal = {JACC: Cardiovascular Interventions}, volume = {18}, number = {10}, pages = {1217--1228}, doi = {10.1016/j.jcin.2025.01.440}, url = {1954870}, language = {eng}, publisher = {Elsevier}, keywords = {atherosclerosis; cardiovascular event(s); coronary plaques; inflammation; intravascular ultrasound; myocardial infarction; near-infrared spectroscopy; non–st-segment elevation myocardial infarction}, abstract = {BACKGROUND: Inflammation is a driver of atherosclerosis and susceptibility to cardiovascular events. OBJECTIVES: The authors sought to evaluate whether high-sensitivity C-reactive protein (hsCRP) levels are associated with the prevalence of high-risk coronary plaques in patients with non-ST-segment elevation myocardial infarction (NSTEMI).METHODS: PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree) II was a multicenter, prospective study enrolling patients with recent myocardial infarction. Following treatment of all flow-limiting lesions, 3-vessel imaging with near-infrared spectroscopy and intravascular ultrasound was used to characterize untreated nonculprit lesions. We investigated the association between baseline hsCRP and plaque morphology (lipid content, plaque burden, lumen area) in 501 NSTEMI patients. hsCRP levels were categorized as low (<1 mg/L), intermediate (1-3 mg/L), or high (>3 mg/L).RESULTS: The percentages of patients with at least 1 highly lipidic plaque (maximum lipid core burden index for any 4-mm pullback length ≥324.7) increased from 39.4% to 57.2% to 59.3% in the low, intermediate, and high hsCRP groups, respectively (P = 0.01). The proportion of patients with at least 1 highly lipidic plaque with ≥70% burden increased with hsCRP levels from 22.7% to 27.2% to 36.7%, respectively (P = 0.01). Multivariable analyses showed that increasing hsCRP was associated with higher total coronary artery lipid core burden index and plaque volume. Higher hsCRP increased the odds of having any highly lipidic plaque and those with ≥70% plaque burden.CONCLUSIONS: Among patients with recent NSTEMI, a high baseline hsCRP level was associated with the presence of pan-coronary atherosclerosis and focal high-risk plaques. (PROSPECT II & PROSPECT ABSORB - an Integrated Natural History Study and Randomized Trial; NCT02171065).}, issn = {1936-8798} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_sjbergviktor_2025, title = {Release of Uranium from a Former Iron Mine, 30 Years after Flooding}, author = {Sjöberg, Viktor and Allard, Bert}, year = {2025}, pages = {886--890}, url = {2043151}, language = {eng}, publisher = {International Mine Water Association}, keywords = {uranium; mine water; environmental impact; biogeochemical processes; environmental risks}, abstract = {The Stripa mine, located in Bergslagen, Sweden operated from the Middle Ages until 1977 and later served as a research facility for SKB until 1991, after which it was flooded. Recent studies show a notable increase in uranium concentrations in the mine water, reaching nearly 1 mg/L at 200 m depth, compared to historical levels of 10 mu g/L. This increase is linked to uranium(IV) oxidation by elevated dissolved oxygen. Further research should investigate key biogeochemical processes controlling uranium transport and long-term environmental persistence. The findings highlight regional environmental risks, including potential contamination of wells, emphasizing the mine's long-term environmental impact.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kihlbergpernilla_2025, title = {Reliability of disc diffusion testing and molecular epidemiology of penicillin-susceptible Staphylococcus aureus bacteraemia}, author = {Kihlberg, Pernilla and Bech Johannesen, Thor and Stegger, Marc and Cajander, Sara and Söderquist, Bo}, year = {2025}, journal = {Journal of Antimicrobial Chemotherapy}, volume = {80}, number = {8}, pages = {2187--2193}, doi = {10.1093/jac/dkaf187}, url = {1967103}, language = {eng}, publisher = {Oxford University Press}, abstract = {BACKGROUND: Recent studies have reported an increasing prevalence of penicillin-susceptible Staphylococcus aureus (PSSA) worldwide. The reliability of disc diffusion testing for detecting penicillin-resistance has been questioned, and the molecular epidemiology of PSSA has not been studied to the same extent as that of MRSA strains.OBJECTIVES: To investigate the reliability of the disc diffusion method for detecting penicillin-resistance in S. aureus, and to examine the prevalence and molecular epidemiology of PSSA in bloodstream infections.METHODS: A total of 258 bacteraemic isolates obtained from one geographic region in Sweden during 2018-2019 were analysed using the disc diffusion test to detect penicillin-resistance, and genome sequenced to examine the prevalence of the blaZ gene and the molecular epidemiology of PSSA.RESULTS: Phenotypic susceptibility to penicillin correlated strongly with the absence of the blaZ gene, with nearly 98% concordance. The prevalence of PSSA among patients with bacteraemia was 35.1%, highlighting the need for penicillin-susceptibility testing. Additionally, population structure analyses revealed substantial genetic diversity, underscoring the complexity of the PSSA epidemiology. The PSSA belonged to diverse clonal lineages, with CC5 and CC45 dominating our cohort, similar to findings in Spain, Australia, and other parts of Sweden. However, our study revealed a higher prevalence of CC12 compared with other regions, underscoring the importance of local epidemiological surveillance.CONCLUSIONS: These findings validate the reliability of EUCAST's disc diffusion method, showing a high prevalence of PSSA, and provide insight into the genetic underpinnings of penicillin-susceptibility in S. aureus.}, issn = {0305-7453} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_norbeckdanielwidarsson_2025, title = {Reliability of nociceptive monitors vs. standard practice during general anesthesia : a prospective observational study}, author = {Norbeck, Daniel Widarsson and Lindgren, Sophie and Wolf, Axel and Jildenstål, Pether}, year = {2025}, journal = {BMC Anesthesiology}, volume = {25}, number = {1}, doi = {10.1186/s12871-025-02923-4}, url = {1935203}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {analgesia; and intraoperative analgesia; anesthesia monitoring; minimally invasive abdominal interventions; nociception level index (nol); nociception monitoring; painsensor; post-operative pain; skin conductance algesimeter (sca); surgical pain management}, abstract = {BACKGROUND: Inadequate or excessive nociceptive control during general anesthesia can result in significant adverse outcomes. Using traditional clinical variables, such as heart rate, systolic blood pressure, and respiratory rate, to assess and manage nociceptive responses is often insufficient and could lead to overtreatment with both anesthetics and opioids. This study evaluated the feasibility and effectiveness of three nociception monitoring techniques Nociception Level Index (NOL), Skin Conductance Algesimeter (SCA) and heart rate monitoring in patients undergoing image-guided, minimally invasive abdominal interventions under general anesthesia.METHOD: This prospective observational study collected data from 2022 to 2024. All patients were anesthetized according to the department's routine, and predetermined events were recorded. Two commercially available nociception monitors, the PMD-200 from Medasense (NOL) and PainSensor from MedStorm (SCA), were used, and their data were collected along with various hemodynamic parameters. The three nociception monitoring techniques were compared during predetermined events.RESULT: A total of 49 patients were included in this study. NOL and SCA demonstrated higher responsiveness than HR for all events except for skin incision. The comparison of the values above and below the threshold for each nociceptive stimulus showed significance for all measurements using the SCA and NOL. However, using HR as a surrogate for nociception with a threshold of a 10% increase from baseline, the difference was significant only at skin incision. There was no variation in the peak values attributable to differences in patients' age. Weight was a significant predictor of the peak NOL values.CONCLUSION: NOL and SCA demonstrated superior sensitivity and responsiveness to nociceptive stimuli compared to HR, effectively detecting significant changes in nociceptive thresholds across various stimuli, although responses during skin incision showed no such advantage.TRIAL REGISTRATION: Clinical trial - NCT05218551.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mendesbeatriz_2025, title = {RELIABILITY OF SLE-DAS, SLEDAI-2K, AND PGA INSTRUMENTS IN ASSESSING SLE DISEASE ACTIVITY : A STUDY AMONG GLOBAL LUPUS EXPERTS}, author = {Mendes, Beatriz and Mazeda, Carolina and Jesus, Diogo and Henriques, Carla and Matos, Ana and Gonzalez, Irene Altabas and Andrade, Samuel and Appenzeller, Simone and Bertsias, George and Cervera, Ricard and Costedoat-Chalumeau, Nathalie and Fanouriakis, Antonis and Fragoso, Thiago and Gatto, Mariele and Kovacs, Laszlo and Mok, Chi Chiu and Parodis, Ioannis and Pego-Reigosa, Jose Maria and Piga, Matteo and Rahman, Anisur and Sjöwall, Christopher and Tektonidou, Maria and Touma, Zahi and Ugarte-Gil, Manuel Francisco and Zen, Margherita and Doria, Andrea and Ines, Luis}, year = {2025}, journal = {Journal of Rheumatology}, volume = {52}, number = {Suppl. 1}, pages = {16--17}, doi = {10.3899/jrheum.2025-0390.O016}, url = {2013956}, language = {eng}, publisher = {The Journal of Rheumatology}, abstract = {Background/Purpose: Reliability measures the consistency of an instrument’s assessments. Instruments intended for clinical and research use must exhibit high reliability. There is a need for studies that evaluate and compare the reliability of different instruments used to measure SLE disease activity. This study aims to estimate the intrarater and interrater reliability of 3 SLE disease activity measurement tools as assessed by lupus experts: the SLE Disease Activity Score (SLE-DAS), the SLE Disease Activity Index 2000 (SLEDAI-2K), and the Physician Global Assessment (PGA).[1,2]Methods: A group of 19 lupus experts from 12 countries (Europe, North America, South America, and Asia) evaluated 24 clinical case vignettes of SLE covering a wide spectrum of organ manifestations and disease severity. All raters completed a training on scoring rules for SLE-DAS, SLEDAI-2K and PGA before assessing the clinical vignettes. Raters scored each clinical vignette with SLE-DAS, SLEDAI-2K, and PGA twice, with at least a 10-day interval between rounds. The clinical vignettes were randomly ordered and assessed through an online survey. Intrarater and interrater reliability were assessed using the Intraclass Correlation Coefficient (ICC) and reported with 95% CI. For this analysis, ICC estimates were derived from a two-way random effects model (single rater). All calculations were performed using the Stata Statistical Software (Release 17) with the kappaetc module. The Coefficient of Variation (CV) was also used as a measure of reliability.[3] The CV was calculated for each vignette, based on the 19 measurements from each rater, for SLE-DAS, SLEDAI-2K, and PGA. Then, for each disease activity measure, the mean of the CV values across the 24 vignettes was used as a summary measure of within-subject variability and is expressed as a percentage.Results: The 24 clinical vignettes represented a wide variety of active SLE manifestations, including skin rash (20.8%), arthritis (12.5%), renal involvement (12.5%), thrombocytopenia (12.5%), cardiac/pulmonary involvement (12.5%), mucocutaneous vasculitis (8.3%), serositis (8.3%), and neuropsychiatric SLE (8.3%). Systemic vasculitis, myositis, alopecia, hemolytic anemia, and leukopenia were each present in 4.2% of the vignettes. Hypocomplementemia and/or positive anti-dsDNA were present in 75.0%. All the 19 lupus experts completed 2 rounds of assessment of the 24 clinical vignettes, totaling 912 case assessments. Scores ranged from 0.37 to 27.37 in SLE-DAS, 0 to 21 in SLEDAI-2K, and 0.0 to 3.0 in PGA. The interrater ICCs were 0.93, 0.91, and 0.74, and the intrarater ICCs were 0.94, 0.93, and 0.88 for SLE-DAS, SLEDAI-2K, and PGA, respectively. The CVs (first rating round) were 8.2%, 19.7%, and 41.1% for SLE-DAS, SLEDAI-2K, and PGA, respectively. The ICCs (95% CI) and CVs for SLE-DAS, SLEDAI-2K, and PGA are detailed in Table 1 and Table 2.Conclusions: This study demonstrates that both SLE-DAS and SLEDAI-2K presented good to excellent interrater reliability, indicating strong consistency in scoring across different experts. Notably, SLE-DAS achieved excellent intrarater reliability, reflecting a high degree of stability in individual assessments between assessments at different times. Both SLEDAI-2K and PGA exhibited good to excellent intrarater reliability, while PGA showed moderate to good interrater reliability. Furthermore, SLE-DAS exhibited the lowest within-subject variability, as evidenced by its lower CV values compared to SLEDAI-2K and PGA.References: [1.] Jesus D. Ann Rheum Dis 2019;78:365-71. [2.] Piga M. Lancet Rheumatol 2022;4:e441-9. [3.] Shechtman O. In: S.A.R. Doi, G.M. Williams (Eds.). Methods Clin Epidemiol 2013:39-49.}, issn = {0315-162X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_holmermagnus_2025, title = {Reply : Competing risk and surveillance thresholds for HCC in Patients with PSC}, author = {Holmer, Magnus and Ingre, Michael and Färkkilä, Martti and Ponsioen, Cyriel and Mol, Bregje and Schramm, Christoph and Folseraas, Trine and Wiencke, Kristine and Cazzagon, Nora and Catanzaro, Elisa and Molinaro, Antonio and Nilsson, Emma and Vessby, Johan and Kechagias, Stergios and Nyhlin, Nils and Werner, Mårten and Bergquist, Annika}, year = {2025}, journal = {Hepatology}, doi = {10.1097/HEP.0000000000001651}, url = {2023807}, language = {eng}, publisher = {Wiley-Interscience Publishers}, issn = {0270-9139} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rosenbladandreaskarlsson_2025, title = {Reply to the letter to the editor about "recurrences after nephron-sparing treatments of renal cell carcinoma : a competing risk analysis" by Lundgren and Radros}, author = {Rosenblad, Andreas Karlsson and Hashim, Bassam Mazin and Lindblad, Per and Ljungberg, Börje}, year = {2025}, journal = {World journal of urology}, volume = {43}, number = {1}, doi = {10.1007/s00345-025-05526-3}, url = {1943831}, language = {eng}, publisher = {Springer}, issn = {0724-4983} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_grnnolle_2025_2, title = {Reply to Yang et al, Tian and Huang, and Wang et al}, author = {Grännö, Olle and Bergemalm, Daniel and Salomon, Benita and Halfvarson, Jonas}, year = {2025}, journal = {Gastroenterology}, volume = {169}, number = {5}, pages = {1083--1084}, doi = {10.1053/j.gastro.2025.06.015}, url = {1977438}, language = {eng}, publisher = {American Gastroenterology Association Institute}, issn = {0016-5085} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lashkariniassamaneh_2025, title = {Representation of women in cardiovascular disease management : a systematic analysis of ESC guidelines}, author = {Lashkarinia, S. Samaneh and Lee, Angela W. C. and Baptiste, Tiffany M. G. and Barrows, Rosie K. and Sillett, Charles P. and Rodero, Cristobal and Tayal, Upasana and de Marvao, Antonio and Panay, Nicholas and Williamson, Catherine and Blomström-Lundqvist, Carina and Haugaa, Kristina and Casadei, Barbara and Maleckar, Mary M. and Strocchi, Marina and Niederer, Steven A.}, year = {2025}, journal = {Open heart}, volume = {12}, number = {2}, doi = {10.1136/openhrt-2025-003320}, url = {1994063}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {delivery of health care; outcome assessment; health care; quality of health care; women}, abstract = {OBJECTIVE: Sex differences play a critical role in the presentation, progression and treatment outcomes of cardiac diseases. However, historical male predominance in clinical studies has led to disparities in evidence supporting care for both sexes. Clinical guidelines are essential for cardiovascular care, shaping practice and influencing patient outcomes. In this study, we reviewed 34 European Society of Cardiology (ESC) guidelines between 2002 and 2024 to evaluate the representation of women and the inclusion of female-specific recommendations.METHODS: We compiled 136 gender-related keywords, validated by six clinicians, and quantified their occurrence across guidelines. While our primary analysis focused on female-specific keywords, we also identified male-specific terms as a comparison point to help quantitatively interpret the representation of female-specific terminology in the guidelines. Each guideline underwent independent review by two auditors who used structured questions to assess its sensitivity to female-specific differences in disease presentation, diagnosis, management and treatment.RESULTS: The most frequent terms were 'pregnancy', 'women' and 'sex', with 1768 (17.9%), 1573 (15.9%) and 676 (6.8%) overall repetitions, respectively, contrasted against 'cardiac' (6932 occurrences) as a baseline. Results showed inconsistency in addressing female-specific factors and health considerations in ESC guidelines. We were able to assess the relative frequency of female-specific language and highlight in contrast areas where female representation in cardiovascular guidelines may be insufficient. Most guidelines (24/34) mentioned pregnancy and provided related recommendations, with one of the guidelines entirely dedicated to cardiovascular disease (CVD) in pregnancy (2018) and a new one planned for 2025. Only 10/30 guidelines acknowledged menopause as a CVD risk factor and offered recommendations for clinical practice.CONCLUSIONS: These findings highlight the need for systematic integration of female-specific considerations across all guidelines. In the wider context, there is also a need for improved representation of women in clinical trials and for making the available evidence on which the guidelines are based less biased toward men.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_denkthomas_2025_3, title = {Republik på svenska}, author = {Denk, Thomas and Åberg, Jenny}, year = {2025}, pages = {23--33}, url = {1979229}, language = {swe}, publisher = {SOM-institutet}, keywords = {republik; president; presidentmakt; monarki; parlamentarism}, abstract = {Sedan demokratins införande har frågan om monarkins avskaffande och övergång till republik aktualiserats regelbundet. Frågan är dock vilken form av republik som önskas mer preciserat. Vilken typ av presidentmakt önskas vid ett införande av republik? Detta kapitel undersöker vilka befogenheter som medborgarna önskar ge en president vid ett införande av republik. Analyserna visar att en stor andel saknar uppfattningar i frågan. Bland de svarande med uppfattningar finns det tre grupper. En grupp som endast vill ge presidenten representativa uppgifter, en annan grupp som också vill ge presidenten möjlighet att lämna förslag till riksdagen, och avslutningsvis en grupp som önskar ge presidenten mer omfattande befogenheter. Analyserna visar också att inställningen till presidentbefogenheter har samband, om än svaga, med inställning till införandet av republik, utbildningsnivå, politiskt intresse, demokratinöjdhet, vänster-höger-position och partisympatier. Sammantaget är det inget i analyserna som tyder på att det parlamentariska statsskicket skulle utmanas vid ett inrättande av republik.}, file = {https://oru.diva-portal.org/smash/get/diva2:1979229/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_radkekatarzyna_2025, title = {Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma}, author = {Radke, Katarzyna and Aaltonen, Kristina and Muciño-Olmos, Erick A. and Esfandyari, Javanshir and Adamska, Aleksandra and Siaw, Joachim T. and Adamic, Dora and Lago, Chiara and Mañas, Adriana and Seger, Alexandra and Hansson, Karin and Rogova, Oksana and Lehn, Sophie and Mason, Daniel J. and O'Donovan, Daniel J. and Roberts, Ian and Lock, Antonia and Brennan, Jane and Pietras, Kristian and Davies, Emma J. and Spégel, Peter and Bedoya Reina, Oscar C. and Brown, David and Thompson, Neil T. and Spadoni, Cesare and Bexell, Daniel}, year = {2025}, journal = {EMBO Molecular Medicine}, doi = {10.1038/s44321-025-00349-6}, url = {2024496}, language = {eng}, publisher = {EMBO Press}, keywords = {drug repurposing; machine learning; neuroblastoma; phenothiazine; statin}, abstract = {Relapse and treatment resistance are common in children with high-risk neuroblastoma, and novel therapies are needed. Conventional drug discovery is slow, expensive, often fails in practice, and consequently falls short in addressing pediatric and rare conditions. In such instances, drug repurposing is a promising strategy. Here, we used two independent in silico prediction tools including machine learning to identify approved drugs for repurposing against neuroblastoma. The combination of statins and phenothiazines showed strong synergistic effects in human neuroblastoma organoids, decreased tumor growth, and prolonged survival in MYCN-amplified neuroblastoma patient-derived xenografts. The drug combination altered cholesterol metabolism through two different mechanisms and induced a phenotypic change toward an adrenergic state in vitro, which was associated with enhanced chemosensitivity. Integration of the drug combination into standard-of-care chemotherapy regressed tumors and prolonged survival in chemoresistant patient-derived xenografts. Thus, a combination of safe and approved medications added to standard-of-care chemotherapy outperforms chemotherapy alone in chemoresistant neuroblastoma.}, issn = {1757-4676} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mobergnadia_2025_1, title = {Research on Power in Musical Practices and Institutions}, author = {Moberg, Nadia and de Boise, Sam and Georgii-Hemming, Eva and Han, Joshua}, year = {2025}, journal = {European Journal of Cultural Studies}, doi = {10.1177/13675494251387476}, url = {1996862}, language = {eng}, publisher = {Sage Publications}, keywords = {inequality; inequity; musical institutions; musical practices; music research; power relations}, abstract = {Despite extensive research on inequalities in music, it remains unclear how power is conceptualized and analyzed within musical practices and institutions. The purpose of this study is to explore contemporary academic research on power in musical practices and institutions. Through a scoping literature review of peer-reviewed articles published between 2013 and 2023, the study examines how inequalities in music are framed and explored. Our findings reveal a strong emphasis on gender, race, and social justice, with music education emerging as the most studied context. Despite frequent references to power, the concept is often left undefined, and research primarily highlights marginalized groups’ experiences rather than the mechanisms through which power operates, limiting its ability to address structural inequities. We suggest that future research further engage with how power operates, is maintained, and contested in musical institutions and practices, with particular attention to dominant groups, material power, and institutional mechanisms shaping inequalities.}, issn = {1367-5494} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_matrnemarie_2025_3, title = {Resilience, quality of life and outcomes after stroke in Sweden : A municipality-based outcomes study}, author = {Matérne, Marie and Appelros, Peter and Jarl, Gustav and Simpson, Grahame and Arvidsson Lindvall, Mialinn}, year = {2025}, url = {2009102}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_matrnemarie_2025_4, title = {Resilience, Quality of Life and Outcomes After Stroke In Sweden : A Municipality-Based Outcomes Study}, author = {Matérne, Marie and Jarl, Gustav and Simpson, Grahame and Appelros, Peter and Lindvall, Mialinn Arvidsson}, year = {2025}, journal = {Brain Injury}, volume = {39}, number = {Suppl. 1}, pages = {S71--S72}, url = {2036889}, language = {eng}, publisher = {Taylor & Francis}, issn = {0269-9052} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_urberglinnea_2025_3, title = {Resisting sustainable development : an analysis of young people’s online discussions}, author = {Urberg, Linnea and Öhman, Johan}, year = {2025}, journal = {Journal of Youth Studies}, volume = {28}, number = {7}, pages = {1021--1037}, doi = {10.1080/13676261.2024.2322607}, url = {1841025}, language = {eng}, publisher = {Taylor & Francis}, keywords = {resistance; tensions; environmental capital; online communication; disadvantaged}, abstract = {Society is currently facing and experiencing a fundamental environmental and social climate-related crisis. Despite this, many groups in society are either opposed to or sceptical about various sustainability reforms, research on the climate crisis and other environmental issues. This article aims to clarify the underlying logic of how and why some young people express resistance, and how habits, values and identity contribute to negative emotions and doubts about sustainable development, climate change and the current environmental crisis. The analysed data originates from an internet forum where young people can discuss political matters. First, through a qualitative inductive content analysis, four tensions were identified that either led to or were manifested as resistance. Second, a deductive content analysis was conducted based on Bourdieu’s forms of capital. The results show that resistance was often manifested as a defence of economic advantage and a fear of losing or experiencing a low cultural or social capital in the process of sustainability. Due to these fears other groups, such as women, immigrants and urban populations, were blamed by those who saw themselves as disadvantaged in a sustainable transformation.}, issn = {1367-6261} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_saersjohannes_2025_1, title = {Respiratory symptoms, lung function, and fraction of exhaled nitric oxide before and after assignment in a desert environment-a cohort study (vol 189, 106643, 2021)}, author = {Saers, Johannes and Andersson, Lena and Janson, Christer and Sundh, Josefin}, year = {2025}, journal = {Respiratory Medicine}, volume = {250}, doi = {10.1016/j.rmed.2025.108469}, url = {2029148}, language = {eng}, publisher = {Elsevier}, issn = {0954-6111} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_ebersmartin_2025_3, title = {Responsabilidad por productos sanitarios de IA en Europa. Consideraciones preliminares sobre el impacto de la nueva Directiva 2024/2853}, author = {Ebers, Martin}, year = {2025}, pages = {606--624}, url = {2024810}, language = {spa}, publisher = {Aranzadi La Ley}, abstract = {El uso de la inteligencia artificial (IA) en medicina está revolucionando el sector sanitario, pero al mismo tiempo plantea nuevos problemas de responsabilidad. Esto afecta principalmente a la responsabilidad del fabricante, armonizada en Europa por la Directiva de Responsabilidad por Productos de 1985 en los Estados miembros[1] y regulada en el futuro por la nueva Directiva adoptada en 2024 [1] Directiva del Consejo de 25 de julio de 1985 relativa a la aproximación de las disposiciones legales, reglamentarias y administrativas de los Estados miembros en materia de responsabilidad por los daños causados por productos defectuosos, DO L 210 de 7.8.1985, p. 29).A continuación, procederé en tres pasos: En primer lugar, describiré el marco jurídico general de los productos sanitarios de IA. En segundo lugar, entraré en más detalle sobre cuándo los sistemas de IA entran bajo el ámbito de aplicación dentro de la nueva Directiva como productos. Y en tercer lugar, abordaré a continuación la cuestión de qué criterios podrían aplicarse a la defectuosidad de los productos sanitarios basados en IA.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_frbertole_2025_1, title = {Response Letter}, author = {Fröbert, Ole and Pedersen, Ida B. and Hjelholt, Astrid J. and Erikstrup, Christian and Cajander, Sara}, year = {2025}, journal = {Atherosclerosis}, volume = {409}, doi = {10.1016/j.atherosclerosis.2025.120499}, url = {2007060}, language = {eng}, publisher = {Elsevier}, issn = {0021-9150} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karlqvistsara_2025, title = {Response to Dai et al}, author = {Karlqvist, Sara and Sachs, Michael C. and Eriksson, Carl and Cao, Yang and Montgomery, Scott and Ludvigsson, Jonas F. and Olén, Ola and Halfvarson, Jonas}, year = {2025}, journal = {American Journal of Gastroenterology}, volume = {120}, number = {1}, pages = {260--261}, doi = {10.14309/ajg.0000000000003199}, url = {1925930}, language = {eng}, publisher = {Blackwell Publishing}, issn = {0002-9270} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wistrandcamilla_2025_1, title = {Response to "Letter to editor: Bacterial air contamination and the protective effect of coverage for sterile surgical goods: a randomized controlled trial"}, author = {Wistrand, Camilla and Söderquist, Bo and Friberg, Örjan and Sundqvist, Ann-Sofie}, year = {2025}, journal = {American Journal of Infection Control}, volume = {53}, number = {7}, pages = {805--805}, doi = {10.1016/j.ajic.2025.05.002}, url = {1985541}, language = {eng}, publisher = {Elsevier}, issn = {0196-6553} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_arnisontor_2025_1, title = {Response to ‘The Evidence Base for Electroconvulsive Therapy (ECT) in Geriatric Depression’}, author = {Arnison, Tor and Nordenskjöld, Axel}, year = {2025}, journal = {The American journal of geriatric psychiatry}, volume = {34}, number = {1}, pages = {136--137}, doi = {10.1016/j.jagp.2025.07.015}, url = {1990463}, language = {eng}, publisher = {Elsevier}, issn = {1064-7481} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zerdesioannis_2025_1, title = {Response to Yuan and Yu}, author = {Zerdes, Ioannis and Valachis, Antonis}, year = {2025}, journal = {Journal of the National Cancer Institute}, volume = {117}, number = {6}, pages = {1285--1286}, doi = {10.1093/jnci/djaf080}, url = {1948188}, language = {eng}, publisher = {Oxford University Press}, issn = {0027-8874} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_englundhans_2025, title = {Results controls and employee motivation : a systematic review of the accounting literature using self-determination theory}, author = {Englund, Hans and Gerdin, Jonas}, year = {2025}, journal = {Journal of Accounting Literature}, volume = {47}, number = {5}, pages = {588--621}, doi = {10.1108/jal-10-2024-0279}, url = {2010526}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {autonomous motivation; basic psychological needs; controlled motivation; results controls; self-determination theory; systematic literature review}, abstract = {Purpose: The purpose of this paper is twofold. First, it provides a systematic review of the expanding accounting literature which uses self-determination theory (SDT) to better understand how and why results controls (i.e. the measurement, target-setting, follow-up, and rewarding of employee work performance) can foster different types of employee motivation and the outcome effects thereof. Second, based on the identified achievements and weaknesses of this literature, it proposes an agenda for future scholarly effort.Design/methodology/approach: The present study conducts a systematic, qualitative, and in-depth review of 38 articles published from 2010 to 2024 in high-quality accounting journals, all of which use SDT in their theorizing. The literature was analyzed by means of a thematic approach using the NVivo software.Findings: A key achievement of the reviewed literature is the recognition that employees’ work motivation can be depicted as a self-determination continuum, ranging from controlled types (external and introjected motivation) to autonomous ones (identified, integrated, and intrinsic motivation). The literature has also shown that when results controls support employees’ basic psychological needs for autonomy, competence, and relatedness, this will foster more autonomous types of motivation, and vice versa when they thwart these needs. Moreover, through fostering autonomous types of motivation, these controls may not only contribute to high employee creativity and work performance but also enhance feelings of well-being and job satisfaction. This said, however, the reviewed literature also suffers from several weaknesses. These include a limited attention to key SDT ideas such as the motivational effects of individual-level personality traits and the internalization processes through which employees “take in” results controls. The literature also suffers from limited knowledge cumulativity largely as the result of diverging views on how to understand key SDT concepts and their relationships.Originality/value: To the best of our knowledge, this study is the first systematic review of the accounting literature that uses SDT as a theoretical lens to examine the influence of results controls on employee motivation. As such, it uncovers overall achievements and weaknesses which are difficult to grasp when reading individual studies. It also highlights several knowledge gaps, thereby providing a basis for future research on the motivational effects of results controls.}, issn = {0737-4607} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_thunbergulrica_2025_2, title = {Results of 1470 nanometre diode laser assisted stapedotomy}, author = {Thunberg, Ulrica}, year = {2025}, journal = {Journal of Laryngology and Otology}, volume = {139}, number = {11}, pages = {1050--1054}, doi = {10.1017/S002221512510279X}, url = {1990095}, language = {eng}, publisher = {Cambridge University Press}, keywords = {stapedotomy; diode laser; laser; otosclerosis}, abstract = {Objective; Few studies have investigated stapedotomy using 1470 nm diode laser, and thepresent article contributes with clinical experience.Methods; A retrospective analysis was conducted to investigate hearing performance of 22patients undergoing 1470 nm diode laser assisted primary stapedotomy.Results; In 8/22 cases, accidental beaches to the inner ear by the laser and in 14/22 cases thestapedotomy was performed as planned only by drill. Air-bone gap and loss of sensorineuralhearing were low and with no significant differences for groups at follow-up. No patientswith breaches by laser reported new or worse tinnitus.Conclusion; Accidental breaches in the stapes footplate using this diode laser did not appearto equate with inner ear damage within this limited cohort. Hearing outcomes was notsignificantly affected. These findings should be interpreted with caution. Further studiesevaluating this laser wavelength in stapedotomy is required}, issn = {0022-2151} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_khandokhando_2025_1, title = {Retail Merchants’ Interactions in the Cashless Payment Ecosystem : Through the Lens of Coopetition}, author = {Khando, Khando and Gao, Shang and Petersson, Johan}, year = {2025}, volume = {550 LNBIP}, pages = {300--312}, doi = {10.1007/978-3-031-94187-0_25}, url = {2028815}, language = {eng}, publisher = {Springer}, keywords = {cashless payment ecosystem; collaboration; competition; coopetition; reflexive thematic analysis; retail merchants}, abstract = {Retail merchants play a central role in driving the shift towards cashless payments. They operate within an interconnected cashless payment ecosystem, interacting directly with other actors through collaboration and competition. This study examines retail merchants’ interactions with other participants in the ecosystem, focusing on the concept of coopetition—a combination of cooperation and competition. We conducted a qualitative reflexive thematic analysis of 15 semi-structured interviews with retail merchants in Sweden. The analysis yielded five themes: Harmonizing for optimal integration, strategizing cost efficiency, balancing reliability and risk management, aligning with consumer preferences and market dynamics, and managing the evolution of payment technologies. The study contributes to the existing literature by offering a rich contextual description of retail merchants’ interaction within the cashless payment ecosystem. It highlights the importance of coopetitive interactions for retail merchants to enhance their payment operations, stay competitive, and respond to market and technological changes. These insights can guide retail merchants and other actors in optimizing their strategies for successfully implementing cashless payment systems. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_simonssonangelica_2025, title = {Rethinking Institutional Responses to Gender-Based Violence in Academia as Forms of Care in the Nordic Context : [Repensando as respostas institucionais à violência de género na Academia Nórdica como formas de cuidado]: [Repensar las respuestas institucionales a la violencia de género en la Academia Nórdica como formas de cuidado]}, author = {Simonsson, Angelica and Ovesen, Nicole and Salome Steinþórsdóttir, Finnborg and Husu, Liisa}, year = {2025}, journal = {Debate Feminista}, volume = {69}, pages = {219--246}, doi = {10.22201/cieg.2594066xe.2025.69.2495}, url = {1991245}, language = {eng}, publisher = {Universidad Nacional Autónoma de México}, keywords = {sexual harassment; gender equality policy; policy implementation; higher education; university; assédio sexual; políticas de igualdade de género; política de implementação; educação superior; universidade; acoso sexual; políticas de igualdad de género; implementación de políticas; educación superior; universidad}, abstract = {This article examines institutional responses to gender-based violence (GBV) in higher education institutions (HEI) in three Nordic countries through the lens of care, to engage in critical discussion of how such caring practices are performed, in which conditions, and who actually “cares” about GBV in HEIs. The article is drawing on three in-depth case studies of implementation of GBV policies and practices in HEIs in Finland, Iceland and Sweden, conducted in 2022. Despite the reputation of the Nordic countries as global gender equality champions, implementation of policies and practices to prevent GBV in Nordic HEI still face several challenges. Institutional responses to GBV can be a way to demonstrate institutional care, yet the actual work of caring in practice is not always granted the same recognition or value. The care work is often either person or position-dependent which impacts and may hamper long-term capacity building and institutional knowledge exchange.;Este artículo examina las respuestas a la violencia de género (VG) en instituciones de educación superior (IES) de tres países nórdicos desde la perspectiva del cuidado para entablar un debate crítico sobre cómo se llevan a cabo estas prácticas, en qué condiciones y a quién “le importa” realmente la VG en las IES. El artículo se basa en tres estudios de caso, realizados en 2022, en Finlandia, Islandia y Suecia. A pesar de la reputación de los países nórdicos como defensores mundiales de la igualdad de género, la implementación de políticas y prácticas para prevenir la VG en las IES aún tiene retos por superar. Las respuestas institucionales pueden ser una forma de demostrar el cuidado, pero la labor real en la práctica no siempre se reconoce o valora como se debería, sino que suele depender de la persona o del cargo, lo que puede obstaculizar el desarrollo de capacidades a largo plazo y el intercambio de conocimientos institucionales.;Este artigo examina as respostas institucionais à violência baseada no gênero (VBG) em instituições de ensino superior (IES) em três países nórdicos através da lente do cuidado, para se envolver numa discussão crítica sobre como essas práticas de cuidado são realizadas, em que condições e quem realmente “se preocupa” com a VBG nas IES. O artigo baseia-se em três estudos de caso na Finlândia, a Islândia e a Suécia, realizados em 2022. Apesar da reputação dos países nórdicos como campeões globais da igualdade de gênero, a implementação das políticas e as práticas para prevenir a VBG em IES nórdicas ainda enfrenta vários desafios. As respostas institucionais à VBG podem ser uma forma de demostrar o cuidado institucional, mas o trabalho real de cuidar na prática nem sempre recebe o mesmo reconhecimento ou valor. O trabalho de prestação de cuidados depende muitas vezes da pessoa ou da posição, o que afeta e pode dificultar o desenvolvimento de capacidades a longo prazo e a troca institucional de conhecimentos.}, issn = {0188-9478} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_reiserdaniel_2025_2, title = {Rethinking SLIL classifications in the age of needle arthroscopy : do we need sub-grades?}, author = {Reiser, Daniel and Kakar, Sanjeev}, year = {2025}, journal = {Bone & Joint Open}, volume = {6}, number = {11}, pages = {1466--1467}, doi = {10.1302/2633-1462.611.BJO-2025-0265.R1}, url = {2013764}, language = {eng}, publisher = {The British Editorial Society of Bone & Joint Surgery} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_13, title = {Rethinking Subjectivity in Family Abolitionist Thought}, author = {Johansson Wilén, Evelina}, year = {2025}, url = {2012464}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_elhajjvictorgabriel_2025_5, title = {Return to Work After Surgery for Degenerative Cervical Myelopathy : Prospective Data From a Swedish Nationwide Cohort of 789 Patients}, author = {El-Hajj, Victor Gabriel and Gustafsson, Marcus Roland Victor and Fariña Nuñez, Mateo Tomas and Staartjes, Victor E. and Edström, Erik and Elmi-Terander, Adrian}, year = {2025}, journal = {Neurosurgery}, doi = {10.1227/neu.0000000000003822}, url = {2007409}, language = {eng}, publisher = {Wolters Kluwer}, keywords = {cervical; degenerative cervical myelopathy; neurosurgery; return to work; spine surgery}, abstract = {BACKGROUND AND OBJECTIVES: Degenerative cervical myelopathy (DCM) is a progressive disorder that leads to significant neurological deficits, often requiring surgical decompression to prevent further decline. There are only a handful of studies analyzing return-to-work (RTW) outcomes after cervical spine surgery for DCM. This study seeks to elucidate RTW outcomes and to identify predictors preventing RTW in patients surgically treated for DCM in a nationwide prospective registry.METHODS: A nationwide cohort analysis was conducted using prospectively gathered data from patients surgically treated for DCM, from the Swedish Spine Registry. Patients with documented postoperative outcomes focusing on RTW rates from 1 to 5 years were included. To identify predictive factors affecting RTW at 1 year postoperatively, separate univariable and multivariable logistic regression models were developed, incorporating demographic, functional and clinical, as well as preoperative and postoperative data and occupational characteristics.RESULTS: A total of 789 patients were included with an average age of 52 years, with most patients working in moderate intensity jobs and nearly half were on sick leave before surgery. Most surgeries were elective, using an anterior approach. The RTW rate at 1 year was 76%, separating into 54% who had resumed full-time employment and 23% who had returned to a part-time capacity. In this cohort, 24% had not returned to work at the 1-year mark. Older age, physically demanding work, higher preoperative Neck Disability Index Score, reduced walking distance, and sickness benefits were significant predictors of a lack of RTW. CONCLUSION: 75% of the patients surgically treated for DCM returned to work within 1 year. Higher age, physically demanding work, higher Neck Disability Index Score, and full-time sickness benefits were all associated with a decreased likelihood of RTW. Recognizing these risk factors can help identify patients who may benefit from additional physical therapy, behavioral interventions, counseling, or work-place adjustments to support RTW.}, issn = {0148-396X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kttstrmmagdalena_2025_1, title = {Revaccination with pneumococcal conjugate vaccine five years after primary immunization improves immunity in patients with chronic lymphocytic leukemia}, author = {Kättström, Magdalena and Uggla, Bertil and Virta, Camilla and Melin, Merit and Ekström, Nina and Magnuson, Anders and Andersson, Per-Ola and Hammarlund, Ylva and Lockmer, Sandra and Nilsson, Ingmar and Roth, Daniel and Svensson, Magnus and Tolf, Tobias and Kimby, Eva and Norén, Torbjörn and Athlin, Simon}, year = {2025}, journal = {Haematologica}, volume = {110}, number = {8}, pages = {1774--1785}, doi = {10.3324/haematol.2024.286942}, url = {1942990}, language = {eng}, publisher = {Ferrata Storti Foundation}, abstract = {Patients with chronic lymphocytic leukemia (CLL) have impaired response to vaccination, which calls for improved vaccination strategies. This study aimed to evaluate antibody persistence five years after pneumococcal vaccination and response to revaccination. Seventyfour CLL patients and 31 controls, all primary immunized with 13-valent conjugated pneumococcal vaccine (PCV13) or 23-valent polysaccharide vaccine (PPSV23), were included. Antibody persistence was assessed, followed by revaccination with PCV13 and a second revaccination with PCV13 or PPSV23. Serological protection (SP), defined as serum serotype specific IgG concentration ≥0.35 μg/mL for ≥70% of shared serotypes, did not differ significantly in CLL patients primary immunized with PCV13 or PPSV23 (RR 2.7 (95% CI 0.5-13.1)), but was lower in patients compared to controls (10% vs 32%; RR 0.3 (0.1-0.7)). Following revaccination with PCV13, serological response (SR), defined as ≥2-fold increase for ≥70% of shared serotypes, was 24% in patients primary immunized with PCV13 vs 12% with PPSV23 (RR 2.0 (0.6-6.9)). A second revaccination with PCV13 significantly improved SR while PPSV23 did not further improve immunity. Our findings suggest that repeated doses of a T-cell dependent pneumococcal vaccine improve protection in CLL patients. The study is registered at www.clinicaltrials.gov (NCT05316831).}, issn = {0390-6078} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tallrothmattias_2025, title = {Reversal treatment and clinical outcomes in acute intracranial haemorrhage associated with oral anticoagulant use : protocol of a planned systematic review and meta-analysis}, author = {Tallroth, Mattias and Östlundh, Linda and Büki, Andras and Cao, Yang and von Euler, Mia and Ström, Jakob O.}, year = {2025}, journal = {BMJ Open}, volume = {15}, number = {2}, doi = {10.1136/bmjopen-2024-090357}, url = {1938678}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {intracerebral haemorrhage; neurosurgery}, abstract = {INTRODUCTION: Reversal treatment is commonly used for managing oral anticoagulant (OAC)-associated intracranial haemorrhages. Its effects on mortality are still understudied, particularly in various subtypes of intracranial haemorrhages. This systematic review and meta-analysis aims to synthesise the available data to study the impact of reversal therapies on mortality following various OAC-associated acute intracranial haemorrhages.METHODS AND ANALYSIS: This protocol follows the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) Protocols, and the final review will be reported in accordance with the PRISMA reporting guidelines. This systematic review and meta-analysis will include studies that assess contemporary reversal treatment in comparison to no reversal treatment, in cases of OAC-associated intracranial haemorrhage. Stratification will be performed for the types of bleeding as well as OAC at bleeding onset. Preliminary searches to determine search term inclusions were conducted in May-August 2024 in the electronic databases Embase, PubMed, Scopus and Web of Science without language and publication date restrictions. Randomised controlled studies, non-randomised controlled trials, and observational studies will be considered for the final meta-analysis. Three reviewers (MT, JOS and AB) will screen titles and abstracts, and one reviewer (MT) will subsequently conduct full-text screening. Risks of bias will be assessed by MT using tools such as Risk of Bias 2, Risk Of Bias In Non-randomised Studies - of Interventions and the Newcastle-Ottawa Scale. Heterogeneity among the study results will be assessed using the I² statistic. If appropriate, a random-effects meta-analysis model will be performed. Subgroup analyses and meta-regression (if applicable) will be performed to assess sources of heterogeneity among (1) intracranial haemorrhage types, (2) OAC drugs and (3) study types, with randomised controlled trials being the primary focus.ETHICS AND DISSEMINATION: Ethical approval is not needed as this project involves previously published data. We intend to publish the results in a peer-reviewed journal.PROSPERO REGISTRATION NUMBER: CRD42024556420.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_brumwagners_2025, title = {Reversible tau hyperphosphorylation in hibernation : a blood biomarker and brain tissue study}, author = {Brum, Wagner S. and Montoliu-Gaya, Laia and Brinkmalm, Gunnar and Piotrowska, Diana and Camporesi, Elena and Jäger, Carsten and Isaksson, Helena S. and Martin, Sven and Kindberg, Jonas and Lantero-Rodriguez, Juan and Ferrari-Souza, João Pedro and Moscoso, Alexis and Benedet, Andrea L. and Janelidze, Shorena and Gobom, Johan and Zetterberg, Henrik and Hansson, Oskar and Zimmer, Eduardo R. and Ashton, Nicholas J. and Arendt, Thomas and Lashley, Tammaryn and Stieler, Jens T. and Holzer, Max and Fröbert, Ole and Blennow, Kaj}, year = {2025}, journal = {Acta Neuropathologica}, volume = {150}, number = {1}, doi = {10.1007/s00401-025-02930-2}, url = {2002510}, language = {eng}, publisher = {Springer}, keywords = {alzheimer’s disease; hibernation; neuropathology; phosphorylated tau; plasma biomarkers; tau; tauopathies}, abstract = {Tau hyperphosphorylation, a key neuropathological feature of tauopathies such as Alzheimer's disease (AD), also occurs physiologically during mammalian hibernation and is fully reversed upon arousal, offering a unique translational model to study tau metabolism. However, limited data exist on insoluble and soluble tau alterations during hibernation and on patterns of tau fragment concentrations in the hibernating mammalian brain. We quantified tau biomarkers in plasma samples from ten free-ranging brown bears (Ursus arctos), captured during both their active summer period and hibernation in the winter, using clinically validated immunoassays and immunoprecipitation mass spectrometry (IP-MS) techniques. We also analyzed brain tissue from ten golden Syrian hamsters (Mesocricetus auratus) subjected to induced torpor (hibernation) versus euthermic (non-hibernating) states by quantifying multiple phosphorylated and non-phosphorylated tau peptides with an IP-MS method previously applied in human brain tissue. In brown bears, plasma levels of phosphorylated tau (p-tau) biomarkers p-tau181 and p-tau217 significantly increased during hibernation compared to summer (median increases of 362% and 294% by IP-MS, respectively), with similar increases found with immunoassays. Additional plasma p-tau biomarkers associated with AD pathology, including p-tau205 and p-tau231, were also increased during bear hibernation. In hamster brains, p-tau217, and p-tau231 were similarly elevated during torpor, while tau fragments from the microtubule-binding region (MTBR), associated with tangle aggregation, were not increased. In contrast, brain tissue from n = 10 AD patients, analyzed with the same IP-MS method, exhibited striking increases in p-tau (~ 50,000% for p-tau217) and MTBR fragments (~ 20,000% for MTBR tau354-369) compared with n = 10 human controls. We show that hibernation-linked tau hyperphosphorylation involves some of the same phospho-sites altered in AD, but occurs without MTBR tau aggregation. This highlights hibernation as a reversible, non-pathological model to study tau biology and mechanisms underlying AD due to its reversibility and lack of tau aggregation despite hyperphosphorylation in key AD tau phospho-sites.}, issn = {0001-6322} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrkvallanders_2025_4, title = {Revisiting Cultures of Inscription : Digital Pencils in Swedish Compulsory Schools}, author = {Björkvall, Anders and Lindstrand, Fredrik and Melander, Ida}, year = {2025}, url = {1938071}, language = {eng}, publisher = {Örebro University}, abstract = {This research report presents the results from the project Connecting digital and analog literacy: The potential of the digital pencil for text creation in schools (DigiPen). Digital pencils are used for writing, drawing, and pointing on tablet or laptop screens. So far, they have not been used to any larger extent in Swedish schools. Two studies of uses of digital pencils in Swedish compulsory schools are presented. One was carried out in a fourth-grade class and one in an eighth-grade class. The report describes the potentials of digital pencils as tools in schools for writing by hand, drawing, and thinking, as well as for performing tasks other than those that are possible with analog pencils. A number of detailed recommendations are presented, based on the empirical findings of the studies. The recommendations are directed toward teachers, teacher students, school management, and educational policymakers, as well as representatives of the hardware and software industry.}, file = {https://oru.diva-portal.org/smash/get/diva2:1938071/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sundlouise_2025, title = {Revisiting the political in environmental and sustainability education – a global justice-oriented approach}, author = {Sund, Louise and Öhman, Johan}, year = {2025}, journal = {Environmental Education Research}, pages = {1--17}, doi = {10.1080/13504622.2025.2567938}, url = {2004421}, language = {eng}, publisher = {Routledge}, keywords = {environmental and sustainability education; global citizenship education; global justice; educational guidelines}, abstract = {This paper revisits and expands a decade-old call to engage the political dimensions of environmental and sustainability education (ESE). With intensifying climate impacts and widening global inequities, global justice has become central to ESE. Climate change is not only a scientific concern but a lived reality shaped by colonial legacies, structural inequalities, and power imbalances. Drawing on critical global citizenship education (GCE) and educational philosophy, we examine the roles of educators amid interwoven environ-mental, social, and political crises. Teaching sustainability is not merely technical or scientific but also ethical, existential, and political. Inspired by recent scholarship across ESE, GCE, political science, and philosophy, we outline five interrelated educational guidelines for a global justice-oriented ESE. These guidelines support educators in critically addressing intersecting injustices through meaningful, critical engagement. We conclude that ESE’s future lies in creating transformative spaces that foster ethical responsibility, political awareness, and collective action for a just and sustainable world.}, issn = {1350-4622}, file = {https://oru.diva-portal.org/smash/get/diva2:2004421/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mackeyallison_2025, title = {Revisiting the transient-evoked otoacoustic emissions passing criteria used for newborn hearing screening}, author = {Mackey, Allison and Mäki-Torkko, Elina and Uhlen, Inger}, year = {2025}, journal = {International Journal of Audiology}, volume = {64}, number = {5}, pages = {488--497}, doi = {10.1080/14992027.2024.2378808}, url = {1888854}, language = {eng}, publisher = {Taylor & Francis}, keywords = {newborn hearing screening; transient-evoked otoacoustic emissions; childhood hearing loss; early hearing detection and intervention; sensitivity; false negatives; mild hearing loss}, abstract = {Objective: To assess transient-evoked otoacoustic emissions (TEOAE) data from 15 years of a newborn hearing screening program and evaluate how well various criteria separate ears with and without hearing loss.Design: Retrospective review of TEOAE data using logistic regression, receiver operating characteristic curves, and cumulative percentage graphs.Study sample: Children with hearing loss who passed TEOAE screening as a newborn were compared to children who failed TEOAE screening and normal hearing children who either passed or failed. Exclusions were applied for acquired hearing loss or auditory neuropathy.Results: Ears with hearing loss that passed screening had significantly lower TEOAE response levels compared to ears with normal hearing. Noise levels, test times, and number of sweeps were also lower. Most of these ears had mild hearing loss. Logistic regression results showed that high-frequency TEOAE response level is the best predictor of hearing loss. A multivariate "logit" score calculated from the regression was the best indicator for separating ears with hearing loss from ears with normal hearing.Conclusions: TEOAE response levels or an algorithm which incorporates logit scores should be considered as a minimum passing criterion to increase the sensitivity of the TEOAE screening.}, issn = {1499-2027} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hazrarishi_2025_3, title = {REvolve : Reward Evolution with Large Language Models using Human Feedback}, author = {Hazra, Rishi and Sygkounas, Alkis and Persson, Andreas and Loutfi, Amy and Zuidberg dos Martires, Pedro}, year = {2025}, pages = {25710--25751}, doi = {10.48550/arXiv.2406.01309}, url = {1993704}, language = {eng}, publisher = {International Conference on Learning Representations, ICLR}, abstract = {Designing effective reward functions is crucial to training reinforcement learning (RL) algorithms. However, this design is non-trivial, even for domain experts, due to the subjective nature of certain tasks that are hard to quantify explicitly. In recent works, large language models (LLMs) have been used for reward generation from natural language task descriptions, leveraging their extensive instruction tuning and commonsense understanding of human behavior. In this work, we hypothesize that LLMs, guided by human feedback, can be used to formulate reward functions that reflect human implicit knowledge. We study this in three challenging settings - autonomous driving, humanoid locomotion, and dexterous manipulation - wherein notions of “good” behavior are tacit and hard to quantify. To this end, we introduce REvolve, a truly evolutionary framework that uses LLMs for reward design in RL. REvolve generates and refines reward functions by utilizing human feedback to guide the evolution process, effectively translating implicit human knowledge into explicit reward functions for training (deep) RL agents. Experimentally, we demonstrate that agents trained on REvolve-designed rewards outperform other state-of-the-art baselines. } } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_vinayakpatilrajesh_2025_3, title = {RFID Integrated with Human Interface System for Autonomous Shopping Tram with Integrated Bill Generator}, author = {Vinayak Patil, Rajesh}, year = {2025}, doi = {10.1201/9781003538271-25}, url = {1993495}, language = {eng}, publisher = {CRC Press}, abstract = {An important step forward in automated tram systems for retail automation has been made with the use of RFID technology to create an integrated bill generator in the system. The design of an automatic shopping tram with an integrated bill generator is presented. Radio frequency identification (RFID) technology will be used to accomplish the automatic bill generator, while ultrasonic and infrared (IR) sensors are integrated into the automated system to enable autonomous movement. LCD_I2C will be installed in the tram to improve user convenience and the shopping experience. The Arduino Uno R3 microcontroller will be used to integrate all the components. By combining RFID modules specifically, the RC522, an Arduino Uno microcontroller, LCD, and ultrasonic and infrared sensors, the system offers users a user-friendly interface and satisfied customers.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_frbertole_2025_2, title = {Risk Defines Reward in Influenza Vaccination}, author = {Fröbert, Ole}, year = {2025}, journal = {Journal of the American College of Cardiology}, volume = {86}, number = {25}, pages = {2648--2650}, doi = {10.1016/j.jacc.2025.11.010}, url = {2024426}, language = {eng}, publisher = {Elsevier}, keywords = {chronic kidney disease; high-dose; influenza; pragmatic; randomized controlled trial; registry; risk group; vaccination}, issn = {0735-1097} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hukejia_2025, title = {Risk factors, impact, and healthcare use related to initial suicide attempts : comprehensive analysis of Swedish population}, author = {Hu, Kejia and Nguyen, Thuy-Dung and Borges, Karen and Kuja-Halkola, Ralf and Butwicka, Agnieszka and Brikell, Isabell and Crowley, James J. and Chang, Zheng and D'Onofrio, Brian M. and Larsson, Henrik and Lichtenstein, Paul and Rück, Christian and Bulik, Cynthia and Sullivan, Patrick and Fang, Fang and Lu, Yi}, year = {2025}, journal = {BMJ Medicine}, volume = {4}, number = {1}, doi = {10.1136/bmjmed-2024-001129}, url = {1970001}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {public health}, abstract = {OBJECTIVE: To provide a comprehensive analysis of initial suicide attempts, covering incidence, risk factors, outcomes, and healthcare use in the month before and the month after the attempts.DESIGN: Comprehensive analysis of the Swedish population that included three designs: a retrospective cohort study to investigate incidence and healthcare use, a nested case-control study to investigate risk factors, and a matched cohort study to examine subsequent suicide attempts and mortality.SETTING: Comprehensive Swedish national registers that include patient diagnoses from hospitals and specialist outpatient care, and cause of death information updated to the end of 2019. PARTICIPANTS: 3.7 million people born in Sweden in 1963-98 and followed from age 10 to 57 years.MAIN OUTCOME MEASURE: First lifetime suicide attempt identified in patient and death registers using ICD (international classification of diseases) codes for intentional self-harm, any self-harm with lethal methods or requiring hospital admission, or any self-harm resulting in death.RESULTS: The lifetime risk of an initial suicide attempt in the study population was 4.6%, with greater risk in females and highest risk between ages 18 and 24. One in 10 families in Sweden had at least one family member who attempted suicide. Overdose and poisoning were the most common methods. Previous psychiatric disorders, general medical diseases, and adverse life events were associated with increased risk of initial suicide attempt, while higher socioeconomic status was associated with decreased risk. People with an initial suicide attempt were at substantially increased risk of subsequent attempts (hazard ratio 23.4), death by suicide (16.4), and all cause mortality (7.3). At least 60% of those who made an initial suicide attempt had a healthcare contact in the month before the attempt.CONCLUSIONS: This study provides comprehensive data on the incidence, risk factors, outcomes, and healthcare use of initial suicide attempts in the Swedish population, highlighting the need for systematic prevention efforts for people who have attempted suicide for the first time.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bjerregaardfelix_2025, title = {Risk Factors in Elective Colon Surgery for the Elderly : A Retrospective Cohort Analysis From the Swedish Part of the International ERAS Database}, author = {Bjerregaard, Felix and Baloch, Naseer and Asklid, Daniel and Ljungqvist, Olle and Pekkari, Klas and Elliot, Anders H. and Gustafsson, Ulf O.}, year = {2025}, journal = {World Journal of Surgery}, volume = {49}, number = {4}, pages = {840--849}, doi = {10.1002/wjs.12535}, url = {1943188}, language = {eng}, publisher = {Springer}, keywords = {eras; colon surgery; risk factors in elderly}, abstract = {BACKGROUND: The growing proportion of older individuals worldwide is anticipated to lead to an increase in the number of elderly patients requiring surgery for colon cancer. Consequently, it is crucial to identify specific risk factors for mortality and complications after colon surgery in this age group.METHODS: The Swedish part of the ERAS registry (EIAS) between 2009 and 2022 was used. Patients aged ≥ 75 years undergoing colon surgery were compared with younger patients regarding risk factors for severe complications and mortality after multivariate regression analysis.RESULTS: After adjusting for potential confounders, three risk factors specifically associated with severe complications in elderly patients were identified: severe pulmonary disease (OR 1.64; 95% CI 1.04-2.58), recent immunosuppressive treatment (OR 1.92; 95% CI 1.12-3.30), and left hemicolectomy (OR 1.43; 95% CI 1.04-1.97). Furthermore, four risk factors for mortality, statistically significant only in the older age group, were found: male sex (OR 1.73; 95% CI 1.08-2.76), ASA ≥ 3 (OR 2.92; 95% CI 1.66-5.15), severe pulmonary disease (OR 2.28; 95% CI 1.02-5.06), and open surgery (OR 1.68; 95% CI 1.04-2.73).CONCLUSION: Several risk factors for severe complications and 30-day mortality specific to the elderly group were identified. Among these, severe pulmonary disease was associated with both severe complications and mortality.}, issn = {0364-2313} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stenbergerik_2025_2, title = {Risk for cancer after bariatric surgery compared with the general population : a nationwide matched cohort study}, author = {Stenberg, Erik and Ottosson, Johan and Cao, Yang and Lagstam, Ida and Näslund, Erik}, year = {2025}, journal = {Obesity}, volume = {33}, number = {9}, pages = {1725--1733}, doi = {10.1002/oby.24318}, url = {1988696}, language = {eng}, publisher = {John Wiley & Sons}, abstract = {Objective: Our objective was to evaluate how the incidence of cancer after metabolic and bariatric surgery (MBS) compared with the general population.Methods: A nationwide cohort of patients who underwent MBS in Sweden from 2007 to 2020 were matched (age, sex, area of residence) to controls from the general population. All patients were followed for new incidence of cancer.Results: Among the 68,424 patients who underwent MBS compared with the 640,944 controls, there was no difference in the risk for new onset of cancer (incidence rate ratio [IRR]: 1.03, 95% CI: 0.99-1.07). Compared with controls, MBS was associated with a lower risk for breast cancer in women (IRR: 0.78, 95% CI: 0.71-0.86) and nonmelanoma (IRR: 0.71, 95% CI: 0.59-0.85) and melanoma (IRR: 0.77, 95% CI: 0.68-0.87) skin cancer in men and women, but an increased risk remained for colon cancer, liver cancer, pancreatic cancer, corpus uteri cancer, renal cancer, malignant meningioma, and non-Hodgkin's lymphoma.Conclusions: All-cancer incidence risk was similar between patients who underwent MBS and the general population. Although breast and skin cancer risk was lower among MBS patients compared with controls, MBS patients had a greater risk for multiple cancer types. Thus, patients who have undergone MBS should continue recommended cancer screening and clinically approved work-up for cancer symptoms as recommended for the general population.}, issn = {1930-7381} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_katawazaiasmatullah_2025_4, title = {Risk for ventral hernia related to parity : a population-based register study}, author = {Katawazai, Asmatullah and Wallin, Göran and Sandblom, Gabriel}, year = {2025}, journal = {British Journal of Surgery}, volume = {112}, number = {Suppl. 11}, pages = {xi31--xi32}, doi = {10.1093/bjs/znaf149.113}, url = {1992705}, language = {eng}, publisher = {Oxford University Press}, abstract = {Introduction: Hernia of the linea alba (ventral hernia) is a common surgical condition that affects both men and women. The association between pregnancy and risk of developing ventral hernias is unclear. This study aimed to assess the risk of developing a primary ventral hernia requiring repair, and whether increasing parity is associated with a greater risk of developing a ventral hernia.Method: This nationwide cohort study included women born between 1950-1980 who were registered in the Swedish Medical Birth Register (MBR). Data on pregnancies and vaginal or caesarean sections were retrieved from the Birth Register. The cohort was cross-matched with the National Patient Register (NPR) to identify subsequent primary hernia repairs.Result: This study included 1,630,754 women born between 1950 and 1980. Among these, 1,588,609 (97.4%) were registered in MBR. The incidence rates for Umbilical Hernia Repair (UHR) and Epigastric Hernia Repair (EHR) were 13.2/100,000 person-years and 5.4 per 100,000 person-years, respectively. When compared with women registered for one delivery, the incidence rate ratio for UHR was higher among those with two deliveries (1.3, 95% CI: 1.26-1.33) and among those registered with ≥3 deliveries (1.6, 95% CI: 1.58-1.68).The incidence rate ratios were 1.29 (95% CI: 1.20-1.39) and 1.34 ( 95% CI: 1.24-1.45) for EHR among women with two and ≥3 registered deliveries, respectively.Discussion: A history of more than one pregnancy is associated with an increased incidence of umbilical and epigastric hernias. The incidence rate of UHR and EHR was higher in women who underwent caesarean delivery than in those who underwent vaginal delivery.}, issn = {0007-1323} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_katawazaiasmatullah_2025_5, title = {Risk for ventral hernia related to parity : A population-based register study}, author = {Katawazai, Asmatullah and Järnbert-Pettersson, Hans and Wallin, Göran and Sandblom, Gabriel}, year = {2025}, journal = {International journal of abdominal wall and hernia surgery}, volume = {8}, number = {2}, pages = {101--106}, doi = {10.4103/ijawhs.ijawhs_21_25}, url = {1985558}, language = {eng}, publisher = {Wolters Kluwer}, keywords = {epigastric hernia; linea alba; parity; pregnancy; umbilical hernia; ventral hernia}, abstract = {INTRODUCTION: The association between pregnancy and the risk of developing ventral hernias is unclear. This study aimed to assess the risk of developing a primary ventral hernia requiring repair and whether increasing parity is associated with a greater risk of developing a ventral hernia.MATERIALS AND METHODS: This nationwide cohort study included women born between 1950 and 1980 who were registered in the Swedish Medical Birth Register (MBR). Data on pregnancies and vaginal or cesarean sections were retrieved from the birth register. The cohort was cross-matched with the National Patient Register (NPR) to identify subsequent primary hernia repairs.RESULTS: This study included 1,630,754 women born between 1950 and 1980. Among these, 1,588,609 (97.4%) were registered in the MBR. The incidence rates for umbilical hernia repair (UHR) and epigastric hernia repair (EHR) were 13.2/100,000 person-years and 5.4 per 100,000 person-years, respectively. When compared with women registered for one delivery, the incidence rate ratio for UHR was higher among those with two deliveries (1.18, 95% CI:1.12-1.24) and among those registered with >= 3 deliveries (1.48 95% CI: 1.41-1.56). The incidence rate ratios were 1.29 (95% CI: 1.20-1.39) and 1.34 (95% CI: 1.24-1.45) for EHR among women with two and >= 3 registered deliveries, respectively.CONCLUSION: A history of more than one pregnancy is associated with an increased incidence of umbilical and epigastric hernias.}, issn = {2589-8736} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mitselouniki_2025, title = {Risk of asthma in individuals with eosinophilic esophagitis : Population-based cohort study with sibling analyses}, author = {Mitselou, Niki and Uchida, Amiko and Roelstraete, Bjorn and Melén, Erik and Garber, John J. and Ludvigsson, Jonas F.}, year = {2025}, journal = {Clinical and Translational Allergy}, volume = {15}, number = {6}, doi = {10.1002/clt2.70068}, url = {1966551}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {asthma; cohort; comorbidity; eosinophilic esophagitis}, abstract = {Introduction: There are limited data on the relationship between eosinophilic esophagitis (EoE) and asthma. We aimed to assess the risk of asthma in EoE patients compared with matched controls and siblings.Methods: Through the ESPRESSO study, a Swedish nationwide population-based histopathology cohort, we identified EoE patients diagnosed between 1989 and 2017 (n = 1146) and up to 5 age- and sex-matched controls (n = 5022). Cox regression generated hazard ratios (HRs) for developing asthma. We compared EoE patients with sibling controls.Results: The median age at EoE diagnosis was 42 years. During a median follow-up of 3.8 years, 140 EoE patients (28.1/1000 person-years) and 174 controls (7.2/1000 person-years) developed asthma (HR = 3.96; 95% confidence interval [CI] = 3.16-4.96, p < 0.001). An increased risk of asthma was seen in the first 10 years after EoE diagnosis but not thereafter. EoE patients diagnosed in childhood or young adulthood were at a particularly high risk of asthma (HR = 4.74; 95% CI = 2.93-7.67, p < 0.001 and HR = 5.84; 95% CI = 3.68-9.29, p < 0.001, respectively). Compared with their non-EoE siblings, EoE patients were at a 5-fold increased risk of asthma (HR = 4.97; 95% CI = 3.13-7.92, p < 0.001).Conclusion: EoE patients are at an increased risk of asthma compared with the general population, which is unlikely to be entirely explained through unmeasured intrafamilial factors given that the positive association remained in sibling analyses. Physicians caring for EoE should have a high awareness of concomitant asthma.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kujahalkolaralf_2025, title = {Risk of childlessness in help-seeking men with Peyronie's disease : A Swedish longitudinal study}, author = {Kuja-Halkola, Ralf and Henningsohn, Lars and Zietsch, Brendan and Larsson, Henrik and Cederlöf, Martin}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {1}, doi = {10.1371/journal.pone.0315948}, url = {1933307}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {Peyronie's disease (PD) is a disorder of the penis that is associated with poor mental health, lowered psychosocial- and sexual wellbeing, which may increase the risk of childlessness in men affected by the disorder. Although this is an issue of significant clinical importance, it has not been addressed in research to date. We conducted a longitudinal cohort study based on data from Swedish national registers utilizing a large sample of help-seeking men with PD, along with matched subjects from the general population. We assessed the probability and odds ratio of childlessness, modeled with logistic regressions, and offspring rate ratio, modeled with Poisson regression. We found that the probability of childlessness was somewhat lowered for men with PD aged between 35 and 71 years at end of follow-up. Men with PD aged 35 or less showed slightly elevated probabilities of childlessness. Specifically, odds ratios for childlessness were between 0.5 and 1.0 for men aged above 35, and between 1 and 1.5 for men aged less than 35, although the confidence intervals for increased odds partly included the null. Analyses of men's rate of offspring showed similar pattern, with higher rate ratios for older men and lower for younger men. Although more research is needed, the findings of this study suggest that clinical urological practice may be enhanced by a proactive discussions about the potential issue of childlessness in younger men with PD.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mavridisanastasios_2025, title = {Risk of Ischemic and Hemorrhagic Stroke in Individuals With Type 1 and Type 2 Diabetes : A Nationwide Cohort Study in Sweden}, author = {Mavridis, Anastasios and Viktorisson, Adam and Eliasson, Björn and von Euler, Mia and Sunnerhagen, Katharina S.}, year = {2025}, journal = {Neurology}, volume = {104}, number = {7}, doi = {10.1212/WNL.0000000000213480}, url = {1946266}, language = {eng}, publisher = {Wolters Kluwer}, abstract = {BACKGROUND AND OBJECTIVES: Diabetes significantly increases the risk of cardiovascular events, including stroke. Although the association with ischemic stroke is well established, the relationship with hemorrhagic stroke remains unclear. This study aimed to evaluate the risk of ischemic and hemorrhagic stroke in individuals with type 1 and type 2 diabetes compared with diabetes-free controls from the general population.METHODS: This cohort study included individuals with type 1 or type 2 diabetes from the Swedish National Diabetes Register between 2005 and 2019, matched to diabetes-free controls by age and sex. Data on baseline characteristics, comorbidities, medications, and outcomes were collected from multiple national registers. Stroke incidence rates and adjusted hazard ratios were estimated using Cox proportional hazard models, stratified by diabetes type, for ischemic and hemorrhagic stroke.RESULTS: The study included 47,720 individuals with type 1 diabetes (mean age 34.4, 44.8% female) and 686,158 with type 2 diabetes (mean age 65.3, 43.3% female), matched to 143,160 and 2,058,474 controls, respectively. In individuals with type 1 diabetes, the ischemic stroke risk was 2.54 times higher (95% CI 2.36-2.73) and the hemorrhagic stroke risk was 1.88 times higher (95% CI 1.57-2.26) compared with controls. In individuals with type 2 diabetes, the ischemic stroke risk was 1.37 times higher (95% CI 1.35-1.38) while the hemorrhagic stroke risk was not significantly increased (HR: 0.99, 95% CI 0.96-1.02). Higher HbA1c levels were associated with increased ischemic stroke risk for both diabetes types. For hemorrhagic stroke, individuals with type 1 diabetes had significantly higher risk starting at HbA1c > 52 mmol/mol while in those with type 2 diabetes, a modest risk increase was observed only at HbA1c > 72 mmol/mol.DISCUSSION: The risk of ischemic stroke was higher for both diabetes types. Individuals with type 1 diabetes also exhibited a higher risk of hemorrhagic stroke compared with diabetes-free controls while type 2 diabetes was significantly associated with risk of hemorrhagic stroke only when HbA1c was higher than 72 mmol/mol. These findings highlight the increased stroke risk in diabetes, with distinct patterns by stroke subtype and diabetes type. Tailored prevention strategies are essential to address these differences.}, issn = {0028-3878} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hggstrmchristel_2025, title = {Risk of upper urinary tract urothelial carcinoma after primary non-muscle-invasive urinary bladder cancer : A nationwide population-based cohort study}, author = {Häggström, Christel and Hagberg, Oskar and Holmberg, Lars and Hosseini, Abolfazl and Jerlström, Tomas and Ströck, Viveka and Söderkvist, Karin and Ullén, Anders and Liedberg, Fredrik and Jahnson, Staffan and Aljabery, Firas}, year = {2025}, journal = {BJUI Compass}, volume = {6}, number = {5}, doi = {10.1002/bco2.70021}, url = {1957047}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {cohort study; register‐based; surveillance; upper urinary tract urothelial carcinoma; urinary bladder cancer}, abstract = {OBJECTIVES: To investigate the risk of upper urinary tract urothelial carcinoma (UTUC) in patients with non-muscle-invasive bladder cancer (NMIBC), in relation to the primary NMIBC tumour risk categories, calendar time trends and intravesical Bacillus Calmette-Guerin (BCG) treatment.PATIENT AND METHODS: All patients with primary NMIBC diagnosed 1997-2019 registered in Bladder Cancer Data base Sweden (BladderBaSe) 2.0 were included in the study. Risk of UTUC was calculated by cumulative incidence proportion using competing risk analysis. Associations with risk of UTUC by tumour stage category, calendar time, and intravesical BCG treatment was estimated by hazard ratios from multivariable Cox regression analyses.RESULTS: Of 36 038 NMIBC patients, 537 (1.5%) were diagnosed with UTUC during a mean time of 7 years in follow-up. The risk of UTUC within 10 years from NMIBC diagnosis was 1.7% (95% 1.6-1.9) with highest estimates for TaG3/CIS. Stage T1 and TaG3/CIS, as compared with TaG1-2 was associated to risk, with stronger associations during later calendar times. Within high-risk NMIBC patients (CIS/TaG3/T1), intravesical BCG treatment was associated with higher risk of UTUC.CONCLUSIONS: This large study of more than 36 000 patients with NMIBC found 1.7% (95% 1.6-1.9) risk of UTUC within 10 years of diagnosis. Differences by tumour stage category indicate the need for refined studies accounting for tumour characteristics, location in the bladder and given treatment to optimise follow-up routines in NMIBC.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_quennerstedtmikael_2025, title = {Risky topics in health education : Enacted content when students with migration backgrounds meet Swedish health education}, author = {Quennerstedt, Mikael and Caldeborg, Annica and Barker, Dean and Varea, Valeria}, year = {2025}, journal = {European Educational Research Journal}, doi = {10.1177/14749041251388801}, url = {2014178}, language = {eng}, publisher = {Sage Publications}, keywords = {risk; health; content; migrant students}, abstract = {School health educational content often entails different subject areas and a variety of topics that students are supposed to learn, and when taught in diverse classrooms, potentially positions students as at-risk. Using vignettes in interviews with migrant students in Sweden, the study focuses on views of the content of health education in relation to different ways that health as risk is enacted. Four aspects of risk were identified: (i) risk as content in health education and risky, including topics such as nutrition, stress, smoking, and pollution; (ii) risk as content in health education but not so risky, including topics such as health care and disease prevention; (iii) not-so-risky topics in health education, including topics such as physical activity, physical health, and social relations; and (iv) not risk as content in health education but still risky, including topics related to sex education. Teachers in health education, regardless of school subject, should be aware that some topics position students as being at-risk, other topics put students at-risk even if the topics are not about risk per se, and lastly, that risk can be something with pedagogical potential if it is used purposefully and educationally.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_svenningssonanders_2025, title = {Rituximab long-term DOSE trial in Multiple Sclerosis - RIDOSE-MS : A phase 3 trial investigating extended dosing regimen of rituximab in relapsing-remitting MS}, author = {Svenningsson, Anders and Frisell, Thomas and Burman, Joachim and Salzer, Jonatan and Fink, Katharina and Hambraeus, Joakim and Malmestrom, Clas and Sundström, Peter and Lange, Niclas and Johansson, Rune and Mellergård, Johan and Rosenstein, Igal and Ahremark, Gustaf and Sjöblom, Irina and de Flon, Pierre and Piehl, Fredrik and Lycke, Jan}, year = {2025}, journal = {Multiple Sclerosis Journal}, volume = {31}, number = {Suppl. 3}, pages = {1338--1339}, url = {2038170}, language = {eng}, publisher = {Sage Publications}, abstract = {Introduction: In the RIFUND-MS trial (NCT02746744), we demonstrated a superior effect of rituximab (RTX) compared with dimethyl fumarate (DMF) for prevention of relapses and focal MRI activity in relapsing-remitting multiple sclerosis (RRMS). However, the optimal dosing regimen of RTX for optimization of the benefit-to-risk balance is not known.Objectives/Aims: To compare the efficacy and safety of an extended 12-month dosing regimen with a standard dosing with RTX. Every 6 months.Methods: The RIDOSE-MS trial was a rater-blinded randomized phase 3 trial comparing 500 mg RTX given 12-monthly with 500 mg 6-monthly over a 3-year period after an initial common 1-year with 6-monthly dosing. The primary outcome was non-inferiority of the extended dosing regimen regarding no evidence of disease activity (NEDA)-3: no relapses, no new or enlarging T2 MRI lesions and no confirmed disability worsening, over the 3-year randomized period. Secondary outcomes involved levels of biomarkers and immunological side effects, particularly decrease in immunoglobulin G (IgG) levels and development of hypogammaglobulinemia.Results: So far, data on relapses and MRI activity have been analyzed. A total of 207 individuals were randomized to each treatment arm, 104 to the 12-monthly and 103 to the 6-monthly arm. There were in total reported 12 protocol-defined relapses over the entire trial period of 4 years yielding an annual relapse rate of 0.015 for both arms combined. This is the same relapse rate as in the RTX arm of the previous RIFUND-MS trial, comparing RTX with DMF. Seven of these relapses occurred in the 6-monthly arm and five in the 12-monthly arm (p=0.5). In total 36 new lesions appeared in 22 unique patients (12 in the 12-monthly and 10 in the 6-monthly arm) during the whole trial period (p=0.7). Adverse events were equally distributed between the treatment arms. The reduction rate of IgG was approximately 25% slower in the 12-monthly compared with the 6-monthly group.Conclusion: The RIDOSE-MS trial shows that yearly treatment of 500 mg rituximab is highly effective and non-inferior to 6-monthly treatment for the inflammatory manifestations of MS. Although we did not see any signal of less infections in the extended dose arm, the lower decline on immunoglobulin levels might lead to long-term safety benefits from a lower accumulated dose over time.}, issn = {1352-4585} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_svenningssonanders_2025_1, title = {RItuximab long-term DOSE trial in Multiple Sclerosis - RIDOSE-MS. A rater-blinded randomized phase 3 trial comparing standard with extended dosing intervals of rituximab in relapsing-remitting MS}, author = {Svenningsson, Anders and Frisell, Thomas and Burman, Joachim and Salzer, Jonatan and Fink, Katharina and Hambraeus, Joakim and Malmeström, Clas and Sundström, Peter and Lange, Niclas and Johansson, Rune and Mellergård, Johan and Rosenstein, Igal and Ahremark, Gustaf and Sjöblom, Irina and de Flon, Pierre and Piehl, Fredrik and Lycke, Jan}, year = {2025}, journal = {Multiple Sclerosis Journal}, volume = {31}, number = {Suppl. 3}, pages = {75--76}, url = {2038163}, language = {eng}, publisher = {Sage Publications}, abstract = {Introduction: In the RIFUND-MS trial (NCT02746744), we demonstrated a superior effect of rituximab (RTX) compared with dimethyl fumarate (DMF) for prevention of relapses and focal MRI activity in relapsing-remitting multiple sclerosis (RRMS). However, the optimal dosing regimen of RTX for optimization of the benefit-to-risk balance is not known.Objectives/Aims: To compare the effect and safety of a standard RTX dosing interval of 6 months with dose interval extension to 12 months, with proportions fulfilling No Evidence of Disease Activity-3 (NEDA-3) during year 2 – 4 as primary endpoint (non-inferiority).Methods: The RIDOSE-MS trial (NCT03979456) is a rater-blinded randomized phase 3 trial comparing 500 mg RTX given 12-monthly with 500 mg 6-monthly over a 3-year period after an initial common 1-year with 6-monthly dosing. We used the following definition of NEDA-3: no relapses, no new or enlarging T2 MRI lesions and no confirmed disability worsening. Secondary outcomes included soluble biomarkers reflecting immunological side effects, particularly decrease in immunoglobulin G (IgG) levels, and rate of infections.Results: A total of 207 individuals were randomized to each treatment arm; 104 to the extended dosing, and 103 to the standard dosing arm. The last patient completed the trial in December 2024, and site closure is ongoing. We expect database lock in May 2025 and results of primary and key secondary endpoints available for presentation at the ECTRIMS meeting 2025. There were in total reported 12 protocol-defined relapses over the entire trial period of 4 years, yielding an annual relapse rate of 0.015 for both arms combined. This is the same relapse rate as in the RTX arm of the previous RIFUND-MS trial, comparing RTX with DMF. No new serious safety concerns emerged.Conclusion: The overall relapse rate was very low in the RIDOSE-MS trial, in which half of the participants were treated with an extended dosing regimen of RTX regardless of individual dynamics in the re-population of B cells. Since long-term safety mainly is related to the immunosuppressive properties of anti-CD20 therapies, it is important to investigate whether increased intervals between RTX infusions reduce risks while maintaining the efficacy of treatment. Primary endpoint data will be presented as well as key secondary endpoints.}, issn = {1352-4585} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vinayakpatilrajesh_2025_4, title = {Robots and Intelligent Agents for Product Creation and Manufacturing in Sustainable Digitalized Manufacturing Systems}, author = {Vinayak Patil, Rajesh and Löfstrand, Magnus}, year = {2025}, journal = {Advances in Mechanical Engineering}, url = {2018817}, language = {eng}, publisher = {Sage Publications}, issn = {1687-8132} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_salimim_2025, title = {Robust Few-Shot Semantic Segmentation for Blurred and Occluded Objects in Construction Environments}, author = {Salimi, M. and Loni, Mohammad and Cicchetti, A. and Sirjani, M.}, year = {2025}, doi = {10.1109/IJCNN64981.2025.11227444}, url = {2028707}, language = {eng}, publisher = {IEEE}, keywords = {adversarial attacks; construction; hyperparameter optimization; meta-learning; semantic segmentation}, abstract = {The increasing demand for autonomous machines in construction environments necessitates the development of robust object detection algorithms that can perform effectively across various weather and environmental conditions. However, challenging conditions at construction sites, such as mud splashes and vibrations, can degrade object detection performance by causing sensor occlusions and image blurriness. Traditional adversarial training methods, which enhance model robustness by using perturbed data, are limited in construction environments due to the scarcity of diverse real-world adversarial data and the dynamic nature of construction environments. To overcome these challenges, this paper explores utilizing few-shot learning (FSL) to improve the generalization performance and robustness of object detection models. FSL enables models to adapt quickly using minimal data, reducing the need for large datasets. In addition, we identify an often-overlooked issue: the hyperparameters used in FSL training are typically not optimized for this unique paradigm. To address this, we combine FSL with hyperparameter optimization to enhance model performance across multiple small-scale datasets. Experimental results demonstrate that our approach improves model performance on the ConstScene dataset over the default training paradigm. The code for this study is available at here.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_peinaixuan_2025, title = {Role of Glucocorticoids in Resolution of Granulocyte Colony Stimulating Factor-Induced Aortitis : 2 Cases and Review of the Literature}, author = {Pei, Naixuan and Borg, Alexander and Dani, Lara and Wiklander, Oscar P. B. and Parodis, Ioannis}, year = {2025}, journal = {European Journal of Rheumatology}, volume = {12}, number = {4}, doi = {10.5152/eurjrheum.2024.0137}, url = {2041980}, language = {eng}, publisher = {AVES}, keywords = {adverse events; aortitis; cancer; case report; g-csf; glucocorticoids}, abstract = {Recombinant human granulocyte colony-stimulating factor (G-CSF) is widely established as primary or secondary prophylaxis against neutropenia for patients undergoing chemotherapy. Despite the common side effects being generally mild, some rare but severe adverse events have been documented. In recent years, increasing numbers of G-CSF-induced aortitis have been reported worldwide. However, clinicians have not yet reached a consensus on the management and treatment of this condition. In this report, previously reported cases of G-CSF-induced aortitis in the literature are reviewed, and 2 additional independent cases are presented that share multiple common features regarding patient gender, age, G-CSF treatment regimen, imaging modalities for diagnosis, and disease course. In one of the cases, the patient was treated empirically with glucocorticoids, while in the other case, no specific treatment was given for the aortitis other than discontinuation of the G-CSF treatment. In both cases, improvement of symptoms and complete resolution of the inflammation were achieved about 1 month after the disease onset. Aortitis is a rare but severe adverse event of G-CSF therapy and should be suspected upon relevant complaints, prompting rapid investigation. Although empirical use of glucocorticoids appears efficient for the resolution of the inflammation and symptoms, no substantial differences in the disease course were obtained in comparison to spontaneous remission upon discontinuation of G-CSF.}, issn = {2147-9720} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_haczkiewiczmichal_2025, title = {Role of the cholinergic system in the psychopathology and treatment of schizophrenia : a protocol for a scoping review}, author = {Haczkiewicz, Michal and Hylén, Ulrika and Msghina, Mussie}, year = {2025}, journal = {Frontiers in Psychiatry}, volume = {16}, doi = {10.3389/fpsyt.2025.1593211}, url = {1972219}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {acetylcholine; cholinergic; cognition; emotion; motivation; schizophrenia; scoping review}, abstract = {INTRODUCTION AND OBJECTIVE: The cholinergic system has broad implications for affective and cognitive processes, which makes it pertinent for the psychopathology and treatment of mental disorders. Questions concerning its role in schizophrenia, a chronic disorder characterized by psychosis, emotional blunting and cognitive deficits, have been made particularly relevant due to the recent Food and Drug Administration (FDA) approval of a muscarinic agonist as an antipsychotic agent. The present paper details the protocol for a scoping review that will map models, evidence and research gaps concerning the role of the cholinergic system in the positive, negative and cognitive domains implicated in the psychopathology of schizophrenia.METHODS AND ANALYSIS: The scoping review will be conducted according to JBI (formerly the Joanna Briggs institute) methodology, using articles from the following databases: PubMed, Embase, Scopus, Cochrane Central Register of Controlled Trials and PsycInfo. Two independent reviewers will screen the articles using title and abstract, after which full text-analysis will determine inclusion. Only published original peer-reviewed English-language studies from the last 20 years that pertain to the review objective will be included. Clinical studies will be assessed for methodological quality and risk of bias. The results, which the reviewers will extract independently of each other using a data extraction tool, will be presented in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocol Extension for Scoping Reviews (PRISMA-ScR).DISCUSSION: Clarifying the research gaps in the field can indicate where future pre-clinical and clinical studies and systematic reviews can be worthwhile, and the risk of bias assessment aids in this by stratifying the included clinical trials according to quality. However, the language and publication date restrictions risk excluding relevant studies, which can introduce bias.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_burtonmurrayhelen_2025, title = {Rome Foundation Working Team Report : Consensus Statement on the Design and Conduct of Behavioural Clinical Trials for Disorders of Gut-Brain Interaction}, author = {Burton-Murray, Helen and Guadagnoli, Livia and Kamp, Kendra and Trindade, Ines and Powell, Lynda H. and Simrén, Magnus and Ljótsson, Brjánn and Keefer, Laurie}, year = {2025}, journal = {Alimentary Pharmacology and Therapeutics}, volume = {61}, number = {5}, pages = {787--802}, doi = {10.1111/apt.18482}, url = {1930039}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {orbit model; brain–gut behaviour therapy; clinical trials; disorders of gut–brain interaction; efficacy; minimum clinically important difference}, abstract = {BACKGROUND: Brain-gut behaviour therapies (BGBT) have gained widespread acceptance as therapeutic modalities for the management of disorders of gut-brain interaction (DGBI). However, existing treatment evaluation methods in the medical field fail to capture the specific elements of scientific rigour unique to behavioural trial evaluation.AIMS: To offer the first consensus on the development and testing of BGBT in DGBI.METHODS: An international, interdisciplinary team of experts developed a consensus statement heavily informed by best practice recommendations for behavioural clinical trials for chronic diseases, organised by a selected treatment development model.RESULTS: We suggest an existing behavioural treatment development model that has an iterative progression aligned with the drug development model with nuances specific to BGBT. We describe the iterative phases through initial discovery and experimental work, assembly of a mechanistic pathway and candidate treatment components, treatment refinement and optimisation, initial proof-of-concept, feasibility of clinical trials and, finally, confirmatory efficacy and effectiveness testing. We delineate recommendations for and provide examples that lend themselves to gastroenterologists planning to develop or test BGBT, reviewing proposals for or results from BGBT studies or writing management guidelines for DGBI.CONCLUSIONS: This working team report facilitates a shared understanding of the elements of scientific rigour necessary for BGBT development and could support future standards on which BGBT are evaluated in gastroenterology.}, issn = {0269-2813} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_adolfssonlarse_2025, title = {Rotator cuff surgery and semantics : definitions matter}, author = {Adolfsson, Lars E. and Lambert, Simon M. and Björnsson Hallgren, Hanna C.}, year = {2025}, journal = {Bone & Joint Open}, volume = {6}, number = {11}, pages = {1475--1478}, doi = {10.1302/2633-1462.611.BJO-2025-0205}, url = {2014098}, language = {eng}, publisher = {The British Editorial Society of Bone & Joint Surgery}, abstract = {The imprecise definition of terms used to describe pathological diagnosis in clinical medicine can lead to imprecise treatment concepts and inaccurate recording of outcomes. In this article, we explore the meaning of common terms applied to the pathology of the rotator cuff, and demonstrate how the imprecise use of words entails a risk of leading to a poor definition of the clinical condition being treated. We suggest improvements in the accuracy of the definition of what constitutes the rotator cuff. We suggest the use of 'defect' to describe the most common presentation of a degenerative lesion of the rotator cuff, rather than perpetuate the use of the term 'tear', which has a different, injurious aetiology. We suggest that the term 'repair' should be reserved for the condition in which an acutely injured tendon (with a 'tear') can be expected to heal, using the correct definition of the term 'to heal'. We recommend reserving the use of the term 'healed' for the condition of an acute lesion of the rotator cuff (a 'tear') to which the histological process of regenerating a near-normal enthesis can be reasonably applied. We further suggest that degenerative lesions ('defects') of the rotator cuff, which do not have the biological capacity to heal in the true sense when brought back to bone, should be described as having 'closure' of the defect.} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_torresanlia_2025_1, title = {Routledge International Handbook of Feminisms and Gender Studies : Convergences, Divergences, and Pluralities}, author = {Torres, Anália and Pinto, Paula Campos and Shefer, Tamara and Hearn, Jeff}, year = {2025}, doi = {10.4324/9781003253068}, url = {1922465}, language = {eng}, publisher = {Routledge}, keywords = {feminism; feminisms; academia; research}, abstract = {This Handbook is an important contribution to the recent history of and contemporary debates on feminist, gender, and women’s studies seen in a global perspective. It tackles current developments in the area by examining their multiple configurations in different countries across the world and taking stock of the tensions and controversies that have recently emerged against and within the field. The volume brings together essays from renowned feminist and gender studies academics from the Global North and Global South, together with early stage, emerging scholars. The diversity of the geopolitical and disciplinary locations and the quality of their reflections provide rich, wide-ranging, and interdisciplinary discussions that are rarely found in similar collections, making this an essential resource for advanced students and academics in the field.}, file = {https://oru.diva-portal.org/smash/get/diva2:1922465/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_edslevsofiemarie_2025, title = {rpoB mutations and their association with rifampicin resistance in clinical Staphylococcus epidermidis}, author = {Edslev, Sofie Marie and Aarris, Mia and Nielsen, Karen Leth and Hertz, Frederik B. and Johannesen, Thor Bech and Kolenda, Camille and Laurent, Frederic and Månsson, Emeli and Söderquist, Bo and Stegger, Marc}, year = {2025}, journal = {Journal of Antimicrobial Chemotherapy}, volume = {80}, number = {4}, pages = {1067--1071}, doi = {10.1093/jac/dkaf035}, url = {1935540}, language = {eng}, publisher = {Oxford University Press}, abstract = {BACKGROUND: Staphylococcus epidermidis is a ubiquitous member of the healthy skin and mucous microbiota but is also an opportunistic pathogen responsible for various infections, often treated with antibiotics like rifampicin. Resistance to rifampicin in S. epidermidis arises primarily through nonsynonymous mutations in the rpoB gene.OBJECTIVES: To investigate the prevalence of rpoB mutations and their association with phenotypic rifampicin resistance in clinical S. epidermidis isolates from Denmark, France, and Sweden.METHODS: All clinical isolates (N = 942) were whole-genome sequenced to identify mutations in rpoB and subsequently linked to phenotypic rifampicin resistance based on antimicrobial susceptibility testing.RESULTS: A total of 64 (6.8%) isolates were resistant to rifampicin. They carried all mutational changes in the rifampicin resistance-determining region (RRDR). Among 12 identified nonsynonymous mutations, 11 were exclusively observed in resistant strains, including novel mutations not previously described in S. epidermidis.CONCLUSIONS: This study highlights the diverse genetic variants of rpoB associated with rifampicin resistance in clinical S. epidermidis isolates, including novel mutations. The strong correlation between mutational changes in RRDR and phenotypic resistance reinforces the role of rpoB mutations as a primary mechanism of resistance in clinical isolates.}, issn = {0305-7453} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ervolaura_2025_4, title = {Rättslig kommunikation, domstolsförfaranden och konfliktlösning i förändring}, author = {Ervo, Laura}, year = {2025}, journal = {HumaNetten}, number = {55}, pages = {36--57}, doi = {10.15626/hn.20255503}, url = {2015791}, language = {swe}, publisher = {Fakulteten för Konst och Humaniora, Linnéuniversitetet} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_olssonkarl_2025, title = {Röster inifrån : Hur upplever GVI-kartlagda individer strategin och dess budskap?}, author = {Olsson, Karl and Frogner, Louise and Gustafsson, Nina-Katri and Hedlund, Anna and Ivert, Anna-Karin and Mellgren, Caroline and Starke, Mikaela and Hellfeldt, Karin}, year = {2025}, url = {2015999}, language = {swe}, publisher = {Institutionen för beteende-, social- och rättsvetenskap, Örebro universitet}, keywords = {gvi; group violence intervention; focused deterrence; ceasefire; pulling levers; call-in; notification meetings; gun violence; violent crime; gangs; criminal networks; procedural justice; legitimacy; policing; crime prevention; collaboration; interviews.; gruppvåldsintervention; fokuserad avskräckning; sluta skjut; skjutningar; dödligt våld; kriminella grupper; kriminella nätverk; kriminella miljöer; gängkriminalitet; processuell rättvisa; legitimitet; polisarbete; brottsförebyggande; brottsprevention; samverkan; intervjuer.}, abstract = {Denna kvalitativa studie undersöker hur Gruppvåldsintervention (eng. Group Violence Intervention, GVI), en strategi som syftar till att minska grovt våld kopplat till kriminella grupper, upplevs av individer som identifierats som gruppmedlemmar. Studien bygger på intervjuer med både mottagare av strategin och yrkesverksamma, och belyser erfarenheter av kartläggning, kommunikation, sanktioner och erbjudanden om stöd. Resultaten visar på varierade uppfattningar om strategins olika delar, där legitimitet och tillit framträder som centrala teman. Studien diskuterar hur processuell rättvisa, tydlig och respektfull kommunikation samt individuellt anpassat stöd påverkar hur GVI tas emot. Vidare lyfter studien utmaningar med att i arbetet med strategin förmedla grunderna för kartläggning och åtgärder, betonar vikten av timing, relevans och kontinuitet i stödinsatser, samt betydelsen av att balansera incitament för att avstå våld och avskräckande åtgärder mot våld. Sammantaget bidrar studien med nyanserade insikter om hur GVI fungerar i praktiken och erbjuder reflektioner kring hur strategin kan vidareutvecklas och förankras i både svensk och internationell kontext.;This qualitative study explores how Group Violence Intervention (GVI), a strategy aimed at reducing serious violence linked to criminal groups, is perceived and experienced by individuals identified as members of a such groups. Based on interviews with both recipients of the strategy and practitioners, the study examines experiences of identification, communication, enforcement, and offers of social support. Findings reveal varied perceptions of the strategy’s components, with legitimacy and trust emerging as central themes. The study discusses how procedural justice, clear and respectful communication, and individually tailored support influence how GVI is received and interpreted. Furthermore, it highlights challenges in communicating the rationale behind identification and enforcement actions, emphasizes the importance of timing, relevance, and continuity in support efforts, and underlines the need to balance incentives to abstain from violence with deterrent measures against violent behavior. Overall, the study contributes nuanced insights into how GVI functions in practice and offers reflections on how the strategy can be further developed and embedded in both Swedish and international contexts.}, file = {https://oru.diva-portal.org/smash/get/diva2:2015999/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kastorastavroulal_2025, title = {Safety of topical estrogen therapy during adjuvant endocrine treatment among patients with breast cancer : A meta-analysis based expert panel discussion}, author = {Kastora, Stavroula L. and Pantiora, Eirini and Hong, Yong Hwa and Veeramani, Meenakshi and Azim, Hatem A. and Chakrabarti, Rima and Geisler, Jürgen and Knoop, Ann and Lambertini, Matteo and Linderholm, Barbro and Meattini, Icro and Partridge, Ann H. and Vaz-Luis, Ines and Vorburger, Denise and Yongue, Gabriella and Karakatsanis, Andreas and Valachis, Antonios}, year = {2025}, journal = {Cancer Treatment Reviews}, volume = {133}, doi = {10.1016/j.ctrv.2025.102880}, url = {1931532}, language = {eng}, publisher = {Elsevier}, abstract = {IMPORTANCE: Endocrine treatments, such as Tamoxifen (TAM) and/or Aromatase inhibitors (AI), are the adjuvant therapy of choice for hormone-receptor positive breast cancer. These agents are associated with menopausal symptoms, adversely affecting drug compliance. Topical estrogen (TE) has been proposed for symptom management, given its' local application and presumed reduced bioavailability, however its oncological safety remains uncertain.OBJECTIVE: The present systematic review, meta-analysis and expert panel review aimed to evaluate the strength of the available evidence on the risk of recurrence and mortality when TE is utilised in congruence with TAM or AI treatment, among BC survivors.DATA SOURCES: Six databases and two prospective registers, were interrogated from inception to January 3rd, 2024. Search terms were Breast cancer AND Hormone replacement therapy AND topical/vaginal oestrogen AND recurrence/mortality.STUDY SELECTION: All study designs reporting the use vs. non-use of TE in breast cancer survivors receiving adjuvant endocrine treatment were included. Six observational studies were deemed eligible for inclusion. DATA EXTRACTION AND SYNTHESIS: Sources of heterogeneity were explored using subgroup analysis by risk of bias, median follow-up period, node positivity and menopausal status. Trial sequential analysis was performed to quantify outcome reliability. A global expert panel was called to deliberate on the data, pinpoint areas of limited understanding, and determine the most important areas for future research.MAIN OUTCOMES AND MEASURES: Risk ratio effect sizes (RR) and corresponding 95 % Confidence Intervals (CI) of breast cancer recurrence and mortality in survivors on endocrine treatment (TAM and/or AI) exposed to TE were reported. Expert panel appraisal of meta-analysis evidence with definition of current knowledge gaps and future research aims.RESULTS: In 38 050 female patients receiving adjuvant endocrine treatment, of whom 1805 had been exposed to TE, TE exposure of those on AI, did not increase all-cause mortality (RR 0.99 [95 %CI 0.58, 1.69], I2 = 81 %, P = 0.96; moderate GRADE certainty). However, such exposure may convey an increased risk of recurrence (RR 2.51 [95 % CI 1.10, 5.72], I2 = 9 %, P = 0.03; low-GRADE certainty). Exposure to TE during TAM did not increase either recurrence risk or all-cause mortality. Clinical factors such as lymph node positivity at the time of diagnosis and menopausal status and follow-up time appeared to be significant confounders.CONCLUSIONS AND RELEVANCE: The use of TE does not appear to increase either recurrence or mortality risk among BC survivors treated with TAM. An increased recurrence risk, without an increase in mortality, cannot be ruled out when TE is used during AI.}, issn = {0305-7372} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_isakssonsebastian_2025, title = {Same scale, different names? An assessment of the psychometric properties of three established scales that measure cognitive processes in insomnia, and the introduction of the sleep worry 7 questionnaire}, author = {Isaksson, Sebastian and Henriksson, Vera and Salim, Osame and Bäccman, Charlotte and Norell, Annika}, year = {2025}, journal = {Sleep Medicine}, volume = {133}, doi = {10.1016/j.sleep.2025.106595}, url = {1969848}, language = {eng}, publisher = {Elsevier}, keywords = {insomnia; sleep; cognition; anxiety; arousal; psychometric study; sleep initiation and maintenance disorders}, abstract = {Background: Previous reports have highlighted the abundance of cognitive constructs in insomnia research as a growing issue. Several questionnaires that measure sleep-related cognitions have been developed and there are indications of conceptual overlap between different cognitive constructs and the questions used to operationalize them.Objectives: This study examines the convergent validity of three established questionnaires measuring cognitive processes in insomnia: the Anxiety and Preoccupation about Sleep Questionnaire (APSQ), the Dysfunctional Beliefs and Attitudes about Sleep Scale (DBAS-10), and the Pre-Sleep Arousal Scale (PSAS-C). Another objective was to explore how a briefer scale can be structured as well as to investigate this scale's ability to predict incident and persistent insomnia compared to the established scales.Methods: 2333 participants from the general population completed surveys on insomnia symptoms and cognitive processes at baseline and 18 months later. Confirmatory factor analysis was used to investigate the scales' conceptual overlap as well as distinctive factors. An exploratory factor analysis was conducted to investigate the underlying factor structure of the items from the APSQ, the DBAS-10 and the PSAS-C. This analysis formed the basis of the creation of a new short scale: Sleep Worry 7. Binary logistic regressions were used to assess all scales' abilities to predict incident and persistent insomnia.Results and conclusions: The overlap between the three scales was neither large enough to conclude that they are measuring the same construct, nor could it be confirmed that they measure three distinct questionnaire-specific cognitive processes within insomnia. The brief scale created within this study was able to predict persistent insomnia at similar levels to the three established scales combined, indicating that it captures important cognitions involved in the maintenance of insomnia. Measuring sleep-related cognitions with fewer items might be beneficial in both clinical contexts and research.}, issn = {1389-9457} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_swaminathanchittaranjansrinivas_2025, title = {Sampling functions for global motion planning using Maps of Dynamics for mobile robots}, author = {Swaminathan, Chittaranjan Srinivas and Kucner, Tomasz P. and Lilienthal, Achim J. and Magnusson, Martin}, year = {2025}, journal = {Robotics and Autonomous Systems}, volume = {194}, doi = {10.1016/j.robot.2025.105117}, url = {2006368}, language = {eng}, publisher = {Elsevier}, keywords = {motion planning; path planning; dynamic environments; pedestrian; maps of dynamics; human motion patterns; sampling-based motion planning}, abstract = {Motion planning for mobile robots in dynamic environments shared with people is challenging. In a typical hierarchical planning framework, robots use a global planner for overall path-finding and a local planner for immediate adjustments to the path. Without considering the typical patterns of motion of dynamic entities, the global planner might generate paths that lead the robot into highly congested areas, where it is forced to wait, replan or manoeuvre around dynamic obstacles. Maps of Dynamics (MoDs) are a way to mitigate these issues. MoDs represent patterns of motion exhibited by moving entities in the environment, using probabilistic models. The use of MoDs in cost functions for motion planning enables a robot to plan motions that consider the motion patterns encoded in the MoDs. In previous work, it has been shown that the use of MoDs in the cost function helps generate more efficient paths, i.e., paths that lead to the robot and pedestrians spending less time waiting for each other. It has also been shown that using MoDs in the sampling step of sampling-based motion planning is beneficial to a mobile robot since it can result in reduced computation time by explicitly guiding the sampling process using information encoded in MoDs. However, existing work on the use of MoDs in the sampling process is limited. Correspondingly, an analysis of the performance of sampling heuristics for MoDs is also largely lacking. Since such an analysis is crucial to understand the effectiveness of MoDs in a practical setting, we ask the research question: can we obtain reasonably low-cost solutions using sampling-based motion planners that consider the flow of dynamic entities, in a reasonable amount of time. In this paper, we propose substantial improvements to two existing sampling heuristics: the Dijkstra-graph sampling (DGS), previously restricted to a specific type of MoD is extended to use any MoD; and the intensity-map (normalized number of observations of dynamic entities in each grid cell) is utilized more effectively by using importance sampling instead of rejection sampling. We show that an ellipsoidal heuristic can also be used with MoDs. We experimentally validate several sampling heuristics on two different sampling-based motion planners and present a comprehensive evaluation (52800 runs) of their performance on real-world data from densely populated environments. We conclude that reasonably cost solutions can be quickly obtained using a combination of the sampling heuristics within practically feasible time limits. Using the RRT* planner with our proposed MoD-aware, Dijkstra-graph-based heuristic yields approximate to 5%, %10 and 12% higher success rates after 2, 4 and 8 s of planning respectively, compared to uniform sampling, the baseline.}, issn = {0921-8890} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_14, title = {Samtida marxistisk teori}, author = {Johansson Wilén, Evelina and Schack, Lotte and Wilén, Carl and Örestig Kling, Johan}, year = {2025}, url = {2000843}, language = {swe}, publisher = {Daidalos}, abstract = {Efter decennier av nyliberal dominans och i kölvattnet av återkommande ekonomiska, sociala och ekologiska kriser har marxismen åter trätt fram som en gravitationspunkt för den samtida samhällsdebatten. Det växande behovet av verktyg för att förstå och utmana kapitalismens alltmer instabila ordning har drivit fram en global renässans för den marxistiska teorin – även i Sverige, där forskare, intellektuella och aktivister bidrar till dess utveckling.I "Samtida marxistisk teori" presenteras trettiosju tänkare från olika delar av världen, tänkare som har fört den marxistiska teorin in i det krisdrabbade 2000-talet. På vilka sätt kan det traditionella idéarvet utvecklas, omformuleras och aktiveras i en tid då den breda vänstern förlorar mark till den inflytelserika koalitionen mellan techmiljardärer och auktoritära ledare, framburna av nykonservativa, antifeministiska och fascistiska rörelser? Och vilka verktyg krävs egentligen för att kunna visualisera och frammana en annan ordning än den nyliberalism som nu bryter samman?Den här boken riktar sig till dem som möter marxistisk teori för första gången men även till dem som vill bredda sin förståelse av vad den kan betyda idag.Följande författarskap presenteras i boken:SAMIR AMIN, KEVIN B.ANDERSON, JAIRUS BANAJI, STEFANIA BARCA, GARGI BHATTACHARYYA, ROBERT BRENNER, MARTHA CAMPBELL, VIVEK CHIBBER, BRETT CHRISTOPHERS, TERRY EAGLETON, SILVIA FEDERICI, NANCY FRASER, RUTH WILSON GILMORE, RAMÓN GROSFOGUEL, DAVID HARVEY, MICHAEL HEINRICH, RAHEL JAEGGI, BOB JESSOP, ANNA G.JÓNASDÓTTIR, DOMENICO LOSURDO, DAVID MCNALLY, ANGELA MCROBBIE, SANDRO MEZZADRA & BRETT NEILSON, CHINA MIÉVILLE, DON MITCHELL, ANTONIO NEGRI, MOISHE POSTONE, KRISTIN ROSS, KOHEI SAITO, ANWAR SHAIKH, BEVERLY J.SILVER, BEVERLY SKEGGS, LISE VOGEL, IMMANUEL WALLERSTEIN, ELLEN MEIKSINS WOOD, ERIK OLIN WRIGHT, SLAVOJ ŽIŽEK} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lahgazimohamedjaouad_2025, title = {SBp-UNet : balancing efficiency and accuracy in CNNs with application to pedestrian segmentation}, author = {Lahgazi, Mohamed Jaouad and Mohaoui, Souad and Hakim, Abdelilah and Argoul, Pierre}, year = {2025}, journal = {EURASIP Journal on Image and Video Processing}, volume = {2025}, number = {1}, doi = {10.1186/s13640-025-00667-2}, url = {2014142}, language = {eng}, publisher = {Springer}, keywords = {cnn compression; fire units; feature reuse; bypass connections; semantic segmentation; pedestrian segmentation}, abstract = {This paper introduces a novel approach to balance the accuracy and efficiency in Convolutional Neural Networks (CNNs). The main contribution is a dual strategy that exploits feature reuse along a squeezed architecture. The idea is to integrate fire units from the SqueezeNet architecture, replacing standard convolutions to reduce the number of trainable parameters, and introducing data reuse through additional bypass connections to maintain accuracy. While the idea can be broadly applicable, we demonstrate its effectiveness by applying it to the UNet architecture, leading to the development of a novel network called Squeeze-Bypass-UNet (SBp-UNet). The network is therefore used for the challenging task of pedestrian semantic segmentation, particularly in scenarios involving heavy occlusions. We validate our model on the Occluded Human (OCHuman) dataset, demonstrating superior performance to the original UNet with 9.33 times fewer parameters. Further validation on the Pascal VOC dataset confirms the robust predictive ability of SBp-UNet. Our work thus offers a novel solution for the efficiency-accuracy problem in CNNs, with proven application in pedestrian segmentation.}, issn = {1687-5176} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_fanhan_2025, title = {Scalable AI-assisted identification of math support needs for first graders}, author = {Fan, Han and Lilienthal, Achim J. and Baumanns, Lukas and Pitta-Pantazi, Demetra and Christou, Constantinos and Schindler, Maike}, year = {2025}, pages = {248--248}, url = {2027418}, language = {eng}, publisher = {IGPME}, abstract = {Early identification of mathematical difficulties of young learners is critical for their individual development, yet traditional assessments such as standardized tests or diagnostic interviews face challenges, e.g., in scalability and practicality. To address these challenges, we developed an AI-assisted, pedagogical domain-informed digital tool, DIDUNAS, to evaluate first graders’ individual skill profiles and identify their need for support. As our research question we ask, How accurately can AI identify first graders' need for support in mathematics?Our study involved 290 students from 8 European schools (in Germany & Cyprus). The participants included multilingual students, students with disabilities, and diverse socioeconomic backgrounds. We used the ZAREKI-K standardized test (von Aster et al., 2009) as the ground truth of the students’ mathematical skill profiles. The test results indicated whether a student needed support or not. In our study, 71 students were identified as being in need of support in mathematics.For developing the digital tool, we first let 55 students engage with 12 digitally presented mathematical activities (e.g., number line, quantity comparison, etc.) designed by pedagogical experts, and take individual standardized ZAREKI-K tests. We assessed both results with machine learning techniques to have an insight about which tasks contributed most to accurate identification of support needs based on students' errors in each task. The analysis allowed us to refine the assessment to just 10 tasks. The AI-assisted DIDUNAS app with the refined task set was validated with 235 students, and it was able to identify students in need of support with 85% accuracy with a much less time consumption compared to one-by-one diagnostic interviews.Our results demonstrate that AI can enhance scalability for accurately identifying first graders’ need for support in mathematics. We use the results from the digital app DIDUNAS, which runs on typical tablet computers and PCs, to support teachers with overviews over their students’ skill profiles and needs for support. Future work will explore real-time adaptive feedback to improve user experience, longitudinal studies to assess long-term learning outcomes and applications across additional grade levels.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_golovchanovanadezhda_2025_1, title = {School absenteeism, pain, stress, and work disability : Lifelong associations from childhood to retirement age}, author = {Golovchanova, Nadezhda and Bergbom, Sofia and Owiredua, Christiana and Boersma, Katja}, year = {2025}, url = {2018567}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nielsenwils_2025, title = {Scoping literature review to identify candidate domains for the OMERACT Systemic Lupus Erythematosus core outcome set}, author = {Nielsen, Wils and Parodis, Ioannis and Touma, Zahi}, year = {2025}, journal = {Seminars in Arthritis & Rheumatism}, volume = {72}, doi = {10.1016/j.semarthrit.2025.152684}, url = {1943206}, language = {eng}, publisher = {Elsevier}, keywords = {core domain set; domains; literature review; systemic lupus erythematosus}, abstract = {OBJECTIVE: To identify candidate Systemic Lupus Erythematosus (SLE) domains from the literature for consideration towards the development of the SLE Core Outcome Set.METHODS: This was a comprehensive scoping literature review of SLE clinical trials and systematic reviews published since 2010. Studies were identified from 5 databases and were screened for eligibility. Candidate domains were extracted from the included studies. Candidate domains were winnowed and binned by the Outcome Measures in Rheumatology (OMERACT) SLE Advisory Group.RESULTS: Of the 4063 studies identified, 507 met inclusion criteria and proceeded to data extraction. Multiple domains and items were extracted, which winnowing and binning reduced to 25 candidate domains.CONCLUSION: The 25 candidate domains cover the important aspects of SLE and the 4 core areas of disease impact according to OMERACT framework. The 25 candidate domains constitute a feasible and manageable number of domains to proceed with to the core domain consensus stage that covers the wide range of impact of SLE. The candidate domains will be supplemented by ongoing qualitative research with patients living with SLE to identify additional domains before proceeding to the consensus stage.}, issn = {0049-0172} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alijagicandi_2025_4, title = {Sea urchin immune cells and associated microbiota co-exposed to iron oxide nanoparticles activate cellular and molecular reprogramming that promotes physiological adaptation}, author = {Alijagic, Andi and Russo, Roberta and Scuderi, Viviana and Ussia, Martina and Scalese, Silvia and Taverna, Simona and Engwall, Magnus and Pinsino, Annalisa}, year = {2025}, journal = {Journal of Hazardous Materials}, volume = {485}, doi = {10.1016/j.jhazmat.2024.136808}, url = {1920312}, language = {eng}, publisher = {Elsevier}, keywords = {nano-immune research; innate immunity and bacterial community; immune cell/bacteria co-culture; advanced cellular system; high-throughput approach}, abstract = {The innate immune system is the first player involved in the recognition/interaction with nanomaterials. Still, it is not the only system involved. The co-evolution of the microbiota with the innate immune system built an interdependence regulating immune homeostasis that is poorly studied. Herein, the simultaneous interaction of iron-oxide nanoparticles (Fe-oxide NPs), immune cells, and the microbiota associated with the blood of the sea urchin Paracentrotus lividus was explored by using a microbiota/immune cell model in vitro-ex vivo and a battery of complementary tools, including Raman spectroscopy, 16S Next-Generation Sequencing, high-content imaging, NanoString nCounter. Our findings highlight the P. lividus immune cells and microbiota dynamics in response to Fe-oxide NPs, including i) morphological rearrangement and immune cell health status maintenance (intracellular trafficking increasing, no phenotypic alterations or caspase 3/7 activation), ii) transcriptomic reprogramming in immune cells (Smad6, Lmo2, Univin, suPaxB, Frizzled-7, Fgfr2, Gp96 upregulation), iii) immune signaling unchanged (e.g., P-p38 MAPK, P-ERK, TLR4, IL-6 protein level unchanged), iv) enrichment in extracellular vesicle released in the co-culture medium, and v) a shift in the composition of microbial groups mainly in favor of Gram-positive bacteria (e.g., Firmicutes, Actinobacteria),. Our findings suggest that Fe-oxide NPs induce a multilevel immune cell-microbiota response restoring homeostasis.}, issn = {0304-3894} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ricartemarina_2025, title = {Season Project presentation : How will climate change affect the risk associated with sediments contaminated with organic and inorganic pollutants?}, author = {Ricarte, Marina and Aro, Rudolf and Geuer, Jana and Larsson, Maria and Scherbak, Nikolai and Sjöberg, Viktor and Karlsson, Stefan and Ericson Jogsten, Ingrid and Keiter, Steffen}, year = {2025}, journal = {Toxicology Letters}, volume = {411}, number = {Suppl.}, pages = {S106--S106}, doi = {10.1016/j.toxlet.2025.07.277}, url = {2004665}, language = {eng}, publisher = {Elsevier}, abstract = {Climate change is driving extreme weather patterns, leading to prolonged droughts and more frequent intense precipitation events. These environmental changes will impact aquatic systems by altering essential water quality parameters such as temperature, redox potential, pH, suspended solids and organic matter, which influence pollutant solubility and determine ecosystem health as well as drinking water production. In this context, sediments play a crucial role as they represent both a sink and source of pollutants. Therefore, sediment toxicity testing is essential for accurate environmental risk assessments. However, there remains a gap regarding comprehensive sediment testing ap-proaches that integrate multiple biomarker responses.The SEASON project uses an interdisciplinary approach combining strategies of environmental toxicology, analytical chemistry, andhydro geochemistry. The aim is to develop conceptual models for evaluating, understanding and predicting the impact of climate change effects on the fate, bioavailability, and toxicity of pollutants in the aquatic environment. This project focuses on risks associated with sediments contaminated by organic and inorganic pollutants, specifically metals and PFAS (per- and polyfluoroalkyl substances). By studying factors such as temperature, pH, microbial communities, and sediment-water interactions, the project seeks to understand how different climate change aspects affect pollutant behavior in aquatic ecosystems.The project consists of four sub-projects. Three investigate different chemical groups and mixtures under varying water conditions, using zebrafish (Danio rerio) as the main model organism. These studies will include in vitro and in vivo assays, microcosm experiments, microbiome studies and chemical analyses. The fourth subproject will integrate the results to develop a predictive model for sediment risk assessment.Sediment contact assays will be performed to evaluate the effects of contaminated samples on zebrafish embryos by measuring teratogenicity, developmental toxicity, behavioral changes, and gene expression. In microcosm studies, we will vary pH and mimic increased precipitation events to assess pollutant toxicity in adult zebrafish including sex-related toxicity differences, reproduction, and behavior. Effect-directed analysis (EDA) will be used to identify key toxicants in the samples. Microbiome analysis using metagenomic sequencing will focus on how contaminated sediments alter bacterial communities, which in turn can affect pollutant distribution and bioavailability. Chemical analyses will quantify PFAS, metals, and their speciation throughout the study. Ultimately, the project will integrate these data to develop models that increase our understanding of the impact of climate change on sediment contamination and aquatic ecosystem health.}, issn = {0378-4274} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindberglucasalexander_2025, title = {Seasonal variations in ventricular repolarization and tachyarrhythmias in hibernating brown bears (Ursus arctos arctos)}, author = {Lindberg, Lucas Alexander and Fuchs, Boris and Evans, Alina Lynn and Laske, Timothy and Björkenheim, Anna and Fröbert, Ole and Gottlieb, Lisa Amalie}, year = {2025}, journal = {Physiological Reports}, volume = {13}, number = {17}, doi = {10.14814/phy2.70531}, url = {1994552}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {qt interval; brown bear; electrocardiography; electrophysiology; hibernation; ventricular tachyarrhythmias}, abstract = {In humans, hypothermia prolongs ventricular repolarization and associates with sustained ventricular tachyarrhythmias. In bears, body temperature drops during hibernation similar to moderate human hypothermia, yet they rarely face fatal outcomes during the winter. This suggests protective adaptations in bear electrophysiology. We studied seasonality in ursine ventricular repolarization by analyzing >1 year electrocardiogram (ECG) recordings from loop recorders implanted in 57 free-ranging Eurasian brown bears. In sinus rhythm, bears exhibited significantly longer RR, QT, and Tpeak-Tend intervals (2441 ± 470, 508 ± 50, and 53 ± 8 ms, respectively) during hibernation than in the active period (649 ± 323, 232 ± 39, and 29 ± 5 ms, respectively). Optimal heart rate correction of QT interval (QT/RR0.435) demonstrated significant prolongation during hibernation. QT and Tpeak-Tend intervals remained longer during hibernation than in the active period, even when comparing ECGs with similar RR intervals in the two periods. Ventricular fibrillation occurred in four bears shot during licensed hunting in summer, which led to death. In conclusion, seasonal variations in ventricular repolarization in bears appear, at least partially, independently of heart rate. Compared to humans, ventricular repolarization is slower but more homogeneous. These findings, combined with the absence of fatalities during hibernation, support the theory of protective electrophysiological adaptations in bears. Insights into the underlying mechanisms have biomimetic potential for human therapy.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_liewlittorinmarkus_2025, title = {Second- and Third-Line Salvage Chemotherapy Followed by Allogeneic Stem Cell Transplantation Leads to High Survival Rates in Primary Refractory AML-A Population-Based Study}, author = {Liew-Littorin, Markus and Deleskog-Spångberg, Linn and Deneberg, Stefan and Janosi, Judit and Lazarevic, Vladimir and Nilsson, Gustav and Papageorgiou, Aristea and Robelius, Anna and Vennström, Lovisa and Juliusson, Gunnar and Uggla, Bertil and Höglund, Martin and Lehmann, Soren}, year = {2025}, journal = {European Journal of Haematology}, volume = {115}, number = {4}, pages = {423--432}, doi = {10.1111/ejh.70009}, url = {1988631}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {acute; leukemia; myeloid; refractory; retrospective study}, abstract = {Refractory acute myeloblastic leukemia (AML) is poorly studied. In this study, we characterized primary refractory AML and investigated treatment and outcome in a population-based setting. Based on all AML patients receiving intensive induction therapy at 12 Swedish hospitals from 2011 to 2018 (N = 1221), we identified 306 patients that failed to achieve composite complete remission (CRc) after first-line therapy. Two-hundred-sixteen (71%) of these patients received salvage treatment with intensive chemotherapy (ICT), of which 126 (58%) achieved CRc and 85 (39%) underwent allogeneic stem cell transplantation (HSCT). One- and 3-year overall survival (OS) in patients receiving salvage ICT were 56.8% and 28.9%, respectively. Secondary AML and adverse ELN risk were associated with worse OS after salvage ICT, while fludarabine-based FAIDA versus amsacrine-based ACE salvage and HSCT were associated with better OS. Three-year OS after first or second salvage chemotherapy, followed by HSCT were 55% and 71%, respectively. Refractory patients responding to salvage ICT showed only a nonsignificant trend toward inferior OS compared to patients in CRc after the first cycle. In conclusion, refractory AML patients eligible for further intensive therapy have a reasonable chance of obtaining remission and long-term survival when followed by HSCT. The results can serve as a basis for evaluation of new treatments in refractory AML.}, issn = {0902-4441} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_abuishkheidemimadeddin_2025_1, title = {Secondary ocular hypertension as an adverse effect of treatment with intravitreal dexamethasone implant : A retrospective Swedish cohort study}, author = {Abu Ishkheidem, Imadeddin and Breimer, Martin and Kamal, Saba and Zetterberg, Madeleine and Al-Hawasi, Abbas and Andersson Grönlund, Marita}, year = {2025}, journal = {Acta Ophthalmologica}, volume = {103}, number = {6}, pages = {699--706}, doi = {10.1111/aos.17475}, url = {1943008}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {diabetic macular oedema; intraocular pressure; intravitreal dexamethasone implant; ocular hypertension; retinal vein occlusion}, abstract = {PURPOSE: To evaluate the incidence and risk factors for secondary ocular hypertension (SOHT) following intravitreal dexamethasone implants (Ozurdex®) in patients with diabetic macular oedema (DME) and macular oedema secondary to retinal vein occlusion (RVO) in a Swedish cohort.METHODS: This retrospective study included 309 eyes from 249 patients treated with Ozurdex® at Sahlgrenska University Hospital, Mölndal, Sweden, from 1 January 2016 to 31 December 2023. Electronic medical records were reviewed for data including patient demographics, number of injections, incidence of and treatment modalities for SOHT and rate of Ozurdex® discontinuation.RESULTS: Of the 309 eyes, 217 (70.2%) were in the DME group and 92 (29.8%) in the RVO group. Overall, 117 eyes (37.9%) developed SOHT (intraocular pressure (IOP) ≥25 mmHg or a rise of ≥10 mmHg from baseline); this included 77 of 217 DME eyes (35.5%) and 40 of 92 RVO eyes (43.5%). Men were more than twice as likely as women to develop SOHT (adjusted odds ratio [aOR]: 2.53, p < 0.001). Each unit increase in baseline IOP was associated with an 8% increase in the odds of SOHT (aOR: 1.08 p = 0.025). Of all eyes, 30.5% received IOP-lowering treatment, primarily prostaglandins. None required invasive surgery.CONCLUSION: Our finding that 30.5% of eyes received IOP-lowering treatment confirms that SOHT is a prevalent complication following intravitreal dexamethasone implants. Male gender and higher baseline IOP were key indicators for developing SOHT after Ozurdex® treatment, emphasizing the need for vigilant monitoring. Most cases were managed with IOP-lowering eye drops, indicating that while common, SOHT is typically manageable without invasive interventions.}, issn = {1755-375X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_giarettaalberto_2025, title = {Security and privacy in virtual reality : a literature survey}, author = {Giaretta, Alberto}, year = {2025}, journal = {Virtual Reality}, volume = {29}, number = {1}, doi = {10.1007/s10055-024-01079-9}, url = {1924164}, language = {eng}, publisher = {Springer}, keywords = {virtual reality (vr); privacy; security; cybersecurity; authentication}, abstract = {Virtual reality (VR) is a multibillionaire market that keeps growing, year after year. As VR is becoming prevalent in households and small businesses, it is critical to address the effects that this technology might have on the privacy and security of its users. In this paper, we explore the state-of-the-art in VR privacy and security, we categorise potential issues and threats, and we analyse causes and effects of the identified threats. Besides, we focus on the research previously conducted in the field of authentication in VR, as it stands as the most investigated area in the topic. We also provide an overview of other interesting uses of VR in the field of cybersecurity, such as the use of VR to teach cybersecurity or evaluate the usability of security solutions.}, issn = {1359-4338}, file = {https://oru.diva-portal.org/smash/get/diva2:1924164/FULLTEXT01.pdf} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_kimansung_2025_1, title = {Seeds of change for plant-based food consumption : Products, restaurants and everyday life}, author = {Kim, Ansung}, year = {2025}, url = {2002309}, language = {eng}, publisher = {Örebro University}, keywords = {food choice; consumers; behaviour change; influence}, abstract = {The contemporary food system is no longer just a matter of nourishment; it has become a mirror reflecting the ecological, social and psychological tensions of our time. The manner in which we produce and consume food is intricately linked to a number of the most pressing challenges facing society, including climate change and rising health issues. The significance of dietary choices is becoming increasingly evident, with the heart of the matter being why people eat what they do and how people's food choices can be changed. This dissertation explores the role of hedonic and social factors in shaping the adoption of sustainable food choices by exploring three themes: Products, Restaurants and Everyday life. Each theme is explored through a combination of different methodological approaches, including consumer sensory evaluation, field experimentation and a randomised controlled trial enriched with social network analysis.The findings collectively highlight the need for multi-level strategies, which must integrate psychological, social and situational factors in order to be effective. While consumer preferences for the sensory attributes of plant-based meat alternatives differ depending on consumer psychographics (i.e. meat attachment), a preference for products that replicate the sensory experience of conventional meat remains dominant. Beyond sensory drivers, meat also carries symbolic meanings associated with tradition, strength and status. These cultural associations reinforce a 'meat-centric’ gastronomic logic, even in vegetarian formats. However, consumer choice can be influenced when a gastronomic authority (i.e. a chef) recommends a less-popular, non-meat-mimicking vegetarian dish. The same cannot be said for social cues (i.e. cues from other guests), which do not appear to influence consumer choice. It is possible that the fragmentary information – whether factual or social – provided to participants within the studies of this dissertation was insufficiently potent to induce continuous and systematic dietary changes in everyday life, suggesting that influence may stem more from particularly influential individuals than from generic others. All in all, this dissertation provides insights into segmentation strategies that may be considered for future product development within the industry, for use within the food-service sector and for methodological application to future research.}, file = {https://oru.diva-portal.org/smash/get/diva2:2002309/FULLTEXT02.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rutegrdmartin_2025_3, title = {SELective defunctioning Stoma Approach in low anterior resection for rectal cancer (SELSA) : Protocol for a prospective study with a nested randomized clinical trial investigating stoma-free survival without major LARS following total mesorectal excision}, author = {Rutegård, Martin and Lindsköld, Marcus and Jörgren, Fredrik and Landerholm, Kalle and Matthiessen, Peter and Forsmo, Håvard Mjørud and Park, Jennifer and Rosenberg, Jacob and Schultz, Johannes and Seeberg, Lars T. and Segelman, Josefin and Buchwald, Pamela}, year = {2025}, journal = {Colorectal Disease}, volume = {27}, number = {2}, doi = {10.1111/codi.70009}, url = {1935156}, language = {eng}, publisher = {Blackwell Publishing}, keywords = {tme; anastomotic leakage; diverting; rectal cancer; stoma}, abstract = {AIM: Accumulated data suggest that routine use of defunctioning stoma in low anterior resection for rectal cancer may cause kidney injury, bowel dysfunction and a higher risk of permanent stomas. We aim to study whether avoidance of a diverting stoma in selected patients is safe and reduces adverse consequences.METHODS: SELSA is a multicentre international prospective observational study nesting an open-label randomized clinical trial. All patients with primary rectal cancer planned for low anterior resection are eligible. Patients operated with curative intent, aged <80 years, with an American Society of Anaesthesiologists' fitness grade I or II, and a low predicted risk of anastomotic leakage are eligible to 1:1 randomization between no defunctioning stoma (experimental arm) or a defunctioning stoma (control arm). The primary outcome is the composite measure of 2-year stoma-free survival without major low anterior resection syndrome (LARS). Secondary outcomes include anastomotic leakage, postoperative mortality, reinterventions, stoma-related complications, quality of life measures, LARS score, and permanent stoma rate. To be able to state superiority of any study arm regarding the main outcome, with 90% statistical power and assuming 25% attrition, we aim to enrol 212 patients. Patient inclusion will commence in the autumn of 2024.CONCLUSION: The SELSA study is investigating a tailored approach to defunctioning stoma use in low anterior resection for rectal cancer in relation to the risk of anastomotic leakage. Our hypothesis is that long-term effects will favour the selective approach, enabling some patients to avoid a defunctioning stoma.TRIAL REGISTRATION: Swedish Ethical Review Authority approval (2023-04347-01, 2024-02418-02 and 2024-03622-02), Regional Ethics Committee Denmark (H-24014463), and ClinicalTrials.gov (NCT06214988).}, issn = {1462-8910} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_pellicomariarosa_2025, title = {Self-efficacy as a key contributor to improved health outcomes in patients with idiopathic inflammatory myopathies}, author = {Pellico, Maria Rosa and Yaadav, Praggya and Russell, Anne-Marie and Lanis, Aviya and Nikiphorou, Elena and Parodis, Ioannis and Sarkar, Manali and Parihar, Jasmine and Andreoli, Laura and Agarwal, Vikas and Gupta, Latika}, year = {2025}, journal = {Rheumatology}, volume = {64}, number = {Suppl. 3}, doi = {10.1093/rheumatology/keaf142.317}, url = {1958701}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background/Aims: Self-efficacy is crucial in chronic disease management, affecting patients’ ability to cope with symptoms and adhere to treatments. Enhancing self-efficacy may reduce morbidity and mortality, lower healthcare costs, and improve quality of life (QoL) for individuals with chronic conditions. This study examined how patients with idiopathic inflammatory myopathies (IIMs) manage work, daily activities, and social interactions amidst their symptoms. We assessed the association between self-efficacy and factors such as education, disease management, QoL, pain, and fatigue, utilizing data from the Collating the Voices of People with Autoimmune Diseases (COVAD)-3 study.Methods: COVAD-3 is a global, cross-sectional survey collecting patient-reported health outcomes using validated instruments. Data extracted in May 2024 included self-efficacy measurements from the Self-Efficacy in Managing Chronic Disease (SEMCD) scale. IIM patients were stratified into high self-efficacy (SEMCD > 6.3) and low self-efficacy (SEMCD < 4.6) groups. Demographic and clinical characteristics were compared using appropriate statistical tests, including chi-square, Mann-Whitney U, and t-tests.Results: Out of 4,052 responses, 314 IIM patients completed the SEMCD (72.6% female; median SEMCD score 5.56). Ninety-five patients were classified as having low self-efficacy, while 110 had high self-efficacy. The high self-efficacy group reported significantly higher life satisfaction scores (p = 0.015), longer disease duration (p = 0.003), lower fatigue levels measured by the Visual Analog Scale (VAS-fatigue, p = 0.009), and better physical function assessed by the PROMIS Physical Function Short Form 4a (p = 0.021). A greater proportion of individuals in this group engaged in regular exercise (p < 0.001). No significant differences were found between the groups regarding education level or trust in healthcare providers. Additionally, self-efficacy levels did not significantly differ across different IIM subtypes.Conclusion: High self-efficacy is associated with better physical and mental health outcomes, increased life satisfaction, and reduced fatigue among IIM patients. These findings highlight the importance of self-efficacy in influencing patient well-being. Healthcare providers should identify factors that affect patients’ self-management abilities and develop strategies to enhance communication and education. By fostering self-efficacy, it may be possible to reduce complications, decrease healthcare costs, and improve health outcomes and QoL. Implementing multidisciplinary approaches, such as patient coaching and support groups, can further empower patients and optimize care delivery.}, issn = {1462-0324} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_yaadavp_2025, title = {SELF-EFFICACY IN IDIOPATHIC INFLAMMATORY MYOPATHIES : A CROSS-SECTIONAL STUDY FROM THE COVAD-3 DATASET}, author = {Yaadav, P. and Pellico, M. R. and Sarkar, M. and Russell, A. M. and Saha, S. and Nikiphorou, E. and Parodis, Ioannis and Lanis, A. and Cheng, K. and Andreoli, L. and Parihar, J. and Agarwal, V. and Gupta, L.}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {84}, number = {Suppl. 1}, doi = {10.1016/j.ard.2025.06.393}, url = {1985773}, language = {eng}, publisher = {Elsevier}, keywords = {quality of life; self-management; outcome measures; patient reported outcome measures; fatigue}, abstract = {Background: Self-efficacy (SE) is fundamental to chronic disease management, emerging as a complex interplay of disease parameters, psychological resilience, social support, comorbidity burden, and financial resources [1]. This demonstrates the need for comprehensive assessment and intervention strategies that address these interconnected domains of wellness. This study investigates SE amongst individuals with idiopathic inflammatory myopathies (IIMs), examining its relationship with disease parameters and health behaviours using data from the Collating the Voice of People in Autoimmune Diseases (COVAD)- 3 study.Objectives: To determine SE levels in IIMs compared with other rheumatic diseases (RMDs) and healthy controls (HC), identify its key predictors, assess associated health outcomes, and evaluate health behaviours linked to higher SE.Methods: We analysed data from the COVAD-3 study cohort, including patient-reported outcomes and the Self-Efficacy in Managing Chronic Disease (SEMCD) scale [2]. Participants were stratified into high (>67th percentile, SEMCD 6.1) and low SE (<33rd percentile, SEMCD 3.6, Figure 1A) groups. Statistical analyses included descriptive statistics, correlation analyses, and multivariate logistic regression to identify SE predictors. Comparative analyses between groups utilised appropriate parametric and non-parametric tests. Based on identified predictors and outcomes, we propose a structured intervention model incorporating peer support, targeted education, and behavioural modification strategies. Thematic analysis was performed to provide qualitative insights into patient experiences and the factors influencing SE (Figure 1B).Results: This analysis of 3,374 participants (439 IIMs, 2,135 RMDs, 800 HCs) from the COVAD-3 registry revealed lower SE scores amongst IIM patients (median SEMCD 5.33) compared to RMDs (5.66) [range 1-10]. IIM patients were characterised by older age at diagnosis, Caucasian predominance, and residence in high HDI regions. They demonstrated shorter disease duration, greater immunosuppressant use, increased autoimmune multimorbidity, and higher functional comorbidity scores compared to RMDs and HCs, while reporting smaller household sizes. Based on SEMCD scores, IIM patients were stratified: 84 showed low SE scores (SEMCD < 3.6) and 164 showed high SE in managing IIMs (SEMCD > 6.1) [Figure 1C, Table 1]. IIM patients with high SE reported significantly better outcomes, including greater satisfaction with life, better physical function (PROMIS Physical SF4a), improved mental health (PROMIS Mental), and better overall physical health (PROMIS Physical). They also had lower fatigue (VAS fatigue), less pain (VAS pain), lower disease activity, and reduced disease damage perception (all p values <.001). Patient trust in health insurance (p = 0.022) and global damage assessment (p = 0.022) were also positively correlated with SE. No significant difference in education level was found with SE in IIMs [Figure 1D]. The logistic regression analysis, adjusted for age, age at diagnosis, gender, and ethnicity identified predictors of high SE using the best-fit model. Factors such as resilience (BRS, OR: 2.582, 95% CI: 0.310–1.588, p = 0.004), regular exercise (OR: 3.563, 95% CI: 0.214–2.327, p = 0.018), and polytherapy (OR: 3.674, 95% CI: 0.184–2.419, p = 0.022) were the positive predictors of high SE. Individuals engaging in regular exercise were more likely to exhibit high SE. Alternatively, the need for increased doses of medication (OR: 0.242, 95% CI: -2.467– -0.369, p = 0.008), and increased levels of loneliness (OR: 0.501, 95% CI: -0.995 – -0.385, p < 0.001) were identified as barriers to high SE, thereby reducing the probability of achieving the confidence in managing IIMs effectively. The predictive model demonstrated robust performance (accuracy 84.2%, sensitivity 91.8%, specificity 70.6%) [Figure 1E]. Thematic analysis identified resilience, exercise, and social support as key enhancers of SE, while loneliness and medication burden emerged as significant barriers in IIM management.Conclusion: Self-efficacy emerges as a crucial determinant of physical and mental well-being in individuals living with IIMs. Our findings illuminate a complex interplay of factors: while resilience, regular exercise, and comprehensive medical management foster confidence in self-management, social isolation and treatment burden pose significant challenges. These insights underscore the importance of holistic care approaches that extend beyond traditional medical management. Tailored interventions integrating physical activity, psychological resilience building, and social support networks could meaningfully enhance self-management capabilities and overall wellness in this challenging chronic condition.}, issn = {0003-4967} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_strmberit_2025, title = {Selfless Servers, Weapons in Waiting : Androids Parenting Human Children in Raised by Wolves and I Am Mother}, author = {Åström, Berit and Bonnevier, Jenny}, year = {2025}, pages = {751--768}, doi = {10.1007/978-3-031-94070-5_40}, url = {2026683}, language = {eng}, publisher = {Palgrave Macmillan}, keywords = {kinship studies; parenthood studies; science fiction; ai; feminist theory; new materialism}, abstract = {This chapter queries how narratives about androids parenting human children can help us understand human parenting practices, their embodied and material character, and our concerns for the future of the children we parent. Their analysis of the two works finds striking differences in how embodied mothering is constructed as well as similarities in the focus on a future, better humanity. The authors conclude that the figure of the android lets us ponder both what we value and what we fear in human parenting practices. In a time when human connection is increasingly mediated by technology, these stories express socio-culturally specific concerns about what is involved in raising children well, highlighting the need for our parenting practices to be guided by the kinds of relations we want our children to be able to form.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nevesguimaraesalessandra_2025, title = {Self-reported data validity for assessment of systemic and oral health as risk for dependency in old age : a cohort profile of elderly individuals in mid Sweden}, author = {Neves Guimaraes, Alessandra and Udumyan, Ruzan and Jayaprakash Demirel, Kartheyaene and Larsson Gran, Pernilla and Starkhammar, Carin and Källestål, Carina}, year = {2025}, journal = {Frontiers in Oral Health}, volume = {6}, doi = {10.3389/froh.2025.1491723}, url = {1946748}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {aging; dependency; general health; longitudinal; selection bias}, abstract = {Purpose: The Mid Sweden Cohort (MSC) was established to investigate self-perceived oral and general health among two groups of aging individuals in two counties (Örebro and Östergötland) in Sweden. For internal and external data validation, we linked collected data on health status, behavior, sociodemographic circumstances, and dependency with national register data from Statistics Sweden and compared non-respondents and those lost to follow-up to respondents.Participants: MSC is based on a longitudinal multiwave study of aging men and women who answered a cross-sectional questionnaire from MSC: (1) the 1992 cohort including participants aged 50 years in 1992 and (2) the 2007 cohort including participants aged 75 years in 2007. After the baseline surveys, data collection was conducted every 5 years, with the latest wave from 2017 included in our validation. Between 1992 and 2017, 8,879 participants were included in cohort 1, while 5,191 individuals were included in cohort 2 between 2007 and 2017.Results: After linking self-reported data with national register-based data and analyzing loss to follow-up and non-response numbers, we found that, besides age, factors such as being male, having immigrant status, lower income and education level, being single, and being in poor health were predictors of non-response and loss to follow-up, aligning with the findings of other studies. Based on our results, we conclude the MSC is reliable for further research, provided the observed bias is taken into account.Future plans: Using the MSC, we aim to analyze self-reported oral health changes as a predictor of dependency in the elderly and track oral health status over time. Furthermore, we plan to link data with register-based clinical oral health records. We also intend to add the 2022 wave data and future waves into the existing dataset.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_shaharirsyahrulsazliyana_2025, title = {Self-Reported Delayed Adverse Events and Flare Following COVID-19 Vaccination Among Patients With Autoimmune Rheumatic Disease (AIRD) in Malaysia : Results From the COVAD-2 Study}, author = {Shaharir, Syahrul Sazliyana and Nawi, Azmawati Mohammed and Mariamutu, Theepa Nesam and Kamaruzaman, Lydia and Said, Mohd Shahrir Mohamed and Rajalingham, Sakthiswary and Parodis, Ioannis and Sarkar, Manali and Shinjo, Samuel Katsuyuki and Kadam, Esha and Ziade, Nelly and Tan, Chou Luan and Gullemin, Francis and Caballero-Uribe, Carlo Vincio and Tan, Ai Lyn and Andreoli, Laura and Parihar, Jasmine and Yaadav, Praggya and Saha, Sreoshy and Gupta, Latika and Agarwal, Vikas}, year = {2025}, journal = {International journal of rheumatic diseases}, volume = {28}, number = {1}, doi = {10.1111/1756-185X.70043}, url = {1926498}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {covid‐19 vaccine; autoimmunity; flares; quality of life}, abstract = {OBJECTIVES: To determine the prevalence of self-reported delayed adverse events (DAEs), major AEs, and flares following COVID-19 vaccinations among patients with autoimmune rheumatic diseases (AIRDs) in Malaysia.METHODOLOGY: An electronically validated survey from the COVID-19 vaccination in autoimmune diseases (COVAD) study group was distributed in July 2021 to patients with autoimmune diseases and healthy controls (HCs). The survey collected data on DAEs (any AE that persisted or occurred after 7 days of vaccination), any early or delayed major adverse events (MAEs), and flares following COVID-19 vaccination. Generalized estimating equation (GEE) models were performed to determine the factors associated with repeated events of DAEs, MAEs, and flares.RESULTS: A total of 556 vaccines were administered to 204 subjects (150 AIRDs and 54 HCs), with 72.1% completing 3 doses. In multivariate GEE analysis, there was a greater frequency of minor DAEs among AIRDs versus HCs (OR 5.65, p = 0.052). The occurrence of MAEs was higher in AIRDs versus HCs (4.9% vs. 1.3%, p = 0.052), but it was no longer significant in the GEE model. In the AIRDs group, the BNT162b2 vaccine increased the risk for minor DAEs (OR4.68, p = 0.02) while patients with autoimmune multimorbidity showed a greater risk for MAEs (OR 8.25, p = 0.007). The rate of flare was 10.6% and multivariate GEE analysis revealed that The rate of flare was 10.6% and multivariate GEE analysis revealed that systemic lupus erythematosus (SLE) (OR0.31, p = 0.03) and hydroxychloroquine (HCQ) (OR 0.16, p < 0.001) were protective against flare.CONCLUSION: The rates of minor DAEs, major AEs, and flares were comparable with other reported studies. Different types of vaccines, underlying AIRDs, and treatments may influence the symptoms of AEs and flares postvaccination against COVID-19.}, issn = {1756-1841} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_deinhardtemmerstefanie_2025, title = {Sepsis in patients who are immunocompromised : diagnostic challenges and future therapies}, author = {Deinhardt-Emmer, Stefanie and Chousterman, Benjamin G. and Schefold, Joerg C. and Flohé, Stefanie B. and Skirecki, Tomasz and Kox, Matthijs and Winkler, Martin S. and Cossarizza, Andrea and Wiersinga, W. Joost and van der Poll, Tom and Weigand, Markus A. and Cajander, Sara and Giamarellos-Bourboulis, Evangelos J. and Lachmann, Gunnar and Girardis, Massimo and Scicluna, Brendon P. and Ferrer, Ricard and Payen, Didier and Weis, Sebastian and Torres, Antoni and Bermejo-Martín, Jesús F. and Osuchowski, Marcin F. and Rubio, Ignacio and Bouma, Hjalmar R.}, year = {2025}, journal = {The Lancet Respiratory Medicine}, volume = {13}, number = {7}, doi = {10.1016/S2213-2600(25)00124-9}, url = {1969959}, language = {eng}, publisher = {Elsevier}, abstract = {Sepsis is a life-threatening, dysregulated host response to infection. Immunosuppression is a risk factor for infections and sepsis. However, the specific immune derangements elevating the risk for infections and sepsis remain unclear in the individual patient, raising the question of whether a general state of immunosuppression exists. In this Review, we explore the relationship between immunosuppression and sepsis, detailing the definitions, causes, and clinical implications. We address the effect of primary immunodeficiencies, acquired conditions, and drugs on the risk of infection and the development of sepsis. Patients with sepsis who are immunocompromised often present with atypical symptoms and diagnostic test results can differ, making early recognition difficult. Future perspectives entail novel biomarkers to improve early sepsis detection and tailored treatments to modulate immune function. Including patients who are immunocompromised in clinical trials is crucial to enhance the relevance of research findings and improve treatment strategies for this vulnerable population.}, issn = {2213-2600} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_germuskovazoja_2025, title = {Septic shock and meningitis caused by Capnocytophaga canimorsus (serovar B) in an immunocompetent patient : case report}, author = {Germuskova, Zoja and Westerholt, Marc and Ocias, Lukas}, year = {2025}, journal = {ASM case reports}, volume = {1}, number = {2}, doi = {10.1128/asmcr.00076-24}, url = {2014480}, language = {eng}, publisher = {American Society for micobiology}, keywords = {capnocytophaga canimorsus; case; immunocompetent; meningitis; serovar}, abstract = {BACKGROUND: Capnocytophaga canimorsus, a Gram-negative rod found in the commensal oral microflora of dogs, is a rare cause of infection following a dog bite, with severe infections more commonly occurring in asplenic or immunocompromised patients. This is a rare case of septic shock and meningitis with a serovar B strain in an immunocompetent patient who passed away due to the infection.CASE SUMMARY: A previously healthy man in his late 50s with no known immunodeficiencies was admitted to the hospital with fever and cognitive deficits after being bitten by a dog. Capnocytophaga canimorsus grew in his cerebrospinal fluid and blood cultures. Despite aggressive fluid therapy, antibiotics, and intensive care, the patient succumbed to the infection. The strain was later characterized as serovar B using whole genome sequencing.CONCLUSION: Even immunocompetent patients are at risk of severe infection caused by Capnocytophaga canimorsus. These infections are an important differential diagnosis in patients presenting with fever following recent dog exposure with serovars A-C being the most common in human clinical isolates.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_mantenoglouperiklis_2025_1, title = {Sequencing in the Run-Time Event Calculus}, author = {Mantenoglou, Periklis and Artikis, Alexander}, year = {2025}, pages = {1607--1614}, doi = {10.3233/FAIA250986}, url = {2023698}, language = {eng}, publisher = {IOS Press}, abstract = {Composite event recognition (CER) systems detect instances of composite activities over streams of timestamped events. A fundamental operator for CER is ‘sequencing’, expressing that two activities take place one after the other. There is no consensus on a universal definition for sequencing. We provide a set of required properties for a sequencing operator for CER, i.e., an interval-based semantics, required for durative activities, and associativity, required to express activity hierarchies. We propose a sequencing operator that satisfies all requirements, as opposed to the ones in the literature, and we implement our operator in the CER engine RTEC. We compare our operator both theoretically and empirically with state-of-the-art approaches, demonstrating its benefits and limitations.}, file = {https://oru.diva-portal.org/smash/get/diva2:2023698/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kochanders_2025, title = {Seroprevalence of seven climate-sensitive zoonoses in Greenland and northern Sweden (1998-2017) : High antibody prevalence against Rickettsia and Leptospira, with Leptospira possibly linked to global warming}, author = {Koch, Anders and Andersen-Ranberg, Emilie and Søborg, Bolette and Evengård, Birgitta and Andersson, Mikael and Ocias, Lukas Frans and Sonne, Christian and Dietz, Rune and Bonefeld-Jørgensen, Eva Cecilie and Søndergaard, Jens and Krogfelt, Karen A. and Jørgensen, Charlotte Sværke}, year = {2025}, journal = {One Health}, volume = {21}, doi = {10.1016/j.onehlt.2025.101244}, url = {2013561}, language = {eng}, publisher = {Elsevier}, keywords = {arctic; borreliosis; brucella; climate changes; climate sensitive infections; coxiella; francisella tularensis; greenland; leptospira; northern scandinavia; rickettsia; seroprevalence; tick-borne encephalitis; zoonoses}, abstract = {BACKGROUND: Climate change may alter zoonotic disease patterns in the Arctic, yet knowledge remains limited.DESIGN: Antibodies to seven zoonotic pathogens were analyzed in 660 unselected human sera drawn from serum banks from Greenland (n = 460) and Northern Sweden (n = 200) (1998-2017), frequency-matched with respect to sex, age, ethnicity and place of living. Greenlandic samples were tested for Francisella tularensis, Brucella melitensis, Brucella abortus, Coxiella burnetii, Rickettsia spp., and Leptospira spp., while Swedish samples also included Borrelia burgdorferi sensu lato (Bbsl) and tick-borne encephalitis virus (TBEV).RESULTS: Leptospira seroprevalence was higher in Greenland 2013 (18 %, 95 % CI 13-24 %) than in Sweden 2012-2017 (4 %, 95 % CI 2-8 %) and increased significantly over time in West Greenland (1998: 2.5 %, 95 % CI 0.8-6 %; 2013: 30 %, 95 % CI 18-45 %, p < 0.001, OR 16.7, 95 % CI 5.7-48.9). Rickettsia seroprevalence remained stable over time (12 %, 95 % CI 5-24 %). Seroprevalence of F. tularensis and B. melitensis/abortus in Greenland 2013 was less than 1 %. In Sweden, seroprevalence was 1 % (95 % CI 0.1-4 %) for B. melitensis/abortus, 2 % (95 % CI 0.1-5 %) for Bbsl, 3 % (95 % CI 1-6 %) for F. tularensis, and 5 % (95 % CI 2-9 %) for TBEV. Antibodies to C. burnetii were not detected in any sample. Two of 81 polar bear samples from East Greenland (2016-2023) were seropositive for Leptospira spp.CONCLUSIONS: This first report on human Leptospira infection in Greenland highlights rising seroprevalence, possibly linked to contaminated water and global warming. Findings emphasize widespread Rickettsia exposure in northern regions and tick-borne pathogens in Sweden, underscoring the need for updated public health data to inform public health planning.}, issn = {2352-7714} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_whitehousedaniel_2025, title = {Serum Biomarkers as Adjuncts to the National Institute for Health and Care Excellence Head Injury Guidelines (NG232, 2023) When Selecting Patients with Traumatic Brain Injury for Computed Tomography : A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Study}, author = {Whitehouse, Daniel and Mikolić, Ana and Czeiter, Endre and Richter, Sophie and Büki, Andras and Wang, Kevin K. and Steyerberg, Ewout and Maas, Andrew and Menon, David and Lecky, Fiona and Newcombe, Virginia}, year = {2025}, journal = {Journal of Neurotrauma}, volume = {42}, number = {17-18}, pages = {1509--1523}, doi = {10.1089/neu.2024.0276}, url = {1957040}, language = {eng}, publisher = {Mary Ann Liebert}, keywords = {biomarkers; brain injuries; emergency medicine; traumatic}, abstract = {This article explores the diagnostic performance of a panel of six biomarkers (glial fibrillary acidic protein [GFAP], neurofilament light [NFL], neuron-specific enolase [NSE], S100 calcium-binding protein B [S100B], total tau [t-tau], and ubiquitin C-terminal hydrolase L1 [UCH-L1]) in the context of the "2023 UK National Institute for Health and Care Excellence (NICE) Head Injury: Assessment and early management (NG232)" guideline. Emphasis is placed on subjects where clinical equipoise remains concerning the decision for head computed tomography (CT), medium-risk subjects. All adult subjects from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) dataset with a complete biomarker profile and interpretable CT scan within 24 h of injury were classified as high, medium, and low-risk according to the NICE NG232 Clinical Decision Rule (CDR) for CT head imaging following head injury. In subjects classified as medium-risk, the area under the receiver operating characteristic curve (AUC) was used to assess the diagnostic performance of biomarkers to identify those with (1) CT abnormality or (2) potential neurosurgical lesion, with CT considered the gold standard diagnosis. A time-to-biomarker sub-analysis was performed in subjects with a time from injury to sampling within 6 h, in keeping with current clinical usage of biomarkers. Among 1979 CENTER-TBI participants with sufficient clinical information to facilitate classification, 385 subjects were classified as medium-risk. Biomarker concentrations were significantly higher in those with traumatic CT abnormalities as compared with those without for all biomarkers aside from NSE (all p < 0.05). When sampled within 24 h of injury, GFAP demonstrated the best diagnostic performance for CT abnormality (AUC 0.81 [0.77-0.86]), with NFL, t-tau, and UCH-L1 showing moderate performance. At a threshold to provide a 95% sensitivity, GFAP, NFL, t-tau, and UCH-L1 demonstrated specificities ranging from 18% to 33% corresponding to a potential reduction of total CT images performed in these subjects by 14-23%. S100B and UCH-L1 showed improved performance when biomarker sampling time was limited to 6 h following injury. In intoxicated subjects with a persistent Glasgow Coma Score of 13-14, biomarker levels were significantly higher in subjects with CT abnormality as compared with those without. In conclusion, serum biomarkers demonstrate potential for the reduction in CT scan requirements in those classified as medium-risk in reference to the NG232 CDR criteria. These results highlight a need for further prospective studies on the use of diagnostic TBI biomarkers in current emergency medicine practice, with future consideration given to the integration of biomarkers in the NICE NG232 head injury guidelines.}, issn = {0897-7151} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_anderssonaxelg_2025, title = {Serum, urinary and fecal concentrations of perfluoroalkyl substances after interventions with cholestyramine/colesevelam and probenecid : cross-over trials in Ronneby, Sweden}, author = {Andersson, Axel G. and Xu, Yiyi and Kärrman, Anna and Cederlund, Julia and Lindh, Christian H. and Pineda, Daniela and Fletcher, Tony and Jakobsson, Kristina and Li, Ying}, year = {2025}, journal = {Environment International}, volume = {204}, doi = {10.1016/j.envint.2025.109794}, url = {1999623}, language = {eng}, publisher = {Elsevier}, keywords = {bile acid sequestrant; clinical trial; cross-over; pfas; probenecid}, abstract = {BACKGROUND: Some per- and polyfluoroalkyl substances (PFAS) such as perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) are very long-lived in humans, with serum half-lives of several years. In PFAS hot spots, such as Ronneby, Sweden, high exposures over time have led to markedly elevated serum PFAS levels, which may result in health risks as well as transfer to the next generation through pregnancy and breastfeeding. Bile acid sequestrants and organic anion transporter inhibitors are drug candidates for increasing PFAS elimination in humans.MATERIALS AND METHODS: This is a cross-over, clinical study in 10 individuals from Ronneby, Sweden. First, participants were given the bile acid sequestrant cholestyramine and the organic anion transporter inhibitor probenecid for 1 week each. Urinary and fecal concentrations were measured prior, during and after the administration. Then, the changes of serum PFAS concentrations during a 12-week intervention with the bile acid sequestrant colesevelam were compared to a control period.RESULTS: The study population was mainly exposed to PFHxS (serum mean 50 ng/mL, range 5.8-170), PFOS (serum mean 46 ng/mL, range 9.2-130) and PFOA (serum mean 2.2, range 0.7-4.4). Cholestyramine intervention increased the serum adjusted fecal PFOS concentrations by 23.1 times (95 %CI: 13.6, 39.2), while probenecid was associated with 0.79 times (95 %CI 0.63, 1.0) serum-adjusted urinary PFOS concentrations, compared to no intervention. The 12-week intervention with colesevelam resulted in a mean serum PFOS decline of 38 % (95 %CI -42, -34), compared to 2 % (95 %CI -8, 5) in the control period. The decline was smaller for PFHxS and PFOA.CONCLUSIONS: Bile acid sequestrants could be used for accelerating PFAS excretion in highly PFAS exposed individuals. Studies are needed to evaluate the risks, costs and benefits of using it for this purpose.}, issn = {0160-4120} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hanssonmats_2025, title = {Setting up mother-infant pair lactation studies with biobanking for research according to regulatory requirements}, author = {Hansson, Mats and Björkgren, Ida and Svedenkrans, Jenny and Backman, Helena and Hellman, Jarl and Englund-Ögge, Linda and Magnusson, Mikaela and Lindström, Inger and Wutte, Andrea and Sundell, Erica and Baranczewski, Pawel and Shaughnessy, Laura}, year = {2025}, journal = {British Journal of Clinical Pharmacology}, doi = {10.1002/bcp.70201}, url = {1991175}, language = {eng}, publisher = {Wiley-Blackwell}, keywords = {drug safety; medication safety; patient safety}, abstract = {Within the ConcePTION project we set out to design two mother-infant pair studies collecting breast milk and plasma from the mother and plasma from the infant (for metformin and prednisolone) in order to demonstrate the premises and conditions for investigating potential drug transfer in association with breastfeeding. It is essential that the information from lactation studies is trustworthy and fulfils regulatory standards and requirements for the results to be fit for label. In this paper we describe the premises and conditions for mother-infant pair studies and biobanking for research of collected samples as laid down in regulatory requirements. The studies on metformin are still ongoing. At the time of the study (June 2025), 18 participants had been included in the metformin study and 20 in the prednisolone study. Evidence for the use of medicines in association with breastfeeding is urgently needed, both for already approved and used drugs, and for the development of new drugs. Based on our experiences within the IMI-ConcePTION project, we have described the premises for mother-infant pair studies to be adhered to.}, issn = {0306-5251} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_qandeelmais_2025_5, title = {Settler Violence as State Wrongful Act and Third State Obligations}, author = {Qandeel, Mais}, year = {2025}, journal = {Opinio Juris (blog)}, url = {1993420}, language = {eng}, publisher = {Opinio Juris}, abstract = {This post provides a brief legal assessment – within the provisions of the law of occupation – on Third States obligations to take measures against Israeli settler violence. In this post, I build on the study Violence and State Attribution: The Case of Occupied Palestine and the ICJ’s Advisory Opinion of July 2024 on Legal Consequences arising from the Policies and Practices of Israel in the Occupied Palestinian Territory, including East Jerusalem. I briefly discuss the legal basis on which Third States must prevent, stop and punish settler violence as a form of State atrocities. I argue that these sanctions imposed by a few countries are insufficient and misplaced. Additionally, they are redirecting State attributed internationally wrongful acts to a handful of individuals – designated as terrorists – while allowing the State itself to carry on and allowing such acts. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_martinimiriami_2025, title = {Sex differences in psychiatric diagnoses preceding autism diagnosis and their stability post autism diagnosis}, author = {Martini, Miriam I. and Kuja-Halkola, Ralf and Butwicka, Agnieszka and Du Rietz, Ebba and Kanina, Aleksandra and Brikell, Isabell and Chang, Zheng and Larsson, Henrik and Lichtenstein, Paul and Bölte, Sven and Happé, Francesca and Taylor, Mark J.}, year = {2025}, journal = {Journal of Child Psychology and Psychiatry}, volume = {66}, number = {8}, pages = {1170--1181}, doi = {10.1111/jcpp.14130}, url = {1941693}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {autism spectrum disorder; follow‐up study; psychiatric diagnoses; sex differences}, abstract = {BACKGROUND: Autistic individuals often receive psychiatric diagnoses prior to their autism diagnosis. It remains unclear to what extent autistic females and males differ in their likelihood of receiving psychiatric diagnoses prior to their autism diagnosis and continue seeking care for them after an autism diagnosis.METHODS: In a nationwide cohort of all individuals born in Sweden 1990-2015 with a clinical autism diagnosis (N = 72,331, nfemales = 24,110), we used linear and logistic regression to estimate the association between sex and (a) psychiatric diagnoses before autism diagnosis, including time trends by autism diagnosis year (2010-2020), (b) autism diagnosis age in those with preceding diagnoses, (c) stability of preceding diagnoses (defined as continued care utilization indicated through diagnosis or medication in the 5 years following autism diagnosis).RESULTS: In total 54.2% of autistic females and 40.9% of autistic males received at least one preceding psychiatric diagnosis (most common: ADHD, anxiety, depression). Autistic females showed higher odds than males for most preceding psychiatric diagnoses (ORrange = 1.29 [1.18, 1.41]-10.69 [8.06, 14.17]), except psychotic disorders (OR = 0.91 [0.78, 1.06]) and ADHD (OR = 0.69 [0.66, 0.71]). Sex differences in preceding diagnoses were persistent across different autism diagnosis years (2010-2020). For most conditions, females with a preceding diagnosis were diagnosed with autism later than males with the same condition. For both sexes, the stability of preceding diagnoses varied considerably (23.1%-88.9%) and was less than 50% for most diagnoses. Females showed a higher stability for anxiety, sleep disorders and self-harm (ORrange = 1.45 [1.30, 1.62]-2.37 [1.93, 2.90]), and males for psychotic disorders (OR = 0.60 [0.44, 0.81]).CONCLUSIONS: Autistic females are more likely to be diagnosed with psychiatric conditions prior to an autism diagnosis and receive care for them post autism diagnosis. Our findings emphasize the variability of clinical presentation and importance of disentangling persistent support needs from overlapping diagnostic presentations, particularly in autistic females, to provide appropriate and timely care.}, issn = {0021-9630} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_smithkelsi_2025, title = {Sex differences in the association of the melanocortin-1 receptor (MC1R) gene with multiple sclerosis risk}, author = {Smith, Kelsi and Shchetynsky, Klementy and Hedström, Anna Karin and Huang, Jesse and Kockum, Ingrid and Hillert, Jan and Olsson, Tomas and Alfredsson, Lars and Montgomery, Scott and Stridh, Pernilla}, year = {2025}, journal = {Multiple Sclerosis Journal}, volume = {31}, number = {Suppl. 3}, pages = {547--548}, url = {2038407}, language = {eng}, publisher = {Sage Publications}, abstract = {Introduction: Sunlight, vitamin-D, and sex are associated with MS risk. The melanocortin-1 receptor (MC1R) pigmentation gene may be involved in pathways between sunlight exposure, vitamin-D and MS risk, as red-hair colour (RHC) associated variants have been implicated in MS risk and the association may vary by sex. Tubulin beta 3 class III (TUBB3) overlaps the MC1R region and is involved in axonal and dendritic growth in the CNS.Objectives/Aims: Determine if MC1R/TUBB3 variants are independently associated with MS risk.Methods: Data includes genotypes, clinical and demographic information from Swedish national registers, and self-reported lifestyle and environmental factors from 6585 MS cases and 5881 controls. MC1R genotypes including the shared region (TUBB3) where RHC associated variants are located were extracted. Analyses were sex-stratified and mixed-linear models adjusted for genetic relatedness (MLMA-GREML) and used to assess associations between MC1R-TUBB3 and MS risk. SNP independence was evaluated using logistic regression models including significant variants and known MS risk factors.Results: Of 5 available RHC SNPs, rs885479 was statistically significantly associated with MS risk, and remained significant after correcting for multiple testing (n=5, p=0.01). An inverse association with MS was observed for rs885479 only among females [beta= -0.045, SE 0.015, p<0.01: odds ratio (OR) 0.83], with a 17% reduction in MS risk among female carriers. No association was observed among males. No other variants in the extended MC1R-TUBB3 locus were associated with MS. The association with rs885479 (within the MC1R-TUBB3 shared region) among females was independent of known MS risk factors such as vitamin-D genetic risk score, smoking prior to MS onset/matching, BMI in adolescence, or adjustment for key genetic risk factors for MS including HLA DRB1*15:01 and HLA-A*02:01 [OR 0.77, CI 0.77-0.89]. An additive effect of rs885479 was observed [homozygotes OR 0.50, CI 0.27-0.95; heterozygotes OR 0.85, CI 0.74-0.97] that remained after adjustment for the same factors as previously listed and became larger in magnitude [homozygotes OR 0.29, CI 0.13-0.61; heterozygotes OR 0.80, CI 0.0.69-0.93].Conclusion: RHC variant rs885479 in MC1R is associated with the risk of developing MS, and appears to be independently associated with MS irrespective of other MS risk factors. The association was only notably observed in females, and may represent a female-specific MS risk SNP.}, issn = {1352-4585} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hoffartamundrake_2025, title = {"Sex" og "gender" i skandinaviske fortolkninger og oversettelser av Judith Butlers filosofi}, author = {Hoffart, Amund Rake}, year = {2025}, journal = {Agora Journal for metafysisk spekulasjon}, volume = {43}, number = {1-2}, pages = {39--65}, url = {1976453}, language = {nor}, publisher = {Aschehoug & Co}, issn = {0800-7136} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_solmimarco_2025, title = {Sex-stratified mortality estimates in people with schizophrenia : A systematic review and meta-analysis of cohort studies of 2,700,825 people with schizophrenia}, author = {Solmi, Marco and Croatto, Giovanni and Fabiano, Nicholas and Wong, Stanley and Gupta, Arnav and Fornaro, Michele and Schneider, Lynne Kolton and Rohani-Montez, S. Christy and Fairley, Leanne and Smith, Nathalie and Bitter, István and Gorwood, Philip and Taipale, Heidi and Tiihonen, Jari and Cortese, Samuele and Dragioti, Elena and Rietz, Ebba Du and Nielsen, Rene Ernst and Firth, Joseph and Fusar-Poli, Paolo and Hartman, Catharina and Holt, Richard I. G. and Høye, Anne and Koyanagi, Ai and Larsson, Henrik and Lehto, Kelli and Lindgren, Peter and Manchia, Mirko and Nordentoft, Merete and Skonieczna-Żydecka, Karolina and Stubbs, Brendon and Vancampfort, Davy and Vieta, Eduard and De Prisco, Michele and Boyer, Laurent and Højlund, Mikkel and Correll, Christoph U.}, year = {2025}, journal = {European Neuropsychopharmacology}, volume = {91}, pages = {56--66}, doi = {10.1016/j.euroneuro.2024.11.001}, url = {1920320}, language = {eng}, publisher = {Elsevier}, keywords = {antipsychotic; meta-analysis; mortality; schizophrenia; sex; systematic review}, abstract = {The differential influence of sex on premature mortality in schizophrenia is unclear. This study assessed the differences in all-cause and specific cause mortality risks in people with schizophrenia compared to several control groups stratified by sex. We conducted a PRISMA 2020-compliant systematic review and random-effects meta-analysis of cohort studies assessing mortality relative risk (RR) for people with schizophrenia, comparing by sex. We measured publication bias and conducted a quality assessment through the Newcastle-Ottawa scale. We meta-analyzed 43 studies reporting on 2,700,825 people with schizophrenia. Both males and females with schizophrenia had increased all-cause mortality vs. comparison groups (males, RR=2.62, 95%CI 2.35-2.92; females, RR=2.56, 95%CI 2.27-2.87), suicide (males, RR=9.02, 95%CI 5.96-13.67; females, RR=12.09, 95%CI 9.00-16.25), and natural cause mortality (males, RR=2.11, 95%CI 1.88-2.38; females, RR=2.14, 95%CI 1.93-2.38). No statistically significant differences in sex-dependent mortality risk emerged. There was an age-group-dependent increased mortality risk in females < 40 years vs. >/=40 years old (RR=4.23/2.17), and significantly higher risk of death due to neurological disorders (dementia) in males vs. females (RR=5.19/2.40). Increased mortality risks were often associated with specific modifiable risk factors. The increased mortality risk did not improve over time, calling for more studies to identify modifiable factors, and for better physical healthcare for males and females with schizophrenia.}, issn = {0924-977X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jonssonsofia_2025, title = {Sexual Corruption and Political (Dis)trust}, author = {Jonsson, Sofia}, year = {2025}, journal = {Political Studies}, doi = {10.1177/00323217251335758}, url = {1961510}, language = {eng}, publisher = {Sage Publications}, keywords = {sexual corruption; political trust; gender; democracy; victimization}, abstract = {The debate about how corruption is linked to political trust is ongoing. The recent conceptualization of sexual corruption calls for the exploration of how gendered experiences of corruption affect trust levels. This study proposes that the sex in sexual corruption, compared to monetary bribes, changes the dynamics of the relationship between service-seeker and provider. The lock-in effects and feelings of betrayal break political trust in a more pronounced way than conventional corruption does. The cross-sectional analyses of individuals in 27 European countries show that both women and men exposed to sexual corruption have less trust in their government compared to non-victims and compared to service-seekers in conventional corruption. These findings enhance our understanding of the corruption-trust nexus and suggest that the magnitude of sexual corruption cases hitherto overlooked, more than causing individual suffering, might have far-reaching and negative consequences for the quality of democracy.}, issn = {0032-3217} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jafdarun_2025, title = {Sexual revictimization by peers in school and organized activity contexts among adolescents : A 3-year longitudinal study}, author = {Jaf, Darun and Holmqvist Gattario, Kristina and Geidne, Susanna and Lunde, Carolina and Skoog, Therése}, year = {2025}, journal = {Developmental Psychology}, volume = {61}, number = {4}, pages = {795--810}, doi = {10.1037/dev0001744}, url = {1883110}, language = {eng}, publisher = {American Psychological Association (APA)}, keywords = {sexual harassment revictimization; depressive symptoms; subjective well-being; school context; organized activity contexts}, abstract = {Based on sexual revictimization theory, this study investigates the role of individual characteristics (e.g., depression and subjective well-being) and contextual factors (school and organized activities) in the development of sexual harassment revictimization among Swedish Grade 7 (46% girls; Mage = 14.09) adolescents who were followed over 3 consecutive years. The analytic sample comprises adolescents in the school context (T1 N = 678, T2 N = 563, and T3 N = 471) and in organized free-time activity contexts (T1 n = 443, T2 n = 400, and T3 n = 356). Our findings suggest that adolescents with experiences of sexual harassment victimization in Grade 7 were at an increased risk of being sexually revictimized the following 2 years across the two distinct developmental contexts. Further, our results reveal that adolescents are more sexually harassed by their peers in organized activity contexts both concurrently and over time if they were victims of sexual harassment in the school context and the other way around. The findings underscore the need for sexual harassment prevention interventions to consider different developmental contexts simultaneously and to focus on the history of adolescents' experiences of victimization.}, issn = {0012-1649} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_leklara_2025, title = {Sexuality in Residential Aged Care : The Resident´s Perspective}, author = {Le, Klara and Bennich, Maria and Strandberg, Thomas}, year = {2025}, journal = {Journal of gerontological social work}, volume = {68}, number = {8}, pages = {1182--1203}, doi = {10.1080/01634372.2025.2517308}, url = {1966962}, language = {eng}, publisher = {Routledge}, keywords = {sexuality; older adults; residential aged care; sexual script; qualitative study}, abstract = {This study investigates how older adults in Residential Aged Care (RAC) perceive and navigate their sexuality. Employing a qualitative approach with semi-structured interviews, it examines older adults’ perceptions of sexuality while living in RAC, the barriers they encounter, and the ways they maintain or adapt their sexuality. Data were collected from 15 participants in Swedish RAC facilities. Nine identified as women and six as men, with a mean age of 87.3. The analysis identified three principal themes: The Sexual Script for Older Adults, Co-creating the Script, and Navigating the Script. These themes highlight how older adults articulate their sexuality, respond to institutional norms, and sometimes resist expectations. The findings suggest that sexuality remains a substantial aspect of life for many older adults, even when they face age-related stigma or institutional limitations. This study underscores the need for RAC to better support the sexuality of older adults and advocates for policies that recognize and facilitate their sexual autonomy and well-being.}, issn = {0163-4372} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrkvallanders_2025_5, title = {Shaping and Writing by Hand : On Situated Uses and Semiotic Potentials of Digital Pencils in a Swedish Fourth-Grade Class}, author = {Björkvall, Anders and Lindstrand, Fredrik and Melander, Ida}, year = {2025}, pages = {25--44}, doi = {10.5040/9781350405110.0009}, url = {1941053}, language = {eng}, publisher = {Bloomsbury Academic}, keywords = {affrodance; multimodal ethnography; digital pencil; recontextualization; indexicality; social semiotics; designs for learning} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_patelankitr_2025, title = {Shaping In-Vehicle Behaviours through Activity-Centered Design}, author = {Patel, Ankit R. and Gershon, Pnina and Habibovic, Azra and Novakazi, Fjollë and Akahoshi, Sakura and Alsaid, Areen and Cha, Kyungjoo}, year = {2025}, pages = {302--305}, doi = {10.1145/3744335.3749141}, url = {2038996}, language = {eng}, publisher = {Association for Computing Machinery (ACM)}, keywords = {activity-centered design; in-vehicle technology; personalization; user-centered design; users' experience}, abstract = {In today's fast-paced society, most individuals commute either by personal vehicle or public transportation. User preferences and requirements are crucial, with design playing a significant role. The nature of design should be such that it is both inclusive and assimilative, and its purpose is to propel innovation and progress while also improving the quality of life of the user. That is why a general focus was given to the user-centered design approach while developing vehicles, especially, cabin (cockpit) design. With prioritizing the user activities, it is interesting to explore how users' experience and behavior vary through the application of different design approaches. Nevertheless, existing literature has significantly overlooked the impact of design approaches on "human activity". Therefore, the main objective of the workshop is to examine the relationships between activity-centered design and user behavior.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_loidpetra_2025, title = {Short stature, brachydactyly and joint contractures associated with novel FBN2 variants in two families}, author = {Loid, Petra and Wang, Fan and Lennartsson, Otto and Muurinen, Mari and Costantini, Alice and Vats, Sakshi and Lodefalk, Maria and Nilsson, Ola and Mäkitie, Outi}, year = {2025}, journal = {Journal of Medical Genetics}, volume = {62}, number = {7}, pages = {436--440}, doi = {10.1136/jmg-2024-110533}, url = {1951297}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {endocrinology; genetic testing; human genetics}, abstract = {BACKGROUND: Fibrillinopathies comprise allelic disorders with opposing phenotypes. Pathogenic variants in fibrillin-2, encoded by FBN2, have mainly been associated with congenital contractural arachnodactyly but in a few cases also with brachydactyly.METHODS AND RESULTS: We recruited two families with index patients presenting with short stature (heights ≤3 SD scores), brachydactyly, joint contractures and facial dysmorphism as major features. In Family 2, the proband and father also had carpal tunnel syndrome. Radiographs showed signs of mild skeletal dysplasia with short long bones, brachydactyly and mild metaphyseal and vertebral irregularity. Whole genome sequencing revealed novel variants in the FBN2 gene that segregated with the phenotype: in Family 1, a novel heterozygous missense variant c.4862G>A, p.(Cys1621Tyr) and in Family 2, a novel heterozygous deletion of exons 9-11. The missense variant affects a highly conserved residue and is predicted to be deleterious by most in silico tools. The FBN2 deletion affects a well-conserved region and leads to loss of the transforming growth factor β binding-like 2 domain and part of the calcium-binding epidermal growth factor-like domain.CONCLUSION: Our findings suggest that short stature and mild skeletal dysplasia might be part of the spectrum of FBN2-related phenotypes. The study supports the role of FBN2 variants in growth failure and expands the molecular spectrum of FBN2 variants.}, issn = {0022-2593} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sandstrmloisa_2025, title = {Short-term impact of preschool sound exposure on outer hair cell function in young children : An analysis using pressurised distortion product otoacoustic emissions}, author = {Sandström, Loisa and Fredriksson, Sofie and Mäki-Torkko, Elina and Ögren, Mikael and Fels, Janina and Waye, Kerstin Persson}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {11}, doi = {10.1371/journal.pone.0332863}, url = {2016183}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {BACKGROUND: Preschool children are regularly exposed to high noise levels that may affect hearing. A previous study has linked preschool noise exposure to reduced distortion product otoacoustic emission (DPOAE) amplitudes. Since DPOAEs primarily reflect outer hair cell (OHC) activity, they provide an indirect marker of cochlear function. Measurement accuracy can be affected by middle-ear pressure. Pressurised DPOAEs (pDPOAEs) compensate for middle-ear pressure during recording.METHODS: This cross-sectional study aimed to examine the relationship between preschool noise exposure and pDPOAE amplitudes while accounting for middle-ear pressure. Seventy-five children (4-6 years old) were monitored using dosimeters to measure the equivalent continuous sound level (LAeqTi) and the 95th percentile of maximum levels (LAFmax,95). Of these, 56 children completed pDPOAE testing at four time points during the preschool week. Linear mixed-effects models evaluated associations with noise exposure, time of day and progression across the week.RESULTS: For personal dosimetry, the mean LAeqTi was 80 dB (range: 60-98 dB) and the mean LAFmax,95 was 97 dB (range: 77-110 dB). Most LAeqTi levels (86.2%) were between 75-85 dB, with LAFmax levels exceeding 115 dB in 53.8% of the cases. No significant associations were found between LAeqTi or LAFmax,95 and pDPOAE amplitudes (p > 0.05). Time-of-day differences were observed, with higher amplitudes in the afternoon at 4 kHz (p = 0.045) and 6 kHz (p = 0.047) in the right ear, and 3 kHz in the left ear (p = 0.021). Girls showed higher amplitudes than boys at 4 kHz in the left ear (p = 0.030).CONCLUSIONS: Although pDPOAE amplitudes varied with time of day, and sex, a direct exposure-response relationship with preschool noise was not demonstrated. Short-term variations in typical preschool noise exposure may not measurably affect cochlear function in young children. Future research should refine exposure assessment and recording protocols to reduce variability and improve detection of small physiological changes.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rydbeckdaniel_2025, title = {Short-term outcomes from the 'Watch and Wait' (WoW) study : prospective cohort study}, author = {Rydbeck, Daniel and Azhar, Najia and Blomqvist, Lennart and Chabok, Abbas and Folkesson, Joakim and Gerdin, Anders and Hermus, Linda and Matthiessen, Peter and Martling, Anna and Nilsson, Per J. and Angenete, Eva}, year = {2025}, journal = {BJS Open}, volume = {9}, number = {1}, doi = {10.1093/bjsopen/zrae151}, url = {1931324}, language = {eng}, publisher = {Oxford University Press}, keywords = {informed consent; biopsy; follow-up neoadjuvant therapy; prospective studies; safety; surgical procedures; operative abdomen guidelines neoplasms surgery specialty rectal carcinoma metastasis; distant; cardiocerebral resuscitation; complete remission; primary outcome measure}, abstract = {BACKGROUND: Despite absence of level 1 evidence on the long-term oncological safety of non-operative management for rectal cancer (watch and wait), increased implementation has occurred globally over the past decades. In Sweden, a pan-national prospective non-randomized study was initiated in 2017 to assess its implementation.METHOD: Patients with biopsy-proven rectal cancer receiving neoadjuvant therapy according to national guidelines in whom a clinical complete response was detected at reassessment were eligible for inclusion following informed consent. Only patients with an opportunistic watch-and-wait approach were included. Inclusion and follow-up, according to the study protocol, was managed at the participating study centres. The primary outcome measure of the study is 3-year disease-free survival. Here, the secondary short-term outcomes local regrowth rate, distant metastasis rate and outcomes after surgery for regrowth, at 6 months follow-up, are reported.RESULTS: Between January 2017 and February 2023, 211 patients with a clinical complete response were included in the study. Thirty-three (16%) patients developed suspicious regrowth within 6 months of inclusion. Thirty-two of 33 patients had abdominal resectional surgery for regrowth. The curative intention rate was 94% for patients with regrowth. Three patients (1.4%) developed distant metastases within 6 months of inclusion.CONCLUSION: This Swedish national study on watch and wait reports regrowth rates after 6 months are in line with previous reports in the literature. Nearly all patients with early regrowth could be treated with salvage surgery and curative intent.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bennichmaria_2025, title = {Should social workers (learn to) care? How educational reforms affect the social work profession}, author = {Bennich, Maria and Brauer, John}, year = {2025}, journal = {Nordic Social Work Research}, pages = {1--14}, doi = {10.1080/2156857x.2025.2497925}, url = {1958362}, language = {eng}, publisher = {Routledge}, keywords = {jurisdiction; social care; educational reform}, abstract = {The professional jurisdiction of social workers is subject to continuous change. Such changes are often assumed to be based on actions taken by the profession; an assumption that downplays the influence of external factors. This paper investigates the influence of educational reforms on jurisdictional change by examining the addition of social care to the professional jurisdiction of social workers. The paper is based on an analysis of public reports and the curricula of all social work programmes in Sweden. The findings show that only one curriculum has mandatory courses in social care, while most other curricula have non-mandatory courses on ageing. The findings support the hypothesis that educational reforms can drive changes in professional jurisdiction. However, the path-dependent nature of higher education institutions may lead to gaps between the intention and embodiment of such reforms, which is shown in the empirical analysis. Finally, there are tensions between the idea of a generalist social work programme and ensuring that newly qualified social workers are prepared to work in the specialized sectors of social work.}, issn = {2156-857X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_baptistaiuri_2025_1, title = {Should we offer oat drink? Exploring availability and positioning as strategies to reduce milk consumption at a self-service lunch restaurant}, author = {Baptista, Iuri and Neuman, Nicklas and Zorell, Carolin and Öström, Åsa}, year = {2025}, journal = {International Journal of Gastronomy and Food Science}, volume = {42}, doi = {10.1016/j.ijgfs.2025.101333}, url = {2014189}, language = {eng}, publisher = {Elsevier}, keywords = {consumer science; food service; sustainability; field study; plant-based}, abstract = {Dairy products are the second greatest contributor to the environmental burden of food in Europe, surpassed only by meat. The objective of this field study was to explore availability and positioning as strategies to promote the substitution of milk for a plant-based alternative on the coffee counter of a weekday self-service restaurant. Data on consumption of milk and oat drink of 6147 meals were collected in four different conditions: only milk (control), only oat drink, both beverages on both sides, both beverages on different sides of the coffee counter. Results show a 38 % decrease in milk consumption per paying customer on days when both beverages were available compared to control, leading to an estimated 32 % decrease in greenhouse gas emissions (GHGE). Contrary to hypothesized, the total volume of beverages was 12 % lower on days when both milk and oat drink were served compared to control days, causing a 9 % decrease in total costs. The ratio of milk by oat drink was also 21 % lower when each beverage was served on different sides of the counter compared to when both were served on both sides. Our study suggests that serving a plant-based alternative and creating small barriers to milk are promising strategies to reduce GHGE in day-to-day gastronomic venues.}, issn = {1878-450X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wettermarkanna_2025, title = {Silent entrepreneuring : complying with and refusing entrepreneurial norms through practices of tactical subordination and shielding space}, author = {Wettermark, Anna and Berglund, Karin}, year = {2025}, journal = {Human Relations}, volume = {78}, number = {6}, pages = {791--819}, doi = {10.1177/00187267251318960}, url = {1941201}, language = {eng}, publisher = {Sage Publications}, keywords = {entrepreneuring; gender; organizational norms; practices; refusal; silence}, abstract = {Entrepreneurship is often understood as acting boldly on the market, broadcasting one’s endeavours in persuasive success stories. We, in contrast, seek to understand less flamboyant entrepreneurial practices by examining the creativity and innovations pursued by a gendered and marginalized professional group in the public sector. Through an ethnographic study of hospital pharmacists during the COVID-19 pandemic, we seek to understand how pharmacists ‘do’ entrepreneuring at work, what practices they engage in, and how they act creatively, sometimes breaking with role expectations, and seldom receiving recognition for what they are doing. In the article, we refer to this as silent entrepreneuring – a form of entrepreneuring that simultaneously complies with and refuses entrepreneurial ideals. By adopting two contrasting but complementary analytical positions, we examine the often unspoken activities of pharmacists and how they form practices that both support and contradict each other. We conclude by suggesting that the concept of silent entrepreneuring enables a broadened understandi of organizational entrepreneurship that calls for greater sensitivity towards the different forms that entrepreneuring may take.}, issn = {0018-7267} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrklundfilip_2025_2, title = {Similar risk of hospitalization and mortality for patients continuing and discontinuing LTOT}, author = {Björklund, Filip and Palm, Andreas and Sundh, Josefin and Khor, Yet H. and Ekström, Magnus}, year = {2025}, journal = {Respiratory Research}, volume = {26}, number = {1}, doi = {10.1186/s12931-025-03417-0}, url = {2014083}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {ltot; mortality}, abstract = {INTRODUCTION: While the characteristics and medical management of patients treated with long-term oxygen therapy (LTOT) have transformed during the last decades, the evidence base for LTOT itself remains largely unchanged. This study aimed to compare the risk of hospitalization and death among hypoxemic patients discontinuing LTOT, with that of controls continuing therapy.METHODS: This was a retrospective observational study of patients with LTOT included in the DISCOVERY cohort, using elements of target trial emulation. Patients who fulfilled LTOT criteria but discontinued treatment with LTOT within 90 days of initiation, not due to improving oxygenation or change of treatment modality, were identified. The risk of hospitalization and death as a composite outcome, and the risks of individual outcomes of hospitalization and death, were compared with age-, sex- and disease type-matched controls who continued LTOT, using Cox regression adjusted for confounders.RESULTS: In total, 79 patients discontinuing LTOT and 395 controls were analyzed, both groups with a mean age of 73 (SD ± 11) years, 72% females, 65% underlying COPD. In adjusted Cox regression models, discontinuing LTOT was not associated with an increased risk of hospitalization or death (hazard ratio (HR) 1.0 95% Confidence interval (CI) 0.78-1.3), hospitalization (HR 0.99 95% CI 0.75-1.3), or death (HR 0.79 95% CI 0.61-1.0).CONCLUSION: In this study, patients fulfilling LTOT initiation criteria who discontinued therapy were not found to be at an increased risk of hospitalization or death, suggesting equipoise for a randomized trial of LTOT discontinuation or non-initiation in selected patient groups.}, issn = {1465-9921} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sjbergcarina_2025_1, title = {Simulation-based learning in postgraduate critical care and anaesthesia nursing : an interview study from postgraduate nurses' perspectives}, author = {Sjöberg, Carina and Jildenstål, Pether and Ringdal, Mona and Amorøe, Torben Nordahl and Sjöstedt, Viktoria and Cederwall, Carl-Johan}, year = {2025}, journal = {BMC Nursing}, volume = {24}, number = {1}, doi = {10.1186/s12912-025-03336-x}, url = {1981409}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {postgraduate critical care and anaesthesia nursing; simulation-based learning}, abstract = {BACKGROUND: Simulation-based learning is used to educate students in anaesthetics and critical care. At the postgraduate level, the aim is to foster an understanding of the connection between theory and practice and prepare nurses for the clinical environment. In this context, we created a new wherein we integrated simulation-based learning with clinical learning activities e.g. before start of clinical practice, during and after end of clinical practice. The postgraduate nurses were educated and instructed by university teachers from the postgraduate program and clinical active tutors, critical care nurses and registered nurse anaesthetists from the simulation center. This study aimed to explore the experiences of postgraduate nurses with simulation-based learning and its impact on their overall learning outcomes.METHOD: This is a descriptive qualitative interview study with a purposeful sample of postgraduate nurses with experience with simulation-based learning during clinical practice. The data were analysed using inductive and thematic analysis.RESULTS: We identified two themes 'pros of simulation-based learning' and 'cons of simulation- based learning' describing opportunities and obstacles related to the postgraduate nurses' experience of simulation-based learning. 'Pros of simulation-based learning' included the subthemes 'learning through scenarios facilitates preparedness for clinical practice,' 'learning via reflection gives you time to think over your actions' and 'Learning from tutors is valuable and highly regarded 'Cons of simulation based learning' included the subthemes 'it is difficult to accept the simulation situation and environment, 'the design of the scenarios and technical conditions constitutes a barrier' and 'Unfamiliar groups interfere with learning.CONCLUSION: This study shows that simulation-based learning activities promoted postgraduate nurses learning especially later in the education. Competence required for critical care nurses and registered nurse anesthetists is situational and competence specific, theoretical background and clinical experience are therefore required to promote progression in learning.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ochiyotaro_2025, title = {Single-cell multi-omics uncovers differentiation-dependent transcriptional programs shaping epigenetic subgroups in AML}, author = {Ochi, Yotaro and Liew-Littorin, Markus and Ogawa, Seishi}, year = {2025}, journal = {Blood}, volume = {146}, number = {Suppl. 1}, pages = {5005--5006}, doi = {10.1182/blood-2025-5005}, url = {2036694}, language = {eng}, publisher = {Elsevier}, abstract = {Background: Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease. While traditional classification systems such as FAB relied on morphology and immunophenotype, recent classifications (WHO, ICC) emphasize genetic alterations for diagnosis and therapy. However, more directly involved in the phenotypic cellular inheritance, the epigenomic profile may offer an additional dimension for understanding AML heterogeneity. Previously, we performed ATAC-seq of 1,536 AML samples and identified 16 epigenetically defined AML subgroups (subgroups A-P), which were associated with distinct clinical, genetic, and transcriptional features (Ochi et al., ASH 2024). In the present study, we extend these findings by using single-cell RNA and ATAC-seq (scRNA/ATAC-seq) profiling to explore intra- and inter-tumor epigenetic heterogeneity, transcriptional regulation, and hierarchical differentiation trajectories across AML subgroups.Methods: We performed multi-platform scRNA/ATAC-seq on 36 AML samples including all the 16 epigenomic subgroups and 4 remission samples (as controls), profiling a total of 281,167 mononuclear cells. Computational analyses included cell clustering, projection onto normal hematopoiesis reference maps, pseudotime inference, transcription factor (TF) activity analysis using SCENIC+, and leukemic stem cell (LSC) signature scoring.Results: scATAC-based clustering showed that leukemic cells from individual AML samples formed distinct clusters largely separated from normal cells, typically co-clustered by subgroup, regardless of their differentiation status, indicating that leukemic cells within each subgroup share a distinct intrinsic epigenetic program. Projection onto a normal hematopoiesis reference map revealed divergent differentiation arrest among subgroups, even within genetically similar cases. For instance, all NPM1-mutant subgroups (D–F) were HOX-related but differed in differentiation states: subgroup E was arrested at the HSC stage, D at the GMP stage, and F contained both progenitors and mature cells. Single-cell analysis also refined differentiation states of subgroups F-H: while bulk ATAC-based deconvolution suggested monocyte enrichment in these subgroups, single-cell analysis revealed mature monocytes predominated in H, whereas F and G were enriched for immature promonocytes.Combined with LSC signature analysis based on gene expression, pseudotime analysis demonstrated that cells showing high LSC scores consistently mapped to early stages of the differentiation trajectory across all subgroups. These results indicate the presence of a conserved leukemic hierarchy, with stem-like cells positioned at the apex, irrespective of epigenetic subgroup, thereby underpinning AML pathogenesis. We further analyzed TF activity using the SCENIC+ program based on scRNA/ATAC-seq data, which identified key TFs enriched in each subgroup, many of which overlapped with those found in bulk RNA/ATAC-seq analysis. Pseudotime analysis further showed that TFs exhibited subgroup-specific activation dynamics. For example, HOXA9 was activated throughout the myeloid differentiation trajectory in HOX-related subgroups but peaked at different stages according to subgroups. In the RUNX1-enriched subgroup, IRF8 and BCL11A were both active but peaked at mature and immature stages, respectively. These findings indicate that key TFs exhibit subgroup-specific activation patterns at distinct stages along the myeloid differentiation trajectory.Conclusion: Single-cell multi-omics analysis reveals that AML epigenetic subgroups exhibit distinct but hierarchically organized differentiation trajectories, driven by dynamically regulated TF programs. These findings refine our understanding of AML diversity and may inform more precise, differentiation-stage–specific therapeutic strategies.}, issn = {0006-4971} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_mazurstepan_2025_3, title = {Singular Wishart distribution and its Applications to Discriminant Analysis and Portfolio Theory}, author = {Mazur, Stepan}, year = {2025}, url = {1959458}, language = {eng} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_nergeliusjoakim_2025_3, title = {Skadestånd vid rättighetskränkning : ett nytt centralt konstitutionellt rättsområde}, author = {Nergelius, Joakim}, year = {2025}, pages = {201--212}, url = {2032214}, language = {swe}, publisher = {Iustus förlag}, keywords = {violation of fundamental rights; financial compensation; tort law; judicial power}, abstract = {An attempt to describe the new legal situation after a change in the Tort Law in 2022, which means that any violation of the fundamental rights in the Swedish constitution and the European Convention of Human Rights from the public authorities may lead to financial compensation.} } @book{ca0f099bbf2a435cee8f97bef5e8cbaa_nilssonpeter_2025, title = {Skattehandboken 2025}, author = {Nilsson, Peter and Lynda, Ondrasek Olofsson and David, Kleist and Kristoffersson, Eleonor}, year = {2025}, url = {2031809}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Skattehandboken är en komplett handbok för företagsbeskattning, personbeskattning och moms som fyra gånger om året uppdateras med aktuella bestämmelser. Skattehandboken vänder sig till alla som arbetar med skattefrågor. Det är ett självklart hjälpmedel för varje skattekonsult, ekonomiavdelning, revisor eller redovisningskonsult.De två handbokspärmarna behandlar företagets inkomstbeskattning, d.v.s frågor som rör beräkningen av ett företags skattepliktiga inkomst. Innehållet har disponerats så att det knyter an till företagets resultaträkning, men här behandlas också frågor som dels rör den personliga beskattningen, dels företagets hantering av sociala avgifter, skatteuppbörd m.m. Momsområdet ägnas stort utrymme, liksom internationella skattefrågor.Skattehandboken finns även som onlineprodukt och då får du dessutom:- Praktisk sökfunktion- Tillgång till ett blankettarkiv med över 100 interaktiva blanketter från Skatteverket som kan fyllas i direkt på skärmen och sedan skrivas ut och signeras eller sparas ner för senare bearbetning.- Fulltextversioner av de viktigaste lagarna på skatteområdet men också områdena redovisning och associationsrätt.- Tillgång till nya skattedomar från Regeringsrätten.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_26, title = {Skattereduktion för dubbelriktad laddbox}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031689}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 3 mars 2025 meddelade Skatterättsnämnden ett förhandsbesked om skattereduktion för grön teknik vid installation av en dubbelriktad laddningspunkt för elfordon (diarienummer 58-24/D) Eleonor Kristoffersson, professor i skatterätt, analyserar förhandsbeskedet.} } @book{ca0f099bbf2a435cee8f97bef5e8cbaa_hiortafornsleijonlena_2025, title = {Skattesystemet. Lärobok : Inkomstskatt, sociala avgifter, mervärdesskatt, punktskatter, internationella frågor och förfarande}, author = {Hiort af Ornäs Leijon, Lena and Kristoffersson, Eleonor}, year = {2025}, url = {1931209}, language = {swe}, publisher = {Iustus förlag}, abstract = {Skattesystemet påverkar alla. Ett stort antal skatteregler skapar tillsammans detta skattesystem, vilket medför att det är en utmaning att skaffa sig en överblick över helheten.Ambitionen med denna bok är att på ett lättillgängligt sätt ge en överblick över, inblick i och förståelse för hela skattesystemet. Boken behandlar därför skattesystemets samtliga delar, dvs. inkomstskatt, sociala avgifter, mervärdesskatt, punktskatter, trafikskatter, internationella frågor och förfarande.Boken är skriven som en lärobok och kan i undervisnings- och inlärningssammanhang med fördel kompletteras med Skattesystemet. Övningsbok. Den kan också användas som introduktionsbok och kompletteras med andra läroböcker som ger en fördjupning i exempelvis inkomstskatt och mervärdesskatt. Ett ytterligare sätt att använda den är att komplettera den med den uppsjö av material som finns fritt tillgängligt på exempelvis Skatteverkets webbplats, samt med rättsfall och förarbeten. Slutligen kan den användas helt fristående som enda kursbok på kurser där skatterätten utgör en mindre del.} } @book{ca0f099bbf2a435cee8f97bef5e8cbaa_hiortafornsleijonlena_2025_1, title = {Skattesystemet : Övningsbok}, author = {Hiort af Ornäs Leijon, Lena and Kristoffersson, Eleonor}, year = {2025}, url = {1931210}, language = {swe}, publisher = {Iustus förlag}, abstract = {Denna övningsbok i skatterätt innehåller mer än 120 övningsuppgifter med svar som är utförligt kommenterade. Den hjälper användaren att ta steget från teori till tolkning och tillämpning. Den skapar förutsättningar för en fördjupad förståelse för och överblick över skattesystemets samtliga delar, såsom inkomstskatt, moms och punktskatter. I undervisnings- och inlärningssammanhang kan övningsboken kompletteras med Skattesystemet. Lärobok som följer samma disposition. Förutom i undervisning kan boken användas av alla som i yrkes- eller privatliv kommer i kontakt med skatter och som vill fördjupa sina kunskaper om skattesystemet.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_grahamtanya_2025, title = {Skin cleansers and leave-on product interventions for preventing incontinence-associated dermatitis in adults}, author = {Graham, Tanya and Beeckman, Dimitri and Kottner, Jan and Fader, Mandy and Fiorentino, Francesca and Fitzpatrick, Joanne M. and Gray, Mikel and Harris, Ruth G. and Sooriah, Sangeeta and Wallace, Sheila A. and Worsley, Peter R. and Woodward, Sue}, year = {2025}, journal = {Cochrane Database of Systematic Reviews}, volume = {7}, number = {7}, doi = {10.1002/14651858.CD011627.pub3}, url = {1989828}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {bias; dermatitis [etiology] [prevention & control]; fecal incontinence [complications]; quality of life; randomized controlled trials as topic; skin care [methods]; urinary incontinence [complications]}, abstract = {BACKGROUND: Incontinence-associated dermatitis (IAD) is a common skin problem in adults with urinary incontinence, faecal incontinence, or both. Prevention involves skin care interventions such as skin cleansing and the application of skin protectants/barriers (leave-on products).OBJECTIVES: To assess the effects of skin care cleansers, leave-on products, and procedures for preventing incontinence-associated dermatitis in adults.SEARCH METHODS: On 29 April 2024, we searched the Cochrane Incontinence Specialised Register - which includes searches of CENTRAL, MEDLINE, MEDLINE In-Process, MEDLINE Epub Ahead of Print, ClinicalTrials.gov, and WHO ICTRP - and hand-searched journals and conference proceedings. We searched reference lists of included studies to identify additional studies.SELECTION CRITERIA: We selected randomised controlled trials (RCTs) and quasi-RCTs conducted in any healthcare setting and involving participants aged over 18 years without IAD at baseline. We included trials comparing the effectiveness of skin cleansing interventions and leave-on products or combinations of interventions/leave-on products.DATA COLLECTION AND ANALYSIS: Three review authors independently screened the titles, abstracts, and full-text articles. Four review authors independently extracted data and assessed risk of bias. Data from studies not published in English were translated and extracted by volunteers from Cochrane Engage and the review authors' networks. Primary outcomes were: number of participants with IAD and adverse effects related to the intervention (pain, skin rash, itching, and other serious adverse effects). Secondary outcomes were: number of participants satisfied with skin care products or procedures, adherence to the protocol throughout the intervention, and quality of life (condition-specific or generic). We used GRADE to assess the certainty of the evidence.MAIN RESULTS: We included 15 trials with 1020 participants in a qualitative synthesis (41 participants from nursing homes; 65 from both care homes and hospital, and 914 from hospital settings). Participants had urinary incontinence, faecal incontinence, or both. Thirteen trials had small sample sizes and two trials had 180 and 174 participants. Six trials assessed outcomes in the short term (≤ 7 days), four in the medium term (8 days-1 month), and one in the long term (> 1 month-3 months). In the remaining studies, the timing of assessment was unclear. The overall risk of bias in the included studies was high. Substantial heterogeneity (in study populations, skin care products, skin care procedures, outcomes, and measurement tools) precluded meta-analysis. Three trials compared skin cleansing interventions, and five trials compared leave-on products or a combination of leave-on products. Seven trials compared a combination of skin cleansers and leave-on products.Number of participants with incontinence-associated dermatitisThree trials compared a skin cleanser with soap and water. One provided evidence that using a foam cleanser might be more effective than soap and water for preventing IAD (RR 0.35, 95% CI 0.14 to 0.85; 65 participants; very low-certainty evidence), while another found little or no difference in effectiveness between a disposable washcloth containing 3% dimethicone and soap and water (RR 0.14, 95% CI 0.01 to 2.28; 12 participants; very low-certainty evidence). The third trial reported lower erythema scores with a no-rinse skin cleanser compared with soap and water, but we were unable to analyse these data. In trials evaluating combinations of skin cleansers and leave-on products versus skin cleansing alone, one suggested the combined treatment may be more effective for preventing IAD (RR 0.03, 95% CI 0.00 to 0.53; 180 participants; very low certainty of evidence), and the other showed little to no difference between interventions (RR 0.71, 95% CI 0.14 to 3.68; 31 participants; very low-certainty evidence). Two studies showed little to no difference between a combination of leave-on products versus a single product (RR 0.85, 95% CI 0.36 to 2.02; 74 participants; very low-certainty evidence); (RR 0.25, 95% CI 0.03 to 1.86; 20 participants; very low-certainty evidence). In general, we cannot draw meaningful conclusions about the effectiveness of the tested interventions in preventing IAD because of the very low certainty of the evidence for all comparisons.ADVERSE EFFECTS: painOne trial found that fewer people using a combination of skin cleansing and a leave-on product experienced pain compared with those receiving cleansing without a leave-on product (RR 0.33, 95% CI 0.09 to 1.19; 180 participants; low-certainty evidence), and one trial found that fewer people using a no-rinse skin cleanser plus a skin cream developed pain compared with those using soap and water followed by a lotion (RR 0.58, 95% CI 0.19 to 1.74; 31 participants; low-certainty evidence). However, our analyses of these two comparisons suggest there may be little to no difference between the tested interventions in terms of associated pain.ADVERSE EFFECTS: itchingOne trial found that skin cleansing and a leave-on product may be less frequently associated with itching compared with a conventional skin care regimen with no leave-on product (RR 0.04, 95% CI 0.01 to 0.29; 180 participants; low-certainty evidence).AUTHORS' CONCLUSIONS: We found limited evidence, of low and very low certainty, on the effectiveness of interventions for preventing IAD in adults. Consequently, it is unclear whether any skin cleanser or leave-on product, used alone or in combination, performs better than any other. There is some very uncertain evidence that using a skin cleanser may be better at preventing IAD than soap and water, and that using a combination of a skin cleanser with a leave-on product may be better at preventing IAD than using a skin cleanser alone. There is a need for high-quality confirmatory trials using standardised, comparable prevention regimens in different settings/regions.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bauduccoserena_2025, title = {Sleep trajectories and frequency of non-suicidal self-injury in adolescents : a person-oriented perspective over two years}, author = {Bauducco, Serena and Tilton-Weaver, Lauree and Gradisar, M. and Hysing, M. and Latina, Delia}, year = {2025}, journal = {Scientific Reports}, volume = {15}, number = {1}, doi = {10.1038/s41598-025-85779-5}, url = {1926492}, language = {eng}, publisher = {Nature Publishing Group}, keywords = {person-oriented analyses; self harm; sleep disturbance; teenagers}, abstract = {Adolescent sleep quality and quantity is commonly linked to worse emotion regulation. One maladaptive emotion regulation strategy that is on the rise is non-suicidal self-injury (NSSI), which includes burning, hitting, or scratching one's own body tissue without suicidal intent. The aim of this study was to explore the frequency of NSSI among different longitudinal trajectories of insomnia symptoms and short sleep duration to identify at-risk adolescents. We used questionnaire data collected annually (3 time points over 2 years) from a sample of Swedish adolescents (N = 1,294; Mage = 13.2 [range: 12-15 years], SD = 0.4; 46.8% girls). Adolescents answered questions about their sleep duration, symptoms of insomnia, NSSI, depressive symptoms, and demographics. Adolescents who reported persistent or increasing sleep problems over time also reported more NSSI. A notable pattern was that adolescents whose insomnia symptoms were high and increasing reported the highest frequency of NSSI, also compared to adolescents who started at the same high level of insomnia symptoms but improved over time. Therefore, measuring NSSI may help identify a risk-group for persistent sleep problems and self-injury. Because sleep disturbances, especially insomnia, and NSSI go hand-in-hand for most adolescents, sleep interventions would benefit the treatment and prevention of self-injury.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stresirijakobsson_2025_1, title = {Sleepless in cyberspace : A thematic analysis of online sleep recommendations for insomnia symptoms}, author = {Störe, Siri Jakobsson and Milutinovic, Ena and Landén, Frida Sjökvist and Norell, Annika}, year = {2025}, journal = {Sleep Health}, volume = {11}, number = {5}, doi = {10.1016/j.sleh.2025.04.008}, url = {1968819}, language = {eng}, publisher = {Elsevier}, keywords = {advice; insomnia; internet forum; qualitative; sleep; thematic analysis}, abstract = {OBJECTIVES: Insomnia is the most common sleep disorder in adults. About 10% of adults meet the diagnostic criteria, and about 30% suffer from subclinical symptoms. Seeking advice online is common when having health issues. There are no previous studies on Swedish Internet forums regarding types of advice and the logic behind the recommendations given for how to handle troubled sleep. The purpose of the study was to examine which treatment methods for insomnia symptoms were recommended by forum users on the Swedish Internet forum Flashback.METHODS: A thematic analysis was conducted on 1174 posts.RESULTS: The analysis resulted in four themes: (1) Advice on healthcare, (2) Bedtime and sleep environment strategies, (3) Implement long-term lifestyle changes, and (4) Advice on nonprescribed, legal, or illegal drugs. Notably, a large portion of the recommendations provided emphasized the utilization of pharmacological interventions, including prescription drugs, over-the-counter medications, supplements, illegal substances, or combinations of these. This despite the fact that many advice givers attributed insomnia to psychological causes such as stress.CONCLUSIONS: Insight into recommendations given on Internet forums is important for healthcare personnel; advice might shape patients' sleep habits as well as expectations on insomnia treatments.}, issn = {2352-7218} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_scanderhenrik_2025_1, title = {Smakens dirigent : Sommelierens estetiska hantverk och smakens kulturella sammanhang}, author = {Scander, Henrik}, year = {2025}, journal = {Livets goda : Sveriges vintidning No 1 - med whisky, mat, öl & musik}, number = {184}, pages = {14--15}, url = {2016272}, language = {swe}, publisher = {Livets goda}, abstract = {Smak är aldrig enbart en fråga om biologi. Det är en rik och sammansatt erfarenhet, formad av vår kropp, våra erfarenheter, våra kulturella referensramar, och inte minst av dem som tolkar, förmedlar och ramar in smaken. I min forskning står sommelieren, denna ofta romantiserade men dåligt förstådda yrkesroll, i centrum för en fördjupad förståelse av hur smak formas, iscensätts och ges mening i samtida måltidskulturer.}, issn = {1652-7615} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kaplanlewisj_2025, title = {Small bowel obstruction outcomes according to compliance with the World Society of Emergency Surgery Bologna guidelines}, author = {Kaplan, Lewis J. and Martinez-Casas, Isidro and Mohseni, Shahin and Cimino, Matteo and Kurihara, Hayato and Lee, Matthew J. and Bass, Gary Alan}, year = {2025}, journal = {British Journal of Surgery}, volume = {112}, number = {4}, doi = {10.1093/bjs/znaf080}, url = {1954501}, language = {eng}, publisher = {Oxford University Press}, abstract = {BACKGROUND: Small bowel obstruction (SBO) is a common surgical emergency associated with substantial morbidity, hospital length of stay (LOS), and healthcare cost. The World Society of Emergency Surgery (WSES) Bologna guidelines provide evidence-informed recommendations for managing adhesive SBO, promoting timely surgical intervention (or non-operative management (NOM) when ischaemia, strangulation, or peritonitis are absent). However, guideline adoption and its impact on outcomes remain under studied. Compliance with the Bologna guidelines was evaluated to determine the impact of compliance on outcomes.METHODS: SnapSBO, a prospective, multicentre, time-bound, observational cohort study, captured data on patients with adhesive SBO across diverse healthcare settings and patient populations. Patient care was categorized into: successful NOM, surgery after an unsuccessful appropriate trial of NOM (NOM-T), and direct to surgery (DTS). Compliance with diagnostic, therapeutic, and postoperative Bologna guideline recommendations was assessed as either complete or partial. Primary outcomes included adherence to the Bologna guidelines, LOS, complications, and the incidence of the composite metric 'optimal outcomes' (LOS ≤5 days, discharge without complications, and no readmission within 30 days).RESULTS: Among 982 patients with adhesive SBO, successful NOM occurred in 561 (57.1%), 224 (22.8%) underwent NOM-T, and 197 (20.1%) proceeded DTS. The mean(s.d.) LOS was 5.3(9.0), 12.9(11.4), and 7.7(8.0) days respectively (P < 0.001). Optimal outcomes were achieved in 61.0%, 16.1%, and 37.6% respectively (P < 0.001) and full guideline compliance was observed in 17.2%, 10.1%, and 0.4% respectively.CONCLUSION: Patients with adhesive SBO whose care was aligned with the Bologna guidelines had a shorter LOS and a greater incidence of optimal outcomes. Addressing evidence-to-practice gaps through implementation strategies that consider contextual factors will enhance guideline adoption and patient outcomes.}, issn = {0007-1323} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_enlfper_2025, title = {Smart glasses for monitoring vital signs in anaesthesia care settings : a qualitative simulation study}, author = {Enlöf, Per and Sjöberg, Carina and Ringdal, Mona and Lindgren, Sophie and Wolf, Axel and Jildenstål, Pether}, year = {2025}, journal = {BMC Anesthesiology}, volume = {25}, number = {1}, doi = {10.1186/s12871-025-03501-4}, url = {2018136}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {anaesthesia care; anaesthesia monitoring; patient safety; qualitative research; simulation training; smart glasses; vital signs monitoring}, abstract = {BACKGROUND: Monitoring of vital signs is essential in anaesthesia care and plays a key role in preventing adverse events. Technological innovation is recognised as an important factor in enhancing patient safety. Smart glasses represent a novel tool that may support anaesthesia professionals in monitoring vital signs; however, their practical use and user experiences in anaesthesia care remain insufficiently explored. Understanding anaesthesia healthcare professionals' experiences with this technology is crucial to ensure its safe and effective implementation. In this study, smart glasses from Microsoft HoloLens 2 were used to visualize vital signs in the user's field of vision. The aim was to explore anaesthesia health care professionals' experience of using Microsoft HoloLens 2 smart glasses for monitoring vital signs in various simulated anaesthesia care scenarios.METHODS: A qualitative study design was used to explore the experiences of nurse anaesthetists and anaesthesiologists. Data were gathered through focus group interviews and subsequently analysed using qualitative content analysis.RESULTS: One overarching theme - a positive yet cautious attitude towards smart glasses - was identified, comprising three categories: Impact on intraoperative monitoring, Usability of the smart glass technology, and Communication challenges. These categories illustrated both advantages and limitations of using smart glasses in simulated anaesthesia care scenarios.CONCLUSIONS: The experience of using Microsoft HoloLens 2 for monitoring vital signs in simulated anaesthesia care scenarios revealed a generally positive but careful attitude towards the technology. Participants appreciated its potential to enhance situational awareness through continuous access to vital signs, while also highlighting concerns related to ergonomics, restricted field of view, and possible distraction. The findings offer insights for developers aiming to optimise smart glasses for clinical use. Further refinement and evaluation in clinical settings are needed before broader implementation in anaesthesia practice.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dahlgrenaxel_2025, title = {Smoking and Coronary Atherosclerosis : Disproportionate Impact on the Right Coronary Artery}, author = {Dahlgren, Axel and Erlinge, David and Torii, Ryo and Yong, Enhui and Bergström, Göran and Jernberg, Tomas and Fröbert, Ole and Thrane, Pernille G. and Mæng, Michael and Stone, Gregg W. and Mohammad, Moman A.}, year = {2025}, journal = {Journal of the Society for Cardiovascular Angiography & Interventions}, volume = {4}, number = {8}, doi = {10.1016/j.jscai.2025.103609}, url = {2002299}, language = {eng}, publisher = {Elsevier}, keywords = {coronary artery atherosclerosis; natural progression; smoking}, abstract = {BACKGROUND: We aimed to study the long-term effect of smoking on coronary atherosclerosis progression at the segmental level.METHODS: Angiographic data (1989-2017) on current, former, and nonsmokers were collected from the Swedish Coronary Angiography and Angioplasty Registry. The Western Denmark Heart Registry was used to validate the results. Patients with clinically indicated angiography with ≥2 coronary arteries without obstructive coronary artery disease were included. The main outcome was segmental plaque progression, percutaneous coronary intervention, or coronary artery bypass grafting within 15 years.RESULTS: In total, 215,364 Swedish patients with 993,405 coronary arteries (left anterior descending artery [LAD], left circumflex artery [LCX], and right coronary artery [RCA]) were included. The validation cohort consisted of 19,613 patients. Per 1000 patient-years, plaque progression incidence rate was 11.3 (95% CI, 10.9-11.7) for smokers, 10.2 (95% CI, 9.9-10.5) for former smokers, and 7.7 (95% CI, 7.5-7.9) for nonsmokers. Smokers demonstrated higher relative risk of plaque progression in RCA (hazard ratio, 1.87; 95% CI, 1.73-2.03) vs LAD (hazard ratio, 1.21; 95% CI, 1.12-1.30). Swedish and Danish smokers with ST-segment elevation myocardial infarction had higher proportion of RCA as the culprit artery compared to nonsmokers (smokers: RCA, 42.4%; LAD, 42.0%; LCX, 15.6%; nonsmokers: RCA, 33.1%; LAD, 51.4%; LCX, 15.5%).CONCLUSIONS: This observational cohort study identifies distinct differences in plaque progression patterns between smokers and nonsmokers, with smoking linked to increased plaque progression in the RCA, in contrast to the LAD in nonsmokers. These findings reemphasize the need for targeted smoking prevention and warrant further investigation into RCA-specific mechanisms of plaque progression and MI.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_berglundkarin_2025_1, title = {Social entrepreneurship from margin to centre : Rear Admiral Grace Murray Hopper's contributions in transforming society through practices of opening up}, author = {Berglund, Karin and Pecis, Lara}, year = {2025}, journal = {Business History}, doi = {10.1080/00076791.2025.2570775}, url = {2013296}, language = {eng}, publisher = {Routledge}, keywords = {social entrepreneurship; practices of opening up; entrepreneurial state; wwii; grace murray hopper; social transformation; margin/centre; jennifer aston}, abstract = {This article explores social entrepreneurship (SE) historically, focusing on the interplay between the US entrepreneurial state, WWII geopolitics, and shifting gender roles. Drawing on the historiography of Rear Admiral Grace Murray Hopper, it traces how SE has historically unfolded as a collective, collaborative, and open endeavour capable of driving social transformation. Hopper's work in computing reveals three situated SE practices: stepping into the labour market, engaging in creative problem-solving in the margins, and building community through reaching out. By engaging bell hooks's concept of the margin as a space of radical openness, the article shows how women were granted access to centre in ways that redefined possibilities for transformation. Hopper's SE made programming languages accessible rather than monopolised systems and challenged gendered boundaries in the ICT field. The article highlights the changing meanings of SE over time and reclaims its roots in democratic, inclusive practices that enable broader social transformations.}, issn = {0007-6791} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_kremelanna_2025_1, title = {Social innovation i samspel : Aktörsdrivna metoder och stödstrukturer i det svenska ekosystemet för socialt entreprenörskap}, author = {Kremel, Anna and Segerstedt, Eugenia}, year = {2025}, url = {2017982}, language = {swe}, keywords = {sociala företag; innovation; samverkan}, abstract = {Regeringens strategi för socialt företagande och social innovation har lagt en stabil grund för att samla aktörer från olika sektorer. Samtidigt är kunskapen begränsad om hur stödsystemet för sociala entreprenörer och innovation faktiskt samskapas (Tengqvist, Lindberg & Lopéz, 2022). Denna studie fokuserar på samspelet mellan stödsystemet, sociala entreprenörer och intermediärer, med särskilt fokus på hur aktörer tillsammans identifierar behov, utvecklar kunskap och formar lösningar.Syftet är att fördjupa förståelsen för det svenska ekosystemets stöd till socialt företagande och innovation, samt att undersöka hur samskapande sker i praktiken inom detta system. Studien bygger på djupintervjuer med centrala aktörer i ekosystemet. Det teoretiska ramverket utgår från Ecosystem Approach to Social Innovation (Nicholls & Murdock, 2012), där social innovation ses som ett resultat av relationer och samverkan mellan aktörer och resurser.Studien relaterar till den svenska delrapporten av European Social Enterprise Monitor (Mötesplats Social Innovation, 2024), där samskapande med ekosystemets aktörer i datainsamling, analys och gemensamt lärande – genom presentation, diskussion och reflektion – bidrog till ökad relevans och användbarhet för ekosystemets fortsatta arbete. Studien bidrar med insikter om hur samskapande kan stärka ekosystemets förmåga att stödja sociala entreprenörer och utveckla innovativa lösningar på samhällsutmaningar.Referenser:Nicholls, A., & Murdock, A. (2012). The nature of social innovation. In Social innovation: Blurring boundaries to reconfigure markets (pp. 1-30). London: Palgrave Macmillan UK.Tengqvist, Lindberg & Lopéz (2022). The social innovation ecosystem in Sweden. Requriements and challenges for promotion of social innovation in Sweden. BuiCaSuS 2021-2023.  } } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_jmtejan_2025_3, title = {Sociala rörelser i Sverige : politiska protester och aktivism från 1945 till i dag}, author = {Jämte, Jan and Lundstedt, Måns and Wennerhag, Magnus}, year = {2025}, url = {1967840}, language = {swe}, publisher = {Studentlitteratur AB}, keywords = {sociala rörelser; politisk aktivism; politiska protester; svensk historia; demokrati}, abstract = {Sociala rörelser har spelat en viktig roll i många av de samhällsförändringar som präglat Sverige efter andra världskriget. Rörelserna har fört upp nya frågor på samhällets dagordning, ifrågasatt dominerande normer och formulerat nya framtidsvisioner långt innan de spridits bland befolkningen i stort. De sociala rörelsernas betydelse har inte minskat med tiden – tvärtom har olika former av politisk aktivism tilltagit i intensitet sedan 1945, samtidigt som medborgarnas engagemang i politiska partier har avtagit.Boken Sociala rörelser i Sverige introducerar femton sociala rörelser som varit betydelsefulla i Sverige från 1945 och fram till i dag, från fackföreningsrörelsen, kvinnorörelsen och miljörörelsen till den radikal­nationalistiska rörelsen, djurrättsrörelsen och ortenrörelsen. Boken belyser vilka frågor rörelserna uppmärksammat, hur de försökt påverka politik och samhällsdebatt, vilka idéer och visioner som varit centrala för deras agerande, hur de organiserat sig och inte minst vilken betydelse de har haft för det svenska samhällets utveckling. I boken introduceras också de teorier och begrepp som används i forskningen om sociala rörelser. De medverkande författarna är forskare i sociologi, statsveten­skap, historia, socialt arbete, etnologi och religionshistoria. Boken vänder sig till studenter och forskare inom samhällsvetenskap och humaniora samt till alla som intresserar sig för det svenska samhällets utveckling.} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_argrenrigmor_2025, title = {Socialisering i upplevelsebaserad undervisning : En genomgång av Bolagsspelet 2003–2019}, author = {Argren, Rigmor}, year = {2025}, url = {1943386}, language = {swe}, publisher = {Örebro universitet}, file = {https://oru.diva-portal.org/smash/get/diva2:1943386/FULLTEXT01.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_argrenrigmor_2025_1, title = {Socialisering i upplevelsebaserad undervisning : En genomgång av Bolagsspelet 2003-2019}, author = {Argren, Rigmor}, year = {2025}, pages = {29--53}, url = {2002927}, language = {swe}, publisher = {Iustus förlag} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_brauerjohn_2025_2, title = {Socialpolitik}, author = {Brauer, John}, year = {2025}, pages = {119--137}, url = {1959520}, language = {swe}, publisher = {Santérus Förlag} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_farhatluisc_2025_1, title = {Sociodemographic and clinical characteristics of 1,234 individuals diagnosed with trichotillomania in the Swedish National Patient Register}, author = {Farhat, Luis C. and Isomura, Kayoko and Fernández de la Cruz, Lorena and Sidorchuk, Anna and Kuja-Halkola, Ralf and Brikell, Isabell and Chang, Zheng and D'Onofrio, Brian M. and Larsson, Henrik and Lichtenstein, Paul and Mataix-Cols, David}, year = {2025}, journal = {Scientific Reports}, volume = {15}, number = {1}, doi = {10.1038/s41598-025-95416-w}, url = {1948229}, language = {eng}, publisher = {Nature Publishing Group}, keywords = {body-focused repetitive behaviors; disruptive; impulse control; and conduct disorders; hair-pulling disorder; obsessive–compulsive disorder; population registers}, abstract = {Trichotillomania is an understudied, underrecognized, and difficult-to-treat psychiatric disorder that affects about 1-2% of the population, predominantly women. This study aimed to characterize the sociodemographic and clinical characteristics of a Swedish cohort of individuals with a diagnosis of trichotillomania assigned in specialist services across the country. Through the Swedish National Patient Register, we identified all individuals with an ICD-10 diagnosis of trichotillomania between January 1st, 1997 and December 31st, 2020. The cohort included 1,234 individuals, with a median age at first diagnosis of 25 years (interquartile range, 16-35). Most individuals were female (85%) and single (82%). Most (79%) individuals had a comorbid psychiatric disorder diagnosed during the study period. Anxiety-related disorders (65%), depressive disorders (48%), and neurodevelopmental disorders (39%) were the most frequent co-occurring diagnoses. Most (72%) individuals were dispensed psychotropic medications during the period ranging from 12 months prior to and 12 months after the first trichotillomania diagnosis. Antidepressants (58%), hypnotics/sedatives (36%), and anxiolytics (31%) were the most frequently dispensed medications. Altogether, the characteristics of individuals diagnosed with trichotillomania in Swedish specialist services were similar to those reported in previous literature, opening the possibility of register-based research into this underdiagnosed and understudied condition.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jakobssonhugo_2025_1, title = {Socioeconomic factors associated with poor patient-reported outcomes of 17,478 patients after a distal radial fracture}, author = {Jakobsson, Hugo and Möller, Michael and Cao, Yang and Lundqvist, Eva and Wretenberg, Per and Sagerfors, Marcus}, year = {2025}, journal = {Journal of Hand Surgery, European Volume}, volume = {50}, number = {7}, pages = {956--964}, doi = {10.1177/17531934241293426}, url = {1910411}, language = {eng}, publisher = {Sage Publications}, keywords = {comorbidity; short musculoskeletal function assessment; country of birth; distal radial fracture; socioeconomic factors; wrist fracture}, abstract = {This study aimed to investigate the association of socioeconomic factors, country of birth and comorbidities with poor patient-reported outcome 1 year after a distal radial fracture. The patient population was obtained from the Swedish Fracture Register. In the study, 17,468 patients 18 years or older were included. Poor outcome was the dependent variable in a multivariate logistic regression analysis. The factors with the strongest association with poor outcome were country of birth outside the European Union (odds ratio (OR) = 2.28; 95% CI = 1.91-2.73), high-energy trauma mechanism (OR = 1.76; 95% CI = 1.46-2.12), a history of anxiety or depression (OR = 1.46; 95% CI = 1.26-1.70), and a Charlson comorbidity index ≥3 (OR = 1.51; 95% CI = 1.17-1.94). Alleviating the effects of these factors could potentially decrease the proportion of patients with a disability after a distal radial fracture.Level of evidence: III.}, issn = {1753-1934} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bengtssondaniel_2025, title = {Socioeconomic status and its association with outcome in patients with Cushing's disease}, author = {Bengtsson, Daniel and Järås, Jacob and Burman, Pia and Wahlberg, Jeanette and Ragnarsson, Oskar}, year = {2025}, journal = {European Journal of Endocrinology}, volume = {192}, number = {3}, pages = {159--169}, doi = {10.1093/ejendo/lvaf021}, url = {1947103}, language = {eng}, publisher = {Oxford University Press}, keywords = {cushing's disease; socioeconomic; educational level; disability pension; pituitary adenoma}, abstract = {Objective: Cushing's disease (CD) is associated with severely impaired quality of life and shortened life expectancy. Little is known about the socioeconomic consequences of CD and their impact on long-term outcome.Methods:This was a nationwide study including 371 patients with CD (76% women), diagnosed between 1991 and 2018, and 4 matched controls per patient from the background population. Clinical data were retrieved from the national Swedish pituitary register and socioeconomic data were collected from national Swedish registers from up to 20 years before and up to 20 years after diagnosis.Results: The proportion of patients receiving disability pensions was increased, starting 6 years before diagnosis, and increased further thereafter, mainly due to mental and musculoskeletal disorders, to reach around 20%-25% during long-term follow-up. Low educational level in patients with CD was associated with lower rates of employment and increased mortality (adjusted hazard ratio 2.5, 95% CI 1.1-5.4).Conclusions: CD is associated with low socioeconomic status that is already noticeable 6 years before diagnosis and remains high during follow-up. Low socioeconomic status, in particular low educational level, is associated with adverse outcome. The findings indicate a need for proactive rehabilitation plans as part of standard management.}, issn = {0804-4643} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_kolkowskaella_2025, title = {Socio-Technical Transformation of Elderly-Care with Data-Driven Decision-Making : An Umbrella Review}, author = {Kolkowska, Ella and Hanif, Muhammad}, year = {2025}, volume = {4134}, url = {2028951}, language = {eng}, publisher = {Technical University of Aachen}, keywords = {elderly care; socio-technical system; data-driven-decision making; digital transformation}, abstract = {This umbrella literature review is driven by the pressing need for research to transform the elderly care sector, which is challenged by a rapidly ageing population and constrained resources. In this context, data-driven decision-making emerges as a promising approach to facilitate the necessary transformation. The aim this this review was to explore how socio-technical aspects are discussed in research on the use of data-driven decision-making in elderly care settings. Our analysis suggests that the majority of current research places disproportionate focus on technological development while neglecting the social, structural, and systemic contexts that are critical for successful and sustainable implementation. A more balanced and contextually aware approach—grounded in socio-technical systems thinking—is essential to advance the field and ensure that digital innovations truly enhance elderly care.}, file = {https://oru.diva-portal.org/smash/get/diva2:2028951/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_volgstenulrik_2025_4, title = {Solitary Listening, Copyright, and Reification during the Interwar Years : A Discourse Theoretic Approach}, author = {Volgsten, Ulrik}, year = {2025}, journal = {Twentieth Century Music}, volume = {22}, number = {2}, pages = {171--192}, doi = {10.1017/S1478572224000082}, url = {1895594}, language = {eng}, publisher = {Cambridge University Press}, issn = {1478-5722} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_glombikdominik_2025, title = {Soluble immune inhibitory checkpoint proteins : Potential liquid biopsy biomarkers for penile cancer}, author = {Glombik, Dominik and Carlsson, Jessica and Kirrander, Peter and Davidsson, Sabina}, year = {2025}, journal = {European Urology}, volume = {87}, number = {Suppl. 1}, url = {2007968}, language = {eng}, publisher = {Elsevier}, abstract = {Introduction & Objectives: Immune checkpoint proteins are recognized as critical regulators of the immune system and play an important role in the defence against cancer. Unfortunately, cancer cells evade the immune destruction by overexpressing inhibitory checkpoint proteins, hence creating a favourable tumour microenvironment. Recently, it has been proposed that immune checkpoint proteins can be detected in soluble form in body fluids. This is important since a blood sample is less invasive than a tissue sample and hypotheticall yhas the potential to be more representative. The aim of the study was to evaluate the concentrations of soluble immune inhibitory checkpoint proteins (sICs) in men with and without penile cancer.Materials & Methods: The circulating levels of ten soluble immune inhibitory checkpoint proteins (TIM-3, CD152, HVEM, IDO, LAG-3, BTLA, CD80, PD-1, PD-L1 and PD-L2) were assessed in plasma of 206 men with penile cancer (cases) and 46 men free from penile cancer (controls) using a multiplex Luminex assay. Mean concentrations of sICs were calculated and bootstrap resampling together with Welch's t-tests were used to assess differential expression and distribution of sICs between cases and controls.Results: HVEM was detectable in 87% of the samples. PD-L1 was only detectable in 43.3% and therefore excluded from further analyses. The remaining markers were detectable in all samples. When comparing the mean concentrations of soluble immune inhibitory checkpoint proteins, nine sICs were found in higher concentrations in cases compared to controls, out of which seven reached statistical significance (Table 1).Conclusions: Our study indicates that men with penile cancer have higher concentrations of soluble immune inhibitory checkpoint proteins in plasma compared to penile cancer-free men. Further studies are needed to evaluate their prognostic value}, issn = {0302-2838} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_grenmagnus_2025, title = {Solving Constrained Optimization Problems Using Damped Dynamical Systems}, author = {Ögren, Magnus and Gulliksson, Mårten}, year = {2025}, pages = {32--32}, url = {1987563}, language = {eng}, abstract = {The basis of our approach is a simple second-order damped oscillating dynamical system (a damped mass-spring system with some externalforce). By changing the damping and the force the solution will fast approach a stationary solution with minimal energy.For an optimization problem with constraints we generalize the idea such that the system converges to a stationary solution which is a local minima, most often aiming for the global minima. By using an additional damped system for the constraints, we obtain explicit expressions for the Lagrange parameters. The dynamical system is solved by a symplectic algorithm, that is normally especially tailored for conservative systems.Our method is easy to implement, either with coding or with software for dynamical systems and can be applied to a large number of problems.Numerical experiments show good convergence properties in general, that can be tuned by parameters for the damping and force of the oscillator. In particular, the dynamical constraints make the iterations less sensitive to initial conditions, which do not have to fulfill the constraints.Calculations of eigenvalue problems and ground states of non-linear Schrödinger equations (NLSE) will be presented. We have worked on multi-component nonlinear Schrödinger equations in arbitrary dimensions. Following the experimental developments of quantum droplets of ultra-cold atoms, we are now modeling other forms of nonlinearities. This opens for future research in non-convex optimization, and calculations of higher eigenvalues to non-linear equations.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dahlizabelaa_2025_6, title = {Somewhere in Sweden : An anthology of local historical perspectives on Sweden and the Holocaust}, author = {Dahl, Izabela A.}, year = {2025}, journal = {Historisk Tidskrift}, volume = {145}, number = {1}, url = {1969986}, language = {eng}, publisher = {Svenska Historiska Föreningen}, issn = {0345-469X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_enelojanmagnus_2025, title = {Sons of Honour, Honour of Sons : Expectations of Chastity and Restrictions of Marriage to Identify Boys with Culture of Honour in Sweden}, author = {Enelo, Jan-Magnus and Baianstovu, Rúna Í and Strid, Sofia}, year = {2025}, journal = {NORA: Nordic Journal of Feminist and Gender Research}, volume = {33}, number = {2}, pages = {159--173}, doi = {10.1080/08038740.2024.2439276}, url = {1922919}, language = {eng}, publisher = {Routledge}, keywords = {culture of honour; boys; expectations of chastity; restrictions regarding marriage}, abstract = {In contrast to much previous research on culture of honour, this article focuses on sons and contributes theoretically and empirically to an enhanced understanding of boys. The article explores two indicators of culture of honour based on the boys’ perceptions of their parents’ expectations: 1) restrictions of marriage: not allowed to freely choose future marriage partner and 2) expectations of chastity: expected to remain chaste until marriage. The analysis is based on a quantitative survey of 15-year-olds in metropolitan Sweden. While both indicators are found to identify boys with attitudes and experiences relatable to honour (ancestry from regions with culture of honour, more strongly religious parents with less social and economic resources, experiences of restrictions and violence), they differ from each other. Expectations of chastity identify boys with more religious parents, fewer restrictions, less violence, and associating sex with marriage, while restrictions regarding marriage identify boys with relatively less religious parents, more experiences of restrictions and violence. These differences are discussed as different ways of practicing culture of honour, where expectations of chastity stress age-hierarchical structures relatively more, and restrictions regarding marriage instead stress patriarchal structures more.}, issn = {0803-8740} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_huangqinghui_2025, title = {Source apportionment of organotin pollution in different types of drinking water from megacity communities using multiple receptor models : a case study in Shanghai, China}, author = {Huang, Qinghui and Meng, Ying and Lu, Yang and Zhu, Zhiliang and Qiu, Yanling and Bergman, Åke}, year = {2025}, journal = {Environmental Science: Water Research & Technology}, volume = {11}, number = {6}, pages = {1446--1459}, doi = {10.1039/d4ew00843j}, url = {1944944}, language = {eng}, publisher = {Royal Society of Chemistry}, abstract = {Chemical pollution in drinking water is of great concern. Organotin compounds (OTCs) are a class of persistent toxic substances with the effect of disrupting endocrine function, but potential human health risk due to organotin pollution in drinking water is still less understood. Understanding the occurrence and sources of OTCs in drinking water is crucial. Seventy drinking water samples collected from tap water, water boiling machines and water vending machines in Shanghai were analyzed for seven target OTCs. It is shown that the summed concentrations of target OTCs (& sum;OTCs) were up to 129 ng Sn L-1, with the dominant species being dimethyltin (DMT), dibutyltin (DBT), monobutyltin (MBT) and monomethyltin (MMT). Furthermore, OTC pollution levels varied significantly among drinking water types and water source supply zones, with higher & sum;OTC concentrations observed in tap water and zone A (supplied by an onshore reservoir next to the estuary). To quantify the sources of OTCs in drinking water, we employed two receptor models for comprehensive comparison: principal component analysis-multiple linear regression (PCA-MLR) and positive matrix factorization (PMF). Both models demonstrated excellent fit to the & sum;OTC concentrations, with predicted & sum;OTC values from each model showing a significant correlation (r = 0.9822, p < 0.05). Two main sources of OTCs were identified by using both models: materials used in pipes and drinking fountains and emissions from maritime, agricultural and industrial activities, and the PMF model further distinguished sources associated with degradation. The PMF model emerged as the most appropriate model for organotin source apportionment in drinking water due to its detailed and accurate results. In brief, this study revealed that levels of organotin vary across different water sources and supply zones and identified the main sources of pollution from water sources and water supply processes. This research not only addresses critical knowledge gaps but also provides essential information for informing policy and urban planning, particularly regarding the maintenance of community water purification facilities to ensure drinking water quality in rapidly urbanizing regions.}, issn = {2053-1400} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_puurmia_2025, title = {Spatial and Temporal Patterns of Risk : A Risk Terrain Modeling Approach in Stockholm, Sweden}, author = {Puur, Mia and Doyle, Maria Camacho and Guldaker, Nicklas and Gerell, Manne}, year = {2025}, journal = {European Journal on Criminal Policy and Research}, doi = {10.1007/s10610-025-09625-0}, url = {1965744}, language = {eng}, publisher = {Springer}, keywords = {crime mapping; predictive accuracy index; predictive efficiency index; risk terrain modeling; spatio-temporal; violent crime}, abstract = {Decades of criminological research have highlighted the principle that "place matters" when analysing crime dynamics. While acknowledging this, our study emphasises that place matters at specific times of the day and days of the week. This paper explores spatio-temporal patterns of assaults in public spaces in Stockholm, Sweden, using a time-space modeling approach. By segmenting annual crime registry data into time-specific models (e.g., weekday mornings and weekend nights), sixteen models were created covering two years. Using Risk Terrain Modeling, spatio-temporal cells were analysed with Spearman's Rank Correlations and Predictive Accuracy and Efficiency measures to explore and compare time-specific models to a more generalised annual model. Results suggest that time-specific models perform better in smaller geographical areas compared to a yearly model. However, correlations and GIS mapping show that micro-grid crime hotspots fluctuate within larger hotspots and between years. These findings underscore the need for dynamic hotspot monitoring within crime analysis and for law enforcement to adapt resource allocation at both hotspots and within hot times. By shifting from static annual models to more nuanced temporal models, authorities can enhance crime prevention strategies and optimise interventions at high-risk locations during critical temporal windows.}, issn = {0928-1371} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_wermkewieland_2025, title = {Special education students’ beliefs on inclusion and the role of prior experiences}, author = {Wermke, Wieland and Barow, Thomas and Kuhl, Jan}, year = {2025}, pages = {239--254}, url = {2026759}, language = {eng}, publisher = {Peter Lang Publishing Group}, keywords = {special education; teacher education; special education needs teacher; senco; specialpedagogik; lärarutbildning; speciallärare; specialpedagog} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_murphymark_2025, title = {Special issue introduction : education and the law: critical perspectives on juridification, education governance and social justice}, author = {Murphy, Mark and Bergh, Andreas}, year = {2025}, journal = {Journal of education policy}, volume = {40}, number = {6}, pages = {953--957}, doi = {10.1080/02680939.2025.2564434}, url = {2002851}, language = {eng}, publisher = {Routledge}, issn = {0268-0939}, file = {https://oru.diva-portal.org/smash/get/diva2:2002851/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mirandaip_2025, title = {Spin-lattice couplings in 3d ferromagnets : Analysis from first principles}, author = {Miranda, I. P. and Pankratova, M. and Weissenhofer, M. and Klautau, A. B. and Thonig, Danny and Pereiro, M. and Sjöqvist, E. and Delin, A. and Katsnelson, M. I. and Eriksson, O. and Bergman, A.}, year = {2025}, journal = {Physical Review Materials}, volume = {9}, number = {2}, doi = {10.1103/PhysRevMaterials.9.024409}, url = {1944866}, language = {eng}, publisher = {American Physical Society}, abstract = {Magnetoelasticity plays a crucial role in numerous magnetic phenomena, including magnetocalorics, magnon excitation via acoustic waves, and ultrafast demagnetization, or the Einstein-de Haas effect. Despite a long-standing discussion on anisotropy-mediated magnetoelastic interactions of relativistic origin, the exchangemediated magnetoelastic parameters within an atomistic framework have only recently begun to be investigated. As a result, many of their behaviors and values for real materials remain poorly understood. Therefore, by using a proposed simple modification of the embedded cluster approach that reduces the computational complexity, we critically analyze the properties of exchange-mediated spin-lattice coupling parameters for elemental 3d ferromagnets (bcc Fe, fcc Ni, and fcc Co), comparing methods used for their extraction and relating their realistic values to symmetry considerations and orbitally decomposed contributions. Additionally, we investigate the effects of noncollinearity (spin temperature) and applied pressure on these parameters. For Fe, we find that singlesite rotations, associated with spin temperatures around 100 K, induce significant modifications, particularly in Dzyaloshinskii-Moriya-type couplings; in contrast, such interactions in Co and Ni remain almost configuration independent. Moreover, we demonstrate a notable change in the exchange-mediated magnetoelastic constants for Fe under isotropic contraction. Finally, the conversion between atomistic, quantum-mechanically derived parameters and the phenomenological magnetoelastic theory is discussed, which can be a useful tool towards larger and more realistic dynamics simulations involving coupled subsystems.} } @book{ca0f099bbf2a435cee8f97bef5e8cbaa_krzyzanowskanatalia_2025_1, title = {Spoleczne konstruowanie macierzynstwa w dyskursach polskiej sfery publicznej}, author = {Krzyzanowska, Natalia}, year = {2025}, url = {2039458}, language = {pol}, publisher = {Wydawnictwo Adam Marszalek} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_barroskevin_2025, title = {Sports coaches' perception of health promotion : an exploratory study regarding philosophies, actions, barriers, and strategies}, author = {Barros, Kevin and Lefebvre, Arthur and Geidne, Susanna and Bardid, Farid and Grieco, Spartaco and Johnson, Stacey and Kokko, Sami and Lambe, Barry and Lane, Aoife and Ooms, Linda and Seghers, Jan and Sevdalis, Vassilis and Vuillemin, Anne and Tezier, Benjamin and Van Hoye, Aurélie}, year = {2025}, journal = {Health Promotion International}, volume = {40}, number = {4}, doi = {10.1093/heapro/daaf099}, url = {1983222}, language = {eng}, publisher = {Oxford University Press}, keywords = {health promoting sport coaches; health promotion; sports coaches; strategies}, abstract = {As front-line players in sports clubs, coaches can create a positive context influencing athletes' health decisions and behaviours. However, coaches rarely engage in health promotion (HP) practices due to various obstacles. Coaching philosophy, encompassing beliefs, principles, and values, significantly influences coaches' practices. However, its impact on HP remains unexplored, are the main factor influencing coaches' practices, has not yet been studied in regard to HP. The aim of this study was to explore coaches' perceptions of what they define as health in relation to their coaching philosophies, actions and strategies they undertake in relation to HP, as well as alignment or discrepancies between these three elements. An exploratory mixed-method survey design (QUAL=>quan) was used in this study. A sample of 299 sports coaches in Europe completed an online survey, including closed ended questions on their influence on sports participants health behaviours, barriers for HP and open-ended questions on coaching philosophies and associated health benefits, keywords linked to health, and strategies for HP. Qualitative and quantitative data were analysed using inductive thematic analysis and multivariate statistics respectively. While coaches define health mainly through keywords related to physical health (e.g. 'hydration', 'recovery'), their perceived coaching philosophies were focused around nine themes, related to social and mental health, predominantly using participant management and communication as implementation strategies. Furthermore, they identified lack of time, knowledge and human resources as the main barriers to pay attention to HP. The present findings highlight a gap between how coaches define health, what they consider they can influence and how they promote health. Further work is needed to explore the paradox between coaches' definition of health and self-reported actions focusing mostly on social and mental health mostly.}, issn = {0957-4824} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_barkerruchtinatalie_2025_4, title = {Sports Coaching Education and Alternative Pedagogies : Approaches in Higher Education}, author = {Barker-Ruchti, Natalie and Purdy, Laura G.}, year = {2025}, url = {1953080}, language = {eng}, publisher = {Routledge}, abstract = {Sports Coaching Education: Applying Innovative Pedagogies theorises alternative pedagogies and presents examples of what such teaching looks like in sports coaching higher education. To do this, this new volume outlines the teaching goals of higher education coach education, summarises the limitations of this education that research has demonstrated, and presents alternative pedagogy as a way forward. The book then turns to showcasing work by an international selection of authors practicing alternative pedagogies that focus on a range of topical issues relevant to sports coaching such as; ethics; power; safeguarding/abuse; sustainability gender/sexuality; race/ethnicity; pain/injury, the authors of each of the international chapters outline the alternative pedagogical approach they employ in their teaching and present exemplary teaching materials that can be used by educators.Alternative or non-traditional pedagogies are strategies of delivery that are becoming more popular in undergraduate and postgraduate coach education, Sports Coaching Education: Applying Innovative Pedagogies raises attention to contemporary issues in sports coaching and alternative pedagogies of delivery for university coach education students.Using alternative pedagogies, the book presents coach education teaching materials on a range of topical issues that higher education scholars can implement in their teaching and will be key reading for academics, researchers and students in the areas of sport coaching, sport education and the related disciplines.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_roerlouise_2025, title = {Spread of the FAR-MRSA clone, a fusidic acid-and meticillin-resistant Staphylococcus aureus ST121, Europe, 2014 to 2024}, author = {Roer, Louise and Yin, Nicolas and Denis, Olivier and Vendrik, Karuna E. W. and Zwittink, Romy D. and Notermans, Daan W. and Perrin, Monique and Khonyongwao, Kirstin and Tristan, Anne and Youenou, Benjamin and Layer-Nicolaou, Franziska and Werner, Guido and Enger, Hege and Eikrem, Emily Charlotte Henry and Darenberg, Jessica and Makitalo, Barbro and Paulsson, Magnus and Björkman, Jonas and Fang, Hong and Hallbäck, Erika Tang and Sundqvist, Martin and Lindholm, Laura and Moganeradj, Kartyk and García-Cobos, Silvia and Cañada-García, Javier E. and Holzknecht, Barbara Juliane and Eriksen, Helle Brander and Hoppe, Morten and Bartels, Mette Damkjaer and Castruita, Jose Alfredo Samaniego and Urth, Tinna Ravnholt and Larsen, Anders Rhod and Petersen, Andreas}, year = {2025}, journal = {Eurosurveillance}, volume = {30}, number = {28}, doi = {10.2807/1560-7917.ES.2025.30.28.2500452}, url = {1988939}, language = {eng}, publisher = {European Centre for Disease Prevention and Control}, abstract = {We describe the genetic characteristics of a fusidic acid-and meticillin-resistant Staphylococcus aureus (MRSA) clone widespread in Europe, based on whole genome sequences from 317 isolates. The clone is causing impetigo and other skin and soft tissue infections, primarily in young children. Comparison with publicly available S. aureus ST121 sequences showed that the clone is clearly distinct from previously described ST121 clones. European and other international readers should be aware of the emergence of this community-acquired MRSA clone.}, issn = {1025-496X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_josefssonandreas_2025, title = {SPRINTR-Swedish PRostate cancer Initiative for Novel Treatment Regimens Biomarker driven precision medicine}, author = {Josefsson, Andreas and Bjartell, Anders and Stranne, Johan and Akre, Olof and Holmbom, Martin and Davidsson, Sabina and Wikström, Pernilla and Lundeberg, Joakim and Sjostrom, Martin and Wählby, Carolina and Ahlberg, Mats and Ugge, Henrik and Stenman, Caroline and Riklund, Katrine and Nordström, Tobias and Strandberg, Sara and Trägårdh, Elin and Fransson, Per and Landström, Marene and Thellenberg, Camilla and Welén, Karin}, year = {2025}, journal = {Scandinavian journal of urology}, volume = {60}, number = {Suppl. 223}, pages = {11--12}, url = {1998959}, language = {eng}, publisher = {Medical Journals Sweden AB/MJS Publishing}, abstract = {Introduction: Approximately half of all prostate cancer-related deaths occur in men with non-metastatic disease at the time of diagnosis, a group that has a relatively good chance of a cure. Therefore, improving treatment for high-risk prostate cancer patients at this stage has the potential to save many lives. The aim of SPRINTR is to identify biomarkers that can help select patients for whom current treatment is insufficient and to evaluate matched therapies in a platform study for clinical trials. A key challenge for clinical drug trials in Sweden is the combination of a relatively small population and inefficient recruitment processes, coupled with time-consuming administrative procedures. In the initial phase of SPRINTR, the SPRINTR-real initiative is being established to integrate study invitations and molecular tissue characterization into the diagnostic workflow for all men undergoing biopsy due to sus-pected prostate cancer.Method: SPRINTR-real form a novel concept of a national study framework for the inclusion of all men with prostate cancer, linked to a national platform, automated follow-up via national registries, feeding into a study database. Participants consent to: (1) the use of molecular data from their tissue samples in biomarker studies, (2) the use of their personal identification numbers for health-related data retrieval from the National Board of Health and Welfare and Statistics Sweden, and (3) potential matching and invitations to future studies based on the collected data.Results: For the high-risk patient group, the workflow will include RNA expression profiling of tumor-containing biopsies, analysis of cancer-related mutations (GMS560), and AI-based image analysis. These data can be put together to create an optimized biomarker panel, or “classifiers,” which will serve as tools in biomarker-guided randomization for upcoming studies within the SPRINTR-trial platform.Conclusion: The overall objective of this project is to increase survival and quality of life for PC patients in Sweden (www.sprintr.se).}, issn = {2168-1805} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_olssonsylvia_2025, title = {Staff perspectives on independence and collaborative practices in the IRIS intervention : an evaluation in Swedish LSS residential homes}, author = {Olsson, Sylvia and Loeb, Carina and Dag, Munir}, year = {2025}, journal = {Frontiers in Rehabilitation Sciences}, volume = {6}, doi = {10.3389/fresc.2025.1571233}, url = {1957871}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {intellectual disability; disability; interventions; self-efficacy; inclusion}, abstract = {Background and purpose: Intensive Rehabilitation Coordination (IRIS), is an intensive, health-promoting habilitative intervention designed to prevent, reduce, and compensate for individuals’ support needs while enhancing their independence. The purpose of this study is to explore staff experiences with the IRIS intervention in a municipality’s LSS1 residential homes, with a focus on how independence is defined and operationalized and the resulting impact on service delivery.Methods: A qualitative study was conducted in which staff from various LSS residential homes were interviewed. The interviews were structured to examine differences in the interpretation of independence, the strategies used to support service users, and the collaborative nature of the intervention. Participants were asked to describe their approaches to encouraging or supporting independence in daily tasks and their interactions with quality coordinators.Results: The analysis revealed a lack of a shared definition of independence among staff, leading to varied approaches in supporting service users. Some staff members actively promoted independence by encouraging service users to perform everyday tasks on their own, while others performed these tasks for the service users due to practical considerations such as convenience and efficiency. Despite these variations, staff reported that service users still have the opportunity to make their own decisions regarding daily activities. Overall, the IRIS intervention was viewed positively, with its collaborative implementation cited as a key strength.Discussion: The findings suggest that the absence of a unified conceptualization of independence can lead to inconsistent practices in LSS residential homes, potentially affecting the effectiveness of the intervention. The collaborative approach of IRIS, which fosters joint efforts among municipal professionals, appears to be instrumental in understanding and addressing service users’ needs. Future research should focus on establishing a more standardized definition of independence to improve intervention consistency and outcomes for service users.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_leydenandrew_2025, title = {Standards and the EU AI act : legitimacy, state of play, and future challenges}, author = {Leyden, Andrew}, year = {2025}, journal = {Information & communications technology law}, doi = {10.1080/13600834.2025.2570966}, url = {2008026}, language = {eng}, publisher = {Routledge}, keywords = {ai; ai act; eu law; standards; cenelec; cen/cenelec; iso; iec}, abstract = {The EU's Artificial Intelligence Act ('AI Act') delegates key regulatory functions to harmonised socio-technical standards developed by private bodies under the New Legislative Framework ('NLF'). While this promises efficiency and flexibility, it raises legitimacy concerns - especially given the AI Act's fundamental rights objectives. This article critically examines the legal basis and governance structure of the standardisation process, focusing on the roles of CEN, CENELEC, and international cooperation with ISO/IEC. It assesses the inclusiveness, transparency, and accountability of these processes, highlighting risks of over-delegation in areas touching constitutional values. Applying a framework of input, output, and throughput legitimacy, it identifies procedural gaps and analyses the implications of the CJEU's 2024 landmark Public.Resource.Org judgment on access to standards. It concludes with proposals aimed at improving the legal and normative legitimacy of future standardisation in AI, arguing that AI governance depends not only on technical quality but also on democratic accountability and rights-based alignment.}, issn = {1360-0834} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sderquistbo_2025, title = {Staphylococcus aureus From Prosthetic Joint Infections and Blood Cultures Display the Same Genetic Background}, author = {Söderquist, Bo and Wildeman, Peter and Stegger, Marc and Stenmark, Bianca}, year = {2025}, journal = {Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)}, volume = {133}, number = {7}, doi = {10.1111/apm.70038}, url = {1982340}, language = {eng}, publisher = {Munksgaard Forlag}, keywords = {staphylococcus aureus; hema‐togenous infections; prosthetic joint infections; whole‐genome sequencing}, abstract = {Hematogenous prosthetic joint infections (PJIs) are primarily associated with Staphylococcus aureus, and there is a 30%-40% risk of contracting a hematogenous PJI following an S. aureus bacteremia. The aim of this study was to investigate whether identical strains of S. aureus were present in each patient from a cohort with both bacteremia and PJI and to explore the genomic differences between paired isolates obtained from blood cultures and tissue biopsies. All patients with a PJI and a temporally concomitant bacteremia due to S. aureus from 2005 to 2020 were included. Paired isolates of S. aureus from tissue biopsies and blood cultures were subjected to whole-genome sequencing. Twenty-four episodes of PJI were identified in 23 patients. All pairwise isolates from individual patients belonged to the same multilocus sequence type, clonal complex, and core genome multilocus sequence typing (cgMLST) complex type. The median number of single nucleotide polymorphisms (SNPs) in the conserved core genomes between the pairwise isolates was 3. In conclusion, identical cgMLST complex types and low levels of SNP differences between paired isolates of S. aureus from blood cultures and tissue biopsies suggest hematogenous seeding in all cases of PJI in this cohort.}, issn = {0903-4641} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wernjohan_2025, title = {Staphylococcus aureus vertebral osteomyelitis : a single-centre retrospective cohort study with focus on oral flucloxacillin follow-up}, author = {Wern, Johan and Söderquist, Bo and Tevell, Staffan}, year = {2025}, journal = {European Journal of Clinical Microbiology and Infectious Diseases}, volume = {44}, number = {9}, pages = {2077--2084}, doi = {10.1007/s10096-025-05176-8}, url = {1965711}, language = {eng}, publisher = {Springer}, keywords = {vertebral osteomyelitis; s. aureus bacteraemia; flucloxacillin; cloxacillin; beta-lactam antibiotics}, abstract = {Background: International guidelines for Staphylococcus aureus vertebral osteomyelitis recommend 6 weeks of treatment, including oral follow-up using antibiotics with high bioavailability such as a fluoroquinolone/rifampicin combination. Oral flucloxacillin is not recommended due to low bioavailability and scarce evidence. However, flucloxacillin as oral follow-up treatment is common practice in Sweden based on favourable clinical experience, good tolerability, few interactions, and low ecological impact. Our aim was to review a single-centre experience of S. aureus vertebral osteomyelitis, with focus on flucloxacillin treatment.Methods: A single-centre retrospective cohort of patients with Staphylococcus aureus vertebral osteomyelitis (n = 40) was identified between 2010 and 2016. Patients were further stratified by antibiotic treatment strategy with focus on oral flucloxacillin therapy (n = 24). Primary outcomes were relapse or death within 12 months of treatment initiation, and antibiotic-related adverse effects during treatment.Results: Methicillin-susceptible S. aureus (MSSA) caused 38 of the infections (95%), and five patients (13%) died, all in-hospital. Flucloxacillin was used for at least 75% of the oral treatment duration in 24 patients (60%). Median antibiotic treatment duration among these patients was 125.5 days (IQR 95-182), 109 days (IQR 76-149) of which comprised oral antibiotics. There were two relapses and two deaths among the patients treated predominantly with flucloxacillin, resulting in a composite clinical cure rate of 83% (20 of 24).Conclusions: Prolonged oral flucloxacillin administration could be a potential treatment option for MSSA vertebral osteomyelitis. A prospective study of optimal treatment duration and dosing strategies for flucloxacillin in vertebral osteomyelitis is warranted.}, issn = {0934-9723} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ugrinovivukain_2025, title = {Starch-Gelatin-Based Scaffolds for Cartilage Defect Repair : An in vitro Study Supporting Its Potential Clinical Use}, author = {Ugrinović, Vukašin and Veljović, Đorđe and Matić, Tamara and Stevanović, Julijana and Wretenberg, Per and Ivarsson, Mikael and Andjelkov, Nenad}, year = {2025}, journal = {Cartilage}, doi = {10.1177/19476035251407298}, url = {2024422}, language = {eng}, publisher = {Sage Publications}, keywords = {chondrogenesis; matrix-assisted chondrocyte implantation; scaffolds; starch-gelatin}, abstract = {Objective: The aim was to investigate starch-gelatin hydrogels as scaffolds for chondrogenesis and compare these with other materials currently in use regarding cell retention and growth.Methods: Two variants of starch-gelatin-scaffolds and one chitosan-based scaffold were fabricated by casting and freeze-drying. The resulting materials were analyzed with respect to physicochemical and mechanical properties, cut to size, and seeded with human articular chondrocytes. Cell retention and proliferation were evaluated at 1, 14, and 42 days of culturing. Extracellular matrix production was analyzed by histo- and immunohistochemistry. Comparisons were made with that of commercially available hyaluronan- (Hyalofast®) and collagen-based (ChondroGide®) scaffolds, and synthesized chitosan hydrogels.Results: The starch-gelatin materials exhibited highly porous structures stabilized by hydrogen bonding, with swelling behavior similar to native cartilage and favorable mechanical handling properties. Despite differences in initial cell retention, all materials except chitosan supported robust cell growth, reaching similar levels after 14 days. No significant changes were observed between 14 and 42 days with the exception of Hyalofast® showing decreased cell number. Chitosan-supported cell growth was more linear over the culture period, but resulted in only half the cell number by day 42 compared with the other materials. Without cells, Hyalofast and one variant of the starch/gelatin hydrogel degraded before day 42. starch/gelatin scaffolds showed collagen I, II, and aggrecan deposition.Conclusion: Starch-gelatin scaffolds displayed favorable mechanical properties, supported cell growth comparable to commercial scaffolds, and promoted deposition of cartilage-specific extracellular matrix, highlighting their chondrogenic potential.}, issn = {1947-6035} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fresnaisdavid_2025, title = {Statin treatment for cerebral small vessel disease : A systematic review and meta-analysis of randomized controlled trials}, author = {Fresnais, David and Fure, Brynjar}, year = {2025}, journal = {Cerebral Circulation - Cognition & Behavior (CCCB)}, volume = {9}, doi = {10.1016/j.cccb.2025.100389}, url = {1986222}, language = {eng}, publisher = {Elsevier}, keywords = {dementia; cognitive impairment; statins; cerebral small vessel disease; meta-analysis}, abstract = {Background: Cerebral small vessel disease (CSVD) is a chronic, progressive disorder that affects small blood vessels in the brain's white matter. This white matter damage appears on brain imaging as white matter hyperintensities (WMH). Although CSVD is often asymptomatic, it causes one fifth of strokes and nearly half of all vascular dementia cases, highlighting its clinical importance. Statins, widely used to lower lipid levels, are effective for reducing cardiovascular mortality in high-risk groups and are recommended for patients with myocardial infarction and ischemic stroke.Aim: This systematic review and meta-analysis of randomized controlled trials aimed to evaluate the impact of statin therapy on CSVD.Method: A literature search was performed in PubMed, Embase, the Cochrane Library and Epistemonikos resulting in the full-text review of 86 articles, of which two were used for the meta-analysis.Results: A non-significant trend towards lower WMH volume in milliliters was observed in the statin group compared to controls, mean difference (MD) =-4.44 (95 % CI-10.19-1.31).Conclusion: There is limited evidence available for the use of stain-treatment for CSVD, and further research is needed as well as studies on the clinical and person-centered benefits of statins on cognition and functional level in persons with CSVD.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_khalilihamed_2025, title = {Statin Use is Associated with a Less Severe Disease Course In Inflammatory Bowel Disease : A Nationwide Cohort Study 2006-2020}, author = {Khalili, Hamed and Forss, Anders and Söderling, Jonas and Bröms, Gabriella and Eriksson, Carl and Sun, Jiangwei and Ludvigsson, Jonas F. and Olén, Ola}, year = {2025}, journal = {Inflammatory Bowel Diseases}, volume = {31}, number = {10}, pages = {2787--2797}, doi = {10.1093/ibd/izaf077}, url = {1954874}, language = {eng}, publisher = {Oxford University Press}, keywords = {crohn’s disease; inflammatory bowel disease; statins; ulcerative colitis}, abstract = {BACKGROUND: Statins reduce the risk of inflammatory bowel disease (IBD), however their effect on IBD disease progression is largely unknown.METHODS: We linked Swedish healthcare registers and performed a nationwide cohort study (2006-2020) of 19 788 adults (≥18 years) with ulcerative colitis (UC) and 12 582 with Crohn's disease (CD). Of these, 1733 with UC and 962 with CD were identified as incident statin users after UC or CD diagnosis. After 1:1 propensity score matching, we compared statin users with non-users to estimate the risk of IBD-related surgery, hospitalizations, and disease flares expressed as incidence rates (IRs) and multivariable-adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs). For outcomes with statistically significant estimates, we calculated the numbers needed to treat (NNT).RESULTS: During a median follow-up of 3.4 years we observed a reduced risk of IBD-related surgery in statin users (UC, IR: 3.4 [95%CI: 2.1-4.8] per 1000 person-years; CD, IR: 9.2 [6.2-12.2]) compared with non-users in UC (IR: 6.3 [4.2-8.5]; aHR: 0.55 [0.31-0.97]) and CD (IR: 15.4 [11.0-19.7]; aHR: 0.54 [0.33-0.88]). The NNT to avoid one IBD-related surgical event per year of statin treatment were 345 (UC) and 161 (CD). For statin users, the risks of hospitalizations (IR: 17.0 [13.9-20.2]; aHR: 0.68 [0.51-0.91]) and disease flares (IR: 207.4 [193.2-221.6]; aHR: 0.86 [0.77-0.97]) were reduced in UC, but not in CD (IR: 20.3 [15.8-24.9]; aHR: 0.78 [0.56-1.09] and IR: 245.5 [223.9-267.1]; aHR: 1.02 [0.88-1.19]). In UC, NNT for hospitalizations and disease flares were 145 and 15.CONCLUSIONS: Statins were associated with a reduced risk of IBD-related surgery, hospitalizations, and disease flares in patients with UC, and with a reduced risk of IBD-related surgery in patients with CD.}, issn = {1078-0998} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lodefalkmagnus_2025_2, title = {Stayin' alive : export credit guarantees and export survival}, author = {Lodefalk, Magnus and Tang, Aili and Yu, Miaojie}, year = {2025}, journal = {Applied Economics Letters}, doi = {10.1080/13504851.2025.2549506}, url = {1995032}, language = {eng}, publisher = {Routledge}, keywords = {exports; survival; export credit guarantees; firms}, abstract = {We use survival analysis to analyse the impact of export credit guarantees on firms' export duration using granular Swedish panel data at the firm-country and firm-country-product levels. The estimation results show that firms' export survival substantially increases with guarantees, at both levels. The associations are particularly strong for smaller firms and contracts as well as in trade with riskier markets. The findings have implications for policies to promote long-run export growth.}, issn = {1350-4851} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_elanderingemar_2025, title = {Stig Montin tur och retur : Från decentralisering, privatisering och statlig styrning till hybridpolitik i den perfekta stormens tid}, author = {Elander, Ingemar}, year = {2025}, pages = {53--66}, url = {1967888}, language = {swe}, publisher = {Södertörns högskola} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_larssonkarl_2025, title = {Stochastic modeling with time-inhomogeneous Jacobi diffusions : applications to bounded and seasonal environmental processes}, author = {Larsson, Karl}, year = {2025}, journal = {Stochastic environmental research and risk assessment (Print)}, volume = {39}, number = {1}, pages = {41--54}, doi = {10.1007/s00477-024-02849-2}, url = {1929612}, language = {eng}, publisher = {Springer}, keywords = {stochastic differential equations; jacobi process; diffusion; seasonality; environmental data; relative humidity}, abstract = {In this paper we explore stochastic modeling of bounded processes in continuous time using time-inhomogeneous Jacobi diffusions. We present some basic general results and introduce a subclass of models with seasonal time variation. In the seasonal models we derive the conditional mean and variance in closed form and propose a strategy for estimation based on quasi maximum likelihood. An empirical application is carried out to daily time series data on relative humidity. Simulation methods are used to investigate properties of the resulting parameter estimators. The results show that the proposed seasonal Jacobi model gives a very satisfactory fit to data and that the estimation procedure works well.}, issn = {1436-3240} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_websternatashaa_2025_2, title = {Storytelling as connectivity : expanding the digital geographies of the gig economy}, author = {Webster, Natasha A.}, year = {2025}, journal = {Social & Cultural Geography}, volume = {26}, number = {1}, pages = {1--19}, doi = {10.1080/14649365.2024.2367417}, url = {1880532}, language = {eng}, publisher = {Routledge}, keywords = {connective digital practices; gig economy; work; masculinities; migration; storytelling}, abstract = {The last decade has seen unprecedented changes in working forms, not the least through technological innovation while leisure time is equally reshaped by platforms. Although relatively new, the gig economy – temporary work mediated through platforms – is increasingly an important form of employment globally and consequently, the gig economy is represented in popular culture. Popular culture is part of social-technical-spatial relations making these important spaces in digital geographies. However, digital content, for example from streaming programs, is often not considered in labour geography studies. By conducting ethnographic content analysis and doodling ‘think-with’ work on Beforeigners, a piece of speculative fiction from Norway, I explore how storytelling conjoins parallel digital practices. I show storytelling as a kind of softening of ground narrating technological-spatial relations and demonstrates how, from this Nordic example, storytelling is part of the continuative geographical ordering of work forms in digital spaces and places. Exploring other sites of digital spaces highlights the ways digital geography is multi-layered, inter-relational and gradient, and demonstrates the need to go beyond established sites of inquiry to understand the gig economy as a social-technological-spatial relation.}, issn = {1464-9365}, file = {https://oru.diva-portal.org/smash/get/diva2:1880532/FULLTEXT01.pdf} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_grenmalin_2025, title = {Strategic Communication and Preparedness : Discursive Legitimation Practices in Swedish Total Defence Organizations}, author = {Ågren, Malin}, year = {2025}, url = {1947456}, language = {eng}, publisher = {Örebro University}, keywords = {strategic communication; public sector organizations; preparedness; discursive legitimation; critical discourse analysis}, abstract = {The aim of this compilation thesis is to investigate how a group of Swedish public sector organizations with key roles in the country’s total defence system discursively legitimate preparedness issues through strategic communication, at a time when the question of preparedness is receiving increasing priority in Swedish society. Using a critical discourse methodology in three empirical studies, the thesis shows how communication about preparedness plays an important role in how three types of organizations seek to gain legitimacy for themselves and for their operations, as well as for preparedness as a societal phenomenon.The findings show that all three organizations, the Swedish Armed Forces (SAF) [Försvarsmakten], municipalities, and the Swedish Civil Contingencies Agency (MSB) [Myndigheten för samhällsskydd och beredskap], rely heavily on a normalizing message in their communication, as well as on the legitimation strategies of moralization and rationalization. The findings furthermore pinpoint how the role of the public sector organizations is largely backgrounded in this communication, and the individual citizen’s responsibility for preparedness is highlighted instead.Due to the strategic importance of this kind of communication in these organizations’ legitimation process, the thesis concludes that it should be regarded here as a particular form of strategic communication, called “preparedness communication”. Through its focus on the discursive micro-levels, the thesis shows how such communication is performed in practice, and how it is an integral part of the public sector’s overarching strategic communication, in times of both stability and uncertainty.}, file = {https://oru.diva-portal.org/smash/get/diva2:1947456/FULLTEXT01.pdf;https://oru.diva-portal.org/smash/get/diva2:1947456/FULLTEXT04.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_websternatashaa_2025_3, title = {Strategic silences for normative work : Inclusions and exclusions of migrant labour in policy foregrounding of the Swedish gig economy}, author = {Webster, Natasha A. and Zhang, Qian}, year = {2025}, journal = {Geoforum}, volume = {158}, doi = {10.1016/j.geoforum.2024.104157}, url = {1917315}, language = {eng}, publisher = {Elsevier}, keywords = {gig economy; work; migration; welfare state; silence; critical content analysis; swot; sweden}, abstract = {Migrants constitute a sizable portion of vulnerable workers in digitally-mediated work, particularly in the gig economy. They face wide-scale labour exploitation as well as exclusions and further marginalization from existing labour markets and welfare systems. Policy intervention is a focal point of debate in the expanding gig economy literature. In Nordic countries, it is often assumed the welfare state will regulate the gig economy, but due to ambiguous understandings of what the gig economy is, debates are focused on topics such as taxation, often downplaying complexities. This study aims to explore how strategic silences towards migration underpin policy narratives relating to the foregrounding of gig economy in welfare contexts, specifically Sweden. Our approach highlights silence as an agentic and strategic process. Based on twenty-three selected Swedish Government Official Reports (SOU series) issued between 2016 and 2022, we first mapped the main themes regarding the gig economy in the Swedish policy arena. We show the Swedish state is shifting to recognize migrants and the gig/platform economy, but the role of structural inequalities remains ambiguous. We further critically analyzed contents of ten reports and show silence is strategic in two ways: first maintaining normative work forms as the key interest of the state and second, positioning precarious migrant labour as a sphere of exclusion. This study provides new perspectives and insights into the governance of the gig economy by highlighting the role of strategic production of silences regarding structural inequalities and the tensions within welfare-labour relations.}, issn = {0016-7185} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_mattssonstig_2025_1, title = {Strategies for Glycemic Control in Type 1 Diabetes Before, During and After Prolonged Exercise}, author = {Mattsson, Stig}, year = {2025}, url = {1996463}, language = {eng}, publisher = {Örebro University}, keywords = {carbohydrates; continuous glucose monitoring; diabetes self-management; diabetes sports camps; education; exercise; hypoglycemia; insulin; type 1 diabetes}, abstract = {Background: Physical exercise (PE) represents a challenge in achieving stable glycemic control in individuals with type 1 diabetes (T1D), especially during prolonged PE. Achieving euglycemia requires careful adjustments of carbohydrate (CHO) intake and insulin doses before, during, and after PE, by proactive use of continuous glucose monitoring (CGM).Aim: This thesis evaluated strategies for achieving glucose control in T1D before, during, and after prolonged PE, focusing on CHO intake, insulin adjustments assisted by CGM, and education intended to improve self-management.Methods: Four studies were conducted: (1) High CHO intake with insulin adjustments during prolonged PE; (2) CHO loading, tailored pre-race insulin dose, and high CHO intake during PE; (3) CHO replenishment after evening exercise on nocturnal glucose regulation in healthy individuals; and (4) impact of a diabetes sports camp for adults integrating education and exercise and long-term self-management.Results: Before PE: CHO loading with basal insulin adjustment maintained stable glycemia. Tailored pre-race insulin supported euglycemia. During PE: High CHO intake (75–100 g/h) with individualized insulin strategies enabled stable glucose levels. After PE: The timing of CHO intake did not affect nocturnal glucose levels when daily energy and CHO needs were met. Self-management: The diabetes sports camp was associated with improvements in perceived diabetes self-management skills.Conclusion: Glycemic stability in T1D before, during, and after prolonged PE is achievable through individualized CHO and insulin strategies, supported by CGM and structured education.}, file = {https://oru.diva-portal.org/smash/get/diva2:1996463/FULLTEXT01.pdf} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_tunstrmmoa_2025, title = {Strategisk planering i regional kontext : Centrala begrepp och narrativ i svensk policy under 2010- och 20-talen}, author = {Tunström, Moa and Andersson, Ida}, year = {2025}, doi = {10.59217/fogo5518}, url = {1982273}, language = {swe}, publisher = {Karlstads universitet, Centrum för forskning om hållbar samhällsförändring}, file = {https://oru.diva-portal.org/smash/get/diva2:1982273/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrndalludvigd_2025, title = {Stress Resilience and Risk of Psychiatric Disorders After Childhood Bereavement}, author = {Bjørndal, Ludvig D. and Chen, Yufeng and Lu, Donghao and Brikell, Isabell and Kuja-Halkola, Ralf and D'Onofrio, Brian M. and Lundin, Andreas H. and Lichtenstein, Paul and Larsson, Henrik and Daníelsdóttir, Hilda Björk and Fall, Katja and Valdimarsdóttir, Unnur A. and Fang, Fang}, year = {2025}, journal = {JAMA Network Open}, volume = {8}, number = {7}, doi = {10.1001/jamanetworkopen.2025.19706}, url = {1983220}, language = {eng}, publisher = {American Medical Association (AMA)}, abstract = {IMPORTANCE: Childhood bereavement increases the risk of common psychiatric disorders later in life. However, the role of stress resilience in this association remains underexplored.OBJECTIVE: To assess whether stress resilience mediates the association between childhood bereavement and psychiatric disorder risk in adulthood.DESIGN, SETTING, AND PARTICIPANTS: Three matched cohort studies were performed using data recorded in the Swedish Military Conscription Register. Individuals with childhood loss of either a parent or a sibling (19 162 participants), a parent (16 247 participants), or a sibling (3023 participants) due to death from 1987 to 2020, together with 10 unexposed individuals per exposed individual, were matched on sex, birth year, and county of birth. All participants had available stress resilience measure at conscription. Data were analyzed from February to December 2024.EXPOSURES: Childhood bereavement was ascertained from the Swedish Multi-Generation and Causes of Death Registers.MAIN OUTCOMES AND MEASURES: Incident diagnosis of depression, anxiety, substance use disorder, and stress-related disorder was ascertained from the Swedish Patient Register. Cox models were used to estimate the association between childhood bereavement and risk of postconscription psychiatric disorders after multivariable adjustment. Causal mediation analysis was conducted to examine if stress resilience measured at conscription mediated this association.RESULTS: Among 1 733 085 conscripted individuals (median [IQR] age at conscription 18.2 [18.0-18.5] years; 1 707 960 [98.5%] male), the median (IQR) age of individuals exposed to loss of either a parent or a sibling, parent, or sibling was 13.4 (9.6-15.8), 13.7 (10.4-15.9), and 10.7 (5.5-14.9) years, respectively. The crude incidence rate of any psychiatric disorder was 7.9, 8.1, and 6.6 per 1000 person-years among the 3 groups (5.3, 5.8, and 5.5 per 1000 person-years among the respective unexposed groups). A positive association was noted for loss of either a parent or a sibling (HRs ranged from 1.13; 95% CI, 1.06-1.20 for anxiety to 1.31; 95% CI, 1.23-1.40 for substance abuse disorder) and loss of a parent (HRs ranged from 1.10; 95% CI, 1.01-1.20 for stress-related disorders to 1.19; 95% CI, 1.12-1.27 for depression). For loss of a sibling, the statistically significant associations were for any common psychiatric disorder (HR, 1.12; 95% CI, 1.00-1.25) and stress-related disorders (1.27; 95% CI, 1.04-1.55). Stress resilience partially mediated the associations (proportions for loss of either a parent or a sibling ranged from 10.6%-19.4%, for a parent ranged from 15.6%-21.7%, and for a sibling ranged from 6.2% for stress-related disorders to 18.4% for any common psychiatric disorder).CONCLUSIONS AND RELEVANCE: In this cohort study of a nationwide Swedish sample, altered stress resilience was found to be one mechanism through which childhood bereavement is associated with risk of psychiatric disorders later in life.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dasilvagustavoassis_2025, title = {Stress‐Constrained Topology Optimization With the Augmented Lagrangian Method : A Comparative Study of Subproblem Solvers}, author = {Da Silva, Gustavo Assis and Emmendoerfer, Hélio}, year = {2025}, journal = {International Journal for Numerical Methods in Engineering}, volume = {126}, number = {12}, doi = {10.1002/nme.70066}, url = {1973094}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {augmented lagrangian method; comparative study; high-resolution analysis; optimization solvers; stress constraints; topology optimization}, abstract = {Incorporating stress constraints in topology optimization is a challenging task due to the large number of constraints in the formulation. One effective strategy to address this challenge is the augmented Lagrangian (AL) method, which transforms the original stress-constrained problem into a sequence of subproblems with only bound constraints. The effectiveness of the AL method heavily depends on the optimization method used to solve these subproblems. This work performs a comparative study of six optimization solvers: The method of moving asymptotes (MMA), the steepest descent method with move limits (SDM), the spectral projected gradient (SPG), and the limited-memory BFGS with bound constraints (L-BFGS-B), along with two proposed adaptations, steepest descent method with move limits—Barzilai–Borwein (SDMBB) and spectral projected gradient with move limits (SPGM). These methods are evaluated in the context of the volume minimization problem with local stress constraints. The solutions are compared in terms of performance, defined as the final volume fraction, and efficiency, measured by the number of state and adjoint analyses required. A mesh dependence study is conducted to assess the robustness of each method across different mesh sizes, including high-resolution cases with approximately 1.8 million elements. SDMBB exhibits the highest efficiency, while SPGM achieves the best performance, followed by SDM. The MMA, SPG, and L-BFGS-B show limitations in high-resolution problems or fail to meet specific stopping criteria. The results demonstrate that the choice of the optimization solver significantly affects the efficiency of the AL method, as well as the performance and mesh dependence of the solutions. Furthermore, this study identifies the most promising methods for solving large-scale stress-constrained problems.}, issn = {0029-5981} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sultanulrika_2025_1, title = {Stronger Together : Interdisciplinary Teaching in Action}, author = {Sultan, Ulrika}, year = {2025}, journal = {Pedagogical Dialogue}, volume = {51}, number = {1}, url = {1946148}, language = {eng}, publisher = {PE “Center of Excellence” NIS}, keywords = {interdisciplinary teaching; teacher training; collaborative learning; authentic learning; subject didactics}, abstract = {Interdisciplinary teaching is transforming teacher education, equipping future educators with the skills to connect knowledge across subjects and develop dynamic, real-world teaching strategies. In today’s complex learning environments, collaboration across disciplines is no longer optional - it is essential. This article shares how an interdisciplinary teaching team in a higher education teacher training programme navigates this challenge. Involving one art educator, three science educators, and one technology education educator, the team worked together to design, implement, and evaluate interdisciplinary coursework based on cognitive learning theories and authentic learning principles. The described case goes beyond just integrating subjects - it highlights the human side of interdisciplinary teamwork. Trust, clear communication, and shared responsibility are key to making progress. Strong team relationships help educators combine their expertise in ways that improve both teaching and student engagement. The text also explains how interdisciplinary lessons are planned and carried out, showing how strategies like concept mapping, backward design, and co-teaching create a more connected and meaningful learning experience for students. For teachers, interdisciplinary teamwork is more than a strategy - it is a professional growth opportunity. By embracing collaboration, educators become more adaptable, improve their instructional flexibility, and enhance their ability to teach across multiple disciplines. Teacher training programmes that prioritise interdisciplinary teamwork not only improve classroom teaching but also prepare educators to tackle the evolving challenges of modern education. This study underscores the need for structured teamwork in higher education and shows how interdisciplinary collaboration strengthens the preparation of future educators for the demands of contemporary classrooms.}, issn = {2308-7668} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_andrndaniela_2025_5, title = {Structural State Dependence in Social Assistance through the Lens of Couples’ Ethnic Composition : Evidence from Swedish Panel Data}, author = {Andrén, Daniela and Andrén, Thomas and Kahanec, Martin}, year = {2025}, url = {2003691}, language = {eng}, publisher = {Örebro University, School of Business}, keywords = {state dependence; social assistance; intra-ethnic; inter-ethnic; household}, abstract = {This study investigates whether couple ethnic composition shapes household welfare dependence, a relevant dimension overlooked in previous studies. Using fifteen years of Swedish panel data and a dynamic discrete-choice model that addresses initial-conditions and unobserved heterogeneity, we analyze structural state dependence in social assistance across households of intra-ethnic and inter-ethnic couples. Consistent with previous studies, we find that thatwelfare participation is much higher for foreign-born individuals in both intra- and inter-ethnic couples than for couples of natives. However, the lowest structural state dependence in social assistance was found for households of inter-ethnic couples, while individuals from couples of natives show the strongest state dependence, nearly five times higher than for households of couples comprising foreign-born women with Swedish-born men and stable couples of foreign-born men and Swedish-born women. Our findings offer important policy implications for addressing social assistance needs across diverse household configurations in increasingly multicultural and fiscally constrained societies. Policy and political discourse focused primarily on reducing immigrants’ welfare dependency may be misguided, as house-holds of native-born individuals exhibit stronger structural state dependence despite lower overall participation rates. Policymakers should broaden their focus to include households of couples of natives in efforts to reduce welfare persistence.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_pittapantazidemetra_2025, title = {Structure sense in students' quantity comparison and repeating pattern extension tasks : an eye-tracking study with first graders}, author = {Pitta-Pantazi, Demetra and Demosthenous, Eleni and Schindler, Maike and Lilienthal, Achim J. and Christou, Constantinos}, year = {2025}, journal = {Educational Studies in Mathematics}, volume = {118}, pages = {339--357}, doi = {10.1007/s10649-023-10290-5}, url = {1836032}, language = {eng}, publisher = {Springer}, keywords = {eye tracking; quantity comparison; repeating pattern extension; structure sense; serial strategies}, abstract = {There is growing evidence that the ability to perceive structure is essential for students' mathematical development. Looking at students' structure sense in basic numerical and patterning tasks seems promising for understanding how these tasks set the foundation for the development of later mathematical skills. Previous studies have shown how students use structure sense in enumeration tasks. However, little is known about students' use of structure sense in other early mathematical tasks. The main aim of this study is to investigate the ways in which structure sense is manifested in first-grade students' work across tasks, in quantity comparison and repeating pattern extension tasks. We investigated students' strategies in quantity comparison and pattern extension tasks and how students employ structure sense. We conducted an eye-tracking study with 21 first-grade students, which provided novel insights into commonalities among strategies for these types of tasks. We found that for both tasks, quantity comparison and repeating pattern extension tasks, strategies can be distinguished into those employing structure sense and serial strategies.}, issn = {0013-1954} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_schlegelkenny_2025, title = {Structured temporal representation in time series classification with ROCKETs and hyperdimensional computing}, author = {Schlegel, Kenny and Rachkovskij, Dmitri A. and Kleyko, Denis and Gayler, Ross W. and Protzel, Peter and Neubert, Peer}, year = {2025}, journal = {Data mining and knowledge discovery}, volume = {39}, number = {6}, doi = {10.1007/s10618-025-01162-y}, url = {2013265}, language = {eng}, publisher = {Springer}, keywords = {hyperdimensional computing; time series classification; rocket; minirocket; multirocket; hydra; position encoding; compositional representation}, abstract = {Time series classification poses significant challenges due to the inherent temporal order of the data points and the existence of sequential dependencies between them. The ROCKET family, featuring methods like MiniROCKET, MultiROCKET, and HYDRA, is currently a leading approach in this domain, leveraging convolution kernels to aggregate temporal features into encodings for linear classifiers. However, these models encode temporal features over short temporal windows and then aggregate them as an unordered set of encodings over the longer temporal window of the entire data sequence. This prevents these models from capturing any longer sequence structure. To address this design drawback, we propose integrating hyperdimensional computing into ROCKET methods to explicitly incorporate temporal order of the short-term features within the entire time series. This approach enhances the discriminative power of encodings generated by MiniROCKET, MultiROCKET, and HYDRA where longer-term structure exists in the data, leading to increased classification performance with minimal computational overhead. More specifically, we introduce a method to represent time series as high-dimensional vectors through multiplicative binding of ROCKET encodings with encodings representing temporal order, applying this approach across various ROCKET methods. Additionally, we explore different high-dimensional vector representations of temporal order, yielding diverse similarity kernels that enhance classification accuracy. Through experiments on synthetic datasets, we highlight the limitations of ROCKET methods in handling temporal dependencies and show how the methods based on hyperdimensional computing overcome these limitations. Furthermore, our extensive experimental evaluation with real-world datasets included in the recent UCR archive, validates the advantages of our approach, consistently achieving classification improvements across all ROCKET methods that integrate hyperdimensional computing. Notably, our best model achieves a relative error rate reduction of over 50% compared to the best ROCKET model on several UCR datasets.}, issn = {1384-5810} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_leonenkonikolain_2025, title = {Student Models for a Risky Asset with Dependence : Option Pricing and Greeks}, author = {Leonenko, Nikolai N. and Liu, Anqi and Shchestyuk, Nataliya}, year = {2025}, journal = {Austrian Journal of Statistics}, volume = {54}, number = {1}, pages = {138--165}, doi = {10.17713/ajs.v54i1.1952}, url = {1906032}, language = {eng}, publisher = {Österreichische Statistische Gesellschaft}, keywords = {option pricing; fractal activity time; student processes; dependence structure; supou processes; delta hedging}, abstract = {We propose several new models in finance known as the Fractal Activity Time Geometric Brownian Motion (FATGBM) models with Student marginals. We summarize four models that construct stochastic processes of underlying prices with short-range and long-range dependencies. We derive solutions of option Greeks and compare with those in the Black-Scholes model. We analyse performance of delta hedging strategy using simulated time series data and verify that hedging errors are biased particularly for long-range dependence cases. We also apply underlying model calibration on S&P 500 index (SPX) and the U.S./Euro rate, and implement delta hedging on SPX options.}, issn = {1026-597X} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hilmerbysren_2025, title = {Studentledda tillämpningsseminarier som modell för att träna kommunikationsförmåga och stärka programtillhörighet}, author = {Hilmerby, Sören and Sundhäll, Marcus and Ekengren, Jens and Karlsson, Patrik and Korin, Christer}, year = {2025}, pages = {85--94}, url = {2019372}, language = {swe}, publisher = {Blekinge Tekniska Högskola}, keywords = {länkning; programtillhörighet; kommunikations- och samarbetsförmåga; studentledda seminarier}, abstract = {Förmågan att kommunicera och samarbeta över olika gränser är en nyckelkompetens för blivande ingenjörer, samtidigt som känslan av tillhörighet till det egna utbildningsprogrammet är central för studenternas motivation och engagemang. I denna studie har vi utvecklat och prövat en modell i form av studentledda tillämpningsseminarier, där äldre studenter fungerar som seminarieledare för yngre studenter. Syftet har varit att skapa aktiviteter som både tränar kommunikations- och samarbetsförmåga och stärker programtillhörigheten genom länkning mellan kurser och årskurser. Aktiviteten genomfördes med tredjeårsstudenter som seminarieledare och med förstaårsstudenter som deltagare i en kurs i mekanik. Aktiviteten utvärderades genom intervjuer, enkäter och kursansvarigas observationer. Resultaten visar att seminarieledarna upplevde aktiviteten som meningsfull träning i att anpassa kommunikation till en annan målgrupp och att seminariedeltagarna uppskattade kontakten med mer erfarna studenter, vilket bidrog till inspiration och ökad förståelse för programmet som helhet. Samtidigt framkom utmaningar, bland annat variationer i svårighetsgrad och förberedelser mellan grupperna. Slutsatsen är att modellen är resurseffektiv, uppskattad av både studenter och lärare och kan återanvändas med vissa justeringar. Den erbjuder ett konkret sätt att både främja kommunikativa färdigheter och stärka studenters programtillhörighet. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_skoglundanne_2025, title = {Students' descriptions about experiences beneficial to mental health - a thematic analysis}, author = {Skoglund, Anne and Hotham, Sarah and Schröder, Agneta and Moen, Øyfrid Larsen}, year = {2025}, journal = {BMC Public Health}, volume = {25}, number = {1}, doi = {10.1186/s12889-025-21846-w}, url = {1938924}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {mental health; mental health promotion; students; universities}, abstract = {University years are an important transitional time for young adults. Recently, an increasing number of students have reported mental health problems. The increasing numbers are an international phenomenon. Qualitative research on mental health promotion for students is, however, scarce. The aim of this study is to explore students' descriptions of experiences in their student life that are beneficial to mental health. A Norwegian project named "In my experience" collected descriptions, through the web-based tool Sensemaker, from students about experiences that have had an impact on their student life. This study explores the descriptions of experiences beneficial to students' mental health that the students categorized as having had a positive or very positive impact on their student life. A total of 171 descriptions from students aged 18-29 were analyzed using thematic analysis. Two main themes were identified: becoming a student, which consisted of descriptions about the feeling of a new life as a student, and being a student, which described experiences with managing student life that were beneficial for mental health. Experiences such as being welcomed, being included, belonging to a social group, finding one's own identity, maturing, and developing were all highlighted in the descriptions. Student societies and other forms of civic engagement and being accepted and included in an academic community were fundamental. A limitation of the study was the relatively low number of male participants, and further research on male students' descriptions about beneficial experiences is needed.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_baderbrittmarie_2025, title = {Students' Perspectives on Individual Development Dialogues}, author = {Bader, Britt-Marie and Ehrlin, Anna}, year = {2025}, url = {1955198}, language = {eng}, file = {https://oru.diva-portal.org/smash/get/diva2:1955198/FULLTEXT01.pdf} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_prosnsara_2025, title = {Studies on expression profiles in keratinocyte cancers with focus on basal cell carcinoma}, author = {Prosén, Sara}, year = {2025}, url = {1921084}, language = {eng}, publisher = {Örebro University}, keywords = {keratinocyte cancer; non-melanoma skin cancer; basal cell carcinoma; cutaneous squamous cell carcinoma; slc25a43; lat1}, abstract = {Aims: This thesis aimed to investigate metabolic changes in keratinocyte carcinoma with a focus on basal cell carcinoma (BCC), to find potential treatment targets.Material and Methods: Patients diagnosed with BCC (n=55) or cutaneous squamous cell carcinoma (cSCC, n=4) were included. Snap-frozen tumour tissue from BCC tumours, formalin-fixed paraffin-embeddedt issue from BCC and cSCC tumours, and donor skin were investigated with quantitative real-time polymerase chain reaction (qPCR), microarray analysis, immunohistochemistry, and immunofluorescence. Cell lines from BCC, cSCC, and non-neoplastic keratinocytes were used to examine LAT1 inhibition with JPH203 in terms of decreased viability and changed gene expression in genes important for cell metabolism and carcinogenesis.Results: SLC25A43 gene- and protein expression were significantly decreased in the BCC tumour samples (n=14) compared to the surrounding epidermis. Microarray examination of the tumour material (n=4+4) revealed increased expression of the amino acid transporters SLC7A5/LAT1 and SLC7A8/LAT2, which was confirmed with qPCR(n=14) and immunohisto chemistry (n=14). The LAT1 expression was mainly in the centre of the tumours, and the fraction of LAT1-positive cells were significantly (p<0.01) inversely correlated to the proliferative active cells. Cleaved caspase 3 was significantly (p=0.02) increased in tumour areas with high LAT1 expression. In the patient cohort (n=57), the H-score for LAT1 was significantly higher (p<0.001) than for GLUT1 or GLI1. A sub-analysis of the BCC tumours also revealed a statistically significant correlation (p<0.01) between LAT1 and GLUT1 protein expression. The keratinocyte cell line (HEK001) showed significantly decreased viability when exposed to the LAT1 inhibitor JPH203 at concentration of 100 μM, and a low but significant upregulation of SLC7A5, SLC3A2, CCND1, ATF4 and GLI1 when exposed to a concentration of 10 μM JPH203.Conclusions: Both SLC25A43 and LAT1 are altered in BCC tumoursc ompared to normal skin suggesting metabolic changes in the tumours. The changed LAT1 expression might be explained by the harsh tumour environment. LAT1 could be a drug target for keratinocyte cancer, but needs further investigations in more advanced models.}, file = {https://oru.diva-portal.org/smash/get/diva2:1921084/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hosanggeorginam_2025, title = {Subclinical hypomania, psychiatric and neurodevelopmental diagnoses : phenotypic and aetiological overlap}, author = {Hosang, Georgina M. and Martini, Miriam I. and Ronald, Angelica and Larsson, Henrik and Lundström, Sebastian and Lichtenstein, Paul and Taylor, Mark J.}, year = {2025}, journal = {Journal of Child Psychology and Psychiatry}, doi = {10.1111/jcpp.70045}, url = {1995793}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {hypomania; genetic; neurodevelopmental conditions; psychiatric illnesses; twin study}, abstract = {BACKGROUND: Subclinical hypomanic symptoms are fairly common in the general population but are linked to psychiatric and neurodevelopmental conditions. However, the genetic and environmental origins of these associations are unclear. This twin study examined the phenotypic and aetiological associations between subclinical hypomania and psychiatric and neurodevelopmental diagnoses.METHODS: Participants were 4,932 twin pairs from the Child and Adolescent Twin Study in Sweden. Hypomanic symptoms were assessed using the parent-rated Mood Disorders Questionnaire when the twins were aged 18. Specialist diagnoses of 14 conditions and symptoms were ascertained from Swedish population registries. Phenotypic associations between hypomania and these conditions/symptoms were investigated, and their aetiological overlap was examined using the twin method.RESULTS: Subclinical hypomania was significantly associated with all 14 diagnoses. The highest odds were for psychotic disorders (odds ratio [OR] = 1.48, 95% confidence intervals [CI] = 1.33-1.64, p < .001). The genetic correlations between subclinical hypomania and these diagnoses ranged from 0.12 (95% CI: 0.04-0.33) for eating disorders (other than anorexia) to 0.58 (95% CI: 0.28-1.00) for drug misuse disorders. The nonshared environmental correlations were highest for psychotic disorders (0.52, 95% CI: -0.02 to 0.92) and lowest for body dissatisfaction (0.04, 95% CI: -0.01 to 0.08). For bipolar disorder, psychotic disorders, and attention deficit hyperactivity disorder, genetic, and nonshared environmental correlations with subclinical hypomania were of a similar magnitude.CONCLUSIONS: The association between subclinical hypomania and the diagnosis of multiple psychiatric phenotypes highlights its important role in the developmental pathway to clinical disorders, its complex origins, and that it may represent a quantitative trait for various psychiatric phenotypes.}, issn = {0021-9630} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_shchestyuknataliya_2025, title = {Subdiffusive option price model with Inverse Gaussian subordinator}, author = {Shchestyuk, Nataliya and Tyshchenko, Sergii}, year = {2025}, journal = {Modern Stochastics: Theory and Applications (MSTA)}, volume = {12}, number = {2}, pages = {135--152}, doi = {10.15559/24-VMSTA265}, url = {1947922}, language = {eng}, publisher = {VTeX, Vilniaus Universitetas}, keywords = {option pricing; subdiffusion models; subordinator; inverse subordinator; time-changed process; hitting time}, abstract = {The paper focuses on the option price subdiffusive model under the unusual behavior of the market, when the price may not be changed for some time, which is a quite common situation in modern illiquid financial markets or during global crises. In the model, the risk- free bond motion and classical geometrical Brownian motion (GBM) are time-changed by an inverted inverse Gaussian(IG) subordinator. We explore the correlation structure of the subdiffusive GBM stock returns process, discuss option pricing techniques based on the martingale option pricing method and the fractal Dupire equation, and demonstrate how it applies in the case of the IG subordinator.}, issn = {2351-6046} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_andrndaniela_2025_6, title = {Subjective wellbeing and suicide prevention resource allocation}, author = {Andrén, Daniela and Pettersson, Nicklas}, year = {2025}, journal = {European Journal of Public Health}, volume = {35}, number = {Suppl. 4}, doi = {10.1093/eurpub/ckaf161.202}, url = {2014457}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background: Healthcare resource allocation often prioritizes economic efficiency, but alternative approaches emphasizing ethics, social justice, and needs are equally important. This study investigates how subjective well-being, personal experiences with health conditions, and resource allocation decisions relate to saving lives of individuals at risk from various health conditions.Methods: Data were collected from 1,000 Swedish respondents via a web survey during December 2021-January 2022, amid the Omicron wave of COVID-19. The survey included a discrete choice experiment (DCE) designed to identify preferences for allocating limited healthcare resources to save lives threatened by suicide, pancreatic cancer, breast cancer, and acute heart attack. Additional questions captured socio-demographic characteristics, personal experiences, attitudes, and life satisfaction.Results: Our results suggest that respondents with high life satisfaction and no personal experience with the four health conditions prioritized allocating limited healthcare resources to relatively young people, but not to suicide prevention. Public preferences correlated with life satisfaction levels, with those reporting higher life satisfaction placing lower value on suicide prevention compared to saving lives from other conditions.Conclusions: Public preferences for healthcare resource allocation are influenced by both life satisfaction and personal experiences with health conditions. These findings highlight the importance of incorporating public preferences and subjective well-being measures in healthcare priority-setting frameworks, particularly when allocating limited resources during public health crises.}, issn = {1101-1262} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_drakenberganna_2025_1, title = {Supportive care for families in open-heart surgery : professional attitudes, family-important situations, and a conversation model evaluation}, author = {Drakenberg, Anna}, year = {2025}, url = {1934377}, language = {eng}, publisher = {Örebro University}, keywords = {critical incident technique; family-centered care; family involvement; family systems nursing; mixed methods; open-heart surgery; randomized clinical trial; social support}, abstract = {Open-heart surgery is known to affect not only the patient, but also his or her family members. Therefore, family involvement in relation to this surgical procedure ought to be supported. Attention should be paid to the whole family’s well-being. There is a lack of research on how this should be done in current open-heart surgical care settings. The overall aim was to describe, explore, evaluate, and interpret family involvement in relation to patients undergoing open-heart surgery using social support theory. Study I had a mixed-methods convergent parallel design and was conducted through integrating one cross-sectional and two qualitative datasets describing registered nurses’ (n = 267) and licensed physicians’ (n = 20) attitudes toward family involvement in open-heart surgical care. Descriptive qualitative data were analyzed using the critical incident technique to explore patients’ (n =35) (Study II) and family members’ (n = 29) (Study III) experiences and actions regarding family involvement. In Study IV, quantitative data were analyzed in a randomized clinical trial to evaluate the effects of the family health conversations when delivered to patients with their family members via videoconferencing. The primary analysis was based on questionnaire responses from 101 patients (control = 54, intervention = 47) and 99 of their family members (control = 52, intervention = 47). The results of Study I–IV were synthesized by applying a mixed-methods approach. The synthesized findings showed that family involvement in open-heart surgical care entails social and professional supportive aspects. Family involvement is a concept that also has unsupportive aspects. Patients and family members have needs connected to all these aspects that can be met by family-centered care policy and intervention. The family health conversations is one intervention that has potential to meet the needs of families in this context. In addition to the implementation of family-centered policies, the findings support a team approach to supportive conversations in open-heart surgical care and further exploration and evaluation of peer support programs in this context.}, file = {https://oru.diva-portal.org/smash/get/diva2:1934377/FULLTEXT01.pdf;https://oru.diva-portal.org/smash/get/diva2:1934377/FULLTEXT04.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_drakenberganna_2025_2, title = {Supportive care for families in open-heart surgery : professional attitudes, family-important situations, and a conversation model evaluation}, author = {Drakenberg, Anna}, year = {2025}, url = {2024243}, language = {swe}, publisher = {Svensk thoraxkirurgisk förening} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alakmeharon_2025, title = {Surgeon-specific differences in recurrence rates among patients undergoing burr hole evacuation for chronic subdural hematoma}, author = {Alakmeh, Aron and Stumpo, Vittorio and Voglis, Stefanos and Spinello, Antonio and El-Hajj, Victor Gabriel and Elmi-Terander, Adrian and Regli, Luca and Serra, Carlo and Staartjes, Victor E. and Vasella, Flavio}, year = {2025}, journal = {Brain and Spine}, volume = {5}, doi = {10.1016/j.bas.2025.105634}, url = {2009494}, language = {eng}, publisher = {Elsevier}, keywords = {burr hole; chronic subdural hematoma; hygroma; recurrence; surgeon differences}, abstract = {INTRODUCTION: Chronic subdural hematoma (cSDH) frequently recurs. Numerous studies have investigated the influence of various factors on the likelihood of recurrence, yet the potential influence of individual surgeon identity beyond general experience level remains unclear. RESEARCH QUESTION: To evaluate whether surgeon-specific differences contribute to recurrence rates whilst accounting for standardized technique and known patient-/procedure-related factors.MATERIALS AND METHODS: Retrospective analysis of burr hole evacuation for cSDH or hygroma at a single tertiary center. Standardized surgical technique involved two burr holes with subdural lavage and drainage placement. Primary outcome was symptomatic recurrence necessitating redo surgery. Surgeon-specific variability in recurrence was assessed via three statistical methods: risk-standardized observed-to-expected (O/E) ratios, logistic generalized estimating equations (GEE), and hierarchical Bayesian logistic modeling, adjusted for covariates.RESULTS: Among 116 patients (age = 78.0 years, 75.0 % = male, 26.7 % = bilateral procedures), symptomatic recurrence occurred in 15 cases (12.9 %). Risk-standardized-O/E recurrence ratios varied from 0.00 to 1.65, with wide confidence intervals indicating uncertainty, but all within expected ranges (median O/E = 1.11, IQR = 0.60-1.45). GEE analysis demonstrated significant surgeon-specific clustering (ICC = 0.61, large effect), indicating between-surgeon differences could explain more than half of the remaining variance in recurrence. Bayesian hierarchical modeling showed moderate surgeon-specific clustering with an ICC = 0.14, indicating that between-surgeon differences accounted for approximately 14 % of total variance in recurrence.DISCUSSION AND CONCLUSIONS: Our study demonstrates modest yet measurable surgeon-specific differences in recurrence rates following standardized burr-hole evacuation for cSDH. These findings support further investigation into surgeon-specific variability, particularly for more complex procedures, to identify actionable technical differences and optimize surgical outcomes universally.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_liyaxin_2025, title = {Surgical Recovery Through the Lens of Patients with Colorectal Disease : A Qualitative Study in an Enhanced Recovery after Surgery Setting}, author = {Li, Yaxin and Hajar, Rana and Gramlich, Leah and Nelson, Gregg and Ljungqvist, Olle and Gillis, Chelsia}, year = {2025}, journal = {Journal of the American College of Surgeons}, volume = {240}, number = {1}, pages = {11--23}, doi = {10.1097/XCS.0000000000001218}, url = {1922401}, language = {eng}, publisher = {Wolters Kluwer}, abstract = {BACKGROUND: As perioperative care shifts to a more patient-centered model, understanding needs and experiences of patients is vital. Gaining such insight can enhance the alignment of care with patient priorities, encouraging adherence to recovery-oriented interventions. We aimed to explore patient-defined recovery and the elements that modify the recovery process for patients with colorectal disease under Enhanced Recovery After Surgery (ERAS) care.STUDY DESIGN: A qualitative study was conducted at an ERAS-participating hospital in Alberta, Canada, between April 2018 to June 2019. A co-design focus group set the research direction and semi-structured interviews were conducted postoperatively in hospital or within 3 months post-discharge. Diverse patient ages and colorectal conditions were targeted through purposive sampling. Interviews were transcribed verbatim and analyzed through manifest and latent content analysis.RESULTS: Twenty patients with mean age 62 (SD:13) years and 45% with cancer (n=17 interview, n=2 focus group and interview, n=1 focus group only) were enrolled. Recovery was defined by patients as the return to normal routines and four themes were identified. First, Phases of recovery: recovery was described as multidimensional phases distinctively as early, late/long-term, and the endpoint. Second, Recovery facilitators: recovery was supported through positive mindsets, conscious recovery, and taking an active role. Third, Recovery barriers: recovery was hindered by negative mindsets and treatment side-effects. Finally, Recovery catalysts: communication, autonomy, and expectations facilitated active or passive recovery.CONCLUSION: Our patient-oriented recovery model may contribute a new dimension to the ERAS framework by capturing patients' recovery experiences. Further research is encouraged to explore its value in enhancing patient-centered care within ERAS.}, issn = {1072-7515} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_katawazaiasmatullah_2025_6, title = {Surgical Treatment of Ventral Hernia and Rectus Diastasis}, author = {Katawazai, Asmatullah}, year = {2025}, url = {1934333}, language = {eng}, publisher = {Örebro University}, keywords = {ventral hernia; rectus abdominis diastasis; quality of life}, abstract = {Background: Postpartum rectus abdominis diastasis (PP-RAD) and primary ventral hernias (PVH) are closely related in women. PP-RAD is caused by separation of the rectus abdominis muscles following pregnancy, leading to core instability and an increased risk of hernia formation. PP-RAD can significantly affect quality of life. The aim of this thesis was to evaluate the risk factors for ventral hernia formation and recurrence. The surgical interventions presented in the thesis aimed to reduce complication and recurrence rates and to improve the quality of life for female patients affected by PP-RAD.Paper I aimed to evaluate reoperation rates due to recurrence in ventral hernia repairs across different genders, ages, and surgical methods. The study concluded that women and patients younger than 50 had significantly higher reoperation rates regardless of repair method.Paper II evaluated the impact of parity and delivery method on risk of PVH. A register study on >1.5 million women. The study concluded that risk of hernia repair increased with number of pregnancies and cesarean sections were associated with higher rate of hernia repairs.Paper III and IV are based on prospective studies evaluating a new Minimally Incision Repair method of Rectus Abdominis Diastasis (MIRRAD) as a day-case surgery. Paper III concluded that MIRRAD is a safe and effective method that can be performed on an outpatient basis, offering a less invasive option for repairing PPRAD.Paper IV examined the impact of the MIRRAD procedure on patients' quality of life. The findings showed a significant improvement in the quality of life for women with PP-RAD.Paper V is an RCT of 205 procedures comparing the safety and efficacy of placinga ventral hernia patch in the preperitoneal space with repairing with non-absorbable barbed sutures. The study concluded that preperitoneal ventral hernia patch is a safe and effective method with a lower recurrence rate compared to barbed suture repair.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_holymarek_2025_1, title = {Surgically treated degenerative cervical spine diseases in twins}, author = {Holy, Marek and Szigethy, Lilla and Wretenberg, Per and MacDowall, Anna and Sigmundsson, Freyr Gauti and Joelson, Anders}, year = {2025}, journal = {European spine journal}, volume = {34}, number = {4}, pages = {1270--1274}, doi = {10.1007/s00586-025-08731-1}, url = {1938332}, language = {eng}, publisher = {Springer}, keywords = {cervical disk herniation; cervical foraminal stenosis; concordance; degenerative cervical myelopathy; heredity; twin study}, abstract = {PURPOSE: Genetic factors are considered important in the development of degenerative spine disease. The aim of this study was to determine the twin concordance rates for the common cervical spine diseases cervical disk herniation (CDH), cervical foraminal stenosis (CFS), and degenerative cervical myelopathy (DCM) requiring surgical treatment by studying monozygotic (MZ) and dizygotic (DZ) twin pairs.METHODS: Patients, aged 18-85 years, operated for CDH, CFS, or DCM between 1996 and 2022 were identified in the national Swedish spine register (5962 CDH, 3801 CFS, and 3131 DCM) and matched with the Swedish twin registry to identify MZ and DZ twins. Concordance rates were calculated.RESULTS: There were 64 twin pairs where one or both twins had surgical treatment for CDH. The corresponding numbers for surgically treated CFS and DCM were 37 twin pairs and 44 twin pairs respectively. For twins with CDH we found one concordant MZ pair and no concordant DZ pair (MZ probandwise concordance rate 0.12 [95% CI 0-0.33]). For twins with CFS we found one concordant MZ pair and no concordant DZ pair (MZ probandwise concordance rate 0.14 [95% CI 0-0.38]). In DCM patients we found no concordant twin pair.CONCLUSIONS: In this national observational study, including 145 twin pairs, the concordance rates were low for surgically treated CDH, CFS, and DCM conditions. Our findings suggest that not only genetic factors, but also environmental factors and personal preferences are important whether a patient goes to surgery for this type of condition.}, issn = {0940-6719} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jansonchrister_2025, title = {Survival in COPD Patients Treated with Home Mechanical Ventilation : Results from the DISCOVERY Study}, author = {Janson, Christer and Emilsson, Össur and Grote, Ludger and Ljunggren, Mirjam and Sundh, Josefin and Ekström, Magnus and Palm, Andreas}, year = {2025}, journal = {European Respiratory Journal}, volume = {66}, number = {Suppl. 69}, doi = {10.1183/13993003.congress-2025.PA1550}, url = {2037707}, language = {eng}, publisher = {European Respiratory Society}, abstract = {Background: Current guidelines recommend initiating home mechanical ventilation (HMV) electively in patients with chronic obstructive pulmonary disease (COPD) and persistent hypercapnia. However, in clinical practice, HMV is often initiated acutely related to an exacerbation. This study compares survival outcomes in COPD patients who initiated HMV acutely versus electively.Methods: This national, population-based cohort study included patients with severe COPD (FEV₁ <50% predicted) who initiated HMV between 1996 and 2022 in the Swedish Registry for Respiratory Failure (Swedevox). Data were cross-linked with mandatory national registries. Mortality was analysed using Cox regression, adjusting for demographics, lung function, PaCO₂, comorbidities, and year of treatment initiation of HMV.Results: Of 861 patients (66% women, mean±SD age 69.4 ± 6.8 years), 533 (62%) initiated HMV acutely after an exacerbation, while 328 (38%) started electively. Patients starting HMV in an acute setting had lower 5-year survival than the elective group (29% [95% CI: 3–25] versus 44% [4–38]; p<0.001). This survival difference remained significant after adjustment, hazard ratio [HR] 1.23 (95% CI: 1.01–1.50). Other factors associated with increased mortality included BMI <22 (HR 1.57 (1.25-1.97), ischemic heart disease (HR 1.42 (1.13-1.79) using supplemental oxygen (HR 1.31 (1.08-1.59) as well as higher age, lower FEV and higher PaCO₂,Conclusion: This national study of patients with COPD shows that the majority (62%) of HMV is initiated acutely after an exacerbation. Acute initiation was associated with higher mortality than elective start.}, issn = {0903-1936} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_johnstoneleanne_2025_6, title = {Sustainability controlling practices in small businesses – Experiences from Scandinavian fish restaurants}, author = {Johnstone, Leanne and Poulsen, Morten}, year = {2025}, url = {1955315}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_noordveldmilan_2025, title = {Sustainable mobility policy on a rural-urban spectrum : exploring spatial differentiation within the Swedish context}, author = {Noordveld, Milan and Fil Kristensen, Iryna and Adjei, Evans Korang}, year = {2025}, journal = {European Planning Studies}, volume = {33}, number = {10}, pages = {1779--1800}, doi = {10.1080/09654313.2025.2525486}, url = {1985473}, language = {eng}, publisher = {Routledge}, keywords = {sustainable mobility; personal vehicles; car use; policy differentiation; electric vehicles; sweden; o18; o21}, abstract = {The continued reliance on cars presents a challenge for sustainable mobility policy. A wide range of approaches exists to address this issue, from promoting more sustainable vehicle options to replacing cars altogether. However, national sustainable mobility policies related to car use often suffer from spatial blindness - which implies a limited contextual differentiation based on the specific characteristics of the area in which they are implemented. Enhancing policy differentiation may improve policy effectiveness. The aim of this paper is to systematically review the literature on sustainable mobility policies and explore practical approaches to achieving greater policy differentiation, using Sweden as a pilot case. Our findings suggest that existing sustainable mobility policies, typically based on a common urban-rural distinction, can be adapted to a spatially differentiated spectrum that considers variations in population density. This study contributes a practice-oriented perspective to the discussion on policy differentiation, articulated through a policy model that integrates quantitative analysis and a literature review. Additionally, it provides a review of potential sustainable mobility policy measures and examines their applicability across different spatial contexts.}, issn = {0965-4313} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_silanderdaniel_2025, title = {Svensk politik och EU : Hur svensk politik har förändrats av medlemskapet i EU}, author = {Silander, Daniel and Öhlén, Mats}, year = {2025}, url = {1953886}, language = {swe}, publisher = {Santérus Förlag} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_angelinanna_2025, title = {Sveriges växande problem med icke-mottagande : Om konsekvenserna av att allt fler människor faller utanför skyddsnätet}, author = {Angelin, Anna and Vamstad, Johan and Brauer, John}, year = {2025}, pages = {38--43}, url = {2008611}, language = {swe}, publisher = {Sveriges Stadsmissioner}, abstract = {Socialtjänsternas ekonomiska bistånd är ett område inom den svenska välfärdsstaten som brister. Allt färre får ekonomiskt bistånd trots att hushållens ekonomi försämrats vilket delvis förklaras av att personer som har rätt till hjälp inte får det. Detta fenomen kallas icke-mottagande och i denna text vill vi visa på icke-mottagandets konsekvenser för individer, samhället i stort samt civilsamhället.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ringlanderjohan_2025, title = {Swedish guidelines for the management and treatment of patients with hepatitis D (delta) virus infection 2025}, author = {Ringlander, Johan and Aleman, Soo and Duberg, Ann-Sofi and Eilard, Anders and Fischler, Björn and Kamal, Habiba and Kampmann, Christian and Lindahl, Karin and Lindh, Magnus and Westin, Johan}, year = {2025}, journal = {Infectious Diseases}, doi = {10.1080/23744235.2025.2604034}, url = {2024418}, language = {eng}, publisher = {Taylor & Francis}, issn = {2374-4235} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ullnanders_2025, title = {Swedish national guidelines on urothelial carcinoma : 2024 update on advanced and metastatic disease}, author = {Ullén, Anders and Aljabery, Firas and Dahlman, Pär and Falkman, Karin and Gårdmark, Truls and Jerlström, Tomas and Holst, Susanna and Kjellström, Sofia and Lind, Anna-Karin and Papantoniou, Dimitrios and Stenlund, Jonas and Ströck, Viveka and Söderkvist, Karin and Thulin, Helena and Trägårdh, Elin and Verbiene, Ingrida and Wallström, Jonas and Öfverholm, Elisabeth and Liedberg, Fredrik}, year = {2025}, journal = {Scandinavian journal of urology}, volume = {60}, pages = {76--82}, doi = {10.2340/sju.v60.43236}, url = {1947473}, language = {eng}, publisher = {Taylor & Francis}, keywords = {bladder cancer; guidelines; advanced; metastatic}, abstract = {OBJECTIVE: To overview and summarise the Swedish National Guidelines on Urothelial Carcinoma 2024.METHODS: A narrative review of the updated guidelines was performed, highlighting new treatment recommendations for advanced and metastasized disease. Results: Compared to the previous guideline version, the current update includes recommendations for standardised radiological reporting when urothelial carcinomas are detected at CT-urography (CTU), to early identify locally advanced patients and accelerate the care pathway for these patients. The Swedish guidelines apply a more structured and liberal recommendation for the use of 18F-fluorodeoxyglucose-positron emission tomography/computed tomography in patients with locally advanced urothelial carcinomas compared to the EAU-guidelines and recommend such examinations prior to transurethral resection. Improved outcomes for radical cystectomy in Sweden after centralised cystectomy care have led to a recommendation for performing more than six nephroureterectomies (NUs) per year for upper tract urothelial carcinomas (UTUC)-based associations with decreased use of invasive diagnostic modalities and better survival outcomes. Additionally, updated recommendations regarding adjuvant systemic therapies for muscle-invasive disease have been included. Whilst awaiting national regulatory approval for enfortumab vedotin/pembrolizumab, the present guideline version aligns with EAU-guidelines by endorsing cisplatin-gemcitabine-nivolumab as a new first-line treatment option in cisplatin-fit patients with unresectable or metastatic urothelial carcinoma.CONCLUSIONS: The current version of the Swedish national guidelines on urothelial carcinoma introduces standardised reporting at CTU to facilitate early identification of advanced disease, includes recommendations for centralisation of NU for UTUC and updated recommendations for adjuvant systemic treatment of muscle-invasive disease and endorses cisplatin-gemcitabine-nivolumab as a new first-line treatment option for non-resectable locally advanced and metastatic disease.}, issn = {2168-1805} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_widehammarcathrine_2025, title = {Swedish translation, cultural adaptation and testing of the Prosthetic Upper Extremity Functional Index-2}, author = {Widehammar, Cathrine and Sjöberg, Lis}, year = {2025}, journal = {Journal of rehabilitation medicine. Clinical communications}, volume = {8}, doi = {10.2340/jrm-cc.v8.42151}, url = {1972236}, language = {eng}, keywords = {outcome measure; paediatrics; rehabilitation; upper limb prosthetics}, abstract = {OBJECTIVE: We aimed to translate, culturally adapt and test the Prosthetic Upper Extremity Functional Index-2 for a Swedish context.SUBJECTS: Ten children with congenital upper limb deficiency with an upper limb prosthesis and their parents.METHODS: The translation and cultural adaptation of the Prosthetic Upper Extremity Functional Index-2 was conducted according to the International Society for Pharmacoeconomics and Outcomes Research Principles of Good Practice for cross-cultural adaptation of patient-reported outcome measures; this comprises 10 steps, including Preparation, Forward Translation, Reconciliation, Back Translation, Back Translation Review, Harmonization, Cognitive Debriefing, Review of Cognitive Debriefing Results and Finalization, Proofreading and Final Report.RESULT: The new translated version, tested on 10 children, 4 boys and 6 girls, 3-14 years showed good relevance for the Swedish context, the questions were easy to understand, and response options were easy to interpret. It was also easily accessible on computers and mobile devices.CONCLUSION: The Swedish version of the Prosthetic Upper Extremity Functional Index-2 is user-friendly and provide information of the child's self-reported prosthesis use in a Swedish context. Children's right to express their opinions, is crucial, and using the questionnaire prior to their clinic visits gives children the opportunity to participate in goal setting and treatment planning.}, issn = {2003-0711} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wesenhagenkirstenej_2025, title = {Synaptic protein CSF levels relate to memory scores in individuals without dementia}, author = {Wesenhagen, Kirsten E. J. and de Leeuw, Diederick M. and Tomassen, Jori and Gobom, Johan and Bos, Isabelle and Vos, Stephanie J. B. and Martinez-Lage, Pablo and Tainta, Mikel and Popp, Julius and Peyratout, Gwendoline and Tsolaki, Magda and Vandenberghe, Rik and Freund-Levi, Yvonne and Verhey, Frans and Lovestone, Simon and Streffer, Johannes and Dobricic, Valerija and Blennow, Kaj and Scheltens, Philip and Smit, August B. and Bertram, Lars and Teunissen, Charlotte E. and Zetterberg, Henrik and Tijms, Betty M. and Visser, Pieter Jelle}, year = {2025}, journal = {Alzheimer's Research & Therapy}, volume = {17}, number = {1}, doi = {10.1186/s13195-025-01703-z}, url = {1942049}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {cerebrospinal fluid proteomics; early alzheimer’s disease; memory performance; synaptic proteins}, abstract = {BACKGROUND: We investigated how cerebrospinal fluid levels of synaptic proteins associate with memory function in normal cognition (CN) and mild cognitive impairment (MCI), and investigated the effect of amyloid positivity on these associations.METHODS: We included 242 CN (105(43%) abnormal amyloid), and 278 MCI individuals (183(66%) abnormal amyloid) from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery (EMIF-AD MBD) and the Alzheimer's Disease Neuroimaging Initiative (ADNI). For 181 (EMIF-AD MBD) and 36 (ADNI) proteins with a synaptic annotation in SynGO, associations with word learning recall were analysed with linear models.RESULTS: Subsets of synaptic proteins showed lower levels with worse recall in preclinical AD (EMIF-AD MBD: 7, ADNI: 5 proteins, none overlapping), prodromal AD (EMIF-AD MBD only, 27 proteins) and non-AD MCI (EMIF-AD MBD: 1, ADNI: 7 proteins). The majority of these associations were specific to these clinical groups.CONCLUSIONS: Synaptic disturbance-related memory impairment occurred very early in AD, indicating it may be relevant to develop therapies targeting the synapse early in the disease.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mohantysoumitra_2025, title = {Synthetic antimicrobial peptide LD4-PP protects the host against E. coli-induced cell death}, author = {Mohanty, Soumitra and Kerr White, John and Yin, Yundi and Muhammad, Taj and Demirel, Isak and Strömstedt, Adam A. and Gunasekera, Sunithi and Ferraz, Natalia and Göransson, Ulf and Brauner, Annelie}, year = {2025}, journal = {Frontiers in Immunology}, volume = {16}, doi = {10.3389/fimmu.2025.1705805}, url = {2019489}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {e. coli; synthetic antimicrobial peptide; immune response; urinary tract infection; innate immunity}, abstract = {With antibiotic resistance being a major global concern, there is a huge need of new treatment options to fight bacterial infections. In this study, we highlight the antibacterial and host-protective roles of a novel synthetic antimicrobial peptide in uropathogenic Escherichia coli–infected uroepithelial cells. This peptide, designed from a fragment of human cathelicidin LL-37 and named LD4-PP, was found to be highly potent against clinical isolates of E. coli as well as ESBL-producing and multi-drug resistant E. coli. Additionally, LD4-PP inhibited the formation of new biofilm, damaging both the bacterial surface and the bacterial genome. LD4-PP also modulated the host cell lipid vacuole, caveolin-1, and Rho GTPase B affecting bacterial survival. Furthermore, LD4-PP exerts immunomodulatory effects by modulating free radical formation, expression of antioxidants, and inflammasome-mediated cell death. Pronounced uroepithelial cell death was observed after E. coli infection which was significantly inhibited by LD4-PP without affecting the cellular toxicity. Overall, the peptide LD4-PP is shown to be a strong candidate for future clinical applications, particularly to prevent and treat urinary tract infections.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_chenqi_2025, title = {Systems-level immunomonitoring in children with solid tumors to enable precision medicine}, author = {Chen, Qi and Zhao, Binbin and Tan, Ziyang and Hedberg, Gustav and Wang, Jun and Gonzalez, Laura and Mugabo, Constantin Habimana and Johnsson, Anette and Negrini, Erika and Páez, Laura Piñero and Rodriguez, Lucie and James, Anna and Chen, Yang and Mikeš, Jaromír and Bernhardsson, Anna Karin and Reitzner, Stefan Markus and von Walden, Ferdinand and O'Neill, Olivia and Barcenilla, Hugo and Wang, Chunlin and Davis, Mark M. and Carlson, Lena-Maria and Pal, Niklas and Blomgren, Klas and Repsilber, Dirk and Herold, Nikolas and Lakshmikanth, Tadepally and Kogner, Per and Ljungblad, Linda and Brodin, Petter}, year = {2025}, journal = {Cell}, volume = {188}, number = {5}, pages = {1425--1440.e11}, doi = {10.1016/j.cell.2024.12.014}, url = {1931543}, language = {eng}, publisher = {Cell Press}, keywords = {wilms tumor; cancer immunotherapy; human immunology; immune development; immunotherapy; neuroblastoma; oncology; pediatric; systems immunology}, abstract = {Cancer is the leading cause of death from disease in children. Survival depends not only on surgery, cytostatic drugs, and radiation but also on systemic immune responses. Factors influencing these immune responses in children of different ages and tumor types are unknown. Novel immunotherapies can enhance anti-tumor immune responses, but few children have benefited, and markers of effective responses are lacking. Here, we present a systems-level analysis of immune responses in 191 children within a population-based cohort with diverse tumors and reveal that age and tumor type shape immune responses differently. Systemic inflammation and cytotoxic T cell responses correlate with tumor mutation rates and immune cell infiltration. Clonally expanded T cell responses are rarely detected in blood or tumors at diagnosis but are sometimes elicited during treatment. Expanded T cells are similarly regulated in children and adults with more immunogenic cancers. This research aims to facilitate the development of precision immunotherapies for children with cancer.}, issn = {0092-8674} } @book{ca0f099bbf2a435cee8f97bef5e8cbaa_olsenlarsandr_2025, title = {Säker läkemedelsberäkning : dos, styrka, mängd}, author = {Olsen, Lars André and Hälleberg Nyman, Maria}, year = {2025}, url = {2037260}, language = {swe}, publisher = {Natur och kultur} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tryggvasonsgeir_2025_2, title = {Taking on a Critical Approach to Global Justice Issues Teaching : Perspectives from Swedish Teachers}, author = {Tryggvason, Ásgeir and Sund, Louise and Pashby, Karen}, year = {2025}, journal = {Nordisk tidsskrift for pedagogikk og kritikk}, volume = {11}, number = {1}, pages = {209--225}, doi = {10.23865/ntpk.v11.6348}, url = {1967421}, language = {eng}, publisher = {Cappelen Damm Akademisk}, keywords = {global justice issues; teaching; decolonial perspectives; teachers}, abstract = {This article aims to identify and shed light on areas of possibility and barriers for teachers who want to take on a critical approach to global justice issues (GJI). Fifteen upper secondary school teachers from four schools in Sweden participated in focus groups and discussions during a workshop on decolonial and critical approaches to teaching GJI to explore possibilities and challenges. Participants understand critical approaches as those that challenge mainstream perspectives and see this as both difficult and necessary. They express that there are plenty of opportunities and support to take such an approach in the existing curriculum but also note school-level challenges such as a crowded curriculum and assessment-focused culture. Participants find it difficult to engage the current generation of students in recognising and interrogating mainstream approaches and also in linking local and global responsibilities and concerns whereby GJIs can feel either “too close” or “too far away.” Yet, these teachers are highly motivated to take up the challenge and innovate their teaching accordingly. The research contributes to understanding the possibilities and potential foreclosures regarding how teachers approach GJIs in their classrooms. Overall, our research highlights the need to support, develop and sustain reflexive approaches.}, file = {https://oru.diva-portal.org/smash/get/diva2:1967421/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hammarberganders_2025, title = {Talar neck and body fractures : An observational cohort study originating from the Swedish Fracture Register}, author = {Hammarberg, Anders and Rubenson, Anna and Fischer, Per and Wenger, Daniel and Wolf, Olof and Juto, Hans and Möller, Michael and Mukka, Sebastian and Sundkvist, Jonas}, year = {2025}, journal = {Foot and Ankle Surgery}, doi = {10.1016/j.fas.2025.12.007}, url = {2025921}, language = {eng}, publisher = {Elsevier}, keywords = {fracture; talar body; talar neck; talus; trauma}, abstract = {BACKGROUND: This study sought to characterize a cohort of talar neck and body fractures, focusing on fracture characteristics, associated injuries, treatment and outcome.METHODS: We reviewed adult patients registered in the Swedish Fracture Register 2011-2021 with talar neck and body fractures. A minimum 2-year follow-up was conducted for treatment outcomes.RESULTS: We included 313 patients (318 fractures, median age 34 years, 67 % men) of which 106 involved the neck, 134 the body and 78 combined body and neck. 36 % had associated injuries. Operative treatment was implemented for 55 neck (52 %), 81 body (60 %), and 70 combined fractures (90 %). Reoperation rates were, 35 % for neck, 32 % for body and 44 % for combined fractures.CONCLUSION: Talar fractures primarily occur in men and are associated with other fractures. A majority of the fractures are treated operatively and one in three patients undergoes reoperation, with higher reoperation rates in combined body and neck fractures.}, issn = {1268-7731} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssondahlnichelle_2025_1, title = {Talk, tunes and PR : Constructing the Swedish folk music genre through concert practices}, author = {Johansson Dahl, Nichelle}, year = {2025}, url = {2013680}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_maasadriana_2025, title = {Targeted ferroptosis induction enhances chemotherapy efficacy in chemoresistant neuroblastoma}, author = {Mañas, Adriana and Seger, Alexandra and Adamska, Aleksandra and Smyrilli, Kyriaki and Siaw, Joachim T. and Radke, Katarzyna and Muciño-Olmos, Erick A. and Bedoya Reina, Oscar C. and Esfandyari, Javanshir and Aaltonen, Kristina and Bexell, Daniel}, year = {2025}, journal = {npj Precision Oncology}, volume = {9}, number = {1}, doi = {10.1038/s41698-025-01090-6}, url = {1998484}, language = {eng}, publisher = {Springer Nature}, abstract = {Neuroblastoma (NB) is an aggressive pediatric solid tumor which often develops chemoresistance. Ferroptosis is a potential vulnerability in NB, but its interplay with chemoresistance and standard-of-care chemotherapy is not known. Here, we report that key antioxidant pathways are enriched in refractory NB, and that ferroptosis can be induced in NB through various mechanisms of action (MOA) in vitro and in vivo. We observed that NB standard-of-care chemotherapy can interfere with certain ferroptosis-inducing mechanisms, particularly those targeting GPX4, and that the combination of ferroptosis-inducing drugs with current clinical therapy should be based on MOA. Our work also shows that a combination of chemotherapy and the thioredoxin reductase inhibitor Auranofin counteracted some of the anti-ferroptotic effects of chemotherapy and the combination outperformed chemotherapy alone, resulting in increased survival in a chemoresistant NB patient-derived xenograft model. The combination of Auranofin and chemotherapy decreased the population of immature mesenchymal-like NB cells in vivo and exerted its effect through ferritinophagy, lysosome accumulation and iron overload. Thus, upon careful selection of the MOA, the inclusion of ferroptosis-inducing agents within a clinically relevant treatment protocol is feasible and can outperform standard-of-care chemotherapy in high-risk NB.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dalileb_2025, title = {Targeting cognitive resilience through prebiotics : A focused perspective}, author = {Dalile, B. and Boyle, N. B. and Ruiz, F. T. and Chakrabarti, A. and Respondek, F. and Dodd, G. F. and Kadosh, K. Cohen and Hepsomali, P. and Brummer, Robert Jan and McArthur, S. and Dam, V. and Zanzer, Y. C. and Vermeiren, Y. and Schellekens, H.}, year = {2025}, journal = {Advances in nutrition (Bethesda, Md.)}, volume = {16}, number = {1}, doi = {10.1016/j.advnut.2024.100343}, url = {1914057}, language = {eng}, publisher = {Oxford University Press}, keywords = {prebiotics; cognition; cognitive resilience; gut microbiota; gut-brain axis; nutritional interventions; sedentary behaviour; sleep; stress}, abstract = {This perspective article is a product of the work of an expert group within the Prebiotic Task Force convened by the International Life Sciences Institute Europe (ILSI Europe), a non-profit organization that brings together experts from academia, industry and public service to catalyse nutrition science for public benefit. An expert group was conceived in October 2023 to discuss the evidence base on the use of prebiotics to promote cognitive functioning, with a focus on highlighting knowledge gaps and proposing a list of recommendations to guide this specific area of research forward. To address this, we evaluated existing systematic reviews and meta-analyses of human intervention studies that examine the effects of prebiotics on cognitive functioning. These are predominantly conducted in healthy participants under basal conditions and have, to date, revealed limited effects. In this perspective, we propose that prebiotics should be investigated as agents to promote cognitive resilience by testing their effects on cognitive performance under certain cognition-taxing factors that individuals encounter across their lifespan. These include stress, poor sleep outcomes, sedentary behaviour, and unhealthy dietary patterns, all of which have been shown to be associated with altered microbiome and impact global cognition or specific cognitive domains. In addition, we recommend identifying vulnerable populations that are either sub-clinical or that struggle chronically or periodically with one or more cognition-taxing factors, to better uncover the boundary conditions for prebiotic effectiveness. By broadening the scope of research to include diverse populations and challenging conditions in daily life or experimental settings, we can expand our understanding of the role of prebiotics not only in cognitive health or impairment, but also as potential preventative agents that may promote cognitive resilience during aging and in response to various lifestyle-related challenges.}, issn = {2161-8313} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_koskinenjeanette_2025, title = {Teachers as linguistic role models : Language teaching in multilingual ECEC settings}, author = {Koskinen, Jeanette and Karlsson, Josefine}, year = {2025}, journal = {Journal of Early Childhood Education Research}, volume = {14}, number = {2}, pages = {140--168}, doi = {10.58955/jecer.147607}, url = {2018520}, language = {eng}, publisher = {Association for Finnish Early Childhood Education}, keywords = {early childhood education and care; language teaching; multilingualism; linguistic role model; ecec teachers}, abstract = {This article examines ECEC teachers' beliefs about being linguistic role models and how these beliefs relate to their language teaching for multilingual children. Due to the increased language diversity in Finland, the demands on teachers have increased. Teachers are expected to be linguistic role models and create multilingual learning opportunities for all children. This study uses quantitative methods to examine the relationships between teachers as linguistic role models and language teaching for multilingual children. A questionnaire was answered by 42 ECEC teachers in Swedish-medium settings in Finland. Data was analyzed using chi-square tests to depict relationships between variables. Results show that teachers largely agree to be linguistic role models. This correlates with seeing adult-led play as important for language development and using dialogic reading as a teaching strategy. Play with peers was highly valued as a language development activity but not related to being a linguistic role model. Although planning reading activities was considered important, it was not related to being a linguistic role model. The latter may indicate that teachers need more knowledge on how these daily activities can become high-quality language teaching situations, especially when developing children’s academic language skills.}, file = {https://oru.diva-portal.org/smash/get/diva2:2018520/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hultmanannicalfdahl_2025, title = {Teachers' Facebook rebellion groups : sites for professional collegial deliberation?}, author = {Hultman, Annica Löfdahl and Bergh, Andreas}, year = {2025}, journal = {Educational review (Birmingham)}, volume = {77}, number = {6}, pages = {1815--1830}, doi = {10.1080/00131911.2024.2362187}, url = {1885549}, language = {eng}, publisher = {Routledge}, keywords = {teachers; facebook rebellion groups; curriculum theory; deliberative communication; teachers' collective professionalism}, abstract = {This study examines conversations in a Swedish teachers' School Rebellion (SR) group on Facebook, a group that attracts members who wish to engage in activism for a different and better Swedish school system and improved conditions for teachers. The phenomenon of teachers' Rebellion Facebook groups is relatively new. It has emerged in several countries over the past decade and clearly differs from traditional online teacher collaboration and professional development groups. Placing the Swedish SR initiative in the context of discussions on changing teacher professionalism over the last decade, the aim of this study is to examine what content is given presence in SR posts and how it is discussed by members, and to determine the extent to which the communication between the participating teachers has the potential to strengthen collective professionalism. To this end, curriculum theory and the concept of deliberative communication are combined to address questions of content and various relations between actors and levels, such as power and responsibility issues. The analysis shows that many topics related to teaching and education appear in the conversations, deliberative approaches vary from what is termed pre-deliberative to deliberative and even counter-deliberative. Although all participants have a voice, the administrators' role is shown to be of special interest. Based on these findings, the administrators' responsibility to maintain professional collegial deliberation is discussed as a complex mission of deliberation over political, pedagogical, and practical issues.}, issn = {0013-1911}, file = {https://oru.diva-portal.org/smash/get/diva2:1885549/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ojalamaria_2025, title = {Teaching controversial sustainability issues at the junior high-school level : an explorative study of teaching traditions and associations with ways of teaching}, author = {Ojala, Maria and Östman, Leif and Van Poeck, Katrien and Bengtsson, Stefan and Håkansson, Michael and Hansson, Petra}, year = {2025}, journal = {Environmental Education Research}, pages = {1--22}, doi = {10.1080/13504622.2025.2538031}, url = {1986363}, language = {eng}, publisher = {Routledge}, keywords = {ese; education for sustainable development (esd); controversial sustainability issues; teaching traditions; teaching practices}, abstract = {Education about controversial sustainability issues is vital for society’s ability to handle problems like climate change in a democratic manner. How teachers educate about these issues should, ideally, be evidence-based. However, teachers’ ideals and attitudes about education also play a role in how they teach. The aim of this questionnaire study with Swedish junior high-school teachers’ (n=378) was to explore whether, and how, different teaching traditions – culturally shared ideals regarding education – are associated with reported ways of teaching – i.e., various concrete teaching practices – regarding controversial sustainability issues. Four teaching traditions were identified: A fact-based, - against values tradition was negatively related to, while a pluralistic tradition was positively related to, all ways of teaching, i.e., encouraging sustainable actions, rational reflection, perspective-taking, emotional awareness, and using conflicts for learning among students. A fact-based science orientation was foremost positively associated with promoting rational reflection among students. A normative tradition was positively related to encouraging rational reflection, perspective-taking, and emotional awareness. We also investigated differences between teaching traditions regarding gender and subject identification. We discuss the results in relation to theories and earlier studies about teaching traditions. Practical implications for teacher education and already-active teachers are elaborated upon.}, issn = {1350-4622}, file = {https://oru.diva-portal.org/smash/get/diva2:1986363/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_warnickecamilla_2025, title = {Team interpreting in remote settings}, author = {Warnicke, Camilla}, year = {2025}, url = {1996713}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_berglezpeter_2025_3, title = {Ten news value criteria for sustainable journalism}, author = {Berglez, Peter}, year = {2025}, journal = {Journal of Applied Journalism and Media Studies}, volume = {14}, number = {1}, pages = {73--81}, doi = {10.1386/ajms_00105_1}, url = {1742877}, language = {eng}, publisher = {Intellect Ltd.}, keywords = {media; news; agenda 2030; journalism; sdgs; sustainable development}, abstract = {This article argues that journalism scholars and practitioners worldwide should not view 2030, i.e. the year in which the UN Agenda sustainable development goals are to be fulfilled, as a symbolic date, but instead as a real deadline. Such a posture could spur discussion about what more the media could do in these remaining years to promote sustainable development, as well as concrete action. To normatively support such a process in this context, the purpose of this contribution is to suggest news value criteria tailored to manage the challenges of sustainable development. They presuppose a well-functioning relationship between the media’s business and planetary needs. The former concern how to finance journalism and attract audiences/users, while the latter concern what kind of journalism a sustainable world de facto requires. The proposed news value criteria could serve as a point of departure for the development of sustainability-oriented news, which could be jointly tested and configurated by scholars and practitioners.}, issn = {2001-0818} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hellgrenkarljohan_2025, title = {Ten years of visual field change in people living with diabetes : A prospective longitudinal study}, author = {Hellgren, Karl-Johan and Bengtsson, Boel}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {3}, doi = {10.1371/journal.pone.0320285}, url = {1947482}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {BACKGROUND: A better characterization of diabetic retinopathy (DR) may be helpful to monitor early disease, predict progression of DR, and to evaluate new treatment strategies. Visual function has been suggested to complement the assessment of microvascular lesions in DR but needs to be evaluated in longitudinal studies. OBJECTIVES: This prospective longitudinal cohort study investigated whether early visual field deterioration in diabetes is associated with change in DR, and whether known risk factors as diabetes duration and glycated A1c (HbA1c) affect the visual field.METHODS: People living with diabetes, 18 to 75 years of age, were consecutively recruited from the local DR screening program. Individuals with eye diseases other than DR that could affect the visual field, and those who had received previous local eye treatment for DR, could not be included. Participants who had completed a five-year follow-up were re-examined after nine and ten years from baseline. The most important outcome was deterioration in series of visual fields as determined by an experimental model tailored for people living with diabetes. Stages of DR were evaluated according to the Early Treatment Diabetic Retinopathy Study (ETDRS) scale, and glycemic control by measurement of HbA1c.RESULTS: Fifty-six participants (median age 69 years at the last visit, 35 males) completed 608 out of 616 scheduled visits during ten years of follow-up. Progression and regression of DR occurred most often between no (ETDRS level 10) and minimal (ETDRS level 20) DR. The number of deteriorated test points increased annually by 11% (95% CI: 6.9-15.3) and were not associated with change in DR but with higher levels of HbA1c.CONCLUSIONS: Early deterioration of visual function occurred independently of DR and was associated with worse glycemic control, suggesting that the metabolic disturbances due to diabetes induced a primary deterioration of sensitivity in the visual field.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindgrenmonica_2025, title = {Tensions and vulnerabilities in projectified selves : Exploring gender and projectification in neoliberal academic cultures}, author = {Lindgren, Monica and Packendorff, Johann and Berglund, Karin}, year = {2025}, journal = {Scandinavian Journal of Management}, volume = {41}, number = {2}, doi = {10.1016/j.scaman.2025.101402}, url = {1941203}, language = {eng}, publisher = {Elsevier}, keywords = {projectified self; gender; academic organisations; vulnerability; personal worth; careers; projectification; subject position}, abstract = {In this article, we explore the multiple facets of academic projectified selves, i.e. how academics relate to the culture of projectification in neoliberal society, crafting themselves and their careers. We focus our inquiry on the highly gendered character of projectified selves and uncover differences in how the subject position of the projectified self is invoked in academic work, as well as the tensions inherent in such identity work. Through a qualitative interview study involving senior lecturers, both women and men, in a social science discipline across five Swedish universities, we identify three variations of the academic projectified self. We find that they navigate tensions between individual liberties and organisational limitations; that they experience recognition as transitory and unreliable; and that attachment to work is often located in ‘micro-spaces’ rather than in work as a whole. The analysis emphasises the vulnerability of the academic projectified self – in constant need of achievements, projects, and reputation-building initiatives – and how projectification perpetuates gendered inequalities. The article concludes with a discussion on how the notion of the projectified self can be employed in future emancipatory project studies.}, issn = {0956-5221} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_schenklinda_2025_1, title = {Tensions influencing the risk management of hexavalent chromium exposure at Swedish workplaces : evidence from the SafeChrom project}, author = {Schenk, Linda and Engfeldt, Malin and Ricklund, Niklas and Tinnerberg, Hakan and Tondel, Martin and Wiebert, Pernilla and Broberg, Karin and Albin, Maria}, year = {2025}, journal = {Safety Science}, volume = {191}, doi = {10.1016/j.ssci.2025.106953}, url = {1991812}, language = {eng}, publisher = {Elsevier}, keywords = {risk management; hexavalent chromium; occupational exposure limit values; eu reach; carcinogens; mutagens and reprotoxic substances directive; alarp}, abstract = {In this study we investigate risk management trade-offs by evaluating how key persons at workplaces with a potential for exposure to hexavalent chromium (Cr(VI)) reason about what is practically possible in terms of exposure reduction. While the included companies (N = 14) represented different types of processes and worktasks, interviewees all identified that many types of hazards compete for attention at the workplaces, making systematic work environment management a complex undertaking. Risk management efforts are directed by internal and external demands, and the hazard of Cr(VI) was in these cases often overshadowed by other workplace hazards. Interviewees described the overarching aim of continuous improvement, however, zero exposure was not feasible given that the production yielding the Cr(VI) exposure was found a fixed prerequisite or to have other beneficial values (for instance promoting environmental sustainability). What constitutes an exposure at a level that is as low as reasonably practicable was not easily identifiable by interviewees. There were various sources of demands on risk management, legal and corporate but also more personal or moral. Interviewees perceived Occupational Exposure Limits (OELs) as a clear line for unacceptable exposures, however, variability and how it influences compliance were challenging concepts. The socio-economic aspect of Swedish OELs was generally not raised. We conclude that reasonably practicable is a difficult concept, likely leading to wide variability in health risk across workplaces. We recommend explicit policies on acceptable risk levels for OELs for non-threshold carcinogens as they clarify the socio-economic compromise underlying such OELs.}, issn = {0925-7535} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sundbommagnus_2025, title = {Ten-year Results After Primary Gastric Bypass : Real-world Data from A Swedish Nationwide Registry}, author = {Sundbom, Magnus and Näslund, Erik and Ottosson, Johan and Olbers, Torsten and Hedberg, Suzanne and Wennerlund, Jeff and Laurenius, Anna and Stenberg, Erik}, year = {2025}, journal = {Annals of Surgery}, doi = {10.1097/SLA.0000000000006743}, url = {1956064}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, keywords = {diabetes; long-term; metabolic bariatric surgery; obesity; results}, abstract = {OBJECTIVE: To determine the 10-year outcomes regarding weight loss and remission of obesity-related diseases after primary Roux-en-Y gastric bypass (RYGB), when performed in routine clinical care.SUMMARY OF BACKGROUND DATA: Long-term results of metabolic bariatric surgery (MBS) are important, as the number of patients needing help with this chronic condition is increasing globally. However, results from larger nation-wide studies are lacking.METHODS: Cohort study of RYGB-patients from the Scandinavian Obesity Surgery Registry (SOReg), a national Swedish quality registry of MBS. Supplementary data was obtained from the Prescribed Drug Register (pharmacological therapy) and the National Diabetes Register (clinical data). Weight loss, complete remission of comorbidities (defined as no pharmacological therapy and normal laboratory values), and associations for new-onset disease were studied.RESULTS: 29,578 individuals (mean age 41.0±11.0 y, 75.6% females) had a RYGB in Sweden 2007-2012. At ten years, mean body weight was reduced from 112.7 kg to 91.4 kg, corresponding to a total body weight loss of 24.6%. A significant complete remission rate persisted in type 2 diabetes (29.7%), hypertension (15.1%) and dyslipidemia (8.8%), while the use of antidepressants increased by 38.6%, P<0.001 for all. The use of continuous positive airway pressure for sleep apnea decreased from 9.8% to 4.1%. New-onset disease was in general associated to age, low weight loss and presence of other comorbidities.CONCLUSIONS: At ten years, patients undergoing primary RYGB in Sweden demonstrate lasting weight loss and substantial remission of obesity-related diseases. RYGB is a valuable treatment option in the long-term for patients with severe obesity.}, issn = {0003-4932} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_qandeelmais_2025_6, title = {Territorial Annexation of Palestine : Illegality, Third States Obligations and the ICJ’s 2024 Advisory Opinion}, author = {Qandeel, Mais}, year = {2025}, journal = {EJIL:Talk! Blog of the European Journal of International Law}, url = {1941301}, language = {eng}, publisher = {Oxford University Press}, keywords = {annexation; palestine; icj’s 2024 advisory opinion; third states obligations}, abstract = {Territorial annexation by force, whether takes the form of de facto or de jure, is unlawful. In its 2024 Advisory Opinion on Legal Consequences arising from the Policies and Practices of Israel in the Occupied Palestinian Territory (oPt), including East Jerusalem, the ICJ affirmed that both de facto annexation and du jure annexation of the oPt are equally unlawful. This blogpost discusses Israel’s plan to assert its sovereignty over and annex the oPt and the obligation of third states not to recognize such annexation in the light of the ICJ’s 2024 Advisory Opinion.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_dokim_2025, title = {Tetracycline-resistant Neisseria gonorrhoeae global estimates-impacts on doxycycline post-exposure prophylaxis implementation and monitoring : a systematic review}, author = {Do, Kim and Unemo, Magnus and Kenyon, Chris and Hocking, Jane S. and Kong, Fabian Yuh Shiong}, year = {2025}, journal = {JAC - Antimicrobial Resistance}, volume = {7}, number = {4}, doi = {10.1093/jacamr/dlaf120}, url = {1983529}, language = {eng}, publisher = {Oxford University Press}, abstract = {OBJECTIVES: Doxycycline post-exposure prophylaxis (doxyPEP) can reduce incident sexually transmitted infections including gonorrhoea for MSM and transgender women. Its effectiveness depends on the level of tetracycline resistance in Neisseria gonorrhoeae, which varies by country. Countries implementing doxyPEP should have robust antimicrobial resistance (AMR) surveillance using standardized, quality-assured methods. This systematic review estimates the proportion of tetracycline-resistant N. gonorrhoeae isolates by country/region and describes the contribution of sex and infection site to these estimates.METHODS: We searched bibliographic databases (1 January 2000 to 26 August 2024) for English-language studies reporting tetracycline MIC with a sample size of >10 isolates. Data on country, year, sex, sexual orientation and infection site were collected. Countries were grouped into seven World Bank regions. Tetracycline resistance (MIC > 1 mg/L) was reported by country, region and time period (2010-23 versus 1996-2009).RESULTS: Sixty-seven included studies from 51 countries studying 80 645 isolates (91% from 2010-23) were analysed. Overall median tetracycline resistance was 54.2% (range 4.0%-100.0%). Highest resistance occurred in East Asia and Pacific (82.1%, 18%-100%) and sub-Saharan Africa (81.6%, 44%-100%), and lowest in North America (26.5%, 4%-78%). Only 16% (11/67) of studies reported MSM, 18% (12/67) included oropharyngeal isolates and 9% (6/67) included women. Resistance increased by 3-4-fold in South Asia [relative risk (RR) 3.8] and North America (RR 4.1) over time.CONCLUSIONS: High and rising tetracycline resistance limits doxyPEP's potential to prevent gonorrhoea. More data are needed from MSM, women and oropharyngeal sites to understand AMR trends and transmission dynamics between MSM and women.} } @book{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrkvallanders_2025_6, title = {Text i arbete : Handbok för analys av professionella praktiker}, author = {Björkvall, Anders and Nystöm Höög, Catharina}, year = {2025}, url = {1963249}, language = {swe}, publisher = {Studentlitteratur AB}, keywords = {professionella texter; genre; professionell praktik; arbetsliv; värdegrund; diskurs; legitimering}, abstract = {En stor del av dagens arbetsliv handlar om att hantera texter av olika slag. Det kan gälla allt från lappar i köket och instruktioner på brandvarnare i kapprummet till jobbannonser från företag, utvärderingsenkäter på universitet och värdegrundstexter hos kommuner och myndigheter. En av huvudpoängerna i den här boken är att texter gör något, att de faktiskt utför ett arbete.Författarna beskriver vilken professionell handling som utförs med hjälp av olika texter och hur texter är en del av en professionell praktik, det vill säga ett särskilt sätt att göra saker på en viss arbetsplats. Med belysande exempel förklarar de grundläggande analysbegrepp som genre, diskurs och legitimering samt presenterar verktyg som läsaren kan använda för att själv analysera texter och praktiker på arbetsplatsen.Boken vänder sig till studenter och yrkesverksamma som vill veta mer om vad texter gör och varför de finns i olika sammanhang i arbetslivet. Den fungerar lika bra på grundnivå inom språk- och kommunikationsvetenskapliga utbildningar som på bredare samhällsvetenskapliga utbildningar.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_wurmmatilda_2025_1, title = {TGD people with comorbid pain and emotional problems : a replicated single case study}, author = {Wurm, Matilda and Norberg, Emma and Stålfors, Clara and Malmquist, Anna and Tove, Lundberg and Ekholm, Elin}, year = {2025}, url = {2041490}, language = {eng}, keywords = {transgender and gender diverse; comorbidity; chronic pain; sced}, abstract = {Studies show that transgender and gender diverse (TGD) people have a higher risk of ill health than cisgendered people due to the higher risk for exposure. Physical ill health has been studied to a lesser degree than mental ill health, but studies indicate that pain problems may also be more prevalent in TGD people. This confirms previous research showing that comorbidity between mental ill health and pain problems are common. The current study aimed to explore whether a trans-affirmative intervention could alleviate functional impairment associated with pain, depression, and anxiety using a replicated single case design where measurements during baseline for each individual are compared to measurements during treatment. The intervention consisted of three distinct modules focusing on: minority stress/minority joy, worry, and self-compassion. Of the participants enrolled in the intervention study who reported some health problems, about a quarter (N= 8) reported musculoskeletal pain every week as well as comorbid depression and/or anxiety. Participants provided weekly ratings over a period of 21 to 24 weeks. Results show a decrease in impairment on depression and anxiety for four and five participants respectively, with mean-size NAP scores (Nonoverlap of All Pairs, a statistical measure commonly used in single case designs). Despite pain problems not being specifically targeted in the intervention, NAP scores also showed medium effect sizes on pain functioning for six of the eight participants. Results show that the intervention may be helpful, which should be explored in future studies.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_colemichelle_2025, title = {The Ability of European Economic Area Countries to Respond to the Threat of Multi-Drug Resistant Neisseria Gonorrhoeae Has Weakened}, author = {Cole, Michelle and van Rensburg, Melissa Jansen and Jacobsson, Susanne and Alexander, Sarah and Ködmön, Csaba and Unemo, Magnus}, year = {2025}, journal = {Sexual Health}, volume = {22}, number = {4}, pages = {371--371}, url = {2037912}, language = {eng}, publisher = {CSIRO Publishing}, abstract = {Background: The European Centre for Disease Prevention and Control response plan to control and manage the threat of multi- and extensively drug-resistant Neisseria gonorrhoeae (MDR/XDR-NG) was updated and published in 2019. The effectiveness and value of the response plan is assessed periodically to identify and address areas for improvement.Methods: During 2024, EU/EEA countries were invited to provide information on the response plan indicators for 2023, using 2019 as a baseline. The indicators assessed a country’s ability to perform gonococcal antimicrobial surveillance and to clinically manage gonorrhoea, including treatment failure monitoring. Additionally, indicators assessing the European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) were completed.Results: All 30 countries responded, however only 24 countries participated in the Euro-GASP surveillance in 2023, two less than 2019. Similarly, 24 laboratories participated in the 2023 EQA, 13 fewer than in 2019. In contrast, increasing numbers of gonococcal isolates were submitted to Euro-GASP; 5,269 vs 4,166 isolates in 2019, representing a 27% increase.There was a lower proportion of STI clinics with access to antimicrobial susceptibility testing (AST) and culture; 97% in 2019 vs 83% in 2023. Also, the proportion of gonorrhoea cases with AST decreased by 9%, as well a 15% decrease in patients receiving appropriate treatment.There was little change in the reporting and completeness of Euro-GASP epidemiological variables, as well as treatment failure monitoring.Conclusion: Euro-GASP, like many other programmes and services, faced unprecedented circumstances in 2019–2021 due to COVID-19. We may still experience the impact of this pandemic, as the ability to respond to MDR/XDR-NG seems to have weakened in the EU/EEA. This is concerning as we are currently observing increases in gonorrhoea cases, as well as cases of MDR/XDR NG in Europe. Renewed efforts to go back to basics, to improve obtaining cultures and linked patient metadata, are now underway.}, issn = {1448-5028} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_liljedahlprytzkarolina_2025, title = {The Ability of NEWS2 to Detect Sepsis in Adult Patients With Positive Blood Cultures}, author = {Liljedahl Prytz, Karolina and Magnuson, Anders and Sundqvist, Martin and Kurland, Lisa and Källman, Jan}, year = {2025}, journal = {Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)}, volume = {133}, number = {12}, doi = {10.1111/apm.70129}, url = {2024479}, language = {eng}, publisher = {Munksgaard Forlag}, keywords = {bsi; news2; sofa; community‐acquired; emergency department; sepsis}, abstract = {Blood stream infections are associated with high mortality and morbidity. NEWS2 is a quick scoring system including bedside measurable vital signs. This study aimed to investigate the ability of NEWS2 ≥ 5p to identify sepsis, per Sepsis-3 criteria, among adult patients with community-acquired infection and positive blood cultures. It also explored if NEWS2 ≥ 5p could indicate infection etiology based on bacterial species in blood culture. This retrospective study included 555 patients with positive blood cultures. 425 of 555 (76.6%) patients had sepsis. The sensitivity of NEWS2 ≥ 5p for detecting sepsis was 86.6% and was not statistically associated with infection etiology. Patients with S. pneumoniae had a higher median NEWS2 score than those with other bacterial species. The 28-day mortality rate was 12.1%, and the sensitivity of NEWS2 ≥ 5p for detecting 28-day mortality was 91.0%. NEWS2 ≥ 5p was detected in a high proportion of sepsis cases among patients with blood stream infections, independent of bacterial species, and is a quick tool for identifying high sepsis likelihood in the emergency department.}, issn = {0903-4641} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kuhlinfanny_2025, title = {The abuse narrative in sport : the findings of a framework synthesis literature review}, author = {Kuhlin, Fanny and Barker-Ruchti, Natalie}, year = {2025}, journal = {Qualitative Research in Sport, Exercise and Health}, volume = {17}, number = {5}, pages = {382--400}, doi = {10.1080/2159676x.2025.2487700}, url = {1953078}, language = {eng}, publisher = {Routledge}, keywords = {athletes; stories of abuse; silencing; arthur frank; qualitative research}, abstract = {In recent years, athletes from around the globe have taken to social and traditional media to share their stories of abuse in sport. Their stories include a love for a sport and dream to become successful, a getting used to and enduring abusive coaching and training methods, and later in life, recognising that their experiences were abusive. The purpose of this article was to explore the abuse narrative in sport by conducting a framework synthesis literature review. A narrative sociological framework informed by Arthur Frank conceptualised the abuse narrative in sport as a process that shapes lives. The descriptive results reveal that scholars predominantly research abuse while athletes are in sport. The thematic results demonstrate that the abuse narrative constitutes three phases, through which athletes get to know the abuse narrative (normalisation), accept and cope with the abuse (embodying), and possibly later in life, recognise that their experiences were abusive (interruption). Importantly, our Frankian interpretations reveal that the abuse narrative silences athletes and prevents them from recognising abuse. Later in life, stories of abuse in sport, told by others, are powerful resources that can interrupt individuals' abuse narrative in sport. While new to qualitative sport sciences, the framework synthesis review method has potential for researching sensitive topics.}, issn = {2159-676X} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_norlingmartina_2025, title = {The affordances of a particular form of read-aloud for toddlers}, author = {Norling, Martina and Simonsson, Maria and Pramling, Niklas}, year = {2025}, pages = {282--282}, url = {2006746}, language = {eng}, keywords = {ecec settings; educare; read aloud; toddlers; affordances}, abstract = {This study examines a phenomenon that appears to be unexplored in previous research on reading aloud to toddlers in ECEC: “waking up to a book." Research builds on previous studies emphasizing the potential of children's books and reading aloud for teaching and research highlighting read aloud practices associated with the period after sleeping time in ECEC settings (Grunditzs, 2013). Theoretically, the study adopts a sociocultural perspective on communication and learning (Säljö, 2010; Linell, 2009), and affordance theory (Gibson, 1979) to analyze what opportunities, engagement, and care that are offered. The study has a qualitative approach. Data consist of video recorded read aloud sequences (N=4,5 h). The transcribed sequences serve as the foundation for analysis of affordances. The project has been approved by the Swedish Ethical Review Authority. The ECEC participants and the children's parents have been informed and have given their consent to participate in accordance with ethical considerations of confidentiality (Swedish Research Council, 2024). We have applied the ethical code for EC researchers (Bertram et al., 2024). Consideration has been given to any indications from participants expressing not to be video recorded. Results indicate that the reading aloud practices of 'waking up to a book,' are characterized by flexibility and situation-specific goal orientation, where a holistic approach to being responsive to the children's needs and supporting their participation is central. Findings contribute knowledge on how a previously unexplored form of read aloud can function as an educational resource to support toddlers’ interest in books and reading together with peers. } } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_erikssonmats_2025_5, title = {The agreement between parent and child-reported measures of somatic distress, gastrointestinal symptoms, mental health and self-rated health, in girls 9-13 years old with functional abdominal pain}, author = {Eriksson, Mats and Duberg, Anna and Philipson, Anna}, year = {2025}, url = {1973902}, language = {eng}, keywords = {girls; pain; agreement}, abstract = {Aim and hypothesis To explore the agreement between parentand child reported measures of somaticdistress, gastrointestinal symptoms, mentalhealth and self-rated health, in girls 9-13years old with functional abdominal pain.Methods Secondary analysis of data from aprospective randomized controlled trialcalled the Just in TIME study (1, 2), on girlsaged 9–13 years with FunctionalAbdominal Pain Disorders (FAPDs). Weanalyzed data from instruments that bothgirls and their legal guardians answeredseparately, at study start: Childrenssomatization inventory - gastrointestinaldistress (CSSI-GI) and somatic distress(CSSI-nonGI), Self-rated health (SRH), andMental Health Symptoms (MHS).Results Data from 121 girls (mean age 10.6 years)were analyzed, including 74 with FAPD and47 with Irritated Bowel Syndrom. For CSSI-GIthe girls reported a mean score of 6.98 (SD4.39) and the guardians 7.27 (4.31) with anintraclass correlation (ICC) of 0.84 (p<0.001).Corresponding numbers for CSSI-nonGI were8.75 (6.51) and 6.79 (5.05), ICC 0.75(p<0.001). The weighted Cohen’s kappa was0.32 (p<0.001) for SRH and for the MHS itemsthe kappa varied from 0.20 to 0.52, allsignificant.Discussion The findings reveal good agreement forgastrointestinal and general somaticsymptoms but lower agreement whenreporting mental and general health.Importance Understanding parent-child agreement in self-reported health measures enhances insight intohow symptoms are perceived across informants and contexts. It also informs when and forwhom a child’s self-report may be considered sufficient in clinical or research settings.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_drinii_2025, title = {The analytical view of solution of fractional kinetic equations}, author = {Drin, I. I. and Drin, S. S. and Drin, Y. M.}, year = {2025}, pages = {51--52}, url = {2018728}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vareavaleria_2025, title = {The anatomy of body shaming in sports coaching}, author = {Varea, Valeria and Primus, Robert S. and Barker-Ruchti, Natalie and Quennerstedt, Mikael}, year = {2025}, journal = {Sport in Society: Cultures, Media, Politics, Commerce}, volume = {28}, number = {5}, pages = {722--739}, doi = {10.1080/17430437.2024.2380452}, url = {1887056}, language = {eng}, publisher = {Taylor & Francis}, keywords = {body shaming; body criticality; body sensitivity; coaching; elite athletes}, abstract = {Stories of body shaming in sports coaching are becoming widespread, and can intentionally, unintentionally, or inadvertently be used in different sports coaching practices. These practices do not necessarily intend to harm athletes. The aim of this paper is to explore body critical and body sensitive sport coaching practices that have the potential to be shaming, or as we call it in the title, the ‘anatomy’ of body shaming. The study used photo elicitation interviews including vignettes for data generation with 12 coaches from nine different sports. The results demonstrate that body criticality and body sensitivity function in different subtle ways and that coaches were well-aware of the potentially damaging influence that they can have on athletes. The article concludes with recommendations for further research exploring how athletes experience the most subtle and invisible ways of body critical and body sensitive practices, and how they internalize this well-intended but still potentially shaming advice.}, issn = {1743-0437} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_15, title = {The “Anti-Gender Movement,” Capitalism, and the Left}, author = {Johansson Wilén, Evelina}, year = {2025}, journal = {Contemporary Sociology}, volume = {54}, number = {3}, pages = {200--203}, doi = {10.1177/00943061251330131d}, url = {1953985}, language = {eng}, publisher = {Sage Publications}, issn = {0094-3061} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_deboisesam_2025_4, title = {The appeal of musical masculinism within contemporary online far-right spaces}, author = {de Boise, Sam}, year = {2025}, journal = {Journal of Gender Studies}, pages = {1--14}, doi = {10.1080/09589236.2025.2527697}, url = {1985283}, language = {eng}, publisher = {Routledge}, keywords = {masculinism; fashwave; far-right; fascism; masculinity}, abstract = {Music, in different forms, has historically supported far-right movements. Today, however, as a result of digitalization and fragmentation, there are a wide variety of music styles which are both engaged with and used among far-right movements. This article argues that ideas around masculinism are central to music’s appeal in the international, contemporary, English-speaking far-right in a way that spans aesthetic differences. Using extensive user comments from far-right web forums and video-streaming comments under far-right artists, it argues that both the materiality of the sounding aspects and discourses about the music work to shape interpretations of ‘musical masculinism’. The article first explores how ‘feminized’ music is actively discouraged in contemporary far-right spaces. It moves on to examine music’s reception as it links to masculinism as both a consequence of the sounding properties of the music and ideological judgements about it, with a focus on metal and ‘fashwave’ genres. Finally, it explores how masculinist principles even permeate the positive reception of classical music through appeals to harmony as natural order. Through this, it argues that, despite disparate genre preferences, masculinism is an implicitly core tenet which runs through positive and negative evaluations across a range of different musical styles.}, issn = {0958-9236}, file = {https://oru.diva-portal.org/smash/get/diva2:1985283/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bergjohan_2025, title = {The Association between Antenatal SARS-CoV-2 Exposure and Infant Neurodevelopment at Four Months of Age : A Prospective Multicenter Cohort Survey within the COPE Study}, author = {Berg, Johan and Linden, Karolina and Zaigham, Mehreen and Domellöf, Magnus and Ahlsson, Fredrik and Elfvin, Anders and Åden, Ulrika and Abrahamsson, Thomas and Ohlin, Andreas and Berg, Johannna and Hjertberg, Linda and Graner, Sofie and Wendel, Sophia Brismar and Iorizzo, Linda and Arnkil, Sofie and Carlsson, Ylva and Veje, Malin and Bergman, Lina and Sengpiel, Verena and Andersson, Ola}, year = {2025}, journal = {International Journal of Infectious Diseases}, volume = {158}, doi = {10.1016/j.ijid.2025.107973}, url = {1982356}, language = {eng}, publisher = {Elsevier}, keywords = {child development; infant; infectious; neurodevelopmental disorders; pregnancy complications; prenatal exposure delayed effects; sars-cov-2}, abstract = {OBJECTIVES: It remains unclear whether antenatal SARS-CoV-2 exposure affects subsequent infant neurodevelopment. We aimed to investigate the association between antenatal maternal SARS-CoV-2 infection and neurodevelopment in four-month-old infants.METHODS: Data was collected within the prospective multicenter COVID-19 during pregnancy and early childhood study, COPE (NCT04433364). Infants exposed to maternal SARS-CoV-2 infection from conception until two days postpartum and unexposed controls were included June 2020-December 2022.PRIMARY OUTCOME: four-month-old infant neurodevelopment, measured using the Ages and Stages Questionnaire 3rd Edition (ASQ) total mean scores.SECONDARY OUTCOMES: Scores below cutoff for total ASQ or the ASQ domains. RESULTS: Of 2,453 enrolled infants, 1,446 (555 exposed and 891 unexposed) had available ASQ data. In adjusted regression models, there was no group difference in ASQ total mean scores. Exposed infants had lower risk of fine motor domain scores below cutoff (exposed: 4.0% vs. unexposed: 6.6%; adjusted odds ratio (aOR), 0.55; 95% CI, 0.33-0.92). Infants exposed to severe maternal COVID-19 had increased risk of total ASQ scores below cutoff (exposed: 16.0% vs. unexposed: 6.1%; aOR, 3.57; 95% CI, 1.14-11.24).CONCLUSIONS: Antenatal maternal SARS-CoV-2 infection was not associated with overall impaired four-month infant neurodevelopmental screening. In exploratory analyses, severe maternal COVID-19 was associated with abnormal screening results.}, issn = {1201-9712} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kaninaaleksandra_2025_1, title = {The Association Between Clinically Diagnosed Neonatal Jaundice and Autism : A Swedish Register-Based Cohort Study}, author = {Kanina, Aleksandra and Li, Zhou and Rosenqvist, Mina and Butwicka, Agnieszka and Larsson, Henrik and Johansson, Stefan and Radó, Márta K. and Martini, Miriam I. and Taylor, Mark J.}, year = {2025}, journal = {Acta Paediatrica}, volume = {114}, number = {11}, pages = {2925--2934}, doi = {10.1111/apa.70191}, url = {1981415}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {autism; delayed effects; jaundice; prenatal exposure}, abstract = {AIM: Neonatal jaundice may increase the likelihood of autism through its influence on neurodevelopment. We assessed whether neonatal jaundice increases the risk for autism while accounting for confounding of perinatal risk factors.METHOD: We used a population-based cohort of 1 669 830 individuals born in Sweden between 1992 and 2010. Information on jaundice and autism was retrieved from Swedish registers. Participants were followed from the age of 3, with available follow-up until 2013. We used Cox regression to estimate the hazard ratios (HRs) relating autism to neonatal jaundice.RESULTS: Prior to accounting for covariates such as prenatal and perinatal factors, we observed an association between neonatal jaundice and autism (HR = 1.48, 95% CI: 1.37-1.60). This association significantly weakened after adjusting for potential confounders, particularly gestational age and birth weight. After adjusting for all covariates, the association nullified (HR = 1.02, 95% CI: 0.93-1.12).CONCLUSION: The association between neonatal jaundice and autism is confounded, in particular by preterm birth. Our results highlight the importance of accounting for perinatal confounders when investigating the link between early life factors and autism, which may not always be genetic or familial.}, issn = {0803-5253} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lihansen_2025_2, title = {The association between reported artificial light and reported physical activity at night : the mediating roles of environmental restorativeness and perceived safety}, author = {Li, Hansen and Liu, Qian and Yang, Ying and Liu, Liming and Zhang, Guodong and Zhang, Xing and Yin, Mingyue and Cao, Yang and Browning, Matthew H. E. M.}, year = {2025}, journal = {Humanities and Social Sciences Communications}, volume = {12}, number = {1}, doi = {10.1057/s41599-025-05666-2}, url = {1999094}, language = {eng}, publisher = {Palgrave Macmillan}, abstract = {Artificial light at night may facilitate physical activity after sunset. To investigate this possibility, we conducted a survey with 646 Chinese adults to examine the associations between both subjectively and objectively measured artificial light at night and various intensities and domains of nighttime physical activity. We also explored the potential mediating roles of environmental restorativeness and perceived safety in these associations. Data were collected via an online questionnaire based on participants' self-reported information. Through natural language analysis, we identified the reasons participants chose to engage in nighttime physical activity. We applied Spearman-based pairwise and network analyses to examine relationships among the variables, followed by generalized additive models (GAMs) and linear regression to explore potential patterns between artificial light at night and other variables. For associations showing near-linear trends, we conducted mediation analyses using saturated models. Our results revealed that over 70% of participants engaged in nighttime physical activity, mainly due to limited availability during the day. Across all statistical approaches, objective artificial light at night showed no significant association with nighttime physical activity. In contrast, subjective artificial light at night, when rated within a certain range (>= 4), was positively associated with perceived safety, environmental restorativeness, and nighttime physical activity. Within this rating range, environmental restorativeness played a central mediating role, largely explaining the relationship between subjective artificial light at night and all forms of nighttime physical activity. The mediating role of perceived safety was limited. It is important to note that our analyses were based on cross-sectional data and guided by theoretical frameworks; thus, causal relationships among the variables cannot be inferred.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fagermalmerica_2025, title = {The association of sepsis with level of care among older people presenting to the emergency department : A national register study in Sweden}, author = {Fagermalm, Eric A. and Smith, Daniel and Montgomery, Scott and Masarrat, Pooyan and Kurland, Lisa}, year = {2025}, journal = {Journal of Infection and Public Health}, volume = {18}, number = {12}, doi = {10.1016/j.jiph.2025.102942}, url = {1999656}, language = {eng}, publisher = {Elsevier}, keywords = {elderly; level of care; municipal care; risk of sepsis; sepsis}, abstract = {BACKGROUND: Sepsis is potentially fatal and commonly affects older people. However, little is known of the association between surviving sepsis and older patients' autonomy and dependency following hospital discharge.METHODS: A population-based register study using data from five Swedish national registers included emergency department (ED) visits and in-hospital admission of patients aged 65 years of age and older years with infection or sepsis between 2013 and 2020. The consumption of home care services and residential care, as well as mortality, was examined 1, 6 and 12 months after hospital discharge using mixed models. FINDINGS: 166,188 ED visits with sepsis (23 %) and non-sepsis infections (77 %). Sepsis was associated with an increased risk of becoming dependent on home care (RR=1.09 [1.03-1.15]), residential care (RR=1.05 [1.0-1.1]) and mortality (RR=1.96 [1.89-2.03]) 12 months after in-hospital discharge compared to being diagnosed with infection only. The level of care one month prior to the index ED visit, among the study population, i.e., patients having attended the ED with sepsis and infection, was associated with risk of sepsis OR = 1.31 [1.27-1.35] for patients dependent on home care, and OR = 2.16 [2.09-2.23] for patients dependent on residential care as compared to patients independent on home care. INTERPRETATION: The current study suggests that sepsis is a major debilitating condition in older survivors, and many patients do not recover former dependency levels, one year after discharge as well as an increased mortality risk. Also, prior dependency on home care or residential care was a risk factor for sepsis for those patients who attended the ED with sepsis and infection. FUNDING: Funding was obtained through Örebro University, Sweden and the Research Committee of Region Örebro Län, Sweden.}, issn = {1876-0341} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_leijonanna_2025, title = {The BABITT questionnaire for evaluation of bowel and bladder function in children who are introduced to assisted infant toilet training : content validity and feasibility}, author = {Leijon, Anna and Nilsson, Terese and Sillén, Ulla and Hellström, Anna-Lena and Vixner, Linda and Skogman, Barbro Hedin}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {4}, doi = {10.1371/journal.pone.0320564}, url = {1956074}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {Functional bowel and bladder disorders are prevalent among children. In 2019 our research group launched the BABITT study (Bowel and Bladder function in Infant Toilet Training), a randomized intervention study to investigate whether introduction to assisted infant toilet training reduces the prevalence of functional bowel and bladder disorders in children up to 4 years of age. Diagnostic criteria for gastrointestinal disorders are defined by the ROME Foundation, while the International Children’s Continence Society (ICCS) provides definitions of functional bladder disorders. Preceding the larger ongoing BABITT study, the aim of this present observational study is to construct, assess content validity and evaluate feasibility of a questionnaire for parent report.Methods: A web-based questionnaire was developed in three consecutive steps. In Step 1, the questionnaire was outlined based on literature review and expert panel discussions. In Step 2, the questionnaire was validated for relevance and simplicity by content validity index (CVI) using 4-point Likert scales. With dichotomized data, an index level ≥ 0.78 was considered as acceptable. In Step 3, the respondent burden was analysed and a pilot phase allowed for evaluation of feasibility in the clinical study setting.Results: In Step 1, the Rome IV criteria and ICCS frameworks were selected for items comprising the primary outcomes in the BABITT study. After the final assessment round in Step 2, the item-level content validity index (I-CVI) was excellent, ranging from 0.88 to 1.00 in most items, in all domains, for both relevance and simplicity. In the pilot phase Step 3, the response rate was 95% and the parents’ acceptance of replying to the questionnaire was satisfactory.Conclusion: A web-based questionnaire was developed to evaluate parent-reported bladder and bowel function in children who are introduced to assisted infant toilet training. The BABITT questionnaire emerged as valid and feasible in its context.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_geruszvincent_2025, title = {The bactericidal FabI inhibitor Debio 1453 clears antibiotic-resistant Neisseria gonorrhoeae infection in vivo}, author = {Gerusz, Vincent and Regenass, Pierre and Rousseau, Quentin and Moraine, Victor and Dao, Justine and Lavé, Xavier and Das, Shampa and Hue Perron, Josée and Fajas Descamps, Laurence and Bravo, Juan and Dieppois, Guennaëlle and Kaplan, Nachum and Lefebre, Matthew and Altomari, Deanna and Romanov, Vladimir and Finn, Terry and Daram, Pierre and Bernardini, Francesca and Gross, Michaël and Lysek, Robert and Adam, Aurélien and Pohin, Danig and Maio, Maurizio and Tatsis, Vasileios and Sunose, Mihiro and Ronin, Céline and Ciesielski, Fabrice and Ahlstrand, Josefine and Jacobsson, Susanne and Unemo, Magnus and Cameron, David R.}, year = {2025}, journal = {Nature Communications}, volume = {16}, number = {1}, doi = {10.1038/s41467-025-63508-w}, url = {1999646}, language = {eng}, publisher = {Springer Nature}, abstract = {Gonorrhoea is a prevalent sexually transmitted infection caused by the bacterial pathogen Neisseria gonorrhoeae. N. gonorrhoeae has demonstrated a remarkable capacity to evolve antibiotic resistance, with emerging strains that show resistance to all standard treatment options. The development of new antibiotics for gonorrhoea, especially those with novel targets and no pre-existing resistance, is critical. One such untapped antibacterial target in N. gonorrhoeae is FabI, an enoyl-acyl carrier protein reductase enzyme that is essential for fatty acid biosynthesis in this pathogen. In the current report, structure-based drug design using novel N. gonorrhoeae FabI inhibitor co-crystals guides medicinal chemistry toward increasing potency in the sub-nanomolar range and drives the discovery of Debio 1453. Debio 1453 is optimized for activity against N. gonorrhoeae and is highly active in vitro against diverse N. gonorrhoeae isolates including those resistant to the last remaining treatment options. Additionally, the compound presents a low propensity for selection of mutants with reduced susceptibility. Debio 1453 is efficacious in vivo against N. gonorrhoeae isolates with clinically relevant multi-drug resistance phenotypes in a murine vaginal gonorrhoea infection model underscoring Debio 1453 as a promising candidate for the treatment of gonorrhoea.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jnssonmarie_2025_1, title = {The broken care chain-report from a country with a low number of hospital beds}, author = {Jönsson, Marie and Appelros, Peter and Holmefur, Marie and Fredriksson, Carin}, year = {2025}, journal = {Frontiers in Health Services}, volume = {5}, doi = {10.3389/frhs.2025.1632220}, url = {2006262}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {healthcare; healthcare professionals; older adults; phenomenography; readmission; social care}, abstract = {BACKGROUND: Approximately 30% of older adults admitted to hospital in Sweden are readmitted within three months. Short hospital stays and readmission can lead to further functional decline, as recovery appears to be poor at home after discharge.AIM: To explore healthcare professionals' experiences of transitional care in older adults in order to prevent readmission.METHODS: Four focus group interviews were conducted with healthcare professionals (n = 29). Data were analyzed using a phenomenographic approach.RESULTS: Healthcare professionals' perceptions were compiled into seven descriptive categories. Three of the categories, i.e., resources, interprofessional coordination, and advanced care needs can be difficult to meet, described healthcare professionals' perceptions of the current stage of older adults-the first-order perspective, i.e., what something is. The remaining categories described the meanings of the healthcare professionals' perceptions. CONCLUSION: Several interacting structural issues cause readmissions. These include premature discharge from hospital, poor hand-over between healthcare professionals, and a lack of qualified staff in the home-setting. To prevent readmission, medical competence and interprofessional teamwork must be improved in the home setting.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_bergmanrosamondannika_2025, title = {The Case for Interdisciplinary Crisis Studies}, author = {Bergman-Rosamond, Annika and Gammeltoft-Hansen, Thomas and Hamza, Mo and Hearn, Jeff and Ramasar, Vasna and Rydström, Helle}, year = {2025}, pages = {23--48}, url = {2021696}, language = {eng}, publisher = {Bristol University Press} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fustfornfrancesc_2025, title = {The Chef and the Supplier : The Role of the Supply Chain in Fine Dining Creativity}, author = {Fusté-Forné, Francesc and Leer, Jonatan}, year = {2025}, journal = {International Journal of Sociology of Agriculture and Food}, volume = {31}, number = {1}, pages = {1--14}, doi = {10.48416/ijsaf.v31i1.556}, url = {2023359}, language = {eng}, publisher = {CENDES, Universidad Central de Venezuela}, keywords = {demark; food tourism; gastronomy; menu design; michelin; regional development; sustainability}, abstract = {This article studies the relationship between culinary creativity in fine dining restaurants and the supply chain that supports them. Fine dining has experienced a renaissance in recent decades, with chefs pushing the boundaries of culinary innovation. However, little attention has been given to the pivotal role that suppliers play in this creative process. Based on the exploration of four case studies of Michelin-starred restaurants in Denmark, the paper uncovers the ways in which the supply chain influences the dynamics of high-end restaurants, proposing a social-material perspective on culinary creativity. Results show how sourcing practices impact fine dining creativity, and highlight the role of nature and quality as the foundations of the relationships between chefs and suppliers. This research innovatively sheds light on the behind-the-scenes processes that drive fine dining and shows how different restaurants think differently about the role of suppliers in the creative process. The strategies involve more traditional chef-centred approaches to culinary creativity, as well as ambitions to become self-sufficient. Results also show that the restaurants put the farmers first, seeing the supply chain and the food system as central to culinary creativity.  We argue that these approaches seem to be essential to the development of more sustainable forms of Michelin restaurants.}, issn = {0798-1759} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ohaganlaurenalex_2025_8, title = {The colleen and the crafting of Irishness : evolving national identity in McClinton's Colleen Soap advertisements, 1910-1923}, author = {O’Hagan, Lauren Alex}, year = {2025}, journal = {Irish Studies Review}, volume = {33}, number = {3}, pages = {315--344}, doi = {10.1080/09670882.2025.2532382}, url = {1989247}, language = {eng}, publisher = {Routledge}, keywords = {soap; advertisements; colleen; ireland; irishness; civilised whiteness}, abstract = {This article explores how McClinton's Colleen Soap used the figure of the colleen to craft Irishness in its marketing through advertisements in the British and Irish press (1910-1923). Using visual social semiotic analysis, it examines the co-deployment of language, image, colour, typography, layout and composition to articulate and negotiate representations of Irishness and its evolution over time. Ultimately, it reveals the various ways in which Irish identity was self-fashioned and presented to both British and Irish audiences, drawing on contemporary political issues and the concept of "civilised whiteness," thus demonstrating the fluid, fragile and sometimes fictitious nature of national identity. McClinton's Colleen Soap, therefore, serves as a rich case study for examining how Irishness was continuously reinvented, reimagined and remarketed, and how a small Ulster company navigated its relationship with the British Empire during a turbulent period in its history.}, issn = {0967-0882} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_brochlvikjonmikkel_2025, title = {The Complexity of Banality : Neoclassicism and Popular Music in Pauline Hall’s Suite for Wind Quintet}, author = {Broch Ålvik, Jon Mikkel}, year = {2025}, pages = {129--145}, doi = {10.1007/978-3-031-98261-3_7}, url = {2002273}, language = {eng}, publisher = {Palgrave Macmillan}, keywords = {classical music; contemporary music; history of music; popular music; klassisk musik; samtida musik; musikhistoria; populärmusik}, abstract = {This chapter explores Pauline Hall’s Suite for Wind Quintet (1945) as a neoclassical work that exemplifies Neue Sachlichkeit aesthetics through its use of irony, stylistic sobriety, and references to popular music. Drawing on the influence of French and German modernism, Hall blends classical forms with elements from popular dance and film music, challenging the boundary between high and low art. Particular attention is given to the role of banality as a critical and polyvalent category, rather than a negative trait. The study argues that Hall’s work illustrates how Neue Sachlichkeit enabled the revaluation of the everyday and the banal, offering a framework to reassess popular elements within twentieth-century art music.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_tolgforsstina_2025, title = {"The connection between assessment and interventions is usually easy to see, but the actual implementation can be more challenging" : A pilot study on the realisation of special support in compulsory school in Sweden}, author = {Tolgfors, Stina and Sjöqvist, Anna}, year = {2025}, url = {1957628}, language = {eng}, file = {https://oru.diva-portal.org/smash/get/diva2:1957628/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_darwishmaria_2025_1, title = {The contemplative man : 'positive' affect and masculinity in ecofascist visual communication}, author = {Darwish, Maria and Gottzén, Lucas}, year = {2025}, journal = {Journal of Gender Studies}, doi = {10.1080/09589236.2025.2479797}, url = {1948198}, language = {eng}, publisher = {Routledge}, keywords = {affect; ecofascism; far right; masculinity; social media}, abstract = {Masculinity in far-right visual media is often portrayed through intimidating images of dominant, militant men. However, this study of affect in Nordic ecofascist visual communication shows that men are also depicted in meditative stillness surrounded by spectacular nature. Such 'positive' representations contrast with the typical far-right depictions of militant masculinity. This paper examines how positive affective communication shapes far-right masculinity, focusing on the trope we call 'the contemplative man'. Inspired by affect theory and social semiotics, we analyse images from ecofascist Telegram channels that show men alone and together in nature participating in meditative and nature-connected practices. We demonstrate how the 'contemplative man' trope broadens the range of available far-right masculine identities and connects men with nature through nativism. We argue that nature in ecofascist discourse allows for 'quieter' expressions of masculinity, providing a space for men to experience intimacy, spirituality and pleasure, alongside the traditional militant persona. Such forms of masculinity visualize the 'blood and soil' complex through natural imagery depicting outdoor activities such as cooking, hiking, and resting in peaceful solitude. This discourse fosters a special bond between white, Nordic men and the land, offering them a place in the social hierarchy and a role within ecology on both sensory and ideological levels.}, issn = {0958-9236} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_paulsruddavid_2025, title = {The control of time in teachers' work : How teachers co-construct narratives about their profession in social media groups}, author = {Paulsrud, David and Bergh, Andreas and Hultman, Annica Löfdahl}, year = {2025}, journal = {Scandinavian Journal of Educational Research}, doi = {10.1080/00313831.2025.2550256}, url = {1999410}, language = {eng}, publisher = {Routledge}, keywords = {teacher professionalism; responsibility; accountability; social media; narrative research}, abstract = {This paper explores how teachers in a Swedish teacher "rebellion" group on Facebook discuss institutional expectations related to the use of time in teachers' work. Drawing on a narrative research tradition, group discussions are analyzed as negotiations where teachers co-construct their own narratives about the teaching profession. In this endeavor, the analytical focus is turned towards how the teachers' discussions relate to notions of professional responsibility and accountability. The results highlight that the teachers emphasize a desire to be trusted, but also that they need to deserve such trust by acting responsibly towards the needs of the whole school. Group discussions on these matters illustrate a tension between teachers' individual autonomy and collective responsibility. While the teachers emphasize teaching-related duties as the core part of their work, their narratives about the professional teacher were constructed in argumentations where the room for discussing social and relational aspects of education was limited.}, issn = {0031-3831}, file = {https://oru.diva-portal.org/smash/get/diva2:1999410/FULLTEXT01.pdf} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kolkowskaella_2025_1, title = {The Development of a Blueprint for a master program - AI-supported business development in public organizations}, author = {Kolkowska, Ella and Lagsten, Jenny}, year = {2025}, url = {2032355}, language = {eng}, publisher = {Örebro universitet}, keywords = {business development; ai; public organisations}, abstract = {This report presents the development of a blueprint for a Master’s program tailored to public sector professionals without formal technical or programming backgrounds. The blueprint was developed as a part of WASP-ED (The Wallenberg AI and Transformative Technologies Education Development Program) work area 2. The program addresses the growing need for competencies among public servants leading or participating in AI-supported transformation in public organizations. It aims to equip domain experts with foundational AI knowledge and cross-disciplinary insight into the intersection of technology, society, and individuals. The goal is to bridge the knowledge gap between technical experts and sector-specific specialists.The blueprint responds to knowledge gaps identified through a review of academic literature on AI system development and implementation in public organizations, recent reports from public and private entities, and complemented by empirical data collected through workshops, discussions, and interviews with key stakeholders. The suggested program is grounded in both theory and practice, drawing on the Sociotechnical AI systems perspective and the AI System Development Life Cycle (AI-DLC), designed specifically for public sector needs.The initial version of the blueprint was shared with stakeholders including study directors, and others involved in developing Master's-level education in relevant disciplines. It was also evaluated against the WASP-ED curriculum and existing Master’s programs in Sweden.Finally, there is a strong network of informatics researchers across Sweden — including at Örebro University (ÖRU), University of Gothenburg (GU), Linköping University (LiU), and Mid Sweden University — who possess relevant expertise, actively publish in this field, and maintain close collaborations with the public sector. These competencies and networks will play a key role in shaping and further developing the program.}, file = {https://oru.diva-portal.org/smash/get/diva2:2032355/FULLTEXT01.pdf} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_kerezoudievangelia_2025, title = {The Dietary Fibre–Barrier Alliance : Bridging Gut Integrity, Microbiota Function and Immune Regulation}, author = {Kerezoudi, Evangelia}, year = {2025}, url = {1942092}, language = {eng}, publisher = {Örebro University}, keywords = {prebiotics; fungal polysaccharides; pectic polysaccharides; barrier stress models; microbiome modulation; microbial metabolism; immune training; intestinal permeability; precision gut health}, abstract = {Dietary fibres are key modulators of gut health, including barrier integrity and immune function, yet these effects are not sufficiently characterised. β-Glucans and rhamnogalacturonan-I (RG-I) have been shown to shape microbial composition and immune signalling, but their specific contributions to barrier integrity require further elucidation. Paper I examines how faecal fermentation supernatants (FS) from Pleurotus eryngii (PE) cultivated on distinct substrates influence intestinal barrier integrity in an LPS-stimulated Caco-2 model, revealing substrate-driven variations in tight junction modulation. Paper II describes the comparative effects of whole PE, its digested derivatives and a β-glucan-enriched extract on gut microbiota composition and metabolism in elderly individuals, using an in vitro fermentation model, highlighting the superior modulatory potential of the whole PE. Paper III explores the immunoregulatory properties of PE’s FS in an LPS-stimulated Caco-2 model, demonstrating their role in cytokine signal-ling and barrier’s protection. Paper IV evaluates the capacity of PE FS to mitigate bile acid-induced barrier dysfunction in in vitro and ex vivo colonic models, underscoring their protective effects against hyperpermeability. Paper V investigates the prebiotic potential of carrot RG-I in a human intervention study, showing its ability to enhance bifidobacteria populations, modulate immune responses and support barrier integrity. In conclusion, this thesis advances the understanding of dietary fibre bioactivities beyond conventional microbiota analyses. By demonstrating that β-glucans and RG-I modulate epithelial and immune functions alongside microbial interactions, it establishes a mechanistic foundation for precision nutrition strategies targeting gut health through an integrated, systems-based approach.}, file = {https://oru.diva-portal.org/smash/get/diva2:1942092/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jarlbrinkjohan_2025, title = {The Disappearing Winter : The Diminishing of Seasonal Variations in the Circulation of News. The Case of Sweden 1790 to 1829}, author = {Jarlbrink, Johan and Lundell, Patrik}, year = {2025}, journal = {TMG Journal for Media History}, volume = {28}, number = {1}, pages = {1--31}, doi = {10.18146/tmg.879}, url = {1983452}, language = {eng}, publisher = {Netherlands Institute for Sound & Vision}, keywords = {newspapers; seasonal variations; text reuse; digital history; nineteenth-century sweden}, abstract = {Seasonal and maritime-related variations in newspaper content and circulation speed have been observed in the literature. This study of Swedish conditions 1790–1829 documents such differences. However, its focus is on domestic circulation and its dependence upon, among other things, incoming foreign news. By combining a computer-assisted method that tracks text reuse with close readings, and by breaking down the circulation into genres and categories of duration, historical change in these variations is made visible. While previous research has emphasised the explanatory power of technology, this article shows that more factors must be considered. Although technological infrastructural advancements were very limited, circulation times decreased and seasonal variations were evened out. This is best explained, this article suggests, by the growth of the system itself, by overall policy changes and by the increased scope for individual actors to change the culture and the protocols of the system, whether intentionally or not.}, issn = {1387-649X}, file = {https://oru.diva-portal.org/smash/get/diva2:1983452/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sjbergklas_2025, title = {The disease course in microscopic colitis may be influenced by hormonal factors}, author = {Sjöberg, Klas and Vigren, Lina and Mellander, Marie-Rose and Janczewska, Izabella and Strid, Hans and Hultgren Hörnquist, Elisabeth and Münch, Andreas}, year = {2025}, journal = {BMC Gastroenterology}, volume = {25}, number = {1}, doi = {10.1186/s12876-025-04083-8}, url = {1975340}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {contraceptives; estrogen; mht; microscopic colitis; oophorectomy; sex hormones}, abstract = {BACKGROUND: Microscopic colitis (MC) is characterized by non-bloody, watery diarrhea predominantly in elderly women. Known risk factors are smoking, medication with NSAIDs, PPIs or SSRIs, while data on hormonal factors is sparse. The aim of the present study was to investigate whether hormonal factors that disrupt the sex hormonal balance could have an impact on the disease course in MC.METHODS: A questionnaire was distributed to 384 women with microscopic colitis (MC) (mean age 64 years, range 35-90) from five centers in Sweden about demographic aspects including age at diagnosis, disease duration, treatment, and polycystic ovary syndrome, endometriosis, bilateral oophorectomy, previous or ongoing medication with hormones or in vitro fertilization (IVF) in relation to the disease course.RESULTS: The association with smoking could be verified. In relation to the disease course the odds ratio (OR) was higher for celiac disease and oral contraceptives but lower for hormone replacement therapy but for the two latter non-significant. However, bilateral oophorectomy had a significantly lower OR (0.41, CI 0.19-0.86, p = 0.019). No other factors had any substantial impact on the disease course.CONCLUSION: An association was verified with smoking. Celiac disease may be associated with more active disease. The observed lower OR for more active disease after bilateral oophorectomy is in line with a previously suggested association between the risk of MC and the hormonal balance. The exact mechanisms behind the hormonal effect on the disease course found in the present study are although still obscure.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_stjohnoliver_2025_1, title = {The educational value of a family support worker}, author = {St John, Oliver and Ålander, Jonas and Liyanage, Lovisa}, year = {2025}, pages = {105--106}, url = {1967906}, language = {eng}, keywords = {family support worker; parents; cooperation; trust}, abstract = {Governments have long focused on supporting parents through social services and schools as key platforms for promoting health and addressing educational and societal issues. However, while civil servants believe schools underestimate their capacity to support parents, educators argue that parenting support is not part of the curriculum. In Sweden, teachers are required to inform parents about their children's development, rather than offer parenting support services. Research shows, however, that parental involvement increases children's success in school. Against this background, the intervention of a family support 101 worker (FSW) is a novel educational move. Two questions are addressed, “How does the FSW promote school-home relationships?” and “What effect does this work have on pupils’ prerequisites to succeed in school?”.  Georg Simmel describes trust as "a hypothesis certain enough to serve as a basis for practical conduct," emphasizing that it can bridge the gap between the known and unknown. He introduces the triad, involving three elements, as “a social framework that transcends both members of the dyad” which can enhance relationships by allowing a third party to mediate.  The project is a research collaboration between academics and school staff. Data collection methods include surveys for parents and teachers, reflective protocols for teachers, interviews with school leader and FSW as well as parent and teacher group interviews. This approach allows each stage’s results to inform the next, creating a progressive contextual framework for content analysis. Expected outcomes include; A strong statement from school personnel and parents about the value of school-based FSWs in promoting student success; Results that can be adopted by other schools, encouraging leadership to invest in family-school partnerships through FSWs; A meaningful contribution to international research on school-based parenting support, highlighting the role of family support workers in enhancing family life and child learning and development.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_renouxjennifer_2025, title = {The Effect of Agent-Based Feedback on Prosociality in Social Dilemmas}, author = {Renoux, Jennifer and Correia, Filipa and Campos, Joana and Morillo-Mendez, Lucas and Akalin, Neziha and Santos, Fernando P. and Paiva, Ana}, year = {2025}, pages = {1755--1763}, url = {1999366}, language = {eng}, publisher = {International Foundation for Autonomous Agents and Multiagent Systems}, keywords = {prosociality; collective risk dilemma; human-agent interaction; game theory; asymmetric risk}, abstract = {Tackling many of humanity's contemporary challenges requires individuals to cooperate in so-called collective risk dilemmas, i.e. scenarios where cooperation is costly yet required to reach collective targets and prevent catastrophic outcomes. It remains a scientific challenge to understand which external incentives enable cooperation and whether that can be facilitated through socially interactive agents. In this paper, we evaluate human cooperation in the presence of an artificial virtual agent. We developed a game called The Pest Control, in which five players attempt to maximize their earnings while avoiding being infested by a spreading pest. Controlling the pest requires costly public good contributions, yet free-riding on the efforts of others leads to maximum individual payoffs. We conducted an online experiment and analyzed the data of 265 participants, where we manipulated the feedback strategy of the virtual agent in a between-subject design. Our results suggest that feedback highlighting salient elements of the game increases participants' cooperation, while feedback regarding the consequences of actions slightly promotes selfish behaviors. Our study provides insight into how future artificial agents and AI systems could be designed to promote cooperation in complex social dilemmas by leveraging different strategies.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wistrandcamilla_2025_2, title = {The effect of five versus two personnel on bacterial air contamination during preparation of sterile surgical goods in the operating room : a randomised controlled trial}, author = {Wistrand, Camilla and Söderquist, Bo and Sundqvist, Ann-Sofie}, year = {2025}, journal = {Antimicrobial Resistance and Infection Control}, volume = {14}, number = {1}, doi = {10.1186/s13756-025-01589-4}, url = {1969927}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {air quality; contamination; infection control; microorganism; operating room; surgical instrument; surgical site infection}, abstract = {BACKGROUND: Surgical site infection (SSI) and antimicrobial resistance are a worldwide problem affecting patient safety. It is lacking randomised controlled trials (RCT) regarding how the number of personnel in the operating room (OR) affects the air quality. We aimed to investigate the effect the number of personnel in the OR have on bacterial air contamination during the preparation of sterile surgical goods, to identify the species and antibiotic susceptibility of the bacteria isolated, and to describe the number of SSIs together with causative microorganisms.METHODS: This RCT used an intervention group in which two individuals prepared the surgical goods and a control group in which five individuals prepared the goods. Bacteria were isolated on aerobic and anaerobic plates, and bacterial growth was measured as colony forming units (CFU). All isolates were typed, and types known to cause SSI were tested for susceptibility to eight antibiotics. Data were analysed with the Mann-Whitney U test, the chi-square test, or Fisher's exact test.RESULTS: Results were based on 69 open-heart surgeries and 414 plates. When sterile surgical goods were prepared with two personnel, the median CFU was 2 with an IQR of 2, compared with five personnel, the median CFU was 5, with an IQR of 5 (p < 0.001). The 272 CFU represented 45 different bacterial species, with 38 species isolated in the control group and 21 in the intervention group. The most frequently isolated bacteria were Cutibacterium acnes (82/272, 30%), and Staphylococcus epidermidis (36/272, 13%). Of the 36 S. epidermidis isolates, 11 (31%) were drug-resistant, including three multidrug-resistant. One patient in the control group was infected by Staphyloccocus aureus and Staphylococcus lugdunensis, neither of which was isolated during the preparation of sterile goods. One patient in the intervention group developed an SSI caused by C. acnes, Corynebacterium kroppenstedtii, and S. epidermidis. C. acnes and S. epidermidis were isolated during the preparation.CONCLUSIONS: Minimising the number of personnel in the OR during preparation of sterile surgical goods is important to reduce the bacterial load.TRIAL REGISTRATION: Prospectively 15 May 2022 at FoU Sweden (275659) and retrospectively 22 October 2022 at ClinicalTrials.Gov (NCT05597072).} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_knutssondaniel_2025, title = {The effect of water filtration on cholera mortality}, author = {Knutsson, Daniel}, year = {2025}, journal = {Journal of Urban Economics}, volume = {147}, doi = {10.1016/j.jue.2025.103752}, url = {1945614}, language = {eng}, publisher = {Elsevier}, keywords = {water; piped water; filtered water; cholera; mortality; public health}, abstract = {This paper examines how water filtration and distribution helped reduce mortality during a cholera outbreak. Using household water contract records and individual mortality data, I analyze the impact of filtered water with an event study approach. The results show that having access to filtered water at home greatly reduced the risk of death. This suggests that water filtration and distribution were key public health measures in lowering mortality from waterborne diseases in the 19th and early 20th centuries. Improvements in urban water systems could have played a major role in the decline of cholera outbreaks and mortality during this period.}, issn = {0094-1190} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stenbergerik_2025_3, title = {The effect of weight change on death and cardiovascular events after Roux-en-Y gastric bypass}, author = {Stenberg, Erik and Näslund, Erik and Cao, Yang and Ottosson, Johan and Näslund, Ingmar}, year = {2025}, journal = {British Journal of Surgery}, volume = {112}, number = {8}, doi = {10.1093/bjs/znaf170}, url = {1990298}, language = {eng}, publisher = {Oxford University Press}, abstract = {BACKGROUND: Weight changes after Roux-en-Y gastric bypass (RYGB) follow different trajectories, but the effects of different trajectories on death and cardiovascular events are largely unknown. The aim of the current study was therefore to evaluate the effects of weight changes after RYGB on cardiovascular events and mortality rate.METHODS: This cohort study included patients who underwent primary RYGB in Sweden from 2007 to 2018 with a complete registration of weight at baseline, at nadir weight loss and 5-year follow-up (n = 25 230) with a mean BMI of 42.1 ± 5.2 kg/m2, age 42.5 ± 11.2 years, and 19 420 (77%) women. Patients were stratified based on weight change from nadir weight loss. The main outcome measures were major cardiovascular event (MACE) or death.RESULTS: Over a mean follow-up of 10.6 years, 1276 patients experienced at least one episode of a MACE, and 707 died. An increased risk for death and MACE was seen in patients with continued weight loss after nadir (adjusted HR compared to recurrent weight gain of 0-20% of weight lost at nadir among patients who initially lost 20-35% total weight (TWL): 1.80 (1.41-2.31) and 1.62 (1.35-1.94) respectively), and for patients who experienced >50% recurrent weight gain from nadir (adjusted HR compared to patients with recurrent weight gained 0-20% TWL: 1.61 (1.07-2.43) and 1.48 (1.09-2.00) respectively).CONCLUSION: Continued weight loss and significant recurrent weight gain after the initial weight nadir were both associated with a higher risk for MACE and death after RYGB. These should be considered non-desirable weight trajectories requiring further clinical evaluation and increased support.}, issn = {0007-1323} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_grdlingj_2025, title = {The effects of virtual reality (VR) on clinical skills training in undergraduate radiography education : A systematic review}, author = {Gårdling, J. and Viseu, C. and Hettinger, E. and Jildenstål, Pether and Augustinsson, A.}, year = {2025}, journal = {Radiography}, volume = {31}, number = {3}, doi = {10.1016/j.radi.2025.102911}, url = {1943004}, language = {eng}, publisher = {Elsevier}, keywords = {confidence; performance; pitfalls; radiography; students; virtual reality}, abstract = {INTRODUCTION: The primary objective was to map the impact on confidence and performance on radiographic examinations among undergraduate radiography students utilizing virtual reality (VR). The secondary objective was to identify potential pitfalls to avoid in future VR implementation.METHODS: A systematic review was conducted, which included comprehensive search in nine databases. The software Covidence was used for screening. Nine studies were included after quality assurance using the Critical Appraisal Skills Programme (CASP). Data extraction consisted of participant characteristics, study design, relevant statistical results, study limitations, and conclusions. Key findings were summarized in a systematic synthesis.RESULTS: VR compared to traditional skills training provides an advantage in students' assessed performance in both equipment and patient positioning, as well as self-reported confidence within equipment positioning, selection of exposure parameters, and radiation safety. For successful outcome, factors to consider were the size of the VR room, VR tutorials, the length of the VR-session, a realistic VR environment, feedback from the VR system, and the opportunity to interact with patients, both verbally and palpatory.CONCLUSION: VR is a feasible tool, providing students with a safe, engaging, and controlled environment. Students may apply their theoretical knowledge into real-life scenarios, which develop students' clinical skills, critical thinking, and decision-making abilities.IMPLICATIONS FOR PRACTICE: Although VR has shown positive effects, VR alone does not guarantee increased performance and confidence in students. Research within this field is deficient, hence further research is needed to confirm the effect of VR, preferably case-control or randomized studies.}, issn = {1078-8174} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gilesclover_2025, title = {The efficacy of psychological prevention, and health promotion interventions targeting psychological health, wellbeing or resilience among forced migrant children and youth : a systematic review and meta-analysis}, author = {Giles, Clover and Västhagen, Maja and van Leuven, Livia and Edenius, Anna and Ghaderi, Ata and Enebrink, Pia}, year = {2025}, journal = {European Child and Adolescent Psychiatry}, volume = {34}, number = {1}, pages = {123--140}, doi = {10.1007/s00787-024-02424-8}, url = {1852138}, language = {eng}, publisher = {Springer}, keywords = {children and youth; forcibly displaced; prevention; promotion; psychological interventions; refugee}, abstract = {There are over 40 million displaced children and youth worldwide and there is a need promote their mental wellbeing. This study aimed to synthesize evidence regarding promotion interventions to increase wellbeing, resilience, and quality of life (primary outcomes), and prevention interventions to reduce internalizing and externalizing symptoms (secondary outcomes) in this population. The review protocol was registered with PROSPERO (CRD42022329978). Medline, PsycINFO, and Web of Science were searched. Inclusion criteria were: ≥ 10 participants, sample ≤ 18 years of age, no parental participation, explicated forced migrant populations, implementation in non-clinical context, and validated measures. Fifteen studies (N interventions = 18, N participants = 5741) were eligible. Two studies included outcomes related to wellbeing and quality of life. The remaining studies reported depression, PTSD, anxiety, internalizing and externalizing behaviours, and behavioural and emotional problems. There was only sufficient data to perform random-effects meta-analysis of depression scores. No significant effects were observed in comparison to control condition in randomized trials (n = 4994, k = 5) but a small significant positive trend was observed in within-group analyses (n = 537, k = 12). Cochrane's risk of bias tools and the GRADE certainty of evidence tool were applied. No studies achieved low risk of bias and certainty of evidence was very low. In sum, there remains a dearth of rigorous intervention studies investigating the effects of promotive and preventative psychological interventions on the wellbeing, resilience, and quality of life of forcibly displaced minors. However, the few eligible studies in this review indicate promise.}, issn = {1018-8827} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_quennerstedtann_2025_3, title = {The elusive content of children's human rights education}, author = {Quennerstedt, Ann and Gawlicz, Katarzyna and Duda, Dorota and Francia, Guadalupe}, year = {2025}, journal = {Journal of Curriculum Studies}, doi = {10.1080/00220272.2025.2578739}, url = {2014169}, language = {eng}, publisher = {Routledge}, keywords = {human rights education; children's rights education; hre; cre; educational content}, abstract = {There is strong support for educating children and young people about their human rights, but there is also widespread uncertainty about what this education should consist of-what the content of children's human rights education should be. This article maps and synthesizes what previous research has identified as the main content areas and suggests a terminology for talking about content in education about, through and for rights. Drawing on two theoretical perspectives on educational content-the powerful knowledge approach and Didaktik theory-a vocabulary for identifying different kinds of content was generated and used to analyze intended, enacted or suggested content displayed in earlier research. The findings show that high attention is paid to content in education about rights, which is demonstrated in almost all publications in a well-elaborated and detailed manner. In contrast, content in education through rights is found to be little addressed and elaborated in the analyzed research. Meagre elaboration is also the case for content in education for rights, although this is displayed in a higher number of publications. Content themes for education about, through and for rights are identified and described, and these are suggested to serve as a basis for further research.}, issn = {0022-0272} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_edinmartin_2025, title = {The English Garden Fantasy : Rule Poetics and Transformation Strategies in Carl Czerny's Teaching of Piano Improvisation}, author = {Edin, Martin}, year = {2025}, url = {1953884}, language = {eng}, publisher = {Örebro University}, keywords = {czerny; nineteenth-century improvisation; piano improvisation; rule poetics; imitation; spontaneity; english garden}, abstract = {This thesis investigates the Viennese pianist, composer, and pedagogue Carl Czerny’s approach to piano improvisation in his Systematische Anleitung zum Fantasieren op. 200 (1829) and Die Kunst des Präludirens op. 300 (1834). Most research on eighteenth and nineteenth-century keyboard improvisation has been focused on the prominent role of thoroughbass-based, standardized harmonic patterns in the improvisation pedagogy of these eras, and on techniques for figuration and contrapuntal elaboration of such patterns. The present work is founded on the insights of previous research, but it is mainly concerned with the central role of genres, styles, and characters in Czerny’s approach to improvisation. With this shift of focus, an essential and hitherto neglected part of the craft of improvisation that Czerny teaches is disclosed.For Czerny, the style and character of an improvisation should be akin to an English garden—seemingly ruleless but based on rational principles. Through a close reading of his method, the present dissertation shows how this English garden ideal is concretely expressed in Czerny’s approach to fantasizing.The thesis situates Czerny’s method in relation to ideas from the tradition of rhetorically influenced, genre-based rule-poetics—a perspective that has not received enough attention in previous research on Czerny and early nineteenth century piano improvisation. The study investigates the meanings and implications of the interplay between genre-based rule poetics, transformative imitation, and the aesthetic ideal of the English garden in Czerny’s approach. The thesis thus offers new insights into Czerny's conception of imitation and models, as well as into how genres, style types, and transformation strategies are governed by aptum (appropriateness) criteria.The study argues that Czerny’s improvisation method amounts to a pedagogy for stylistic appropriateness. But it also shows how Czerny incorporates pre-romantic notions of spontaneity into his rule-regulated genre system, thus interpreting spontaneity as a form of craft. In other words, Czerny’s instruction on fantasizing conveys rules for a seeming rulelessness.}, file = {https://oru.diva-portal.org/smash/get/diva2:1953884/FULLTEXT03.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bergmonika_2025_1, title = {The epistemic and the political : the play of measuring, managing, and governing ecosystems through woodland key habitats}, author = {Berg, Monika and Sataøen, Hogne L. and Andersen, Gisle}, year = {2025}, journal = {Environmental Sociology}, pages = {1--14}, doi = {10.1080/23251042.2025.2507273}, url = {1961470}, language = {eng}, publisher = {Taylor & Francis}, keywords = {forest policy; environmental measurements; environmental governance; woodland key habitats; knowledge; politicization}, abstract = {This paper explores how contestation unfolds within the interconnected processes of governing, managing, and measuring nature, using Swedish forest policy and Woodland Key Habitats (WKHs) as a case study. It illustrates how contestation rooted in different interests and worldviews manifests as epistemic struggles within the state apparatus. Based on document analysis and expert interviews with policymakers, researchers, and stakeholders, the paper traces the development of WKHs since the 1990s as a method, grounded in an ecosystem approach, for measuring the ecological value of a forest, as well as the subsequent politicization and contestation of the method that has played out over the past decade. Rather than targeting political goals, the contestation is directed at the objectivity, legality, and reasonableness of WKHs. The contestation led to a revision of the classification criteria and eventually the termination of the assessments. This case underscores how the deep entanglement of values and facts is essential both for driving change and for understanding the limited implementation of more progressive ecosystem-oriented policies. Assessing this triadic interrelationship between governing, managing, and measuring nature provides a deeper understanding of how contestation plays out and impacts environmental governance.}, issn = {2325-1042} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bergjacob_2025_2, title = {The European Public Prosecutor’s Office - Supranationalism, sovereignty and legitimacy}, author = {Öberg, Jacob}, year = {2025}, journal = {European Law Review}, url = {1996852}, language = {eng}, publisher = {Sweet & Maxwell}, keywords = {eu law; eu criminal law; criminal justice; eppo}, abstract = {This article offers a critical analysis of the evolution, structure and functioning of the European Public Prosecutor’s Office (EPPO) based on the three interrelated concepts of supranationalism, sovereignty and legitimacy. The first part of the article critically analyses the current design of the EPPO’s powers and how they have been exercised in practice, seeking to establish the nature of this body along the supranational-intergovernmental spectrum. The second part examines the operating structure and management of the EPPO, attempting to ascertain the extent to which Member States have been capable of maintaining control of its operation. Arguing that the EPPO to date is the pinnacle of supranational criminal justice, the article considers to what extent the establishment of this body and the wielding of significant law enforcement powers can be reconciled with the dictates of state sovereignty. Finally, the article considers the EPPO from the perspective of legitimacy and argues that the EPPO needs to demonstrate not only a successful track record in its law enforcement actions, but also that the operational actions of this new supranational body are encased within a strong legal framework with robust judicial remedies and safeguards for individual defendants.}, issn = {0307-5400} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_beimekristina_2025, title = {The exclusion of deviant employees : A Foucauldian analysis of disciplinary power in organizations}, author = {Beime, Kristina and Lundh, Simon}, year = {2025}, journal = {Organization}, doi = {10.1177/13505084251325295}, url = {1955382}, language = {eng}, publisher = {Sage Publications}, keywords = {disciplinary power; exclusion; deviance; normalization; organizational control; workplace discipline; foucault; foucauldian analysis; power dynamics; organizational governance}, abstract = {While studies of disciplinary power have largely focused on how employees conform, resist, or adapt to organizational norms, less attention has been paid to what happens when normalization efforts fail, leading to exclusion. Drawing on Michel Foucault’s concept of disciplinary power, this article examines how top management handles employees who persistently deviate from organizational expectations. Based on an empirical study of managerial responses to two types of deviant employees—underperformers and socially nonconforming individuals—we reveal how exclusion emerges as an escalating process. Initially, managers employ corrective measures aimed at normalization, yet when these efforts prove unsuccessful, they shift toward intensified control, documentation, and ultimately, exclusion. Our findings demonstrate that exclusion is not a failure of disciplinary power but rather its extension, reinforcing organizational norms through the removal of those deemed irredeemably deviant. By conceptualizing exclusion as an active disciplinary mechanism rather than a passive outcome, this study contributes to a deeper understanding of power dynamics in contemporary organizations.}, issn = {1350-5084} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kofodl_2025_1, title = {The Experience of Automated Home Oxygen Therapy for Patients With COPD - A Qualitative Study}, author = {Kofod, L. and Laursen, L. B. and Westerdahl, Elisabeth and Hansen, E. F. and Brocki, B. C. and Kristensen, M. T. and Bove, D. G.}, year = {2025}, journal = {American Journal of Respiratory and Critical Care Medicine}, volume = {211}, number = {Suppl.}, doi = {10.1164/ajrccm.2025.211.Abstracts.A7306}, url = {1961468}, language = {eng}, publisher = {HighWire Press}, abstract = {Rationale: The present study included the first patients with COPD on long-term oxygen therapy who experienced second-by-second oxygen adjustments in their homes based on oxygen saturation. A device capable of automatically titrating the patient's oxygen was installed in the patients´ home aiming at increasing the time spent within target saturation. We explored patients´ experiences with this automated home oxygen titration, focusing on how maintaining target saturation affected daily life.Methods: Semi-structured interviews were conducted with eight men and four women after they have had the automated oxygen equipment installation in their homes. Systematic text condensation was used in the analysis.Results: Three main themes emerged from patient narratives: 1) "This is my life" - Patients preferred maintaining stable oxygen saturation, associating hypoxemia with dyspnea, discomfort, and difficulties with daily tasks. 2) "Getting the oxygen, I need" - Many patients reported improved ability to perform daily activities when oxygen was automatically adjusted. 3) "New technology gives hope for my life" - Patients expressed optimism about the potential of home-based technology, offering suggestions to improve usability, mainly by reducing concentrator noise.Conclusion: Our findings suggested high acceptability of the automated oxygen in the patients´ home, as they believed it to increase the time spend with sufficient oxygen, especially during daily activities. Integrating patient insights is essential for implementation and acceptance of automated home oxygen therapy.}, issn = {1073-449X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kofodlinette_2025, title = {The Experience of Automated Home Oxygen Therapy for Patients With COPD - A Qualitative Study}, author = {Kofod, Linette and Laursen, Louise Bolvig and Westerdahl, Elisabeth and Hansen, Ejvind Frausing and Brocki, Barbara Cristina and Kristensen, Morten Tange and Bove, Dorthe Gaby}, year = {2025}, journal = {COPD: Journal of Chronic Obstructive Pulmonary Disease}, volume = {22}, number = {1}, doi = {10.1080/15412555.2025.2477243}, url = {1948204}, language = {eng}, publisher = {Informa Healthcare}, keywords = {automated oxygen titration; activities of daily living; closed-loop; long-term oxygen therapy; oxygen saturation; technology}, abstract = {The present study included the first patients with COPD on long-term oxygen therapy who experienced second-by-second oxygen adjustments in their homes based on oxygen saturation. A device capable of automatically titrating the patient's oxygen was installed in the patients' home aiming at increasing the time spent within target saturation. We explored patients' experiences with this automated home oxygen titration, focusing on how maintaining target saturation affected daily life. Semi-structured interviews were conducted with eight men and four women after installation. Systematic text condensation was used in the analysis. Three main themes emerged from patient narratives: (1) "This is my life" - Patients preferred maintaining stable oxygen saturation, associating hypoxemia with dyspnea, discomfort, and difficulties with daily tasks. (2) "Getting the oxygen, I need" - Many patients reported improved ability to perform daily activities when oxygen was automatically adjusted. (3) "New technology gives hope for my life" - Patients expressed optimism about the potential of home-based technology, offering suggestions to improve usability, mainly by reducing concentrator noise. Our findings suggested high acceptability of the automated oxygen in the patients' home, as they believed it to increase the time spend with sufficient oxygen, especially during daily activities. Integrating patient insights is essential for implementation and acceptance of automated home oxygen therapy.}, issn = {1541-2555} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_ahlbergrickard_2025, title = {The extent to which neurodevelopmental disorders are associated with functional and physical outcomes, and why?}, author = {Ahlberg, Rickard}, year = {2025}, url = {1912748}, language = {eng}, publisher = {Örebro University}, keywords = {adhd; autism; functional impairments; somatic problems}, abstract = {Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism (ASD) are two neurodevelopmental conditions with early onset in the developmental period, high heritability and relatively high stability through the lifespan. The evi-dence base for these findings is considerable. Less researched, however, is the extent to which neurodevelopmental conditions are associated with func-tional and physical outcomes. The impact of ADHD/ASD on physical out-comes like height, obesity, and real-life functional outcomes such as relational instability, job shifting, and residential moves remain unclear. There is also a knowledge gap to what extent there is sex differences in these associations and if the associations are present through the life span. And lastly, a detailed un-derstanding about why these associations is present is also lacking. The overarching goal of this thesis was therefore to advance the understanding of the extent to which neurodevelopmental disorders are associated with functional and physical outcomes, and why. In study I-IV, we used data from Swedish population registers. We found that individuals with ASD and their relatives are at increased risk for obesity, and that the risk is partly familial in nature (study I). Further, our findings suggest that ADHD, rather than ADHD medication, is associated with shorter height and that the association between ADHD and shorter height is partly due to a shared familial liability (study II). We also found that both men and women (from young to older adulthood) with ADHD have a higher rate of residential moves, relational instability and job shifting (study III). Finally, we found that individuals with ADHD have an increased risk of sleeping disorders, from childhood to older adulthood (study IV).The findings from this thesis highlight the importance of a life-span per-spective of neurodevelopmental disorders, and importantly - a focus that ex-tends beyond the core ADHD symptoms to include psychiatric and physical comorbidity as well as real-life functional outcomes. Thus, our findings also point to the need for integrated care between psychiatric and physical care and helping people with neurodevelopmental conditions to navigate across health care and social systems for their functional and physical problems.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_oskarssonsofi_2025_1, title = {The Familial Co-Aggregation of ADHD and Criminal Convictions : A Register-Based Cohort Study}, author = {Oskarsson, Sofi and Kuja-Halkola, Ralf and Andersson, Anneli and Tuvblad, Catherine and Brikell, Isabell and D’Onofrio, Brian and Chang, Zheng and Larsson, Henrik}, year = {2025}, journal = {Biological Psychiatry}, doi = {10.1016/j.biopsych.2025.10.007}, url = {2007167}, language = {eng}, publisher = {Elsevier}, abstract = {Background: The association between ADHD and criminality is well established, yet little is known about the familial liability of ADHD and crime across different types of relatives, from twins to cousins. This study aims to clarify the association between ADHD and crime by examining their co-aggregation both in the general population and across a range of familial relationships in a nationwide population-based sample, including separate analyses for men and women.Methods: We analyzed data from 1,507,211 individuals born in Sweden between 1987 and 2002. Using Cox proportional hazard regressions, we estimated the associations between clinically diagnosed ADHD and official crime records within individuals and families.Results: Analyses showed that individuals with ADHD had a significantly higher risk of being convicted of any crime—violent or non-violent—compared to those without ADHD, with the risk being significantly higher for women than men. Additionally, individuals with a relative diagnosed with ADHD were at increased risk of criminal convictions, with some gender-based variations.Conclusions: ADHD and criminal convictions co-aggregate within families, consistent with shared familial liability. Patterns across relatives and sexes suggest genetic contributions, with stronger associations in women. These findings may help inform risk assessment and prevention efforts.}, issn = {0006-3223} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindnerheleny_2025, title = {The feasibility of using eye-tracking technology for cognitive screening in Down syndrome with dementia : A cross-sectional case series}, author = {Lindner, Helen Y and Merabet, Lotfi B. and Lundqvist, Lars-Olov}, year = {2025}, journal = {Alzheimer's & Dementia: Journal of the Alzheimer's Association}, volume = {21}, number = {6}, doi = {10.1002/alz.70385}, url = {1971042}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {down syndrome; cognition; dementia; eye‐tracking; screening}, abstract = {INTRODUCTION: Adults with Down syndrome (DS) are at a high risk for dementia, yet cognitive screening is complicated by premorbid intellectual disabilities. This study evaluated the feasibility of using eye-tracking technology as a screening tool.METHODS: Ten adults with DS (five with dementia, five without) completed cognitive tasks while their eye movements were recorded. Feasibility was assessed through calibration success, gaze sample quality, and task completion.RESULTS: Calibration was successful for most subjects (except one individual with dementia required five attempts and had low gaze sampling). Most subjects achieved 50%-88% gaze sample rates and completed testing with staff support. Subjects with dementia showed longer times to first fixation but similar fixation durations compared to those without dementia. Cognitive scores were lower in the dementia group but not significantly correlated with gaze quality.DISCUSSION: Eye tracking may be a feasible method for cognitive screening in DS, but further validation is needed. HIGHLIGHTS: Eye-tracking may be a potential non-verbal method for cognitive screening in individuals with DS. Support from staff for engaging the subjects could be essential for maintaining attention on the computer screen.}, issn = {1552-5260} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_cceresdomnguezdavid_2025, title = {The First WARA Robotics Mobile Manipulation Challenge - Lessons Learned}, author = {Cáceres Domínguez, David and Iannotta, Marco and Kashyap, Abhishek and Sun, Shuo and Yang, Yuxuan and Cella, Christian and Colombo, Matteo and Pelosi, Martina and Preziosa, Giuseppe Fabio and Tafuro, Alessandra and Zappa, Isacco and Busch, Finn and Dong, Yifei and Longhini, Alberta and Lu, Haofei and Cabral Muchacho, Rafael I. and Styrud, Jonathan and Fregnan, Sebastiano and Guberina, Marko and Jia, Zheng and Carriero, Graziano and Lindqvist, Sofia and Di Castro, Silvio and Iovino, Matteo}, year = {2025}, doi = {10.1109/ECMR65884.2025.11163319}, url = {2017030}, language = {eng}, publisher = {IEEE}, keywords = {automation; service robots; navigation; mobile robots; mobile manipulation; lab automation}, abstract = {The first WARA Robotics Mobile Manipulation Challenge, held in December 2024 at ABB Corporate Research in Västerås, Sweden, addressed the automation of task-intensive and repetitive manual labor in laboratory environments -- specifically the transport and cleaning of glassware. Designed in collaboration with AstraZeneca, the challenge invited academic teams to develop autonomous robotic systems capable of navigating human-populated lab spaces and performing complex manipulation tasks, such as loading items into industrial dishwashers. This paper presents an overview of the challenge setup, its industrial motivation, and the four distinct approaches proposed by the participating teams. We summarize lessons learned from this edition and propose improvements in design to enable a more effective second iteration to take place in 2025. The initiative bridges an important gap in effective academia-industry collaboration within the domain of autonomous mobile manipulation systems by promoting the development and deployment of} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_frbertole_2025_3, title = {The flu shot and cardiovascular Protection : Rethinking inflammation in ischemic heart disease}, author = {Fröbert, Ole and Pedersen, Ida B. and Hjelholt, Astrid J. and Erikstrup, Christian and Cajander, Sara}, year = {2025}, journal = {Atherosclerosis}, doi = {10.1016/j.atherosclerosis.2025.120405}, url = {1973005}, language = {eng}, publisher = {Elsevier}, keywords = {cardiovascular disease; inflammation; influenza vaccination; myocardial infarction}, abstract = {Influenza infection is a well-established trigger of acute cardiovascular events, particularly myocardial infarction, mediated by systemic inflammation, endothelial dysfunction, and thrombosis. In this review, we examine the evidence supporting influenza vaccination as a preventive strategy in cardiovascular disease. Observational studies and randomized trials consistently show reduced cardiovascular event rates among vaccinated individuals, with the most pronounced benefit seen after myocardial infarction. Emerging data suggest that the effects of vaccination extend beyond infection prevention, involving immunomodulatory effects, including regulatory T cell activity, features of trained innate immunity, and mechanisms promoting resolution of inflammation. Unlike conventional anti-inflammatory therapies, vaccination appears to rebalance immune responses without compromising host defence. We also consider an evolutionary perspective, proposing that historical influenza exposure may have contributed to the genetic architecture of atherosclerosis. Taken together, current evidence positions influenza vaccination as a safe, low-cost, and biologically plausible intervention in the prevention of cardiovascular events. However, important questions remain. Whether revaccination during hospitalization provides added benefit in previously immunized individuals, and the potential of high-dose or next-generation vaccine platforms such as mRNA, warrant further study. Dedicated outcome trials conducted outside the influenza season are especially needed to clarify nonspecific cardiovascular benefits. Cardiologists and other stakeholders share a responsibility to implement existing guidelines with the same commitment given to statins and platelet inhibitors.}, issn = {0021-9150} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ohaganlaurenalex_2025_9, title = {The gender bias in NIVEA® sunscreen advertisements in Sweden : A transhistorical perspective}, author = {O’Hagan, Lauren Alex and Kenalemang-Palm, Lame Maatla}, year = {2025}, journal = {Critical Studies in Fashion & Beauty}, volume = {16}, number = {2}, pages = {171--195}, doi = {10.1386/csfb_00098_1}, url = {2028971}, language = {eng}, publisher = {Intellect Ltd.}, keywords = {women; ageing; beauty; skin; health; multimodal critical discourse analysis}, abstract = {This article explores gender bias in NIVEA (R) sunscreen advertisements through a transhistorical lens, using multimodal critical discourse analysis to interrogate their linguistic and semiotic features and how these shape discourses around health and beauty. Comparing historical advertisements (1931-61) in the Swedish newspaper Svenska Dagbladet with contemporary advertisements (2015-23) on NIVEA (R)'s Swedish Instagram and website, it identifies three core themes: Sexualization and Beauty; Scientific Rationality; and Shifting Functions, Formulations and Usages. The analysis reveals that sunscreen marketing has long been tied to feminine beauty, with advertisements employing pseudoscientific claims to encourage women to protect their skin and avoid premature ageing. Both past and present advertisements emphasize personal and collective responsibility, reinforcing neo-liberal ideals of bodily self-management. Although contemporary advertisements portray women as slightly more empowered, they still uphold idealized standards of feminine beauty, positioning sunscreen as an essential everyday product for maintaining youth. This study advocates for marketing strategies that frame sunscreen as a universal health necessity, with diverse representations and practical use cases, and calls for stricter regulations to address misleading visual and semiotic elements in advertising.}, issn = {2040-4417} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_westberggustav_2025_1, title = {The generic uniqueness of AI imagery : A critical approach to Dall-E as semiotic technology}, author = {Westberg, Gustav and Kvåle, Gunhild}, year = {2025}, journal = {Discourse & Society}, volume = {36}, number = {4}, pages = {575--598}, doi = {10.1177/09579265241274788}, url = {1897231}, language = {eng}, publisher = {Sage Publications}, keywords = {ai images; digital technologies; diversity; generative ai; multimodal critical discourse analysis; multimodality; promotional culture; semiotic technology; teens}, abstract = {This article addresses a major change emerging in visual communication worldwide: The advent of generative AI imagery. Rooted in Multimodal Critical Discourse Studies and Semiotic Technology Studies, the article scrutinizes how AI-generated images exert power with regards to the meaning-making choices that are afforded by Open AI’s software for generating visuals: Dall-E3. Using prompts to generate images of teenagers as a case in point, the results revealed that the “the canonical repertoire” of generative AI imagery constitutes four main semiotic principles, which are critically explored and discussed: Authenticating Contextualization, Conformist Diversity, Innovative Surrealization, and Promotional Positivity.}, issn = {0957-9265}, file = {https://oru.diva-portal.org/smash/get/diva2:1897231/FULLTEXT01.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_fustfornaf_2025, title = {The Gourmet Tourist}, author = {Fusté-Fornéa, F. and Leer, Jonatan}, year = {2025}, pages = {85--95}, doi = {10.1108/978-1-83549-085-320251009}, url = {2029783}, language = {eng}, publisher = {Emerald Group Publishing Ltd.}, keywords = {copenhagen; denmark; gastronomy; luxury; michelin; tourism}, abstract = {This chapter explores the gourmet tourist as a food tourist profile that seeks a fine dining experience in the context of ‘experiential luxury’. The growing role of luxury experiences in gastronomic tourism has positioned luxury restaurants as culinary ambassadors that influence food tourist behaviour. Based on the case of four Michelin-starred restaurants in Copenhagen (Denmark), results show that the gourmet tourist food experiences as seen by the restaurateurs are driven by three factors. Firstly, the source of the product and the stories behind the product. Secondly, the gourmet experience as a learning process. Thirdly, the memories embedded in the fine dining experience which rely both on people (the staff) and practices (the singularity). © 2025 Francesc Fusté-Forné and Erik Wolf.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_maenejaron_2025_1, title = {The Gradient of Algebraic Model Counting}, author = {Maene, Jaron and De Raedt, Luc}, year = {2025}, volume = {39}, pages = {19367--19377}, doi = {10.1609/aaai.v39i18.34132}, url = {1988740}, language = {eng}, publisher = {AAAI Press}, abstract = {Algebraic model counting unifies many inference tasks on logic formulas by exploiting semirings. Rather than focusing on inference, we consider learning, especially in statistical-relational and neurosymbolic AI, which combine logical, probabilistic and neural representations. Concretely, we show that the very same semiring perspective of algebraic model counting also applies to learning. This allows us to unify various learning algorithms by generalizing gradients and backpropagation to different semirings. Furthermore, we show how cancellation and ordering properties of a semiring can be exploited for more memory-efficient backpropagation. This allows us to obtain some interesting variations of state-of-the-art gradient-based optimisation methods for probabilistic logical models. We also discuss why algebraic model counting on tractable circuits does not lead to more efficient second-order optimization. Empirically, our algebraic backpropagation exhibits considerable speed-ups as compared to existing approaches.Code - https://github.com/ML-KULeuven/amc-grad} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tzierbenjamin_2025, title = {The health promoting sports coach : theoretical background and practical guidance}, author = {Tézier, Benjamin and Barros, Kévin and Geidne, Susanna and Bardid, Farid and Grieco, Spartaco and Johnson, Stacey and Kokko, Sami and Lambe, Barry and Lefebvre, Arthur and Lane, Aoife and Ooms, Linda and Seghers, Jan and Sevdalis, Vassilis and Whiting, Stephen and Vuillemin, Anne and Van-Hoye, Aurélie}, year = {2025}, journal = {BMC Sports Science, Medicine and Rehabilitation}, volume = {17}, number = {1}, doi = {10.1186/s13102-025-01056-y}, url = {1935115}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {action strategies; health promotion; settings-based approach; sports clubs; sports coaches}, abstract = {The sports club setting is a key context for health promotion, but it can also be associated with risky behaviours. Sports coaches play a crucial role in supporting the physical, mental and social health of sport participants but often lack the resources and support to do so. This paper proposes a guide to help coaches become health promoters by aligning their actions with the Health Promoting Sports Club model, which represents the setting-based approach applied to sports clubs. An embedded mixed-method study with a QUAL (qual) design was used, where 15 experts took part in 5 meetings and 299 coaches provided input through an online survey. Four steps were carried out: (1) defining the health-promoting sports coach and key action principles, (2) co-constructing progression stages using the settings-based approach, (3) identifying key actions for promoting health in different moments of coaching (i.e., before, during, and after training and competition, and outside of coaching), and (4) developing long-term intervention components. A definition of the health-promoting sports coach was produced, and eight key action principles have been identified, divided into three dimensions: connection with the system, adoption of a coaching philosophy, and focus on participants. Five stages of progression for integrating health promotion into coaching have been established, ranging from risk prevention to a global approach involving the entire sports system. Specific actions for each moment of coaching (before, during, and after training and competition, and outside of coaching) have been identified, such as monitoring the physical, mental, and social health of participants or plan the coaching session to ensure safety, inclusion, and well-being for all sports participants, staying open for last-minute changes. Finally, long-term intervention components to support the implementation of these actions in practice have been developed, based on what coaches are already doing, the skills they possess and the five stages of progression. This paper enables the development of a guide to help sports coaches promote health by identifying concrete actions and short- and long-term interventions, whilst making links with the health promoting sports club model. It broadens the scope of coaching by incorporating health principles, while emphasising the need to adapt to the environment and context of the club. This work calls for future research to test the effectiveness and feasibility of these approaches in various sporting environments.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_castagnaroalberto_2025, title = {The Hidden Threat in Plain Text : Attacking RAG Data Loaders}, author = {Castagnaro, Alberto and Salviati, Umberto and Conti, Mauro and Pajola, Luca and Pizzi, Simeone}, year = {2025}, pages = {170--181}, doi = {10.1145/3733799.3762976}, url = {2041892}, language = {eng}, publisher = {Association for Computing Machinery (ACM)}, keywords = {retrieval augmented generation; rag; large language models; llm; ai security; llm security; document poisoning; knowledge base poisoning}, abstract = {Large Language Models (LLMs) have transformed human-machine interaction since ChatGPT's 2022 debut, with Retrieval-Augmented Generation (RAG) emerging as a key framework that enhances LLM outputs by integrating external knowledge. However, RAG's reliance on ingesting external documents introduces new vulnerabilities. This paper exposes a critical security gap at the data loading stage, where malicious actors can stealthily corrupt RAG pipelines by exploiting document ingestion.We propose a taxonomy of 9 knowledge-based poisoning attacks and introduce two novel threat vectors-Content Obfuscation and Content Injection-targeting common formats (DOCX, HTML, PDF). Using an automated toolkit implementing 19 stealthy injection techniques, we test five popular data loaders, finding a 74.4% attack success rate across 357 scenarios. We further validate these threats on six end-to-end RAG systems-including white-box pipelines and black-box services like NotebookLM and OpenAI Assistants-demonstrating high success rates and critical vulnerabilities that bypass filters and silently compromise output integrity. Our results emphasize the urgent need to secure the document ingestion process in RAG systems against covert content manipulations.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sandngustav_2025_1, title = {The impact of defunctioning ileostomies on postoperative kidney function in rectal cancer surgery}, author = {Sandén, Gustav and Hed Myrberg, Ida and Boman, Sol Erika and Nordenvall, Caroline and Carrero, Juan-Jesus and Matthiessen, Peter and Rutegård, Martin}, year = {2025}, journal = {Colorectal Disease}, volume = {27}, number = {12}, doi = {10.1111/codi.70329}, url = {2023859}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {anastomotic leakage; defunctioning ileostomy; dehydration; kidney disease; rectal cancer}, abstract = {AIM: To investigate short- and long-term kidney injury incidence in patients undergoing low anterior resection for rectal cancer, comparing those with and without a defunctioning ileostomy.METHOD: We identified all Swedish rectal cancer patients ≤80 years old, with ASA fitness grade ≤III and tumour height ≤12 cm from the anal verge, who underwent anterior resection between 2007 and 2021 using CRCBaSe, a nationwide registry linkage. Patients who received a defunctioning ileostomy during surgery were compared with those who did not. Outcomes included chronic kidney failure, chronic kidney disease, acute kidney injury, and dehydration. Cox proportional hazards models were fitted for each outcome, using overlap weights derived from propensity scores for receiving a defunctioning ileostomy. Stoma reversal impact and mediation by anastomotic leakage were also examined.RESULTS: Among 5286 patients, 4623 (87%) received a defunctioning ileostomy and 663 (13%) did not. A defunctioning ileostomy was not significantly associated with chronic kidney failure (HR 1.68, 95% CI: 0.19-15.16) or chronic kidney disease (HR 1.65, 95% CI: 0.91-2.98) but increased risks of acute kidney injury (HR 3.01, 95% CI: 1.61-5.64) and dehydration (HR 4.02, 95% CI: 2.33-6.94). Risks declined after stoma reversal. Stomas reduced anastomotic leakage with negligible mediation effects on short-term kidney damage.CONCLUSION: A defunctioning ileostomy after low anterior resection increases the risks of acute kidney injury and dehydration but not chronic kidney failure or chronic kidney disease. These risks decrease following stoma reversal, highlighting the need for careful perioperative management.}, issn = {1462-8910} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fornaromarco_2025, title = {The impact of multimorbidity on Quality of Life in inflammatory myopathies : A cluster analysis from the COVAD dataset}, author = {Fornaro, Marco and Venerito, Vincenzo and Pellico, Maria Rosa and Iannone, Florenzo and Joshi, Mrudula and Chen, Yi-Ming and Tan, Ai Lyn and Saha, Sreoshy and Chatterjee, Tulika and Agarwal, Vishwesh and Shinjo, Samuel Katsuyuki and Hoff, Leonardo Santos and Kadam, Esha and Ziade, Nelly and Velikova, Tsvetelina and Hasan, A. T. M. Tanveer and Shumnalieva, Russka and Milchert, Marcin and Tan, Chou Luan and Edgar Gracia-Ramos, Abraham and Cavagna, Lorenzo and Vaidya, Binit and Kuwana, Masataka and Sazliyana Shaharir, Syahrul and Knitza, Johannes and Makol, Ashima and Zamora Tehozol, Erick Adrian and Rojas Serrano, Jorge and Halabi, Hussein and Dey, Dzifa and Toro Gutierrez, Carlos Enrique and Akawatcharangura Goo, Phonpen and Caballero Uribe, Carlo Vinicio and Distler, Oliver and Katchamart, Wanruchada and Day, Jessica and Parodis, Ioannis and Nikiphorou, Elena and Chinoy, Hector and Agarwal, Vikas and Gupta, Latika}, year = {2025}, journal = {Rheumatology}, volume = {64}, number = {4}, pages = {2133--2142}, doi = {10.1093/rheumatology/keae520}, url = {1901811}, language = {eng}, publisher = {Oxford University Press}, keywords = {observational studies; autoinflammatory condition; comorbidity; myositis; quality of life}, abstract = {OBJECTIVE: The presence of comorbidities can substantially affect patients' quality of life, but data regarding their impact on idiopathic inflammatory myopathies (IIMs) are limited.METHODS: We examined the prevalence of comorbidities in IIM patients, other autoimmune rheumatic diseases (oAIRDs), and healthy controls (HCs), using data from the self-reported COVAD-2 survey. We defined Basic Multimorbidity (BM) as the presence of ≥ 2 non-rheumatic chronic conditions and Complex Multimorbidity (CM) as the presence of ≥ 3 non-rheumatic chronic conditions affecting ≥3 organ systems. Hierarchical Clustering on Principal Components was performed for grouping.RESULTS: Among the COVAD respondents, 1558 IIMs, 4591 oAIRDs, and 3652 HCs were analysed. IIMs exhibited a high burden of comorbidities (OR: 1.62 vs oAIRDs and 2.95 vs HCs, p< 0.01), BM (OR 1.66 vs oAIRDs and 3.52 vs HCs, p< 0.01), CM (OR: 1.69 vs AIRDs and 6.23 vs HCs, p< 0.01), and mental health disorders (MHDs) (OR 1.33 vs oAIRDs and 2.63 vs HCs, p< 0.01). Among the IIM patients, those with comorbidities or MHDs had lower PROMIS Global Physical (PGP), PROMIS Global Mental (PGM), and PROMIS Physical Function (SF10) scores, and higher fatigue (F4a) scores (all p< 0.001). PGP, PGM, SF10a and F4a were influenced by age, active disease, BM, and MHDs. Four distinct clusters were identified among the IIMs according to comorbidities and PROMIS scores.CONCLUSION: Patients with IIMs have a higher burden of comorbidities that influence physical and mental health, identifiable as clinical clusters for optimized and holistic management approaches.}, issn = {1462-0324} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_granathannika_2025_2, title = {THE IMPACT ON QUALITY OF LIFE, PSYCHOLOGICAL WELL-BEING AND FATIGUE : A COMPARISON BETWEEN PATIENTS WITH VASCULITIS}, author = {Granath, Annika and Brolin, S. and Dahlberg, Karuna and Gunnarsson, I. and Welin, Elisabet and Pettersson, S.}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {84}, number = {Suppl. 1}, pages = {1619--1619}, doi = {10.1016/j.ard.2025.06.1026}, url = {1989032}, language = {eng}, publisher = {Elsevier}, keywords = {patient reported outcome measures; quality of life}, abstract = {Background: Antineutrophil cytoplasmic antibody associated vasculitis (AAV), which includes Granulomatosis with Polyangiitis (GPA), Microscopic Polyangiitis (MPA), and Eosinophilic Granulomatosis with Polyangiitis (EGPA) are diseases which can cause patients to experience impaired Health-Related Quality of Life (HRQoL), higher levels of anxiety, depression, and fatigue throughout life.Objectives: The aim of this study is to explore patient reported HRQoL, anxiety, depression and fatigue among persons with AAV from different perspectives: Compare levels of HRQoL, anxiety, depression, fatigue and disease characteristics; Describe associations between disease characteristics and HRQoL, anxiety, depression and fatigue; Explore clusters of HRQoL, anxiety and depression.Methods: This cross-sectional cohort study included adults with new and established diagnose of AAV. Anxiety and depression were assessed with Hospital Anxiety and Depression Score, e.g., HADS anxiety (HADS-A), and HADS-depression (HADS-D). HRQoL was assessed with EQ-5D-3L (EQ-5D-index), EQ-Visual analogue scale, (EQ-VAS), fatigue by Multidimensional assessment of Fatigue, (MAF). Disease activity was measured by Birmingham Vasculitis Activity Score (BVAS), scores ≥ 1 was defined as active disease. Disease duration ≤ 2 years was considered short disease duration. Mann-Whitney U-test and Kruskal Wallis H-test was used where appropriate to compare distributions between groups of patients. Bivariate correlations were analysed with Spearman's rank-order correlation. A hierarchical cluster analysis was performed, based on EQ-5D-index, EQ-VAS, HADS-A and HADS-D.Results: 296 patients were included, equally distributed between women; 157 (53%) and men; 139 (57%), with a mean age of 59 years (SD 15.6, range 18-90). Two hundred and nine had GPA (70,6%), 75 had MPA (25,3%), and twelve had EGPA (4,1%). Mean disease duration was 4.2 years (SD 5.5, range 0-31). 55% of patients had a disease duration of ≤ 2 years, and 45% ≥ 3 years, and mean BVAS score was 6.3 (SD 8.68, range 0-33). Distributions of EQ-5D-index, EQ-VAS, HADS-A, HADS-D and MAF were similar for all three AAV diagnosis (p=0.35 - 0.69). HADS-A was higher in females, patients with active disease, and patients with short disease duration (p=0.001 - 0.013). EQ-5D-index was higher in patients with inactive disease (p=0.014). EQ-VAS was higher in patients with inactive disease, long disease duration and age > 65 years (p=0.005 - 0.017). MAF was higher in patients with active disease, short disease duration and < 65 years old (p=0.03 - 0.05). Weak associations were found among all patients between disease activity respective disease duration and EQ-VAS, MAF, HADS-A and HADS-D (rs -0.279 - 0.286). Among patients with EGPA, a moderate negative association (rs -0.736) between disease activity and EQ-5D-index, moderate positive (rs 0.579) association between disease duration and EQ-VAS, and a moderate negative association between disease duration and MAF (rs -0.699) was observed. Four clusters were identified based on EQ-5D-index, EQ-VAS, HADS-A and HADS-D. A: Low HRQoL, mild anxiety/depression, high disease activity and short disease duration. B: High HRQoL, no anxiety/depression, no disease activity and long disease duration. C: Moderate HRQoL, mild anxiety/depression low disease activity and short disease duration. D: Moderate to high HRQoL, no anxiety/depression, no disease activity and longer disease duration. All four clusters had similar distributions between women, men, and age, and the three diagnoses were represented in each of the four clusters (Table 1).Conclusion: In this study we evaluated the impact of AAV on patients HRQoL, psychological well-being and fatigue. Disease activity, disease duration, gender and age affected HRQoL, anxiety, depression, and fatigue. In the small group of EGPA strong associations were found between HRQoL measured with EQ-index, and BVAS, as well as between HRQoL measured with EQ-VAS, fatigue and disease duration. The cluster analysis describes the impact of AAV on a person's life in different stages of the disease, which highlights the continuous need for multi professional care during the disease course. Interestingly, in this study it appears that EQ-VAS better distinguish levels of HRQoL, than EQ-5D-index, which should be further investigated.}, issn = {0003-4967} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_harrisonkatherine_2025, title = {The Imperfectly Relatable Robot : An Interdisciplinary Approach to Failures in Human-Robot Relations}, author = {Harrison, Katherine and Somasundaram, Kavyaa and Loutfi, Amy}, year = {2025}, pages = {141--164}, doi = {10.7551/mitpress/15314.003.0009}, url = {2039455}, language = {eng}, publisher = {MIT Press} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_shawdavid_2025, title = {The importance of microbiology reference laboratories and adequate funding for infectious disease surveillance}, author = {Shaw, David and Jacobsson, Susanne and Mölling, Paula and Brueggemann, Angela B.}, year = {2025}, journal = {The Lancet Digital Health}, volume = {7}, number = {4}, pages = {e275--e281}, doi = {10.1016/S2589-7500(24)00241-3}, url = {1926371}, language = {eng}, publisher = {Elsevier}, abstract = {Microbiology reference laboratories perform a crucial role within public health systems. This role was especially evident during the COVID-19 pandemic. In this Viewpoint, we emphasise the importance of microbiology reference laboratories and highlight the types of digital data and expertise they provide, which benefit national and international public health. We also highlight the value of surveillance initiatives among collaborative international partners, who work together to share, analyse, and interpret data, and then disseminate their findings in a timely manner. Microbiology reference laboratories have substantial impact at regional, national, and international levels, and sustained support for these laboratories is essential for public health in both pandemic and non-pandemic times.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hgsnesmonika_2025, title = {The Importance of the Hospital Social Worker's Psychosocial Support in Brain Injury Rehabilitation : An Interview Study with Individuals with Acquired Brain Injury and their Close Relatives}, author = {Högsnes, Monika and Grim, Katarina and Udo, Camilla and Landstedt, Evelina and Ullsten, Alexandra}, year = {2025}, journal = {Brain Injury}, volume = {39}, number = {Suppl. 1}, pages = {S104--S104}, url = {2036845}, language = {eng}, publisher = {Taylor & Francis}, keywords = {acquired brain injury; psychosocial support; hospital social worker; user perspective}, abstract = {Acquired brain injury (ABI) is a life-changing experience for the individuals and their close relatives. Psychosocial support is critical in helping individuals adapt to and cope with the new conditions following a brain injury. However, knowledge about the different components of psychosocial support and their impact on people with acquired brain injury is limited. The aim of this interview study is to develop knowledge about important aspects of psychosocial support in the Swedish health care system by exploring the experiences and perceptions of people with ABI and their close relatives. Participants were aged 18 years and older, and had met with a hospital social worker at least twice. Semi structured interviews were conducted with twenty-three individuals with acquired brain injury and ten interviews with close relatives. The interviews were analyzed using qualitative content analysis. Preliminary findings indicate the importance of person-centered psychosocial support at different stages of brain injury rehabilitation. Participants share a wide range of experiences of accessing and shaping of the psychosocial support. Participants in this study experience a need for hospital social workers who know the common characteristics of having an ABI, but who are also interested in the person on a personal level. The participants is in need of psychosocial support with different designs, especially crisis support, supportive counselling, counselling for the close relatives, information and some practical help. Preliminary findings also indicate a need of a distinct way to access psychosocial support when needed. }, issn = {0269-9052} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_websternatashaa_2025_4, title = {The Importance of Thinking In-Place with ‘Vulnerable’ Neighbourhoods for Policy Making}, author = {Webster, Natasha A. and Veen, Esther and Johansson, Sofi}, year = {2025}, journal = {Cosmopolitan Civil Societies: An Interdisciplinary Journal}, volume = {17}, number = {1}, pages = {95--107}, doi = {10.5130/ccs.v17.i1.9336}, url = {1950868}, language = {eng}, publisher = {Cosmopolitan Civil Societies Research Centre}, keywords = {in-place knowledge; decision-makers; sustainable policy; neighbourhood; context}, abstract = {Big data are increasingly being used to understand complex social and economic challenges. While there is much to be learned from such approaches, in-place data remain necessary for a multidimensional understanding of neighbourhoods, and for sustainable and socially just policies. Rather than reinforcing methodological divides, the argument we set forth in this paper is that multiple forms and strands of inquiry illuminate complexities of space, place and community. Decision makers should consider how and why they may privilege certain forms of data, and instead tap into diversified ways of knowing. We reflect on the challenges and opportunities of crafting in-place data as a relational process integral for decision makers and policymaking. To do so, we discuss two case studies in Sweden and The Netherlands that demonstrate the importance of widening the scope of knowledge, and a willingness to decentre singularity and homogenous definitions of community and place.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_kroonsa_2025_2, title = {The (ir)relevance of Aida for broadcast talk research}, author = {Kroon, Åsa}, year = {2025}, url = {2037240}, language = {eng}, keywords = {ai; broadcast talk; sociability; sports journalism; televised sports}, abstract = {On 6 April 2025, a presenter of a live football match event aired by the streaming service Max Sport Sweden introduced their new expert commentator Aida to the show. The expert Aida turned out to be an AI agent designed as a talkative woman in her thirties with long blonde, wavy hair and spectacles. As Aida came into view alongside the live female presenter in a split screen, she presently began explaining how she was to provide “objective analyses” of the Swedish football teams during the season. In a rather awkward attempt at “interacting” with the pre-edited Aida, the presenter worked at establishing some kind of discursive and social bond with Aida for the audience’s benefit, an action that resulted in simultaneous talk and unsynchronized gestures. Max Sport Sweden’s first attempt at integrating Aida in their live sportscasts raises interesting questions related to the development of broadcast talk research . These questions will be addressed in this paper using the introduction of Aida as an illustrative example.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jamesinger_2025, title = {The journey of discovery in co-creating knowledge to find a new way of working in municipal home care-seven lessons learned in a participatory appreciative action and reflection study}, author = {James, Inger and Kihlgren, Annica and Tavemark, Sofia}, year = {2025}, journal = {Health Psychology and Behavioral Medicine}, volume = {13}, number = {1}, doi = {10.1080/21642850.2025.2534624}, url = {1989222}, language = {eng}, publisher = {Taylor & Francis}, keywords = {fieldwork; co-creating knowledge; homecare; individual goal; participatory research; relationship}, abstract = {Purpose: The study is part of a larger structural change programme, where Participatory Appreciative Action and Reflection (PAAR) has been used with the aim of changing home care practices to align with individuals' needs and goals. The purpose of this study was to describe how the knowledge process in PAAR was conducted to develop a new way of working based on the individual's needs and goals in home care.Method: A total of 160 co-researchers i.e. older persons, relatives, staff, administrators, first-line managers, case managers and persons from the authority were included in the study. Data was collected through fieldwork, including interviews, participant observations, informal conversations, focus group discussions, reference groups, and appreciative inquiry circles.Results: Co-creating knowledge was revealed as a three-step process: preparation for access to the field, being together in the field, and leaving the field. Each step describes several cycles of how the PAAR process proceeded, with actions leading to reflections and vice versa, which drove the knowledge process forward.Conclusions: The knowledge process of PAAR, gave rise to seven lessons learnt for future practice development: Contact pathways and trusting relationships, Loving struggle over time, An appreciative gaze, Patience and courage, Different ways of learning, A shared goal and Flexibility to adapt PAAR to changes in the field.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_primusroberts_2025_2, title = {The landscape of performance analysis technology in Swedish elite football}, author = {Primus, Robert S. and Karlsson, Martin}, year = {2025}, journal = {International Journal of Performance Analysis in Sport}, doi = {10.1080/24748668.2025.2582296}, url = {2014745}, language = {eng}, publisher = {Routledge}, keywords = {performance analysis; technology; swedish elite football}, abstract = {In recent decades, new technologies for tracking and analysing athletes' performance have emerged, primarily adopted by financially strong clubs in major men's team sport leagues. However, diffusion is now more widespread. While previous research highlights both benefits and drawbacks of these technologies, it has largely focused on men's sports within the Anglosphere. This study aims to provide an overview of the use of performance analysis technologies in Swedish men's and women's elite football. Findings from the online survey show that while uptake is higher in men's football and in the top divisions, over 80% of the respondents report that their clubs use one or more forms of technology. Video analysis is the most common, followed by GPS and mobile apps. Strength and conditioning coaches play a central role in implementation, whereas players are rarely involved in data processing. Drawing on previous research, unlocking the potential of big data and avoiding digital divides requires that Swedish club management allocate sufficient resources and equip stakeholders not only with technological competence but also with pedagogical and communication skills. However, to provide more specific recommendations, further research is needed on the implementation phase and on how stakeholders, particularly players, experience the use of performance analysis technologies.}, issn = {2474-8668} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_ervolaura_2025_5, title = {The language of the defence : Communication in Finnish courts}, author = {Ervo, Laura}, year = {2025}, pages = {417--446}, url = {2015792}, language = {eng}, publisher = {Mouton de Gruyter} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_16, title = {The Limits of Family Abolition}, author = {Johansson Wilén, Evelina}, year = {2025}, journal = {Jacobin}, url = {1978727}, language = {eng}, publisher = {Jacobin Press}, issn = {2470-6930} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_forsstenmaximilianpeter_2025_3, title = {The MangLE score : A novel simple tool to identify patients who are unlikely to require amputation following severe lower extremity injury}, author = {Forssten, Maximilian Peter and Coimbra, Bruno and Matecki, Mary and Godshall, Saundra and Cao, Yang and Mohseni, Shahin and Sarani, Babak}, year = {2025}, journal = {Journal of Trauma and Acute Care Surgery}, volume = {98}, number = {1}, pages = {160--166}, doi = {10.1097/TA.0000000000004453}, url = {1913481}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, keywords = {amputation; mangled extremity; crush}, abstract = {BACKGROUND: There are no validated and sensitive models that can guide the decision regarding amputation in patients with mangled lower extremities. We sought to describe a simple scoring model, the Mangled Lower Extremity (MangLE) score, which can predict those who are highly unlikely to need an amputation as a means to direct resources to this cohort.METHODS: This is a retrospective study using the 2013-2021 American College of Surgeons Trauma Quality Improvement Program data set. Adult patients with a mangled lower extremity, defined as a crush injury or a fracture of the femur or tibia combined with severe soft tissue injury, arterial injury, or nerve injury, were included. Patients who suffered a traumatic lower extremity amputation, underwent amputation within 24 hours of admission, or who died within 24 hours of admission were excluded. Patients were divided into those who did/did not undergo amputation during their hospital stay. Demographics, injury mechanism, Injury Severity Score, and Abbreviated Injury Scale score, initial vital signs, and comorbid conditions were abstracted. A logistic regression model was constructed and the top five most important variables were used to create the score.RESULTS: The study includes 107,620 patients, of whom 2,711 (2.5%) underwent amputation. The five variables with the highest predictive value for amputation were arterial injury, lower-extremity Abbreviated Injury Scale score of ≥3, crush injury, blunt mechanism, and shock index. The lowest possible MangLE score was 0, and the highest was 15. The model demonstrated an excellent predictive ability for lower extremity amputation in both the development and validation data set with an area under the receiver operating characteristic curve of 0.81 (95% confidence interval, 0.80-0.82) and 0.82 (95% confidence interval, 0.81-0.84), respectively. The negative predictive value for a score of <8 is 99%.CONCLUSION: The MangLE score is able to identify patients who are unlikely to require amputation. Resources for limb salvage can be directed to this cohort.LEVEL OF EVIDENCE: Prospective and Epidemiologic; Level IV.}, issn = {2163-0755} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_berglezpeter_2025_4, title = {The mediatedness of interorganizational collaboration : How collaboration materializes through affordances, chains, and switches}, author = {Berglez, Peter and Hedenmo, Otto}, year = {2025}, journal = {Organization}, volume = {32}, number = {1}, pages = {9--29}, doi = {10.1177/13505084231187335}, url = {1784533}, language = {eng}, publisher = {Sage Publications}, keywords = {affordances; cco; communication; digital; interorganizational collaboration; media; organizations}, abstract = {In research into interorganizational collaboration (IOC), the number of contributions highlighting the constitutive role of communication constantly seems to increase. However, surprisingly few contributions are devoted to communication studies that concentrate on the use of different media. An advanced “mediatedness” perspective is increasingly required, not least in terms of theory, focusing on how different media, as objects, tools and agents altogether constitute collaboration through complex combinations and asymmetric usage patterns. Therefore, the purpose of this article is to develop a theoretical framework for analyzing IOCs as media-driven processes and practices, which is highly relational. Of particular importance are the diachronic transformations of meaning-making when discursive content (sketchy notes, brainstorming, digital threads, presentation program slides, etc.) is transferred and materialized into stable ideas, proposals or solutions; moving from one media context to another; and its impact on the collaborations’ outcome.}, issn = {1350-5084} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_javedfarrukh_2025, title = {The method of moments for multivariate random sums in the Poisson-Skew-Normal case}, author = {Javed, Farrukh and Loperfido, Nicola and Mazur, Stepan}, year = {2025}, journal = {Statistics and Probability Letters}, volume = {219}, doi = {10.1016/j.spl.2024.110338}, url = {1921800}, language = {eng}, publisher = {Elsevier}, keywords = {fourth cumulant; kurtosis poisson distribution; skew-normal distribution}, abstract = {Multivariate random sums appear in many scientific fields, most notably in actuarial science, where they model both the number of claims and their sizes. Unfortunately, they pose severe inferential problems. For example, their density function is analytically intractable, in the general case, thus preventing likelihood inference. In this paper, we address the problem by the method of moments, under the assumption that the claim size and the claim number have a multivariate skew-normal and a Poisson distribution, respectively. In doing so, we also derive closed-form expressions for some fundamental measures of multivariate kurtosis and highlight some limitations of both projection pursuit and invariant coordinate selection.}, issn = {0167-7152} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_govorovigor_2025, title = {The microbiome in endometrial cancer : vaginal milieu matters}, author = {Govorov, Igor and Komlichenko, Eduard and Ulrikh, Elena and Dikareva, Elena and Pervunina, Tatiana and Vazhenina, Oksana and Dzharbaeva, Amina and Kalinina, Olga and Zaikova, Ekaterina and Razumova, Zoia and Mints, Miriam and Sitkin, Stanislav}, year = {2025}, journal = {Frontiers in Medicine}, volume = {12}, doi = {10.3389/fmed.2025.1533344}, url = {1961994}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {endometrial cancer; microbiota; endometrial microbiota; endometrial hyperplasia; carcinogenesis; vaginal microbiota}, abstract = {Endometrial cancer remains one of the most common malignancies in women, and its incidence is particularly increasing in developed countries. Despite the well-known promotive role of excessive exposure to estrogen, many other details of the pathogenesis of endometrial cancer remain unknown. Recent studies have elucidated the emerging role of the resident microbiota in the progression of various diseases, including cancer. Next-generation sequencing demonstrated that the uterine cavity, previously considered sterile, contains a composition-rich microbiota. In this work, we determined the differences in the composition of the intrauterine microbiota between patients with endometrial cancer and its precursor-endometrial hyperplasia.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_wurmmatilda_2025_2, title = {The minority stress and minority joy model : The development of a model for practitioners meeting transgender and gender diverse people.}, author = {Wurm, Matilda and Lundberg, Tove and Malmquist, Anna}, year = {2025}, url = {2042406}, language = {eng}, keywords = {gender minority joy model; minority joy and stress model; lgbtq+; minority stress; transgender and gender-diverse}, abstract = {Introduction: Professional meetings are highly influenced by the practitioner’s previous knowledge and personal values. Previous research with transgender and gender diverse (TGD) people, has emphasized negative aspects. This damage-focused approach is problematic. For practitioners, there is a risk of being overly cautious when meeting TGD clients and of missing strengths at assessment. The aim of this study is to integrate positive aspects into minority stress theory by first formulating a minority joy model depicting positive aspects present in TGD lives, and second, combining this model with the minority stress model to create the minority joy and stress model.Method: Literature on the minority stress and the gender minority stress and resilience model, as well as literature on positive aspects of being TGD are reviewed, discussed, and used to create the models.Results: The gender minority joy model addresses positive TGD experiences and their unique influence on wellbeing. The minority joy and stress model gives a broad overview of aspects to assess when meeting people from minoritized groups and clarifies how both joy and stress influences health and wellbeing.Conclusion: The model can aid practitioners in assessing both risks and strengths leading to better outcomes for their clients.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_segerkarin_2025, title = {The Modern History and the Changing Nature of Audit Regulation : The Case of Sweden}, author = {Seger, Karin and Frostenson, Magnus and Helin, Sven}, year = {2025}, journal = {International Journal of Auditing}, volume = {29}, number = {4}, pages = {613--630}, doi = {10.1111/ijau.12388}, url = {1973028}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {auditing; auditors; conventional regulation; meta-regulation; professional regulation; professional self-regulation; regulation; regulatory development; self-regulation; sweden; transnational regulation}, abstract = {The aim of this article is to describe and explain how developments from the 1980s to 2024 have changed the nature of audit regulation. To this end, the article draws on central concepts from regulatory literature. The Swedish case is used as an example, with a historical review based on data from parliamentary documents and articles published in the Swedish trade magazine Balans. The empirical findings show that the regulatory developments since the 1980s can be divided into three different eras, each spanning 15 years. The first era is characterised by professional self-regulation supplemented by some conventional regulation. The second era is marked by meta-regulation following Sweden's membership in the EU. In the third era, self-regulation is largely replaced by alternative regulatory approaches. The conclusion is that parallel regulatory approaches coexist and shape various forms of regulation and that regulative change can be explained by institutional developments, internationalisation and normative expectations.}, issn = {1090-6738} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_druggedaniel_2025, title = {The money illusion and democratic accountability : the democratic stakes of indexing government benefits}, author = {Drugge, Daniel}, year = {2025}, journal = {European Political Science}, volume = {24}, number = {4}, pages = {654--669}, doi = {10.1057/s41304-025-00522-y}, url = {1953481}, language = {eng}, publisher = {Palgrave Macmillan}, keywords = {indexation; democratic accountability; money illusion; welfare state retrenchment}, abstract = {The decision whether to index government benefits can have significant economic and political implications. It can affect whether or to what extent benefits maintain their real value over time, affect the policy levers available to fight inflation, and shape discretionary budget priorities. Most of the attention in the literature has focused on understanding the economic pros and cons of indexing and the politics and political use of indexation in the context of welfare state reform and retrenchment. Less attention has been paid to what indexation means for democratic accountability. This paper seeks to rectify this by investigating the democratic stakes of indexing government benefits. It argues that there are, other things being equal, strong democratic reasons to index government benefits in a way (or according to metric) that preserves their publicly articulated purpose. However, concerns about lack of discretion and ownership suggest indexation rules should be designed to provide governments with some discretionary power over the size and perhaps timing of automatic adjustments-though accompanied by requirements that the exercise of this discretionary power be justified publicly.}, issn = {1680-4333} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_yikjason_2025, title = {The neurobench framework for benchmarking neuromorphic computing algorithms and systems}, author = {Yik, Jason and Kleyko, Denis and Reddi, Vijay Janapa}, year = {2025}, journal = {Nature Communications}, volume = {16}, number = {1}, doi = {10.1038/s41467-025-56739-4}, url = {1936875}, language = {eng}, publisher = {Springer}, abstract = {Neuromorphic computing shows promise for advancing computing efficiency and capabilities of AI applications using brain-inspired principles. However, the neuromorphic research field currently lacks standardized benchmarks, making it difficult to accurately measure technological advancements, compare performance with conventional methods, and identify promising future research directions. This article presents NeuroBench, a benchmark framework for neuromorphic algorithms and systems, which is collaboratively designed from an open community of researchers across industry and academia. NeuroBench introduces a common set of tools and systematic methodology for inclusive benchmark measurement, delivering an objective reference framework for quantifying neuromorphic approaches in both hardware-independent and hardware-dependent settings. For latest project updates, visit the project website ( neurobench.ai ).} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_grosingerherminej_2025, title = {The Next Level of Long-Term Agent Autonomy - Proactively Acquiring Knowledge and Abilities}, author = {Grosinger, Hermine J.}, year = {2025}, pages = {2859--2864}, url = {1999401}, language = {eng}, publisher = {International Foundation for Autonomous Agents and Multiagent Systems}, keywords = {proactivity; autonomy; human-ai systems; long-term real-world agents; epistemic reasoning; ability}, abstract = {For an artificial agent operating long-term under real-world conditions it is not enough to be able to act on orders given by the human. Even being able to act proactively (anticipatory, self-initiated) does not suffice. The reason roots in the unrealistic assumption that the proactive agent from the start and always knows everything it needs to know and has all the abilities it requires. We argue that the agent has to be able to proactively learn new knowledge and abilities according to how the dynamic environment evolves. We identify challenges and directions towards proactive learning. Our focus is on formal methods which lend themselves to doing the necessary reasoning but also give suggestions how these might be integrated with machine learning. The ideas envisioned in this paper can advance (M)AS (Multi-Agent Systems) research and have the potential to enhance collaborations of hybrid human-AI systems.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wemarisabelle_2025, title = {The order of completing MDP and D12 does not affect the breathlessness responses : A randomised controlled trial}, author = {Wemar, Isabelle and Sandberg, Jacob and Olsson, Max and Sundh, Josefin and Ekström, Magnus}, year = {2025}, journal = {Chronic Respiratory Disease}, volume = {22}, doi = {10.1177/14799731251393985}, url = {2010713}, language = {eng}, publisher = {Sage Publications}, keywords = {copd; cardiopulmonary disease; dyspnoea; dyspnoea-12; multidimensional dyspnoea profile; patient-reported outcomes}, abstract = {Background: Breathlessness is a common and distressing symptom across a wide range of medical conditions. Different aspects (dimensions) of breathlessness can be assessed using the Multidimensional Dyspnoea Profile (MDP) and Dyspnoea-12 (D12) questionnaires. We aimed to examine whether the order of completing MDP and D12 affects the breathlessness responses in people with cardiorespiratory disease.Methods: This was a randomised controlled trial embedded within a longitudinal clinical study. Outpatients with cardiorespiratory disease were randomly assigned to either first complete the MDP or the D12. Primary outcome was mean difference in D12 total score between groups, secondary outcome was mean difference in D12 and MDP subdomain scores. Both outcomes were compared to the minimal clinically important difference (MCID) for each scale.Results: All 182 participants from the longitudinal study were included. 93 were randomized to complete MDP first and 89 to D12 first. Characteristics such as age, sex, main cause of breathlessness and smoking status were similar between groups. The mean difference for D12 total score (MCID = 2.8) was -1.5 (-4.2 to 1.3, p = 0.26) between groups. Mean differences between groups in subdomain scores were also below the corresponding MCID.Conclusion: The order of completion of MDP and D12 did not impact the scores significantly, but the study lacked power to find smaller yet clinically significant differences. The study supports that the most practical order of completing the instruments can be used in future research and in clinical settings.}, issn = {1479-9723} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_qandeelmais_2025_7, title = {The Palestinian Environment under Israeli Military Occupation : An International Humanitarian Law Perspective}, author = {Qandeel, Mais}, year = {2025}, pages = {201--238}, url = {1961647}, language = {eng}, publisher = {Graduate Institute Publications}, keywords = {palestinian environment; international humanitarian law; destruction and exploitation of natural resources}, abstract = {The Palestinian environment suffers destruction and degradation under the Israeli long-term military occupation. This chapter addresses three main points of discussion. First, it examines the Israeli practices, namely the destruction and exploitation of natural resources, land contamination and mismanagement of waste, as well as their impact on the Palestinian environment in the occupied Palestinian territory (oPt). Second, the chapter reviews customary and conventional provisions of international humanitarian law that may be applied to protect the environment in the oPt. It also studies related international principles embodied in the Rio Declaration on Environment and Development of 1992. Third, the chapter examines Israel’s responsibility under international law and points out possibilities and challenges in relation to the laws protecting the Palestinian environment. The chapter argues that the protection of the Palestinian environment is not sufficient under relevant international provisions. Thus, there is a need for clear and strict regulations to prevent environmental harm.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindbergdaniel_2025, title = {The Pandemic's Impact on Mental Well-Being in Sweden : A Longitudinal Study on Life Dissatisfaction, Psychological Distress, and Worries}, author = {Lindberg, Daniel and Nilsson, Kent W. and Stier, Jonas and Kerstis, Birgitta}, year = {2025}, journal = {International Journal of Environmental Research and Public Health}, volume = {22}, number = {6}, doi = {10.3390/ijerph22060952}, url = {1977810}, language = {eng}, publisher = {MDPI}, keywords = {covid-19; sweden; life dissatisfaction; longitudinal study; mental health; psychological distress; sex differences; societal expectations; worries}, abstract = {The COVID-19 pandemic has had a profound impact on society, including on physical and mental health. This study investigated changes in mental health parameters among a Swedish sample during and after the pandemic. Using a longitudinal study, we investigated the relationships among life dissatisfaction, psychological distress, and worries, with factors such as age, sex, education, severe illness, and job loss due to the pandemic among 588 men (mean age 54.9 years), and 653 women (mean age 52.9 years). The results reveal sex differences in life dissatisfaction and psychological distress; in addition, younger individuals reported more life dissatisfaction, and psychological distress compared with older groups. Women were 4.5 times more likely than men to report worries in 2021 and 2.3 times more likely in 2022, even after adjusting for age, education, severe illness, and job loss. This study shows how societal expectations and sex roles may exacerbate these differences in mental well-being during a time of crisis. The conclusions emphasize the importance of considering factors such as sex, age, education, and employment status when developing interventions and support systems during a global crisis. The COVID-19 pandemic will continue to affect society for a long time, indicating a need for ongoing research into population-level consequences.}, issn = {1661-7827} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_moenchristianarvei_2025, title = {The past, present and future of penile cancer in the Nordic countries : Results from NORDCAN}, author = {Moen, Christian Arvei and Gerdtsson, Axel and Aagaard, Mikael and Hopland, Andreas and Kirrander, Peter and Jakobsen, Jakob Kristian}, year = {2025}, journal = {BJUI Compass}, volume = {6}, number = {7}, doi = {10.1002/bco2.70041}, url = {1981413}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {nordcan database; incidence; penile cancer; survival; time trends}, abstract = {OBJECTIVES: This work aims to present epidemiological data on penile cancer from the Nordic region (Denmark, Finland, Iceland, Norway, Sweden) and discuss the results in light of the present knowledge and possible future treatment strategies.PATIENTS AND METHODS: All patients diagnosed with penile cancer in the Nordic countries between 2000 and 2022 were identified in the NORDCAN database. Data on the number of new cases per year, incidence (presented as an age-standardized rate using the Nordic population as a reference), prevalence, mortality, relative survival and predictions on the future societal impact of this cancer was retrieved.RESULTS: A total of 6106 cases of penile cancer were registered in a population that increased from about 12-14 million men over the period. The age-standardized incidence has significantly increased over time and is now above 2.0 per 100 000 men. Currently, more than 300 new cases are diagnosed each year, and more than 3000 men live with a penile cancer diagnosis. Mortality, as well as both 1-year and 5-year relative survival have, however, remained nearly unchanged. Using the NORPRED model, it is predicted that the yearly number of penile cancer cases will continue to increase in all the countries investigated over the next decade.CONCLUSION: Penile cancer incidence and prevalence have increased in the Nordic region over the last 20 years. Mortality and survival, however, have remained unchanged. The number of new penile cancer cases is predicted to increase over the next decade. Better treatment options for these patients are therefore urgently needed.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kenalemangpalmlamem_2025, title = {The “perfect” filtered look? A multimodal critical discourse analysis of TikTok #beautyfilters}, author = {Kenalemang-Palm, Lame M. and Eriksson, Göran}, year = {2025}, journal = {Critical Studies in Media Communication}, pages = {1--15}, doi = {10.1080/15295036.2025.2566836}, url = {2006652}, language = {eng}, publisher = {Routledge}, keywords = {beauty filters; digital-forensic gaze; mcda; social semiotics; tiktok}, abstract = {Grounded in the Social Semiotic theory of communication and employing Multimodal Critical Discourse Analysis (MCDA) as its methodological framework, this paper examines the hashtag #beautyfilters to explore how women engage discursively with beauty ideals through their online self-presentations. Beauty filters enable users to manipulate and digitally enhance their own images, shaping how they perceive and construct the self. The data consist of 67 TikTok videos collected during May 2023. From this material, we identified three broad thematic categories: Creating the “perfect” face through filters; beauty tutorials and the “digital-forensic gaze”; and authenticity in self-presentation. The findings suggest that beauty filters intensify a digital-forensic gaze directed at women’s appearances. This gaze compels women to compare their own looks not only to those of others but also with idealized, filter-generated versions of themselves. This pursuit of perfection, sustained by a neoliberal, self-objectifying gaze, encourages women to internalize narrow beauty norms and to perceive their natural appearances as inherently “not good enough.”}, issn = {1529-5036} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_lundahlchristian_2025, title = {The Peripherals of Research Networks : Spouses and family members in comparative education research 1950s-1990s}, author = {Lundahl, Christian}, year = {2025}, pages = {38--38}, url = {1997742}, language = {eng}, abstract = {This paper examines the role of family members – particularly wives – within the extensive correspondence network of international and comparative education scholars documented in the unique archive of Professor Torsten Husén (1916–2009), which comprises over 80,000 pages of letters from the 1950s to the 1990s. Using a Science and Technology Studies (STS) perspective, informed by Donna Haraway’s (1988) concepts of situated knowledges and subjugated standpoints, the paper reveals how these seemingly peripheral figures actively contributed to knowledge production rather than remaining passive bystanders. By combining large language models, close reading, and preliminary network analysis of metadata (senders, recipients, greetings, references), the study shows how mentions of family construct multi-scalar relational structures. Focusing on the often-backgrounded voices at the periphery, the paper challenges traditional academic genealogies and resituates domestic spaces as co-productive sites of intellectual life. These intimate references illuminate overlooked material-semiotic entanglements, showing how wives and family members functioned as connective nodes that shaped correspondence rhythms, emotional tones, logistical support and in the end the circulation of ideas. This approach not only enriches our understanding of large-scale correspondence archives but also aligns with feminist STS calls to amplify marginal and relational perspectives, highlighting the agency of those at the edges of scholarly networks.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_hearnjeff_2025_7, title = {The place and potential of crisis/crises in critical studies on men and masculinities}, author = {Hearn, Jeff}, year = {2025}, pages = {125--151}, url = {2021437}, language = {eng}, publisher = {Bristol University Press}, keywords = {crisis; men; masculinities; polycrisis; global}, abstract = {This article derives from considering the interrelations of two sets of long-term internationa lwork: that on interdisciplinary crisis studies and that on critical studies on men and masculinities. More specifically, it interrogates the place and potential of crisis and crises in the politics and problematics of men and masculinities, including how crisis can be a driver of critical studies on men and masculinities. Further to this, four main forms of deployment of crisis within critical studies on men and masculinities are interrogated. There is a wellelaborated debate on what has come to be called ‘the crisis of masculinity’. Interestingly, this takes very different shapes, sometimes even opposite constructions, in different parts of the world and within different discourses. Even with this diversity, crisis is often presented as ‘fact’, identity and a result of ‘role confusion’ for boys, young men and men around what it might mean to be a boy and man in contemporary times. This approach contrasts with those foregrounding more endogenous crisis tendencies, first, within patriarchal relations and then of gender itself, with associated deconstructions of men and masculinity. Meanwhile, within critical studies on men and masculinities, there has been a relative neglect, at least until recently, of large-scale global crises. Key examples include financial crisis, political crisis, ecological crisis and pandemic crisis. In short, there appears to have been over-recognition of the ‘crisis of masculinity’, some recognition of crisis tendencies of patriarchal relations and of gender, and under-recognition of crises created or reinforced largely by certain men and masculinities globally and transnationally.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_wintonpatrik_2025_1, title = {The political economy of taxation : Bargaining at the meetings of the Swedish riksdag, 1789-1812}, author = {Winton, Patrik}, year = {2025}, pages = {53--75}, doi = {10.4324/9781003469032-4}, url = {1991092}, language = {eng}, publisher = {Routledge}, abstract = {This chapter focuses on political bargaining about taxation in the Swedish riksdag during the period 1789–1812. This was a time when European states faced challenges either to expand their state capabilities or to face the threat of invasion and political change. The analysis focuses on the types of taxes that became objects of political deliberation and the tax rates different social groups were obliged to pay. In order to broaden the perspective on the developments in Sweden, limited comparisons are made with the decisions taken at the same time by the estates of Hungary. The analyses show that the Swedish king increased his political autonomy in the 1770s and 1780s, but it was difficult in the long run to expand the government’s resources without the participation of the riksdag. One difference between Hungary and Sweden was the role government debt played in the political negotiations between the ruler and the estates. While the estates of Hungary had a limited role in this regard, the Swedish riksdag was involved in financing and also in the administration of government debt through its Debt Office. Public debt was therefore a key object of political contestation in Sweden over the course of the period.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_janssonmaria_2025_2, title = {The politics of constructing television audiences : Diversity, equality and inclusion in Swedish media policy}, author = {Jansson, Maria and Van Belle, Jono}, year = {2025}, journal = {Convergence. The International Journal of Research into New Media Technologies}, doi = {10.1177/13548565251388146}, url = {2007671}, language = {eng}, publisher = {Sage Publications}, keywords = {public service; streaming platforms; citizens; consumers; national cohesion; protection of minors; people with disabilities; militarization; nationalism}, abstract = {This article seeks to analyze audience constructions in Swedish policy documents dealing with televised media from 2012 to the present. The period analyzed has been characterized by changes in Swedish media policy due to new technology, neoliberal governing ideas, and globalization. Further, debates about media policy have recently become polarized, and longstanding ideals of diversity, gender equality, and inclusion have been challenged. The article analyzes the political work performed by audience constructions and unpacks the characteristics of spectators in their capacity as citizens, Swedes, consumers, and the protected. The article shows that audience conceptualizations reproduce hierarchies based on socio-economic conditions, age, disabilities, gender, ethnicity, and place of residence. Further, the article finds that the tensions between audiences in their capacity as citizens and consumers have been smoothed out and identifies the beginning of a nationalist turn in public service policy, as it moves from an emphasis on inclusion through acknowledging differences to the pursuit of a more assimilationist agenda and the creation of an essentialist Swedish identity.}, issn = {1354-8565} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_hysingerik_2025, title = {The Politics of Organizational Autonomy : Contrasting Bureaucratic Politics and Depoliticization}, author = {Hysing, Erik}, year = {2025}, pages = {63--78}, url = {2017538}, language = {eng}, publisher = {Edward Elgar Publishing}, abstract = {The autonomy of public organizations is a central aspect of academic and policy debates on how to come to grips with some of the world’s most pressing societal challenges. It not only raises key issues regarding governance but also draws attention to fundamental tensions between politics and administration in democratic societies. To understand how and why public organizations gain and maintain autonomy it is important to treat this as inherently political processes, shaped by struggles over how public authority is to be exercised in society. In this chapter two broad strands of research that analyze organizational autonomy from an explicitly political perspective are contrasted: Bureaucratic politics, understanding organizational autonomy as resulting from a tug-of-war within and between public organizations over power, resources, and critical tasks, and depoliticization, seeing organizational autonomy as a political response to handle problems generated by democratic politics. The chapter brings attention to important factors and mechanisms behind organizational autonomy, such as public organizations' exclusive expertise and constituency support as well as the role of structural politics, the need for credible policy commitments and political blame avoidance. The chapter concludes that the analytical lenses are complementary, helping to bring researchers' attention to different important mechanisms and political forces behind autonomy. The chapter ends by raising some critical questions about how to approach organizational autonomy, both as a research object and as a political phenomenon in democratic government. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_erteltsophiemarie_2025_1, title = {The polysemous nature of the German Verkehrswende-Exploring the role of floating signifiers in shaping mobility futures}, author = {Ertelt, Sophie-Marie and Hawxwell, Tom}, year = {2025}, journal = {Environmental Innovation and Societal Transitions}, volume = {55}, doi = {10.1016/j.eist.2025.100963}, url = {1938038}, language = {eng}, publisher = {Elsevier}, keywords = {mobility transition; transport sector; discourse network analysis; discursive framing struggles; floating signifier}, abstract = {The German transportation sector's negative contribution to climate change amongst broader social, environmental, and economic problems is applying evermore pressure to the prevailing automobility regime to bring about its transformation. However, the vision of this transition, referred to as the Verkehrswende or Mobilita<spacing diaeresis>tswende, is highly contested, with varying conceptions of different actors about the future of mobility in Germany. A discourse network analysis (DNA) is performed to examine the development of the related policy debate, identify key problem and solution framings and analyse the overall discourse evolution from 2018 to mid-2023. The findings highlight how recent exogenous events shape and reframe the discourse, inciting debates around viable mobility futures. Further, our analysis uncovers a novel discursive strategy termed repugnostic framing, through which incumbent actors aim to oppose the framings of other discursive agents, leading to increased lines of conflict and polarisation, thus possibly hindering effective policy implementation.}, issn = {2210-4224} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vivasana_2025, title = {The potential of bottom-up initiatives to produce a just transformation toward sustainable food consumption}, author = {Vivas, Ana and Chatzimpyros, Vasileios and Stergiadis, Christos and Türeli, Burcu and Holman, Andrei and Popusoi, Simona and Zorell, Carolin}, year = {2025}, journal = {The Journal of Agriculture, Food Systems, and Community Development}, volume = {15}, number = {1}, pages = {333--352}, doi = {10.5304/jafscd.2025.151.020}, url = {2035791}, language = {eng}, publisher = {New Leaf Associates, Inc.}, keywords = {bottom-up initiatives; gender+ intersectionality; food values; sustainable food consumption}, abstract = {In the past decade, grassroots communities and cit­izen collectives have emerged as a bottom-up response to take the lead in addressing social ine­qualities and environmental sustainability chal­lenges, including the promotion of environmentally sustainable food consumption. These bottom-up initiatives (BUIs) generate new transformative ideas while simultaneously creating resilient communities and a sense of solidarity and collective unity. Despite the growing interest in the potential trans­formative role of BUIs, there is scarcity of studies investigating their influence at the individual con­sumer level and exploring mechanisms of potential change. The present study investigated whether participation in BUIs—already being implemented in five countries—is associated with individual change in particular food values and consumption behavior. To do so, we conducted a mixed-methods real-life study focusing on inequalities through the adoption of a gender+ intersectional[1] understanding of vulnerability. The key finding is a significant BUI-related change in sustainable con­sumption (plant-based and seasonal food) and val­ues (animal welfare and health) associated with healthier and more sustainable food choices in a sample where the majority of people self-identified as being socially vulnerable on diverse and often multiple grounds. We also identify several potential vulnerability-related barriers for change and suggest potential mechanisms driving the changes based on the analyses of the interviews with the BUI’s organizers.[1] This term refers to a social vulnerability framework that considers how gender interacts with other aspects of a person’s identity and social categories such as class, sexuality, ethnicity etc. It emphasizes the complexity of identities and the cumulative effects of discrimination on multiple grounds.}, issn = {2152-0798} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_klingdaniel_2025, title = {The power of hybridization capture : llustrated using an expanded gene panel on 100 post mortem samples, focusing on sudden unexplained death}, author = {Kling, Daniel and Adolfsson, Emma and Gréen, Henrik and Green, Anna}, year = {2025}, journal = {Forensic Science International: Genetics}, volume = {74}, doi = {10.1016/j.fsigen.2024.103160}, url = {1908082}, language = {eng}, publisher = {Elsevier}, keywords = {forensic genetics; molecular autopsy; sudden unexplained death; targeted sequencing}, abstract = {Sudden unexpected death (SUD) is an unexpected event that in many cases are caused by diseases with an underlying genetic background. Forensic molecular autopsy is an approach that has gained wide-spread attention, in part explained by the rapid progress of DNA sequencing techniques. The approach leverages genetic data in combination with medical autopsy findings in post-mortem samples to explore a potential underlying genetic cause of death. Traditional forensic approaches to molecular autopsy focus on a small panel of genes, say <200 genes, with strong association to heart conditions whereas clinical genetics tend to capture entire exomes while subsequently selecting targeted panels bioinformatically. The drop in price and the increased throughput has promoted wider exome sequencing as a viable method to discover genetic variants. We explore a targeted gene panel consisting of 2422 genes, selected based on their broad association to sudden unexplained death. A hybridization capture approach from Twist Bioscience based on double stranded DNA probes was used to target exons of the included genes. We selected and sequenced a total of 98 post-mortem samples from historical forensic autopsy cases where the cause of death could not be unambiguously determined based on medical findings and that had a previous negative molecular autopsy. In the current study, we focus on the performance of the hybridization capture technology on a 2422 gene panel and explore metrics related to sequencing success using a mid-end NextSeq 550 as well as a MiSeq FGx platform. With the latter we demonstrate that our sequence data benefits from 2×300 bp sequencing increasing coverage, in particular, for difficult regions where shadow coverage, i.e. regions outside the probes, are utilized. The results further illustrate a highly uniform capture across the panel of genes (mean fold80=1.5), in turn minimizing excessive sequencing costs to reach sufficient coverage, i.e. 20X. We outline a stepwise procedure to select genes associated with SUD through virtual bioinformatical panels extracting tier of genes with increasing strength of association to SUD. We propose some prioritization strategies to filter variants with highest potential and show that the number of high priority genetic variant requiring manual inspections is few (0-3 for all tiers of genes) when all filters are applied.}, issn = {1872-4973} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_thunbergsara_2025_7, title = {The Process of Leaving a Domestic Violence Shelter for Mothers and Children}, author = {Thunberg, Sara and Arnell, Linda}, year = {2025}, journal = {Child & Family Social Work}, volume = {30}, number = {4}, pages = {614--622}, doi = {10.1111/cfs.13200}, url = {1858835}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {children; domestic violence shelter; mothers; moving; support}, abstract = {Domestic violence (DV) shelters provide a safe place for women and children; however, they are only intended to be a temporary solution until residents can find a safe place of their own. In Sweden, the social services are responsible for helping and supporting victims of DV to get away from the violence, which can include everything from practical help and housing to emotional support. The present article aims to investigate mothers' descriptions of leaving a DV shelter where they were staying with their children. Interviews with 13 mothers of children aged 0–6 years are analysed using thematic analysis. The results show that the process of leaving a DV shelter begins almost as soon as the mother and her children arrive, as it can take quite some time to find a new safe place and to mentally prepare for the move. Additionally, it takes a lot of effort to plan for life outside the shelter. This involves hardship for the mothers and children, meaning that they need support from both shelter staff and social services. Implications for social work practice and policy are discussed.}, issn = {1356-7500}, file = {https://oru.diva-portal.org/smash/get/diva2:1858835/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_schrderagneta_2025, title = {The Quality in Psychiatric Care-Outpatient Staff Instrument : Psychometric Evaluation and Staff Views on Quality of Care}, author = {Schröder, Agneta and Lundqvist, Lars-Olov}, year = {2025}, journal = {International Journal of Nursing Practice}, volume = {31}, number = {6}, doi = {10.1111/ijn.70082}, url = {2011866}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {quality in psychiatric care–outpatient staff (qpc‐ops); outpatient psychiatric care; psychometric properties; quality of care}, abstract = {AIM: The aim of the present study is to evaluate the psychometric properties and factor structure of the Quality in Psychiatric Care-Outpatient Staff (QPC-OPS) instrument and briefly describe the staff's views on the quality of care provided in general outpatient clinics as well as demographic and clinical factors associated with quality of care.METHOD: The study employed a cross-sectional design to conduct a psychometric evaluation and survey of staff perspectives. A sample of 143 permanently employed members of staff in multiprofessional teams at 15 outpatient clinics in Sweden completed the QPC-OPS, which consists of 30 items covering eight dimensions of quality of care. RESULTS: The QPC-OPS exhibited excellent psychometric properties, with a total alpha coefficient of 0.94, a test-retest reliability of 0.96 and a goodness-of-fit measure for the proposed model with a RMSEA value of 0.048. The staff's rating was generally high. Ratings were highest for Encounter and lowest for Accessibility. Staff who rated their own mental health as higher rated quality of care higher in most of the dimensions.CONCLUSION: The Swedish QPC-OPS showed excellent psychometric properties and is a useful, inexpensive and simple way to evaluate the quality of care in outpatient care and contributes to health care improvement in the field of psychiatric care. The low quality of the dimension of Accessibility indicates an important area for improvement.}, issn = {1322-7114} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_raskmikael_2025, title = {The Relationship Between Staff and Patient Interactions and Patients' Perceptions of Good Quality of Care in Psychiatric Outpatient Services : A Structural Equation Model}, author = {Rask, Mikael and Rytterström, Patrik and Sellin, Tabita and Lundqvist, Lars-Olov and Schröder, Agneta and Brunt, David}, year = {2025}, journal = {Scandinavian Journal of Caring Sciences}, volume = {39}, number = {2}, doi = {10.1111/scs.70043}, url = {1968192}, language = {eng}, publisher = {Blackwell Publishing}, keywords = {psychiatric outpatient care; quality of care; staff–patient interactions; structural equation model}, abstract = {BACKGROUND: The therapeutic relationship has been identified as essential for ensuring high-quality care in psychiatric outpatient services, as highlighted in several studies. This study focuses on the content of interactions between patients and staff in psychiatric outpatient care, as well as the quality of care provided, as perceived by the patients. AIM: The aim of this study is to explore the relationship between these interactions and aspects of the perceived quality of care from the perspective of patients in psychiatric outpatient services.METHODS: A sample of 706 patients from psychiatric outpatient clinics in Sweden completed the Verbal and Social Interaction Outpatient (VSI-OP) and the Quality in Psychiatric Care-Outpatient (QPC-OP) instruments. A structural equation model was conducted to explore these associations. The study was approved by the Regional Ethical Review Board in Uppsala, Sweden (Dnr. 2018/186).RESULTS: The model revealed that the staff showing an interest in the patients' feelings, experiences and behaviour influences the patients' perceived quality of participation through an intricate network of mediator variables, including the staff's ability to establish a relationship, a good encounter, support and a high level of information to the patients. High levels of Participation/Empowerment indicate a high level of quality of care in a psychiatric outpatient context.IMPLICATION FOR PRACTICE: The presented model provides an understanding of the associations between staff and patient interactions and perceived quality of care and sheds light on important aspects of quality of care from the perspective of the patients.}, issn = {0283-9318} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nordenskjldlina_2025, title = {The relative age effect on antidepressant use in children and adults}, author = {Nordenskjöld, Lina and Nordenskjöld, Axel}, year = {2025}, journal = {Journal of Affective Disorders}, volume = {378}, pages = {242--247}, doi = {10.1016/j.jad.2025.02.100}, url = {1941690}, language = {eng}, publisher = {Elsevier}, abstract = {BACKGROUND: Having young relative age in school is an identified risk factor for depression among schoolchildren, but it is unclear if this risk remains in adulthood. This study aimed to investigate the association between young relative age in school and antidepressant use across different age groups.METHOD: This population-based study used data from the Swedish Medical Birth Register and the Prescribed Drug Register combined with data from Statistics Sweden. The population of 3,575,510 subjects, (48.6 % female), was split into different age groups, with groups spanning from 0 to 7 years of age to 40-45 years of age. The odds ratios (OR) of antidepressant use in the first as compared to the fourth birth-quarters, was determined by logistic regression. RESULTS: Young relative age was positively associated with use of antidepressants with an OR of 1.05 (95 % confidence interval, 1.05-1.06) in the study population. This association was significant in all age groups that had started school and remained among adults.LIMITATIONS: Data on indication for antidepressant medication prescription was unavailable, some subjects might have had antidepressants for other disorders then anxiety and depression. Another limitation is that it is unclear when during schooling children were accelerated/deferred. Moreover, antidepressant medication is uncommon among small children.CONCLUSION: This study shows that young relative age within the school year increases the prevalence of antidepressant use in all investigated age-groups that had started school, long after the end of schooling.}, issn = {0165-0327} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_anderssonaxelg_2025_1, title = {The relative importance of fecal and urinary excretion of perfluorooctane sulfonic acid and perfluorooctanoic acid after high exposure : An observational study in Ronneby, Sweden}, author = {Andersson, Axel G. and Fletcher, Tony and Xu, Yiyi and Kärrman, Anna and Pineda, Daniela and Nilsson, Carina A. and Lindh, Christian H. and Jakobsson, Kristina and Li, Ying}, year = {2025}, journal = {Environmental Research}, volume = {285}, doi = {10.1016/j.envres.2025.122487}, url = {1990135}, language = {eng}, publisher = {Elsevier}, abstract = {Background: Many poly-and perfluoroalkyl substances (PFAS) are persistent and have long half-lives in the human body. However, there are limited data on the different routes of elimination. Most pharmacokinetic models assume that the urinary route dominates.Objectives: Our aim was to investigate the relative importance of fecal and urinary elimination for linear perfluorooctane sulfonic acid (L-PFOS), branched PFOS and perfluorooctanoic acid (PFOA), and to estimate volumes of distributions (Vds).Methods: Drinking water highly contaminated with PFAS from firefighting foam was distributed to many households in Ronneby, Sweden, from the 1980s to December 2013. In 2016, PFAS levels were measured in matched serum, feces and urine samples from 147 subjects. Daily urinary and fecal PFAS elimination was estimated through urinary creatinine elimination and dry fecal mass, respectively. Longitudinal serum PFAS elimination rates were used together with fecal and urinary elimination rates to estimate Vds.Results: In 2016, the median serum concentrations were 100 ng/mL for L-PFOS and 10 ng/mL for PFOA. L-PFOS was eliminated primarily through feces, with a median urinary elimination of 91 ng/day and median fecal elimination of 364 ng/day. The branched PFOS had, similarly, a primarily fecal elimination. In contrast, PFOA had a slightly higher urinary elimination, with median urinary elimination of 26 ng/day and fecal elimination of 15 ng/day. Median Vds were estimated at 93 mL/kg for PFOS and 74 mL/kg for PFOA.Conclusion: Fecal elimination was shown to be an important route for PFOS and PFOA elimination. Pharmacokinetic models need to take fecal elimination into consideration.}, issn = {0013-9351} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_berghandreas_2025_2, title = {The rise of law in education - exploring three drivers of juridification in the context of a changing welfare state}, author = {Bergh, Andreas and Murphy, Mark and Nylund, Mattias}, year = {2025}, journal = {Journal of education policy}, volume = {40}, number = {6}, pages = {1062--1080}, doi = {10.1080/02680939.2025.2517683}, url = {1985965}, language = {eng}, publisher = {Routledge}, keywords = {juridification; welfare; education; marketisation; accountability; human rights}, abstract = {This article takes as its starting point that governments in different countries increasingly tend to use legal means to solve societal problems and argues that this tendency reflects broader changes in the welfare state. While previous critical studies of education policy have contributed important knowledge on governance changes, the impact of the legal system has, however, until recently remained an outlier. By synthesising links between different theoretical and empirical contributions, the purpose of this article is to identify and explore key historical drivers for the development of juridification. The guiding research question is: Why juridification of education now - and how? To approach it, three interrelated and interwoven international trends are outlined: marketisation, accountability and human rights. The article contributes knowledge on how these three drivers have created contextual opportunities for juridification to develop, and invites further examination by the growing community of researchers dedicated to exploring juridification of and in education.}, issn = {0268-0939}, file = {https://oru.diva-portal.org/smash/get/diva2:1985965/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_olaussonulrika_2025, title = {"The road to the metaverse is not a straight one" : Social representations of virtual reality in the news media}, author = {Olausson, Ulrika and Engström, Annika}, year = {2025}, journal = {Convergence. The International Journal of Research into New Media Technologies}, volume = {31}, number = {4}, pages = {1288--1305}, doi = {10.1177/13548565251325530}, url = {1946360}, language = {eng}, publisher = {Sage Publications}, keywords = {critical media studies; digital media; discourse; metaverse; news journalism; social representation theory; tech industry power; tech journalism; vr; virtual reality}, abstract = {The metaverse is considered by some to be the next big thing in the global economy. Despite technological progress and high expectations, scholars agree that a broader metaverse platform does not yet exist. Instead, it has been suggested that the metaverse exists mainly as an imaginary or a representation in various discursive contexts. However, studies that examine such representations are few, and the present study aims to – through the lens of social representation theory – critically explore how VR technology and the metaverse are discursively represented in Swedish news media. The analysis identifies three underlying themata: (a) The inevitability of technology, (b) The commodification of experience, and (c) The world of male pioneers. It is concluded that the news media’s representation of VR and the metaverse contributes greatly to maintaining the structural status quo. For traditional journalism to fulfill its democratic mission, a pervasive update of medialogic is needed.}, issn = {1354-8565}, file = {https://oru.diva-portal.org/smash/get/diva2:1946360/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_schrderagneta_2025_1, title = {The Role of Burnout in Mental Health Professionals' Perception of Psychiatric Inpatient Care Quality}, author = {Schröder, Agneta and Lundqvist, Lars-Olov and Larsen Moen, Øyfrid and Skundberg-Kletthagen, Hege and Gonzalez, Marianne Thorsen}, year = {2025}, journal = {Issues in Mental Health Nursing}, pages = {1--8}, doi = {10.1080/01612840.2025.2582820}, url = {2018408}, language = {eng}, publisher = {Taylor & Francis}, abstract = {A review of the existing literature shows that although numerous factors influence the quality of care, only a few have been thoroughly investigated as potential mediators impacting mental health professionals' perceptions of quality in psychiatric inpatient care. This study aimed to explore how burnout mediates the relationship between individual characteristics, ward environment conditions and professionals' perceptions of the quality of psychiatric care patients receive. A total of 117 professionals from two Norwegian health trusts participated in the study. Data were collected through an online questionnaire comprising validated instruments measuring quality of care, job satisfaction, perceived stress and burnout while collecting background information on sociodemographic and work-related factors. The relationships between these variables were analyzed using univariate and multiple regression analyses. The results showed that professionals who were open for developing quality work, found their work stimulating, had sufficient time for tasks and were satisfied with their job reported lower levels of burnout. In turn, burnout was associated with lower perceived quality of participation and secure environment. Overall, professionals generally rated the quality of care as high. These findings provide insights for designing interventions to improve workplace conditions, reduce risk of burnout and enhance the quality in psychiatric inpatients settings.}, issn = {0161-2840} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_demirelkartheyaenejayaprakash_2025, title = {The Role of Caspase-1 and Caspase-4 in Modulating Gingival Epithelial Cell Responses to Aggregatibacter actinomycetemcomitans Infection}, author = {Demirel, Kartheyaene Jayaprakash and Neves Guimaraes, Alessandra and Demirel, Isak}, year = {2025}, journal = {Pathogens}, volume = {14}, number = {3}, doi = {10.3390/pathogens14030295}, url = {1948161}, language = {eng}, publisher = {MDPI}, keywords = {aggregatibacter actinomycetemcomitans; caspase-1; caspase-4; gingival epithelial cells; periodontitis}, abstract = {Periodontitis is a chronic inflammatory disease characterized by bacterial infection and immune dysregulation. Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is a key pathogen linked to disease progression. Caspase-1 and caspase-4 regulate inflammasome activation and cytokine release, yet their roles in gingival epithelial immunity remain unclear. The aim of this study was to elucidate the involvement of caspase-1 and caspase-4 in regulating the immune response to A. actinomycetemcomitans infection in gingival epithelial cells. Human gingival epithelial cells (Ca9-22) and caspase-1- and caspase-4-deficient cells were infected with A. actinomycetemcomitans for 24 h. Inflammatory mediator release was analyzed using Olink proteomics. Bacterial colonization and invasion were assessed using fluorescence-based assays and gentamicin protection assays. Caspase-1- and caspase-4-deficient cells showed significantly altered cytokine and chemokine profiles after infection with A. actinomycetemcomitans, showing reduced IL-17C and IL-18 release. We also found an increased release of TGF-α and LIF from caspase-4-deficient cells, along with elevated levels of the chemokines IL-8, CXCL9, and CXCL10. Additionally, both caspase-1- and caspase-4-deficient cells showed increased bacterial colonization and invasion, particularly in caspase-4-deficient cells. These findings suggest that caspase-1 and caspase-4 play distinct yet essential roles in gingival epithelial immunity, regulating cytokine release, barrier integrity, and defense against A. actinomycetemcomitans colonization.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_27, title = {THE ROLE OF EUROPEAN CASE LAW IN THE SYSTEM OF VALUE ADDED TAX}, author = {Kristoffersson, Eleonor and Kristoffersson, Magnus}, year = {2025}, pages = {71--83}, url = {2031863}, language = {eng}, publisher = {Wolters Kluwer}, keywords = {ai; value added tax} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_torsytim_2025, title = {The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers : A Systematic Review}, author = {Torsy, Tim and Tency, Inge and Beeckman, Dimitri and Isoherranen, Kirsi and Litchford, Mary and De Vylder, Flore}, year = {2025}, journal = {Wound Repair and Regeneration}, volume = {33}, number = {4}, doi = {10.1111/wrr.70077}, url = {1989826}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {arginine; glutamine; nutrition; pressure ulcer; wound healing}, abstract = {Pressure ulcers pose a significant health challenge, requiring effective management strategies. Nutrition, particularly arginine and glutamine, supports collagen synthesis and tissue repair. This review evaluates the role of enteral glutamine and arginine supplementation on wound healing outcomes, addressing gaps in previous research. A PRISMA-guided systematic search of five databases identified studies published between 2004 and 2024 on adults with pressure ulcers receiving these supplements. Outcomes assessed included healing time, wound size reduction, local infection, recurrence, and pain. A narrative synthesis was performed due to heterogeneity, with bias assessed via Cochrane RoB2 and JBI checklists. Fifteen studies involving 1085 participants were included. Findings indicated a trend toward improved healing with arginine or combined arginine/glutamine supplements, with relative wound size reductions of 18.6% to 98.2% over 2 to 20 weeks. However, inconsistencies were noted, with seven studies showing non-significant or unreported differences in wound size, and six studies with similar issues for healing time. Glutamine was examined only in combination with arginine, limiting insights into its isolated effects. None of the studies reported on recurrence or pain outcomes. While arginine shows potential for enhancing healing, evidence remains inconclusive. Future research should emphasise follow-up until complete wound closure and explore the independent effects of glutamine on wound healing outcomes.}, issn = {1067-1927} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_humbertannelaure_2025, title = {The role of intersectionality and context in measuring gender-based violence in universities and research performing organisations in Europe for the development of inclusive structural interventions}, author = {Humbert, Anne Laure and Strid, Sofia and Tanwar, Jagriti and Lipinsky, Anke and Schredl, Claudia}, year = {2025}, journal = {Violence against Women}, volume = {31}, number = {6-7}, pages = {1688--1711}, doi = {10.1177/10778012241231773}, url = {1829503}, language = {eng}, publisher = {Sage Publications}, keywords = {gender-based violence; intersectionality; surveys; research-performing organizations; theorizing quantitative measurement}, abstract = {The aim of the article is to discuss how thinking about gender-based violence intersectionally and in context can not only enrich our understanding but also lead to transformative change in organizations. The article argues that to better understand gender-based violence in universities and research institutions, analyses need to be intersectional and contextual. Such approaches go beyond binary understandings of gender and narrow legalistic definitions of gender-based violence. The article reflects on how to operationalize this to derive starting points for intersectional categories to consider and contextual factors to measure at micro-, meso-, and macro-levels. It concludes that a multilevel intersectional analysis leads to more nuanced knowledge on experiences of gender-based violence and is, therefore, better equipped to inform the development of measures to eradicate the problem in an inclusive way.}, issn = {1077-8012} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_deutschmannmats_2025_4, title = {The Role of Language-in-Education Policies in thePursuit of Inclusive Quality Education in Seychelles}, author = {Deutschmann, Mats and Zelime, Justin}, year = {2025}, journal = {Seychelles Research Journal (SRJ)}, volume = {7}, number = {special issue}, pages = {63--79}, doi = {10.5281/zenodo.16919341}, url = {1998122}, language = {eng}, publisher = {University of Seychelles}, keywords = {language policy; language supportive pedagogy; seychelles; seselwa; seychelles creole.}, abstract = {In this article, the authors present evidence and arguments that illustrate how language-in-education aspects are central to many of the challenges facing education in the Seychelles today. They argue that many of these challenges cannot be fully addressed without confronting the mismatch between the language of instruction and the language skills of the learners and teachers. By referring to evidence from more than a decade of their research on language-in-education policies in Seychelles, the authors show how ideologies and policies have counteracted the role of Kreol Seselwa in education leading to epistemic inequities in our system. The article discusses language-in-education policy issues at three different national levels in the system: at the formal policy level; in the field; and, finally, on a more general national level. It also looks ahead and presents concrete policy suggestions on how to address the challenges discussed. These suggestions are summarized in a proposed model for a more inclusive and equitable language-in-education policy that also considers the effects of language policies in Seychelles society as a whole.}, file = {https://oru.diva-portal.org/smash/get/diva2:1998122/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hodzabeganovicruhija_2025_1, title = {The role of leadership in enhancing non-technical skills in healthcare : a qualitative study in a Balkan context}, author = {Hodza-Beganovic, Ruhija and Berggren, Peter and Edelbring, Samuel}, year = {2025}, journal = {Human Resources for Health}, volume = {23}, number = {1}, doi = {10.1186/s12960-025-01022-2}, url = {2006417}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {balkans; healthcare; leadership; low- and middle-income countries; non-technical skills; teamwork}, abstract = {BACKGROUND: Leadership is widely recognized as essential for fostering collaborative healthcare teams and improving patient outcomes. However, there is limited research on how leadership supports the development of nonclinical skills in healthcare settings in many low- and middle-income countries, including those in the Balkan region. This study addresses that gap by examining how leadership roles and practices enhance non-technical skills (NTSs)-such as communication, teamwork, and role clarity-among healthcare workers in the Balkans while also considering sustainable development, organizational values, cultural influences, and social dynamics.METHODS: A qualitative approach was employed, drawing on data collected from three workshops conducted between 2018 and 2022 in university hospital clinics in Bosnia and Herzegovina, Kosovo, and Montenegro. Data sources included observations of group discussions, focus groups, and semi-structured interviews with healthcare leaders. Reflexive thematic analysis was used to identify patterns and develop key themes.RESULTS: Four key themes emerged regarding the role of leadership in the development of NTSs: (1) defining roles and responsibilities, (2) fostering communication and teamwork, (3) promoting readiness for change, and (4) developing leadership competencies. The participants noted that clear role definitions enhanced team coordination, inclusive communication reduced misunderstandings, supportive leadership eased resistance to change, and mentorship served as a valuable mechanism for leadership development.CONCLUSION: Leadership plays a key role in strengthening NTSs in Balkan healthcare contexts by promoting communication and teamwork within culturally and hierarchically complex environments. Role clarity, open dialogue, and shared accountability emerged as key factors for effective team performance and patient safety. These findings highlight the need for leadership development and the implementation of formal training initiatives-such as structured mentorship programs-to foster collaborative and resilient healthcare systems in low- and middle-income countries.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_schrootenmartiengs_2025, title = {The role of pain in adolescents' self-reported attentional control}, author = {Schrooten, Martien G. S. and Boersma, Katja}, year = {2025}, journal = {European Journal of Pain}, volume = {29}, number = {Suppl. 1}, url = {2039995}, language = {eng}, publisher = {WILEY}, abstract = {Background and aims: Pain and pain problems have been inversely associated with executive functioning and, more specifically, attentional control. Poor attentional control and negative beliefs about own level of attentional control relate to difficulties in emotion regulation and can impede everyday tasks, including school performance. Yet, individual differences in attentional control are not well-understood in the context of pain. The current analyses aimed to examine whether musculoskeletal pain predicts self-reported attentional control over time in a large sample of older adolescents. We also explored the role of psychological distress and rumination within this relationship.Methods: Data from the two last waves of a five-year longitudinal study (2014–2018) of Swedish high school students was used, with one year between waves. The analytic sample includes 2513 adolescents aged 17–18 years (50.8% girls) who participated during both waves. Questionnaire measures of musculoskeletal pain, attentional control (focusing and shifting), psychological distress, and rumination were used.Results: Greater levels of pain predicted lower attentional control (focusing) one year later. Anxiety, but not depressive symptoms or rumination, moderated the relationship between pain and attentional control. Depressive symptoms showed predictive value for future attentional control.Conclusions: The results highlight the importance of considering pain as a factor explaining individual differences in beliefs in own attentional control abilities, at least in older adolescents. These results are discussed in relation to recent views concerning the association between (chronic) pain and cognitive function.}, issn = {1090-3801} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_moreirahelena_2025, title = {The role of psychological flexibility in mindful parenting during the postpartum period : A longitudinal study on the mediating effect of maternal psychopathology}, author = {Moreira, Helena and Dias, Tatiana and Trindade, Inês A.}, year = {2025}, journal = {Journal of Contextual Behavioral Science}, volume = {38}, doi = {10.1016/j.jcbs.2025.100950}, url = {2007508}, language = {eng}, publisher = {Elsevier}, keywords = {psychological flexibility; postpartum anxiety; postpartum depression; mindful parenting}, abstract = {This study aimed to examine whether postpartum depression and anxiety mediated the relationship between psychological flexibility (PF)-measured through its three overarching dimensions: openness to experience, behavioral awareness, and engagement/valued action-and mindful parenting among postpartum women during the COVID-19 pandemic. Additionally, it investigated changes in postpartum anxiety, postpartum depression, and mindful parenting across two time points: before and during a lockdown period. A total of 363 mothers of children aged 0-5 months participated in an online longitudinal study. The first assessment (T1) was conducted in December 2020, a period marked by eased COVID-19 restrictions. The second assessment (T2) took place in March 2021, during the third wave of the pandemic, which coincided with a lockdown period. Mothers completed self-report measures of PF (CompACT-18), postpartum anxiety (PSAS-RSFC), postpartum depression (EPDS), and mindful parenting (IMP-I). Behavioral awareness showed a significant indirect effect on mindful parenting through postpartum depression, while openness to experience indirectly influenced mindful parenting through postpartum anxiety. However, the valued action dimension did not significantly predict mothers' mental health or mindful parenting outcomes. Postpartum depression, postpartum anxiety, and mindful parenting all increased over time. These findings suggest that interventions designed to enhance psychological flexibility-particularly by fostering awareness and openness-could be highly beneficial for new mothers, especially in uncertain or highstress situations such as the COVID-19 pandemic. Acceptance and Commitment Therapy, for example, may not only help postpartum mothers manage their mental health but also enhance their capacity for mindful parenting.}, issn = {2212-1447} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_velosobruna_2025, title = {The roles of self-compassion and social support on the maternal adjustment to a child's hip dysplasia}, author = {Veloso, Bruna and Palmeira, Lara and Carvalhais, Lénia and Marta-Simoes, Joana and Trindade, Inês A.}, year = {2025}, journal = {Journal of Health Psychology}, volume = {30}, number = {9}, pages = {2172--2182}, doi = {10.1177/13591053241295892}, url = {1918495}, language = {eng}, publisher = {Sage Publications}, keywords = {chronic illness in children; hip dysplasia; maternal adjustment; self-compassion; social support}, abstract = {Parenthood can be challenging when facing a child's chronic illness such as developmental dysplasia of the hip (DDH). Although social support is known as a protective factor for the caregiver's mental health, the role of self-compassion is less explored. This study, conducted in Portugal, explored whether self-compassion and social support mediate the relationship between mothers' psychological adjustment and perception of their child's illness. Ninety-four mothers of children with DDH completed questionnaires on illness perception, self-compassion, perceived social support, and psychological distress. Results suggested that self-compassion and social support mediated the relationship between mothers' overall negative perception of the children's illness and psychological distress. The final model accounted for 50% of the variance of depressive symptoms, 40% of anxiety, and 63% of perceived stress. This study highlights the potential value of encouraging mothers to seek social support when facing their child's DDH diagnosis. Promoting self-compassion may be important in clinical intervention.}, issn = {1359-1053} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_annerstedtclaes_2025, title = {The Second Women´s Olympic Games, Gothenburg, 1926}, author = {Annerstedt, Claes and Annerstedt, Marie and Barker-Ruchti, Natalie and Grahn, Karin}, year = {2025}, journal = {International Journal of the History of Sport}, doi = {10.1080/09523367.2025.2455602}, url = {1928009}, language = {eng}, publisher = {Taylor & Francis}, keywords = {1926 womens' games; olympic games; athletics; women; sweden; gender; sport organizations}, abstract = {This article examines the preparations, organization, and media coverage of the 2nd Women Olympic Games in Gothenburg, Sweden, in 1926. It explores the context of women's athletics in Sweden, which evolved amidst advancements in female liberation and efforts to promote women's participation in sports. However, the progress was hindered by a predominantly male-dominated sports organization with limited commitment to women's sports. The Games, orchestrated by influential men, were considered successful for Swedish women's athletics, but critical voices also raised concerns about whether athletics was suitable for women and if they had enough technical skills. As time passed, men took increasing control over women's athletics, diminishing female agency and influence. The study highlights the challenges and gender dynamics that shaped the course of women's sports in Sweden and reflects broader issues in the international sports landscape.}, issn = {0952-3367} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_bjrkvallanders_2025_7, title = {The Semiotics of the “Unfinished” : The Lost Highway and Other Signifiers of Unsustainable Development}, author = {Björkvall, Anders and Archer, Arlene}, year = {2025}, pages = {91--105}, doi = {10.4324/9781032719214-8}, url = {1948906}, language = {eng}, publisher = {Routledge}, keywords = {urban landscapes; sustainability; unsustainability; unfinished; sweden; south africa; semiotic landscapes studies; social semiotics; discourse}, abstract = {Urban landscapes are characterized by the presence of artefacts, buildings and other constructions in the process of “becoming.” This chapter looks at the ways in which (un)sustainability is produced through signifiers of the “unfinished” in the physical environment, drawing on examples from urban areas in Sweden and South Africa. Inspired by semiotic landscapes studies and utilizing a social semiotics methodology, the chapter locates sustainability at the intersection of material and semiotic design and social practice. It identifies the ways in which the unfinished can signify the end of a cycle, pointing to unsustainable destruction or indexing a circular movement of sustainable reuse and repurposing in urban spaces. It shows how signifiers of the unfinished point to poor planning (in the case of unfinished highways) or non-inclusive urban developments (in the case of building sites). The chapter first looks at unanticipated abandonment (in the form of freeways), then at ways of designing for change in landscape architecture, and finally the ways that social practices can “defrost” unfinished structures that have become frozen in time. Here non-anticipated practices can initiate cycles of change even in cases where the original design was unidirectional. Through this study, the authors thus expand on the concept of “sustainability” and emphasize the multimodal and contextualized nature of sustainability discourses.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hasselbladhhans_2025, title = {The shadow of war : The making of military institutional specificity}, author = {Hasselbladh, Hans}, year = {2025}, journal = {Dialogues in Sociology}, volume = {1}, number = {3}, pages = {263--272}, doi = {10.1177/29768667251349925}, url = {1991858}, language = {eng}, publisher = {Sage Publications}, keywords = {military organizations; military sociology; the shadow of war; transformative capacity; institutional specificity}, abstract = {The latent potential for every military actor, as well as for the resources controlled by military organizations, to be sacrificed by the state for political or existential purposes constitutes the central collective signifier of military existence. This potential is not merely vague fears and premonitions of a possible future but also a real mode of operation, most often distant, sometimes imminent, and on rare occasions, a reality. This looming possibility does not, however, imply simple or immediate consequences. It makes up an ever-present collective imagination – both shared and contested – and infused with collective emotions such as fear, pride, and a sense of duty. More formally, it could be described as a central imaginary signification, articulated in countless ways that ascribe meaning to the military as a social practice. The institutional specificity of the military is a deeply ingrained transformative capacity, not hierarchy, uniforms, or lethal weapons. There is nothing, literally, that is military per se. Military institutional specificity is thus a state of becoming – a potential in which anything within military organizations can be enrolled as part of a war machine. The perceived proximity to this war machine is ‘the shadow of war’: a simultaneously elusive and overwhelming source of meaning within all military organizations. The paper explores the becoming of military institutional specificity through the concepts of institutional transversality, affinity, and specificity.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nguyenanhhoang_2025_1, title = {The SIMPLIFY Protocol : A Monophasic Extraction System Suitable for Exposomics, Metabolomics, Lipidomics, and Proteomics Research}, author = {Nguyen, Anh Hoang and Castro Alves, Victor and Flores, Emilia Holmström and Barbosa, João Marcos G. and Kråkström, Matilda and Reinivuori, Päivikki and Kauko, Otto and Dickens, Alex and Oresic, Matej and Hyötyläinen, Tuulia}, year = {2025}, journal = {Analytical Chemistry}, volume = {97}, number = {47}, pages = {26175--26183}, doi = {10.1021/acs.analchem.5c05322}, url = {2018208}, language = {eng}, publisher = {American Chemical Society (ACS)}, abstract = {Advancing our understanding of human health and disease requires comprehensive analytical approaches capable of capturing the complex interplay between endogenous metabolism and environmental exposures. A major challenge in clinical research is the ability to capture multidimensional data, particularly a broad range of biochemical profiles, due to limitations of biological resources, time, and budget. In this study, we introduce the SIMPLIFY Protocol, a unified monophasic extraction method that enables the simultaneous extraction of chemical exogenous products and endogenous molecules. The method was evaluated against in-house extraction techniques, including protein precipitation with methanol (MeOH) and acetonitrile (ACN), and the Folch method using various sample types, particularly certified reference materials. We demonstrate that the SIMPLIFY Protocol not only performs comparably to our in-house methods but also offers enhanced versatility for additional applications such as derivatization and proteomics. The analyte abundances and reproducibility with this method strongly correlate with those from in-house-established techniques across diverse sample types. The method encompasses a broad spectrum of compounds, effectively profiling approximately 800 identified compounds, including polar compounds (e.g., amino acids), semipolar compounds (e.g., polyfluorinated compounds, bile acids, and lysophophatidylcholine), and nonpolar compounds (e.g., cholesteryl ester), with some limitations in extracting triacylglycerols. By maintaining simplified workflow and minimizing biological and resource consumption of multiple extractions, this method supports high-throughput exposomics/metabolomics and lipidomics studies. Furthermore, its streamlined design facilitates (semi)automation, making it highly suitable for large-scale clinical studies, where efficiency, cost-effectiveness, and sample availability are critical factors.}, issn = {0003-2700} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_leklara_2025_1, title = {The social geography of fear and acceptance : an interview study on attitudes toward LGBQ identities in residential aged care}, author = {Le, Klara}, year = {2025}, journal = {BMC Geriatrics}, volume = {25}, number = {1}, doi = {10.1186/s12877-025-06234-8}, url = {1988826}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {lgbtq; qualitative method; aged care; nursing home; sexuality; ageing; the social geography}, abstract = {Background: Older LGBQ (lesbian, gay, bisexual and queer/questioning) adults in residential aged care (RAC) navigate environments shaped by heteronormative norms, institutional structures, and the social dynamics of communal living. Unlike in private homes, RAC settings bring together individuals with diverse backgrounds, values, and attitudes, creating both opportunities for inclusion and risks of exclusion. This study examines how both LGBQ and non-LGBQ residents contribute to shaping the social and cultural conditions of RAC and how these dynamics influence older LGBQ adults' ability to express their sexual identity.Methods: This study employed a qualitative approach, conducting semi-structured interviews with 17 residents aged 78-95 years in Swedish RAC, including five individuals who identified within the LGBQ spectrum. A thematic reflexive analysis was conducted, drawing on Valentine's Social geography to examine how institutional norms, peer dynamics, and spatial conditions influence residents' opportunities to express their sexuality.Results: Findings revealed three main themes: Geography of RAC: Space and Norms, Sexual Identity and Belonging and Strategies for Safety and Visibility. The results suggests that heteronormativity and perceptions of ageing shape the attitudes within RAC environments, often rendering older LGBQ adults invisible as sexual beings. The presence and attitudes of other residents were found to play an important role in shaping the space, either reinforcing exclusion or fostering belonging. LGBQ residents described employing various strategies to navigate this terrain. While some participants experienced a sense of restriction, others found ways to assert their identity and challenge dominant norms.Conclusions: The study highlights that RAC is not only structured by formal policies but also co-created through everyday interactions among residents and staff. While previous research has emphasised the need for staff training and inclusive policies, these findings suggest that education alone may not be sufficient. This study argues that there may be value in establishing dedicated residential care facilities that are explicitly LGBTQ-friendly.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_norlingmartina_2025_1, title = {The social language environment - domain : ECEC teachers' self-reported ratings of strategies in teaching literacy}, author = {Norling, Martina}, year = {2025}, journal = {European Early Childhood Education Research Journal}, volume = {33}, number = {3}, pages = {466--482}, doi = {10.1080/1350293X.2024.2389191}, url = {1892707}, language = {eng}, publisher = {Routledge}, keywords = {early childhood literacy; ecec settings; teaching literacy; self-assessment}, abstract = {ECEC settings are children's first contact with early education, and ECEC teachers are expected to encourage and support children's early literacy development. This study aims to pilot test the self-assessment tool Social Language Environment - Domain, (SLE-D), in order to gain more knowledge about teachers' strategies when teaching literacy. Fifteen ECEC teachers used the tool as a support to focus on didactic strategies that provide conditions for children's early literacy development over 22 months. The data consists of (N = 299) self-reported and rated teaching activities across four time-points. Cronbach's alpha showed satisfactory internal consistency for the entire self-assessment tool, while each domain showed somewhat lower levels of consistency. Principal component analysis suggested a 5-factor solution, indicating subdimensions of the three dimensions. However, item mean values showed notable changes in ECEC teachers' ratings, which can be interpreted as teachers developing their strategies in literacy-related play activities by using the tool.}, issn = {1350-293X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sderqvistfredrik_2025, title = {The Solution-focused Intervention for Mental health (SIM) : description and feasibility testing of a positive psychology intervention in Swedish adolescents}, author = {Söderqvist, Fredrik and Uvhagen, Lena and Gustafsson, Johanna and Franklin, Cynthia}, year = {2025}, journal = {SSM - Mental Health}, volume = {8}, doi = {10.1016/j.ssmmh.2025.100493}, url = {1989263}, language = {eng}, publisher = {Elsevier}, keywords = {well-being; solution-focused; hedonism; eudemonism; coaching; adolescents; school interventions}, abstract = {A paucity of studies exists that report on the description and testing of school-based interventions set out to promote mental well-being among adolescents, particularly in a Swedish context. The aim of this paper is to describe a new strength-based intervention designed using the core elements of solution-focused brief therapy for coaching within a normative frame of mental well-being. The Solution-focused Intervention for Mental health (SIM) is a nine-week, classroom-based, group intervention that has been developed to be both feasible and effective in addressing the current public health challenge concerning adolescent mental health. The intervention is described in accordance with guidelines for group-based behaviour change interventions. The results of three subsequent studies are presented and they support the intervention's feasibility. These studies demonstrate improvements in student participation, session attendance and ratings, as well as in a mental well-being outcome. The first two studies show small effect sizes and the third shows a medium effect size, thereby further substantiating the efficacy of implementing SIM in upper secondary schools. The program is now ready to be evaluated in a forthcoming randomized controlled trial.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kurlandlisa_2025, title = {The Swedish National Emergency Registry (SVAR), a modern emergency care registry}, author = {Kurland, Lisa and Holmqvist, Lina and Ekelund, Ulf}, year = {2025}, journal = {European journal of emergency medicine}, volume = {32}, number = {3}, pages = {216--218}, doi = {10.1097/MEJ.0000000000001214}, url = {1956070}, language = {eng}, publisher = {Lippincott Williams & Wilkins}, issn = {0969-9546} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gerdtssonaxel_2025, title = {The Swedish national guidelines on penile cancer}, author = {Gerdtsson, Axel and Abedi, Eliya and Baseckas, Gediminas and Brorson, Håkan and Dorofte, Luiza and Fall, Sofia and Filipsson, Emelie and Forssell, Johan and Glombik, Dominik and Grelaud, Diane and Hellman, Fatou and Jakobsson, Anna-Karin and Kohestani, Kimia and Kristiansen, Sinja and Magnusson, Jenny and Nilsson, Kajsa and Nordlund, Per and Persson, Erik and Psarias, Theodoros and Skeppner, Elisabeth and Trägårdh, Elin and Ulvskog, Emma and Warnolf, Åsa and Öfverholm, Elisabeth and Kirrander, Peter}, year = {2025}, journal = {Scandinavian journal of urology}, volume = {60}, pages = {189--194}, doi = {10.2340/sju.v60.44463}, url = {2000035}, language = {eng}, publisher = {MJS Publishing}, keywords = {follow-up; guidelines; lymph node dissection; penile cancer; penile intraepithelial neoplasia}, abstract = {OBJECTIVE: The Swedish national guidelines on penile cancer were first published in 2013. The objective of the present study is to present the 2023 update of these guidelines and highlight the differences to the European Association of Urology (EAU) / American Association of Clinical Oncology (ASCO) guidelines on penile cancer.MATERIAL AND METHODS: A review of the literature and a comparison to the EAU / ASCO guideline on penile cancer was performed. Differences between the EAU / ASCO guidelines and the Swedish national guidelines are highlighted.  Results: The Swedish national guidelines on penile cancer emphasized the consultation of a national multidisciplinary treatment conference for all patients diagnosed with both primary and recurrent penile cancer or penile intraepithelial neoplasia (PeIN). Clinically lymph node negative patients diagnosed with >pT1G1 are offered dynamic sentinel node biopsy (DSNB). In the EAU / ASCO guidelines the DSNB is optional for T1aG2 patients. Penile cancer surgery is centralized to two hospitals. Perioperative chemotherapy is offered to patients with ≥N2. In the EAU / ASCO guidelines the use of perioperative chemotherapy for N2 patients is optional. A structured follow-up program is advocated to find recurrences at an early stage.CONCLUSIONS: The Swedish national guidelines on penile cancer have been updated and compared to the EAU / ASCO guidelines. The national multidisciplinary treatment conference, centralization of surgery, the use of perioperative chemotherapy and a structured follow-up are the cornerstones of the Swedish national guidelines on penile cancer.}, issn = {2168-1805} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alsarvedaniel_2025, title = {The Swedish sports confederation’s management and navigation through the COVID-19 pandemic}, author = {Alsarve, Daniel}, year = {2025}, journal = {Managing Sport and Leisure}, pages = {1--18}, doi = {10.1080/23750472.2025.2574322}, url = {2012183}, language = {eng}, publisher = {Routledge}, keywords = {sports; pandemic; infodemic management; institutional logics; crisis management}, abstract = {This study explores the Swedish Sports Confederation’s (RF) response to the COVID-19 pandemic, offering actionable insights into crisis management strategies. RF reshaped priorities and practices across the Swedish sports ecosystem by introducing a new institutional logic centred on infection control and emphasising the health-promotive role of sports. Using semi-structured interviews with 13 governing representatives, the research highlights RF’s initial decisions, adaptive strategies and the challenges of managing an unprecedented crisis. The pandemic caused significant disruptions, including activity declines and volunteer losses, yet also intensified conflicts and communication within the Swedish sports movement. RF demonstrated resilience and adaptability, employing infodemic management to balance public health mandates with organisational cohesion. This study underscores the importance of strategic internal and external negotiations in navigating complex crises, revealing how RF safeguarded societal interests while prioritising members’ well-being and setting a precedent for future crisis preparedness. }, issn = {2375-0472}, file = {https://oru.diva-portal.org/smash/get/diva2:2012183/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_johnstoneleanne_2025_7, title = {The transformative potential of control systems for sustainable innovations in industrial organisations}, author = {Johnstone, Leanne and Beusch, Peter}, year = {2025}, url = {1955312}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stresirijakobsson_2025_2, title = {The travel-hope framework : bridging hope, travel, and well-being}, author = {Störe, Siri Jakobsson and Friman, Margareta and Olsson, Lars E.}, year = {2025}, journal = {Transport reviews}, volume = {45}, number = {4}, pages = {537--556}, doi = {10.1080/01441647.2025.2487075}, url = {1954207}, language = {eng}, publisher = {Taylor & Francis}, keywords = {autonomy; hope; perceived accessibility; travel hope; travel behaviour; well-being}, abstract = {Hope is defined as the capability to pursue a desired goal by leveraging one's abilities and potential pathways to goal attainment. This study aims to (1) chart and integrate conceptualizations and operationalizations of hope in travel and well-being research, and (2) investigate the relationship between hope and travel behaviour, as well as its associations with well-being concepts relevant to travel behaviour research, as a base for developing a Travel-Hope Framework. A scoping review was conducted with the following inclusion criteria: (i) adult participants, (ii) validated hope scales, (iii) relevance to travel behaviour and well-being research, (iv) written in English, and (v) peer-reviewed. A systematic search identified 13 studies on hopes conceptualizations and measurement. While none explicitly explored its link to travel behaviour, hope was associated with cognitive, emotional, and social well-being components relevant to travel behaviour research. Building on these insights, we introduce the Travel-Hope Framework, which posits that hope - particularly in the form of travel autonomy and perceived accessibility, and experience and anticipation - is essential for behaviour change and well-being. By illuminating the role of hope in travel decision-making, this framework provides a novel perspective for travel research and policy. Understanding the dynamic interplay between hope, travel and well-being can inform targeted interventions to improve commuting experiences, foster equitable accessibility, and promote sustainable travel choices.}, issn = {0144-1647}, file = {https://oru.diva-portal.org/smash/get/diva2:1954207/FULLTEXT01.pdf} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_ramezaninina_2025, title = {The use of care home environments to meet culture-specific needs of culturally and linguistically diverse residents with dementia : An integrative review}, author = {Ramezani, Nina and Granberg, Sarah and Kihlgren, Annica and Baudin, Katarina and Lindner, Helen}, year = {2025}, url = {2007455}, language = {eng}, abstract = {Background: Increasing global migration creates new challenges for multicultural societies in providing equitable care. Culturally and linguistically diverse (CALD) people with dementia who move into care homes find themselves in an environment where health professionals do not speak their language and the access to cultural activities is limited. When designing care home environments for CALD dementia residents, culture is a key consideration. This integrative review aims to highlight what elements of care home environments are reported to meet culture-specific needs of CALD residents with dementia.Methods: The search strategy included search terms for care homes, various forms of dementia and the CALD population. A systematic search was carried out in six databases. Eligible articles were original peer-reviewed studies published in 2013-2024 that contained examples of how care home environments had been used. All screenings and extractions were carried out by two independent researchers.Results: The database search resulted in 4311 records. After the screening process, 27 articles were found to meet the eligibility criteria. The review findings are categorized according to components of the WHO’s International classification of functioning, disability and health (ICF). Results linked to the ICF component Activities and participation, stress the importance of communication in the resident’s preferred language, social and supportive relationships and culturally relevant activities, while the component Environmental factors highlight the significance of ethnic food and support from culturally competent care professionals and family members.Conclusions: This integrative review underlines the complexity of using environments to meet culture-specific needs of CALD residents with dementia. The findings highlight the importance of bilingual staff, culturally relevant activities and inclusive environments in enhancing communication, building interpersonal relationships and reducing frustration. This review gives suggestions on how care home environments may be adapted for CALD residents and encourages further research to find practical solutions for equitable care.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_chahedyasmine_2025, title = {The value of research activities “other than” publishing articles : reflections on an experimental workshop series}, author = {Chahed, Yasmine and Charnock, Robert and Du Rietz, Sabina and Lennon, Niels Joseph and Palermo, Tommaso and Parisi, Cristiana and Pflueger, Dane and Sundström, Andreas and Toh, Dorothy and Yu, Lichen}, year = {2025}, journal = {Accounting, Auditing & Accountability Journal}, volume = {38}, number = {1}, pages = {90--114}, doi = {10.1108/aaaj-05-2022-5818}, url = {1846357}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {interpretive accounting research; technologies of humility; early-career researchers; problematization; gap-spotting; reflexivity}, abstract = {Purpose: The purpose of this essay is to explore the opportunities and challenges that early-career researchers (ECRs) face when they seek to contribute to academic knowledge production through research activities “other than” those directly focused on making progress with their own, to-be-published, research papers in a context associated with the “publish or perish” (PoP) mentality.Design/methodology/approach: Drawing broadly on the notion of technologies of humility (Jasanoff, 2003), this reflective essay develops upon the experiences of the authors in organizing and participating in a series of nine workshops undertaken between June 2013 and April 2021, as well as the arduous process of writing this paper itself. Retrospective accounts, workshop materials, email exchanges and surveys of workshop participants provide the key data sources for the analysis presented in the paper.Findings: The paper shows how the organization of the workshops is intertwined with the building of a small community of ECRs and exploration of how to address the perceived limitations of a “gap-spotting” approach to developing research ideas and questions. The analysis foregrounds how the workshops provide a seemingly valuable research experience that is not without contradictions. Workshop participation reveals tensions between engagement in activities “other than” working on papers for publication and institutionalized pressures to produce publication outputs, between the (weak) perceived status of ECRs in the field and the aspiration to make a scholarly contribution, and between the desire to develop a personally satisfying intellectual journey and the pressure to respond to requirements that allow access to a wider community of scholars.Originality/value: Our analysis contributes to debates about the ways in which seemingly valuable outputs are produced in academia despite a pervasive “publish or perish” mentality. The analysis also shows how reflexive writing can help to better understand the opportunities and challenges of pursuing activities that might be considered “unproductive” because they are not directly related to to-be-published papers.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ahkingmalin_2025_1, title = {The variable nature of sex : An anthropologist shows why we should think beyond the binary [Resencion av The Biological Limits of the Binary]}, author = {Ah-King, Malin}, year = {2025}, journal = {Science}, volume = {388}, number = {6745}, pages = {368--368}, doi = {10.1126/science.adv3113}, url = {1954990}, language = {eng}, publisher = {American Association for the Advancement of Science (AAAS)}, abstract = {An anthropologist shows why we should think beyond the binary.}, issn = {0036-8075} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lassenkarstenlomholt_2025, title = {The Virtual Reality Tour : Immersive Preoperative Information for Elderly Patients}, author = {Lassen, Karsten Lomholt and Sjöberg, Carina and Augustinsson, Annelie and Joost, Maria and Christiansen, Nanna Wagner and Geisler, Anja and Jildenstål, Pether}, year = {2025}, journal = {Healthcare}, volume = {13}, number = {22}, doi = {10.3390/healthcare13222896}, url = {2017591}, language = {eng}, publisher = {MDPI}, keywords = {anesthesia; elderly patients; patient education; preoperative information; qualitative research; total knee arthroplasty; virtual reality}, abstract = {Background/Objectives: Older patients are more susceptible to the process of understanding and retrieving information. To provide adequate preoperative information, reduce their vulnerability and anxiety, and thereby facilitate pre-, intra-, and postoperative care, the adoption of new information technologies is essential. This study aimed to explore elderly patients' experiences and perceptions of a Virtual Reality (VR)-based preoperative informational tool designed for individuals scheduled to undergo TKA.Method: A qualitative content analysis was conducted from February to June 2025 based on 14 semi-structured post-discharge interviews. Participants were recruited as part of a randomized controlled trial.Results: One main theme and two categories describe patients' experiences of using VR information, which is perceived as a valuable supplement to standard preoperative information. The category "Using VR as an information tool" includes how patients experienced the immersive environment, how it affected them, and their views on using the VR glasses. The category "Apply the information provided" described how patients evaluated and applied the VR content in relation to their expectations and the actual surgical experience.Conclusions: Immersive virtual reality (VR) shows promise as a preoperative information tool, improving patients' understanding of the perioperative process and supporting engagement in their own care. Its effectiveness depends on reliable technical performance and adaptation to individual needs. VR should complement, not replace, communication with healthcare professionals. Further research is needed to identify optimal timing for VR delivery and its impact on preoperative anxiety and patient experience.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jakobssonhugo_2025_2, title = {The Volar Central Approach for Distal Radius Fracture : A Prospective Nerve Conduction Study of 38 Patients}, author = {Jakobsson, Hugo and Lundqvist, Eva and Nordkvist, Sara and Dahlbom, Kathe and Sagerfors, Marcus}, year = {2025}, journal = {Hand}, doi = {10.1177/15589447251366459}, url = {1995792}, language = {eng}, publisher = {Sage Publications}, keywords = {distal radius fracture; median nerve; nerve conduction study; volar central approach}, abstract = {BACKGROUND: In distal radius fracture (DRF) surgery with volar locking plates, the flexor carpi radialis approach is commonly used. However, the volar central approach (VCA), between the median nerve and the finger flexors, may improve visualization of the volar ulnar corner. A similar approach has been linked with a higher risk of iatrogenic median neuropathy. This study evaluated the risk of median neuropathy after operative treatment using the VCA.METHODS: Thirty-eight patients with Arbeitsgemeinschaft für Osteosynthesefragen (AO) type C DRF were assessed prospectively with sensory nerve conduction studies preoperatively and at 6 weeks, 3 months, and 12 months postoperatively. RESULTS: At 6 weeks, 30 of the 38 patients exhibited median neuropathy, decreasing to 12 of the 35 at 12 months. Subjective sensory deficit was reported by 12 of the 38 patients at 6 weeks and 8 of the 37 at 12 months. Patients with median neuropathy (MN) had significantly higher frequency of subjective sensory deficit of the median nerve 12 months postoperatively, but did not have significantly worse patient-reported outcome.CONCLUSIONS: Our results suggest that the VCA should be reserved for cases needing optimal exposure of the volar ulnar corner.}, issn = {1558-9447} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kvarnstrmmaria_2025, title = {The what and why of interprofessional collaboration according to first-year health professions students : a thematic analysis of written reflections}, author = {Kvarnström, Maria and Edelbring, Samuel and Lindh Falk, Annika}, year = {2025}, journal = {BMC Medical Education}, volume = {25}, number = {1}, doi = {10.1186/s12909-025-08375-1}, url = {2018409}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {health professions education; interprofessional competence; interprofessional education; interprofessional learning; medical education; reflective writing; thematic analysis}, abstract = {BACKGROUND: Interprofessional education (IPE) is highly recommended in health professions education, but there is still an ongoing discussion regarding when to introduce interprofessional educational activities. The development of students' professional and interprofessional competence during education is essential for fostering effective collaboration in future healthcare settings. This study explored how health professions students, in connection with their first IPE experience, reflect upon and express interprofessional competencies in relation to future collaborative work.METHODS: A qualitative design was employed using a reflexive thematic analysis based on first-year students' reflective writings, written during the first IPE module in a mandatory curriculum.RESULTS: Four themes were identified, representing crucial components for effective interprofessional collaboration. These themes are communication as a fundamental factor, professional knowledge as a common foundation, establishing trust within a workgroup, and, finally, navigating hierarchies in the evolving healthcare landscape. The students elaborated on these themes in relation to the context of collaborative work in professional teams, and emphasised the importance of the quality of care and patients' treatment outcomes.CONCLUSIONS: This study contributes to the discussion of the value of introducing IPE at an early stage of health professions education. The findings demonstrated that students can elaborate on interprofessional collaboration and patient safety in this early IPE intervention using brief reflective writing as part of an IPE module. With a clear focus on future professional work, the students identified interprofessional competencies as a part of their learning process.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_dobrebillstrmrebecca_2025, title = {The work-family reconciliation of self-employed musicians: A scoping review}, author = {Dobre Billström, Rebecca and Peltola, Henna-Riikka}, year = {2025}, url = {2020274}, language = {eng}, abstract = {This paper will investigate the work-life balance of self-employed musicians. Although there are many salaried jobs in different sectors of the music industry, self-employment is a typical form of work in all the fields of art and culture. In 2022, almost one-third of cultural workers across the EU were working as freelancers or entrepreneurs (Eurostat 2024). Despite the fact that many freelancers consider their work as fulfilling, the instability and uncertainty of work and income can cause a lot of stress that these professionals need to cope with, which puts them in a psychologically more vulnerable position compared to employed professionals. In addition, the music industry is permeated by gender inequalities, potentially affecting specifically women and non-binary freelancers’ work-life balance. Challenges caused by self-employment can affect musicians’ willingness or possibilities to have families, since dimensions of family life can create challenges for the wellbeing of parents regardless of their employment status. Having children brings along tensions for time use, family economy, and psychosocial resilience (Fawcett 1988; Nelson et al 2013; Collins & Glass 2018), which can further contribute to work-family conflicts. Furthermore, the music industry still seems to have a glass ceiling when it comes to gender and paid jobs, since in many countries, most professionals earning their living as musicians are men. It is likely that musicians struggle with more gendered difficulties and inequalities in work-family reconciliation compared to professionals in other fields. In this scoping review and paper, we will investigate the previous findings of how self-employed professionals of the music sector have balanced their work and family lives, and what kinds of challenges fre} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lanphamthi_2025, title = {The World Health Organization (WHO) Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP) reports continuously high levels of ceftriaxone resistance across Viet Nam, 2024}, author = {Lan, Pham Thi and Phan Nguyen, Thuy Thi and Anh, Vu Tuan and Golparian, Daniel and Thuy Van, Nguyen Thi and Maatouk, Ismael and Unemo, Magnus}, year = {2025}, journal = {The Lancet Regional Health: Western Pacific}, volume = {63}, doi = {10.1016/j.lanwpc.2025.101709}, url = {2009485}, language = {eng}, publisher = {The Lancet Publishing Group} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_santedda_2025, title = {Thinking hegemony otherwise – an educational critique of Mouffe’s agonism}, author = {Sant, Edda and Tryggvason, Ásgeir}, year = {2025}, journal = {Distinktion: Scandinavian Journal of Social Theory}, volume = {26}, number = {2}, pages = {229--244}, doi = {10.1080/1600910x.2024.2365758}, url = {1874530}, language = {eng}, publisher = {Taylor & Francis}, keywords = {democratic theory; hegemony; agonism; mouffe; biesta; education}, abstract = {The question ‘What is to be done?’ underpins Chantal Mouffe’s agonistic theory of democratic politics. Yet, despite this affirmative tone that distinguishes her from other radical theorists, her theory neglects the cultural work required for hegemony-building. This omission has resulted in operational difficulties when agonistic democracy is put into practice. This article shows how academics inspired by Mouffe unintentionally depend on theoretical resources from competing democratic theories. As a result of this, agonistic practices risk to reinforce neo-liberal regimes instead of developing counter-hegemonic alternatives. To meet this challenge, and to expand the scope of Mouffe’s agonism, we draw on educational theory to provide a more developed theorization of the cultural work required for hegemony-building. We propose that only by embracing different conceptualisations of education, we can activate cultural interventions that facilitate counter-hegemonic ventures.}, issn = {1600-910X}, file = {https://oru.diva-portal.org/smash/get/diva2:1874530/FULLTEXT01.pdf} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_orzikhyurii_2025_2, title = {Thinking of succession law in Modus Futuri Exacti : Challenges of recodification in the context of war and European integration}, author = {Orzikh, Yurii}, year = {2025}, pages = {471--489}, doi = {10.32837/11300.29933}, url = {1993573}, language = {ukr}, publisher = {Feniks}, keywords = {inheritance law; succession law; civil law; recodification; modus futuri exacti}, file = {https://oru.diva-portal.org/smash/get/diva2:1993573/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sagerforsmarcus_2025, title = {Thoracomelia in Poland Anomaly}, author = {Sagerfors, Marcus and Thordardóttir, Ásgerdur and Widehammar, Cathrine}, year = {2025}, journal = {Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca}, volume = {92}, number = {4}, pages = {237--240}, doi = {10.55095/achot2025/006}, url = {1993418}, language = {eng}, publisher = {Galen, spol. s r.o.}, keywords = {poland anomaly.; thoracomelia; ulnar aplasia}, abstract = {Poland Anomaly (PA) represents pectoral muscle hypoplasia in combination with various forms of hand anomalies. We report a case of PA with pectoral hypoplasia, an upper limb deficiency and an accessory extremity/digit on the ipsilateral thoracic wall (thoracomelia). To our knowledge, this is the first reported case of thoracomelia in PA.}, issn = {0001-5415} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_limeng_2025, title = {Threshold Signatures With Verifiably Timed Combining and Message-Dependent Tracing}, author = {Li, Meng and Ding, Hanni and Chen, Yifei and Qiao, Yan and Zhang, Zijian and Zhu, Liehuang and Conti, Mauro}, year = {2025}, journal = {IEEE Transactions on Information Forensics and Security}, volume = {20}, pages = {9477--9491}, doi = {10.1109/TIFS.2025.3607250}, url = {2004317}, language = {eng}, publisher = {IEEE}, keywords = {threshold signature; security; privacy; timed cryptography; commitment; key encapsulation}, abstract = {Threshold Signature (TS) is one of the fundamental cryptographic primitives adopted in many practical applications. Current Threshold, Accountable, and Private Signature (TAPS) schemes suffer from delayed combining, unverifiable combining, and message-independent tracing. More precisely, a malicious combiner may delay the combination of signature shares and replace some signature shares from honest signers with ones from colluding signers, and an unrestricted tracer can reveal signers' identities arbitrarily. In this work, we introduce a new scheme called TiMTAPS under a stronger security model. First, we sew homomorphic time-lock puzzles into the Schnorr signature, allowing puzzles to be combined and opened as needed. Second, we knit the Schnorr signature with homomorphic commitment for verifiable combining. Third, we infuse the combining phase with an identity-based key encapsulation mechanism for message-dependent tracing. Next, formalize the definitions and requirements for TiMTAPS. Then, we present a concrete construction and formally prove its privacy and security. We build a prototype of TiMTAPS based on Ethereum. Results from extensive experiments exhibit its practicability and efficiency, e.g., combining (tracking) 10 signature sets with a threshold value of 5 requires only 3.72 s (12.44 s) for the threshold signature.}, issn = {1556-6013} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_brancifortemartinaazzurra_2025, title = {Thromboprophylaxis timing and duration in bariatric surgery : impact on thromboembolism and bleeding}, author = {Branciforte, Martina Azzurra and Stenberg, Erik and Skogar, Martin Löfling}, year = {2025}, journal = {British Journal of Surgery}, volume = {112}, number = {Suppl. 11}, pages = {xi27--xi27}, doi = {10.1093/bjs/znaf149.096}, url = {1992652}, language = {eng}, publisher = {Oxford University Press}, abstract = {Introduction: Deep vein thrombosis (DVT) and pulmonary embolism (PE) are recognized complications following bariatric surgery, with incidences reported between 0.3% and 2.2%. While thromboprophylaxis is recommended, the optimal duration, dosage, and timing remain debated. This study evaluates the association between thromboprophylaxis regimens and postoperative DVT/PE and bleeding complications in a nationwide cohort.Method: A retrospective cohort study was conducted using data from the Scandinavian Obesity Surgery Registry (SOReg) from 2010 to 2023. Data included demographics, surgical details, thromboprophylaxis regimens, and six-week follow-up on DVT/PE and bleeding. Thromboprophylaxis duration (<7, 7–10, 11–14, >14 days) and initiation (preoperative vs. postoperative) were analysed using univariable and multivariable logistic regression, adjusting for risk factors.Result: Among 83,801 patients, 48,344 had thromboprophylaxis data, and 30,800 had recorded initiation timing. The overall incidence of DVT/PE was 0.09%, with no significant differences across treatment durations or initiation timing (p=0.33 and 0.12). Prior DVT/PE (OR 4.10, 95% CI 1.40–12.03, p=0.010) and intraoperative bleeding (OR 6.39, 95% CI 1.46–27.98, p=0.014) were associated with higher DVT/PE risk. Postoperative thromboprophylaxis initiation was linked to lower intraoperative bleeding risk (OR 0.66, 95% CI 0.47–0.93, p=0.046), while male sex, older age, cardiovascular disease, and antidepressant use were associated with increased postoperative bleeding risk.Discussion: Thromboprophylaxis duration and timing did not significantly affect DVT/PE incidence. However, postoperative initiation was associated with a lower risk of intraoperative bleeding. These findings may guide thromboprophylaxis strategies in bariatric surgery patients.}, issn = {0007-1323} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_petersonhelen_2025_2, title = {“Through Change and Through Storm, Better and Stronger” : Gendered Crisis Management Discourses in Swedish Academia}, author = {Peterson, Helen}, year = {2025}, pages = {21--45}, doi = {10.1007/978-3-031-98941-4_2}, url = {2019374}, language = {eng}, publisher = {Palgrave Macmillan}, abstract = {This chapter explores crisis management in Higher Education Institutions (HEIs) through a gender lens. It adopts Branicki’s (2020) distinction between rationalist approaches to crisis management characterised by authoritarian leadership and a masculine logic, and the alternative relationalist conceptualising of crisis management based on a feminist ethics of care. The chapter empirically draws on an analysis of academic crisis management discourses in blog posts published between 2020 and 2022 by eight Vice-Chancellors (VCs) (four women and four men) at Swedish HEIs. The analysis demonstrates that discourses that support a rationalist approach to crisis management dominated among the blogs during the COVID-19 crisis, often reproducing traditional masculine management and leadership ideals. The results, however, also identify expressions of the relationalist approach, communicated by female VCs to a higher degree than the male VCs. These alternative discourses raised otherwise silenced questions, recognised marginalised groups, and provided encouragement and support in times of crisis.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_schreitertim_2025_2, title = {THÖR-MAGNI : A large-scale indoor motion capture recording of human movement and robot interaction}, author = {Schreiter, Tim and Almeida, Tiago Rodrigues de and Zhu, Yufei and Gutiérrez Maestro, Eduardo and Morillo-Mendez, Lucas and Rudenko, Andrey and Palmieri, Luigi and Kucner, Tomasz P and Magnusson, Martin and Lilienthal, Achim J.}, year = {2025}, journal = {The international journal of robotics research}, volume = {44}, number = {4}, doi = {10.1177/02783649241274794}, url = {1908218}, language = {eng}, publisher = {Sage Publications}, keywords = {dataset for human motion; human trajectory prediction; human–robot collaboration; social hri; human-aware motion planning}, abstract = {We present a new large dataset of indoor human and robot navigation and interaction, called THÖR-MAGNI, that is designed to facilitate research on social human navigation: for example, modeling and predicting human motion, analyzing goal-oriented interactions between humans and robots, and investigating visual attention in a social interaction context. THÖR-MAGNI was created to fill a gap in available datasets for human motion analysis and HRI. This gap is characterized by a lack of comprehensive inclusion of exogenous factors and essential target agent cues, which hinders the development of robust models capable of capturing the relationship between contextual cues and human behavior in different scenarios. Unlike existing datasets, THÖR-MAGNI includes a broader set of contextual features and offers multiple scenario variations to facilitate factor isolation. The dataset includes many social human–human and human–robot interaction scenarios, rich context annotations, and multi-modal data, such as walking trajectories, gaze-tracking data, and lidar and camera streams recorded from a mobile robot. We also provide a set of tools for visualization and processing of the recorded data. THÖR-MAGNI is, to the best of our knowledge, unique in the amount and diversity of sensor data collected in a contextualized and socially dynamic environment, capturing natural human–robot interactions.}, issn = {0278-3649} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_almeidatiago_2025_1, title = {THÖR-MAGNI Act : Actions for Human Motion Modeling in Robot-Shared Industrial Spaces}, author = {Almeida, Tiago and Schreiter, Tim and Rudenko, Andrey and Palmieri, Luigi and Stork, Johannes A. and Lilienthal, Achim J.}, year = {2025}, pages = {1083--1087}, doi = {10.1109/HRI61500.2025.10973897}, url = {1941542}, language = {eng}, publisher = {IEEE}, keywords = {human motion dataset; human motion modeling; human activity prediction}, abstract = {Accurate human activity and trajectory prediction are crucial for ensuring safe and reliable human-robot interactions in dynamic environments, such as industrial settings, with mobile robots. Datasets with fine-grained action labels for moving people in industrial environments with mobile robots are scarce, as most existing datasets focus on social navigation in public spaces. This paper introduces the THÖR-MAGNI Act dataset, a substantial extension of the THÖR-MAGNI dataset, which captures participant movements alongside robots in diverse semantic and spatial contexts. THÖR-MAGNI Act provides 8.3 hours of manually labeled participant actions derived from egocentric videos recorded via eye-tracking glasses. These actions, aligned with the provided THÖR-MAGNI motion cues, follow a long-tailed distribution with diversified acceleration, velocity, and navigation distance profiles. We demonstrate the utility of THÖR-MAGNI Act for two tasks: action-conditioned trajectory prediction and joint action and trajectory prediction. We propose two efficient transformer-based models that outperform the baselines to address these tasks. These results underscore the potential of THÖR-MAGNI Act to develop predictive models for enhanced human-robot interaction in complex environments.}, file = {https://oru.diva-portal.org/smash/get/diva2:1941542/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jeppssonanders_2025, title = {Ticagrelor and Aspirin or Aspirin Alone after Coronary Surgery for Acute Coronary Syndrome}, author = {Jeppsson, Anders and James, Stefan and Moller, Christian H. and Malm, Carl Johan and Dalén, Magnus and Vanky, Farkas and Modrau, Ivy Susanne and Andersen, Karl and Anttila, Vesa and Atroshchenko, Gennady V. and Barbu, Mikael and Dreifaldt, Mats and El-Akkawi, Ali Imad and Friberg, Örjan and Gudbjartsson, Tomas and Gunn, Jarmo and Haaverstad, Rune and Halonen, Jari and Hansson, Emma C. and Holm, Jonas and Husso, Annastiina and Juvonen, Tatu and Jakobsen, Øyvind and Jideus, Lena and Johannesson, Emilia and Jonsson Holmdahl, Anna and Jonsson, Kristjan and Kolseth, Solveig Moss and Krasniqi, Lytfi and Mäkelä, Tuomas and Mennander, Ari and Mohagen Krogstad, Lars-Erik and Rafiq, Sulman and Raivio, Peter and Riber, Lars and Tahir, Aminah and Thorsen, Carl and Tønnessen, Theis and Wahba, Alexander and Zindovic, Igor and Pivodic, Aldina and Nielsen, Susanne J. and Erlinge, David and Alfredsson, Joakim and Sartipy, Ulrik}, year = {2025}, journal = {New England Journal of Medicine}, volume = {393}, number = {23}, pages = {2313--2323}, doi = {10.1056/NEJMoa2508026}, url = {1994584}, language = {eng}, publisher = {Massachusetts Medical Society}, abstract = {BACKGROUND: Patients benefit from antiplatelet therapy after coronary-artery bypass grafting (CABG) for an acute coronary syndrome. Whether the addition of ticagrelor to aspirin, as compared with aspirin alone, further reduces the risk of adverse cardiovascular outcomes is unclear.METHODS: In this open-label, registry-based, clinical trial conducted at 22 Nordic cardiothoracic surgery centers, we randomly assigned patients in a 1:1 ratio to receive either ticagrelor plus aspirin or aspirin alone for 1 year after CABG for an acute coronary syndrome. The primary outcome was a composite of death, myocardial infarction, stroke, or repeat revascularization, evaluated at 1 year. A key secondary outcome was net adverse clinical events, defined as a primary-outcome event or major bleeding.RESULTS: A total of 2201 patients were randomly assigned to receive ticagrelor plus aspirin (1104 patients) or aspirin alone (1097 patients). The mean age of the patients was 66 years, and 14.4% were women. A primary-outcome event occurred in 53 patients (4.8%) in the ticagrelor-plus-aspirin group and 50 (4.6%) in the aspirin-alone group (hazard ratio, 1.06; 95% confidence interval [CI], 0.72 to 1.56; P = 0.77). Net adverse clinical events occurred in 9.1% of patients in the ticagrelor-plus-aspirin group and 6.4% in the aspirin-alone group (hazard ratio, 1.45; 95% CI, 1.07 to 1.97). Major bleeding occurred in 4.9% of patients in the ticagrelor-plus-aspirin group and 2.0% in the aspirin-alone group (hazard ratio, 2.50; 95% CI, 1.52 to 4.11).CONCLUSIONS: Among patients who underwent CABG for an acute coronary syndrome, ticagrelor plus aspirin did not result in a lower incidence of death, myocardial infarction, stroke, or repeat coronary revascularization than aspirin alone at 1 year. (TACSI ClinicalTrials.gov number, NCT03560310; EudraCT number, 2017-001499-43; EU Clinical Trials number, 2023-508551-40-00.).}, issn = {0028-4793} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bogdanovaelena_2025, title = {Time, Care, and Sustainability : Temporal Conflicts and Housing Renovation}, author = {Bogdanova, Elena and Soneryd, Linda}, year = {2025}, journal = {Housing, Theory and Society}, volume = {42}, number = {2}, pages = {171--186}, doi = {10.1080/14036096.2024.2371316}, url = {1886010}, language = {eng}, publisher = {Taylor & Francis}, keywords = {housing; renovation; temporalities; care; sustainability; participation}, abstract = {This paper contributes to the wider discourse on sustainability and housing by showing how the dynamics of temporality and care plays out in processes of renovation. We explore five empirical cases of renovation of rental housing estates on the outskirts of Gothenburg, Sweden. Our study draws on the analysis of documents, observations, and qualitative interviews with key actors. We consider renovation a caring practice, both in the practical sense of "caring for" and in the emotional and ethical sense of "caring about". We argue that conflicts between stakeholders in renovation processes are better understood through attending to the ways in which notions of care are intertwined with the temporal organization of peoples' lives and organizational processes. We conclude that unawareness or negligence towards the various temporalities involved in renovation processes provide obstacles for collective processes of caring and raising sustainability concerns in renovation processes.}, issn = {1403-6096} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lovaneluclia_2025_1, title = {Tissue microarray validation in cervical carcinoma studies : A methodological approach}, author = {Lovane, Lucília and Carrilho, Carla and Karlsson, Christina}, year = {2025}, journal = {Histology and Histopathology}, volume = {40}, number = {3}, pages = {317--325}, doi = {10.14670/HH-18-796}, url = {1889509}, language = {eng}, publisher = {University of Murcia, Murcia, Spain}, keywords = {cervical cancer; tissue microarray; immunohistochemistry; heterogeneity; validation}, abstract = {Tissue microarrays (TMAs) are a cost-effective tool to study biomarkers in clinical research. Cervical cancer (CC) is one of the most prevalent in women worldwide, with the highest prevalence in low-middle-income countries due to a lack of organized screening. CC is associated with persistent high-risk human papillomavirus infection. Several biomarkers have been studied for diagnostic, therapeutic, and prognostic purposes. We aimed to evaluate and validate the effectiveness of TMA in CC compared to whole slide images (WSs). We selected and anonymized twenty cases of CC. P16, cytokeratin 5 (CK5), cytokeratin 7 (CK7), programmed death-ligand 1 (PD-L1), and CD8 expression were immunohistochemically investigated. All WS were scanned and 10 representative virtual TMA cores with 0.6 mm diameter per sample were selected. Ten random combinations of 1-5 cylinders per case were assessed for each biomarker. The agreement of scoring between TMA and WS was evaluated by kappa statistics. We found that three cores of 0.6 mm on TMA can accurately represent WS in our setting. The Kappa value between TMA and WS varied from 1 for p16 to 0.61 for PD-L1. Our study presents an approach to address TMA sampling that could be generalized to TMA-based research, regardless of the tissue and biomarkers of interest.}, issn = {0213-3911} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_28, title = {Tjänster inom regelefterlevnad och riskhantering är mervärdesskattepliktiga}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031768}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 30 december 2024 kom Högsta förvaltningsdomstolens dom i mål nr 3825-24. Högsta förvaltningsdomstolen kom fram till att tjänster inom regelefterlevnad och riskhantering är mervärdesskattepliktiga. Professor Eleonor Kristoffersson kommenterar domen.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tynikristiina_2025_2, title = {To find oneself in existential motion through unfamiliar terrain : a phenomenological Reflective Lifeworld Research study of becoming a parent to a child expressing a transgender or gender diverse identity in Sweden}, author = {Tyni, Kristiina and Wurm, Matilda and Bratt, Anna Sofia}, year = {2025}, journal = {International Journal of Transgenderism}, doi = {10.1080/26895269.2025.2540423}, url = {1992464}, language = {eng}, publisher = {Taylor & Francis}, keywords = {children and youth; gender identity; parent; qualitative; transgender}, abstract = {Background: Parental support is a crucial protective factor for the well-being of transgender and gender diverse (TGD) children and youth. Yet, parents often undergo complex processes before reaching an affirming stance.Aim: This is the first study to explore the experiences of Swedish parents to TGD children.Methods: The study explored Swedish parents' lived experiences of the phenomenon "becoming a parent to a child expressing a TGD identity" using a Reflective Lifeworld Research (RLR) approach to capture the essence of the phenomenon. Twenty-eight cisgender parents from nineteen families across Sweden participated in in-depth lifeworld interviews.Results: The essence of the phenomenon was to find oneself in existential motion through unfamiliar terrain, further detailed by three constituents: (1) The unsettling of gendered familiarity, (2) Seeking certainty in uncertainty, and (3) Self-reflection and shifting relationships.Discussion: The phenomenon was shaped by cisnormative assumptions, triggering emotional dissonance and conflicting emotions, yet also of hope and recognition. The results highlighted the emotional labor required to support the children while managing internal tensions, as well as the potential for personal gender reflection, understanding, and expression of gender. These findings expand previous international research by emphasizing relational and existential dimensions and by adding experiences from a Swedish context.Conclusion: The study underscores the need for enhanced knowledge about gender diversity, clearer guidelines, and accessible and reflective support systems for parents, fostering space also for emotional processing, relational negotiation, and identity work in the light of cisnormativity. Such systems are vital for promoting the health and resilience of both TGD children, youth, and their families.}, issn = {2689-5269} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hlmanchristoffer_2025_3, title = {To read in Finnish? The use of Finnish in eighteenth-century popular education}, author = {Åhlman, Christoffer}, year = {2025}, url = {1960598}, language = {eng}, keywords = {early modern; popular education; minority language; political steering}, abstract = {In 1682, Charles XI of Sweden issued a royal decree concerning the Finnish-speaking population in the provinces of Gästrikland and Hälsingland. According to the decree, the Finnish-speaking population had failed to learn Swedish. Thus, their knowledge of the Catechism had suffered. The solution was that only Swedish was to be used in popular education. Does the decree reflect how popular education was organised? Which strategies were used in popular education to address the lack of adequate knowledge? Traces in the historical records tell us that Finnish was used in popular education despite efforts to favour Swedish. By focusing on Färila, Alfta, and Järvsö parish in Hälsingland c. 1680–1730, this paper studies which strategies were used when teaching Finnish-speaking parish members, who were behind them and how they were implemented.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_ulversofia_2025, title = {Too Beautiful : Caring Masculinities in Swedish Gangster Rap Culture}, author = {Ulver, Sofia and Vallström, Niklas}, year = {2025}, url = {1978701}, language = {eng}, abstract = {This paper explores the overlooked affective beauty through ‘care’ (Elliott 2016) in a visibly violent consumer culture, the one of Swedish gangster rap. 'Ethics of care' promotes well-being within social relations, but its impact varies contextually. We highlight its beauty and power even under toxic conditions, where excess becomes lethal.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bergwallandreas_2025, title = {Topic-specific characteristics of proof-related reasoning}, author = {Bergwall, Andreas}, year = {2025}, journal = {International Journal of Mathematical Education in Science and Technology}, volume = {56}, number = {4}, pages = {583--604}, doi = {10.1080/0020739X.2023.2255190}, url = {1595092}, language = {eng}, publisher = {Taylor & Francis}, keywords = {combinatorics; integrals; logarithms; mathematics textbook; proof-related reasoning; upper secondary school}, abstract = {Students’ difficulties with proofs are well documented. To remedy this, it is often recommended that reasoning and proving be focused on in all grades and content areas of school mathematics. However, proofs continue to have a marginal place in many classrooms, or are only given explicit attention in courses in Euclidean geometry. Geometry is also the most common topic for educational research on reasoning and proving. This paper compares what four other topics in secondary school mathematics – logarithms, primitive functions, definite integrals, and combinatorics – can offer in terms of opportunities to learn proof. The types and natures of reasoning in expository sections and students’ tasks in 11 Swedish and Finnish textbooks are analysed in search of similarities and differences between these topics. The results are accounted for with special focus on opportunities for reasoning about general cases. Finally, the findings are discussed in relation to mathematical aspects of the four analysed topics.}, issn = {0020-739X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_reiserdaniel_2025_3, title = {Total Wrist Arthroplasty With a New Design, 20 Cases With 8-Year Follow-Up}, author = {Reiser, Daniel and Fischer, Per and Pettersson, Kurt and Wretenberg, Per and Sagerfors, Marcus}, year = {2025}, journal = {Journal of Hand Surgery-American Volume}, volume = {50}, number = {3}, pages = {377e1--377e8}, doi = {10.1016/j.jhsa.2023.08.004}, url = {1798010}, language = {eng}, publisher = {Elsevier}, keywords = {total wrist arthroplasty; arthritis; osteoarthritis}, abstract = {PURPOSE: Total wrist arthroplasty (TWA) is an established motion-preserving alternative to arthrodesis in the treatment of wrist arthritis, but post-TWA complications requiring additional surgery remain an issue. A new TWA design has been proposed. The purpose of this study was to report the outcome of a cohort study of 20 patients who underwent surgery using the new TWA design.METHODS: Patients were assessed before surgery and at 1, 2, and 8 years after surgery for visual analog scale (VAS) pain scores, wrist range of motion, hand grip strength, and patient-reported outcome measures (PROMs). Radiographic examination was conducted for evidence of prosthetic loosening. Reasons for revision were analyzed.RESULTS: In total, 24 reoperations were performed, including 12 revisions in 6 patients. Patient-reported outcome measures improved significantly at the 2-year follow-up compared with preoperative values. Hand grip strength, wrist extension, and VAS pain scores improved significantly at the 2-year follow-up. No radiographic loosening of the components was observed, but backing out of the carpal screws was noted in 16 of the 20 cases.CONCLUSIONS: The new TWA resulted in improved VAS pain scores, PROMs, wrist extension, and hand grip strength. The high frequency of reoperation is a concern, and modification of the implant is needed.TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.}, issn = {0363-5023} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_reiserdaniel_2025_4, title = {Total Wrist Arthroplasty With Tantalum Coating : 20 Cases With a Mean Follow-Up of Six Years}, author = {Reiser, Daniel and Sagerfors, Marcus and Pettersson, Kurt and Wretenberg, Per and Fischer, Per}, year = {2025}, journal = {Journal of Hand Surgery-American Volume}, volume = {50}, number = {11}, pages = {1334--1344}, doi = {10.1016/j.jhsa.2025.07.040}, url = {1999631}, language = {eng}, publisher = {Elsevier}, keywords = {arthritis; osteoarthritis; total wrist arthroplasty}, abstract = {PURPOSE: Despite improvements in total wrist arthroplasty (TWA) designs, periprosthetic osteolysis, and implant loosening are challenging issues. A new TWA implant design with a tantalum coating has been proposed to address these issues. This study reports the results of a pilot study of 20 cases operated on with the new TWA design.METHODS: Of the 20 cases, 14 were primary TWAs and 6 were revision TWAs. Patients were assessed using visual analog scale pain scores, wrist range of motion, hand grip strength, and patient-reported outcome measures (PROMs) before surgery and 1, 2, and no later than 8 years after surgery. Radiographic examination was performed to assess any loosening of the TWA.RESULTS: Of the 20 patients, 19, including 12 men and 7 women, came for postoperative follow-up at a mean of 6.5 years (5-8 years). Two reoperations were performed in two patients in the primary TWA group, compared with seven reoperations in six patients in the revision TWA group. Three of the reoperations were revision surgeries with conversion to radiocarpal arthrodesis, one in the primary TWA group and two in the revision TWA group. All three radiocarpal arthrodeses healed radiographically, but one of the patients underwent implant removal because of prominent hardware. Another patient in the revision TWA group had loosening of the articular head at the snap-fit mechanism and was offered revision surgery but declined further operative treatment. The radiographic examinations did not indicate implant loosening at the last follow-up. Range of motion, PROMs, and visual analog scale pain scores all improved at final follow-up.CONCLUSIONS: The new TWA design gave improved PROMs, and the frequency of implant loosening was low. The number of revisions remains a concern, but most followed the revision TWA.Type of study/level of evidence: Therapeutic IV.}, issn = {0363-5023} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_goncalvesricardo_2025_3, title = {Touch as a pedagogical action for male teachers and children in ECEC}, author = {Goncalves, Ricardo}, year = {2025}, url = {1993735}, language = {eng}, keywords = {male teachers; children; pedagogical action; touch; ecec.}, abstract = {This study aims to understand different types of physical touch in the interplay between male teachers and children through a pedagogical perspective. Previous research shows touch has been subject to surveillance due to a discourse on children’s protection and their rights to bodily integrity (Piper et al., 2013). Men, as a minority group working in Swedish ECEC, even in other countries, express that they are extra careful when involved in touch situations with children (Brody et al., 2020). There is, though, a lack of observational studies focusing on touch interactions between men and children in ECEC. The study draws upon pragmatism by examining touch as a "transaction" between teachers, children, and their environment (Dewey & Bentley, 1949/1991). Fieldwork with participant observation has been conducted in three preschool groups in Sweden, with 45 children and three male teachers. Field notes and video recordings were used for data collection, which was analysed using a qualitative abductive approach. Ethical principles such as anonymity, confidentiality, and informed and negotiated consent, were followed continuously during the research process. The findings show five types of touch as pedagogical actions: focus-oriented action, guiding action, assisting action, affectionate action, and playful action. Touch can be short or long-term and is used in different forms, such as patching, holding, and other light-touch forms. These findings suggest that touch, as a pedagogical action, can support children’s learning and caring relations with their teachers during several situations. Touch, understood as a pedagogical action, also contributes to strengthening male teachers’ professional practice in ECEC.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bostrmmagnus_2025_1, title = {Toward a sharing society? A theoretical model of the social conditions for sharing}, author = {Boström, Magnus and Lidskog, Rolf}, year = {2025}, journal = {Sustainability: Science, Practice, & Policy}, volume = {21}, number = {1}, doi = {10.1080/15487733.2025.2514882}, url = {1979157}, language = {eng}, publisher = {Taylor & Francis}, keywords = {consumerism; nonprofit sharing; sharing economy; sharing practices; transformation}, abstract = {This article theorizes the role of sharing in the broader transformation of society toward sustainability. In a context where overconsumption prevails, adopting strategies that move away from reliance on private possessions and ownership and in the direction of more collective approaches, such as the sharing of goods, resources, and services, is crucial. We undertake an integrative literature review specifically predicated on a theoretical understanding of the social conditions for nonprofit sharing. It builds on a conceptual model of the social that is based on five facets: inner life, social relationships and interactions, socio-material arrangements, social stratification, and institutions. We stress that while digitalization and smart use of technology may facilitate the mainstreaming of some sharing practices, not least through market-based initiatives, there is a risk that these forms of commercialized sharing will only complement continued and increased consumption. Therefore, the decisive and urgent question is to foster a nonprofit sharing economy that also counteracts consumerism and overconsumption, and a prerequisite for this objective is to develop and support more noncommercial forms of sharing. Prioritizing the five facets of the social provides insights into the various opportunities, barriers, and challenges that organizers of nonprofit sharing face. These insights can be further tested in policy and practice and explored in future research.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_qandeelmais_2025_8, title = {Towards a Legal Understanding of Repair in Cybersecurity}, author = {Qandeel, Mais}, year = {2025}, url = {1993423}, language = {eng}, abstract = {Cybersecurity has lately been a concern to international legal scholarship, especially when cyberoperations and cyber warfare are involved. It is well-established in international law that a cyber-attack is connected to the notions of ‘violence’ and ‘physical harm’ and refers to either the means of warfare or their effects in an operation causing violent effects. The violent effects also constitute an attack even if the means used to cause those effects are not violent. States have recognised that cyberoperations against critical infrastructure and critical information infrastructure supporting essential services to the public cause serious and devastating security, economic, social and humanitarian consequences – both in times of peace and conflicts. Thus, deploying the law of state responsibility is most appropriate to determine when and how States are responsible and must make full reparation for the injury caused by their wrongful act. This contribution to the panel Cybersecurity and the Politics of Repair: Infrastructures, Maintenance, and Materialities will discuss the peculiarities of repair in relation to damages done to cyber and physical infrastructures under international rules and norms, including restitution, compensation, satisfaction and guarantees of non-repetition.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssonfredrik_2025_4, title = {Towards a Speech Act-Based Model to Enable Future Quality Improvements of Information Security Policies Using Large Language Models}, author = {Karlsson, Fredrik and Gao, Shang and Krogstie, John and Aro-Sati, Leila}, year = {2025}, volume = {562}, pages = {349--364}, doi = {10.1007/978-3-032-04375-7_22}, url = {2005318}, language = {eng}, publisher = {Springer}, keywords = {information security policy; speech act; large language model}, abstract = {Employees compliance with information security policies (ISPs) depends on communicating clear and comprehensible content. However, existing research has shown that many ISPs are of poor communicative quality. Large language models (LLMs) could enhance ISPs if finetuned on high-quality data, but to do such fine-tuning requires a conceptual model for classifying the data and evaluating the resulting text. Therefore, as a step in this direction, the aim of this paper is to develop a conceptual model of ISPs using speech act theory as a theoretical lens. We use conceptual modelling and document analysis to develop the model and use selected parts from the SEQUAL framework to evaluate the model. Analysing 600 ISP statements from ten British National Health Service ISPs, we present a class diagram containing 19 classes, six of which address ISP statement quality as speech acts. The SEQUAL evaluation points to potential areas for improving the model’s semantic, empirical, physical and deontic qualities before using it to fine-tune LLMs to improve ISP content.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_abadzhievandrey_2025, title = {Towards High Circularity : Reconfiguring Firm-level Strategy}, author = {Abadzhiev, Andrey and Carlborg, Per and Sukhov, Alexandre}, year = {2025}, journal = {British Journal of Management}, doi = {10.1111/1467-8551.70019}, url = {2006812}, language = {eng}, publisher = {John Wiley & Sons}, abstract = {The transition to a circular economy (CE) is increasingly recognized as a strategic priority for companies striving for more sustainable business operations. Previous CE research adopted different firm-level strategy perspectives with varying degrees of alignment to the management literature. However, scholars have struggled to combine these perspectives in ways that effectively guide firms' transitions towards a CE. This study aims to unpack the CE strategy concept and examine it as a system of interconnected perspectives. First, drawing on the existing literature, we propose a nuanced framework that distinguishes between CE design, innovation and organizational strategies. Second, using empirical data from the Swedish wood construction industry, we analyse CE strategies as distinct configurations by applying configuration theory and a configurational approach. Through fuzzy-set qualitative comparative analysis (fsQCA), we identify four firm-level configurations that demonstrate different design efforts to achieve high levels of circularity. These configurations are enabled by specific innovation strategies and organizational capabilities within companies. Our findings offer valuable contributions to CE research and provide actionable insights for managerial practices.}, issn = {1045-3172} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_bhattmehul_2025, title = {Towards Responsible AI Foundations for Neurocognitive Analytics of Vision}, author = {Bhatt, Mehul}, year = {2025}, url = {2024227}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rostamielham_2025_1, title = {Towards software for tailoring information security policies to organisations’ different target groups}, author = {Rostami, Elham and Karlsson, Fredrik and Kolkowska, Ella and Gao, Shang}, year = {2025}, journal = {Computers & Security}, volume = {159}, doi = {10.1016/j.cose.2025.104687}, url = {2007036}, language = {eng}, publisher = {Elsevier}, keywords = {tailored information security policy; policy component; software for tailoring policy; design science research}, abstract = {Designing accessible and relevant information security policies (ISPs) that support employees is crucial for improving organisations' information security. When employees are required to deal with cumbersome ISPs, there is a risk of reduced motivation towards information security, and employees' not following the rules in ISPs has been reported as a persistent issue. Existing research has suggested adopting a tailored approach to ISPs in order to enhance their relevance to employees. Tailoring is difficult and time consuming and information security managers lack information security management systems software (ISMSS) that can assist with this tailoring task. In this paper, we develop a design theory for ISMSS to support information security managers in tailoring ISPs to different employees. To achieve this, we employ design science research, drawing on prior studies concerning the tailoring of systems development methods. We evaluate the design theory through an expository instantiation, POLCO, and with information security managers, demonstrating both proof-of-concept and proof-of-value.}, issn = {0167-4048} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_martnezbotapatricia_2025, title = {Towards standardization and a concerted vision for platelet proteomics research : communication from the SSC of the ISTH}, author = {Martínez-Botía, Patricia and Tassi Yunga, Samuel and Szklanna, Paulina and Babur, Ozgun and Emili, Andrew and Wilmarth, Phillip A. and Heemskerk, Johan W. M. and Maguire, Patricia B. and Iding, Aaron F. J. and Ramström, Sofia and García, Ángel and Aslan, Joseph E. and Gutiérrez, Laura}, year = {2025}, journal = {Journal of Thrombosis and Haemostasis}, volume = {23}, number = {5}, pages = {1704--1716}, doi = {10.1016/j.jtha.2025.02.002}, url = {1937957}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {biomarkers; blood platelets; mass spectrometry; proteomics; hemostasis}, abstract = {Over the past 3 decades, omics technologies have revolutionized our understanding of platelet molecular content and organization, enabling the systematic analyses of platelet physiology. Among these approaches, proteomics has been especially significant in discovering as well as validating molecular mechanisms of platelet function in health and disease. However, several conceptual and practical challenges continue to limit the full utility of platelet proteomics tools and data. Methodological and analytical inconsistencies remain a key concern, with biological and technical variables exerting substantial influence on study outcomes and interpretation. These issues are compounded by the rapid pace of proteomics tool development and dataset collection, outstripping efforts to standardize best practices and ensure consensus, as platelet proteomics consolidates itself as a tool for research even outside the thrombosis and hemostasis field. In this communication from the International Society on Thrombosis and Haemostasis Scientific and Standardization Committee, we highlight recent advances in platelet proteomics studies, and we identify where collective efforts can strengthen experimental design, execution, and analysis. As a practical recommendation, we encourage platelet biologists to recognize current discrepancies and advance efforts to standardize and customize methods and reporting practices, including blood collection, platelet isolation, data acquisition, and data interpretation. By aligning protocols and ensuring detailed reporting, the field can more effectively integrate proteomics findings and accelerate our understanding of platelet biology.}, issn = {1538-7933} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lundqvistcarolina_2025, title = {Toxic leadership in high-performance sports and its consequences for mental health and performance : a scoping review}, author = {Lundqvist, Carolina and Camps, Jeroen and Vertommen, Tine and Barker-Ruchti, Natalie and Kolbeinsson, Örn}, year = {2025}, journal = {International Review of Sport and Exercise Psychology}, doi = {10.1080/1750984X.2025.2457038}, url = {1929304}, language = {eng}, publisher = {Routledge}, keywords = {abuse; dark triad; elite sport; destructive leadership; toxic culture}, abstract = {This scoping review aimed to identify the current state of knowledge on toxic leadership in high-performance sports and its consequences for mental health and performance at individual, interpersonal, and organizational levels. Abstract screening (n = 768) and full-text review (n = 83) resulted in the inclusion of 26 studies, predominantly conducted in North America and Europe. Studies used inconsistent definitions, theoretical frameworks, and methodological approaches to study darker or toxic leadership. Several antecedents and maintaining factors to toxic leadership were identified, such as individual leader characteristics, a performance-oriented culture, status/power structures, and a lack of reporting processes or consequences within organizations. The empirical literature provided initial support for the negative consequences of toxic leadership on athletes' mental health, injuries, and motivation to remain in high-performance sports. Few studies have investigated the consequences of toxic leadership on sports organizations, staff or coaches. We conclude that research on toxic leadership in high-performance sports is in its early stages, with an underdeveloped understanding of how problematic leadership can be detected, prevented, and addressed to minimize its impact in sports. Researchers, governing bodies, and sports organizations must intensify their efforts to comprehend the emergence and persistence of toxic leadership within high-performance sports environments.}, issn = {1750-984X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_parodisioannis_2025_13, title = {Trajectories of disease evolution upon treatment initiation in systemic lupus erythematosus : results from four clinical trials of belimumab}, author = {Parodis, Ioannis and Lindblom, Julius and Tsoi, Alexander and Palazzo, Leonardo and Sporre, Karin Blomkvist and Enman, Yvonne and Nikolopoulos, Dionysis and Beretta, Lorenzo}, year = {2025}, journal = {Rheumatology}, volume = {64}, number = {5}, pages = {2697--2705}, doi = {10.1093/rheumatology/keae575}, url = {1906646}, language = {eng}, publisher = {Oxford University Press}, keywords = {belimumab; disease activity; disease trajectories; patient-reported outcomes; randomised clinical trial; systemic lupus erythematosus}, abstract = {OBJECTIVE: Upon commencement of therapy for active disease, patients with systemic lupus erythematosus (SLE) show varying evolution regarding disease activity measures and patient-reported outcomes (PROs). Our objective was to identify disease evolution trajectories to gain a deeper understanding of SLE progression, ultimately improving future trial design.METHODS: Patients with ≥2 visits and available data on SLEDAI-2K, BILAG, PGA, FACIT-F, and glucocorticoid use were included in a post-hoc analysis of four randomised controlled trials of belimumab (BLISS-52, BLISS-76, BLISS-SC, EMBRACE). Growth mixture modelling identified latent classes.RESULTS: Among 2868 patients analysed, baseline median disease duration was 4.5 (IQR: 1.5-9.7) years and mean (± standard deviation) SDI 0.7 (±2.0), SLEDAI-2K 10.2 (±3.6), BILAG 17.0 (±7.8), PGA 1.5 (±0.5), FACIT-F 30.6 (±11.9), and prednisone dose 11.0 (±8.9) mg/day. In the initial model, glucocorticoid use and dose yielded high standard errors, indicating a weak link with the latent process. A refined model considered only clinical measures and FACIT-F, corrected for intervention and SDI; no other covariates improved the fit. Four classes best described disease evolution: highly active, responders; highly active, non-responders; moderately active, responders; moderately active, non-responders. LLDAS and DORIS remission attainment associated with latent classes.CONCLUSION: By linking disease activity measures with PROs, we identified four distinct trajectories describing SLE evolution following the initiation of therapy. This classification could be valuable for personalising treatment and guiding biological studies aimed at distinguishing patients with varying anticipated treatment responses, as no single clinical variable alone can predict disease progression.}, issn = {1462-0324} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_golovchanovanadezhda_2025_2, title = {TRAJECTORIES OF SCHOOL ABSENTEEISM : LONGITUDINAL ASSOCIATIONS WITH PAIN AND STRESS IN CHILDHOOD AND WITH SICK LEAVE AND DISABILITY PENSION IN ADULTHOOD}, author = {Golovchanova, Nadezhda and Bergbom, Sofia and Boersma, Katja}, year = {2025}, url = {1954910}, language = {eng} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_saeidzadehzara_2025_1, title = {Trans* citizenship : A feminist socio-legal analysis of theories and practices}, author = {Saeidzadeh, Zara}, year = {2025}, pages = {161--180}, doi = {10.1007/978-3-031-75423-4_8}, url = {1932220}, language = {eng}, publisher = {Springer Nature}, keywords = {trans citizenship; feminist politics}, abstract = {Feminist approaches to citizenship have for a long time problematized the traditional view of male, white, heterosexual, and able-bodied citizenship. Nonetheless, many feminist theories on citizenship are based on the gender binary system and the idea of universal rights for all, which tend to erase differences and structural inequalities (Monro and Warren, Sexualities 7(3):345–362, 2004; Monro, The limits of gendered citizenship: contexts and complexities, Routledge, 2010; Monro and Van der Ros, Crit Soc Policy 38(1):57–78, 2018; Kuhar et al., Crit Soc Policy 38(1):99–120, 2018). In this chapter, I discuss how feminist politics address trans* people’s citizenship using the concept of trans* citizenship developed by Surya Monro (Crit Soc Policy 23(4):433–452, 2003), Monro (The limits of gendered citizenship: contexts and complexities, Routledge, 2010), while engaging with Nancy Fraser’s understanding of recognition (Fraser, New Left Rev 1(3):107–120, 2000; Fraser, Crit Inq 34(3):393–422, 2008). Thus, I focus on the politics of recognition that emphasises the status and needs of citizens in achieving social justice. Through examining the use of some theoretical concepts in feminist politics, I discuss how the limits of identity-based politics of recognition in feminist theories and practices have amounted to social injustices and denial of trans* people’s needs, affecting their citizenship. Thus, I maintain that trans* citizenship needs feminist socio-legal researchers, practitioners, and policy makers’ attention to social status and needs of trans* people with respect to people’s diversity of knowledge and experiences. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_razasadaf_2025, title = {Trans RCED-UNet3+ : a hybrid CNN-transformer model for precise lung nodule segmentation}, author = {Raza, Sadaf and Zia, Razia and Usmani, Irfan Ahmed and Almujally, Nouf Abdullah and Alasbali, Nada and Hanif, Muhammad}, year = {2025}, journal = {Frontiers in Oncology}, volume = {15}, doi = {10.3389/fonc.2025.1654466}, url = {2011144}, language = {eng}, publisher = {Frontiers Media S.A.}, keywords = {lidc-idri; rced-unet 3+; hybrid loss function; lung nodule; transformer bottleneck}, abstract = {INTRODUCTION: Precisely segmenting lung nodules in CT scans is essential for diagnosing lung cancer, though it is challenging due to the small size and intricate shapes of these nodules.METHODS: This study presents Trans RCED-UNet3+, an enhanced version of the RCED-UNet3+ framework designed to address these challenges. The model features a transformer-based bottleneck that captures global context and long-range dependencies, along with residual connections that facilitate efficient feature flow and prevent gradient loss. To improve boundary accuracy, we employ a hybrid loss function that combines Dice loss with Binary Cross-Entropy, enhancing the clarity of nodule edges.RESULTS: Evaluation on the LIDC-IDRI dataset demonstrates a notable advancement, as Trans RCED-UNet3+ achieves a Dice score of 0.990, exceeding the original model's score of 0.984.DISCUSSION: These findings underscore the value of merging convolutional and transformer architectures, delivering a robust approach for precise segmentation in medical imaging. This model enhances the detection of subtle and irregular structures, enabling more accurate lung cancer diagnoses in clinical environments.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_saeidzadehzara_2025_2, title = {Trans* Women's Experiences of Epistemic Misrecognition in Swedish Law and Society}, author = {Saeidzadeh, Zara}, year = {2025}, journal = {Social Politics: International Studies in Gender, State and Society}, volume = {32}, number = {4}, pages = {1207--1231}, doi = {10.1093/sp/jxaf019}, url = {1957321}, language = {eng}, publisher = {Oxford University Press}, keywords = {trans*; women; sweden; policies and practices; violence; social justice; status recognition}, abstract = {This article aims to highlight social injustice experienced by trans* women in Sweden, drawing on diverse experiences encompassing (in)direct, ignorant, interpersonal harms as well as institutionalized and structural discrimination. The concept of epistemic misrecognition in this article draws on Fricker's notion of epistemic injustice and Fraser's idea of status misrecognition, emphasizing misrecognition as the root cause of epistemic injustices. Using twenty-four semi-structured interviews with trans* women and trans* activists in Sweden, as well as relevant laws and policies, I argue that the lack of status recognition in society at individual, institutional, and structural levels results in trans* women experiencing various forms of testimonial and hermeneutical injustices.}, issn = {1072-4745} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_saeidzadehzara_2025_3, title = {Trans women’s status in contemporary Iran : Misrecognition and the cultural politics of aberu}, author = {Saeidzadeh, Zara}, year = {2025}, journal = {Sexualities}, volume = {28}, number = {5-6}, pages = {1852--1876}, doi = {10.1177/13634607231200552}, url = {1796557}, language = {eng}, publisher = {Sage Publications}, keywords = {trans women; status misrecognition; violence; iran}, abstract = {In this paper, I explore the socio-legal status of trans women in contemporary Iran especially as it relates to Gender Affirmation Surgery. More specifically, I try to understand how trans women embody gender by investigating gender practices and relations in family, law, and medicine. Based on my fieldwork in Iran, the findings suggest that aberu – a phenomenon specific to Iranian culture – plays a big role in shaping trans women’s lives. By bringing together feminist philosopher Nancy Fraser’s work on the politics of recognition and sociologist Raewyn Connell’s understanding of social embodiment, I discuss how the status of trans women is pervasively misrecognised and how they are denied economic participation and democratic representation in Iranian society. Adopting the method of thematic analysis, I argue that the social pressure associated with aberu, and the lack of legal protection have made trans women simultaneously invisible and yet also subject to violence. Finally, I discuss how trans women go through the process of gender embodiment by problematising misrecognition, redefining femininity, and reclaiming womanhood through everyday life challenges.}, issn = {1363-4607}, file = {https://oru.diva-portal.org/smash/get/diva2:1796557/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wongsy_2025, title = {Trans-continental analysis of determinants of response to COVID-19 vaccination in 2268 patients with Inflammatory Bowel Disease}, author = {Wong, S. Y. and Moran, H. R. and Rajauria, P. and Giselbrecht, E. and Wellens, J. and Vermiere, S. and Watanabe, K. and Kamikozuru, K. and Halfvarson, Jonas and Bergemalm, Daniel and Silverberg, M. S. and Ng, S. C. and Mak, J. W. Y. and Ahuja, V and Virmani, S. and Kedia, S. and Lindsay, J. O. and Abreu, M. T. and Allez, M. and Rubin, D. T. and Dutta, U. and Sinha, S. K. and Sharma, V and Samanta, J. and Shah, J. and Singh, A. K. and Kaur, H. and Kaplan, G. and Thompson, C. and Colombel, J. F. and Satsangi, J.}, year = {2025}, journal = {Journal of Crohn's & Colitis}, volume = {19}, number = {Suppl. 1}, pages = {I1369--I1371}, doi = {10.1093/ecco-jcc/jjae190.0875}, url = {1938202}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background: Little is known about the relative efficacy of available COVID-19 vaccine types around the world in immune-compromised patients with inflammatory bowel disease (IBD).1,2 We aimed to compare antibody responses to SARS-CoV-2 in patients with IBD who had received mRNA, vector, and inactivated virus vaccines and the impact of medications thereof among multinational sites.Methods: Serum samples taken after 1st, 2nd, and 3rd doses of COVID-19 vaccines from patients with IBD seen at 13 sites across Europe, Asia, and North America were prospectively collected between January 2021 and November 2022. We measured anti-Spike (S) and anti-nucleocapsid (N) antibody levels. To identify determinants of serological responses to vaccination, both univariate and multivariate analyses were conducted.Results: There were a total of 2,268 patients, including 1,279 Crohn’s disease (CD) and 868 ulcerative colitis (UC) (Table 1). 1552 patients had an mRNA vaccine, 590 an adenovirus vaccine, and 98 an inactivated virus vaccine. At 14-84 days, 85-168 days, and 169+ days after completing a full vaccination series, the proportion of patients who were positive for anti-S antibodies were 98% (n=922/939), 96% (n=700/731), and 98% (n=677/692) for mRNA, 95% (n=378/396), 89% (n=55/62), and 97% (n=33/34) for adenovirus, and 72% (n=21/29), 84% (n=31/37), and 95% (n=55/58) for inactivated virus vaccine, respectively.On univariate analysis, rates of serological response were highest in those who received mRNA vaccines at all six time periods (Figure 1a). Adenovirus vaccine response rates closely resembled the rate of seropositivity in mRNA vaccinated patients. In contrast, inactivated vaccines had a significantly lower percent of patients reaching seropositivity until 169 days or more after the second vaccine dose (p<0.001). Anti-TNF mono-therapy and immunomodulator monotherapy were associated with the ability to obtain maximum antibody titres. However, this difference is ablated after the 3rd dose (Figure 1c).Univariate analysis also implicated geographical site, male sex, and a diagnosis of ulcerative colitis as determinants of serological responses.On multi-variable analysis, vaccine type (p < 0.001 at every time point analysed) and the use of immunomodulators (p <0.001 at time points 1 and 3) were confirmed as independent determinants of vaccine responsiveness across the study populations.Conclusion: Our data suggests that while there is variability between geographical centers, the response rates are high worldwide, and the key determinants of serological response to vaccines are the use of immunosuppressive agents and vaccine class.3 These data are important considerations for better pandemic preparedness in the IBD community worldwide.References:(1) Wong SY, Wellens J, Helmus D, et al. Geography Influences Susceptibility to SARS-CoV-2 Serological Response in Patients With Inflammatory Bowel Disease: Multinational Analysis From the ICARUS-IBD Consortium. Inflamm Bowel Dis. 2023;29(11):1693-1705. doi:10.1093/ibd/izad097Figure(s)/Table(s): see ne}, issn = {1873-9946} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_meiirene_2025, title = {Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutations}, author = {Mei, Irene and Nichterwitz, Susanne and Leboeuf, Melanie and Nijssen, Jik and Lenoel, Isadora and Repsilber, Dirk and Lobsiger, Christian S. and Hedlund, Eva}, year = {2025}, journal = {Genome Research}, volume = {35}, number = {9}, pages = {1975--1991}, doi = {10.1101/gr.279501.124}, url = {1990220}, language = {eng}, publisher = {Cold Spring Harbor Laboratory Press (CSHL)}, abstract = {Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motor neurons (MNs) that innervate skeletal muscles. However, certain MN groups including ocular MNs, are relatively resilient. To reveal key drivers of resilience versus vulnerability in ALS, we investigate the transcriptional dynamics of four distinct MN populations in SOD1G93A ALS mice using LCM-seq and single molecule fluorescent in situ hybridization. We find that resilient ocular MNs regulate few genes in response to disease. Instead, they exhibit high baseline gene expression of neuroprotective factors including En1, Pvalb, Cd63 and Gal, some of which vulnerable MNs upregulate during disease. Vulnerable motor neuron groups upregulate both detrimental and regenerative responses to ALS and share pathway activation, indicating that breakdown occurs through similar mechanisms across vulnerable neurons, albeit with distinct timing. Meta-analysis across four rodent mutant SOD1 MN transcriptome datasets identify a shared vulnerability code of 39 genes including Atf4, Nupr1, Ddit3, and Penk, involved in apoptosis as well as proregenerative and anti-apoptotic signature consisting of Atf3, Vgf, Ina, Sprr1a, Fgf21, Gap43, Adcyap1, and Mt1 Machine learning using genes upregulated in SOD1G93A spinal MN predicts disease in human stem cell-derived SOD1E100G MNs, and shows that dysregulation of VGF, INA, and PENK are strong disease-predictors across species and SOD1 mutations. Our study reveals MN population-specific gene expression and temporal disease-induced regulation that together provide a basis to explain ALS selective vulnerability and resilience and that can be used to predict disease.}, issn = {1088-9051} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_triantafylloucharisios_2025, title = {TRANSCRIPTOMIC ANALYSIS REVEALS A SYNERGY OF HYDROXYCHLOROQUINE AND GLUCOCORTICOIDS IN MODULATING B CELL-RELATED IMMUNE PROCESSES}, author = {Triantafyllou, Charisios and Lindblom, Julius and Beretta, Lorenzo and Parodis, Ioannis and Alarcón-Riquelme, Marta and Barturen, Guillermo}, year = {2025}, journal = {Journal of Rheumatology}, volume = {52}, number = {Suppl. 1}, pages = {144--145}, doi = {10.3899/jrheum.2025-0390.PV113}, url = {2014541}, language = {eng}, publisher = {The Journal of Rheumatology}, issn = {0315-162X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_erlandssonspeychalfelicia_2025, title = {Transcutaneous bilirubin in newborns before, during, and after home phototherapy— Results from a secondary analysis of a randomized controlled trial}, author = {Erlandsson Speychal, Felicia and Pettersson, Miriam and Eriksson, Mats and Odlind, Andreas and Ohlin, Andreas}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {3}, doi = {10.1371/journal.pone.0320067}, url = {1947854}, language = {eng}, publisher = {Public Library of Science (PLoS)}, keywords = {newborn infant; phototherapy}, abstract = {Home phototherapy is recommended as an alternative to hospital-based therapy for neonatal jaundice in otherwise healthy full-term infants. With a reliable device for transcutaneous bilirubin (TcB) measurement, bilirubin values could be monitored at home during treatment. This study aimed to examine the accuracy of TcB measurement of bilirubin levels before, during, and after home phototherapy. Patients requiring phototherapy were assigned to home (intervention) or hospital-based phototherapy (control). Transcutaneous bilirubin measurement was made at the sternum (uncovered skin) and at sacrum (covered by the diaper during treatment). Simultaneously, total serum bilirubin (TSB) level was collected through a blood sample. The agreement between TcB and TSB before, during, and after phototherapy was assessed using Bland-Altman plots. Altogether 141 patients and 856 paired bilirubin values were included. The results show that TcB measurements underestimate TSB levels. Before phototherapy, the mean difference between TcB and TSB was 75 ± 36 μmol/L at the sternum and 135 ± 39 μmol/L at sacrum, with no difference between study groups. During phototherapy, the mean difference at the sternum was larger in the control group, 105 ± 73 μmol/L, than in the intervention group, 50 ± 41 μmol/L; at sacrum, the mean difference was 125 ± 44 μmol/L, comparable in both study groups. After phototherapy, the TcB–TSB agreement improved, with a mean difference of 29 ± 33 μmol/L (sternum) and 87 ± 35 μmol/L (sacrum), and no difference between study groups. In conclusion this study shows that full-term infants who qualified for phototherapy show poor agreement between TcB measurement and TSB, suggesting that TcB measurements cannot replace measurement of TSB level before, during, or after home phototherapy.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_erlandssonspeychalfelicia_2025_1, title = {Transcutaneous bilirubin in newborns before, during, and after home phototherapy-Results from a secondary analysis of a randomized controlled trial}, author = {Erlandsson Speychal, Felicia and Pettersson, Miriam and Eriksson, Mats and Odlind, Andreas and Ohlin, Andreas}, year = {2025}, journal = {PLOS ONE}, volume = {20}, number = {3}, doi = {10.1371/journal.pone.0320067}, url = {1947486}, language = {eng}, publisher = {Public Library of Science (PLoS)}, abstract = {Home phototherapy is recommended as an alternative to hospital-based therapy for neonatal jaundice in otherwise healthy full-term infants. With a reliable device for transcutaneous bilirubin (TcB) measurement, bilirubin values could be monitored at home during treatment. This study aimed to examine the accuracy of TcB measurement of bilirubin levels before, during, and after home phototherapy. Patients requiring phototherapy were assigned to home (intervention) or hospital-based phototherapy (control). Transcutaneous bilirubin measurement was made at the sternum (uncovered skin) and at sacrum (covered by the diaper during treatment). Simultaneously, total serum bilirubin (TSB) level was collected through a blood sample. The agreement between TcB and TSB before, during, and after phototherapy was assessed using Bland-Altman plots. Altogether 141 patients and 856 paired bilirubin values were included. The results show that TcB measurements underestimate TSB levels. Before phototherapy, the mean difference between TcB and TSB was 75 ± 36 μmol/L at the sternum and 135 ± 39 μmol/L at sacrum, with no difference between study groups. During phototherapy, the mean difference at the sternum was larger in the control group, 105 ± 73 μmol/L, than in the intervention group, 50 ± 41 μmol/L; at sacrum, the mean difference was 125 ± 44 μmol/L, comparable in both study groups. After phototherapy, the TcB-TSB agreement improved, with a mean difference of 29 ± 33 μmol/L (sternum) and 87 ± 35 μmol/L (sacrum), and no difference between study groups. In conclusion this study shows that full-term infants who qualified for phototherapy show poor agreement between TcB measurement and TSB, suggesting that TcB measurements cannot replace measurement of TSB level before, during, or after home phototherapy.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mejasnihlntheodor_2025, title = {Transgender and Gender-Diverse Individual's Experiences of Openness and Concealment at Work in Sweden}, author = {Mejías Nihlén, Theodor and Lundberg, Tove and Wurm, Matilda and Malmquist, Anna}, year = {2025}, journal = {Scandinavian Journal of Psychology}, volume = {66}, number = {4}, pages = {598--610}, doi = {10.1111/sjop.13103}, url = {1947481}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {minority stress; non‐affirmation; stigmatization; transgender; work‐related health}, abstract = {The workplace is an important part of many people's lives. Many transgender and gender-diverse (TGD) individuals have negative experiences of their workplace due to discrimination and cisnormativity. Whether or not to be open about TGD experiences, and the degree of openness, is something many TGD individuals struggle with at work. Openness is related to well-being and job satisfaction and is therefore important to consider when understanding TGD individuals' work situations. This article examines TGD individuals' experiences of openness and concealment regarding their TGD experience at work. Thirty TGD adults from Sweden participated in online semi-structured interviews, which were analyzed using thematic analysis. Results show that the organizational climate and physical environment, as well as leadership and human resources, set the stage for an inclusive or excluding workplace for TGD individuals. For the individual, these aspects are taken into consideration when weighing up the risks and advantages of being open about their TGD experience at work. Factors such as work climate, the presence of LGBTQ+ colleagues, and access to safe facilities make a difference in the decision about, and experience of, being open or concealing one's TGD experience at work. Personal values, and a prerequisite to pass or not, affect decisions concerning disclosure and create different challenges in managing working life as a TGD individual. Findings are helpful in better understanding TGD people's situation at work and are of use for work management and policymakers in creating a better work environment for TGD individuals.}, issn = {0036-5564} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vonvogelsangannchristin_2025, title = {Translation, cultural adaptation, and psychometric properties of the MISSCARE survey OR - Swedish version}, author = {von Vogelsang, Ann-Christin and Falk-Brynhildsen, Karin and Erestam, Sofia and Leo Swenne, Christine and Torbjörnsson, Eva}, year = {2025}, journal = {BMC Nursing}, volume = {24}, number = {1}, doi = {10.1186/s12912-025-03548-1}, url = {1982336}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {missed nursing care; patient safety; perioperative nursing; psychometrics}, abstract = {BACKGROUND: Missing nursing care in the perioperative context affects quality of care and patient safety. More validated language versions of the MISSCARE Survey OR enable local, national, and international comparisons. The aim was to translate and culturally adapt the American MISSCARE Survey OR to the Swedish perioperative context and assess the instrument's psychometric properties.METHODS: A cross-sectional validation study with translation and cultural adaptation was conducted in eight steps according to the International Society for Pharmacoeconomics and Outcomes Research guidelines. To assess the psychometric properties, data were collected via a web survey distributed at a Swedish national conference for operating room nurses. The data collection was concluded in November 2023. Acceptability, construct validity and internal consistency were analyzed.RESULTS: Cultural adaptation resulted in the omission of two items from the section measuring missed elements of care. A total of 107 (out of 261 invited operating room nurses) respondents were included in the psychometric testing, leading to a response rate of 41%. Acceptability was high, and 95.3% of the respondents answered all the items. The factor analysis on missed elements of care was inconclusive and was therefore regarded as a list of nursing actions. With respect to reasons for missed nursing care, the factor analysis resulted in a three-factor solution, which explained a cumulative variance of 62.6%. The alpha coefficients for internal consistency for the three factors ranged from 0.760 to 0.947.CONCLUSIONS: The Swedish MISSCARE Survey OR is a valid instrument with sufficient psychometric properties and provides a reliable measure of missed nursing care and its reasons. Usage could be valuable for nursing managers and directors, who are responsible for care processes and strategic care planning.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_engayeinstom_2025, title = {Transverse optical gradient force in untethered rotating metaspinners}, author = {Engay, Einstom and Shanei, Mahdi and Mylnikov, Vasilii and Wang, Gan and Johansson, Peter and Volpe, Giovanni and Käll, Mikael}, year = {2025}, journal = {Light: Science & Applications}, volume = {14}, number = {1}, doi = {10.1038/s41377-024-01720-x}, url = {1926029}, language = {eng}, publisher = {Springer Nature}, abstract = {Nanostructured dielectric metasurfaces offer unprecedented opportunities to control light-matter momentum exchange, and thereby the forces and torques that light can exert on matter. Here we introduce optical metasurfaces as components of ultracompact untethered microscopic metaspinners capable of efficient light-induced rotation in a liquid environment. Illuminated by weakly focused light, a metaspinner generates torque via photon recoil through the metasurfaces' ability to bend light towards high angles despite their sub-wavelength thickness, thereby creating orbital angular momentum. We find that a metaspinner is subject to an anomalous transverse lateral optical gradient force that acts in concert with the classical gradient force. Consequently, when two or more metaspinners are trapped together in a laser beam, they collectively orbit the optical axis in the opposite direction to their spinning motion, in stark contrast to rotors coupled through hydrodynamic or mechanical interactions. The metaspinners delineated herein not only serve to illustrate the vast possibilities of utilizing optical metasurfaces for fundamental exploration of optical torques, but they also represent potential building-blocks of artificial active matter systems, light-driven micromachinery, and general-purpose optomechanical devices.}, issn = {2095-5545} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kerblomsophia_2025, title = {Traumatic Exposure and PTSD Symptoms in a Sample From a Tertiary Pain Clinic}, author = {Åkerblom, Sophia and Nordin, Linda and Zhao, Xiang}, year = {2025}, journal = {Pain Practice}, volume = {25}, number = {5}, doi = {10.1111/papr.70049}, url = {1959131}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, keywords = {ptsd; chronic pain; sociodemographic characteristics; traumatic experience; trauma‐related factors}, abstract = {BACKGROUND: Post-traumatic stress disorder (PTSD) is a significant psychiatric comorbidity in individuals with chronic pain. To date, the link between PTSD and chronic pain has mostly been described using the outdated DSM-IV PTSD criteria. Stronger evidence utilizing the updated DSM-5 criteria is needed to ensure comparability with earlier prevalence rates.METHODS: This observational study reported the percentage of individuals who had experienced at least one traumatic event and fulfilled the DSM-5 PTSD criteria, based on self-report, at a tertiary pain clinic in Sweden. The study also investigated the associations between PTSD symptom severity and sociodemographic characteristics, trauma-related factors, and pain-related factors, using regression analysis in the trauma-affected subsample.RESULTS: A large proportion of the sample (76.8%) reported having experienced at least one traumatic event, with the prevalence of self-reported PTSD being 23.0% for the sample. Female sex, being born outside of Sweden, anxiety, and multiple traumatic events were identified as significant predictors of more severe PTSD symptoms. The most common trauma types were accidents, life-threatening illness or injury, sudden accidental or violent death, and multiple traumas.CONCLUSIONS: Based on the results from this study, it seems important to integrate PTSD assessment in clinical settings focused on chronic pain. The findings align with the broader literature on the impact of sex, migration, and cumulative traumas as predictors of PTSD symptomatology. Furthermore, the results highlight the complex interconnection between PTSD and chronic pain, underscoring the importance of considering sociodemographic and trauma-related factors in the clinical assessment and treatment of chronic pain populations.}, issn = {1530-7085} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_elhajjvictorgabriel_2025_6, title = {Traumatic Vertebral Artery Injury After Subaxial Cervical Spine Injuries : Incidence, Risk Factors, and Long-Term Outcomes: A Population-Based Cohort Study}, author = {El-Hajj, Victor Gabriel and Habashy, Karl J. and Cewe, Paulina and Atallah, Elias and Singh, Aman and Fletcher-Sandersjöö, Alexander and Bydon, Mohamad and Fagerlund, Michael and Jabbour, Pascal and Gerdhem, Paul and Elmi-Terander, Adrian and Edström, Erik}, year = {2025}, journal = {Neurosurgery}, volume = {98}, number = {4}, pages = {881--891}, doi = {10.1227/neu.0000000000003173}, url = {1927514}, language = {eng}, publisher = {Wolters Kluwer}, abstract = {BACKGROUND AND OBJECTIVES: Vertebral artery injury (VAI) because of traumatic subaxial cervical spine injury is a rare but potentially devastating condition as it could lead to stroke. The aim of this study was to examine the incidence, risk factors, outcomes, and radiographic predictors of VAI in patients surgically treated for subaxial cervical spine injuries at a tertiary care trauma center.METHODS: This is a retrospective population-based cohort study, including all patients surgically treated for traumatic subaxial cervical spine injuries at the study center between 2006 and 2018. Primary outcomes included mortality and morbidity after the injury. Propensity score matching, survival, univariable, and multivariable analyses were used to study the outcomes of interest.RESULTS: Traumatic VAI primarily occurred after high-energy traumas such as motor vehicle accidents and falls from heights. The median age was 64.4 years (47.4-69.1), and 69% were male. In the cohort of patients with subaxial cervical injury, 54% had a spinal cord injury (SCI). In the subgroup with VAI, the frequency of SCI was 66% and a concomitant SCI and VAI were associated with a more severe American Spinal Cord Injury Association Impairment Scale grade (P = .015). However, after accounting for age, sex, and associated injuries, VAI did not affect postoperative complications, short- or long-term outcomes, or mortality rates. Facet joint dislocation was a unique radiographic predictor of VAI (odds ratio 3.8 [CI 1.42-10.7], P = .009).CONCLUSION: The findings suggest that clinical outcomes of patients with traumatic cervical spine injuries were not negatively affected by the presence of a VAI. Several radiographic factors were associated with VAI; however, only facet joint dislocation remained as an independent predictor of this injury.}, issn = {0148-396X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vonkobyletzkilaurab_2025, title = {Treatment for atopic dermatitis with Janus kinase inhibitors : useful recommendations from expert opinions}, author = {von Kobyletzki, Laura B. and Svensson, Åke}, year = {2025}, journal = {British Journal of Dermatology}, volume = {192}, number = {1}, pages = {8--8}, doi = {10.1093/bjd/ljae396}, url = {1908110}, language = {eng}, publisher = {Wiley-Blackwell Publishing Inc.}, issn = {0007-0963} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vonkobyletzkilaura_2025, title = {Treatment Patterns, Healthcare Utilization, and Related Costs for Prurigo Nodularis in Sweden}, author = {Von Kobyletzki, Laura and Metsini, Alexandra and Regnell, Simon E. and Carlberg, Michael and Svensson, Åke and Antelmi, Annarita}, year = {2025}, journal = {Acta Dermato-Venereologica}, volume = {105}, doi = {10.2340/actadv.v105.43730}, url = {1991952}, language = {eng}, publisher = {MJS Publishing}, keywords = {prurigo nodularis; costs; treatment patterns; healthcare resource utilization}, abstract = {Prurigo nodularis (PN) is a chronic, itchy, inflammatory skin condition that negatively affects quality of life. A study was undertaken to investigate the healthcare utilization, including treatment patterns and direct costs for specialist care, for PN in Sweden. Linkage cohorts were created from national Swedish patient and prescription registers, and the cost-per-patient database of PN adults in specialist care in Sweden from 2015 to 2020. Around 875 patients were registered annually with a specialist diagnosis of PN in Sweden, with 3,548 specialist visits per year on average. In patients with severe PN with AD, the most common treatment sequence was topical treatment with corticosteroids followed by systemic prednisolone and methotrexate (32.6%). More than one-fifth of individuals with PN, and most with severe PN, had treatment for more than 1 year. For in- and outpatient care, the mean cost per visit was €458.6 and per patient per year around €1,862. The total annual cost of PN patients is estimated to be €1.6 million in Sweden. A high proportion of patients are treated for years with several, often systemic, treatment sequels. Targeted treatments for PN might improve patients' quality of life and reduce the high related costs for the healthcare system.}, issn = {0001-5555} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_liedbergfredrik_2025_1, title = {Treatment Related to Urinary Tract Infections Is Associated with Delayed Diagnosis of Urinary Bladder Cancer : A Nationwide Population-based Study}, author = {Liedberg, Fredrik and Gårdmark, Truls and Hagberg, Oskar and Aljabery, Firas and Ströck, Viveka and Hosseini, Abolfazl and Malmström, Per-Uno and Söderkvist, Karin and Ullén, Anders and Jerlström, Tomas and Jahnson, Staffan and Holmberg, Lars and Häggström, Christel}, year = {2025}, journal = {European Urology Oncology}, volume = {8}, number = {1}, pages = {119--125}, doi = {10.1016/j.euo.2024.07.008}, url = {1889817}, language = {eng}, publisher = {European Association of Urology}, keywords = {bladder cancer; diagnostic delay; register-based study; urinary tract infection}, abstract = {BACKGROUND AND OBJECTIVE: It has been suggested that urinary tract infections (UTIs) are associated with delayed diagnosis of bladder cancer (BC). Our aim was to investigate prediagnostic treatments related to UTI and the relation to BC diagnostic delay, reflected by advanced disease at diagnosis. METHODS: We used data from the BladderBaSe 2.0 with data of treatments related to UTI up to 3 yr before BC diagnosis (2008-2019) for BC patients in comparison to a matched reference population. We investigated the association between UTI treatments and more advanced disease at diagnosis in the BC cohort. We used generalized ordered logistic regression to calculate odds ratios (ORs) for more advanced disease as an ordered outcome: non-muscle-invasive BC (NMIBC), muscle-invasive BC (MIBC), and metastatic BC (MBC). KEYFINDINGS AND LIMITATIONS: The study population included 29 921 BC patients and 149 467 matched reference subjects. The proportions of individuals receiving UTI treatment were higher in the patient groups than in the corresponding reference groups, with the greatest differences observed for the MIBC and MBC subgroups. The OR for the risk of more advanced disease (MIBC or MBC) with at least one UTI treatment versus none was 1.28 (95% confidence interval [CI] 1.19-1.37) for men and 1.42 (95 % CI 1.27-1.58) for women. The association to risk of more advanced disease increased with the number of UTI treatments for both sexes.CONCLUSIONS AND CLINICAL IMPLICATIONS: Further studies on the effects of treatments related to UTI in combination with other factors are needed to identify reasons for possible delays in the BC diagnostic pathway. PATIENT SUMMARY: We found that for patients with bladder cancer, previous antibiotic treatment for a urinary tract infection was linked to more advanced disease at diagnosis. Further studies are needed to identify reasons for possible delays in the diagnosis of bladder cancer.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gahrtoncaroline_2025, title = {Treatment uptake among individuals notified with HCV infection 1990-2022 in Sweden}, author = {Gahrton, Caroline and Kåberg, Martin and Lybeck, Charlotte and Lindahl, Karin and Patil, Snehal and Dalgard, Olav and Aleman, Soo and Duberg, Ann-Sofi}, year = {2025}, journal = {Infectious Diseases}, doi = {10.1080/23744235.2025.2569504}, url = {2005078}, language = {eng}, publisher = {Taylor & Francis}, keywords = {hepatitis c virus; sweden; elimination; people who inject drugs; surveillance}, abstract = {BACKGROUND: The WHO hepatitis C virus (HCV) elimination goal includes achieving ≥80% treatment coverage by 2030. OBJECTIVES: This study aims to assess Sweden's progress toward elimination by estimating national HCV treatment uptake and identifying associated factors.METHODS: This nationwide register-based study includes individuals notified with HCV infection in Sweden 1990-2022. Treatment uptake was defined as at least one dispensation of HCV treatment recorded in the Swedish Prescribed Drug Register (SPDR) by the end of 2023. As the SPDR was initiated in 2005, treatment uptake was specifically analyzed in individuals notified 2005-2022. Median time from notification to treatment was analyzed annually.RESULTS: Among 29,815 included individuals, 24,007 (81%) had started treatment. Among notified 2005-2022, treatment uptake was 81% (13,155/16,241) by 2022 and 85% (13,548/15,930) by 2023. Factors associated with lower odds of treatment uptake were: amphetamine use diagnosis (adjusted odds ratio 0.71; 95% confidence interval 0.60-0.83), opioid use diagnosis (0.71; 0.60-0.84), combined amphetamine/opioid use diagnoses (0.75; 0.62-0.91), other drug use diagnoses (0.70; 0.60-0.81), coinfection with hepatitis B virus (0.54; 0.39-0.76), male sex (0.73; 0.67-0.81) and ≤9 years of education (0.81; 0.70-0.94). The odds were higher in individuals aged ≥60 (1.26; 1.10-1.44) years. Median time to treatment was 2.8 months (IQR 1.7-5.6) among individuals notified in 2022.CONCLUSIONS: Sweden has reached the WHO treatment target, with treatment uptake ≥80%. In recent years, the median time to treatment has decreased to a few months. Continued efforts are needed to maintain this progress, particularly among people who inject drugs where HCV incidence remains high.}, issn = {2374-4235} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_fayeadams_2025, title = {Treatment-Free Outcomes Following Surgery for IBD : A Nationwide Cohort Study}, author = {Faye, Adam S. and Axelrad, Jordan and Sun, Jiangwei and Halfvarson, Jonas and Myrelid, Par and Söderling, Jonas and Olén, Ola and Ludvigsson, Jonas F.}, year = {2025}, journal = {Alimentary Pharmacology and Therapeutics}, doi = {10.1111/apt.70432}, url = {2008307}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {crohn's disease; inflammatory bowel disease; ulcerative colitis}, abstract = {BACKGROUND: Surgery in select individuals with inflammatory bowel disease (IBD) may obviate the need for future IBD-related treatment.AIMS: To characterise individuals who remain treatment-free during the first 5 years after initial IBD-related surgery.METHODS: We performed a nationwide cohort study using the Swedish National Patient Register and the ESPRESSO histopathology to identify individuals undergoing first IBD-related intestinal resection for Crohn's disease (CD) or total colectomy for ulcerative colitis (UC) between 2007 and 2018. We calculated adjusted odds ratios (aORs) for the need for any IBD-related therapy within the first 5 years post surgery.RESULTS: We included 1709 individuals with CD and 1010 with UC. At 5 years, 21.5% with CD and 42.4% with UC remained 'treatment free'. Being 'treatment free' 5 years after surgery was more common among patients with CD who had longer preoperative disease duration and older adults with UC. It was less common among individuals with extraintestinal manifestations of disease (CD aOR 0.64, 95% CI 0.43-0.97; UC aOR 0.48, 95% CI 0.31-0.73) and patients with CD who had chronic obstructive pulmonary disease.CONCLUSIONS: Surgery obviated the need for future therapy in 22% of patients with CD and 42% with UC. Absence of extraintestinal manifestations, older age in UC, and longer disease duration and absence of chronic obstructive pulmonary disease in CD may highlight an opportunity for precision surgery to identify those most likely to achieve long-term benefit from surgical intervention.}, issn = {0269-2813} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gomezalvaro_2025_3, title = {Treat-to-target in SLE : is serology important? Results from an integrated analysis of five randomised clinical trials of belimumab}, author = {Gomez, Alvaro and Lindblom, Julius and Parodis, Ioannis and Bertsias, George}, year = {2025}, journal = {Rheumatology}, volume = {64}, number = {6}, pages = {3598--3605}, doi = {10.1093/rheumatology/keaf107}, url = {1939654}, language = {eng}, publisher = {Oxford University Press}, keywords = {flares; low disease activity; nephritis; organ damage; prognosis; remission}, abstract = {OBJECTIVES: DORIS remission, based on clinical activity, and Lupus Low Disease Activity State (LLDAS), which includes serological markers, are protective targets in SLE. However, it remains unclear whether their prognostic impact is influenced by serum anti-dsDNA and complement levels.METHODS: We analysed data from five phase III trials (BLISS-52, BLISS-76, BLISS-SC, BLISS-NEA, EMBRACE) totalling 45 254 monthly visits. Generalized linear models evaluated the effects of DORIS/LLDAS -with or without active serology- on the risk for severe (BILAG ≥1A/2B) and renal (BILAG A/B) flares. Organ damage was also assessed.RESULTS: Normal serology occurred in 544/1871 (29.1%) DORIS and 1879/4760 (39.5%) LLDAS visits. Using no-DORIS as reference, DORIS with anti-dsDNA(-) or normal/high C3/C4 demonstrated stronger protection against severe flares (odds ratios[ORs] 0.042; 95% CI 0.005-0.331 and 0.216; 95% CI 0.094-0.494, respectively) compared with DORIS with anti-dsDNA(+) or low C3/C4 (ORs 0.511; 95% CI 0.284-0.919 and 0.528; 95% CI 0.261-1.067). Similarly, LLDAS with normal serology showed greater risk-reduction in severe flares compared with LLDAS with active serology, especially low C3/C4. For renal flares, DORIS with serological activity carried ∼6-fold higher risk compared with combined clinical/serological remission (OR 5.94; 95% CI 1.26-28.04). Damage accrual was lowest in patients with sustained DORIS and ≥1 visit showing anti-dsDNA(-) (0.8%) or normal C3/C4 (1.8%).CONCLUSION: Normal serology enhances the protection of DORIS and LLDAS against severe and renal SLE flares, possible reflecting deeper states of disease control. Patients with recently active disease who meet clinical targets but have persistently abnormal serology may require close monitoring to minimize flare-risk.}, issn = {1462-0324} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_murraygarret_2025, title = {Trends and challenges in research into the human aspects of ransomware : a systematic mapping study}, author = {Murray, Garret and Falkeling, Malin and Gao, Shang}, year = {2025}, journal = {Information and Computer Security}, volume = {33}, number = {2}, pages = {161--195}, doi = {10.1108/ICS-12-2022-0195}, url = {1885813}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {human aspects; ransomware; systematic mapping; trends; challenges; information security}, abstract = {Purpose: The purpose of this paper is to provide an overview of the trends and challenges relating to research into the human aspects of ransomware.Design/methodology/approach: A systematic mapping study was carried out to investigate the trends in studies into the human aspects of ransomware, identify challenges encountered by researchers and propose directions for future research. For each of the identified papers from this study, the authors mapped the year of publication, the type of paper, research strategy and data generation method, types of participants included, theories incorporated and lastly, the authors mapped the challenges encountered by the researchers.Findings: Fifty-nine papers published between 2006 and 2022 are included in the study. The findings indicate that literature on the human aspects of ransomware was scarce prior to 2016. The most-used participant groups in this area are students and cybersecurity professionals, and most studies rely on a survey strategy using the questionnaire to collect data. In addition, many papers did not use theories for their research, but from those that did, game theory was used most often. Furthermore, the most reported challenge is that being hit with ransomware is a sensitive topic, which results in individuals and organisations being reluctant to share their experiences.Research limitations/implications: This mapping study reveals that the body of literature in the area of human aspects of ransomware has increased over the past couple of years. The findings highlight that being transparent about ransomware attacks, when possible, can help others. Moreover, senior management plays an important role in shaping the information security culture of an organisation, whether to have a culture of transparency or of secrecy.Originality/value: This study is the first of its kind of systematic mapping studies contributing to the body of knowledge on the human aspects of ransomware.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_molariusanu_2025, title = {Trends in obesity prevalence by gender and educational level among adults in Mid-Sweden between 2012 and 2022}, author = {Molarius, Anu and Karlsson, Jan}, year = {2025}, journal = {Journal of Epidemiology and Community Health}, volume = {79}, number = {3}, pages = {216--219}, doi = {10.1136/jech-2024-222665}, url = {1908095}, language = {eng}, publisher = {BMJ Publishing Group Ltd}, keywords = {education; health inequalities; obesity; public health}, abstract = {BACKGROUND: The aim was to investigate trends in obesity prevalence by gender and educational level in the general population aged 30-69 years, based on large surveys conducted in Mid-Sweden in 2012, 2017 and 2022.METHODS: The study included 22 082, 15 264 and 17 055 respondents, respectively. Obesity (body mass index ≥30 kg/m2) was based on self-reported weight and height. Trends in obesity prevalence, including comparisons across educational levels, were estimated by age-standardised proportions with corresponding 95% CIs. Differences between genders, educational levels and survey years were tested using multiple logistic regression.RESULTS: The overall age-standardised prevalence of obesity increased from 17.6% in 2012 to 20.1% in 2017 and to 23.3% in 2022. There was no statistically significant difference in obesity prevalence between men and women. Large and persisting inequalities between educational levels were however observed. In 2022, the prevalence of obesity was about 30% among persons with low/middle education and 18% among persons with high education.CONCLUSION: Efforts to tackle the obesity epidemic are urgently required in Sweden, taking into consideration the circumstances of groups with low and middle levels of education.}, issn = {0143-005X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sagerforsmarcus_2025_1, title = {Trends in spasticity-reducing surgery and botulinum toxin treatment for post-stroke spasticity : a register study on 6,258 patients in Sweden, 2010-2021}, author = {Sagerfors, Marcus and Blaszczyk, Izabela and Chemnitz, Anette and Johansson, Helena and Strömberg, Joakim}, year = {2025}, journal = {Journal of Rehabilitation Medicine}, volume = {57}, doi = {10.2340/jrm.v57.42684}, url = {1946342}, language = {eng}, publisher = {Foundation for Rehabilitation Information}, keywords = {botulinum toxin; spasticity; stroke; tendon transfer; extremity surgery}, abstract = {Spasticity is characterized by increased muscle tone, which can result in pain, contractures, impaired hygiene, and deformities. Stroke is a leading cause of paresis, and nearly 40% of stroke patients will develop spasticity.OBJECTIVE: To assess trends in upper and lower extremity spasticity-reducing surgery and botulinum toxin A (BoNT-A) treatment. DESIGN: A national cohort register study.METHODS: Upper and lower extremity spasticity-reducing surgery and BoNT-A treatment in Swedish stroke patients over a 12-year period was assessed using the National Patient Register.RESULTS: A total of 6,258 patients were treated during this period; their mean age was 58, and the majority were male. In both upper and lower extremities, tenotomy was the most common surgical procedure, followed by tendon lengthening. The need for BoNT-A injections was significantly reduced after surgery compared with before surgery. The total number of BoNT-A treatments increased during the study period, and ultrasound guidance of injections became more common.CONCLUSION: The frequency of BoNT-A treatments was significantly reduced in patients who underwent surgery. Even though no causative association can be established due to the nature of these registry data, this may indicate that surgery reduces the need for further BoNT-A treatments.}, issn = {1650-1977} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_chanelizabethsm_2025, title = {Triarchic traits as risk versus protective factors for ADHD symptomatology : A prospective longitudinal investigation}, author = {Chan, Elizabeth S. M. and Perkins, Emily R. and Bertoldi, Bridget M. and Lowman, Kelsey L. and Soto, Elia F. and Tuvblad, Catherine and Oskarsson, Sofi and Baker, Laura A. and Patrick, Christopher J.}, year = {2025}, journal = {Development and psychopathology (Print)}, volume = {37}, number = {1}, pages = {303--314}, doi = {10.1017/S0954579423001608}, url = {1832952}, language = {eng}, publisher = {Cambridge University Press}, keywords = {attention-deficit/hyperactivity disorder; developmental psychopathology; positive youth development; protective factor; triarchic model}, abstract = {Attention-deficit/hyperactivity disorder (ADHD) symptoms are associated with myriad adverse outcomes, including interpersonal difficulties, but factors that moderate the developmental course and functional impact of ADHD over time are not well understood. The present study evaluated developmental contributions of the triarchic neurobehavioral traits (boldness, meanness, and disinhibition) to ADHD symptomatology and its subdimensions from adolescence to young adulthood. Participants were twins and triplets assessed at ages 14, 17, and 19 (initial N = 1,185, 51.2% female). Path analyses using negative binomial regression revealed that boldness at age 14 was associated with more ADHD symptoms cross-sectionally (especially hyperactivity/impulsivity), but fewer symptoms (especially inattention) at age 19 in the prospective analysis. Notably, inclusion of interpersonal problems at ages 14 and 17 as covariates reduced the latter effect to nonsignificant. Disinhibition concurrently and prospectively predicted higher levels of ADHD symptoms, including both subdimensions, and the prospective effects were partially mediated by greater social impairment at age 17. Meanness prospectively (but not concurrently) predicted higher levels of hyperactivity/impulsivity symptoms. Sex moderated certain associations of meanness and disinhibition with ADHD symptoms. These findings highlight how fundamental neurobehavioral traits shape both psychopathology and adaptive outcomes in the developmental course of ADHD.}, issn = {0954-5794} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_farhatluisc_2025_2, title = {Trichotillomania and Risk of Alcohol- and Drug-Related Problems}, author = {Farhat, Luis C. and Isomura, Kayoko and Kuja-Halkola, Ralf and Brikell, Isabell and Chang, Zheng and D'Onofrio, Brian M. and Larsson, Henrik and Lichtenstein, Paul and Fernández de la Cruz, Lorena and Sidorchuk, Anna and Mataix-Cols, David}, year = {2025}, journal = {Biological Psychiatry: Global Open Science}, volume = {5}, number = {6}, doi = {10.1016/j.bpsgos.2025.100605}, url = {2009481}, language = {eng}, publisher = {Elsevier}, keywords = {cohort studies; disruptive; impulse control; and conduct disorders; hair-pulling disorder; obsessive-compulsive disorder; registries; substance-related disorders}, abstract = {BACKGROUND: Trichotillomania is an understudied psychiatric disorder characterized by repeated hair-pulling resulting in hair loss. Little is known about the risk of problematic substance use in this patient group. In this nationwide matched cohort study, we investigated the association between trichotillomania and substance-related problems.METHODS: We linked various nationwide administrative and clinical registers in Sweden. Among 12,015,664 individuals living in the country from January 1, 1997, to December 31, 2020, we identified 1136 individuals with an ICD-10 diagnosis of trichotillomania at age ≥10 years (86.4% female, median age at first diagnosis 23.8 years [interquartile range 13.3-34.9 years]) and matched them with 11,360 unaffected individuals. The outcome was broadly defined as substance-related problems (alcohol- and drug-related disorders, suspected criminal offenses, and deaths). Stratified Cox proportional hazards regression was used to determine hazard ratios (HRs) for the association between trichotillomania and any substance-related problems.RESULTS: Over a mean follow-up period of 6 years, substance-related problems were recorded for 137 (12.1%) individuals with trichotillomania and 399 (3.5%) matched individuals (crude incidence rates per 1000 person-years of 21.6 and 5.6, respectively). After controlling for sociodemographic covariates and parental substance-related problems, trichotillomania was associated with an increased relative risk of substance-related problems (HR, 3.12; 95% CI, 2.53-3.85). Adjusting also for comorbid psychiatric history did not meaningfully change the findings.CONCLUSIONS: Individuals with trichotillomania had a 3-fold increased risk of substance-related problems compared with unaffected individuals. Future research should examine the mechanisms underlying this association and inform the clinical management of the dual diagnoses.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_borgtomas_2025, title = {Trochanteric hip fractures treated surgically-outcome in a ten-year cohort of 46,121 patients from the Swedish National Hip Fracture Registry}, author = {Borg, Tomas and Forssten, Maximilian Peter and Mohammad Ismail, Ahmad and Cao, Yang and Mohseni, Shahin}, year = {2025}, journal = {OTA international : the open access journal of orthopaedic trauma}, volume = {8}, number = {1}, doi = {10.1097/OI9.0000000000000358}, url = {1933317}, language = {eng}, publisher = {Wolters Kluwer Health}, abstract = {OBJECTIVES: To compare postoperative mortality regarding 2 techniques in the treatment of trochanteric hip fractures (THFs). DESIGN: Retrospective cohort study. SETTING: National databases.PATIENTS: All consecutive surgically treated THF cases between 2008 and 2017 were included. Pathological fractures or patients younger than 60 years were excluded.INTERVENTION: Patients were grouped based on the surgical technique: sliding hip screw (SHS) or intramedullary (IM) nail. This data set was cross-referenced with a National Board of Health and Welfare's patient registry and a Cause of Death registry.MAIN OUTCOME MEASUREMENTS: Mortality, comorbidities, and length of stay (LOS).RESULTS: Forty-six thousand one hundred twenty-one cases were included. Twenty-five thousand eight hundred seventy-seven patients received a SHS, and 20,244 received an IM nail. Patients in the IM group were more often female (71.8% vs. 69.2%, P < 0.001), slightly less fit for surgery (American Society of Anesthesiologists score ≥3: 61.2% vs. 60.1%, P = 0.003), and more frail (Orthopedic Frailty Score ≥2: 54.2% vs. 52.8%, P = 0.005). Multifragment fractures were more prevalent in the IM nail group (66.6% vs. 32.0%, P < 0.001), which suffered from a higher comorbidity burden. After adjusting for potential confounders, no clinically significant differences in 7-day, 30-day, 90-day, or 1-year postoperative mortality were observed. Subgroup analyses focusing on 2-fragment and multifragment fractures could not detect any difference in mortality. LOS was 1 day shorter for the IM nail group as a whole.CONCLUSIONS: Based on 10 years of data including 46,121 patients with THF managed with SHS or IM nail, no difference was observed in mortality up to 1 year postoperatively, when comparing surgical technique. LOS was shorter for the IM nail group.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_strmjonaseriksson_2025, title = {Troponin levels in COPD without cardiovascular influence : SCAPIS findings}, author = {Ström, Jonas Eriksson and Pesonen, Ida and Liv, Per and Andersson, Anders and Ekström, Magnus and Holm, Jonas and Janson, Christer and Nilsson, Ulf and Sundh, Josefin and Sköld, Magnus and Blomberg, Anders}, year = {2025}, journal = {European Respiratory Journal}, volume = {66}, number = {69}, doi = {10.1183/13993003.congress-2025.OA4455}, url = {2037262}, language = {eng}, publisher = {European Respiratory Society}, abstract = {Background: Low-level troponin elevations are common in cardiovascular disease (CVD). In COPD, similar elevations have been observed in patients without CVD, suggesting non-ischemic mechanisms. However, prior studies had small samples and limited adjustments for subclinical CVD.Aim: To examine whether high-sensitivity troponin I (hs-TnI) is associated with obstructive phenotypes or FEV₁/FVC in subjects without CVD or subclinical coronary artery disease (CAD) identified by coronary artery calcification scoring (CACS).Design: Cross-sectional analysis of 22,526 subjects (age 50–64 yrs), without self-reported CVD or CACS >100, from the Swedish CArdioPulmonary bioImage Study. Hs-TnI was categorized into five levels: below the limit of detection (LoD) and quartiles above LoD. Multivariable regression models adjusted for potential confounders tested associations between hs-TnI and chronic airflow limitation (CAL), COPD, COPD with emphysema or FEV₁/FVC.Results: Adjusted regression estimates showed no significant associations between hs-TnI and obstructive phenotypes or FEV₁/FVC. In COPD, the highest quartile had an adjusted OR of 0.75 (95% CI: 0.54, 1.02) vs. below LoD, with similar patterns for CAL and COPD with emphysema. Median hs-TnI was 1.62 ng/L in COPD and 1.60 ng/L in non-obstructive.Conclusion: In this large cohort, hs-TnI was not associated with COPD, other obstructive phenotypes, or FEV₁/FVC after accounting for CVD and subclinical CAD. These findings suggest that non-ischemic mechanisms do not meaningfully contribute to troponin elevations in mild–moderate COPD. Clinically, elevated hs-TnI in COPD patients without known CVD should prompt evaluation for subclinical CVD rather than be attributed to COPD alone.}, issn = {0903-1936} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sderquistbo_2025_1, title = {Trough levels of dalbavancin during long-term treatment of prosthetic joint infections}, author = {Söderquist, Bo and Möller, Max and Salihovic, Samira}, year = {2025}, journal = {Infectious Diseases}, volume = {57}, number = {10}, pages = {913--919}, doi = {10.1080/23744235.2025.2499144}, url = {1956043}, language = {eng}, publisher = {Taylor & Francis}, keywords = {bone and joint infections; dalbavancin; lipoglycopeptides; prosthetic joint infections; therapeutic drug monitoring}, abstract = {INTRODUCTION: Dalbavancin is a lipoglycopeptide with an exceptionally long half-life that allows simplified administration, which may be of value in long-term treatment of bone and joint infections, such as prosthetic joint infections (PJIs). The objective was to determine trough (Cmin) values of dalbavancin during long-term PJI treatment according to the recommendation of the Swedish National Guidelines for Bone and Joint Infections: a loading dose of 1,500 mg on day 1 and another 1,500 mg on days 8-14, followed by day 28 administration of 1,000 mg every two weeks or 500 mg per week. PATIENTS/METHODS: Twelve patients with PJI treated with at least six doses of dalbavancin were prospectively followed up, serum samples were collected, and renal function was investigated. Dalbavancin concentrations were measured using ultra-high pressure liquid chromatography coupled with unispray tandem mass spectrometry (UHPLC-MS/MS).RESULTS: The median serum concentration (Cmin) 14 days after the first 1,500 mg dose was 36.3 mg/L (range: 6.6-62.4 mg/L). The median trough value at the date of the last given dose (1,000 mg) after a total of 6-7 doses was 53.6 mg/L (range: 32.0-97.5 mg/L). Three patients showed a tendency towards successive accumulation of dalbavancin during treatment. None of the patients showed any significant impairment in renal function.CONCLUSIONS: Therapeutic drug monitoring during long-term dalbavancin treatment is recommended to avoid the risk of accumulation and unnecessarily high trough levels. In many cases, such monitoring can allow the dosing interval to be extended.}, issn = {2374-4235} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hugeliuskarin_2025_1, title = {Trust : an essential component in nursing crisis leadership; a hybrid concept analysis}, author = {Hugelius, Karin}, year = {2025}, journal = {BMC Nursing}, volume = {24}, number = {1}, doi = {10.1186/s12912-025-02748-z}, url = {1931322}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {disasters; emergencies; leadership; nursing administration research; nursing care management; nursing staff; trust}, abstract = {BACKGROUND: Given the increasing trend of disasters, terrorist attacks, pandemics and other crises, crisis leadership is crucial for nurses who lead others and for those working in such situations. There is a need to define and explore the concept of trust as a component of crisis leadership in nursing. This concept analysis aimed to explore the concept of trust in crisis leadership from a nursing perspective.METHODS: A hybrid concept analysis was conducted. The method consisted of three phases: (I) a theoretical phase relying on a structured literature search, including 11 scientific publications; (II) a field-work phase, in which qualitative thematic analysis of interviews with 30 nurses who had been deployed and/or had led others during crises, was conducted and (III) a final analytic phase, where the results from these data collections were merged.RESULTS: The analysis suggested that the fundamentals of trust included a perceived intention to do good, the capabilities of both the leader and the team and the perceived predictability of the leader's behaviour. Trust was found to be built on a perceived forward-looking direction, self-trust and the personal attributes of the leader, such as ethical conduct, the ability to predict the development of crises and an intention to take responsibility and be honest. The social attributes of the relationship between the leader and the team included the intention not to leave anyone behind, loyalty and fostering a sense of belonging among team members. The organisational attributes included a clear organisational structure and clarity of mandate.CONCLUSIONS: Trust is an essential component of crisis leadership that depends on a leader's perceived intention to do good, predictability of the leader's behaviour and the capabilities of both the leader and the team. The development of trust relies on the personal attributes of the leader, the social relationship between the leader and the team and organisational attributes. Nurses appointed to lead others during a crisis need to understand the fundamentals of trust as part of leadership in highly demanding situations. Thus, it can be argued that being a leader in a crisis situation requires distinct personal and professional attributes and skills compared to those used to meet routine demands.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lim_2025, title = {Trust in a Decentralized World : Data Governance From Faithful, Private, Verifiable, and Traceable Data Feeds}, author = {Li, M. and Chen, Y. and Qiao, Y. and Ye, G. and Zhang, Z. and Zhu, L. and Conti, Mauro}, year = {2025}, journal = {IEEE Transactions on Information Forensics and Security}, volume = {20}, pages = {10818--10833}, doi = {10.1109/TIFS.2025.3615705}, url = {2028273}, language = {eng}, publisher = {IEEE}, keywords = {blockchain; faithful data feeds; security; tee; verifiable computation}, abstract = {Blockchain technology autonomously executes smart contracts that require external data to facilitate specific applications, underscoring the necessity for Authenticated Data Feeds (ADF). Existing solutions fall short in providing genuine authentication of data, lack private and verifiable computations across multiple data sources, and overlook data traceability, rendering current systems inadequate for complex applications. We present WuKong (WK), a data governance system that offers authenticated, privately verifiable, and traceable data feeds. WK enables a server to collect faithful data through an oracle committee and to prove computation correctness in zero-knowledge proofs, and empowers legal entities to trace a leakage source conditionally. We formally define and prove the security of \\textsf WK in the universal composability framework. We implement three applications that seamlessly integrate with WK. Experimental results indicate that \\textsf WK effectively liberates sensitive data from distributed, untrusted, and anonymous providers, making it accessible to various services and establishing trust in a decentralized world.}, issn = {1556-6013} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_mitedarja_2025, title = {Trust vs. Control : Comparing Flexible and Restrictive Hybrid Work Policies in Two Software Companies}, author = {Šmite, Darja and Moe, Nils Brede and Chatzipetrou, Panagiota and Godliauskas, Povilas and Helland, Per Kristian and Tkalich, Anastasiia}, year = {2025}, pages = {535--545}, doi = {10.1145/3756681.3756965}, url = {2026390}, language = {eng}, publisher = {The Association for Computing Machinery}, keywords = {remote; flexible; hybrid; wfh; locational flexibility; well-being; human aspects; behavioral software engineering; formal control; informal control; trust; empirical study; survey}, abstract = {The pandemic experiences of forced work from home (WFH) in the tech industry turned out better than expected. As a result, modern workplaces that employ software engineers have become increasingly hybrid allowing employees to alternate days spent in the office with days spent working remotely. Yet, approaches to regulate the hybrid work arrangements vary. Some companies implemented strict policies with controlled office presence while others rely on recommendations and permit greater locational flexibility. In this paper, we evaluate how different degrees of locational flexibility influence individual work arrangements and satisfaction in two comparative cases: a company with high degree of flexibility (FinCo) and a company with mandatory office presence (TelCo). Through a survey of 547 practitioners, our findings reveal that flexible policies can achieve higher voluntary office attendance than mandatory requirements. To our surprise, we found that the number of employees visiting the office at least 2-3 days per week in the company with greater flexibility was higher (68%) compared to the company with mandatory attendance (58%). The study also identifies key factors influencing work location choices, including commute time and role. The type of tasks and dependencies with colleagues also matter - employees with more WFH days tended to have more individual tasks, while those with more onsite work days engaged in more collaborative tasks and had colleagues who depended on them. Our results suggest that trust-based approaches and creating attractive office environments may be more effective than strict attendancepolicies in maintaining desired office presence while supporting employee satisfaction. These findings contribute practical insights for organizations seeking to establish effective post-pandemic wor kpolicies for software engineers.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gustafssonkarinm_2025_1, title = {Trusting Climate Science : The Process of Accepting What Is True About the Climate Crisis and Simultaneously Creating Social Order}, author = {Gustafsson, Karin M}, year = {2025}, journal = {Nature and Culture}, volume = {20}, number = {3}, pages = {177--200}, doi = {10.3167/nc.2025.200301}, url = {2017904}, language = {eng}, publisher = {Berghahn Journals}, keywords = {acceptance; environmental youth movement; knowledge production; science–public relations; social order; trust}, abstract = {This article develops a theoretical framework for trust in science. The framework is created to facilitate analysis of the growing environmental youth movement’s trust in and relation to climate science. This article provides a critical review of previous theoretical discussions of trust in science–public relations and recontextualizes and continues the discussion. This is accomplished by adopting a discourse analytical perspective on trust, knowledge production, and the construction of social order. The study shows how trust and the assessment of trustworthiness lie at the core of knowledge production and the construction of social order as well as how a problematization of trust as a truth-accepting practice is essential to understanding the growing environmental youth movement and its relation to science.}, issn = {1558-6073} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_stjohnoliver_2025_2, title = {Trusting parents : The tale of two schools}, author = {St John, Oliver and Ålander, Jonas}, year = {2025}, pages = {405--405}, url = {2032332}, language = {eng}, keywords = {trust; parents; expectations; collaboration; family support worker; parent-set meeting agendas}, abstract = {In Sweden, school personnel are given a strong curricular mandate to “cooperate with the pupils’ parents to develop school content and work together”. Despite the envisioned democratic and performative advantages of this mission, there is no approved universal practice for successful cooperation between school and home. Research also points to various factors hindering cooperative efforts and “schools struggle to promote an effective dialogue between teachers and parents around the educational support needs of the student” (Gerdes et al., 2022). Communicative and cooperative engagement is particularly difficult for many parents with immigrant backgrounds who are made vulnerable by majority cultural norms and resources. This presentation reports on a project that aims to understand and develop two schools’ strategic initiatives to strengthen their cooperation with parents and thereby improve conditions for pupils’ development and learning. One school’s model centres around the educational contribution of a family support worker (FSW) while the other school has developed a network of trust-building NET-meetings with a parent-set agenda as well as ambassadors who give parents a voice. Theoretical framework: Georg Simmel (1950) defines trust as “a hypothesis certain enough to serve as a basis for practical conduct” (p. 318). The notion of hypothesis clarifies that without comprehensive knowledge about a person we cannot rationally justify our actions in relation to the person. He describes trust as personal confidence or faith in another person that resolves the problem of partial knowledge by bridging the gap between available and unavailable knowledge. Simmel (1950) also teaches us that confidence given to others in a group is a morally potent force almost compelling recipients to live up to the trust invested in them.  Methodology/Research design: The project’s research design is practice-based with a commitment to depart from problems that schools are facing and develop practice to manage them. To capture the voices of both parents and teachers and explore respondent-relevant issues, a sequence of questionnaires, teacher written reflections, group and individual interviews build on each other successively to form a progressive and integrated research design. Expected findings: Both school’s cooperative models provide neutral ground, “outside-yet-inside” environments enabling parents to engage with school personnel, make parents visible in the school community and create conditions for parents to support their children with their schooling. Hope and trust among parents in the school as an institution is seen as mediated by the confidence of school personnel in parents as parents of the school’s pupils and as individuals, by open-ended dialogic engagement with parents and by parent networks.  Relevance to Nordic educational research: This presentation will help clarify Swedish conceptualizations of the educational turn to parents and promote greater understanding of its relevance internationally. Second, while the perspectives of parents are frequently absent in this research field, this study is committed to profiling the voices of parents on family – school issues. Third, while trust is rarely researched as a phenomenon in the field, this study aims to investigate the nature of trust and how it can be developed between schools and parents. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_primusroberts_2025_3, title = {Två svenska pragmatiker formas : En jämförelse av Sven-Göran Erikssons och Pia Sundhages tränarfilosofier}, author = {Primus, Robert S. and Svensson, Daniel}, year = {2025}, journal = {Idrott, historia & samhälle}, doi = {10.61684/ihs.2024.33949}, url = {1937961}, language = {swe}, publisher = {Svenska idrottshistoriska föreningen}, keywords = {sven-göran eriksson; pia sundhage; svensk fotboll; tränarfilosofi}, abstract = {Alltsedan den moderna tävlingsidrottens födelse har svenska ledare haft en betydande inverkan på den internationella idrotten, och svenska forskare och entreprenörer har bidragit till utvecklingen av träning och coaching. Men när det kommer till fotboll har Sverige snarare tagit intryck från andra. Det finns ett antal undantag från denna relativa anonymitet och bland dessa är det två namn som lyser extra starkt – Sven-Göran Eriksson och Pia Sundhage. Båda har haft långa och framgångsrika karriärer som har fört svenska tränarideal till en internationell publik. Syftet med denna studie är att undersöka hur deras respektive tränarfilosofier har utvecklats över tid och hur de har formats av utbildning, tidigare erfarenheter och influenser i coachernas egna liv. Utvecklingen av Erikssons och Sundhages tränarfilosofier analyseras utifrån teorier om vetenskapliggörande, specialisering och professionalisering. Vi bygger på deras egna publikationer, intervjuer och tränarutbildningsmaterial.}, issn = {0280-2775} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_coventrylindal_2025, title = {Twenty-one year trends in pressure injury in a Western Australian hospital}, author = {Coventry, Linda L. and Kabdebo, Istvan and Walsh, Nicole and Winderbaum, Joelle and Jenkins, Mark and Kaistha, Prachi and Twigg, Diane E. and Jansen, Shirley and Beeckman, Dimitri}, year = {2025}, journal = {Journal of tissue viability}, volume = {34}, number = {2}, doi = {10.1016/j.jtv.2025.100878}, url = {1941710}, language = {eng}, publisher = {Elsevier}, issn = {0965-206X} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_29, title = {Tydligare regler för inkomstbeskattning av utrikes bosatta}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031705}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 13 mars 2024 kom regeringens proposition 2024/25:128 om ändringar i lagen om särskild inkomstskatt för utomlands bosatta (1991:586), SINK. Eleonor Kristoffersson, professor i skatterätt, analyserar förslaget.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_pankratovamaryna_2025, title = {Ultrafast demagnetization dynamics of 4f antiferromagnets}, author = {Pankratova, Maryna and Borisov, Vladislav and Thonig, Danny and Pathak, Rohit and Windsor, Yoav William and Rettig, Laurenz and Eriksson, Olle and Ernst, Arthur and Bergman, Anders}, year = {2025}, journal = {Physical Review Materials}, volume = {9}, number = {9}, doi = {10.1103/rjvq-qs9x}, url = {2004720}, language = {eng}, publisher = {American Physical Society}, abstract = {We study the ultrafast demagnetization dynamics of LnRh2Si2 (Ln = Pr, Nd, Sm, Gd, Tb, Dy, Ho) antiferromagnets after excitation by a laser pulse, using a combination of density functional theory and atomistic spin and spin-lattice dynamics simulations. In the first step, we calculate the Heisenberg interactions using the magnetic force theorem and compare two approaches, where the 4 f states of the rare earths are treated as frozen core states or as valence states with added correlation corrections. We find marked quantitative differences in terms of predicted Curie temperature for most of the systems, especially for those with a large orbital moment of the rare-earth cations. This can be attributed to the importance of indirect interactions of the 4 f states through the Si states, which depends on the binding energy of the 4 f states and coexists with Ruderman-Kittel-Kasuya-Yosida-type interactions mediated by the conduction states. However, qualitatively both approaches agree in terms of the predicted antiferromagnetic ordering at low temperature, which is in line with previous experiments. In the second step, the atomistic dynamics simulations are used in combination with a heat-conserving two-temperature model, which allows for the calculation of spin and electronic temperatures during the magnetization dynamics simulations. Our simulations demonstrate that despite quite different demagnetization times, magnetization dynamics of all studied LnRh2Si2 antiferromagnets exhibit similar two-step behavior, in particular the first fast drop followed by slower demagnetization. In addition, we observe that the demagnetization amplitude depends linearly on laser fluence, for low fluences, something that is also in agreement with experimental observations. We also investigate the impact of lattice dynamics on ultrafast demagnetization using coupled atomistic spin-lattice dynamics simulations and the heat-conserving three-temperature model, which confirm the linear dependence of magnetization on laser fluence. The microscopic mechanisms behind these behaviors are investigated in detail.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lucidarmejay_2025, title = {Umrah- and travel-associated meningococcal disease due to multiple serogroup W ST-11 sub-strains pre-Hajj 2024}, author = {Lucidarme, Jay and Deghmane, Ala-Eddine and Sharma, Shalabh and Meilleur, Courtney and Eriksson, Lorraine and Mölling, Paula and Claus, Heike and van Sorge, Nina M. and Bettencourt, Célia and Bajanca-Lavado, Paula and Tsang, Raymond S. W. and Caugant, Dominique A. and Stefanelli, Paola and Neri, Arianna and Tzanakaki, Georgina and Lekshmi, Aiswarya and Campbell, Helen and Clark, Stephen A. and Heymer, Emma J. and Ribeiro, Sonia and Willerton, Laura and Walsh, Lloyd and Bai, Xilian and Lâm, Thiên-Trí and Wagle, Basanta R. and Walia, Vishakh and Howie, Rebecca L. and Neatherlin, John and Rubis, Amy and Vachon, Madhura and McNamara, Lucy A. and Ladhani, Shamez N. and Taha, Muhamed-Kheir and Borrow, Ray}, year = {2025}, journal = {Journal of Infection}, volume = {91}, number = {4}, doi = {10.1016/j.jinf.2025.106558}, url = {1991208}, language = {eng}, publisher = {Elsevier}, keywords = {hajj; hajj strain sublineage; meningococcal serogroup w; outbreak; st-11 clonal complex; umrah}, abstract = {OBJECTIVES: Collectively, the Hajj and Umrah pilgrimages draw >30 million pilgrims to the Kingdom of Saudi Arabia (KSA) each year. Before Hajj 2024 (14 to 19 June), the meningococcal serogroup W ST-11 complex (W:cc11) Hajj-strain sublineage caused multiple international cases of invasive meningococcal disease (IMD) associated with travel to the Middle East and Asia. Here we identify the strains responsible.METHODS: All Hajj strain sublineage genomes on PubMLST.org underwent core genome MLST comparisons (PubMLST.org).RESULTS: Isolates from 30 cases, across seven countries, formed five phylogenetic clusters within two distinct strains. Travel histories included KSA, other Middle Eastern countries, India, Mauritius, via Turkey, and no known associated travel. The prevalent strain, representing four clusters, had no African, and limited Middle Eastern, representation. The geo-temporal distribution of available genomes suggested Eastern Europe as a possible source.CONCLUSIONS: The rapid expansion of Umrah/travel-related W:cc11 IMD cases in early 2024 was due to multiple strains/sublineages. Despite the involvement of non-KSA travel-destinations, the coincidence of cases with the busy month of Ramadan, and the abrupt cessation during Hajj (when vaccine compliance is maximal), suggest that Umrah was a key driver and highlight the need to reinforce mandatory vaccination whilst maintaining global vigilance.}, issn = {0163-4453} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tunedalkajsa_2025, title = {Uncertainty in cardiovascular digital twins despite non-normal errors in 4D flow MRI : Identifying reliable biomarkers such as ventricular relaxation rate}, author = {Tunedal, Kajsa and Ebbers, Tino and Cedersund, Gunnar}, year = {2025}, journal = {Computers in Biology and Medicine}, volume = {188}, doi = {10.1016/j.compbiomed.2025.109878}, url = {1939665}, language = {eng}, publisher = {Elsevier}, keywords = {4d flow mri; biomarkers; brachial pressure; cardiovascular; lumped parameter model; mechanistic model; uncertainty}, abstract = {Cardiovascular digital twins and mechanistic models can be used to obtain new biomarkers from patient-specific hemodynamic data. However, such model-derived biomarkers are only clinically relevant if the uncertainty of the biomarkers is smaller than the variation between timepoints/patients. Unfortunately, this uncertainty is challenging to calculate, as the uncertainty of the underlying hemodynamic data is largely unknown and has several sources that are not additive or normally distributed. This violates normality assumptions of current methods; implying that also biomarkers have an unknown uncertainty. To remedy these problems, we herein present a method, with attached code, for uncertainty calculation of model-derived biomarkers using non-normal data. First, we estimated all sources of uncertainty, both normal and non-normal, in hemodynamic data used to personalize an existing model; the errors in 4D flow MRI-derived stroke volumes were 5-20 % and the blood pressure errors were 0 ± 8 mmHg. Second, we estimated the resulting model-derived biomarker uncertainty for 100 simulated datasets, sampled from the data distributions, by: 1) combining data uncertainties 2) parameter estimation, 3) profile-likelihood. The true biomarker values were found within a 95 % confidence interval in 98 % (median) of the cases. This shows both that our estimated data uncertainty is reasonable, and that we can use profile-likelihood despite the non-normality. Finally, we demonstrated that e.g. ventricular relaxation rate has a smaller uncertainty (∼10 %) than the variation across a clinical cohort (∼40 %), meaning that these biomarkers have clinical potential. Our results take us one step closer to the usage of model-derived biomarkers for cardiovascular patient characterization.}, issn = {0010-4825} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_petersnanna_2025_1, title = {Understanding professionalism through the lens of newly qualified social workers}, author = {Petersén, Anna and Bennich, Maria}, year = {2025}, journal = {European Journal of Social Work}, pages = {1--14}, doi = {10.1080/13691457.2025.2554333}, url = {2009729}, language = {eng}, publisher = {Routledge}, keywords = {newly qualified social workers; professional social work; occupational professionalism; organisational professionalism; discretion; nyutexaminerade socionomer; professionellt socialt arbete; yrkesprofessionalism; organisationsprofessionalism; diskretion}, abstract = {Research shows that the first five years of social work practice are critical for developing professionalism. Understanding professionalism is key to grasping how and why social work is carried out. This paper presents findings from a study exploring Swedish newly qualified social workers’ (NQSWs) perspectives on professionalism, guided by these questions: How do NQSWs define and describe professionalism in social work? How do they perceive opportunities for professional development? What obstacles do they encounter in practicing professional social work? Twenty-two participants were interviewed using a semi-structured guide, and the data were analysed using content analysis. The findings reveal that professionalism is often grounded in core values, such as taking a holistic approach to social problems and upholding clients’ rights. Perceived barriers to professional practice also reflect value-based concerns, for instance, speaking negatively about clients. Views on professional development are shaped by employment context and work tasks, but a consistent theme is the importance of support from experienced colleagues. The results are discussed using the concepts of discretion, autonomy, and occupational versus organisational professionalism, offering a nuanced understanding of how NQSWs perceive and experience professionalism. The findings highlight the need to support NQSWs in balancing organisational demands with core professional values.;Forskning visar att de första fem åren inom socialt arbete är avgörande för utvecklingen av professionalitet. Att förstå professionalitet är nyckeln till att begripa hur och varför socialt arbete utförs. Denna artikel presenterar resultat från en studie som undersöker svenska nyutexaminerade socionomers perspektiv på professionalitet med utgångspunkt i följande frågor: Hur definierar och beskriver de professionalitet inom socialt arbete? Hur uppfattar de möjligheter till professionell utveckling? Vilka utmaningar möter de i utövandet av professionellt socialt arbete? Tjugoen deltagare intervjuades med hjälp av en semistrukturerad intervjuguide och data analyserades med innehållsanalys. Resultaten visar att professionalitet ofta är förankrad i grundläggande värderingar, såsom att ha ett holistiskt synsätt på sociala problem och att upprätthålla klienters rättigheter. Upplevda hinder för professionellt utövande speglar också värderingsbaserade frågor, exempelvis att tala negativt om klienter. Synen på professionell utveckling påverkas av arbetsmiljö och arbetsuppgifter, där ett återkommande tema är vikten av stöd från erfarna kollegor. Resultaten diskuteras med stöd av begreppen diskretion, autonomi samt yrkes-kontra organisatorisk professionalitet, vilket ger en nyanserad förståelse av hur nyutexaminerade socionomer uppfattar och upplever professionalitet. Studien lyfter fram behovet av stöd för att balansera organisatoriska krav med grundläggande professionella värderingar.}, issn = {1369-1457} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lindahlrobert_2025, title = {Understanding the importance of the physical environment in meetings between children and child welfare workers at the social services – A scoping review}, author = {Lindahl, Robert and Pettersson, Cecilia and Nakeva von Mentzer, Cecilia}, year = {2025}, journal = {Children and youth services review}, volume = {169}, doi = {10.1016/j.childyouth.2024.108105}, url = {1924106}, language = {eng}, publisher = {Elsevier}, keywords = {children; child welfare workers; child welfare; physical environment; social services}, abstract = {Research shows that the physical environment, such as meeting rooms and offices, affects prerequisites and outcomes in various forms of human services. This study focuses on the importance of the physical environment in meetings between child welfare workers and children within the Social Services’ activities. The conduction of the study has been inspired by the framework stages for a scoping review described by Arksey and O’Malley (2005). Results show that there is a clear lack of research on this matter. The small number of studies that do exist emphasize that physical and spatial factors clearly affect how contacts and relationships between welfare workers and children are shaped. Included studies show that spatial factors affect children’s participation in assessments, decisions, and the setup of support. The importance of the professionals’ ability to acknowledge the unique needs and desires of each child while at the same time recognising how to benefit from the physical environment where their meetings take place is stressed. Studies show that there is a trend towards contemporary child welfare work shifting from a focus on relational factors to gathering and dealing with information. In general, this field is under-theorized warranting more research with deeper theoretical aspirations.}, issn = {0190-7409}, file = {https://oru.diva-portal.org/smash/get/diva2:1924106/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lintonstevenj_2025, title = {Understanding the individual's transition from acute to chronic disabling pain : Opportunities for improved care}, author = {Linton, Steven J. and Nicholas, Michael K.}, year = {2025}, journal = {Current Opinion in Psychology}, volume = {62}, doi = {10.1016/j.copsyc.2025.101989}, url = {1929690}, language = {eng}, publisher = {Elsevier}, keywords = {acute pain; chronic pain; prevention; risk factors}, abstract = {When acute pain persists, it is said to become chronic after 3 months. Considerable interest has focused on why acute pain appears to transition to chronic pain in some cases, but not all, especially when it becomes disabling. We examine our current understanding of the processes involved in the progression from an acute injury to disabling chronic pain. Rather than viewing this progression as a time dependent transition with specific static risk factors, we consider whether it might be more helpful to understand this evolution in terms of unique individual pathways. While brief self-report screening questionnaires assessing risk factors may enable us to stratify patients into risk levels, they do not provide information on the unique context and factors contributing to the disabling pain for each person. It is proposed that a 2-step process combining screening and individual assessment of those at high risk will enhance the prospect of both early identification and individually relevant interventions before more lasting changes emerge. Rather than being concerned with arbitrary time limits, it is argued that by aiming to understand the unique developmental pathway for those individuals identified as high risk, early, preventive interventions will be both viable and effective. Even so, there are barriers to the implementation of early assessment and matched treatments, and these remain a challenge for future research.}, issn = {2352-250X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_faragoadam_2025, title = {Understanding Wealth-Tax Rates : An Investor-Utility Mapping to Capital-Gains Taxes}, author = {Farago, Adam and Hjalmarsson, Erik and Kiss, Tamás}, year = {2025}, journal = {European Financial Management}, volume = {31}, number = {4}, pages = {1413--1420}, doi = {10.1111/eufm.12541}, url = {1932088}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {capital-gains taxes; horizon effects; risk-averse investors; wealth taxes}, abstract = {Wealth-tax rates are formulated as fractions of a capital stock, rather than fractions of income from capital, which makes them difficult to compare with other (income-based) tax rates. We derive investor-utility comparisons between wealth-tax rates and realized capital-gains tax rates, capturing two crucial features absent in naive comparisons: Risk-aversion and investment horizon, both of which magnify the effect of wealth taxes vis- & agrave;-vis capital-gains taxes. In numerical calibrations, we show that whereas a 1-percent wealth tax might naively be judged equivalent to a 10% capital-gains tax, a more accurate figure for a long-run risk-averse investor is 25%.}, issn = {1354-7798} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_zetterberghedvig_2025_1, title = {Understanding Work Ability in Employees with Pain and Stress-Related Ill-Health : An Explorative Network Analysis of Individual Characteristics and Psychosocial Work Environment}, author = {Zetterberg, Hedvig and Zhao, Xiang and Bergbom, Sofia and Golovchanova, Nadezhda and Flink, Ida and Boersma, Katja}, year = {2025}, journal = {Journal of occupational rehabilitation}, volume = {35}, pages = {333--344}, doi = {10.1007/s10926-024-10200-3}, url = {1857915}, language = {eng}, publisher = {Springer}, keywords = {chronic pain; stress symptoms; work ability; network analysis}, abstract = {Purpose: There is a wide range of individual and work environment factors that influence work ability among workers withpain and stress-related ill-health. The multiple interactions and overlap between these factors are insufficiently understood,and a network approach could mitigate limitations of previous research. This pilot study aimed to explore interactions betweenindividual characteristics and psychosocial work environment and potential links to long-term work ability.Methods: Prospective data from a prevention project was used. Individuals (N = 147) with pain and/or stress-related ill-health(95% women) at public sector workplaces filled out baseline questionnaires about a collection of individual and work environ-ment factors, which were used for constructing undirected networks. The model was run in three subsamples of workplaces.Finally, a separate model was established with work ability at 6-month follow-up as outcome variable. A shortest pathwayanalysis was calculated to identify mediators of work ability.Results: Symptom catastrophizing and perceived stress were the most influential factors in all network models. Symptomcatastrophizing and pain-disability risk were found to mediate the relation between perceived stress and long-term workability. Further, demand-control-support factors were interrelated, and patterns of interaction differed between differenttypes of workplaces.Conclusion: The findings support the importance of individual factors, specifically symptom catastrophizing in an individual’scoping with pain or stress-problems and its influence on long-term work ability. Catastrophizing might play a role in stress-related disorders which should be further investigated. Individual and work environment factors interact and vary acrosscontext, which needs to be taken into consideration to prevent pain and stress-related ill-health at work.}, issn = {1053-0487} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_barowthomas_2025_1, title = {Undervisning av ”de andra” i historiskt perspektiv}, author = {Barow, Thomas}, year = {2025}, pages = {169--196}, url = {1954448}, language = {swe}, publisher = {Studentlitteratur AB}, keywords = {intellectual disability; special school; feeble-minded; teaching; intellektuell funktionsnedsättning; anpassad grundskola; särskola; sinnesslöskol; sinnesslö; undervisning} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_micheliandrea_2025, title = {Unified Planning : Modeling, manipulating and solving AI planning problems in Python}, author = {Micheli, Andrea and Bit-Monnot, Arthur and Röger, Gabriele and Scala, Enrico and Valentini, Alessandro and Framba, Luca and Rovetta, Alberto and Trapasso, Alessandro and Bonassi, Luigi and Gerevini, Alfonso Emilio and Iocchi, Luca and Ingrand, Felix and Köckemann, Uwe and Patrizi, Fabio and Saetti, Alessandro and Serina, Ivan and Stock, Sebastian}, year = {2025}, journal = {SoftwareX}, volume = {29}, doi = {10.1016/j.softx.2024.102012}, url = {1929586}, language = {eng}, publisher = {Elsevier}, keywords = {automated planning and scheduling; python library; interoperability}, abstract = {Automated planning is a branch of artificial intelligence aiming at finding a course of action that achieves specified goals, given a description of the initial state of a system and a model of possible actions. There are plenty of planning approaches working under different assumptions and with different features (e.g. classical, temporal, and numeric planning). When automated planning is used in practice, however, the set of required features is often initially unclear. The Unified Planning (UP) library addresses this issue by providing a featurerich Python API for modeling automated planning problems, which are solved seamlessly by planning engines that specify the set of features they support. Once a problem is modeled, UP can automatically find engines that can solve it, based on the features used in the model. This greatly reduces the commitment to specific planning approaches and bridges the gap between planning technology and its users.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_islammsirajul_2025, title = {Unlocking the Cashless Shift : Retailers’ Adoption of Digital Payment Systems in Emerging Markets}, author = {Islam, M. Sirajul and Ferrer, Mario A.}, year = {2025}, journal = {Journal of Theoretical and Applied Electronic Commerce Research}, volume = {20}, number = {4}, pages = {359--395}, doi = {10.3390/jtaer20040359}, url = {2023170}, language = {eng}, publisher = {MDPI}, keywords = {digital payment systems; retailers; fintech adoption; technology–organization– environment (toe) framework; institutional trust; digital transformation; emerging markets; saudi arabia}, abstract = {Retailers play a pivotal role in advancing digital commerce in emerging markets, yet their adoption of digital payment systems remains inconsistent. Drawing on the Technology–Organization–Environment (TOE) framework, this study examines how technologica lreadiness, organizational capability, and environmental influences shape retailers’ adoption behavior in Saudi Arabia. Survey data from retailers in Riyadh indicates that transaction speed, convenience, and perceived usefulness function as key enablers, while transaction fees, limited digital skills, and security concerns act as barriers. Although institutional trust and supportive government initiatives encourage adoption, many retailers remain unaware of formal compliance expectations, illustrating a pattern of compliance without awareness. To account for this dynamic, the TOE framework is extended by incorporating regulatory literacy and institutional trust as contextual dimensions. The study therefore offers theoretical refinement to TOE in policy-driven adoption settings and provides practical implications for improving merchant training, usability support, and regulatory communication to better sustain digital payment usage in emerging digital commerce ecosystems.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rasmussenjoel_2025, title = {Unpacking qualitative data in organizational trust research : An application to community appraisal of COVID-19 management in Scandinavia}, author = {Rasmussen, Joel}, year = {2025}, journal = {Qualitative Research in Organizations and Management}, volume = {20}, number = {5}, pages = {21--40}, doi = {10.1108/qrom-12-2023-2642}, url = {1965816}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {methodology; qualitative research; discourse; organizational trust; appraisal analysis; covid-19 management}, abstract = {Purpose: Organizational trust is often professed to be communication-based, yet organizational research rarely provides methodological frameworks exploring how orientations to trust are articulated in communication. This paper therefore aims to help unpack how positions on trust are articulated in qualitative, conversational data in away that can be useful for future qualitative research into organizational trust.Design/methodology/approach: The study contributes methodologically by introducing an untapped resource, appraisal analysis, and applying it to focus groups evaluating the pandemic response in Scandinavia.Findings: The analysis suggests that the emphasis of previous research on rational justifications of trust, commonly via assessments of ability, integrity and benevolence, leaves unexplored stances on trust that are taken more straightforwardly with potential effects on power relations. The study draws attention to suchalternative ways of realizing trust/distrust, with the concepts of simple-assertive evaluation and prescriptive evaluation, which still empower (or oppose) organizations and leaders. In addition, the study disentangles some of the “messiness” of qualitative data by demonstrating how stances on organizational trust involve activity-, agent-, and results-centered evaluations, as well as mixed evaluations.Originality/value: Through the suggested analytical framework, common challenges with qualitative data, involving ambiguities regarding power, agency and overall dilemma-ridden situations, can be dealt with better. It thereby offers methodological fine-tuning that enables a more exhaustive analysis of trust as acommunication-based process. }, issn = {1746-5648}, file = {https://oru.diva-portal.org/smash/get/diva2:1965816/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jothimaniganesan_2025, title = {Unraveling the mechanism of microRNA-134 in colon cancer progression : Targeting KRAS and PIK3CA for cell cycle control and histone deacetylase regulation}, author = {Jothimani, Ganesan and Das, Diptimayee and Pathak, Surajit and Malayaperumal, Sarubala and Zhang, Hong and Sun, Xiao-Feng and Banerjee, Antara}, year = {2025}, journal = {Experimental Cell Research}, volume = {444}, number = {2}, doi = {10.1016/j.yexcr.2024.114385}, url = {1925835}, language = {eng}, publisher = {Academic Press}, keywords = {colon cancer; histone deacetylases; kras; pi3k; mir-134-5p; mirna-mrna docking}, abstract = {Colon cancer is the leading cause of cancer-related deaths worldwide. MicroRNAs (miRNAs) are key regulators of gene expression, often dysregulated in colon cancer. This study aims to elucidate the therapeutic role of miR-134-5p as a tumor suppressor miRNA in colon cancer cells. We analyzed miRNA expression profiles in primary and metastatic colon cancer cells. The clinical significance of miR-134-5p was evaluated using the TCGA database. Bioinformatics tools (HADDOCK) predicted miRNA-mRNA interactions and the molecular docking of miRNA-mRNA-AGO2 complexes. Luciferase reporter assays, cell proliferation, immunofluorescence, colony forming unit assays, and qRT-PCR analysis assessed miR-134-5p effects on KRAS, PIK3CA, and downstream signaling pathways in primary and metastatic colon cancer cells. miR-134-5p was downregulated in colon cancer cells. Bioinformatics analysis suggested KRAS, PIK3CA, EGFR, and HDAC5 as potential targets. HADDOCK analysis revealed strong binding affinity and structural stability between KRAS, PIK3CA, miR-134-5p, and AGO2. Gene-reporter assays confirmed miR-134-5p-mediated degradation of KRAS and PIK3CA. miR-134-5p transfection reduced KRAS and PI3K protein levels, suppressed EGFR/RTK signaling and its downstream targets, and inhibited HDAC expression, ultimately reducing colon cancer cell proliferation. The results of this study confirm that miR-134-5p acts as a potential tumor suppressor miRNA in colon cancer cells by inhibiting KRAS and PI3K expression through AGO2-mediated gene silencing. It deregulates downstream EGFR signaling and HDACs, thereby reducing colon cancer cell proliferation. These findings highlight miR-134-5p as a promising therapeutic target for miRNA-mediated anticancer therapy.}, issn = {0014-4827} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_marisilvia_2025, title = {Unraveling the Relationship Between Beliefs in Traditional Gender Roles and Voting Participation : A Cross-National Perspective}, author = {Mari, Silvia and Vezzoli, Michela and Goh, Jin X. and Khan, Sammyh S. and Liu, James H. and Schumann, Sandy}, year = {2025}, journal = {Gender Issues}, volume = {43}, number = {1}, doi = {10.1007/s12147-025-09392-6}, url = {2013576}, language = {eng}, publisher = {Springer}, keywords = {traditional gender roles; gender inequality; voting; cross-country research; multi-group factor analysis alignment}, abstract = {Participation in elections is essential for the health of democracies. Regardless of gender, individuals may hold traditional beliefs about women's roles in society that hinder their engagements in areas that challenge gender stereotypes, such as political participation. In this study, we examined how gender and beliefs about gender roles influence voting participation, while accounting for various ideological and demographic factors. We also explored how structural gender inequality, as measured by the country-level Gender Inequality Index, is reflected in voting at the individual level. Data were collected in a cross-country study (N = 19,297 participants, 51.2% women, mean age = 41.3, SD = 14.76) from 18 countries. We employed an innovative method, Multi-Group Factor Analysis Alignment, to address cross-country measurement invariance of the Traditional Gender Roles scale-a key construct in this study. Results from multi-level modeling revealed significant main effects of gender and beliefs about traditional gender roles, but no significant interaction between them. Citizens who endorse traditional gender roles were less likely to vote, regardless of their gender. This effect was more pronounced in societies with low to moderate levels of structural gender inequality. In contrast, in countries with pervasive gender inequality, voting was not associated with individual beliefs about gender roles. These findings highlight the importance for policymakers to address the detrimental effects of structural gender inequality and traditional gender roles in society, that can hinder citizens participation in voting.}, issn = {1098-092X} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_depascaleroberto_2025, title = {Unsupervised machine learning identifies distinct SLE patient endotypes with differential response to belimumab}, author = {Depascale, Roberto and Da Mutten, Raffaele and Lindblom, Julius and Cetrez, Nursen and Palazzo, Leonardo and Iaccarino, Luca and Doria, Andrea and Nikolopoulos, Dionysis and Gatto, Mariele and Parodis, Ioannis}, year = {2025}, journal = {Rheumatology}, volume = {64}, number = {8}, doi = {10.1093/rheumatology/keaf215}, url = {1954444}, language = {eng}, publisher = {Oxford University Press}, keywords = {b cells; belimumab; machine learning; systemic lupus erythematosus}, abstract = {OBJECTIVE: To determine systemic lupus erythematosus (SLE) endotypes according to B cell immunophenotyping and serological profile and assess endotypes' response to belimumab.METHODS: We analysed data from 796 patients with SLE from the phase III trial BLISS-SC. Unsupervised machine learning employing factor analysis of mixed data (FAMD) and subsequent clustering determined endotypes based on B cell immunophenotyping and serological profiles. Cox regression was used to assess belimumab efficacy on inducing lupus low disease activity state (LLDAS) and Definitions of Remission in SLE (DORIS) remission within clusters.RESULTS: Three endotypes were determined. Compared to each other, cluster 1 (n = 191) displayed higher proportions of CD19+CD24b+CD27+ regulatory B cells [mean ± standard deviation (SD): 35.9%±12.6%], CD19+CD20+CD27+ bulk memory B cells (32.2%±9.9%), CD19+CD20+CD69+ activated B cells (0.2%±0.3%), CD19+CD20-CD138+ long-lived plasma cells (0.7%±1.0%), and CD19+CD38b+CD27b+ SLE-associated plasma cells (6.6%±7.0%). Cluster 2 (n = 366) displayed higher proportions of CD19+CD24bbrightCD38bbrightCD27- transitional B cells (6.3%±9.0%) and CD19+CD20+CD27- naïve B cells (85.4%±7.2%), and lower proportions of CD19+CD20-CD138+ peripheral long-lived plasma cells (0.2%±0.3%) and CD19+CD38b+CD27b+ SLE-associated plasma cells (1.6%±2.0%). Cluster 3 (n = 239) displayed a higher proportion of CD19+CD20+CD138+ short-lived plasma cells (0.1%±0.1%) and higher serological activity, being enriched in anti-double stranded(ds)DNA, anti-extractable nuclear antigens (ENA), antiphospholipid antibodies, and hypocomplementemia. Use of belimumab was superior to placebo in inducing sustained LLDAS (HR: 2.22; 95% CI: 1.18-4.17; p = 0.014) and DORIS remission (HR: 3.45; 95% CI: 1.2-9.94; p = 0.022) in cluster 2.CONCLUSION: Three distinct SLE endotypes were identified based on B cell immunophenotyping and serological profiles, showing differential benefit from belimumab therapy.}, issn = {1462-0324} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_hlmanchristoffer_2025_4, title = {(Un)sustainable forests : Educational narratives of forests and forestry in Sweden and Finland 1972-2020s}, author = {Åhlman, Christoffer and Kortekangas, Otso}, year = {2025}, url = {1998254}, language = {eng}, abstract = {In our joint project, we investigate what different interpretations and meanings (e.g., economic, ecological, cultural, recreational) school textbooks have presented about forests in Sweden and Finland (1972–today). Our ESEH paper is inspired by the conference themes “storytelling in terms of the historical and present experience of living with climate uncertainty, biodiversity loss, or rapid landscape change”, and “didactics and themes for teaching climate history with practical examples of approaches and pedagogics”. We will especially look at how Swedish and Finnish forests and forestry are portrayed in the textbooks studied and what meanings of forests are highlighted. We will use a sample of textbooks from the subjects of biology, geography, social studies (samhällskunskap/yhteiskuntaoppi) and investigate how the meanings of forests as ecology, biodiversity and more recently carbon sink intertwine, compete and conflict with stubborn ideas of forests as resources of national economy. We will also investigate the relationship between Nordic forests and forestry practices and the ideas of forest destruction in the Global South and pose the critical question whether our educational systems are up to the task of teaching our young citizens about past, current and future cases of climate uncertainty, biodiversity loss and landscape change.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_castroalvesvictor_2025_1, title = {Upcycling Agro-Industrial Biomass into Bioactive Oligosaccharides for the Circular Bioeconomy : Beyond the Prebiotic Effects with a Focus on Receptor Interactions}, author = {Castro Alves, Victor and Prado, Samira}, year = {2025}, journal = {ACS Food Science & Technology}, volume = {5}, number = {11}, pages = {4078--4092}, doi = {10.1021/acsfoodscitech.5c00914}, url = {2016238}, language = {eng}, publisher = {American Chemical Society (ACS)}, keywords = {dietary fiber; functional ingredients; functionalfoods; host-glycan interactions; food legislation}, abstract = {Oligosaccharides represent an important class of bioactive compounds with diverse structure-dependent functionalities. While traditionally investigated for prebiotic effects on gut microbiota, increasing evidence shows that they can also interact directly with intestinal and immune cell receptors (e.g., pattern recognition receptors, C-type lectin receptors, G-protein coupled receptors, and scavenger receptors), influencing inflammation, mucosal immunity, and epithelial barrier function. In a circular bioeconomy context, oligosaccharides offer an underexplored sustainable route for upcycling agro-industrial and forestry biomass by converting polysaccharides into structurally tailored products. This review synthesizes current knowledge on the direct effects of plant-derived oligosaccharides on host receptors and describes enzymatic and green chemistry-based methods for their production and extraction. We propose a new roadmap for oligosaccharide upcycling using assessments for their biological effects, characterization, standardization, and alignment with regulatory aspects. This enables translating receptor-active oligosaccharides from biomass utilization into innovative solutions for precision nutrition and sustainable functional food development.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ullstenalexandra_2025, title = {Updated Guidelines Stress the Need for Transparent Reporting of Music-Based Interventions in Clinical Research}, author = {Ullsten, Alexandra}, year = {2025}, journal = {Acta Paediatrica}, doi = {10.1111/apa.70394}, url = {2023107}, language = {eng}, publisher = {John Wiley & Sons}, issn = {0803-5253} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_30, title = {Uppdaterad rättslig vägledning : kostnadsersättningar och SINK}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031736}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Skatteverket har uppdaterat sin rättsliga vägledning med exempel på hur kostnadsersättningar för resor för personer som beskattas enligt lagen om särskild inkomstskatt för utomlands bosatta (1991:586), SINK. Eleonor Kristoffersson, professor i skatterätt, diskuterar rättsläget.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_mijaljeviclidija_2025, title = {Urinary and sexual dysfunction in patients with rectal cancer following a watch and wait protocol - results from the Swedish national WoW study}, author = {Mijaljevic, Lidija and Azhar, Najia and Chabok, Abbas and Folkesson, Joakim and Gerdin, Anders and Grönkvist, Rode and Hermus, Linda and Larsson, Charlotta and Martling, Anna and Matthiessen, Peter and Nilsson, Per and Rydbeck, Daniel and Angenete, Eva}, year = {2025}, journal = {British Journal of Surgery}, volume = {112}, number = {Suppl. 11}, pages = {xi24--xi24}, doi = {10.1093/bjs/znaf149.085}, url = {1991919}, language = {eng}, publisher = {Oxford University Press}, abstract = {Introduction: Treatment for rectal cancer is associated with urinary and sexual dysfunction. Few studies describe urinary and sexual function after neoadjuvant (chemo)radiotherapy and a watch and wait (WoW) approach. This study aimed to evaluate the prevalence and change over time in patient-reported urinary and sexual dysfunction in patients within the Swedish watch and wait study.Method: The Swedish Watch and Wait (WoW) study is a multicenter prospective cohort study including patients with clinical complete response (cCR) after (chemo)radiotherapy for rectal cancer. A total of 211 patients with cCR (stage I-III rectal cancer) were included between January 2017 and February 2023. Questionnaires were collected at baseline, 6 months, 1 year, and 2 years post-treatment.Result: Questionnaire data were available for 173 patients at baseline and 136 at two years. The median age was 66 years (60% male). Neoadjuvant treatment was given as short-course radiotherapy (SCRT) (27.5%), SCRT combined with chemotherapy (66.5%), long-course chemoradiotherapy (4.9%) and other treatments (1.1%).Urinary incontinence during daytime increased from 9,2 % at baseline to 14,7% two years after treatment. Erectile dysfunction was stable: 24,0 % at baseline and 23,5 % at two years follow-up. In women, sexual function including arousal, lubrication and orgasm decreased during follow-up.Discussion: Urinary and sexual dysfunction is seen in patients treated with neoadjuvant therapy without subsequent surgery. Urinary incontinence slightly increased during follow-up. Female sexual function decreased, whereas erectile dysfunction remained stable during follow-up. The results are encouraging but also indicate that dysfunction is present, albeit to a lesser extent than if surgery is part of the treatment.}, issn = {0007-1323} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sherinan_2025, title = {URINE LEVELS OF COMPLEMENT PROTEINS DIFFERENTIATE LUPUS NEPHRITIS FROM NON-RENAL SYSTEMIC LUPUS ERYTHEMATOSUS}, author = {Sherina, N. and Tonoian, R. and Nikopoulos, D. and Tamirou, F. and Houssiau, F. and Parodis, Ioannis}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {84}, number = {Suppl. 1}, pages = {2176--2177}, doi = {10.1016/j.ard.2025.06.1809}, url = {1988624}, language = {eng}, publisher = {Elsevier}, keywords = {renal system; biomarkers}, abstract = {Background: Complement activation is known to play a dual role in the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis (LN). It is protective through the effective clearance of immune complexes and cellular waste but becomes damaging when uncontrolled complement activation promotes kidney injury. Although aberrant complement activation and regulation is involved in the pathogenesis of SLE, understanding of its role in the activity of LN remains limited.Objectives:To evaluate levels of circulating and excreted complement activation and regulatory markers in relation to SLE and LN activity, and in relation to response to treatment for active LN.Methods: We analysed activation profiles of the classical and alternative complement pathway, as well as concentrations of complement activation-inhibitory and regulatory proteins in matched serum and urine samples from 20 SLE patients without LN (10 with active SLE and 10 in remission) from Karolinska University Hospital in Stockholm, Sweden, 21 SLE patients with active biopsy-proven LN from Cliniques universitaires Saint-Luc in Brussels, Belgium, and 15 healthy controls (HC) from Karolinska University Hospital. LN samples were analysed at two time points, i.e., before commencement of immunosuppressive therapy for active LN (T0) and after one year of therapy (T1), mainly comprising glucocorticoids and either mycophenolate mofetil or low-dose intravenous cyclophosphamide. Concentrations of complement proteins Ba, Bb, C3a, C4a, C5a, sC5b-9, factor H, and factor I were assessed using Quidel MicroVue Multiplex Complement Array. The Mann–Whitney U test was employed to compare levels of complement proteins between groups.Results: Serum levels of complement fragments Ba, Bb, C3a, C5a, factor I, factor H did not differ significantly between patients with SLE, with or without active LN, and HC. However, serum levels of C4a and sC5b-9 were significantly higher in patients with LN compared to SLE patients without LN (Figure 1A, median 1641 vs 923 ng/mL; p=0.0003 and 2414 vs 1625 ng/mL; p=0.019, respectively), whereas serum Bb, C3a, factor I, and factor H levels were significantly higher in SLE patients without LN (median 3.93 vs 2.53 μg/mL; p=0.0005; 1863 vs 1322 ng/mL; p=0.003; 42.7 vs 22.9 μg/mL; p=0.0001; 469.5 vs 324 μg/mL; p=0.004, respectively). In LN patients, serum levels of Ba, Bb, C5a, cC5b-9, and factor I were significant reduced after one year of immunosuppressive therapy (1580.3 vs 968.7 ng/mL; p=0.0006; 3.51 vs 2.48 μg/mL; p=0.01; 31.8 vs 24.2 ng/mL; p=0.04; 3164.7 vs 2154 ng/mL; p=0.009; 29 vs 20.6 μg/mL; p=0.009, respectively). Analysis of urine samples revealed significantly higher levels of all measured complement proteins in LN patients both compared to SLE without LN and to HC (Figure 1B; p<0.0001 for all comparisons). Consistent with findings in serum, urine levels of Ba and C5a were significantly reduced in LN patients after one year of therapy (52.1 vs 22.5 ng/mL; p=0.0002; 1.92 vs 0.31 ng/mL; p=0.0001, respectively). Complement activation did not differ in patients with active SLE compared to SLE patients in remission; none of the evaluated complement proteins showed significant differences between the two groups, in serum or in urine.Conclusion: Our data indicate that elevated urine levels of complement activation and regulatory markers are characteristic of SLE patients with LN. Notably, urine levels of C5a and Ba were significantly reduced following therapy, suggesting their potential as biomarkers of renal activity.}, issn = {0003-4967} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hiruyhiwot_2025, title = {US Food and Drug Administration, Centers for Disease Control and Prevention, and National Institutes of Health Co-Sponsored Public Workshop Summary-Development Considerations of Antimicrobial Drugs for the Treatment of Gonorrhea}, author = {Hiruy, Hiwot and Bala, Shukal and Byrne, James M. and Roche, Kerian Grande and Jang, Seong H. and Kim, Peter and Nambiar, Sumathi and Rubin, Dan and Yasinskaya, Yuliya and Bachmann, Laura H. and Bernstein, Kyle and Botgros, Radu and Cammarata, Sue and Chaves, Ricardo L. and Deal, Carolyn D. and Drusano, George L. and Duffy, Erin M. and Eakin, Ann E. and Gelone, Steve and Hiltke, Thomas and Hook Iii, Edward W. and Jerse, Ann E. and McNeil, Candice J. and Newman, Lori and O'Brien, Seamus and Perry, Caroline and Reno, Hilary E. L. and Romaguera, Raul A. and Sato, Junko and Unemo, Magnus and Wi, Teodora E. C. and Workowski, Kimberly and O'May, Graeme A. and Shukla, Sunita J. and Farley, John J.}, year = {2025}, journal = {Clinical Infectious Diseases}, volume = {81}, number = {6}, pages = {1201--1208}, doi = {10.1093/cid/ciae386}, url = {1891141}, language = {eng}, publisher = {University of Chicago Press}, keywords = {antimicrobial drugs; antimicrobial resistance; drug development; gonorrhea; unmet need}, abstract = {There is an unmet need for developing drugs for the treatment of gonorrhea, due to rapidly evolving resistance of Neisseria gonorrhoeae against antimicrobial drugs used for empiric therapy, an increase in globally reported multidrug resistant cases, and the limited available therapeutic options. Furthermore, few drugs are under development. Development of antimicrobials is hampered by challenges in clinical trial design, limitations of available diagnostics, changes in and varying standards of care, lack of robust animal models, and clinically relevant pharmacodynamic targets. On April 23, 2021, the U.S. Food and Drug Administration; Centers for Disease Control and Prevention; and National Institute of Allergy and Infectious Diseases, National Institutes of Health co-sponsored a workshop with stakeholders from academia, industry, and regulatory agencies to discuss the challenges and strategies, including potential collaborations and incentives, to facilitate the development of drugs for the treatment of gonorrhea. This article provides a summary of the workshop.}, issn = {1058-4838} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_danckwardtpetter_2025, title = {”USA:s expansionism och hotet mot omvärlden – vad kan folkrätten säga?”}, author = {Danckwardt, Petter}, year = {2025}, journal = {Dagens juridik}, number = {9 januari}, url = {1928754}, language = {swe}, publisher = {Blendow Publishing AB}, keywords = {usa; folkrätt; expansionism; intervention} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_stahrenanna_2025, title = {Use of green liquor dregs for reclamation of historical mining waste : suitable properties and results from a full-scale reclamation in 2017}, author = {Stahre, Nanna and Sartz, Lotta and Sädbom, S. and Bäckström, Mattias}, year = {2025}, doi = {10.36487/ACG_repo/2515_61}, url = {2028809}, language = {eng}, publisher = {Australian Centre for Geomechanics}, keywords = {acid rock drainage; alkaline waste products; waste rock}, abstract = {Green liquor dreg (GLD) is a calcite dominated alkaline byproduct from the pulp and paper industry with high buffering capacity and thixotropic properties, making it suitable for treatment of acidic mining waste. In a comprehensive four-year study, GLD from 16 Swedish mills was characterised through multiple sampling campaigns, analysing elemental composition, buffering capacity, sequential leaching, and interactions with acid rock drainage. This dataset is now a robust foundation for understanding the variability of GLD between mills, offering key insights into which parameters are most critical for different mining waste applications.Several small and medium sized tests have been performed, with good results, to determine the suitability and possible drawbacks when mixing GLD and acid mining waste. As a final confirmation of the technique approximately 4,500 tonnes of acid mining waste at Gladhammar, Sweden (pH 3.8, 96 mg/L copper and 21 mg/L cobalt) was slurry injected with 100 tonnes of GLD in 2017.During injection, pH in the drainage from the area increased from 3.5 to around 10 due to excess GLD being washed out. One to two months after injection, pH was around 7.5 and concentrations of copper and cobalt was 38 and 4.9 mg/L, respectively. During 2024, pH was 8 and concentrations of copper and cobalt were 1.1 and 0.95 mg/l, respectively.The challenge at Gladhammar was to reduce metal loads while allowing the waste rock piles to be accessible for mineral hunters and geoscientific studies in the future. With alkaline injections, areas with cultural, historical and geological values can be treated with low visual impact.The full-scale reclamation at Gladhammar confirms that GLD can be used for reclamation of historical mining waste as pH increases and trace element concentrations decrease. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ljungstrmbrittmarie_2025, title = {Use of qualitative comparative analysis (QCA) in an explanatory sequential mixed methods design to explore combinations of family factors that could have an impact on the outcome of a parent training program}, author = {Ljungström, Britt-Marie and Denk, Thomas and Sarenmalm, Elisabeth Kenne and Axberg, Ulf}, year = {2025}, journal = {Children and youth services review}, volume = {170}, doi = {10.1016/j.childyouth.2025.108120}, url = {1942165}, language = {eng}, publisher = {Elsevier}, abstract = {Parent training programs (PT) have consistently been shown to be effective for families with children displaying disruptive behavior problems (DBP). However, not all families seem to benefit equally from these programs and the effects are small to moderate. Several studies have examined single factors that might explain variations in outcomes with inconclusive results, and there seems to be a need for a deeper understanding of complex pattern of factors. This generally requires large sample sizes which might be difficult to obtain. Qualitative comparative analysis (QCA) is a method, rarely used in mental health research, that originally was developed for use in research with small and medium sample sizes for understanding and exploring complex real-world situations. The aim of this study was to generate a deeper understanding about combinations of factors that may have an impact on the outcome of PT programs. In addition, we also wanted to introduce QCA in research on mental health interventions and to explore the usefulness of QCA as a bridge between the quantitative and qualitative phases in an explanatory sequential mixed methods study. There were three different pathways, with unique combinations, showing different ways to maintain DBPs after PT and four different combinations of conditions associated with a positive outcome after PT. We also found that QCA was well suited for this type of analysis and that it might be a useful method to generate specific hypothesis that can be tested in future research.}, issn = {0190-7409} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_taygarafraselma_2025, title = {User-Driven Development of a Digital Behavioral Intervention for Chronic Pain : Multimethod Multiphase Study}, author = {Taygar, Afra Selma and Bartels, Sara Laureen and de la Vega, Rocío and Flink, Ida and Engman, Linnea and Petersson, Suzanne and Johnsson, Sophie I. and Boersma, Katja and McCracken, Lance M. and Wicksell, Rikard K.}, year = {2025}, journal = {JMIR Formative Research}, volume = {9}, doi = {10.2196/74064}, url = {1982858}, language = {eng}, publisher = {JMIR Publications}, keywords = {behavioral intervention; chronic pain; development; digital therapeutics; end-user involvement}, abstract = {BACKGROUND: Recent research shows that chronic pain affects 27% of the adult population. For many, pain significantly impairs quality of life and everyday functioning. Behavioral interventions have shown utility, but access remains limited. Digital health solutions can increase reach, but there is a need for user-friendly, feasible, and evidence-based digital interventions.OBJECTIVE: This study aimed to clarify how a digital behavioral intervention for people with chronic pain can be developed through a user-centered approach to address the needs and preferences of the target population.METHODS: This study used a multimethod approach involving end users, namely, patients with chronic pain and therapists, to develop prototypes for a digital behavioral intervention across 3 phases. In the preparation phase (phase 0), fictional patient personas (n=3) were created to represent the diversity of the target population while emphasizing transdiagnostic features across people with chronic pain. In the design phase (phase 1), qualitative data from focus groups with patients (n=5; aged 37-51 years; 4/5, 80% women; 2/5, 40% diagnosed with Ehlers-Danlos syndrome; 3/5, 60% either undiagnosed or uncertain about their diagnosis) and therapists (n=12 licensed psychologists; aged 29-64 years; 9/12, 75% women) were collected to explore end-user preferences for the intervention design and content. In the testing phase (phase 2), the initial full prototype of the digital intervention was piloted with patients (n=11; aged 36-58 years; 9/11, 82% women; with diverse diagnoses, including migraine, arthritis, fibromyalgia, complex regional pain syndrome, hypermobile Ehlers-Danlos syndrome, herniated disc, chronic fatigue syndrome, and 1/11, 9% cases of undiagnosed pain) and therapists (n=3 licensed psychologists; aged 36-58 y; 3/3, 100% women). The Consolidated Framework for Implementation Research was used to structure analyses of end-user feedback.RESULTS: On the basis of end-user input, a 6-week digital behavioral intervention for chronic pain was created. Focus groups highlighted the importance of accessibility and adaptability of the digital intervention, emphasizing the need for tailored content, flexibility (eg, contact with the therapist via asynchronous messaging, telephone, or video calls), and user-friendly design (eg, easy navigation between modules, short microsessions, and visualizations). Average weekly ratings (scale from 1=not at all to 7=very much) by patients during pilot-testing indicated that the intervention was helpful (mean range 4.27-5.45, SD range 1.20-2.20), enjoyable (mean range 3.81-4.81, SD range 1.12-2.08), and understandable (mean range 4.45-6, SD range 1.30-1.86), suggesting initial acceptability and usability of the intervention.CONCLUSIONS: The results illustrated the utility of the patient personas when preparing, of the focus groups when designing, and of the end-user feedback when testing this new digital intervention for people with chronic pain. The findings indicated that the intervention is promising while also providing relevant end-user suggestions (eg, video content, text-to-speech function, and add-on modules) to guide further improvements.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_roussefrancois_2025, title = {Using Random-SVD to Improve Exact Quantum Dynamics Simulations}, author = {Rousse, Francois and Fasi, Massimiliano and Dmytryshyn, Andrii and Gulliksson, Mårten and Ögren, Magnus}, year = {2025}, pages = {23--23}, url = {1991805}, language = {eng}, abstract = {The unmanageable amount of encoded information in a many-body particles system makes calculations of its dynamic a challenge. Because of the many degrees of correlation between the particle states, the complexity of the many-body state increases exponentially with the number of particles and their available states. A method that can manage this challenge of complexity is the Gaussian Phase-Space Representation (GPSR) [1]. In GPSR, the wave-function is mapped to a density probability of one-particle density matrices, and the time-dependent Schrödingerequation to a Fokker-Planck equation (FPE). The FPE has to be solved with stochastic differential equations but unfortunately, using stochastic processes induces a maximum simulation time, because some trajectories will end up diverging, which nullifies the validity of averages and prevents us from recovering quantum observables. However, there is a freedom in the decomposition of the diffusion matrix D into the noise matrix B, with D = BBT, and we can extend the maximum simulation time by choosing a ‘better’ noise matrix [2, 3]. We present here the results of GPSR with a noise-matrix computed with a random-SVD [4], which doubles the maximum simulation time while keeping the computational cost reasonable. Understanding why this decomposition works so well might help us finding even better decompositions. References[1] Corney, J. F. and Drummond, P. D. Gaussian operator bases for correlated fermions. Journal of Physics A: Mathematical and General, Volume 39, 269 (2005).[2] Ögren, M., Kheruntsyan, K. V. and Corney, Joel F. Stochastic simulations of fermionic dynamics with phase-space representations. Computer Physics Communications, Volume 182, 1999 (2011).[3] Rousse, F., Fasi, M., Dmytryshyn, A., Gulliksson, M. and Ögren, M. Simulations of quantum dynamics with fermionic phase-space representations using numerical matrix factorizations as stochastic gauges. Journal of Physics A: Mathematical and Theoretical, Volume 57, 015303, (2024).[4] Halko, N., Martinsson, P. G. and Tropp, J. A. Finding structure with randomness: Probabilistic algorithms for constructing approximate matrix decompositions. SIAM review,Volume 53, 217, (2011).} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sernboelisabet_2025_1, title = {Using theory - To predict outcomes, describe, analyse or interpret? A framework for analysing the use of theories}, author = {Sernbo, Elisabet and Svärd, Veronica and Matérne, Marie}, year = {2025}, journal = {Qualitative Social Work}, doi = {10.1177/14733250251387586}, url = {2007791}, language = {eng}, publisher = {Sage Publications}, keywords = {theory; knowledge; writing; theorising}, abstract = {This article directs attention to theory in academic writing. The empirical material analysed consists of 52 Swedish doctoral dissertations on social work in healthcare, published between 2008 and 2019. The aim of the study is to describe and suggest a framework for analysing the use of theories in research work. The results suggest that the field is characterised by an intersection of sciences, mirrored by two overarching ways of understanding theory. One approach, less frequently drawn upon, is analysed as influenced by the health sciences, understanding theory as a means of predicting outcomes by using different variables, without defining them within a broader theoretical framework. Theorising is here analysed as the enabling of predicting outcomes, by generalisations. The more common approach to theory is analysed as influenced by the social sciences, understanding theory as a way of understanding society and social relations, explicitly defining and referencing the concepts used. Within this second approach, theorising is done differently and, drawing on Wolcott<acute accent>s descriptions of ways of doing analysis in ethnography, we propose three ways of understanding this theorising, conceptualised as Description, Analyses and Interpretation. In the article we outline how different understandings of theory and theorising allow for different kinds of knowledge to be gained. The framework presented can be useful for students and researchers when planning research and writing academic texts, clarifying different ways of understanding theory and the potential use of variables and theoretical concepts: from aim, to analysis and implications.}, issn = {1473-3250} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sundbergfrida_2025, title = {Using Time in Tight Glucose Range as a Health-Promoting Strategy in Preschoolers With Type 1 Diabetes}, author = {Sundberg, Frida and Smart, Carmel E. and Samuelsson, John and Åkesson, Karin and Krogvold, Lars}, year = {2025}, journal = {Diabetes Care}, volume = {48}, number = {1}, pages = {6--14}, doi = {10.2337/dci24-0058}, url = {1914045}, language = {eng}, publisher = {American Diabetes Association}, abstract = {Children who develop diabetes in their first years of life risk being exposed to many decades of hyperglycemia, hence having a high risk of early complications and premature death. An additional age-dependent risk is that dysglycemia, especially hyperglycemia, negatively affects the developing brain. In evaluating the outcome of insulin treatment at an individual and group level, cutoff thresholds for glucose values are needed. Time in tight range (TITR) was defined as a measurement of time spent in a state of normoglycemia. The International Society of Pediatric and Adolescent Diabetes recommended that for preschoolers with type 1 diabetes (T1D), either >70% of time with glucose in range 70-180 mg/dL (3.9-10 mmol/L) or >50% of time in a tighter range 70-140 mg/dL (TITR) can be used as continuous glucose monitoring targets. In Sweden, over the past two decades, pediatric diabetes teams set glycemic targets to 70-140 mg/dL (3.9-7.8 mmol/L). Swedish registry data show that >50% of children <7 years old have >50% TITR. The purpose of this review is to share and discuss international knowledge and experiences of working with TITR as a health-promoting strategy in preschoolers with T1D on a structural and individual level. We conclude that as insulin treatment improves, a reasonable goal is to strive for as much time in a state of normoglycemia as possible, and this can easily be explained to families of children with diabetes. For children with access to an experienced health care team and diabetes technologies a currently realistic target can be at least half of the time in normoglycemic range, i.e., TITR >50%.}, issn = {0149-5992} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_berghandreas_2025_3, title = {Utbildning och demokrati : En reflektion om faran med att tänka kring kvalitet som ett innehållslöst begrepp i singular}, author = {Bergh, Andreas}, year = {2025}, pages = {63--71}, url = {2030922}, language = {swe}, publisher = {Linnaeus University Press}, abstract = {Under de senaste decennierna har den utbildningspolitiska styrningen förändrats på en rad olika sätt, ofta legitimerad med referens till svepande påståenden om kvalitet. I den här texten riktas fokus mot relationen mellan utbildning och demokrati, med syftet att utmana den ofta förgivettagna föreställningen om kvalitet som ett singulärt och innehållslöst begrepp. Som empiriskt exempel används den statliga utredning om svensk lärarutbildning som presenterades hösten 2024. En förändrad omvärld reser viktiga frågor om kontinuitet och förändring, och påminner om vikten av att fortsatt uppmärksamma komplexa maktförhållanden och att bygga vidare på den kunskapsbas som tidigare generationer forskare bidragit med.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_brauerjohn_2025_3, title = {Utestänga eller undanta? Om aktivering av försörjningsstödstagare nära pensionsålder}, author = {Brauer, John and Panican, Alexandru and Jönsson, Anders}, year = {2025}, journal = {Arbetsmarknad & Arbetsliv}, volume = {31}, number = {4}, pages = {30--51}, url = {2028141}, language = {swe}, publisher = {Arbetsvetenskap vid Karlstads universitet}, keywords = {activation; social assistance; elderly; aktivering; försörjningsstöd; äldre}, abstract = {Det ekonomiska biståndet i Sverige utmärks av betoning på villkorande av ekonomiskt stöd via aktivering. Syftet med artikeln är att öka förståelsen för aktivering av försörjningsstödstagare nära pensionsåldern utifrån intervjuer med kommunala chefer inom arbetsmarknad och försörjning i olika kommuner. Det föreligger skillnader där vissa intervjupersoner betonar vikten att inte ta hänsyn till försörjningsstödstagares ålder medan andra betonar motsatsen. Vidare forskning är angeläget givet det väntade kravet på kommuner attaktivera försörjningsstödstagare, inte minst vad individanpassning innebär i aktiveringsarbete.;Swedish Social assistance is characterised by conditionality through activation. The aim of this article is to enhance understanding of whether, and how, municipalities consider age - particularly focusing on unemployed individuals approaching retirement age - in their efforts to activate recipients. To address this aim, municipal managers and planners were interviewed. Differences emerged, with some interviewees emphasising the importance of not considering the age of social assistance recipients, while others stressed the opposite. Further research is warranted, given the expected requirement for municipalities to activate recipients of social assistance - especially in terms of what individual adaptation means within activation.}, issn = {1400-9692} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_31, title = {Utgifter för effektivisering av verksamhet inför försäljning var avdragsgilla}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031700}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {Den 26 maj 2025 kom Högsta förvaltningsdomstolens dom i mål nr 307-24 och 308-24. Domen avser om avdragsrätt för konsulttjänster som avser effektiviseringen av ett företags verksamhet inför avyttringen av en koncern. Eleonor Kristoffersson, professor i skatterätt, analyserar domen.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_rivastorrubiam_2025, title = {UTILITY OF MOUSE MODELS OF LUPUS FOR CLINICAL RESEARCH AND DRUG TESTING}, author = {Rivas-Torrubia, M. and Morell, M. and Makowska, Z. and Kageyama, J. and Buttgereit, A. and Lindblom, J. and Consortium, P. Cytometry and Parodis, I. and Beretta, L. and Lesche, R. and Mcdonald, F. and Alarcon-Riquelme, M. and Barturen, G.}, year = {2025}, journal = {Annals of the Rheumatic Diseases}, volume = {83}, number = {Suppl. 1}, doi = {10.1136/annrheumdis-2024-eular.2023}, url = {1953971}, language = {eng}, publisher = {Elsevier}, keywords = {autoantibodies; '-omics; animal models}, abstract = {Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a diverse pathophysiology triggered by the loss of self-tolerance, resulting in inflammation and tissue damage in multiple organs. The use of animal models has been instrumental in advancing our understanding of SLE. The elimination of the requirement for animal models in the FDA’s drug approval process prompts a reevaluation of their role.Objectives: We aim to define a molecular framework for the future design of preclinical studies in SLE, helping researchers in the selection of mouse models and appropriate time point of study based on the molecular pathways and their relationship with human disease.Methods: To address this, a 4 timepoint longitudinal study was conducted using four different spontaneous SLE mouse models: MRLlpr/lpr, NZB/W, BXSB.Yaa, and TLR7.Tg6. RNA-Seq from whole-blood, spleen, and kidney, flow-cytometry from spleen, cytokines and autoantibodies in serum were profiled. All data was investigated using both, longitudinal differential expression analysis as well as individual cross-sectional analysis of each time-point. Molecular and flow-cytometry data from blood from SLE patients from the PRECISESADS project was integrated with mouse data using the MEFISTO software, allowing us to integrate direct relationships between human and mouse along the progression of disease.Results: Mouse models were extensively characterized at the molecular level. In the spleen, lymphopenia mimicking that occurring in the human and age-associated B cells were in common between mouse models, while neutrophil and cytotoxic lymphocyte expansions differentiated the models. TLR7-involved models showed important transcriptional dysregulation in the spleen as compared to non-TLR7 models, whose dysregulation was primarily in the kidney. Molecular changes were associated with severity across all models, with splenic changes preceding kidney damage and suggesting the ideal moment to study early immune pathogenic processes.Human and mouse molecular integration showed a shared interferon-mediated pathway with MRLlpr/lpr and TLR7.Tg6 models associated with hematological and constitutional clinical domains, but at different timepoints. The neutrophil-mediated inflammatory pathway was shared between humans, MRLlpr/lpr, BXSB.Yaa and TLR7.Tg6 models and related to renal and cutaneous clinical human domains.Conclusion: The findings provide a valuable framework for future experimental design involving SLE mouse models, demonstrating their continued usefulness in investigating the elusive pathogenesis and heterogeneity of SLE.}, issn = {0003-4967} } @book{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssonmagnus_2025_3, title = {Uttagsbeskattning och underprisöverlåtelser inom koncerner : samt vissa andra skattefrågor som relaterar till omstruktureringar}, author = {Kristoffersson, Magnus}, year = {2025}, url = {1993538}, language = {swe}, publisher = {Iustus Förlag}, keywords = {uttagsbeskattning; underprisöverlåtelser; koncernbeskattning; underskottsföretag; underskott; utdelningar}, abstract = {Boken utgör en vetenskaplig studie som främst kretsera kring reglerna i 22 och 23 kap Inkomstskattelagen om uttagsbeskattning och underprisöverlåtelser. Även regelverken rörande skattefria utdelningar och kapitalvinster på näringsbetingade andelar (24 och 25 a kap IL), koncernbidrag i 35 kap. IL och underskott i 40 kap. IL berörs i framställningen. } } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_olssonjan_2025_2, title = {Utvärdering ur ett etiskt perspektiv}, author = {Olsson, Jan and Petersén, Anna}, year = {2025}, pages = {157--174}, url = {2019084}, language = {swe}, publisher = {Studentlitteratur AB}, keywords = {utvärdering; värdepluralism; pragmatism}, abstract = {Trots ett starkare fokus på etik inom offentlig verksamhet kan vi inte skönja en etikvåg inom utvärderingsfältet, möjligen en krusning på vattenytan med betydelse på sikt. Vi argumenterar för att etisk utvärdering kan hjälpa uppdragsgivare att förstå och förklara prestationer och resultat i utvärderande verksamheter. Det kan ske genom en nyanserad etisk analys som också kan bidra med goda lösningar för att hantera värdekonflikter och dysfunktionella praktiker. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_forslidrikard_2025, title = {Vaccination strategies for different contact patterns : weighing epidemiological against economic outcomes}, author = {Forslid, Rikard and Herzing, Mathias}, year = {2025}, journal = {International Journal of Health Economics and Management}, volume = {25}, number = {1}, pages = {131--157}, doi = {10.1007/s10754-024-09384-1}, url = {1900877}, language = {eng}, publisher = {Springer}, keywords = {covid-19; pandemics; sir-model; vaccination}, abstract = {The aim of this paper is to shed light on the economic and epidemiological trade-offs that emerge when choosing between different vaccination strategies. For that purpose we employ a setting with three age groups that differ with respect to their fatality rates. The model also accounts for heterogeneity in the transmission rates between and within these age groups. We compare the results for two different contact patterns, in terms of the total number of deceased, the total number of infected, the peak infection rate and the economic gains from different vaccination strategies. We find that fatalities are minimized by first vaccinating the elderly, except when vaccination is slow and the general transmission rate is relatively low. In this case deaths are minimized by first vaccinating the group that is mainly responsible for spreading of the virus. With regard to the other outcome variables it is best to vaccinate the group that drives the pandemic first. A trade-off may therefore emerge between reducing fatalities on the one hand and lowering the number of infected as well as maximizing the economic gains from vaccinations on the other hand.}, issn = {2199-9023} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_drakenberganna_2025_3, title = {Vad kan vi göra för familjen? : Stödjande respektive icke stödjande omständigheter vid stor kirurgi hos vuxna patienter}, author = {Drakenberg, Anna}, year = {2025}, url = {1999225}, language = {swe} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_eliassonkent_2025, title = {Vad kan vi lära av var i landet näringslivet lokaliserar sin forskning och utveckling?}, author = {Eliasson, Kent and Hansson, Pär and Lindvert, Markus}, year = {2025}, journal = {Ekonomisk Debatt}, volume = {53}, number = {4}, pages = {33--45}, url = {1979831}, language = {swe}, publisher = {Nationalekonomiska Föreningen}, abstract = {De studier som redovisas i artikeln av var näringslivets FoU är förlagd visar att den viktigaste lokaliseringsfaktorn är tillgång till kvalificerad FoU-personal. För att kunna upprätthålla avancerad FoU-verksamhet och förbli internationellt konkurrenskraftiga är det väsentligt att företagen klarar kompetensförsörjningen. Här har staten en uppgift att bidra till detta Som ett resultat av samlokaliseringsfördelar -- ger upphov till kunskapsspridning och lärande -- sker den absoluta majoriteten av både näringslivets och akademins FoU i de stora arbetsmarknadsregionerna. Det är därför betydelsefullt att en fortsatt tillväxt i dessa möjliggörs genom nödvändiga investeringar i infrastruktur och bostäder. }, issn = {0345-2646}, file = {https://oru.diva-portal.org/smash/get/diva2:1979831/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gerdinmarcus_2025_2, title = {Validating and extending the unified model of information security policy compliance}, author = {Gerdin, Marcus}, year = {2025}, journal = {Information and Computer Security}, volume = {33}, number = {1}, pages = {25--48}, doi = {10.1108/ICS-12-2023-0263}, url = {1897119}, language = {eng}, publisher = {Emerald Group Publishing Limited}, keywords = {unified model of information security policy compliance; umispc; information security policy; non-compliance; compliance; information system security management}, abstract = {Purpose: The purpose of this study is to further validate and extend the unified model of information security policy compliance (UMISPC) developed by Moody et al. (2018).Design/methodology/approach: To be able to compare the results of this study and those reported by Moody et al. (2018) (and followers), the same quantitative data collection method (questionnaire) and variable measurement instruments were used. Specifically, questionnaire data were collected from a department within a Swedish governmental organization comprising 150 employees. Of these, 90 answered the questionnaire which rendered a response rate of 60%. Following Moody et al. (2018), the collected data were analyzed by means of structural equation modeling.Findings: This study generally provides empirical support for the original UMISPC as a large majority of the findings are in line with those reported by Moody et al. (2018). However, it also suggests important differences and boundary conditions.Originality/value: This study extends the original study of Moody et al. (2018) and subsequent replication studies by testing it in a new national/organizational context. Based on their call for future research, it also develops and empirically tests the effects of a new, socially visible information system security violation scenario. Related to this, this study also revisits the role of the variable subjective norms for better understanding employee non-/compliance to information security policies by suggesting that their effects may be indirect (i.e. running through other variables in the UMISPC) rather than direct.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_josefssonsamueljara_2025, title = {Validation of the Scandinavian neurotrauma committee guidelines - A retrospective study in region Örebro county}, author = {Josefsson, Samuel Jara and Trivedi, Dhanisha and Vigren, Patrick and Büki, Andras}, year = {2025}, journal = {Brain and Spine}, volume = {5}, doi = {10.1016/j.bas.2025.104231}, url = {1948217}, language = {eng}, publisher = {Elsevier}, keywords = {adults; ct; clinical guidelines; traumatic brain injury; validation}, abstract = {Introduction: Traumatic Brain Injury (TBI) is a global health concern and a leading cause of trauma-related death worldwide. Computed tomography (CT) scan is the gold standard for screening for intracranial bleeding following TBI. Most cases of TBI are mild, with negative CT scans. Different instruments and guidelines are employed to better predict which patients need a CT scan and to minimise unnecessary radiation exposure and save resources. One such instrument is the Scandinavian Neurotrauma Committee guidelines.Research question: To validate and examine adherence to the Scandinavian Neurotrauma Committee guidelines in Region Örebro County.Material and methods: We executed a retrospective study with review of patient records and data analysis. Descriptive and comparative statistics were used, along with binary logistic regression analysis to account for confounding factors.Results: A total of 505 cases were reviewed. Sensitivity of the guidelines was measured at 95% with specificity at 29%. The positive and negative predictive values were 0.77 and 0.69, respectively. A total of 17 false negative cases were found. One case required surgery, during which a chronic subdural hematoma was identified. Adherence to guidelines was 56%, with the lack of analysis of S100B primarily accounting for non-adherence. A total of 54 CT scans were performed outside of guideline indications.Discussion and conclusions: The guidelines can effectively predict which patients need a CT scan. Increased adherence could potentially decrease the number of CT scans, while inclusion of older age limit as an independent rule-in law for CT scans would increase patient safety.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wngdahljosefin_2025, title = {Validation of the Swedish version of HLS19-Q12 : a measurement for general health literacy}, author = {Wångdahl, Josefin and Jaensson, Maria and Dahlberg, Karuna and Bergman, Lina and Keller Celeste, Roger and Doheny, Megan and Agerholm, Janne}, year = {2025}, journal = {Health Promotion International}, volume = {40}, number = {4}, doi = {10.1093/heapro/daaf132}, url = {1988355}, language = {eng}, publisher = {Oxford University Press}, keywords = {health literacy; hls19-q12; m-pohl; measurements; validation; cognitive interviews; sweden}, abstract = {Health literacy (HL) is a critical determinant of health, as it affects health behavior and outcomes, in addition to equity in health. This study aimed to translate, culturally adapt, and validate the Swedish version of HLS19-Q12 (HLS19-Q12-SE). The HLS19-Q12 is a widely used instrument that consists of 12-items and is often used to assess HL in Europe. A convergent mixed-methods design was applied, including cognitive interviews (n = 8) and psychometric testing with a survey sample (n = 374) and test-retest group (n = 28). The instrument was forward and backwards translated and culturally adapted. Data was analyzed using confirmatory and exploratory factor analysis, correlation testing, and reliability assessments. Cognitive interviews explored the clarity, interpretation, and contextual relevance of the items. Participants found the HLS19-Q12-SE clear and easy to understand, though some reported difficulties with unfamiliar health situations and uncertainty of the term "health information." Based on the interviews, the examples for one of the items were culturally adapted. Psychometric testing showed good feasibility, no floor or ceiling effects on scale level, and moderate positive correlations with other HL instruments, supporting internal and external validity. Structural validity was confirmed, and internal consistency and test-retest reliability were satisfactory. However, ceiling effects were observed at the dichotomous item level, and correlations with self-rated health and social status were low. The HLS19-Q12-SE is a reliable and valid instrument for assessing general HL in Sweden. While psychometric properties were strong overall, future research should address ceiling effects on item level and explore the instrument's performance in more diverse populations.}, issn = {0957-4824} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bruinsmaflorisfe_2025, title = {Validation of the Swiss-Finnish Bariatric Metabolic Outcome Score within a large prospective registry cohort}, author = {Bruinsma, Floris F. E. and Hurme, Saija and Peterli, Ralph and Stenberg, Erik and Nienhuijs, Simon W. and Grönroos, Sofia and Våge, Villy and Bueter, Marco and Ottosson, Johan and Liem, Ronald S. L. and Salminen, Paulina}, year = {2025}, journal = {British Journal of Surgery}, volume = {112}, number = {6}, doi = {10.1093/bjs/znaf106}, url = {1966209}, language = {eng}, publisher = {Oxford University Press}, abstract = {Background: The Swiss-Finnish Bariatric Metabolic Outcome Score (SF-BARI Score), based on merged data of two RCTs, is a composite endpoint designed to evaluate and categorize outcomes after metabolic bariatric surgery (MBS). The aim of this study was to externally validate the score using registry data.Methods: Individual patient data were included from the Dutch Audit for Treatment of Obesity, the Scandinavian Obesity Surgery Registries (SOReg-Sweden and SOReg-Norway), and the merged RCT data used for establishing the SF-BARI Score. All patients undergoing primary MBS from January 2010 to June 2018, with complete baseline characteristics, as well as complete 1- and 5-year follow-up data, were included. The mean total score and distribution were compared between the combined registry and merged RCT data.Results: There was no statistically significant difference in the mean SF-BARI Score between the registries (21 603 patients) and merged RCTs (457 patients) at 5 years (90.9 versus 89.1 points; difference = 1.8 (95% c.i. -1.0 to 4.7); P = 0.212), and the score distribution was similar. Statistically significant differences in baseline characteristics existed regarding sex (male 20.9% versus 29.3%), type 2 diabetes (16.7% versus 33.9%), hypertension (30.4% versus 66.1%), dyslipidaemia (13.7% versus 46.5%), obstructive sleep apnoea syndrome (12.0% versus 17.4%), and sleeve gastrectomy (SG) rate (21.0% versus 49.9%) (P < 0.001). The mean score estimate at 5 years in Roux-en-Y gastric bypass was 11.2 (95% c.i. 10.2 to 12.2) points higher compared with SG (P < 0.001).Conclusion: This study verified the feasibility of the SF-BARI Score, enabling standardized reporting and allowing for comparison of different treatment modalities.}, issn = {0007-1323} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_haschenina_2025_2, title = {Value propositions and facilitating promises of value — The case of the Swedish Public Employment Service}, author = {Hasche, Nina and Höglund, Linda}, year = {2025}, journal = {International Public Management Journal}, volume = {28}, number = {4}, pages = {511--535}, doi = {10.1080/10967494.2024.2436378}, url = {1924603}, language = {eng}, publisher = {Routledge}, abstract = {Through a case study, this article illustrates the value creation process of how value propositions are created and developed at the Swedish Public Employment Service from the theoretical stance of public service logic and ecosystem thinking. Previous research has devoted scant attention to value propositions as promises of value, i.e., before the user creates value-in-use. This case study contributes to the literature on public administration and management, and more precisely on the growing research of PSL, by analyzing how public service organizations interact with their service users to facilitate value creation based on promises of value throughout the value process. In this paper, the value process is understood as three interlocking spheres: the provider sphere, user sphere, and joint sphere.}, issn = {1096-7494} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssonfredrik_2025_5, title = {Value-Based Compliance Theory}, author = {Karlsson, Fredrik and Hedström, Karin}, year = {2025}, pages = {2717--2721}, url = {1927407}, language = {eng}, publisher = {Springer Nature} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_kisstams_2025_1, title = {VAR Models with Fat Tails and Dynamic Asymmetry}, author = {Kiss, Tamás and Mazur, Stepan and Nguyen, Hoang and Österholm, Pär}, year = {2025}, pages = {67--88}, doi = {10.1007/978-3-032-00110-8_5}, url = {2012568}, language = {eng}, publisher = {Springer}, abstract = {In this chapter, we extend the standard Gaussian stochastic volatility Bayesian VAR by employing the generalized hyperbolic skew Student’s t distribution for the innovations. Allowing the skewness parameter to vary over time, our specification permits flexible modelling of innovations in terms of both fat tails and—potentially dynamic—asymmetry. In an empirical application using US data on industrial production, consumer prices and economic policy uncertainty, we find support—although to a moderate extent—for time-varying skewness. In addition, we find that shocks to economic policy uncertainty have a negative effect on both industrial production growth and CPI inflation.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_17, title = {Varför organiserar sig vissa män kring sin upplevelse av ensamhet?}, author = {Johansson Wilén, Evelina}, year = {2025}, url = {2011525}, language = {swe}, abstract = {Varför organiserar sig vissa män kring sin upplevelse av ensamhet – och hur blir den ensamheten en politisk fråga? Föredraget utforskar hur olika grupper av män försöker förstå och hantera sin ofrivilliga ensamhet. Genom exempel som incel-rörelsen visar föredraget hur personlig frustration kan förvandlas till kollektiva berättelser om kön, makt och orättvisa – och vad detta säger om samtida föreställningar om manlighet, närhet och kärlek.} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_vantourpeter_2025, title = {Variation Counterpoint in Eighteenth- Century Naples and Bologna}, author = {van Tour, Peter}, year = {2025}, pages = {1095--1116}, url = {1932675}, language = {eng}, publisher = {Oxford University Press}, keywords = {partimento; counterpoint; naples; music theory; variation} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_larssonannakarinl_2025, title = {VERKSAM : Professionals’ Experiences of Risk Assessment and Risk Management in Domestic Violence and Stalking}, author = {Larsson, Anna-Karin L.}, year = {2025}, url = {2004761}, language = {eng}, keywords = {intimate partner violence; riskmanagement}, abstract = {Intimate partner violence (IPV) and stalking is a pervasive societal problem violating human rights, where every third woman reports being victimized. Such violence causes a major strain on both victims and society, where resources provided to reduce violence show low effect since both rates of prevalence and recidivism remains high and quality of life remains low for victims and their children, specifically in rural areas. The work to prevent such violence needs effective risk management, which currently is not the case.The risk management conducted by social services in collaboration with the police is problematic since it is done from different perspectives in an unstructured way. The RiskSam is a structured risk management model developed to improve collaboration within and between agencies. The RiskSam provides the link between risk assessment and risk management.The overall aim of this longitudinal research program (2019-2025) is to improve and implement a sustainable and evidence-based model, the RiskSam, within the Swedish social services, and to evaluate the effects of working with the model in terms of violence reduction, cost-effective collaboration with the police, and quality of life for victims, in cases of IPV and stalking with both a rural and child perspective. A theoretical development of theory based on the Risk-Need-Responsivity principle will be conducted.The research program consists of a mixed method design divided into several sub-projects. In this symposium findings from four of them will be presented and discussed. Strand, Susanne(1)    Petersson, Joakim(1)    Källström, Åsa(1)    Larsson, Anna-Karin(1)    Vikander, Martina(2)    (1) Örebro University  (2) School pf Behavioral, Social and Legal Sciences, Örebro University } } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_warnickecamilla_2025_1, title = {Video Relay Service}, author = {Warnicke, Camilla}, year = {2025}, url = {1996714}, language = {eng}, publisher = {Routledge} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_anderssonsusanna_2025, title = {Vilka är VI, NI och DE i svenskspråkiga sportpoddar? Om klusivitet i en utvidgad talsituation}, author = {Andersson, Susanna}, year = {2025}, pages = {68--69}, url = {1961824}, language = {swe}, keywords = {interaktion; klusivitet; pronomen; talspråk; podcast; samtalspoddar}, abstract = {Poddmediets växande popularitet under de senaste två decennierna har ofta förklarats med dess förmåga att skapa en känsla av närhet till lyssnaren – en intimitet som företrädesvis tillskrivs det individuella och mobila lyssnandet, den tekniska tillgängligheten, liksom poddarnas innehåll och format (ex. Berry 2016). Drygt hälften av poddlyssnarna säger sig också ha en så stark personlig koppling till deltagarna i sina favoritpoddar att de betraktar dessa som vänner (Acast 2024).Sambandet mellan deltagarnas språk och lyssnarnas engagemang har undersökts på aggregerad nivå i studier av utländska poddar (ex. Reddy et al. 2021; Markowitz 2025). Med pragmatik som teoretisk utgångspunkt analyserar jag i mitt pågående avhandlingsprojekt hur interaktionell intimitet konstrueras i olika kategorier av svenskspråkiga samtalspoddar. I det här föredraget riktas fokus mot den skiftande klusiviteten (Filimonova 2005; Pavlidou 2014) i sportpoddarnas tilltal och omtal. Medan tidigare studier av svenskt talspråk främst har kartlagt hur 1 persons pronomen VI används för att konstruera identiteter och gemenskaper (ex. Engblom 2004; Moberg & Eriksson 2013; Andersson 2021), omfattar denna studie även 2 och 3 persons pronomen NI och DE, och den roll dessa spelar i konstruktionen av interaktionell intimitet i poddar (Adler Berg 2023; Euritt 2023). Med exempel från tolv svenskspråkiga sportpoddar synliggörs hur poddeltagarna (re)konstruerar supporteridentiteten i och genom skiftningarna i klusivitet och pronomenval – såväl i relation till andra deltagare, lyssnare och supportrar, som till enskilda händelser kopplade till klubbar, spelare och ledare. Utifrån dessa resultat presenterar jag under föredraget ett förslag till typologi för klusivitet i svenskt talspråk.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_borgalexander_2025_1, title = {Virtual Patient Simulations Using Social Robotics Combined With Large Language Models for Clinical Reasoning Training in Medical Education : Mixed Methods Study}, author = {Borg, Alexander and Georg, Carina and Jobs, Benjamin and Huss, Viking and Waldenlind, Kristin and Ruiz, Mini and Edelbring, Samuel and Skantze, Gabriel and Parodis, Ioannis}, year = {2025}, journal = {Journal of Medical Internet Research}, volume = {27}, pages = {e63312}, doi = {10.2196/63312}, url = {1943210}, language = {eng}, publisher = {JMIR Publications}, keywords = {clinical reasoning; large language models; medical education; medical students; social robotics; sustainable learning; virtual patients}, abstract = {BACKGROUND: Virtual patients (VPs) are computer-based simulations of clinical scenarios used in health professions education to address various learning outcomes, including clinical reasoning (CR). CR is a crucial skill for health care practitioners, and its inadequacy can compromise patient safety. Recent advancements in large language models (LLMs) and social robots have introduced new possibilities for enhancing VP interactivity and realism. However, their application in VP simulations has been limited, and no studies have investigated the effectiveness of combining LLMs with social robots for CR training.OBJECTIVE: The aim of the study is to explore the potential added value of a social robotic VP platform combined with an LLM compared to a conventional computer-based VP modality for CR training of medical students.METHODS: A Swedish explorative proof-of-concept study was conducted between May and July 2023, combining quantitative and qualitative methodology. In total, 15 medical students from Karolinska Institutet and an international exchange program completed a VP case in a social robotic platform and a computer-based semilinear platform. Students' self-perceived VP experience focusing on CR training was assessed using a previously developed index, and paired 2-tailed t test was used to compare mean scores (scales from 1 to 5) between the platforms. Moreover, in-depth interviews were conducted with 8 medical students. RESULTS: The social robotic platform was perceived as more authentic (mean 4.5, SD 0.7 vs mean 3.9, SD 0.5; odds ratio [OR] 2.9, 95% CI 0.0-1.0; P=.04) and provided a beneficial overall learning effect (mean 4.4, SD 0.6 versus mean 4.1, SD 0.6; OR 3.7, 95% CI 0.1-0.5; P=.01) compared with the computer-based platform. Qualitative analysis revealed 4 themes, wherein students experienced the social robot as superior to the computer-based platform in training CR, communication, and emotional skills. Limitations related to technical and user-related aspects were identified, and suggestions for improvements included enhanced facial expressions and VP cases simulating multiple personalities.CONCLUSIONS: A social robotic platform enhanced by an LLM may provide an authentic and engaging learning experience for medical students in the context of VP simulations for training CR. Beyond its limitations, several aspects of potential improvement were identified for the social robotic platform, lending promise for this technology as a means toward the attainment of learning outcomes within medical education curricula.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_lassenkarstenl_2025, title = {Virtual Reality Is Safe and Can Reduce In-Hospital Anxiety and Pain : A Systematic Review With Meta-Analyses and Trial Sequence Analyses}, author = {Lassen, Karsten L. and Hermander, Kristian and Jildenstål, Pether and Wagner, Nanna and Augustinsson, Annelie and Sjöberg, Carina and Geisler, Anja}, year = {2025}, journal = {European Journal of Pain}, volume = {29}, number = {10}, doi = {10.1002/ejp.70165}, url = {2011944}, language = {eng}, publisher = {John Wiley & Sons}, abstract = {BACKGROUND AND OBJECTIVE: Virtual reality (VR) is a rapidly evolving technology that is currently utilized in hospital settings for various types of surgical procedures. The extent to which VR is evident in improving patient outcomes is unknown. This systematic review assesses the impact of VR on adult patients undergoing elective surgical procedures.DATABASES AND DATA TREATMENT: The following databases were sought: CENTRAL, MEDLINE, EMBASE, and CINAHL. All studies published after 2017 were included. The risk of bias was assessed using the ROB2 and ROBINS-I. Meta-analyses and Trial Sequential Analyses were performed, and the quality of evidence was evaluated using the GRADE approach for the randomised controlled trials.RESULTS: A total of 37 full-text studies (n = 3152) were included. VR significantly reduced anxiety measured by the Numeric Rating Scale (p < 0.0001) and the State-Trait Anxiety Inventory (p = 0.008). Furthermore, Numeric Rating Scale pain was significantly reduced (p < 0.00005), with a significantly shorter recovery time and a non-significant improvement in patient satisfaction. Adverse events were infrequent and mild, with no serious adverse events reported. The risk of bias was primarily "some concerns", and the certainty of evidence ranged from moderate to low.CONCLUSIONS: VR appears effective in reducing pain and anxiety in adult patients in an in-hospital setting. It offers a relatively safe adjunct to standard care with minimal side effects. However, heterogeneity in outcomes and the risk of bias suggest a need for more standardised, high-quality trials.SIGNIFICANCE STATEMENT: This systematic review with meta-analysis and trial sequential analysis provides updated evidence that virtual reality can significantly reduce anxiety and pain in patients undergoing surgical procedures. Through combining recent RCTs and cohort studies with robust methodological approaches, this review strengthens the evidence for VR as an effective non-pharmacological intervention. With minimal adverse events and significant improvements in recovery time, VR represents a scalable tool that can strengthen multimodal strategies and promote safer and more comfortable patient experiences.}, issn = {1090-3801} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_carlssonjanolof_2025, title = {Visual Outcomes and Prognostic Factors in Epiretinal Membrane Foveoschisis and Lamellar Macular Hole Surgery : A Retrospective Study}, author = {Carlsson, Jan-Olof and Wirén, Anders and Dukay, Maria and Mageed, Koteiba and Crafoord, Sven}, year = {2025}, journal = {Clinical Ophthalmology}, volume = {19}, pages = {3133--3144}, doi = {10.2147/opth.s532123}, url = {1994144}, language = {eng}, publisher = {Dove Medical Press}, keywords = {erm foveoschisis; lamellar macular hole; vision improvement; preoperative factor}, abstract = {Purpose: To assess vision outcomes, risk of complications and whether age, gender, specific OCT changes and preoperative vision affect the prognosis for postoperative vision development. We seek to clarify the prognosis of LMH after surgery and assess whether complications can be reduced with appropriate management.Methods: This retrospective study includes consecutive Lamellar Macular Hole (LMH) surgeries at Örebro University Hospital (2013– 2019), re-evaluated using the OCT-based consensus definition. Cases were classified as Epiretinal Membrane Foveoschisis (ERM-F) or LMH. Pre- and postoperative data were collected from medical records. Statistical analyses were performed with support from medical statisticians.Results: Both the ERM-F and LMH groups showed Highly significant visual development (p-adj = 0.0010 and 0.0012 respectively), with a median visual improvement of 90% and 38%, respectively. Even the older LMH group, in which the majority (81%) exhibited pathological OCT findings, showed a median improvement of 61% and a significant visual improvement (adjusted p = 0.026).Conclusion: The results indicate good potential for visual improvement in both groups. Even if the LMH group experiences positive vision improvement, these patients would experience further improvement without the aforementioned OCT changes. Early surgery is highly recommended, ideally before photoreceptor damage occurs; if already present, it should be performed as soon as possible to prevent further OCT pathology.}, issn = {1177-5467} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_ervolaura_2025_6, title = {Väktarvåldet – lagligt tvångsmedel eller brottsligt övervåld?}, author = {Ervo, Laura and Kaakinen, Miika}, year = {2025}, pages = {51--65}, url = {2004367}, language = {swe}, publisher = {Iustus förlag} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kelemenkatalin_2025_1, title = {Vörös Imre válogatott különvéleményeinek gyűjteményéről}, author = {Kelemen, Katalin}, year = {2025}, journal = {Jogtudományi Közlöny}, number = {10}, pages = {479--481}, doi = {10.59851/jk.79.10.6}, url = {1956897}, language = {hun}, publisher = {ORAC Kiadó}, keywords = {dissenting opinions; judicial dissent; constitutional court; judicial decision-making}, issn = {0021-7166} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_liedbergfredrik_2025_2, title = {Waiting time in diagnosis and extirpative surgery and association with survival and stage progression in upper tract urothelial carcinomas}, author = {Liedberg, Fredrik and Hagberg, Oskar and Häggström, Christel and Aljabery, Firas and Gårdmark, Truls and Jahnson, Staffan and Jerlström, Tomas and Ströck, Viveka and Söderkvist, Karin and Ullén, Anders and Holmberg, Lars and Bobjer, Johannes}, year = {2025}, journal = {BJUI Compass}, volume = {6}, number = {9}, doi = {10.1002/bco2.70093}, url = {2000931}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {diagnostic delay; radical nephroureterectomy; segmental ureterectomy; total delay; treatment delay; upper tract urothelial carcinoma}, abstract = {OBJECTIVES: To investigate the association between waiting time and outcomes in patients with upper tract urothelial carcinomas (UTUC).PATIENTS AND METHODS: We studied a population-based cohort of 858 patients in BladderBaSe 2.0 subjected to extirpative surgery for UTUC 2015-2019 in Sweden. Diagnostic waiting time (from referral to diagnosis, reference <1 week), treatment waiting time (from diagnosis to surgery, reference <5 weeks) and total waiting time (reference <10 weeks) were investigated in relation to disease-specific (DSS) and overall survival (OS) by multivariable Cox regression models. To further explore these associations, stage progression from preoperatively recorded clinical tumour stage to pathological tumour stage in the extirpated specimen was assessed by logistic regression.RESULTS: Total waiting time was not associated with DSS, OS or stage progression. A diagnostic waiting time between 1 and 4 weeks was associated with better DSS (HR 0.57 [95% CI 0.35-0.94]) and OS (HR 0.60 [95% CI 0.41-0.87]). In the strata of patients with UTUC in the renal pelvis, a diagnostic waiting time > 4 weeks was associated with stage progression (OR 2.44 [95% CI 1.00-5.95]), and in patients with UTUC in the ureter, a treatment waiting time between 5 and 10 weeks was associated to worse DSS (HR 2.85 (95% CI 1.03-7.89).CONCLUSIONS: In general, shorter care pathways were linked to beneficial survival estimates, yet some estimates may be influenced by selection bias due to prioritizing short waiting times for patients with advanced and/or overt symptomatic tumours. Stage progression with increased waiting time may indicate an underlying causal mechanism.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_wintonpatrik_2025_2, title = {War, credit and improvement : The political economy of the fiscal-military state in Sweden, 1700-1815}, author = {Winton, Patrik}, year = {2025}, url = {1966386}, language = {eng}, abstract = {According to many existing narratives, the eighteenth century witnessed a decline of Sweden's position in the European states system as it tried to come to terms with a rising Russian Empire in the east and a growing Prussian state in the south. According to the same narratives, Sweden tried to compensate for this declining geopolitical position by expanding long-distance trade in Asia, the Americas and the Mediterranean, and by promoting internal cultivation. Unlike the bellicose seventeenth century, wars and preparations for wars have therefore not been seen as drivers of economic, political and social developments in Sweden during the eighteenth century, even though Sweden participated in several of the major conflicts during the period 1700-1815: the Great Northern War (1700-1721), the Russo-Swedish War of 1741-1743, the Seven Years' War (1757-1762), the Russo-Swedish War of 1788-1790 and the Napoleonic Wars (1805-1814). In my presentation, I will show that the narrative of decline is too simplistic, and that there were several changes made in both the financial and military infrastructure to improve the capacity of the Swedish state to cope with the changing international states system. I will pay particular attention to the system of credit and its implications for warfare; but the capacity of the military to procure necessary goods will also be examined.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_jnssonjessicah_2025, title = {“We Pupils Had to Hear…” Marginalised Youths’ Experiences of Racialising Language and Symbolic Violence in Swedish Schools}, author = {Jönsson, Jessica H.}, year = {2025}, journal = {Social Policy and Society}, volume = {24}, number = {1}, pages = {139--153}, doi = {10.1017/S1474746424000307}, url = {1903833}, language = {eng}, publisher = {Cambridge University Press}, keywords = {belonging; colonial discourse; marginalisation; racialising language; symbolic violence; migrant youths; sweden}, abstract = {Guided by Pierre Bourdieu’s theoretical approaches of symbolic capital and symbolic violence, this article examines the everyday mechanisms of ‘otherising’ language practices in schools that reinforce racism against marginalised youths in Sweden. The empirical material is based on focus group discussions and individual in-depth interviews with youths with migrant backgrounds in Sweden. The stories told by the participants in this study indicate how young people with immigrant backgrounds are discursively racialised and otherised as a group that does not belong to Swedish society, through the articulation of negative opinions, attitudes, and ideologies as part of established colonial discourses. It is argued that the marginalisation of migrants in Sweden, which is a consequence of social policy, has even resulted in utilisation of a marginalised language — one that deviates from the majority language in several different ways.}, issn = {1474-7464} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_krzyzanowskimichal_2025, title = {"We put family at the centre of social life" : conceptual flipsiding of the "family" in discursive-political strategies of the Polish populist far-right}, author = {Krzyzanowski, Michal and Krzyzanowska, Natalia}, year = {2025}, journal = {Social Semiotics}, doi = {10.1080/10350330.2025.2601614}, url = {2031141}, language = {eng}, publisher = {Routledge}, keywords = {conceptual flipsiding; discourse-conceptual analysis; critical discourse studies; family; gender; the far right}, abstract = {This article explores the conceptual redefinition of the "family" in the recent discourse of the Polish populist far-right. Looking at the far-right discourse as in many ways prototypical for contemporary, illiberal thinking about the "family," we look at a number of discourse-conceptual dynamics that showcase its intensified, political and ideological use. Of these, we pay special attention to the process of "conceptual flipsiding" i.e. a strategy whereby the meaning of key social and political concepts is purposefully made ambiguous before being endowed, or "infused," with various elements of openly illiberal understandings and imaginaries. Deploying Discourse-Conceptual Analysis (DCA), we show how the "family," typically for the illiberal imagination, is not only framed in a conservative or a (neo)traditionalist way, but how some of its key sister-notions - often incorporated from liberal-democratic catalogue (for example those related to various "rights") - are conceptually flipsided to strengthen the overall illiberal redefinition. We show thereby how the "family" thus becomes an entry point in the recontextualisation of wider public narratives and discursive traditions which, while redefining the "family," also effectively suppress issues of inter alia, women's rights, equal opportunities or any other than the strictly conservative visions of family, family planning or family and reproductive politics.}, issn = {1035-0330} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_andrndaniela_2025_7, title = {Welfare Persistence, Immigration, and Partnership Dynamics : Insights from Sweden’s 1990s Economic Crisis}, author = {Andrén, Daniela and Andrén, Thomas and Kahanec, Martin}, year = {2025}, url = {2003696}, language = {eng} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_cortesesamuele_2025_2, title = {What are the main cardiovascular risks of ADHD medications?}, author = {Cortese, Samuele and Chang, Zheng and Larsson, Henrik}, year = {2025}, journal = {Expert Opinion on Drug Safety}, doi = {10.1080/14740338.2025.2588601}, url = {2013565}, language = {eng}, publisher = {Taylor & Francis}, keywords = {adhd; cardiovascular; hypertension; risk; stimulants}, issn = {1474-0338} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_flewwellingluked_2025, title = {What are the potential mechanisms of fatigue-induced skeletal muscle hypertrophy with low-load resistance exercise training?}, author = {Flewwelling, Luke D. and Hannaian, Sarkis J. and Cao, Victor and Chaillou, Thomas and Churchward-Venne, Tyler A. and Cheng, Arthur J.}, year = {2025}, journal = {American Journal of Physiology - Cell Physiology}, volume = {328}, number = {3}, pages = {C1001--C1014}, doi = {10.1152/ajpcell.00266.2024}, url = {1925699}, language = {eng}, publisher = {American Physiological Society}, keywords = {strength training; hypertrophy; low-load; muscle failure; skeletal muscle growth}, abstract = {High-load resistance exercise (>60% of 1-repetition maximum) is a well-known stimulus to enhance skeletal muscle hypertrophy with chronic training. However, studies have intriguingly shown that low-load resistance exercise training (RET) (≤60% of 1-repetition maximum) can lead to similar increases in skeletal muscle hypertrophy as compared to high-load RET. This has raised questions about the underlying mechanisms for eliciting the hypertrophic response with low-load RET. A key characteristic of low-load RET is performing resistance exercise to, or close to, task failure, thereby inducing muscle fatigue. The primary aim of this evidence-based narrative review is to explore whether muscle fatigue may act as an indirect or direct mechanism contributing to skeletal muscle hypertrophy during low-load RET. It has been proposed that muscle fatigue could indirectly stimulate muscle hypertrophy through increased muscle fibre recruitment, mechanical tension, ultrastructural muscle damage, the secretion of anabolic hormones, and/or alterations in the expression of specific proteins involved in muscle mass regulation (e.g., myostatin). Alternatively, it has been proposed that fatigue could directly stimulate muscle hypertrophy through the accumulation of metabolic by-products (e.g., lactate), and/or inflammation and oxidative stress. This review summarizes the existing literature eluding to the role of muscle fatigue as a stimulus for low-load RET-induced muscle hypertrophy and provides suggested avenues for future research to elucidate how muscle fatigue could mediate skeletal muscle hypertrophy.}, issn = {0363-6143} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_baraldienrico_2025, title = {What can IMP gain from computer-based simulations?}, author = {Baraldi, Enrico and Guercini, Simone and Perna, Andrea and Prenkert, Frans}, year = {2025}, url = {2038841}, language = {eng}, keywords = {business networks; computer-based simulation; agent-based model (abm); complexity; case research}, abstract = {Computer-based simulations have become increasingly prevalent in social sciences and management studies, yet their application in industrial business network analysis remains limited. This paper aims to introduce computer-based simulation methods and explore their potential in studying business relationships and network dynamics, thereby supporting managerial decision-making. Despite the challenges posed by the open-system nature of industrial networks, simulation methods such as discrete event simulation (DES), system dynamics simulation (SDS), and agent-based modelling (ABM) offer valuable insights into complex, non-linear, and emergent processes. By leveraging extensive qualitative data from the IMP community, simulations can enhance theory development and address criticisms regarding the lack of systematic theory creation. This paper discusses the possibilities and limitations of these simulation models, emphasizing their role in advancing our understanding of industrial systems.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_barkerd_2025, title = {What do you think you are doing? How physical education researchers make scientific contributions}, author = {Barker, D and Ekberg, J. -E and Nyberg, G. and Larsson, H.}, year = {2025}, journal = {Sport, Education and Society}, doi = {10.1080/13573322.2025.2465588}, url = {1942037}, language = {eng}, publisher = {Routledge}, keywords = {bernstein; discipline; knowledge structure; physical education; scientific contribution}, abstract = {Scholars have expressed concern about stagnation in physical education research. Specifically, they have claimed that physical education researchers have been investigating the same topics, presenting the same solutions, and at times fail to build on - or in some cases, even acknowledge - existing scientific findings. These are serious assertions that call into question the enterprise of researching in physical education. In this paper, we evaluate the merits of these claims. Through a Bernsteinian reading of four illustrations, the thesis we develop is that physical education has a horizontal knowledge structure. This knowledge structure affects the ways that scholars make scientific contributions, or in other words, how they develop knowledge. Understanding the connection between the knowledge structure and how knowledge is developed draws attention to: (1) the modest ways in which researchers typically make contributions, (2) the routine nature of repetition in research, and (3) the responsibilities researchers have to acknowledge the work of other researchers. We suggest that more generally, a Bernsteinian interpretation of the examples may help researchers acknowledge and accept slow disciplinary development and gain clarity regarding how and in which areas they can contribute in the future.}, issn = {1357-3322} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bauduccosv_2025, title = {What Drives Girlfriends' Bedtimes? Experimental Effects of Social Technology Use and the Role of Friendship and Personality}, author = {Bauducco, S V and Schrooten, M G S and Gradisar, M.}, year = {2025}, journal = {Journal of Sleep Research}, doi = {10.1111/jsr.70238}, url = {2011848}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {adolescence; bedtime procrastination; experimental design; friendship dyads; social media; tv streaming}, abstract = {Technology use is often implicated in adolescent sleep difficulties, yet experimental evidence confirming its impact on bedtime is critically lacking. This study tested whether online socialising with friends delays bedtime compared to non-social online media use, while also considering the roles of friendship quality and personality. Seventeen pairs of female friends (N = 34; ages 16–18 years) spent two nights in a sleep laboratory: one night online socialising with their friend in another room (WhatsApp + Netflix), and one night watching Netflix alone without socialising. Condition order was counterbalanced across pairs. Bedtime was behaviorally observed using infrared cameras. The following morning, participants reported who initiated sleep and their reasons for going to bed. They also completed questionnaires on friendship quality, co-rumination, self-control, bedtime procrastination, and a sleep diary. Multilevel models accounted for the nested structure of repeated assessments within individuals within dyads. On average, participants went to bed later during online socialising than during non-social online use, although this difference was not statistically significant. However, higher friendship quality significantly predicted longer bedtime delays during online socialising, with delays up to 72 min. Feeling sleepy was the primary reason for sleep onset, rather than social motivations. Additionally, there were clear associations between self-reported sleep initiation and bedtime procrastination and behavioural observations of earlier and later bedtimes, respectively. These experimental findings suggest that online socialising may delay adolescent bedtimes, particularly among those with high-quality friendships. These results underscore the importance of addressing peer dynamics and individual differences in supporting healthy adolescent sleep.}, issn = {0962-1105}, file = {https://oru.diva-portal.org/smash/get/diva2:2011848/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_martinsigor_2025, title = {What events matter for exchange rate volatility?}, author = {Martins, Igor and Freitas Lopes, Hedibert}, year = {2025}, journal = {Quarterly Review of Economics and Finance}, volume = {104}, doi = {10.1016/j.qref.2025.102073}, url = {2013182}, language = {eng}, publisher = {Elsevier}, keywords = {stochastic volatility; macroeconomic announcements; sparsity; seasonality}, abstract = {This paper expands on stochastic volatility models by proposing a data-driven method to select the macroeconomic events most likely to impact volatility. The paper identifies and quantifies the effects of macroeconomic events across multiple countries on exchange rate volatility using high-frequency currency returns, while accounting for persistent stochastic volatility effects and seasonal components capturing time-of-day patterns. Given the hundreds of macroeconomic announcements and their lags, we rely on sparsity-based methods to select relevant events for the model. We contribute to the exchange rate literature in four ways: First, we identify the macroeconomic events that drive currency volatility, estimate their effects and connect them to macroeconomic fundamentals. Second, we find a link between intraday seasonality, trading volume, and the opening hours of major markets across the globe. We provide a simple labor-based explanation for this observed pattern. Third, we show that including macroeconomic events and seasonal components is crucial for forecasting exchange rate volatility. Fourth, our proposed model yields the lowest volatility and highest Sharpe ratio in portfolio allocations when compared to standard SV and GARCH models.}, issn = {1062-9769}, file = {https://oru.diva-portal.org/smash/get/diva2:2013182/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_botogarcadavid_2025, title = {What explains profit inefficiency in the restaurant industry? Evidence from Sweden}, author = {Boto-García, David and Demydyuk, Ganna and Carlbäck, Mats}, year = {2025}, journal = {Tourism Economics}, volume = {31}, number = {8}, pages = {1572--1597}, doi = {10.1177/13548166241305694}, url = {1917996}, language = {eng}, publisher = {Sage Publications}, keywords = {covid-19; limited-service restaurants; profit inefficiency; restaurant industry; stochastic frontier analysis}, abstract = {This study investigates the drivers of profit inefficiency in the restaurant industry. Assuming that restaurants operate under monopolistic competition, we first present a characterization of the factors that explain restaurants’ departure from the profit frontier, focusing on the role of business experience, number of outlets, service model, restaurant typology, and COVID-19 shock. Based on Stochastic Frontier Analysis, we estimate how these factors explain the differences in profit inefficiency across firms using a panel dataset of 4128 restaurants in Sweden in the period 2017–2021. We find that the average level of profit efficiency is low (46%). Inefficiency increases with years in operation and is significantly higher among limited-service restaurants and single-outlet firms. Interestingly, no significant difference in profit inefficiency is detected during the COVID-19 pandemic. Our findings provide valuable insights for profit efficiency management.}, issn = {1354-8166} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_volgstenulrik_2025_5, title = {What have I done? On Artistic Freedom, Authenticity and the Identification of Music, from Movable Type Print to Copyright and Digital Fingerprints}, author = {Volgsten, Ulrik and Eriksson, Maria}, year = {2025}, pages = {67--83}, doi = {10.1007/978-3-031-66363-5_6}, url = {1990278}, language = {eng}, publisher = {Palgrave Macmillan}, keywords = {copyright; fingerprints; creativity}, abstract = {In this chapter we explore how techniques used for musical identification may shape the ways in which people – composers, producers and listeners – hear sounds as music. Our thesis is that for more than three centuries, manual and automated techniques used for identifying music have played a central role in efforts to safeguard rights to music and to define what counts as music in the first place. In other words, musical identification techniques are not just tools for managing music rights and finances but are also vehicles for establishing and safeguarding culturally specific ideas and boundaries concerning music itself. To test and explore this thesis, we focus on three legal issues that arose in 1817, 2002 and 2017, concerning the authenticity and originality of musical works. Central to our investigation is the realization that distinguishing one piece of music from another is key to the protection of copyright and that the principles that underlie such distinctions define what a composer does, what a producer produces and what listeners listen to. In other words, music identification techniques both shape and delimit musical possibilities.}, file = {https://oru.diva-portal.org/smash/get/diva2:1990278/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_johanssonwilnevelina_2025_18, title = {What Incels Learned From Feminism}, author = {Johansson Wilén, Evelina}, year = {2025}, journal = {Jacobin}, number = {December 12}, url = {2021380}, language = {eng}, publisher = {Jacobin Press}, issn = {2470-6930} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hugeliuskarin_2025_2, title = {What is Disaster Readiness Among Health Care Professionals? A Systematic Integrative Review Study}, author = {Hugelius, Karin and Harada, Nahoko}, year = {2025}, journal = {Disaster Medicine and Public Health Preparedness}, volume = {19}, doi = {10.1017/dmp.2025.58}, url = {1946262}, language = {eng}, publisher = {Cambridges Institutes Press}, keywords = {disaster; disaster preparedness; disaster readiness; mental preparedness}, abstract = {Objective: This study aimed to explore the meaning of disaster readiness among health care professionals.Methods: A systematic, integrative literature review was conducted on PubMed, Chinal plus with full text, Web of Science, PsychInfo, and Scopus. Quality appraisal was conducted using the CASP checklists.Results: A total of 22 scientific articles were included. Disaster readiness, from the perspectives of health care professionals, was defined as having sufficient skills and confidence to respond, having access to the necessary equipment, being able to adapt to the changing environment and organizational structure, and being willing to serve in a disaster.Conclusions: Disaster readiness is more than being prepared. Disaster readiness means moving beyond technical skills and knowledges to include personal mental preparedness and a willingness to confront the risks and take necessary precautions to stay safe and resilient in the efforts to help others. To enhance disaster readiness, preparations should include introducing elements that touch the soul, providing moral and personal motivation to serve in a disaster, and initiating thoughts on what such deployments or situations could be like for those affected as well as for health care professionals. How to enhance such trainings and develop effective training methods must be a focus for future studies.}, issn = {1935-7893} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_argrenrigmor_2025_2, title = {What militaries need to know about data protection and the right to digital privacy/private life}, author = {Argren, Rigmor}, year = {2025}, journal = {International Review of the Red Cross}, volume = {107}, number = {928}, pages = {2--18}, doi = {10.1017/S1816383124000353}, url = {1906355}, language = {eng}, publisher = {Cambridge University Press}, keywords = {armed conflict; right to data protection; right to digital privacy/private life; inherent limitations}, abstract = {With the advent of socio-technical systems that gather and process personal data, the capacity to identify and even locate people in an automated fashion has dramatically increased. This article discusses what militaries need to know about data protection and the right to digital privacy/private life when personal data is processed. The focus in this discussion is on sensitive data that makes individuals identifiable. It is here argued that the right to data protection and the right to digital privacy/private life are distinctive and separate rights and should be treated as such, despite some overlaps. Although the law of armed conflict approaches processing of sensitive data in a topical manner, it remains firm on the delimitation between what is permissible and what becomes unlawful when it comes to processing data. This article illustrates that elements of both data protection and protection of the right to privacy/private life can be traced in the law of armed conflict. In fact, both rights remain distinctive also in times of armed conflict and must be separately protected through obligations of result as well as obligations of conduct.}, issn = {1816-3831} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_nishimurarimei_2025, title = {WHAT RATES OF CORRECTION DOSES ARE FOLLOWED BY HYPOGLYCAEMIA AND DO THEY VARY BETWEEN PEOPLE LIVING WITH DIABETES USING A CONNECTED INSULIN PEN?}, author = {Nishimura, Rimei and Winhofer, Yvonne and Jensen, Maika Lindkvist and Kaas, Anne and Knudsen, Nikoline Nygård and Jendle, Johan}, year = {2025}, journal = {Diabetes Technology & Therapeutics}, volume = {27}, number = {Suppl. 2}, pages = {E370--E370}, url = {2038364}, language = {eng}, publisher = {Mary Ann Liebert}, abstract = {Background and Aims: Individuals living with diabetes may use an additional bolus insulin dose to correct elevated glucose levels. We investigated the real-world rate of correction doses followed by hypoglycaemia.Methods: Data were collected from 18,769 adults with diabetes who were using a continuous glucose monitoring device and started administering bolus insulin using a smart insulin pen. A correction dose followed by hypoglycaemia was defined as an injection 15–120 minutes after the previous bolus dose and hypoglycaemia (<70 mg/dL for ≥15 minutes) occurring during the next 3 hours. Rates of correction doses followed by hypoglycaemia during the first month and over time following smart pen initiation were examined by age and smart pen engagement (assessed by frequency of data uploads to app).Results: Rates of correction doses followed by hypoglycaemia were higher in individuals aged 18–30 years, and lower in periods with increased smart pen engagement (Figure). For individuals aged 18–30 years, a significant decrease in the rate of correction doses followed by hypoglycaemia (−2.94%; 95% CI: −5.10, −0.72) was observed six months after smart pen initiation.Image (.png) is missing or otherwise invalid.Conclusions: The rate of correction doses followed by hypoglycaemia was inversely correlated with both age and smart pen engagement. However, the higher rate initially seen in younger individuals had improved by six months after smart pen initiation. Smart pen engagement could help to optimise dosing behaviour and reduce the rate of correction doses leading to hypoglycaemia.Acknowledgements: Medical writing support, funded by Novo Nordisk, was provided by Oxford PharmaGenesis, UK.}, issn = {1520-9156} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_kolkowskaella_2025_2, title = {What Seniors Need vs What Providers Deliver : A Cross-Country Perspective on Value (Mis)Alignment in Digital Transformation of Elderly Care in Poland and Sweden}, author = {Kolkowska, Ella and Soja, Ewa and Soja, Piotr and Kanclerz, Jakub and Balsamski, Bartlomiej}, year = {2025}, doi = {10.62036/ISD.2025.120}, url = {2032353}, language = {eng}, publisher = {International Conference on Information Systems Development}, keywords = {elderly care; digital transformation; value-based objectives; providers}, abstract = {This explorative study examined how technology providers are meeting seniors’ expectations for developing ICT solutions enabling digital transformation of elderly care in two contrasting socioeconomic settings: Poland and Sweden. To this end, we have analyzed the characteristics emphasized as important by technology providers on their websites and compared these factors with seniors’ needs identified in previous research. Our preliminary findings suggest that technology providers in Poland and Sweden fall short to fully meet the diversity of seniors’ needs or address their expectations. In this respect, it appears that technology providers focus mainly on those needs of seniors that are mos strongly recognized and unmet in the context of the prevailing socio-economic conditions of a given country.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_wangqi_2025_1, title = {What we learn from using mass balance approach and oxidative conversion : a case study on PFAS contaminated soil samples}, author = {Wang, Qi and van Hees, Patrick and Karlsson, Patrik and Jiao, Enmiao and Filipovic, Marko and Lam, Paul K. S. and Yeung, Leo W. Y.}, year = {2025}, journal = {Environmental Pollution}, volume = {376}, doi = {10.1016/j.envpol.2025.126420}, url = {1958441}, language = {eng}, publisher = {Springer}, keywords = {pfas precursor; the total fluorine (tf); combustion ion chromatography; extractable organofluorine (eof); nontarget and suspect screening; total oxidizable precursor (top) assay; ultra-short chains pfas; unknown pfas}, abstract = {Per- and polyfluoroalkyl substances (PFAS) are a large family of synthetic fluorinated chemicals. Studies using multiple analytical approaches to evaluate PFAS-contaminated soils are still limited, potentially leading to an underestimation of PFAS pollution. This study introduced a stepwise analytical workflow for a comprehensive assessment of organofluorine, integrating total fluorine (TF) determination, extractable organofluorine (EOF) analysis, PFAS target analysis, and PFAS precursor oxidative conversion assay. The workflow was applied to ten field soil samples collected from aqueous film-forming foam (AFFF)-contaminated sites. The sum target PFAS concentration (∑PFAS) ranged from 51.8 to 232000 ng/g dry weight. Perfluorooctanesulfonic acid was the predominant PFAS, accounting for 13% to 82% (mean value: 53%) of the ∑PFAS. Target PFAS accounted for 1% to 80% of the EOF in the soil samples, and the integration of oxidative conversion revealed additional EOF contributions ranging from 0% to 31%. However, a considerable proportion (20% to 94%) of unknown organofluorine (UOF) still persists after combining targeted PFAS analysis and oxidative conversion, likely due to non-oxidizable PFAS, incomplete conversion of unknown PFAS precursors, and persistence of ultra-short chain PFAS post oxidative conversion. In addition, a significant positive correlation was observed between oxidative conversion and EOF results, but not with PFAS target analysis, suggesting that oxidative conversion may better represent the organofluorine burden in AFFF-impacted soils. Our findings indicate that TF analysis is unsuitable for tracing PFAS contamination in soils. Instead, combining oxidative conversion with routine PFAS target analysis is recommended to comprehensively assess PFAS contamination in soils.}, issn = {0269-7491} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ohaganlaurenalex_2025_10, title = {“When Jimi Hendrix was Asked..” : A Netnographic Study of a Contemporary Legend About Rory Gallagher}, author = {O’Hagan, Lauren Alex}, year = {2025}, journal = {Rock Music Studies}, doi = {10.1080/19401159.2025.2564609}, url = {2028267}, language = {eng}, publisher = {Routledge}, keywords = {contemporary legends; fandom; jimi hendrix; mythologization; netnography; rory gallagher}, abstract = {This paper examines the contemporary legend surrounding the quotation “Ask Rory Gallagher,” allegedly spoken by Jimi Hendrix when asked how it felt to be the world's greatest guitarist. Long debated within Gallagher’s fan community, the statement's origins and authenticity remain uncertain. Using a netnographic approach combining digital archival research and social media observation, the study traces the legend's sources, circulation, and reception. It also reflects on why the legend remains contentious, particularly in relation to Gallagher’s musical legacy and Irish national identity. Overall, the study advances understanding of digital folklore, myth-making, and the cultural dynamics of fandom. }, issn = {1940-1159} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_alsarvejenny_2025, title = {When men become fathers, women become project leaders : Swedish parenting practices over time}, author = {Alsarve, Jenny and Glatz, Terese}, year = {2025}, journal = {Journal of Family Studies}, volume = {31}, number = {5}, pages = {884--905}, doi = {10.1080/13229400.2025.2481113}, url = {1949965}, language = {eng}, publisher = {Routledge}, keywords = {division of labour; gender; cognitive labour; parenthood; care}, abstract = {The gendered division of housework and care has long been a key topic in family research. In this qualitative study, the aim is to deepen the knowledge of parents' division of labour by exploring how their division of housework and care changes over time. We are specifically interested in how the cognitive labour emerges and develops as couples transition into parenthood and the following years: (1) How is the division of labour among couples modified, maintained, and/or challenged during the transition to parenthood, and as their children go from early childhood to school-age? and (2) how does cognitive labour, and the different aspects of such labour, emerge over time among studied parental couples? Drawing on theories of gender, care and cognitive labour, a key finding concerns the gradual emergence of the female planning responsibility, a central aspect of cognitive labour. Although the parents wanted to share the care and housework equally, it was still the mothers who mainly carried this invisible responsibility. The findings thus suggest that even when couples are reflecting and trying actively to avoid falling into a traditional gendered division, the new parenthood puts these norms and values to a test.}, issn = {1322-9400} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_westerholtmarc_2025_2, title = {When more is less : follow-up on the hook effect in Borrelia serology}, author = {Westerholt, Marc and Ocias, Lukas}, year = {2025}, journal = {European Journal of Clinical Microbiology and Infectious Diseases}, doi = {10.1007/s10096-025-05323-1}, url = {2008922}, language = {eng}, publisher = {Springer}, issn = {0934-9723} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_westerholtmarc_2025_3, title = {When more is less : follow-up on the hook effect in Borrelia serology}, author = {Westerholt, Marc and Ocias, Lukas}, year = {2025}, journal = {European Journal of Clinical Microbiology and Infectious Diseases}, doi = {10.1007/s10096-025-05323-1}, url = {2008650}, language = {eng}, publisher = {Springer}, issn = {0934-9723} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_abdelzadehali_2025, title = {When Standby Citizens Step In : The Role of Institutional Factors in Triggering Youth Political Participation}, author = {Abdelzadeh, Ali and Lundberg, Erik and Amnå, Erik}, year = {2025}, journal = {Young - Nordic Journal of Youth Research}, doi = {10.1177/11033088251394905}, url = {2019965}, language = {eng}, publisher = {Sage Publications}, keywords = {standby citizens; political participation; civic engagement; government performance; political passivity; longitudinal data}, abstract = {Accusations of political passivity are often directed towards citizens, especially the youth. This study challenges the prevailing narrative by exploring the latent dimensions of political participation, and in particular the role of 'standby citizens', that is, those who are politically interested yet non-participatory. We propose that these individuals engage in behavioural activism when they perceive governmental actions as failing to meet their needs and demands. To test this hypothesis, we utilized a longitudinal sample of adolescents, classifying them into four distinct groups: active, standby, unengaged and other. We examined the transitions between these groups over time. Our findings indicate that standby adolescents are significantly more likely to shift towards active participation and less likely to become completely disengaged. Specifically, those who moved from standby to active status reported a significant decline in satisfaction with government performance over time, while their counterparts who remained in the standby mode did not show such changes.}, issn = {1103-3088} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_swahnjohan_2025_1, title = {When the music stops : Crossmodal effects of sounds on taste do not explain changes in liking}, author = {Swahn, Johan and Nilsen, Asgeir and Baptista, Iuri}, year = {2025}, journal = {Food Quality and Preference}, volume = {131}, doi = {10.1016/j.foodqual.2025.105576}, url = {1961485}, language = {eng}, publisher = {Elsevier}, keywords = {sensory analysis; multisensory; ambience; consumer; chocolate}, abstract = {Environmental sounds influence taste perception and liking of food because eating is a multisensory experience that integrates all senses. The present study investigated how a dark chocolate ganache with two different levels of added sugar was perceived when sounds corresponding to sweet and bitter tastes were played, as well as no sound. A total of 515 participants rated the balance of sweet and bitter tastes using just-about-right (JAR) and the overall liking using a hedonic scale. Results show that the bitter sound increased the perception of bitterness of both ganache and the sweet sound increased the perception of sweetness of the higher-sugar ganache. Although not always significant, both sounds had positive effects on liking, even when they exacerbated tastes already in excess and pushed them further from the ideal. These results indicate that the sounds were effective in influencing sensory perceptions of ganache, but their effects on liking did not come from taste improvement, most likely from sensory-emotional stimulation. Together with previous studies that found significant effects of sound in perception of taste, aroma, and texture, but not in liking, this study adds evidence on the importance of environmental sounds in eating contexts and propose that crossmodal effects of sound and liking are independent processes.}, issn = {0950-3293} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kjelsrudaasslisbeth_2025, title = {"Where are we on the Road Towards Family-focused Practice in Mental Healthcare?" : Perspectives from a Swedish/Norwegian Research Collaborative}, author = {Kjelsrud Aass, Lisbeth and Weimand, Bente and Ewertzon, Mats and Skundberg-Kletthagen, Hege and Lindholm, Ingrid and Larsen Moen, Øyfrid and Schröder, Agneta and Andfossen, Nina Beate}, year = {2025}, journal = {Community mental health journal}, doi = {10.1007/s10597-025-01499-0}, url = {1991959}, language = {eng}, publisher = {Springer}, keywords = {caring roles; family-focused practice; mental health; volunteers}, abstract = {As a Norwegian/Swedish research network based on a family-focused practice in mental healthcare, we recognise the need to highlight this approach for the future quality and sustainability of the care and services provided. The role of family members in caring for individuals with mental health conditions is situational and diverse, encompassing several support areas such as emotional support, continuation of social and living skills, economic assistance, and monitoring for signs of illness and relapse prevention. In this context, volunteers have also been encouraged to contribute as partners in the support and follow-up of individuals with mental health issues. Although mental health services were primarily hospital-based in the past, there has been a shift in recent decades towards community-based care with support from specialist services. The aim has been to foster a respectful partnership between patients, families, and professionals, including a commitment to increasing family involvement and providing greater support to family members. Despite the recommendation for family-focused practice, we believe that health professionals still prioritise their alliance with the patient as their foremost responsibility. In this article, we advocate for an enhanced emphasis on family-focused approaches and underscore the importance of utilising knowledge-based family-focused practice models.}, issn = {0010-3853} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_unemomagnus_2025_1, title = {WHO global gonococcal antimicrobial surveillance programmes, 2019-22 : a retrospective observational study}, author = {Unemo, Magnus and Lahra, Monica M. and Cole, Michelle J. and Marcano Zamora, Daniel and Jacobsson, Susanne and Galarza, Patricia and Martin, Irene and Kreisel, Kristen M. and Galas, Marcelo and Bertagnolio, Silvia and Ramon-Pardo, Pilar and Maatouk, Ismael and Wi, Teodora}, year = {2025}, journal = {The Lancet Microbe}, volume = {6}, number = {10}, doi = {10.1016/j.lanmic.2025.101181}, url = {2001988}, language = {eng}, publisher = {Elsevier}, abstract = {BACKGROUND: Gonorrhoea and gonococcal antimicrobial resistance (AMR) remain global public health concerns, and enhanced quality-assured global surveillance of gonococcal AMR is imperative to inform management guidelines and public health policies. We aimed to describe the results of surveillance of gonococcal AMR conducted globally by WHO and discuss the actions needed to retain our ability to treat gonorrhoea.METHODS: In this retrospective observational study, we present gonococcal AMR data reported to WHO by 77 countries between Jan 1, 2019, and Dec 31, 2022. Gonococcal isolates were tested for minimum inhibitory concentrations of one to four key antimicrobials (ceftriaxone, cefixime, azithromycin, and ciprofloxacin) in each country. We used breakpoints for resistance and decreased susceptibility to antimicrobials from the European Committee on Antimicrobial Susceptibility Testing or Clinical Laboratory and Standards Institute.FINDINGS: 29 (39%) of 75 participating countries reported at least one isolate with resistance or decreased susceptibility to ceftriaxone, 28 (50%) of 56 reported resistance or decreased susceptibility to cefixime, 58 (88%) of 66 reported resistance to azithromycin, and 74 (99%) of 75 reported resistance to ciprofloxacin. Globally, azithromycin resistance is increasing, as is resistance or decreased susceptibility to ceftriaxone and cefixime, especially in the WHO Western Pacific region. Resistance to ciprofloxacin remained very high globally. Since 2017-18, the numbers of reporting countries, examined isolates, and resistant isolates have increased. However, surveillance levels remain inadequate in central America and the Caribbean, eastern Europe, and the WHO African, Eastern Mediterranean, and South-East Asia regions.INTERPRETATION: Global AMR surveillance conducted by WHO is expanding and, in selected countries, improving through standardisation and quality assurance, as well as implementation of extragenital sampling, test of cure, and whole-genome sequencing. This approach provides evidence-based data for management guidelines and public health policies. Improvements in prevention, early diagnosis, treatment of patients and their contacts, surveillance (of infection rates, AMR, treatment failures, and antimicrobial use), and antimicrobial stewardship are essential. WHO supports this work through several global action plans on AMR, new global gonorrhoea treatment recommendations, surveillance, and research.}, issn = {2666-5247} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gunnarssonlena_2025_2, title = {Who Holds the Power? Gendered Experiences of Involuntary Singlehood in the Age of Online Dating}, author = {Gunnarsson, Lena and Johansson Wilén, Evelina and Wemrell, Maria}, year = {2025}, journal = {Sociological inquiry}, doi = {10.1111/soin.70037}, url = {2010990}, language = {eng}, publisher = {John Wiley & Sons}, keywords = {emotional labor; gender; gender-based violence; heterosexuality; incels; involuntary celibacy; involuntary singlehood; manosphere; online dating; singlehood}, abstract = {Although singlehood is a desired lifestyle for an increasing number of heterosexual women and men, many are involuntarily single, struggling to find a partner. Meanwhile, popular debates about dating are sharply polarized along gendered lines. While “incels” see themselves as victims on a dating market ruled by women, relatively mainstreamed feminist sensibilities frame heterosexuality as marked by men's power. This article investigates how Swedish heterosexual long-term involuntary singles experience and make sense of the gendered conditions of contemporary dating. Addressing the tendency in online dating for women to receive significantly more attention and responses from men than men do from women, we reveal substantial tensions in how the participants understand this gendered dynamic, with the men tending to interpret it as a matter of women's power, while the women's experiences and perspectives complicate this notion considerably. By identifying some key mechanisms involved in producing these divergences in women's and men's perspectives, our analysis deepens understandings of contemporary gendered conflicts around love, while also shedding light on the antifeminist dynamics of the incel community.}, issn = {0038-0245} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_tornhamreelsa_2025, title = {Who is at risk of long-term subjective memory impairment after electroconvulsive therapy?}, author = {Tornhamre, Elsa and Hammar, Åsa and Nordanskog, Pia and Nordenskjöld, Axel}, year = {2025}, journal = {Journal of Affective Disorders}, volume = {372}, pages = {324--332}, doi = {10.1016/j.jad.2024.12.028}, url = {1919581}, language = {eng}, publisher = {Elsevier}, keywords = {depression; electroconvulsive therapy; long-term; memory; risk factors}, abstract = {BACKGROUND: Electroconvulsive therapy (ECT) is an effective treatment for depression with potential transient cognitive side effects. However, subjective memory impairment can extend over a long period after ECT.OBJECTIVES: This study aimed to assess potential risk factors for long-term subjective memory impairment 6 months after ECT and to explore if the associations are mediated by depressive symptoms.METHODS: This registry-based study used the Swedish National Quality Register for ECT and other national registers. Long-term subjective memory worsening was defined as a minimum 2-step worsening on the memory item from the comprehensive psychopathological rating scale (CPRS-M) from before ECT to 6 months after ECT. Changes on the scale were also analyzed in continuous models. Statistical methods used were logistic regression and linear regression analyses in univariable and multivariable models.RESULTS: The study population consisted of 1498 patients. Subjective memory worsening occurred in 25.2 % of the population. Long-term subjective memory worsening was associated with more depressive symptoms and lower education levels. No association could be found related to ECT technical factors. The associations between age and psychiatric comorbidities with subjective memory worsening were mediated by depressive symptoms.CONCLUSION: Patients can be informed that depressive symptoms are one of the biggest contributing factors to long-term subjective memory impairment after ECT. A successful treatment is therefore important to minimize the long-term experience of memory deficits. The number of sessions or ECT technical factors do not seem to be associated with long-term subjective memory impairment.}, issn = {0165-0327} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_karlssonjenny_2025, title = {Who is Navigating this Ship? A Qualitative Interview Study of Nursing Staff's Experiences of Implementing Safewards in a Forensic Mental Health Clinic}, author = {Karlsson, Jenny and Anttonen, Siina and Kjellin, Lars and Pelto-Piri, Veikko and Björkdahl, Anna}, year = {2025}, journal = {International Journal of Forensic Mental Health}, volume = {24}, number = {2}, pages = {181--191}, doi = {10.1177/14999013251332954}, url = {1956511}, language = {eng}, publisher = {Sage Publications}, keywords = {qualitative research; forensic mental health; implementation; safewards; nursing staff experiences}, abstract = {The need to reduce restrictive practices in forensic mental health settings reflects a broader shift from traditional authoritarian and custodial approaches toward a more recovery-oriented ward environment. Safewards is an evidence-based model of care with ten interventions to reduce conflict and containment, focusing on social inclusion, communication skills, and patient support in stressful situations. This study aimed to describe the experiences of nursing staff with the implementation of Safewards in a Swedish forensic mental health clinic. Nine nurses participated in two focus group interviews. Using qualitative content analysis, three main themes were identified: Calling for leadership and resources, Striving for engagement, and Fostering awareness of nursing practice. Each main theme included two sub-themes. Participants described a general lack of leadership that left them feeling lost and uncertain during the implementation process. Descriptions related to preparation and training, hesitance to include patients in the implementation, and concerns about the fit of Safewards with existing clinical practices. Despite these challenges, the nurses were overall positive about Safewards, viewing the model as a step towards a recovery-oriented approach. The results support the implementation of Safewards Secure, a complement developed to the original Safewards model, tailored to the context of forensic mental health settings.}, issn = {1499-9013} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_gustafssonkarinm_2025_2, title = {Whom to call as an expert on the social dimension of transformativechange in global environmental assessments?}, author = {Gustafsson, Karin M}, year = {2025}, journal = {Environmental Sociology}, doi = {10.1080/23251042.2025.2552498}, url = {1993001}, language = {eng}, publisher = {Taylor & Francis}, keywords = {social knowledge; expertise; ipcc; ipbes; expert jurisdictions; transformative change}, abstract = {As the social dimension and hybridity of environmental problems have become clear, and transformative changes of our societies have been presented as the solution to these problems, the question has arisen of whom expert organizations such as IPCC and IPBES should continue to call on to remain credible, relevant and legitimate. To explore and explain different dimensions of social expertise, this paper formulates and problematizes three potential answers to the question of whom to call upon as an expert on the social. First, to expand the jurisdiction of natural science expertise. Second, to acknowledge the jurisdiction of social science expertise. Third, to embrace the jurisdiction of transdisciplinary expertise. With these answers, the paper explores different perspectives on how to understand social expertise, unveils jurisdictional disputes that are taking place over whom may explain the social dimensions of environmental problems and transformative change, and argues for the importance of a greater and reflexive understanding of different forms of expertise among the actors that carry the responsibility to call on experts on transformative change.}, issn = {2325-1042} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_bostrmmagnus_2025_2, title = {Why and how lifestyle change to reduced consumption is an active part of the emerging sustainability transformation}, author = {Boström, Magnus and Callmer, Åsa}, year = {2025}, journal = {Current Sociology}, doi = {10.1177/00113921251381810}, url = {2016220}, language = {eng}, publisher = {Sage Publications}, keywords = {agency-structure; overconsumption; sociology of consumption; sufficiency; transformative change; agence et structure; changement transformateur; sociologie de la consommation; suffisance; surconsommation; agencia-estructura; cambio transformador; sobreconsumo; sociolog & iacute; a del consumo; suficiencia}, abstract = {Humanity exceeds or threatens to exceed the planetary boundaries. The problem of unsustainable lifestyles in affluent contexts is, therefore, increasingly up for debate. Despite growing attention, this theoretical article argues that there is, in science as well as policy, a lack of recognition of the problem of unsustainable volumes of consumption, and institutional failure to address radical lifestyle change. While there is broad consensus about the societal need to address consumption patterns, controversies remain about the need to address the volumes of consumption. The article takes this debate as a point of departure and focuses specifically on a tendency in critical consumption studies within sociology and related disciplines: the neglect of the larger transformative potential embedded in lifestyle change at the grassroot level. It contributes with six arguments for why it is necessary to consider individual lifestyle changes, and particularly consumption reduction, as an active part of the greater transformation needed to make our societies fit within the planetary boundaries. It also contributes by highlighting five critical aspects on how such bottom-up change can contribute to transformative change. It thus contributes to the sociological and interdisciplinary theoretical, empirical, and normative discussion around the interplay between lifestyle change and sustainability transformation.}, issn = {0011-3921} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_barkerdean_2025_1, title = {Why assessment in physical education is still problematic : A critical interpretive synthesis of physical education assessment literature}, author = {Barker, Dean and Tolgfors, Björn and Caldeborg, Annica}, year = {2025}, journal = {European Physical Education Review}, doi = {10.1177/1356336x251374556}, url = {1998899}, language = {eng}, publisher = {Sage Publications}, keywords = {assessment for learning; assessment for accountability; formative assessment; summative assessment; instructional alignment}, abstract = {Assessment has received considerable attention from researchers in the field of physical education (PE). Many scholars have examined either formative assessment or summative assessment, with their focus leading to different questions and considerations. In this review, we examine howand why both formative and summative assessment have been problematized by PE scholars. Through a critical interpretive synthesis, we identify: (1) the main problems associated with both forms of assessment identified between 1999 and 2024, and (2) the solutions that scholars have offered in response to these problems. Problems with summative assessment center on teachers’ use of personal and internalized criteria, students’ negative experiences, and the guidance that policy provides teachers for enacting assessment. Solutions revolve around the provision of continuing professional development, improving initial teacher education, and ensuring that policy clearly delineates how assessment should be conducted. Problems with formative assessment revolve around teachers’ and students’ unfamiliarity with formative assessment practices and their lack of competence in using assessment strategies. Recommended solutions center on accepting that formative assessment has advantages and disadvantages, increasing students’ participation in assessment practices, and improving teachers’ assessment proficiency. We consider the extent to which assessment scholarship can contribute to change in assessment practices in PE, developing the thesis that several factors constrain the ability of research to lead to improvements. We conclude with alternative approaches that scholars might use to reimagine research on formative and summative assessment.}, issn = {1356-336X}, file = {https://oru.diva-portal.org/smash/get/diva2:1998899/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_ljungqvistolle_2025_2, title = {Why do ERAS?}, author = {Ljungqvist, Olle and Gianotti, Luca}, year = {2025}, journal = {Minerva Anestesiologica}, volume = {91}, number = {5}, pages = {395--396}, doi = {10.23736/S0375-9393.25.18840-8}, url = {1938673}, language = {eng}, publisher = {Edizioni Minerva Medica}, issn = {0375-9393} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_anderssonjrnberglinda_2025, title = {Willingness to pay for private and public traffic safety improvements : the importance of the underlying good}, author = {Andersson Järnberg, Linda and Andrén, Daniela and Hultkrantz, Lars and Rutström, Elisabet and Vimefall, Elin}, year = {2025}, journal = {Applied Economics}, volume = {57}, number = {42}, pages = {6636--6649}, doi = {10.1080/00036846.2024.2386844}, url = {1888471}, language = {eng}, publisher = {Routledge}, keywords = {willingness to pay; traffic safety; private good; public good; cyclists and pedestrians}, abstract = {Findings in the traffic safety literature suggest that people value traffic risk reductions less when framed as a public good (e.g. infrastructure improvements) compared to when framed as a private good (e.g. personal safety equipment). This study contributes to this literature by reporting empirical evidence for the importance of controlling for the attributes of the goods used in such valuations. We focus on risks faced by vulnerable road users such as cyclists and pedestrians and compare valuations across private and public goods that vary in their attributes. When the goods are of an identical nature, we find no significant difference in valuations, resolving the controversy in previous findings. We find significant effects on valuations from using private or public provision, from offering the good as voluntary or mandated in use, and from changing the framing of the good between the private and the public versions. This adds further weight to the importance of controlling for many attributes.}, issn = {0003-6846} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_andrndaniela_2025_8, title = {Willingness to Pay for Traffic Safety : Driven by Life Satisfaction but Not Steered by Accident Experience}, author = {Andrén, Daniela}, year = {2025}, url = {2003692}, language = {eng}, abstract = {Background: Despite progress in traffic safety, traffic-related fatalities are projected to become the fifth most common cause of death worldwide by 2030, emphasizing the need for robust infrastructure, safer vehicles, and simplified traffic regulations that address individuals’ behavior and well-being. While earlier studies have explored the impacts of accident experiences on well-being and safety preferences, the link between life satisfaction and willingness to pay (WTP) for traffic safety remains underexplored.Aim of the Study: This study examines how WTP for traffic safety varies across intervention types, their framing as public or private goods, and the influence of life satisfaction. It also evaluates whether accident experiences affect life satisfaction or directly influence WTP, and investigates how trust and familiarity with safety measures shape WTP.Data and Methods: Using a representative Swedish sample, we analyzed relationships between life satisfaction, accident experiences, and WTP for safety measures for pedestrians and cyclists. Interval regression was applied to account for censored WTP responses. Respondents evaluated familiar interventions (e.g., anti-slip treatments, better lighting) and less familiar, high-tech solutions (e.g., sensors, mobile apps).Results: Traffic accident experience showed no significant effect on life satisfaction, consistent with hedonic adaptation. However, life satisfaction significantly increased WTP. Familiar interventions yielded higher WTP across public and private measures. For unfamiliar, technology-based solutions, WTP was higher for public interventions, likely reflecting trust in public authorities.Conclusions: Our findings highlight the importance of life satisfaction and familiarity in shaping WTP for traffic safety. Unfamiliar interventions based on new technologies should be carefully introduced to foster public trust and acceptance.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_stormanelin_2025, title = {Work identities and changed work roles in times of crisis : a study of hospitality workers during restructuring}, author = {Storman, Elin and Thulemark, Maria and Heldt Cassel, Susanna}, year = {2025}, journal = {Scandinavian Journal of Hospitality and Tourism}, volume = {25}, number = {2}, pages = {188--204}, doi = {10.1080/15022250.2024.2446807}, url = {1928287}, language = {eng}, publisher = {Routledge}, keywords = {covid-19 pandemic; hotel work; job security; organization of work; work identity}, abstract = {This paper examines how restructuring of hotel work affects work identities and attractiveness of work, based on 29 semi-structured interviews with staff at three hotels in Sweden. The external crisis - the COVID-19 pandemic - played a significant role in justifying restructuring, shifting power dynamics in favor of employers and enabling change. The results of this study indicate that restructuring led to vague role descriptions, which affected work identity, job security and attractiveness of work. The study highlights the tension between job security and preservation of work identity, showing that while changes in work roles can provide job security, they also alter the context upon which work identity is built. This duality has created dilemmas for employees, forcing them to accept changes in work identity or jeopardizing job security. The study also emphasizes how restructuring risk affecting career opportunities, work roles, hierarchical levels and turnover intentions.}, issn = {1502-2250} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_andrndaniela_2025_9, title = {Work Integrated Social Enterprises : Balancing Social Impact and Economic Sustainability through Governance and Policy Support}, author = {Andrén, Daniela and Kremel, Anna}, year = {2025}, url = {2003684}, language = {eng}, publisher = {Örebro University, School of Business}, keywords = {work integrated social enterprises; social inclusion; entrepreneurship; municipal support}, abstract = {Work Integrated Social Enterprises (WISEs) have emerged as a powerful and dynamic force in redefining the established norms while enhancing sustainability, promoting integration and nurturing more inclusive working societies by addressing employment barriers for marginalized groups. Using data from semi-structured interviews with WISEs in a mid-sized Swedish municipality, this article’s findings reveal the challenge they face, such as financial sustainability, the need for formal organizational structures, and societal prejudices. The findings highlight WISEs’ strategies for balancing economic stability with their social mission and emphasize the pivotal role of municipal and regional governance in supporting their operations. Targeted policy support in areas like management, human resources, and financial backing is essential to ensure WISEs’ survival and long-term success.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_andrndaniela_2025_10, title = {Work Integration Social Enterprises : Entrepreneurship at the Intersection of Social Impact and Economic Sustainability – Insights from Sweden}, author = {Andrén, Daniela}, year = {2025}, url = {2003697}, language = {eng} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_ehnmattias_2025, title = {Work-Life Balance in People with Usher Syndrome}, author = {Ehn, Mattias}, year = {2025}, pages = {191--203}, doi = {10.1093/oso/9780192887221.003.0018}, url = {2029316}, language = {eng}, publisher = {Oxford University Press}, keywords = {deafblind; health; usher syndrome; work; work-life}, abstract = {People with deafblindness are often described in terms of vulnerability or poor health outcomes, and not many studies have focused on aspects of coping and resilience. Work-life has been found to fulfill fundamental human needs in the general population, and in this chapter, I will discuss how work-life can fulfill important psychological needs and how it can be related to health and well-being in a group of adults with deafblindness due to Usher syndrome. The chapter discusses findings using the Meikirch biopsychosocial health model and is mainly based on findings that have previously been reported in my PhD thesis.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_vikingmagnus_2025, title = {Workplace violence in the ambulance service from the offender’s perspective : a qualitative study using trial transcripts}, author = {Viking, Magnus and Hugelius, Karin and Höglund, Erik and Kurland, Lisa}, year = {2025}, journal = {BMC Emergency Medicine}, volume = {25}, number = {1}, doi = {10.1186/s12873-025-01232-w}, url = {1958627}, language = {eng}, publisher = {BioMed Central (BMC)}, keywords = {aggression; ambulance; ambulance nurse; ambulance service; offender; qualitative; trial transcripts; workplace violence}, abstract = {Background: Workplace violence is a widely recognised problem within the ambulance service context. The causes of workplace violence have often been attributed to patient- or situation-related risk factors. However, there is a lack of research on workplace violence from the offender's perspective.Aim: To explore workplace violence directed toward ambulance services from the offender's perspective.Methods: An explorative qualitative study was conducted using inductive thematic analysis of trial transcripts from cases tried in court between 2013 and 2023. Plaintiffs in these cases were ambulance personnel or the ambulance service itself. Offenders were those convicted of committing or attempting any of the following acts: threats, theft, assault, molestation or murder.Results: Twenty-three trial transcripts were analysed, and four themes were found: (I) the offender was misunderstood, which included communication problems and other misunderstandings; (II) the offender was disrespected, which described perceived unprofessional behaviour and unpleasant or painful treatment by ambulance personnel; (III) the offender was vulnerable, which described the state of the offender (i.e., being under the influence of alcohol or drugs); and (IV) the offender had unmet expectations, which included perceived unreasonable waiting time and conflicting expectations of ambulance care.Conclusion: The analysis of trial transcripts revealed four themes from the offender perspective: feelings of being misunderstood, disrespected, vulnerable, and having unmet expectations. It is important to view these results critically, as they are based on trial transcripts in which the offender was found guilty of a crime and may have been attempting to defend his or her actions during the trial. Despite this caveat, healthcare professionals need also to recognise that their behaviour may influence the risk of workplace violence. This knowledge can be harnessed to develop training programs for ambulance personnel.} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_druggedaniel_2025_1, title = {Would a Universal Basic Income Advance Republican Liberty? Understanding the Impact and Implications of a UBI on the Exit Costs Associated with Unemployment}, author = {Drugge, Daniel}, year = {2025}, journal = {Basic Income Studies}, doi = {10.1515/bis-2023-0017}, url = {1991648}, language = {eng}, publisher = {Walter de Gruyter}, keywords = {non-domination; ubi; exit; republican liberty; basic income; unemployment}, abstract = {Would a UBI advance republican liberty? The potential threat to non-domination posed by administrative bureaucracies has led some republican theorists to argue in favour of a UBI. While the strength of the republican case for UBI has been the subject of a robust debate in the literature, insufficient attention has been paid to how the exit costs associated with unemployment are affected by how people perceive and evaluate risk. This paper shows that once we properly account for the fact that people are loss averse and assess exit costs in a context of uncertainty and limited information, we get a better grasp of the non-domination related trade-offs at stake in a decision between an income-maintenance model of welfare provision and a baseline provision model built around a UBI. It identifies and outlines three of these trade-offs and sketches an approach for how to think about these from a non-domination perspective.}, issn = {2194-6094} } @phdthesis{ca0f099bbf2a435cee8f97bef5e8cbaa_unossonhanna_2025, title = {Wound healing complications at the saphenous vein harvest site after coronary artery bypass surgery}, author = {Unosson, Hanna}, year = {2025}, url = {1946172}, language = {eng}, publisher = {Örebro University}, keywords = {coronary artery bypass surgery; harvesting site; leg wound infection; patient safety; surgical site infection; wound healing complications}, abstract = {Coronary artery bypass grafting surgery is the most common cardiothoracic procedure worldwide, and postoperative wound healing complications in the leg harvest site are common. The overall aim of this thesis was to explore varied perspectives of leg wound infection with a focus on routines and methods, the patients’ experiences, and risk factors.In Study I, operating theatre nurses (n=62) and cardiac surgeons (n=56) from Swedish cardiothoracic centres (n=8) responded to a questionnaire regarding hygiene routines and surgical methods. The results indicate both similarities and differences between the centres. There is a lack of evidence regarding common routines and methods, and local routines might be one common factor. In Study II, interviews with patients (n=16) were performed to explore experiences of a serious wound healing complication. Pain, anxiety, and limitations in daily life affected the patients to varying degrees. Study III used local data from the Carath registry (n=2188) to explore risk factors for wound healing complications in the leg wound. Female sex, diabetes mellitus, higher body mass index, peripheral vascular disease, direct oral anticoagulants, and operation time ˃5 hours were detected as risk factors. In Study IV, follow-up data from patients (n=856) were investigated to identify risk factors for leg wound infection and other wound healing complications following coronary artery bypass surgery. Risk factors identified were female sex, vein harvesting technique, impaired left ventricle function, and the specific participating centres. In conclusion, female sex and the vein harvest technique may influence the risk of leg wound infection. Improved patient safety requires evidence-based routines, methods, and guidelines for healthcare professionals, as well as increased person-centred care.}, file = {https://oru.diva-portal.org/smash/get/diva2:1946172/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_thuressonhanna_2025, title = {Yngre förskolebarns litteratursamtal}, author = {Thuresson, Hanna}, year = {2025}, journal = {Nordisk Barnehageforskning}, volume = {22}, number = {1}, pages = {127--144}, doi = {10.23865/nbf.v22.578}, url = {1936094}, language = {swe}, publisher = {Cappelen Damm Akademisk}, keywords = {early childhood education and care; literary conversations; multimodality; play; litteratursamtal; multimodalitet; lek; yngre förskolebarn}, abstract = {Tidiga erfarenheter av litteratur sätter spår i den fortsatta litterata och språkliga utvecklingen, inte minst genom socialisering in i en skriftspråklig kultur. I förskolans kontext pågår litteraturaktiviteter där barn interagerar med andra barn i möten över böcker, digitala skärmar och material för berättande. I dessa möten skaffar sig barnen erfarenheter av andra barns sätt att förstå berättelsers struktur, litteraturens innehåll och hur innehållet kan delas. Artikeln vill bidra med kunskap om hur 1–2-åriga barn interagerar i möten med litteratur och varandra när pedagoger inte är involverade. Tidigare forskning visar att högläsning och litteratursamtal är väsentliga inslag i språkutvecklande undervisning, men det finns utmaningar för förskolans personal att möta barnens läsglädje på ett givande sätt. Med hjälp av en bred definition av litteratursamtal som betonar multimodal kommunikation analyseras observationer av barn som interagerar med varandra runt litteratur och material för berättande. Studien identifierar tre former av litteratursamtal: litteratursamtal med fokus på innehåll och identitet som läsare, litteratursamtal med fokus på handhavande av verktyg och litteratursamtal med fokus på bearbetning i lek. De tre identifierade formerna belyses med praktiknära exempel. Artikeln visar att litteratursamtalen inte är fixerade vid en verbal bearbetning av innehållet utan synliggör olika uttryckssätt för barn att visa sina perspektiv och kunskaper. Slutligen poängteras att barns multimodala litteratursamtal inte bara främjar olika strategier för läsning och berättelser utan även skapar förståelse för olika medier. ;Early experiences with literature leave a lasting impact on continued literacy development, particularly through socialization into a literate culture. In the context of early childhood education, literary activities take place where children interact with other children through books, digital screens, and storytelling materials. In these interactions, children gain insights into other children’s ways of understanding narrative structure, the content of literature, and how this content can be shared. This article aims to contribute knowledge about how children aged 1–2 years interact in literary encounters when educators are not involved. Previous research indicates that reading aloud and literary discussions are essential components of language-developing education, but there are challenges for early childhood educators in engaging with children’s joy of reading in a meaningful way. By using a broad definition of literary discussions that emphasizes multimodal communication, observations of children interacting with each other around literature and storytelling materials are analyzed. The study identifies three types of literary conversations: Literature conversations focusing on content and reader identity, Literature conversations focusing on handling, and Literature conversations focusing on processing through play. The tree identified forms are illustrated with empirical examples. The article indicates that literature conversations are not fixed on verbal processing of the content but highlight different ways for children to express their perspectives and knowledge. Finally, it emphasizes that children’s multimodal literary discussions not only foster different strategies for reading and storytelling but also create an understanding of various media. } } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_hellfeldtkarin_2025, title = {Young adults’ explanations of childhood neglect and their associations with health problems in young adulthood}, author = {Hellfeldt, Karin and Thunberg, Sara and Åsa, Källström}, year = {2025}, journal = {Children and youth services review}, volume = {180}, doi = {10.1016/j.childyouth.2025.108664}, url = {2013840}, language = {eng}, publisher = {Elsevier}, keywords = {neglect; explanations; attribution; self-blame; health outcome; s childhood}, abstract = {Background: Childhood neglect has been associated with various negative short- and long-term consequences. To make sense of difficult experiences, individuals often seek internal and/or external explanations. Children’s explanations for why they experience neglect have been identified as a potentially important factor in relation to different adjustment outcomes.Objective: This study examines how young adults explain the childhood neglect they experienced and how these explanations are connected to health problems in adulthood.Methods: The study utilizes retrospective data from a representative Swedish sample of 2,500 young adults, of which 7.5 % reported having been neglected as a child.Results: Our findings revealed that emotional neglect was the most common form of neglect, while physical neglect was the least common. Most participants attributed the neglect to their parents or family circumstances. However, self-blame during childhood significantly increased the risk of self-harm and PTSD symptoms. Blaming either oneself or one’s parents was associated with a higher likelihood of self-harm and PTSD, while blaming parents for the neglect was linked to more suicide attempts. Those who attributed neglect to family circumstances showed higher levels of alcohol use as adults.Conclusions: It́ s important for professionals to recognize that, in addition to neglect itself, children’s tendency to assign blame—especially self-blame—can have lasting impacts on their mental health and behavior.}, issn = {0190-7409}, file = {https://oru.diva-portal.org/smash/get/diva2:2013840/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_arnelllinda_2025_3, title = {Young Children’s Lives at Domestic Violence Shelters : Mothers’ Perspectives on Their Children’s Experiences}, author = {Arnell, Linda and Thunberg, Sara}, year = {2025}, journal = {Child and Adolescent Social Work Journal}, volume = {42}, number = {1}, pages = {123--134}, doi = {10.1007/s10560-023-00948-7}, url = {1799615}, language = {eng}, publisher = {Springer}, keywords = {children; domestic violence; intimate partner violence; living environment}, abstract = {Purpose: The aim of this study is to analyze mothers’ narratives about their children’s life situation while living at domestic violence shelters in Sweden. More precisely, the analysis focuses on determining what aspects are highlighted as being most important for the children’s living situation during their stay.Method: This study is based on interviews with mothers who have experience of living at a domestic violence shelter together with their young child/ren. Thematic analysis was used to analyze the narratives.Results: The analysis resulted in seven themes important for the children’s lives during their shelter stay. These are: safety, isolation, a child-friendly environment, shared living space, social relations at the shelter, children’s health during their stay, and support at the shelter.Conclusion: In the narratives, safety was highlighted as the most important issue, and as something that also affects other aspects of the children’s lives during their time at the shelter. A child-friendly environment, access to activities and support, and positive social relations at the shelter are also important. In addition, positive experiences regarding these aspects can be understood to counteract the feeling of isolation and improve children’s ability to process their experiences.}, issn = {0738-0151}, file = {https://oru.diva-portal.org/smash/get/diva2:1799615/FULLTEXT01.pdf} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_sjdahlanna_2025, title = {Young students’ enactment patterns in visual programming – 'plan-driven' or 'in-the-moment'}, author = {Sjödahl, Anna and Eckert, Andreas}, year = {2025}, journal = {International Journal of Child-Computer Interaction}, volume = {46}, doi = {10.1016/j.ijcci.2025.100789}, url = {2028196}, language = {eng}, publisher = {Elsevier}, abstract = {Visual programming has become a popular way to provide young students with the opportunity to engage in complex problem-solving, often referred to as computational thinking. Most frameworks for computational thinking are comprehensive yet lack a fine-grained perspective on young students' engagement in programming. Therefore, this paper aims to unpack young students’ enacted problem-solving as they engage in open-ended programming in a visual programming environment (VPE). Through the lens of abstracting and decomposing, we contribute with a close-up understanding of how young students tackle complex problems in a VPE. Data generated in a Swedish first-grade classroom consisted of screen recordings and plans from 13 student pairs, working during four lessons to produce animated stories in ScratchJr. Through the analysis, six enactment patterns were constructed, showing that students as young as seven to eight years old can solve problems involving multiple components, arranging them into cohesive solutions. There were major differences in the problem-solving process involving whether or not the students followed their plans, captured in plan-driven and in-the-moment enactment patterns. Plan-driven enactment patterns elicited shifts within abstracting and decomposing practices, which we consider essential for programming since such enactment patterns more often elicit complex problem-solving. The results suggest that young students should be encouraged to use plans extensively when working in a VPE.}, issn = {2212-8689} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_grenmagnus_2025_1, title = {Yrast states of quantum droplets confined in a ring potential}, author = {Ögren, Magnus and Kavoulakis, G. M.}, year = {2025}, journal = {Physical Review A: covering atomic, molecular, and optical physics and quantum information}, volume = {111}, number = {1}, doi = {10.1103/PhysRevA.111.013305}, url = {1924482}, language = {eng}, publisher = {American Physical Society}, keywords = {quantum droplets; vortices; yrast states}, abstract = {We consider a quantum droplet which is confined in a ring potential. We investigate the so-called yrast state,i.e., the lowest-energy state of the droplet assuming that it has some fixed expectation value of the angularmomentum. Two of the most interesting aspects of this problem are the nonlinear term—which is partly attractive and partly repulsive—and the periodic boundary conditions. For some range of the parameters, the attractive or the repulsive part of the nonlinear term dominates and one gets the expected behavior. In some intermediate regime, the two nonlinear terms are of comparable size. In this case, both the solution and the corresponding dispersion relation show an interesting behavior. Finally, we make contact with the problem of solitary-wave excitation since the derived solutions are traveling-wave, i.e., solitary-wave, solutions.}, issn = {2469-9926} } @article{ca0f099bbf2a435cee8f97bef5e8cbaa_kumargulshan_2025_1, title = {ZAKON : A decentralized framework for digital forensic admissibility and justification}, author = {Kumar, Gulshan and Saha, Rahul and Conti, Mauro and Kim, Tai Hoon}, year = {2025}, journal = {Information Processing & Management}, volume = {62}, number = {6}, doi = {10.1016/j.ipm.2025.104226}, url = {1985475}, language = {eng}, publisher = {Elsevier}, keywords = {digital; forensic; blockchain; provenance; legal; decentralized}, abstract = {Digital forensics has become important in legal cases. It demands accuracy for fair outcomes. Despite advances in evidence handling and analysis, challenges persist in maintaining legal integrity, authenticity, and courtroom admissibility. Existing decentralized frameworks fail to ensure prosecutable evidence in the courtroom. In this paper, we introduce a general decentralized digital evidence framework to address the courtroom admissibility problem mentioned above. Our proposed decentraliZed frAmeworK for fOrensic justificatioN (ZAKON) ensures the ethical, legal, and privacy-based obligations through smart contracts and includes privacy-ensured query resolution. The main contribution of our ZAKON is to use a multidimensional checking for the admissibility of the evidence transactions. Another contribution of our ZAKON is the post-trial query resolution, which is important in crime investigation or making a referential understanding of the investigation processes in multi-case environments. We deploy our ZAKON framework on Hyperledger Fabric and measure the performance based on the Caliper benchmark metrics. ZAKON achieves notable performance improvements. It delivers an average throughput of 8320 TPS, about 70% higher than existing systems, and reduces average latency to 1.85 s, a 29.28% improvement. It maintains a 100% transaction success rate. Resource utilization remains moderate, with peak CPU usage at 4.5% and memory usage at 32.76 MB. ZAKON also ensures linear computational and communication complexity, enabling scalability for real-time forensic applications.}, issn = {0306-4573} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_lundinlina_2025, title = {Zebrafish as a Model to Investigate Nanoparticles}, author = {Lundin, Lina and Keiter, Steffen}, year = {2025}, pages = {365--400}, doi = {10.1007/978-3-031-93871-9_14}, url = {2011777}, language = {eng}, publisher = {Springer}, keywords = {zebrafish; nanoparticles; exposure; uptake; accumulation; toxicity}, abstract = {The rapid development of nanoparticles (NPs) has raised significant concerns regarding their potential toxic effects on both human health and the environment. Zebrafish (Danio rerio) have emerged as a valuable in vivo model for nanotoxicity studies due to their physiological and genetic similarities to humans, high fecundity, transparent embryos, and rapid development. This chapter provides a comprehensive review of zebrafish as a model organism for investigating NP toxicity. It highlights key advantages, including their suitability for high-throughput screening and real-time visualization of NP biodistribution. The chapter discusses various NP uptake pathways, such as the gills, gastrointestinal tract, and blood-brain barrier, and explores the biological barriers that influence NP accumulation. Furthermore, it summarizes toxicological findings on teratogenic, immunotoxic, neurotoxic, and hepatotoxic effects of NPs across different zebrafish life stages. The use of zebrafish allows for the investigation of both acute and chronic NP exposure, offering insights into developmental and reproductive toxicity, oxidative stress, and genotoxicity. By bridging the gap between simple in vitro tests and more complex mammalian models, zebrafish serve as an essential model for assessing the potential risks of nanomaterials for human and environmental health.} } @inproceedings{ca0f099bbf2a435cee8f97bef5e8cbaa_rickenbachrahel_2025, title = {ZipMPC : Compressed Context-Dependent MPC Cost via Imitation Learning}, author = {Rickenbach, Rahel and Lahoud, Alan and Schaffernicht, Erik and Zeilinger, Melanie and Stork, Johannes Andreas}, year = {2025}, url = {2019664}, language = {eng}, keywords = {imitation learning; model predictive control; context-dependent control}, abstract = {The computational burden of model predictive control (MPC) limits its application on real-time systems, such as robots, and often requires the use of short prediction horizons. This not only affects the control performance, but also increases the difficulty of designing MPC cost functions that reflect the desired long-term objective. This paper proposes ZipMPC, a method that imitates a long-horizon MPC behaviour by learning a compressed and context-dependent cost function for a short-horizon MPC. It improves performance over alternative methods, such as approximate explicit MPC and automatic cost parameter tuning, in particular in terms of i) optimizing the long term objective; ii) maintaining computational costs comparable to a short-horizon MPC; iii) ensuring constraint satisfaction; and iv) generalizing control behaviour to environments not observed during training. For this purpose, ZipMPC leverages the concept of differentiable MPC with neural networks to propagate gradients of the imitation loss through the MPC optimization. We validate our proposed method in simulation and real-world experiments on autonomous racing. ZipMPC consistently completes laps faster than selected baselines, achieving lap times close to the long-horizon MPC baseline. In challenging scenarios where the short-horizon MPC baseline fails to complete a lap, ZipMPC is able to do so. In particular, these performance gains are also observed on tracks unseen during training.}, file = {https://oru.diva-portal.org/smash/get/diva2:2019664/FULLTEXT01.pdf} } @misc{ca0f099bbf2a435cee8f97bef5e8cbaa_wgerjonny_2025_1, title = {Ämnesdidaktik för elever med intellektuell funktionsnedsättning : Hållbart och meningsfullt lärande}, author = {Wåger, Jonny and Östlund, Daniel}, year = {2025}, url = {1965252}, language = {swe}, publisher = {Studentlitteratur AB} } @incollection{ca0f099bbf2a435cee8f97bef5e8cbaa_linnagneta_2025_1, title = {Örebro : Läroplansteori och utbildningshistoria}, author = {Linné, Agneta and Lundahl, Christian and Westberg, Johannes}, year = {2025}, pages = {221--238}, url = {2012466}, language = {swe}, publisher = {Uppsala universitet} } @techreport{ca0f099bbf2a435cee8f97bef5e8cbaa_kristofferssoneleonor_2025_32, title = {Övertagande av godkännanden och medgivanden inom punktskatteområdet vid konkurs – prop. 2024/25:83}, author = {Kristoffersson, Eleonor}, year = {2025}, url = {2031767}, language = {swe}, publisher = {Norstedts Juridik AB}, keywords = {skatterätt}, abstract = {I proposition 2024/25:83 föreslås nya regler om övertagande av godkännanden och medgivanden inom punktskatteområden vid konkurs. Reglerna föreslås träda i kraft den 1 juli 2025. Professor Eleonor Kristoffersson kommenterar lagförslaget.} }